Dr Simon G Danby
BSc (Hon) PhD
Clinical Medicine, School of Medicine and Population Health
Senior Research Fellow
s.danby@sheffield.ac.uk
+44 114 215 9563
+44 114 215 9563
Room K123, The Medical School
Full contact details
Dr Simon G Danby
Clinical Medicine, School of Medicine and Population Health
Room K123
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Clinical Medicine, School of Medicine and Population Health
Room K123
The Medical School
Beech Hill Road
Sheffield
S10 2RX
- Profile
-
For enquiries please contact - ClinMed-Operational@sheffield.ac.uk
Originally trained in biochemistry and molecular biology I joined the University of Sheffield in 2005 as a post-doctoral scientist in the Academic Unit of Biomedical Genetics. In this position I worked exclusively for York Pharma on the early stage development of novel therapeutics and diagnostics for atopic dermatitis, psoriasis and malignant melanoma. In 2009 I joined Sheffield Dermatology Research as a post-doctoral Research Associate. The focus of my research in this role was improving our understanding of the structure and function of the epidermal (skin) barrier and its role in the development of disorders such as atopic dermatitis (AD). At the beginning of 2012 I was awarded a 3-year unencumbered research fellowship from Johnson & Johnson to continue my research on the skin barrier and set up a dedicated research facility for conducting human skin research. Since then I have continued to conduct and lead translational dermatology research as an independent fellow.
- Research interests
-
The skin serves as an important barrier that keeps moisture in the body and prevents the incursion of harmful exogenous agents, such as irritants and allergens, and resists the invasion of pathogens. A growing body of evidence suggests a primary role for the ‘skin barrier’ in the pathogenesis of a broad range of inflammatory skin disorders, including contact dermatitis, ichthyosis, psoriasis, rosacea and atopic dermatitis (AD). Repeated barrier disruption for instance induces epidermal hyperplasia and inflammation. Current medicine is based on the reactive treatment of these downstream consequences of skin barrier dysfunction, and includes the use of both anti-inflammatory and anti-proliferative compounds. My research focuses on increasing our understanding of the skin barrier defect and developing treatments to correct it under the following core themes:
- Gene-environment interactions in the development of atopic dermatitis
- Development of treatments for atopic dermatitis
- The improvement of neonatal skincare
- Interaction of topical pharmaceutical and cosmetic agents with the skin barrier
A greater understanding of the underlying skin barrier defect promises to firstly identify susceptible individuals early on, and secondly to deliver novel therapeutic options for targeted skin barrier repair with the potential to prevent the development of clinical disease.
Current Projects:
- Characterisation of the skin barrier defect in atopic dermatitis using ATR-FTIR spectroscopy
- Improving neonatal skincare: the Skin Testing for Atopic eczema Risk (STAR) study
- Characterizing the microcirculation of atopic dermatitis using angiographic optical coherence tomography
- Evaluation of topical emollients and bath/wash emollients
- Effect of topical anti-inflammatory treatments on the structure and function of the skin barrier
- Hygiene and emollient interventions for maintaining skin integrity in older people in hospital and residential care settings
- A Comparison between Optical Coherence Tomography (OCT) determined basal cell carcinoma (BCC) margins against surgeon excision margins and histology – an observational pilot study
- Publications
-
Show: Featured publications All publications
Featured publications
Journal articles
- Association between skin barrier development and early-onset atopic dermatitis: a longitudinal birth cohort study. Journal of Allergy and Clinical Immunology. View this article in WRRO
- Morphological parametric mapping of 21 skin sites throughout the body using optical coherence tomography. Journal of the Mechanical Behavior of Biomedical Materials. View this article in WRRO
- The Effect of Water Hardness on Surfactant Deposition after Washing and Subsequent Skin Irritation in Atopic Dermatitis Patients and Healthy Control Subjects. Journal of Investigative Dermatology, 138(1), 68-77. View this article in WRRO
- Vitamin D and antimicrobial peptide levels in patients with atopic dermatitis and atopic dermatitis complicated by eczema herpeticum: A pilot study. Journal of Allergy and Clinical Immunology, 138(5), 1715-1719.e4. View this article in WRRO
- A functional mechanistic study of the effect of emollients on the structure and function of the skin barrier. British Journal of Dermatology, 175(5), 1011-1019. View this article in WRRO
- Development of stratum corneum chymotrypsin-like protease activity and natural moisturizing factors from birth to 4 weeks of age compared with adults. British Journal of Dermatology, 175(4), 713-720. View this article in WRRO
- The Effect of an Emollient Containing Urea, Ceramide NP, and Lactate on Skin Barrier Structure and Function in Older People with Dry Skin. Skin Pharmacology and Physiology, 29(3), 135-147. View this article in WRRO
- Biological Variation in Skin Barrier Function: From A (Atopic Dermatitis) to X (Xerosis). Current Problems in Dermatology (Switzerland), 49, 47-60.
