Dr Neil Stewart
Clinical Medicine, School of Medicine and Population Health
UKRI Future Leaders Fellow
+44 114 215 9148
Full contact details
Clinical Medicine, School of Medicine and Population Health
Polaris
18 Claremont Crescent
Sheffield
S10 2TA
- Profile
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For enquiries please contact - ClinMed-Operational@sheffield.ac.uk
I obtained a degree in physics from Durham University in 2012, and a PhD in magnetic resonance imaging physics from the University of Sheffield in 2016. In 2017, I moved to Hokkaido University to undertake a post-doctoral research fellowship funded by the Japan Society for the Promotion of Science (JSPS). I am currently undertaking a European Respiratory Society (ERS) Marie Curie post-doctoral research fellowship in the POLARIS group at the University of Sheffield, in collaboration with the Center for Pulmonary Imaging Research (CPIR) at Cincinnati Children’s Hospital.
- Research interests
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My research interests include the development and optimisation of MRI methods for hyperpolarised media and lung imaging.
- Current Projects
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• Feasibility of hyperpolarised 129Xe MRI of the lungs in the infant population
• Pulse sequence development for multi-nuclear (1H and 129Xe) structure-function MRI of the lungs
• Hyperpolarisation technology development for 129Xe gas and 13C compounds by parahydrogen-induced polarisation
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- Lung MRI with hyperpolarised gases : current & future clinical perspectives. The British Journal of Radiology, 94. View this article in WRRO
- Hyperpolarized 13 C Magnetic Resonance Imaging of Fumarate Metabolism by Parahydrogen‐induced Polarization: A Proof‐of‐Concept in vivo Study. ChemPhysChem, 22(10), 905-905.
- Dissolved 129Xe lung MRI with four‐echo 3D radial spectroscopic imaging: quantification of regional gas transfer in idiopathic pulmonary fibrosis. Magnetic Resonance in Medicine. View this article in WRRO
- Biomedical applications of the dynamic nuclear polarization and parahydrogen induced polarization techniques for hyperpolarized 13C MR imaging. Magnetic Resonance in Medical Sciences. View this article in WRRO
- Hyperpolarised xenon magnetic resonance spectroscopy for the longitudinal assessment of changes in gas diffusion in IPF. Thorax, 74(5), 500-502. View this article in WRRO
- Comparison of 3 He and 129 Xe MRI for evaluation of lung microstructure and ventilation at 1.5T. Journal of Magnetic Resonance Imaging, 48(3), 632-642. View this article in WRRO
- Whole lung morphometry with 3D multiple b‐value hyperpolarized gas MRI and compressed sensing. Magnetic Resonance in Medicine, 77(5), 1916-1925. View this article in WRRO
- Hyperpolarized (13) C,(15) N2 -Urea MRI for assessment of the urea gradient in the porcine kidney.. Magnetic Resonance in Medicine, 76(6), 1895-1899. View this article in WRRO
- Reproducibility of quantitative indices of lung function and microstructure from 129Xe chemical shift saturation recovery (CSSR) MR spectroscopy. Magnetic Resonance in Medicine. View this article in WRRO
- High resolution spectroscopy and chemical shift imaging of hyperpolarized 129Xe dissolved in the human brain in vivo at 1.5 tesla. Magnetic Resonance in Medicine, 75(6), 2227-2234. View this article in WRRO
- Feasibility of human lung ventilation imaging using highly polarized naturally abundant xenon and optimized three-dimensional steady-state free precession. Magnetic Resonance in Medicine, 74(2), 346-352. View this article in WRRO
- Experimental validation of the hyperpolarized 129 Xe chemical shift saturation recovery technique in healthy volunteers and subjects with interstitial lung disease. Magnetic Resonance in Medicine, 74(1), 196-207. View this article in WRRO
All publications
Journal articles
- Relationship between Pulmonary Gas Exchange Function and Brain Uptake Dynamics Investigated with Hyperpolarized <sup>129</sup>Xe MR Imaging and Spectroscopy in a Murine Model of Chronic Obstructive Pulmonary Disease. Magnetic Resonance in Medical Sciences.
