Professor Michael J Cork
BSc MB PhD FRCP
School of Medicine and Population Health
Professor of Dermatology
Full contact details
School of Medicine and Population Health
The Medical School
Beech Hill Road
Sheffield
S10 2RX
- Profile
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For enquiries please contact - SMPH-West-Operational@sheffield.ac.uk
I joined the University of Sheffield in 1991 as a lecturer in dermatology whilst continuing as a practising dermatologist for the NHS in Sheffield. I had previously been a Registrar in Dermatology at the Royal Hallamshire Hospital, Sheffield, and before that a Registrar in Respiratory General Medicine at Leeds General Infirmary.
I have been closely involved with research in many areas of dermatology; including Atopic Eczema(dermatitis), Psoriasis, Vitiligo and the Genetics of Skin Disease. My major current research work is aimed at identifying gene–environment interactions in the development of atopic dermatitis leading to skin barrier breakdown and the understanding of how topical agents interact with the skin barrier; using this information to enhance the treatment of atopic dermatitis.
I am currently Head of Sheffield Dermatology Research in the School of Medicine & Population Health at the University of Sheffield and am Honorary Consultant Dermatologist to both Sheffield Children´s Hospital NHS Foundation Trust and to Sheffield Teaching Hospitals NHS Foundation Trust; my time is evenly split between the University and the NHS.
- Research interests
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My research interests are inflammatory skin disorders including: atopic dermatitis (atopic eczema), psoriasis, alopecia areata and vitiligo. The group which includes both clinical and non-clinical staff has identified genetic variants associated with all of these diseases.
Internationally, Sheffield Dermatology Research is one of the leading groups translating basic dermatological science into new treatments for the clinic. Examples include `Skin Protease Inhibitors´ and `Vitamin A Metabolic Pathway Inhibitors´. In 2001, with help from The Wellcome Trust, the group formed a `spin-out´ company called `Molecular SkinCare´, with the aim of developing these treatments.
Another major focus of the group is the effect of topical pharmaceuticals, cosmetics and oils on the structure and function of the skin barrier. Research in this area comprises investigation of the skin barrier defect associated with skin disorders such as atopic dermatitis, how skin barrier defects develop and how to treat or repair the skin barrier defect. This includes the determination of the effect of topical agents/products on the skin of volunteers visiting our clinical diagnostic `skin laboratory´, where we can measure specific properties of the skin barrier, non-invasively, using an array of specialised equipment. These results are then correlated with variants in the genes that determine the structure and function of the skin barrier.
Research conducted by Sheffield Dermatology Research is at the interface between the clinic, academia and industry. Work has been funded by charities, including: The Wellcome Trust, British Skin Foundation and Psoriasis Association; also by the Kuwait Ministry of Health; and by pharmaceutical/cosmetics companies; including Astellas, Johnson & Johnson and Stiefel-GSK.
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- Dupilumab safety and efficacy up to 1 Year in children aged 6 months to 5 years with atopic dermatitis: results from a phase 3 open-label extension study. American Journal of Clinical Dermatology, 25(4), 655-668. View this article in WRRO
- Dupilumab in children aged 6 months to younger than 6 years with uncontrolled atopic dermatitis: a randomised, double-blind, placebo-controlled, phase 3 trial. The Lancet, 400(10356), 908-919.
- Daily emollient during infancy for prevention of eczema: the BEEP randomised controlled trial. The Lancet, 395(10228), 962-972.
- Dupilumab in adolescents with uncontrolled moderate‐to‐severe atopic dermatitis : results from a phase IIa open‐label trial and subsequent phase III open‐label extension. British Journal of Dermatology, 182(1), 85-96.
- Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis.. The New England Journal of Medicine. View this article in WRRO
- Development of stratum corneum chymotrypsin-like protease activity and natural moisturising factors from birth to 4 weeks of age compared to adults.. British Journal of Dermatology, 175(4), 713-720. View this article in WRRO
- The effect of an emollient containing urea, ceramide NP, and lactate on skin barrier structure and function in older people with dry skin. Skin Pharmacology and Physiology. View this article in WRRO
- Olive Oil, Sunflower Oil or no Oil for Baby Dry Skin or Massage: A Pilot, Assessor-blinded, Randomized Controlled Trial (the Oil in Baby SkincaRE [OBSeRvE] Study). Acta Dermato Venereologica, 96(3), 323-330.
- Comparing the Effect of a Twice-weekly Tacrolimus and Betamethasone Valerate Dose on the Subclinical Epidermal Barrier Defect in Atopic Dermatitis. Acta Dermato Venereologica, 95(6), 653-658.
- Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention. Journal of Allergy and Clinical Immunology, 134(4), 818-823.
- The effect of tacrolimus compared with betamethasone valerate on the skin barrier in volunteers with quiescent atopic dermatitis.. Br J Dermatol, 170(4), 914-921.
- Randomized, Controlled Trial Evaluating a Baby Wash Product on Skin Barrier Function in Healthy, Term Neonates. JOGNN - Journal of Obstetric, Gynecologic, and Neonatal Nursing.
- Topical treatments for chronic plaque psoriasis. Cochrane Database Syst Rev..
- Effect of olive and sunflower seed oil on the adult skin barrier: implications for neonatal skin care.. Pediatr Dermatol, 30(1), 42-50.
- The effect of aqueous cream BP on the skin barrier in volunteers with a previous history of atopic dermatitis.. Br J Dermatol, 165(2), 329-334.
- Epidermal barrier dysfunction in atopic dermatitis.. J Invest Dermatol, 129(8), 1892-1908.
Book chapters
- Neonatal Skin Care and Toxicology In Eichenfield LF, Frieden IJ, Zaenglein A & Mathes E (Ed.), Neonatal and Infant Dermatology (pp. 46-56). Saunders
- The Skin Barrier in Atopic Dermatitis. In Irvine A, Hoeger P & Yan A (Ed.), Textbook of Pediatric Dermatology, UK: Blackwell Publishing Ltd..
Reports
All publications
Journal articles
- Internationale Umfrage zur Behandlungspraktiken bei atopischer Dermatitis bei schwangeren und stillenden Frauen: Perspektiven von Ärzten. JDDG: Journal der Deutschen Dermatologischen Gesellschaft, 23(9), 1116-1125.