- Olive Oil, Sunflower Oil or no Oil for Baby Dry Skin or Massage: A Pilot, Assessor-blinded, Randomized Controlled Trial (the Oil in Baby SkincaRE [OBSeRvE] Study). Acta Dermato Venereologica, 96(3), 323-330.
- Comparing the Effect of a Twice-weekly Tacrolimus and Betamethasone Valerate Dose on the Subclinical Epidermal Barrier Defect in Atopic Dermatitis. Acta Dermato Venereologica, 95(6), 653-658.
- Hygiene and emollient interventions for maintaining skin integrity in older people in hospital and residential care settings. Cochrane Database of Systematic Reviews, 2014(12), 1-16.
- The effect of tacrolimus compared with betamethasone valerate on the skin barrier in volunteers with quiescent atopic dermatitis.. Br J Dermatol, 170(4), 914-921.
- The effect of aqueous cream BP on the skin barrier in volunteers with a previous history of atopic dermatitis.. Br J Dermatol, 165(2), 329-334.
- A New Understanding Of Atopic Dermatitis: The Role Of Epidermal Barrier Dysfunction And Subclinical Inflammation. Journal of Clinical Dermatology, 1, 33-46.
- Epidermal barrier dysfunction in atopic dermatitis.. J Invest Dermatol, 129(8), 1892-1908.
Chapters
- Neonatal Skin Care and Toxicology In Eichenfield LF, Frieden IJ, Zaenglein A & Mathes E (Ed.), Neonatal and Infant Dermatology (pp. 46-56). Saunders
- Current and Future Trends: Skin Diseases and Treatment In Benson HAE & Watkinson AC (Ed.), Topical and Transdermal Drug Delivery Wiley
- The Skin Barrier in Atopic Dermatitis. In Irvine A, Hoeger P & Yan A (Ed.), Textbook of Pediatric Dermatology, UK: Blackwell Publishing Ltd..
- Epidermal Barrier Dysfunction in Atopic Dermatitis In Rawlings L (Ed.), Skin Moisturization USA: Informa Healthcare USA Inc..
Reports
- A systematic review of skin irritation and tap water
All publications
Journal articles
- Les enfants atteints de dermatite atopique répondent plus rapidement au traitement par dupilumab que les adolescents et les adultes. Annales de Dermatologie et de Vénéréologie - FMC, 4(8), A205-A206.
- 53081 Dupilumab Treatment Provides Sustained Improvement in Skin Barrier Function, Clinical Outcomes, and Patient-Reported Outcomes in Patients Aged 6 to 11 Years With Moderate-to-Severe Atopic Dermatitis. Journal of the American Academy of Dermatology, 91(3), AB34-AB34.
- 52273 Dupilumab Provides Sustained Normalization of Skin Barrier Function in Children With Moderate-to-Severe Atopic Dermatitis. Journal of the American Academy of Dermatology, 91(3), AB34-AB34.