- Parahydrogen-induced 13C hyperpolarizer using a flow guide for magnetic field cycling to evoke 1H-13C spin order transfer toward metabolic MRI. IEEE Transactions on Biomedical Engineering, 1-8.
- Initial feasibility and challenges of hyperpolarized
129Xe MRI in neonates with bronchopulmonary dysplasia. Magnetic Resonance in Medicine. - Longitudinal lung function assessment of patients hospitalised with COVID-19 using 1H and 129Xe lung MRI. Chest.
- Targeted imaging of lung cancer with hyperpolarized 129Xe MRI using surface-modified iron oxide nanoparticles as molecular contrast agents. Cancers, 14(24).
- Protocols for multi-site trials using hyperpolarized 129Xe MRI for imaging of ventilation, alveolar-airspace size, and gas exchange: A position paper from the 129Xe MRI clinical trials consortium. Magnetic Resonance in Medicine.
- Human upper-airway respiratory airflow: In vivo comparison of computational fluid dynamics simulations and hyperpolarized 129Xe phase contrast MRI velocimetry. PLoS ONE, 16(8).
- Hyperpolarized 13C MRI as a tool for imaging tissue redox state, oxidative stress, inflammation and cellular metabolism. Antioxidants & Redox Signaling.
- Inflammation during lung cancer progression and ethyl pyruvate treatment observed by pulmonary functional hyperpolarized 129Xe MRI in mice. Contrast Media & Molecular Imaging, 2021, 1-10.
- Lung MRI with hyperpolarised gases : current & future clinical perspectives. The British Journal of Radiology, 94. View this article in WRRO
- Front Cover: Hyperpolarized 13C Magnetic Resonance Imaging of Fumarate Metabolism by Parahydrogen‐induced Polarization: A Proof‐of‐Concept in vivo Study (ChemPhysChem 10/2021). ChemPhysChem, 22(10), 904-904.
- Hyperpolarized 13 C Magnetic Resonance Imaging of Fumarate Metabolism by Parahydrogen‐induced Polarization: A Proof‐of‐Concept in vivo Study. ChemPhysChem, 22(10), 905-905.
- In Vivo Methods and Applications of Xenon-129 Magnetic Resonance. Progress in Nuclear Magnetic Resonance Spectroscopy.
- Dissolved 129Xe lung MRI with four‐echo 3D radial spectroscopic imaging: quantification of regional gas transfer in idiopathic pulmonary fibrosis. Magnetic Resonance in Medicine. View this article in WRRO
- Biomedical applications of the dynamic nuclear polarization and parahydrogen induced polarization techniques for hyperpolarized 13C MR imaging. Magnetic Resonance in Medical Sciences. View this article in WRRO
- Simultaneous T2* mapping of 14N- and 15N-labeled dicarboxy-PROXYLs using CW-EPR-based single-point imaging. Journal of Magnetic Resonance, 305, 122-130. View this article in WRRO
- Hyperpolarised xenon magnetic resonance spectroscopy for the longitudinal assessment of changes in gas diffusion in IPF. Thorax, 74(5), 500-502. View this article in WRRO
- Experimental and quantitative imaging techniques in interstitial lung disease. Thorax, 74(6), 611-619. View this article in WRRO
- Single breath-held acquisition of co-registered 3D 129Xe lung ventilation and anatomical proton images of the human lung with compressed sensing. Magnetic Resonance in Medicine. View this article in WRRO
- Airway microstructure in idiopathic pulmonary fibrosis: Assessment at hyperpolarized 3He diffusion-weighted MRI. Radiology, 291(1). View this article in WRRO
- Assessment of brain perfusion using hyperpolarized 129Xe MRI in a subject with established stroke.. Journal of Magnetic Resonance Imaging. View this article in WRRO
- In vivo extracellular pH mapping of tumors using electron paramagnetic resonance. Analytical Chemistry, 90(23), 13938-13945. View this article in WRRO
- Diagnostic and prognostic significance of cardiovascular magnetic resonance native myocardial T1 mapping in patients with pulmonary hypertension. Journal of Cardiovascular Magnetic Resonance, 20. View this article in WRRO