- The skin sensitization prediction model: an algorithm for real-world prediction of skin sensitization risk and minimization of human sensitization testing.. Regul Toxicol Pharmacol, 105941.
- 64775 Integrated Safety Update of Abrocitinib in 1014 Young Adult Patients Aged 18 to <40 Years With Moderate-to-Severe Atopic Dermatitis: Data From More Than 2250 Patient-Years With up to 4.5 Years of Exposure. Journal of the American Academy of Dermatology, 93(3), ab234.
- 62960 Dupilumab Safety and Efficacy Up To 3 Years In Children Aged 6 Months to 11 Years With Atopic Dermatitis. Journal of the American Academy of Dermatology, 93(3), ab178.
- 62286 Baseline Growth Analysis of Children and Adolescents With Moderate-to-Severe Atopic Dermatitis Enrolled in Phase 3 Dupilumab Trials. Journal of the American Academy of Dermatology, 93(3), ab22.
- 62057 Growth Analysis in Children 6-11 Years with Severe Atopic Dermatitis and Impact of up to 52 Weeks of Dupilumab on Height. Journal of the American Academy of Dermatology, 93(3), ab49.
- 61982 Dupilumab normalizes filaggrin processing and improves clinical outcomes in children with moderate-to-severe atopic dermatitis. Journal of the American Academy of Dermatology, 93(3), ab178.
- 0490 Proteomic analysis reveals sustained improvements in skin composition in pediatric patients treated with dupilumab. Journal of Investigative Dermatology, 145(8), S84-S84.
- BG04 (P063) Marked changes in the skin lipidome as we age are associated with reduced skin barrier function and can be rescued by topical therapy with physiologic lipids. British Journal of Dermatology, 193(Supplement_1).
- P063 Marked changes in the skin lipidome as we age are associated with reduced skin barrier function and can be rescued by topical therapy with physiologic lipids. British Journal of Dermatology, 193(Supplement_1).
- International survey of treatment practices for atopic dermatitis in pregnant and breastfeeding women: Physician perspectives. JDDG: Journal der Deutschen Dermatologischen Gesellschaft. View this article in WRRO
- Efficacy and safety of dupilumab in pediatric patients aged 6 months to 11 years with erythrodermic atopic dermatitis: A post-hoc analysis of three clinical trials. Journal of the American Academy of Dermatology.
- Topical supplementation with physiological lipids rebalances the stratum corneum ceramide profile and strengthens skin barrier function in adults predisposed to atopic dermatitis. British Journal of Dermatology, 193(4), 729-740. View this article in WRRO
- Is colloidal oat an effective emollient ingredient for the prevention and treatment of atopic dermatitis in infants?. Journal of Dermatological Treatment, 36(1), 2487945.
- Exposure–response of ciclosporin and methotrexate in children and young people with severe atopic dermatitis: A secondary analysis of the TREatment of severe Atopic dermatitis Trial (TREAT). Clinical and Experimental Dermatology. View this article in WRRO
- Long-term safety of abrocitinib in moderate-to-severe atopic dermatitis: integrated analysis by age. The Journal of Allergy and Clinical Immunology: In Practice, 13(5), 1164-1175.e2. View this article in WRRO
- 117: Long-term efficacy of tralokinumab in adolescents with moderate-to-severe atopic dermatitis. Journal of Investigative Dermatology, 145(3), e29-e29.
- 114: Dupilumab Efficacy and Safety up to 2 Years in Children Aged 6 Months to 5 Years with Atopic Dermatitis. Journal of Investigative Dermatology, 145(3), e28-e28.
- 112: Laboratory parameters in adolescent patients aged 12-17 with moderate-to-severe atopic dermatitis treated with tralokinumab up to Week 52: results from the phase 3 ECZTRA 6 trial. Journal of Investigative Dermatology, 145(3), e27-e27.
- 105: Growth Analysis at Baseline in Children and Adolescents with Moderate-to-Severe Atopic Dermatitis Enrolled in Phase 3 Dupilumab Trials. Journal of Investigative Dermatology, 145(3), e26-e26.
- Pediatric Atopic Dermatitis is Associated With More Rapid Recovery of Protein Bound Ceramides After Treatment With Dupilumab. Journal of Allergy and Clinical Immunology, 155(2), AB203-AB203.
- Growth Analysis in Children Aged 6 to 11 Years and Adolescents Aged 12 to 17 Years With Moderate-To-Severe Atopic Dermatitis and Impact of 16 Weeks of Dupilumab Treatment on Height. Journal of Allergy and Clinical Immunology, 155(2), AB208-AB208.
- Dupilumab Treatment Improves Lichenification in Atopic Dermatitis in Different Age and Racial Groups.. Journal of drugs in dermatology : JDD, 24(2), 167-173.
- The effect of dupilumab on caregiver- and patient-reported outcomes in young children with moderate-to-severe atopic dermatitis: results from a placebo-controlled, phase 3 study. Journal of the American Academy of Dermatology, 92(1), 116-126. View this article in WRRO
- Refractory pyoderma gangrenosum in Caucasian adolescent with Takayasu arteritis and life‐threatening infections. JEADV Clinical Practice, 4(1), 234-239. View this article in WRRO
- Les enfants atteints de dermatite atopique répondent plus rapidement au traitement par dupilumab que les adolescents et les adultes. Annales de Dermatologie et de Vénéréologie - FMC, 4(8), A205-A206.
- Efficacité en vie réelle du tralokinumab chez les adultes atteints de dermatite atopique : résultats intermédiaires sur l’amélioration de la sévérité de la maladie évaluée par le médecin après un suivi allant jusqu’à 9 mois dans l’étude TRACE. Annales de Dermatologie et de Vénéréologie - FMC, 4(8), A370-A371.
- Durable improvements in atopic dermatitis in the head and neck and across other anatomic regions with rocatinlimab. Archives of Dermatological Research, 316(10). View this article in WRRO
- LONG-TERM EFFICACY OF ABROCITINIB AS MONOTHERAPY OVER 96 WEEKS IN THE JADE CLINICAL PROGRAM. Annals of Allergy, Asthma & Immunology, 133(6), S100-S100.
- DUPILUMAB TREATMENT IMPROVES ATOPIC DERMATITIS SIGNS ACROSS ANATOMICAL REGIONS IN PATIENTS AGED 12–17 YEARS. Annals of Allergy, Asthma & Immunology, 133(6), S96-S97.