- 52909 MOISTURIZER WITH SKIN IDENTICAL LIPIDS RESTORES BARRIER FUNCTION IN ECZMEA-PRONE SKIN AND REDUCES SKIN SUSCEPTIBILITY TO IRRITANTS. Journal of the American Academy of Dermatology, 91(3), AB259-AB259.
- Effects of a pH-regulating emollient cream in mild atopic dermatitis patients with moderate localized lesions. Skin Pharmacology and Physiology, 37, 49-58. View this article in WRRO
- 280 Children with atopic dermatitis respond more rapidly to dupilumab treatment in comparison to adolescents and adults. Journal of Investigative Dermatology, 144(8), S48-S48.
- P036 Dupilumab treatment normalizes skin barrier function in children aged 6–11 years with moderate-to-severe atopic dermatitis. British Journal of Dermatology, 191(Supplement_1), i30-i30.
- Dupilumab treatment in pediatric patients aged 6–11 years with severe atopic dermatitis whose disease Is not adequately controlled: a review. Drug Design, Development and Therapy, 18, 277-289. View this article in WRRO
- Dupilumab Improves Skin Lipid Barrier in Pediatric Patients With Moderate-to-Severe Atopic Dermatitis. Journal of Allergy and Clinical Immunology, 153(2), AB5-AB5.
- Association between skin barrier development and early-onset atopic dermatitis: a longitudinal birth cohort study. Journal of Allergy and Clinical Immunology. View this article in WRRO
- P26 Characterization of skin barrier defects in atopic dermatitis patients using attenuated total reflection Fourier transform infrared spectroscopy. British Journal of Dermatology, 189(1), e24-e24.
- Are mild cleansers appropriate for hand hygiene in the COVID era? An in vitro investigation of the antiviral efficacy of different hand hygiene products. Frontiers in Virology, 3.
- Targeting skin barrier function in atopic dermatitis. The Journal of Allergy and Clinical Immunology: In Practice.
- c‐Src activation as a potential marker of chemical‐induced skin irritation using tissue‐engineered skin equivalents. Experimental Dermatology. View this article in WRRO
- REAL-TIME INFRARED Spectroscopic measurement of Natural Moisturising Factor. Journal of Investigative Dermatology.
- Effect of seasonal change on the biomechanical and physical properties of the human skin. Journal of the Mechanical Behavior of Biomedical Materials, 127. View this article in WRRO
- Moisturizer therapy in prevention of atopic dermatitis and food allergy: to use or disuse?. Annals of Allergy, Asthma & Immunology.
- Different types of emollient cream exhibit diverse physiological effects on the skin barrier in adults with atopic dermatitis. Clinical and Experimental Dermatology.
- Enhancement of stratum corneum lipid structure improves skin barrier function and protects against irritation in adults with dry, eczema‐prone, skin. British Journal of Dermatology.
- Determination of chemical irritation potential using a defined gene signature set on tissue-engineered human skin equivalents. JID Innovations, 100011-100011. View this article in WRRO
- Imaging striae distensae: a comparisonbetween PS-OCT and digital dermoscopy. Biomedical Optics Express.
- 16818 An investigation of the skin barrier restoring effects of a cream containing ceramides in a multivesicular emulsion in people with dry, eczema-prone, skin: The RESTORE study phase 2. Journal of the American Academy of Dermatology, 83(6), AB71-AB71.
- Vehicles for atopic dermatitis therapies: more than just a placebo. Journal of Dermatological Treatment. View this article in WRRO
- An investigation of the skin barrier restoring effects of a cream and lotion containing ceramides in a multi-vesicular emulsion in people with dry, eczema-prone, skin: The RESTORE study phase 1. Dermatology and Therapy. View this article in WRRO
- Morphological parametric mapping of 21 skin sites throughout the body using optical coherence tomography. Journal of the Mechanical Behavior of Biomedical Materials. View this article in WRRO
- Protocol for an outcome assessor-blinded pilot randomised controlled trial of an ion-exchange water softener for the prevention of atopic eczema in neonates, with an embedded mechanistic study : the softened water for eczema prevention (SOFTER) trial. BMJ Open, 9(8). View this article in WRRO
- Research Techniques Made Simple: Transepidermal Water Loss Measurement as a Research Tool. Journal of Investigative Dermatology, 138(11), 2295-2300.e1.