- Spatial Comparison of CT-Based Surrogates of Lung Ventilation With Hyperpolarized Helium-3 and Xenon-129 Gas MRI in Patients Undergoing Radiation Therapy. International Journal of Radiation Oncology, Biology, Physics, 102(4), 1276-1286. View this article in WRRO
- Long-range heteronuclear J-coupling constants in esters: Implications for 13C metabolic MRI by side-arm parahydrogen-induced polarization. Journal of Magnetic Resonance, 296, 85-92. View this article in WRRO
- 129 Xe-Rb Spin-Exchange Optical Pumping with High Photon Efficiency. Physical Review Letters, 121(15). View this article in WRRO
- Ethyl pyruvate improves pulmonary function in mice with bleomycin-induced lung injury as monitored with hyperpolarized 129Xe MR imaging. Magnetic Resonance in Medical Sciences, 17(4), 331-337. View this article in WRRO
- Imaging Lung Function Abnormalities in Primary Ciliary Dyskinesia Using Hyperpolarized Gas Ventilation MRI. Annals of the American Thoracic Society, 15(12), 1487-1490. View this article in WRRO
- Comparison of 3 He and 129 Xe MRI for evaluation of lung microstructure and ventilation at 1.5T. Journal of Magnetic Resonance Imaging, 48(3), 632-642. View this article in WRRO
- 3D diffusion-weighted 129 Xe MRI for whole lung morphometry. Magnetic Resonance in Medicine, 79(6), 2986-2995. View this article in WRRO
- Imaging Human Brain Perfusion with Inhaled Hyperpolarized (129)Xe MR Imaging.. Radiology, 286(2). View this article in WRRO
- Treatment response of ethyl pyruvate in a mouse model of chronic obstructive pulmonary disease studied by hyperpolarized129Xe MRI. Magnetic Resonance in Medicine, 78(2), 721-729. View this article in WRRO
- Whole lung morphometry with 3D multiple b‐value hyperpolarized gas MRI and compressed sensing. Magnetic Resonance in Medicine, 77(5), 1916-1925. View this article in WRRO
- 129 Xe chemical shift in human blood and pulmonary blood oxygenation measurement in humans using hyperpolarized 129 Xe NMR. Magnetic Resonance in Medicine, 77(4), 1399-1408. View this article in WRRO
- Detection of early subclinical lung disease in children with cystic fibrosis by lung ventilation imaging with hyperpolarised gas MRI. Thorax, 72(8), 760-762. View this article in WRRO
- Hyperpolarized (13) C,(15) N2 -Urea MRI for assessment of the urea gradient in the porcine kidney.. Magnetic Resonance in Medicine, 76(6), 1895-1899. View this article in WRRO
- Finite element modeling of 129Xe diffusive gas exchange NMR in the human alveoli. Journal of Magnetic Resonance, 271, 21-33. View this article in WRRO
- Chronic Obstructive Pulmonary Disease: Lobar Analysis with Hyperpolarized (129)Xe MR Imaging.. Radiology, 152299-152299. View this article in WRRO
- Multiple breath washout of hyperpolarized (129) Xe and (3) He in human lungs with three-dimensional balanced steady-state free-precession imaging.. Magn Reson Med. View this article in WRRO
- Reproducibility of quantitative indices of lung function and microstructure from 129Xe chemical shift saturation recovery (CSSR) MR spectroscopy. Magnetic Resonance in Medicine. View this article in WRRO
- High resolution spectroscopy and chemical shift imaging of hyperpolarized 129Xe dissolved in the human brain in vivo at 1.5 tesla. Magnetic Resonance in Medicine, 75(6), 2227-2234. View this article in WRRO
- Observation of cardiogenic flow oscillations in healthy subjects with hyperpolarized 3 He MRI. Journal of Applied Physiology, 119(9), 1007-1014. View this article in WRRO
- Feasibility of human lung ventilation imaging using highly polarized naturally abundant xenon and optimized three-dimensional steady-state free precession. Magnetic Resonance in Medicine, 74(2), 346-352. View this article in WRRO
- Relaxation and exchange dynamics of hyperpolarized129Xe in human blood. Magnetic Resonance in Medicine, 74(2), 303-311.