- Practicality, Validity and Responsiveness of Using the Proxy Version of the CHU-9D with Children Aged 2 to 5 Years. Value in Health, S1098-3015(24)02861.
- A Practical Guide to Using Oral JAK Inhibitors for Atopic Dermatitis from the International Eczema Council. British Journal of Dermatology, ljae342.
- 52650 Dupilumab Treatment Shows Rapid and Consistent Improvement in Atopic Dermatitis in All Anatomical Regions in Patients Aged 6 Months to 17 Years: Results From an Open-Label Extension Study. Journal of the American Academy of Dermatology, 91(3), AB189-AB189.
- 52909 MOISTURIZER WITH SKIN IDENTICAL LIPIDS RESTORES BARRIER FUNCTION IN ECZMEA-PRONE SKIN AND REDUCES SKIN SUSCEPTIBILITY TO IRRITANTS. Journal of the American Academy of Dermatology, 91(3), AB259-AB259.
- 53081 Dupilumab Treatment Provides Sustained Improvement in Skin Barrier Function, Clinical Outcomes, and Patient-Reported Outcomes in Patients Aged 6 to 11 Years With Moderate-to-Severe Atopic Dermatitis. Journal of the American Academy of Dermatology, 91(3), AB34-AB34.
- 52273 Dupilumab Provides Sustained Normalization of Skin Barrier Function in Children With Moderate-to-Severe Atopic Dermatitis. Journal of the American Academy of Dermatology, 91(3), AB34-AB34.
- 51363 Growth Analysis in Children Aged Less Than 12 Years with Moderate-to-Severe Atopic Dermatitis. Journal of the American Academy of Dermatology, 91(3), AB1-AB1.
- Effects of a pH-Regulating Emollient Cream in Mild Atopic Dermatitis Patients with Moderate Localized Lesions. Skin Pharmacology and Physiology, 1-10.
- 280 Children with atopic dermatitis respond more rapidly to dupilumab treatment in comparison to adolescents and adults. Journal of Investigative Dermatology, 144(8), S48-S48.
- Pharmacokinetics and pharmacodynamics of itepekimab in adults with moderate‐to‐severe atopic dermatitis: Results from two terminated phase II trials. Clinical and Translational Science, 17(8).
- A prospective observational cohort study comparing the treatment effectiveness and safety of ciclosporin, dupilumab and methotrexate in adult and paediatric patients with atopic dermatitis: results from the UK-Irish A-STAR register. British Journal of Dermatology, 191(6), 988-999. View this article in WRRO
- The effects of ciclosporin and methotrexate on kidney function in the treatment of severe atopic dermatitis in children – results from the TREAT trial. British Journal of Dermatology, 191(5), 851-852. View this article in WRRO
- P086 The UK-Irish Atopic Eczema Systemic TherApy Register (A-STAR): baseline characteristics of the cohort. British Journal of Dermatology, 191(Supplement_1), i55-i56.
- P097 ‘Real-world’ Janus kinase inhibitor treatments in the UK-Irish A-STAR register: cohort profile and treatment outcomes. British Journal of Dermatology, 191(Supplement_1), i61-i62.
- P036 Dupilumab treatment normalizes skin barrier function in children aged 6–11 years with moderate-to-severe atopic dermatitis. British Journal of Dermatology, 191(Supplement_1), i30-i30.
- O03 Comparing the treatment effectiveness and safety of ciclosporin, dupilumab and methotrexate in adult and paediatric patients with atopic eczema: results from the UK-Irish A-STAR register. British Journal of Dermatology, 191(Supplement_1), i2-i3.
- Dupilumab safety and efficacy up to 1 Year in children aged 6 months to 5 years with atopic dermatitis: results from a phase 3 open-label extension study. American Journal of Clinical Dermatology, 25(4), 655-668. View this article in WRRO
- Long-term laboratory safety of dupilumab in patients aged 6 months to 5 years with moderate-to-severe atopic dermatitis. Revue Française d'Allergologie, 64, 104044-104044.
- 549 - Laboratory parameters in adolescent patients aged 12–17 with moderate-to-severe atopic dermatitis treated with tralokinumab up to week 52: results from the phase 3 ECZTRA 6 trial. British Journal of Dermatology, 190(Supplement_2), ii47-ii48.
- Dupilumab Improves Skin Lipid Barrier in Pediatric Patients With Moderate-to-Severe Atopic Dermatitis. Journal of Allergy and Clinical Immunology, 153(2), AB5-AB5.
- Adapting non-parametric spline representations of outdoor air pollution health effects associations for use in public health benefits assessment. Air Quality, Atmosphere & Health, 17(6), 1295-1305.
- Efficacy and safety of 308-nm Excimer lamp combined with Tacrolimus 0.1% ointment vs Tacrolimus 0.1% ointment as monotherapy in treating children with limited vitiligo: a randomized controlled trial. Journal of Dermatological Treatment, 35(1). View this article in WRRO
- Association between skin barrier development and early-onset atopic dermatitis: a longitudinal birth cohort study. Journal of Allergy and Clinical Immunology, 153(3), 732-741.e8. View this article in WRRO
- Tralokinumab provides clinically meaningful responses at week 16 in adults with moderate-to-severe atopic dermatitis who do not achieve IGA 0/1. American Journal of Clinical Dermatology, 25, 139-148. View this article in WRRO
- Tolérance et efficacité à long terme du tralokinumab chez des adolescents atteints de dermatite atopique modérée à sévère : analyse intermédiaire d’ECZTEND. Annales de Dermatologie et de Vénéréologie - FMC, 3(8), A363-A364.