- Towards a better understanding of outcome measurement instruments for atopic eczema.. Br J Dermatol, 179(2), 246-247.
- Infant Skin Barrier, Structure, and Enzymatic Activity Differ from Those of Adult in an East Asian Cohort. BioMed Research International, 2018. View this article in WRRO
- Sub-clinical assessment of atopic dermatitis severity using angiographic optical coherence tomography. Biomedical Optics Express, 9(4), 2001-2001. View this article in WRRO
- The Effect of Water Hardness on Surfactant Deposition after Washing and Subsequent Skin Irritation in Atopic Dermatitis Patients and Healthy Control Subjects. Journal of Investigative Dermatology, 138(1), 68-77. View this article in WRRO
- Staphylococcus aureus in atopic dermatitis: a diverse problem?. British Journal of Dermatology, 177(5), 1164-1164.
- The British Skin Foundation: 20 years of supporting dermatology research. British Journal of Dermatology, 177(3), 608-609.
- Computational design of treatment strategies for proactive therapy on atopic dermatitis using optimal control theory. Royal Society of London. Philosophical Transactions A. Mathematical, Physical and Engineering Sciences, 375(2096). View this article in WRRO
- Biologic Treatments for Atopic Eczema: Anti IL-4 and IL-13 biologics. Exchange: National Eczema Society Members' Magazine(163), 11-18. View this article in WRRO
- Vitamin D and antimicrobial peptide levels in patients with atopic dermatitis and atopic dermatitis complicated by eczema herpeticum: A pilot study. Journal of Allergy and Clinical Immunology, 138(5), 1715-1719.e4. View this article in WRRO
- A functional mechanistic study of the effect of emollients on the structure and function of the skin barrier. British Journal of Dermatology, 175(5), 1011-1019. View this article in WRRO
- Development of stratum corneum chymotrypsin-like protease activity and natural moisturizing factors from birth to 4 weeks of age compared with adults. British Journal of Dermatology, 175(4), 713-720. View this article in WRRO
- The Effect of an Emollient Containing Urea, Ceramide NP, and Lactate on Skin Barrier Structure and Function in Older People with Dry Skin. Skin Pharmacology and Physiology, 29(3), 135-147. View this article in WRRO
- Biological Variation in Skin Barrier Function: From A (Atopic Dermatitis) to X (Xerosis). Current Problems in Dermatology (Switzerland), 49, 47-60.
- Olive Oil, Sunflower Oil or no Oil for Baby Dry Skin or Massage: A Pilot, Assessor-blinded, Randomized Controlled Trial (the Oil in Baby SkincaRE [OBSeRvE] Study). Acta Dermato Venereologica, 96(3), 323-330.
- Comparing the Effect of a Twice-weekly Tacrolimus and Betamethasone Valerate Dose on the Subclinical Epidermal Barrier Defect in Atopic Dermatitis. Acta Dermato Venereologica, 95(6), 653-658.
- Hygiene and emollient interventions for maintaining skin integrity in older people in hospital and residential care settings. Cochrane Database of Systematic Reviews, 2014(12), 1-16.
- A new perspective on histamine in atopic dermatitis. British Journal of Dermatology, 171(4), 688-688.
- The effect of tacrolimus compared with betamethasone valerate on the skin barrier in volunteers with quiescent atopic dermatitis.. Br J Dermatol, 170(4), 914-921.
- The effects of pimecrolimus on the innate immune response in atopic dermatitis.. Br J Dermatol, 168(2), 235-236.