- Experimental validation of the hyperpolarized 129 Xe chemical shift saturation recovery technique in healthy volunteers and subjects with interstitial lung disease. Magnetic Resonance in Medicine, 74(1), 196-207. View this article in WRRO
- Lung ventilation volumetry with same-breath acquisition of hyperpolarized gas and proton MRI. NMR in Biomedicine, 27(12), 1461-1467. View this article in WRRO
- Mapping the amplitude and phase of dissolved
129Xe red blood cell signal oscillations with keyhole spectroscopic lung imaging. Magnetic Resonance in Medicine. - Compressed sensing reconstruction for high‐
SNR , rapid dissolved129Xe gas exchangeMRI . Magnetic Resonance in Medicine. - A framework for modelling whole-lung and regional TLCOusing hyperpolarised129Xe lung MRI. ERJ Open Research, 00442-2024.
- Improving Xenon‐129 lung ventilation image SNR with deep‐learning based image reconstruction. Magnetic Resonance in Medicine.
- Age, sex, and lung volume dependence of dissolved xenon‐129 MRI gas exchange metrics. Magnetic Resonance in Medicine.
- A Framework for Predicting X-Nuclei Transmitter Gain Using 1H Signal. Tomography, 9(5), 1603-1616.
- Phase Contrast MRI of Inhaled Xenon Reveals the Relationship Between Airflow and Obstruction in OSA. American Journal of Respiratory and Critical Care Medicine.
- Hyperpolarized 13 C Magnetic Resonance Imaging of Fumarate Metabolism by Parahydrogen‐induced Polarization: A Proof‐of‐Concept in vivo Study. ChemPhysChem.
- Novel Imaging Techniques for Cystic Fibrosis Lung Disease. Pediatric Pulmonology.
- Measuring 129Xe transfer across the blood brain barrier using magnetic resonance spectroscopy. Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine.
Chapters
- Hyperpolarised Helium-3 (3He) MRI: Physical Methods for Imaging Human Lung Function, MRI of the Lung (pp. 69-97). Springer International Publishing
- MRI methods for structural and functional assessment of the lungs: proton and multinuclear, Imaging (pp. 1-19). European Respiratory Society View this article in WRRO
Conference proceedings papers
- P177 129Xe MRI phenotyping and longitudinal change in patients with asthma and/or COPD and normal pulmonary function tests. ‘You ain’t seen nothing yet’ – Imaging across COPD, nodules and lung cancer screening
- P176 Bronchodilator response discordance in patients with asthma and/or COPD assessed by 129Xe-MRI and spirometry. ‘You ain’t seen nothing yet’ – Imaging across COPD, nodules and lung cancer screening
- Xe-MRI bronchodilator response to assess disease severity in patients with asthma and/or COPD. Respiratory function technologists/scientists
- Bronchodilator response discordance in patients with asthma and/or COPD using Xe-MRI and spirometry. Respiratory function technologists/scientists
- Longitudinal change in lung physiology and 129Xe MRI over 1 year in patients with asthma and/or COPD. Clinical respiratory physiology, exercise and functional imaging
- Hyperpolarised 129Xe MR imaging of lung ventilation in neonates with bronchopulmonary dysplasia: initial experience. 14.02 - Imaging