- Dupilumab safety and efficacy in a phase III open-label extension trial in children 6–11 years of age with severe atopic dermatitis. Dermatology and Therapy, 13, 2697-2719. View this article in WRRO
- Efficacy and safety of ciclosporin versus methotrexate in the treatment of severe atopic dermatitis in children and young people (TREAT): a multicentre parallel group assessor-blinded clinical trial. British Journal of Dermatology, 189(6), 674-684. View this article in WRRO
- A concept for integrated care pathways for atopic dermatitis—A GA2LEN ADCARE initiative. Clinical and Translational Allergy, 13(9). View this article in WRRO
- Emollients for preventing atopic eczema: cost‐effectiveness analysis of the BEEP trial. Clinical & Experimental Allergy, 53(10), 1011-1019. View this article in WRRO
- Dupilumab Treatment Leads to Rapid and Consistent Improvement of Atopic Dermatitis in All Anatomical Regions in Patients Aged 6 Months to 5 Years. Dermatology and Therapy, 13(9), 1987-2000. View this article in WRRO
- Safety and efficacy of amlitelimab, a fully human nondepleting, noncytotoxic anti-OX40 ligand monoclonal antibody, in atopic dermatitis: results of a phase IIa randomized placebo-controlled trial. British Journal of Dermatology, 189(5), 531-539. View this article in WRRO
- Potential application of PS-OCT in the safety assessment of non-steroidal topical creams for atopic dermatitis treatment. Biomedical Optics Express, 14(8), 4126-4136. View this article in WRRO
- Efficacy and Safety of Tralokinumab in Adolescents With Moderate to Severe Atopic Dermatitis. JAMA Dermatology, 159(6), 596-596.
- Dupilumab provides clinically meaningful responses in children aged 6–11 years with severe atopic dermatitis: post hoc analysis results from a phase III trial. American Journal of Clinical Dermatology, 24(5), 787-798. View this article in WRRO
- Are mild cleansers appropriate for hand hygiene in the COVID era? An in vitro investigation of the antiviral efficacy of different hand hygiene products. Frontiers in Virology, 3. View this article in WRRO
- Efficacy and safety of abrocitinib in patients with severe and/or difficult-to-treat atopic dermatitis: a post hoc analysis of the randomized phase 3 JADE COMPARE trial. American Journal of Clinical Dermatology, 24, 609-621. View this article in WRRO
- Dupilumab improves patient-reported symptoms and health-related quality of life in children aged 6–11 years with severe atopic dermatitis. British Journal of Dermatology, 189(2), 238-240. View this article in WRRO
- Efficacy and safety of abrocitinib monotherapy in adolescents and adults: a post hoc analysis of the phase 3 JAK1 atopic dermatitis efficacy and safety (JADE) REGIMEN clinical trial. Journal of Dermatological Treatment, 34(1). View this article in WRRO
- Early improvements in signs and symptoms predict clinical response to baricitinib in patients with moderate-to-severe atopic dermatitis. Clinical and Experimental Dermatology, 48(8), 881-888. View this article in WRRO
- Dupilumab treatment reduces total IgE levels in patients 6 months and older with moderate-to-severe atopic dermatitis. Revue Française d'Allergologie, 63(3), 103434-103434.
- Dupilumab treatment in children aged 6–11 years with severe atopic dermatitis is associated with reductions in serum immunoglobulin E and thymus and activation-regulated chemokine levels. Revue Française d'Allergologie, 63(3), 103436-103436.
- Developing integrated care pathways for atopic dermatitis—challenges and unmet needs. Clinical and Translational Allergy, 13(3).
- Efficacy and Safety of Dupilumab in Patients With Erythrodermic Atopic Dermatitis. JAMA Dermatology, 159(3), 255-255.
- Targeting skin barrier function in atopic dermatitis. The Journal of Allergy and Clinical Immunology: In Practice, 11(5), 1335-1346. View this article in WRRO
- Supplement Individual Article: The Importance of a Healthy Skin Barrier From the Cradle to the Grave Using Ceramide-Containing Cleansers and Moisturizers: A Review and Consensus. Journal of Drugs in Dermatology Jdd, 22(2), s3-SF344607.
- Dupilumab Treatment Reduces Total IgE Levels in Patients 6 Months and Older with Moderate-to-Severe Atopic Dermatitis. Journal of Allergy and Clinical Immunology, 151(2), AB149-AB149.
- The Importance of a Healthy Skin Barrier From the Cradle to the Grave Using Ceramide-Containing Cleansers and Moisturizers: A Review and Consensus. JOURNAL OF DRUGS IN DERMATOLOGY, 22(2), S3-S14.
- Laboratory safety from a randomized 16-week phase III study of dupilumab in children aged 6 months to 5 years with moderate-to-severe atopic dermatitis. Pediatric Drugs, 25, 67-77.
- A real‐world retrospective observational study exploring NHS resource use in England for the management of moderate‐to‐severe atopic dermatitis in secondary care for children and adolescents. Pediatric Dermatology, 40(1), 50-63.
- Skin care interventions in infants for preventing eczema and food allergy. Cochrane Database of Systematic Reviews, 2022(11). View this article in WRRO
- Real-Time Infrared spectroscopic measurement of natural moisturising factor. Journal of Investigative Dermatology, 143(4), 676-679.e5. View this article in WRRO
- Efficacité et tolérance de l’abrocitinib selon le poids corporel : analyse poolée de 3 essais cliniques randomisés. Annales de Dermatologie et de Vénéréologie - FMC, 2(8), A342-A343.
- Résultats d’abrocitinib chez les patients atteints de dermatite atopique et d’asthme : analyse de l’essai JADE REGIMEN. Annales de Dermatologie et de Vénéréologie - FMC, 2(8), A335-A336.
- Emollients for prevention of atopic dermatitis; 5‐year findings from the BEEP randomised trial. Allergy.
- Dupilumab in children aged 6 months to younger than 6 years with uncontrolled atopic dermatitis: a randomised, double-blind, placebo-controlled, phase 3 trial. The Lancet, 400(10356), 908-919.
- Long-term efficacy and safety of dupilumab in adolescents with moderate-to-severe atopic dermatitis : results through week 52 from a phase III open-label extension trial (LIBERTY AD PED-OLE). American Journal of Clinical Dermatology, 23(3), 365-383.
- Type 2 inflammation contributes to skin barrier dysfunction in atopic dermatitis. JID Innovations, 2(5).
- Different types of emollient cream exhibit diverse physiological effects on the skin barrier in adults with atopic dermatitis. Clinical and Experimental Dermatology, 47(6), 1154-1164. View this article in WRRO
- Efficacy and safety of dupilumab in children aged 6–11 years with inadequately controlled severe atopic dermatitis: Results from an open-label extension trial up to 1 year. Revue Française d'Allergologie, 62(3), 321-321.