- Optical coherence tomography demonstrates differential epidermal thinning of human forearm volar skin after 2 weeks application of a topical corticosteroid vs a non-steroidal anti-inflammatory alternative. Photonic Therapeutics and Diagnostics IX.
- Effect of olive and sunflower seed oil on the adult skin barrier: implications for neonatal skin care.. Pediatr Dermatol, 30(1), 42-50.
- Aqueous cream damages the skin barrier. British Journal of Dermatology, 164(6), 1179-1180.
- The effect of aqueous cream BP on the skin barrier in volunteers with a previous history of atopic dermatitis.. Br J Dermatol, 165(2), 329-334.
- Use of oil for baby skincare: A survey of UK maternity and neonatal units. British Journal of Midwifery, 19(6), 354-362.
- Use of oil for baby skincare: A survey of UK maternity and neonatal units. British Journal of Midwifery, 19(6), 354-362.
- A New Understanding Of Atopic Dermatitis: The Role Of Epidermal Barrier Dysfunction And Subclinical Inflammation. Journal of Clinical Dermatology, 1, 33-46.
- Expression of the multi-drug efflux genes acrAB of 'Escherichia coli'..
- Epidermal barrier dysfunction in atopic dermatitis.. J Invest Dermatol, 129(8), 1892-1908.
- Skin barrier breakdown: a renaissance in emollient therapy. British Journal of Nursing, 18(14), 872-877.
- Gene-environment interactions in atopic dermatitis. Drug Discovery Today: Disease Mechanisms, 5, e11-e31.
- Gene–environment interactions in atopic dermatitis. Drug Discovery Today: Disease Mechanisms, 5(1), e11-e31.
- Increased expression of the multidrug efflux genes acrAB occurs during slow growth of Escherichia coli.. FEMS Microbiol Lett, 207(1), 91-95.
- Increased expression of the multidrug efflux genesacrABoccurs during slow growth ofEscherichia coli. FEMS Microbiology Letters, 207(1), 91-95.
- Real-Time In Vivo Human Skin Testing Using a Handheld Fourier Transform Infrared Spectrometer with a Three-Bounce Two-Pass Attenuated Total Reflection Interface. Applied Spectroscopy.
- A Practical Guide to Using Oral JAK Inhibitors for Atopic Dermatitis from the International Eczema Council. British Journal of Dermatology.
- Novel biophysical skin biomarkers discriminate topical anti‐inflammatory treatments based on their potential for local adverse effects. JEADV Clinical Practice.
- Debunking the myth that all emollients are equal opens the door for future AD prevention studies. British Journal of Dermatology.
- Maintenance of an Acidic Skin Surface with a Novel Zinc Lactobionate Emollient Preparation Improves Skin Barrier Function in Patients with Atopic Dermatitis. Dermatology and Therapy.
- Characterisation of skin barrier defects in atopic dermatitis patients using Infrared Spectroscopy. Clinical and Experimental Dermatology.
- The potential application of PS-OCT in the safety assessment of non-steroidal topical creams for Atopic Dermatitis treatment. Biomedical Optics Express.
- Randomized controlled pilot trial with ion‐exchange water softeners to prevent eczema (SOFTER trial). Clinical & Experimental Allergy.
- The effect of water hardness on atopic eczema and skin barrier function: A systematic review and meta‐analysis. Clinical & Experimental Allergy.
- Hygiene and emollient interventions for maintaining skin integrity in older people in hospital and residential care settings. Cochrane Database of Systematic Reviews.
- Topical corticosteroid vehicle composition and implications for clinical practice. Clinical and Experimental Dermatology.
- Atopic dermatitis epidemiology and unmet need in the United Kingdom. Journal of Dermatological Treatment. View this article in WRRO
- Response to: Letter to the Editor Regarding “An Investigation of the Skin Barrier Restoring Effects of a Cream and Lotion Containing Ceramides in a Multi-Vesicular Emulsion in People with Dry, Eczema-Prone, Skin: The RESTORE Study Phase 1”. Dermatology and Therapy.