- Measuring Airflow Velocity in the Upper Airway in Pediatric Patients with Obstructive Sleep Apnea via Phase Contrast MRI of Hyperpolarized Xenon. B29. EMERGING APPROACHES: TRANSLATING SLEEP APNEA ENDOTYPES INTO CLINICAL PRACTICE (pp a2564-a2564)
- Initial Experience with Hyperpolarized Xenon-129 Gas MRI in Neonates with Bronchopulmonary Dysplasia. C51. TRACHEOSTOMIES AND BPD (pp a4356-a4356)
- In Vivo Validation of Computational Fluid Dynamics Simulations of Upper-Airway Respiratory Airflow with 129Xe Phase Contrast MRI. TP122. TP122 NOVEL IMAGING METHODS AND APPLICATIONS
- Probing diffusion and perfusion in idiopathic pulmonary fibrosis with hyperpolarised xenon and dynamic contrast-enhanced magnetic resonance imaging. Thorax, Vol. 73(Suppl 4) (pp A44-A45). London, UK, 5 December 2018 - 7 December 2018. View this article in WRRO
- OC-0182: A comparison of CT ventilation with 3He and 129Xe MRI for functional avoidance treatment planning. Radiotherapy and Oncology, Vol. 127(Supplement 1) (pp S96-S97). Barcelona, Spain, 20 April 2018 - 24 April 2018. View this article in WRRO
- Longitudinal monitoring of lung microstructure with HP gas diffusion-weighted MRI in mild cystic fibrosis children. Cystic Fibrosis View this article in WRRO
- Ventilation heterogeneity assessed in patients with mild cystic fibrosis and asthma using Hyperpolarised gas MRI histogram analysis. Imaging
- Late breaking abstract - Hyperpolarised gas MRI demonstrates sub-clinical progression in IPF over 6 months. European Respiratory Journal, Vol. 50(Suppl 61). Milan, Italy, 9 September 2017 - 13 September 2017. View this article in WRRO
- Regional phase III slope measurement using hyperpolarized gas MR imaging. 1.3 Imaging View this article in WRRO
- Native myocardial T1 correlates with right ventricular remodelling in patients with pulmonary hypertension. 4.3 Pulmonary Circulation and Pulmonary Vascular Diseases
- Comparison of 3 He and 129 Xe MRI for evaluation of lung microstructure and ventilation at 1.5 T. European Respiratory Journal, Vol. 48(suppl 60), 3 September 2016 - 7 September 2016. View this article in WRRO
- Ventilation CT : voxel-level comparison with HP gas MRI. European Respiratory Journal, Vol. 48(Suppl 60). Estoril, Portugal, 10 March 2016 - 13 March 2016. View this article in WRRO
- Diffusion-weighted hyperpolarised gas MRI in idiopathic pulmonary fibrosis : reproducibility and clinical significance. ERS International Congress 2016 abstracts, Vol. 48(Suppl 60). London, UK, 3 September 2016 - 7 September 2016. View this article in WRRO
- WE-AB-202-07: Ventilation CT: Voxel-Level Comparison with Hyperpolarized Helium-3 & Xenon-129 MRI. Medical Physics, Vol. 43(6) (pp 3795-3796), 31 July 2016 - 4 August 2016. View this article in WRRO
- P283 Hyperpolarised Gas MRI – a pathway to Clinical Diagnostic Imaging. Thorax, Vol. 70(Suppl 3) (pp A220.3-A221)
- P286 Correlations of functional multi-nuclear MR imaging indices with pulmonary function tests in the assessment of idiopathic pulmonary fibrosis. Thorax, Vol. 70(Suppl 3) (pp A223.1-A223)
- Myocardial T1 mapping MRI in patients with PH and age-matched healthy volunteers. 4.3 Pulmonary Circulation and Pulmonary Vascular Disease
- Multi nuclear 3D multiple breath washout imaging with hyperpolarised3He and129Xe MRI. 1.3 Imaging