- Moisturizer therapy in prevention of atopic dermatitis and food allergy: to use or disuse?. Annals of Allergy, Asthma & Immunology, 128(5), 512-525. View this article in WRRO
- Infections in children and adolescents treated with dupilumab in pediatric clinical trials for atopic dermatitis—a pooled analysis of trial data. Pediatric Dermatology, 39(2), 187-196. View this article in WRRO
- Enhancement of stratum corneum lipid structure improves skin barrier function and protects against irritation in adults with dry, eczema‐prone, skin. British Journal of Dermatology, 186(5), 875-886. View this article in WRRO
- Randomized controlled pilot trial with ion‐exchange water softeners to prevent eczema (SOFTER trial). Clinical & Experimental Allergy, 52(3), 405-415. View this article in WRRO
- Impact of oral abrocitinib on signs, symptoms and quality of life among adolescents with moderate‐to‐severe atopic dermatitis : an analysis of patient‐reported outcomes. Journal of the European Academy of Dermatology and Venereology, 36(3), 422-433.
- Proposal of 0.5 mg of protein/100 g of processed food as threshold for voluntary declaration of food allergen traces in processed food—A first step in an initiative to better inform patients and avoid fatal allergic reactions: A GA²LEN position paper. Allergy, 77(6), 1736-1750.
- Vehicles for atopic dermatitis therapies: more than just a placebo. Journal of Dermatological Treatment, 33(2), 685-698.
- Response to: Letter to the Editor Regarding “An Investigation of the Skin Barrier Restoring Effects of a Cream and Lotion Containing Ceramides in a Multi-Vesicular Emulsion in People with Dry, Eczema-Prone, Skin: The RESTORE Study Phase 1”. Dermatology and Therapy, 11(6), 2249-2252. View this article in WRRO
- Impact de l’abrocitinib sur les démangeaisons, le sommeil, la douleur cutanée et le stress psychologique chez les patients présentant une dermatite atopique modérée à sévère : analyse poolée des essais JADE en monothérapie. Annales de Dermatologie et de Vénéréologie - FMC, 1(8), A345-A346.
- Impact de l’abrocitinib sur la réponse vaccinale chez les adolescents présentant une dermatite atopique modérée à sévère recevant les vaccins courants contre la diphtérie, la coqueluche et le tétanos dans l’étude de phase III JADE TEEN. Annales de Dermatologie et de Vénéréologie - FMC, 1(8), A354-A355.
- Induction par l’abrocitinib, arrêt de la thérapie et récupération de l’efficacité par traitement de secours chez les adolescents présentant une dermatite atopique modérée à sévère : analyse post-hoc de l’étude de phase 3 JADE-REGIMEN (NCT036227767). Annales de Dermatologie et de Vénéréologie - FMC, 1(8), A348-A348.
- D040 INFECTIONS IN DUPILUMAB PEDIATRIC CLINICAL TRIALS IN ATOPIC DERMATITIS (AD) — A POOLED ANALYSIS. Annals of Allergy, Asthma & Immunology, 127(5), S16-S17.
- P193 DUPILUMAB DECREASES TOTAL AND ALLERGEN-SPECIFIC IGE IN ADOLESCENTS WITH MODERATE-TO-SEVERE ATOPIC DERMATITIS (AD). Annals of Allergy, Asthma & Immunology, 127(5), S54-S55.
- P190 ABROCITINIB EFFICACY AND SAFETY BY BODY WEIGHT: POOLED ANALYSIS OF 3 RANDOMIZED CLINICAL TRIALS. Annals of Allergy, Asthma & Immunology, 127(5), S53-S54.
- Dupilumab demonstrates rapid and consistent improvement in extent and signs of atopic dermatitis across all anatomical regions in pediatric patients 6 years of age and older. Dermatology and Therapy, 11, 1643-1656.
- Dupilumab significantly modulates pain and discomfort in patients with atopic dermatitis : a post hoc analysis of 5 randomized clinical trials. Dermatitis, 32(1S), S81-S91.
- Efficacy and safety of crisaborole in patients with mild-to-moderate atopic dermatitis and other atopic comorbidities. Allergy and Asthma Proceedings, 42(5), 425-431.
- Laboratory safety of dupilumab in patients aged 6–11 years with severe atopic dermatitis : results from a phase III clinical trial. Pediatric Drugs, 23(5), 515-527.
- Priority research questions in atopic dermatitis : an International Eczema Council eDelphi consensus. British Journal of Dermatology, 185(1), 203-205. View this article in WRRO
- Imaging striae distensae : a comparison between PS-OCT and digital dermoscopy. Biomedical Optics Express, 12(6), 3296-3311.
- Dupilumab provides favourable long‐term safety and efficacy in children aged ≥ 6 to < 12 years with uncontrolled, severe atopic dermatitis: results from an open‐label phase IIa study and subsequent phase III open‐label extension study. British Journal of Dermatology, 184(5), 857-870.
- Treatment outcomes of patients with atopic dermatitis (AD) treated with dupilumab through the early access to medicines scheme (EAMS) in the UK. Ulster Medical Journal, 90(2), 70-76.
- Risk of severe allergic reactions to COVID-19 vaccines among patients with allergic skin diseases - practical recommendations. A position statement of ETFAD with external experts.. Journal of the European Academy of Dermatology and Venereology, 35(6), e362-e365.
- A predictive self-organizing multicellular computational model of infant skin permeability to topically applied substances. Journal of Investigative Dermatology, 141(8), 2049-2055.e1.
- Skincare interventions in infants for preventing eczema and food allergy: A cochrane systematic review and individual participant data meta‐analysis. Clinical & Experimental Allergy, 51(3), 402-418.
- Tralokinumab for moderate‐to‐severe atopic dermatitis: results from two 52‐week, randomized, double‐blind, multicentre, placebo‐controlled phase III trials (ECZTRA 1 and ECZTRA 2). British Journal of Dermatology, 184(3), 437-449.
- European Task Force on Atopic Dermatitis (ETFAD): position on vaccination of adult patients with atopic dermatitis against COVID‐19 (SARS‐CoV‐2) being treated with systemic medication and biologics. Journal of the European Academy of Dermatology and Venereology, 35(5), e308-e311.
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- The regulation of the haematopoietic stem cell compartment in foetal liver.. Progress in Clinical and Biological Research, 59 B, 277-285.