Chapters
- pH in Atopic Dermatitis, pH of the Skin: Issues and Challenges (pp. 95-107). S. Karger AG
- Neonatal Skin Care and Toxicology In Eichenfield LF, Frieden IJ, Zaenglein A & Mathes E (Ed.), Neonatal and Infant Dermatology (pp. 46-56). Saunders
- Current and Future Trends: Skin Diseases and Treatment In Benson HAE & Watkinson AC (Ed.), Topical and Transdermal Drug Delivery Wiley
- The Skin Barrier in Atopic Dermatitis. In Irvine A, Hoeger P & Yan A (Ed.), Textbook of Pediatric Dermatology, UK: Blackwell Publishing Ltd..
- Skin Barrier Dysfunction in Atopic Dermatitis, Basic and Clinical Dermatology (pp. 211-240). Informa Healthcare
- Epidermal Barrier Dysfunction in Atopic Dermatitis In Rawlings L (Ed.), Skin Moisturization USA: Informa Healthcare USA Inc..
Conference proceedings papers
- 55 Dupilumab treatment normalizes skin barrier function and improves patient-reported outcomes in patients aged 6 to 11 years with moderate-to-severe atopic dermatitis. Journal of Investigative Dermatology, Vol. 143(11) (pp S342-S342)
- Dupilumab treatment normalizes skin barrier function and improves patient-reported outcomes in patients aged 6 to 11 years with moderate-to-severe atopic dermatitis. JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol. 143(11) (pp S342-S342)
- AN IN VITRO IMMUNOCOMPETENT HUMAN TISSUE-ENGINEERED MODEL OF ATOPIC DERMATITIS FOR DRUG TESTING. TISSUE ENGINEERING PART A, Vol. 29(11-12) (pp 492-492)
- P39: Development of an in vitro immunocompetent human skin-equivalent model. British Journal of Dermatology, Vol. 187(1) (pp E29-E29). Virtual, 29 March 2021 - 29 March 2021. View this article in WRRO
- P42: Development and validation of tissue-engineered human skin equivalents to detect stinging potential. British Journal of Dermatology, Vol. 187(1) (pp E31-E31). Virtual, 29 March 2021 - 29 March 2021. View this article in WRRO
- EFFECTS OF EMOLLIENT CREAMS ON THE SKIN BARRIER OF PATIENTS WITH ATOPIC DERMATITIS. ACTA DERMATO-VENEREOLOGICA, Vol. 102 (pp 35-36)
- SKIN TESTING TO DETERMINE ATOPIC DERMATITIS RISK: AN OBSERVATIONAL BIRTH COHORT STUDY. ACTA DERMATO-VENEREOLOGICA, Vol. 102 (pp 15-15)
- A RANDOMIZED CONTROLLED PHASE 2 TRIAL COMPARING THE EFFECTS OF CRISABOROLE 2% OINTMENT TO BETAMETHASONE VALERATE 0.1% CREAM ON SKIN STRUCTURE IN PARTICIPANTS WITH ATOPIC DERMATITIS. ACTA DERMATO-VENEREOLOGICA, Vol. 102 (pp 56-57)
- Assessing the severity of striae distensae using polarization-sensitive optical coherence tomography. BRITISH JOURNAL OF DERMATOLOGY, Vol. 187(1) (pp E22-E23)
- LOWERING SKIN SURFACE PH WITH A TOPICAL ZINC LACTOBIONATE PREPARATION CONTAINING PHYSIOLOGIC LIPIDS IMPROVES SKIN BARRIER STRUCTURE AND FUNCTION IN ADULTS WITH ATOPIC DERMATITIS. ACTA DERMATO-VENEREOLOGICA, Vol. 101 (pp 51-51)
- An investigation of the skin barrier restoring effects of a cream containing ceramides in a multivesicular emulsion in people with dry, eczema-prone, skin: The RESTORE study phase 2. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, Vol. 83(6) (pp AB71-AB71)
- Quantification of natural moisturizing factors at the skin surface using a portable infrared spectrometer device: a pilot, calibration model. BRITISH JOURNAL OF DERMATOLOGY, Vol. 179(1) (pp E35-E36) View this article in WRRO
- Characterizing the microcirculation of atopic dermatitis using angiographic optical coherence tomography. Proceedings of SPIE, Vol. 10037 View this article in WRRO