- Hyperpolarised gas MR lung imaging – Breaks through to clinical practice. 1.3 Imaging
- Repeatability of129Xe MR methods for quantification of interstitial thickness. 4.1 Clinical respiratory physiology, exercise and functional imaging
- Assessment of lung microstructure in ILD with3He and129Xe MRI. 4.1 Clinical respiratory physiology, exercise and functional imaging
- P273 Assessment Of Lung Microstructure In Interstitial Lung Disease With Hyperpolarised Gas Mri. Thorax, Vol. 69(Suppl 2) (pp A192-A193)
- Age-dependent changes in whole-lung septal thickness measured by Xe-129 MRI: A comparison of healthy volunteers and subjects with IPF. EUROPEAN RESPIRATORY JOURNAL, Vol. 44
- Age-dependent changes in whole-lung septal thickness measured by Xe-129 MRI: A comparison of healthy volunteers and subjects with IPF. EUROPEAN RESPIRATORY JOURNAL, Vol. 44
- Feasibility of high quality lung MRI with naturally abundant hyperpolarised Xe-129. EUROPEAN RESPIRATORY JOURNAL, Vol. 44
- Dissolved 129xe Mri - Delayed Gas Uptake Indicates Septal Thickening In Patients With Idiopathic Pulmonary Fibrosis And Systemic Sclerosis. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 189
- Improving Xenon-129 Lung Ventilation Image Quality with a Commercial Deep-Learning Based Image Reconstruction. ISMRM Annual Meeting, 3 June 2023 - 8 June 2023.
- Implementation of dissolved 129Xe lung MRI with 4-echo 3D radial spectroscopic imaging at 3T: comparing with results at 1.5T in healthy volunteers. ISMRM Annual Meeting, 3 June 2023 - 8 June 2023.
- 129Xe gas transfer lung MRI before and after bronchodilator inhalation in patients with asthma and/or COPD. ISMRM Annual Meeting, 3 June 2023 - 8 June 2023.
- Longitudinal 129Xe MRI assessment of lung gas transfer and microstructure over 1 year in patients with asthma and/or COPD. ISMRM Annual Meeting, 3 June 2023 - 8 June 2023.
- Batch-mode production of hyperpolarised xenon gas with a continuous-flow polariser for preclinical and clinical human lung ventilation images. ISMRM Annual Meeting, 3 June 2023 - 8 June 2023.
- Modelling Whole-Lung and Regional Carbon Monoxide Transfer Factor with Hyperpolarized 129Xe MRI in Asthma and COPD Patients. ISMRM Annual Meeting, 3 July 2023 - 8 July 2023.
- Age and lung volume dependence of dissolved xenon-129 imaging parameters. ISMRM Annual Meeting, 7 May 2022 - 12 May 2022.
- Improving Efficiency of Ultra-short Echo Time MRI in Neonatal Lungs with a FLORET Spiral Trajectory. ISMRM Annual Meeting, 7 May 2022 - 12 May 2022.
- Longitudinal comparison of quantitative UTE lung MRI and CT biomarkers in interstitial lung disease. ISMRM Annual Meeting, 7 May 2022 - 12 May 2022.
- Hyperpolarized 129Xe MR Imaging in Neonates with Bronchopulmonary Dysplasia: Feasibility and Challenges. ISMRM Annual Meeting, 7 May 2022 - 12 May 2022.
- Measuring Airflow Velocity in the Upper Airways with 129Xe Phase Contrast MRI: Feasibility in Pediatric Patients with Obstructive Sleep Apnea. ISMRM Annual Meeting, 7 May 2022 - 12 May 2022.
Preprints
- Longitudinal lung function assessment of patients hospitalised with COVID-19 using 1H and 129Xe lung MRI, Cold Spring Harbor Laboratory.