- Regulation of the growth fraction of CFU-S by an inhibitor produced by bone marrow. Leukemia Research, 5(1), 101-105.
- The control of haematopoietic stem cell proliferation by humoral factors.. Progress in Clinical and Biological Research, 59 B, 269-276.
- Changes in the growth fraction of haempoietic stem cells following treatment with normal rat bone marrow extract. Cell and Tissue Kinetics, 13(2), 211-212.
- Management of Mild‐to‐Moderate Atopic Dermatitis With Topical Treatments by Dermatologists: A Questionnaire‐Based Study. JEADV Clinical Practice.
- Real-Time In Vivo Human Skin Testing Using a Handheld Fourier Transform Infrared Spectrometer with a Three-Bounce Two-Pass Attenuated Total Reflection Interface. Applied Spectroscopy.
- Low Infection Rates With Long‐Term Dupilumab Treatment in Patients Aged 6 Months to 5 Years: An Open‐Label Extension Study. Pediatric Dermatology.
- Novel biophysical skin biomarkers discriminate topical anti‐inflammatory treatments based on their potential for local adverse effects. JEADV Clinical Practice.
- Practical Management of the JAK1 Inhibitor Abrocitinib for Atopic Dermatitis in Clinical Practice: Special Safety Considerations. Dermatology and Therapy.
- Emollient application from birth to prevent eczema in high-risk children: the BEEP RCT. Health Technology Assessment, 1-116.
- Integrated Safety Analysis of Abrocitinib in 635 Adolescent Patients With Moderate-To-Severe Atopic Dermatitis With Over 1000 Patient-Years of Exposure. SKIN The Journal of Cutaneous Medicine, 8(2), s379-s379.
- Progressive and Sustained Disease Control in Patients with Atopic Dermatitis (AD) Aged 12–17 Years Treated with Tralokinumab for 52 Weeks. SKIN The Journal of Cutaneous Medicine, 8(2), s377-s377.
- Clinically Meaningful Responses to Dupilumab Among Children Aged 6 Months to 5 Years with Moderate-to-severe Atopic Dermatitis who did Not Achieve Clear or Almost Clear Skin According to the Investigator’s Global Assessment: A Post Hoc Analysis of a Phase 3 Trial. Acta Dermato-Venereologica, 104, adv13467-adv13467.
- Dupilumab Treatment in Pediatric Patients Aged 6–11 Years with Severe Atopic Dermatitis Whose Disease Is Not Adequately Controlled: A Review. Drug Design, Development and Therapy, Volume 18, 277-289.
- Infections in Children Aged 6 Months to 5 Years Treated with Dupilumab in a Placebo-Controlled Clinical Trial of Moderate-to-Severe Atopic Dermatitis. Pediatric Drugs.
- Long-Term Efficacy of Abrocitinib in Adolescents and Adults With Moderate-to-Severe Atopic Dermatitis: A Post Hoc Analysis of JADE EXTEND. SKIN The Journal of Cutaneous Medicine, 8(1), s329-s329.
- Laboratory Parameters in Adolescent Patients Aged 12–17 with Moderate-to-Severe Atopic Dermatitis Treated with Tralokinumab Up to Week 52: Results from the Phase 3 ECZTRA 6 Trial. SKIN The Journal of Cutaneous Medicine, 8(1), s323-s323.
- Maintenance of an Acidic Skin Surface with a Novel Zinc Lactobionate Emollient Preparation Improves Skin Barrier Function in Patients with Atopic Dermatitis. Dermatology and Therapy.
- Characterisation of skin barrier defects in atopic dermatitis patients using Infrared Spectroscopy. Clinical and Experimental Dermatology.
- Safety of tralokinumab in pediatric patients aged 12-17 years with moderate to severe atopic dermatitis: results from the phase 3 ECZTRA 6 trial. SKIN The Journal of Cutaneous Medicine, 7(2), s140-s140.
- The impact of tralokinumab on quality of life and school in patients aged 12-17 with atopic dermatitis: results from the phase 3 ECZTRA 6 trial. SKIN The Journal of Cutaneous Medicine, 7(2), s139-s139.
- The impact of tralokinumab on quality of life and school in patients aged 12–17 with atopic dermatitis: results from the phase 3 ECZTRA 6 trial. SKIN The Journal of Cutaneous Medicine, 6(6), s77-s77.
- Early Changes in Patient-Relevant Endpoints in Three Tralokinumab Pivotal Phase 3 Trials (ECZTRA 1−3) in Adult Patients with Moderate-to-Severe Atopic Dermatitis. SKIN The Journal of Cutaneous Medicine, 4(6), s98-s98.
- Dupilumab Provides Acceptable Long-Term Safety and Efficacy in Children Aged ≥ 6 to < 12 Years with Uncontrolled, Severe Atopic Dermatitis. SKIN The Journal of Cutaneous Medicine, 4(6), s104-s104.
- Dupilumab improves patient-reported symptoms of atopic dermatitis, symptoms of anxiety and depression, and health-related quality of life in moderate-to-severe atopic dermatitis: analysis of pooled data from the randomized trials SOLO 1 and SOLO 2. Journal of Dermatological Treatment. View this article in WRRO
- Topical oils for the prevention or treatment of dry skin in term infants. Cochrane Database of Systematic Reviews.
Book chapters
- pH in Atopic Dermatitis, Current Problems in Dermatology (pp. 95-107). S. Karger AG
- Neonatal Skin Care and Toxicology In Eichenfield LF, Frieden IJ, Zaenglein A & Mathes E (Ed.), Neonatal and Infant Dermatology (pp. 46-56). Saunders
- Current and Future Trends: Skin Diseases and Treatment In Benson HAE & Watkinson AC (Ed.), Topical and Transdermal Drug Delivery Wiley
- The Skin Barrier in Atopic Dermatitis. In Irvine A, Hoeger P & Yan A (Ed.), Textbook of Pediatric Dermatology, UK: Blackwell Publishing Ltd..
- Skin Barrier Dysfunction in Atopic Dermatitis, Basic and Clinical Dermatology (pp. 211-240). Informa Healthcare
- Epidermal Barrier Dysfunction in Atopic Dermatitis In Rawlings L (Ed.), Skin Moisturization USA: Informa Healthcare USA Inc..