- The role of domestic water hardness in the development of skin barrier dysfunction and atopic eczema: a systematic review of the literature. BRITISH JOURNAL OF DERMATOLOGY, Vol. 177 (pp 159-159)
- 129 Characterisation of the skin barrier defect in atopic dermatitis using in vivo ATR-FTIR spectroscopy. Journal of Investigative Dermatology, Vol. 136(9) (pp S182-S182)
- A pilot, assessor-blinded, randomized controlled trial of topical oils for neonatal skin. BRITISH JOURNAL OF DERMATOLOGY, Vol. 173 (pp 153-153)
- Noninvasive assessment of the lipid structure and water holding properties of the stratum corneum in vivo by ATR-FTIR using a fibre optic probe in patients with atopic dermatitis and healthy controls. BRITISH JOURNAL OF DERMATOLOGY, Vol. 170(6) (pp E29-E29)
- The effect of a complex emollient cream containing 5% urea, ceramide 3 and lactic acid, compared with a simple emollient, on the skin barrier in older people with dry skin. BRITISH JOURNAL OF DERMATOLOGY, Vol. 171 (pp 57-58)
- Chymotrypsin-like protease activity in the stratum corneum is increased in atopic dermatitis and upon washing with soap. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, Vol. 68(4) (pp AB172-AB172)
- Vitamin D supplementation improves atopic dermatitis and atopic dermatitis complicated by eczema herpeticum. BRITISH JOURNAL OF DERMATOLOGY, Vol. 167 (pp 127-127)
- A randomized comparison of aqueous cream and Oilatum® Junior bath additive on skin barrier function in atopic dermatitis. BRITISH JOURNAL OF DERMATOLOGY, Vol. 165 (pp 44-45)
- A randomized comparison of aqueous cream and Oilatum® Junior bath additive on skin barrier function in atopic dermatitis. BRITISH JOURNAL OF DERMATOLOGY, Vol. 165 (pp 115-115)
- Skin protease inhibitors: a new treatment for atopic dermatitis. BRITISH JOURNAL OF DERMATOLOGY, Vol. 161 (pp 30-31)
- British Society for Paediatric Dermatology. British Journal of Dermatology, Vol. 161 (pp 115-127)
- Skin protease inhibitors: A new treatment for atopic dermatitis. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, Vol. 60(3) (pp AB67-AB67)
Reports
- A systematic review of skin irritation and tap water
Posters
- P24 Emollient use and effects on cutaneous allergen reactions: a preliminary study.
- Association between skin barrier development and early-onset atopic dermatitis: a longitudinal birth cohort study. Journal of Allergy and Clinical Immunology. View this article in WRRO
- Teaching interests
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- I teach on the undergraduate medical degree course (Common skin conditions and skin pharmacology) and on the Molecular Medicine MSc (Experimental medicine pathway, modules MED6020 & MED6021 Cellular and Molecular Basis of Disease)
- I supervise undergraduate BMedSci and Research Attachment SSC projects conducted within our dedicated skin barrier research suite
- I also deliver external educational presentations to healthcare professionals on topics covering skin physiology, skincare, atopic dermatitis and the mechanisms of topical therapies for atopic dermatitis
- Professional activities and memberships
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- Member of the European Society for Dermatological Research (ESDR)
- Manager of the “Skin Barrier Research Facility” housing a range of bioinstrumentation for the assessment of human skin in vivo non-invasively