Conference proceedings
- Clinical remission and therapy-free remission in pediatric patients with moderate-to-severe atopic dermatitis treated with dupilumab: open-label extension study preliminary data. JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT, Vol. 23
- Progressive and sustained Disease Control in Patients with atopic Dermatitis (AD) aged 12 to 17 Years treated with Tralokinumab for 52 Weeks. ALLERGOLOGIE, Vol. 47(9)
- Langzeitwirksamkeit von Tralokinumab bei Jugendlichen mit mittelschwerer bis schwerer Atopischer Dermatitis. ALLERGOLOGIE, Vol. 47(9)
- Dupilumab Efficacy and Safety up to 2 Years in Children Aged 6 Months to 5 Years With Moderate-to-Severe Atopic Dermatitis. CRITICAL PUBLIC HEALTH, Vol. 34(1) (pp 14-15)
- Long-term dupilumab treatment is not associated with an increased overall risk of infections in patients aged 6 months to 5 years with moderate-to- severe atopic dermatitis in an open-label extension study. PEDIATRIC ALLERGY AND IMMUNOLOGY, Vol. 35
- Children with atopic dermatitis respond more rapidly to dupilumab treatment in comparison to adolescents and adults. JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol. 144(8) (pp S48-S48)
- 55 Dupilumab treatment normalizes skin barrier function and improves patient-reported outcomes in patients aged 6 to 11 years with moderate-to-severe atopic dermatitis. Journal of Investigative Dermatology, Vol. 143(11) (pp S342-S342)
- 410 Dupilumab treatment reduces total IgE levels in patients 6 months and older with moderate-to-severe atopic dermatitis. British Journal of Dermatology, Vol. 188(Supplement_3)
- 383 Integrated safety analysis of abrocitinib in 635 adolescent patients with moderate-to-severe atopic dermatitis with over 1000 patient-years of exposure. British Journal of Dermatology, Vol. 188(Supplement_3)
- 437 Treatment-emergent adverse events in patients aged 6 months to 5 years with moderate-to-severe atopic dermatitis treated with dupilumab in an open-label extension clinical trial. British Journal of Dermatology, Vol. 188(Supplement_3)
- 411 Long term laboratory safety of dupilumab in patients aged 6 months to 5 years with moderate-to-severe atopic dermatitis. British Journal of Dermatology, Vol. 188(Supplement_3)
- 337 Dupilumab treatment is not associated with an increased overall risk of infections in patients aged 6 months to 5 years with moderate-to-severe atopic dermatitis. British Journal of Dermatology, Vol. 188(Supplement_2)
- Dupilumab Treatment is Not AssociatedWith an Increased Overall Risk of Infections in Patients Aged 6 Months to 5 yearsWithModerate-to-Severe Atopic Dermatitis. JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT, Vol. 21 (pp 100-101)
- Treatment-Emergent Adverse Events in Patients Aged 6 Months to 5 Years With Moderate-to- Severe Atopic Dermatitis Treated With Dupilumab in an Open-Label Extension Clinical Trial. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, Vol. 89(3) (pp AB100-AB100)
- SAFETY OF TRALOKINUMAB IN PAEDIATRIC PATIENTS AGED 12-17 WITH MODERATE-TO-SEVERE AROPIC DERMATITIS: RESULTS FROM THE PHASE 3 ECZTRA 6 TRIAL. JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT, Vol. 21 (pp 58-58)
- Safety of Amlitelimab in a Phase 2a Clinical Trial of Patients With Moderate-to-Severe Atopic Dermatitis. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, Vol. 89(3) (pp AB221-AB221)
- PROGRESSIVE AND SUSTAINED DISEASE CONTROL IN PATIENTS WITH ATOPIC DERMATITIS (AD) AGED 12-17 YEARS TREATED WITH TRALOKINUMAB FOR 52 WEEKS. ACTA DERMATO-VENEREOLOGICA, Vol. 103 (pp 30-30)
- Long-term safety and efficacy of tralokinumab in adolescents with moderate-to-severe atopic dermatitis: an interim analysis of ECZTEND. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, Vol. 89(3) (pp AB190-AB190)
- LONG-TERM EFFICACY OF TRALOKINUMAB IN ADOLESCENTS WITH MODERATE-TO-SEVERE ATOPIC DERMATITIS. ACTA DERMATO-VENEREOLOGICA, Vol. 103 (pp 54-54)
- LONG-TERM DUPILUMAB TREATMENT IS NOT ASSOCIATED WITH AN INCREASED OVERALL RISK OF INFECTIONS IN PATIENTS AGED 6 MONTHS TO 5 YEARS WITH MODERATE-TO-SEVERE ATOPIC DERMATITIS IN AN OPENLABEL EXTENSION STUDY. ACTA DERMATO-VENEREOLOGICA, Vol. 103 (pp 54-54)
- Long Term Hematologic Laboratory Safety of Dupilumab in Patients Aged 6 Months to 5 Years With Moderate-to-Severe Atopic Dermatitis. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, Vol. 89(3) (pp AB62-AB62)
- Integrated Analysis of Abrocitinib for the Treatment of Adolescents with Moderate-to-Severe Atopic Dermatitis From the Phase 3 Clinical Trial Program. JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT, Vol. 21 (pp 77-77)
- EFFICACY AND SAFETY OF DUPILUMAB TREATMENT UP TO 1 YEAR IN INFANTS AND PRESCHOOL CHILDREN WITH MODERATE-TO-SEVERE ATOPIC DERMATITIS. ACTA DERMATO-VENEREOLOGICA, Vol. 103 (pp 53-53)
- Dupilumab treatment normalizes skin barrier function and improves patient-reported outcomes in patients aged 6 to 11 years with moderate-to-severe atopic dermatitis. JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol. 143(11) (pp S342-S342)
- Dupilumab Treatment Improves Sleep Quality in Children Aged 6 Months to 5 Years with Moderate-to-Severe Atopic Dermatitis and Their Caregivers. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, Vol. 89(3) (pp AB40-AB40)
- Sequence of improvement in atopic dermatitis signs and symptoms in patients aged 6 months to 17 years treated with dupilumab. ALLERGY, Vol. 78 (pp 196-196)
- Dupilumab treatment normalizes skin barrier function and symptoms in children aged 6-11 years with moderate-to-severe atopic dermatitis. ALLERGY, Vol. 78 (pp 194-194)
- Allergy profile for patients receiving dupilumab for severe atopic dermatitis. ALLERGY, Vol. 78
- Sustained long-term dupilumab efficacy in adult patients with moderate-to-severe atopic dermatitis transitioning from weekly dosing to every other week: Results from an open-label extension trial. CLINICAL AND EXPERIMENTAL ALLERGY, Vol. 52(8) (pp 1014-1014)
- Dupilumab treatment is associated with reductions in serum immunoglobulin E and thymus and activation-regulated chemokine levels in children aged 6 to 11 years with severe atopic dermatitis. CLINICAL AND EXPERIMENTAL ALLERGY, Vol. 52(8) (pp 1059-1059)
- Long-term efficacy of abrocitinib after initial successful treatment in patients with atopic dermatitis. BRITISH JOURNAL OF DERMATOLOGY, Vol. 187 (pp 72-72)
- A randomized controlled trial assessing the effectiveness and safety of ciclosporin vs. methotrexate in the treatment of severe atopic eczema in children and young people: the TREatment of severe Atopic eczema Trial (TREAT). BRITISH JOURNAL OF DERMATOLOGY, Vol. 187 (pp 13-14)
- Efficacy and safety of dupilumab in children aged ≥ 6 months to < 6 years with moderate-to-severe atopic dermatitis. BRITISH JOURNAL OF DERMATOLOGY, Vol. 186(4) (pp E173-E173)
- Efficacy and safety of dupilumab in children aged 6-11 years with inadequately controlled severe atopic dermatitis: results from an open-label extension trial up to 1 year. BRITISH JOURNAL OF DERMATOLOGY, Vol. 186(4) (pp E159-E160)
- Efficacy and safety of tralokinumab in adolescents with moderate-to-severe atopic dermatitis: results of the phase III ECZTRA 6 trial. BRITISH JOURNAL OF DERMATOLOGY, Vol. 187(3) (pp E90-E91)
- Clinically meaningful responses achieved with tralokinumab in adults with moderate-to-severe atopic dermatitis who did not meet IGA 0/1 at initial 16-week treatment. JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol. 142(8) (pp B17-B17)
- Dupilumab treatment improved sleep quality in moderate-to-severe atopic dermatitis in children aged 6 months-5 years and their caregivers. BRITISH JOURNAL OF DERMATOLOGY, Vol. 187(3) (pp E112-E113)
- A phase IIa study of amlitelimab, a novel nondepleting anti-OX40Ligand mAb in patients with moderate to severe atopic dermatitis. BRITISH JOURNAL OF DERMATOLOGY, Vol. 187(3) (pp E96-E96)
- Dupilumab treatment improves health-related quality of life in children aged 6 months-5 years with moderate-to-severe atopic dermatitis. BRITISH JOURNAL OF DERMATOLOGY, Vol. 187(3) (pp E104-E105)
- Efficacy and safety of dupilumab in children aged ≥ 6 months to < 6 years with moderate-to-severe atopic dermatitis. BRITISH JOURNAL OF DERMATOLOGY, Vol. 187 (pp 12-12)
- Dupilumab provides long-term efficacy over 2.5 years in adults with moderate-to-severe atopic dermatitis. BRITISH JOURNAL OF DERMATOLOGY, Vol. 187 (pp 69-69)
- Dupilumab provides long-term improvement in pruritus in children with severe atopic dermatitis and adolescents and adults with moderate-to-severe atopic dermatitis. BRITISH JOURNAL OF DERMATOLOGY, Vol. 187 (pp 79-79)
- Efficacy and safety of tralokinumab in adolescents with moderate-to-severe atopic dermatitis: results of the phase III ECZTRA 6 trial. BRITISH JOURNAL OF DERMATOLOGY, Vol. 186(4) (pp E145-E146)
- EFFECTS OF EMOLLIENT CREAMS ON THE SKIN BARRIER OF PATIENTS WITH ATOPIC DERMATITIS. ACTA DERMATO-VENEREOLOGICA, Vol. 102 (pp 35-36)
- 161 52-Week Laboratory Safety Findings From an Open-Label Extension Study of Dupilumab in Adolescent Patients With Atopic Dermatitis (LIBERTY AD PED-OLE). Abstracts (pp A68.2-A69)
- Dupilumab is effective in children aged 6-11 years with severe atopic Dermatitis (AD) regardless of baseline serum total immunoglobulin E levels. CLINICAL AND EXPERIMENTAL ALLERGY, Vol. 51(12) (pp 1659-1659)
- Dupilumab treatment leads to mild transient increases in eosinophil levels without clinical relevance in children aged 6-11 years with severe atopic dermatitis. CLINICAL AND EXPERIMENTAL ALLERGY, Vol. 51(12) (pp 1687-1688)
- Fifty-two-week laboratory safety findings from an open-label extension study of dupilumab in adolescent patients with atopic dermatitis (LIBERTY AD PED-OLE). BRITISH JOURNAL OF DERMATOLOGY, Vol. 185(3) (pp E121-E121)
- Long-term efficacy and safety data for dupilumab in a phase III open-label extension trial (LIBERTY AD PED-OLE) in patients aged ≥ 6 to < 12 years with uncontrolled moderate-to-severe atopic dermatitis. BRITISH JOURNAL OF DERMATOLOGY, Vol. 185(3) (pp E115-E116)
- 52-week laboratory safety findings from an open-label extension (OLE) study of dupilumab in adolescent patients with atopic dermatitis (LIBERTY AD PED-OLE). JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, Vol. 85(3) (pp AB120-AB120)
- Long-term efficacy and safety data for dupilumab in a phase 3, open-label extension trial (LIBERTY AD PED-OLE) in patients aged ≥6 to <12 years with uncontrolled, moderate-to-severe atopic dermatitis (AD). JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, Vol. 85(3) (pp AB120-AB120)
- Dupilumab improves Eczema Area and Severity Index regional scores across all anatomical regions in children aged 6-11 years with severe atopic dermatitis (AD). JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, Vol. 85(3) (pp AB136-AB136)
- Dupilumab provides clinically meaningful improvement in atopic dermatitis (AD) signs and symptoms and quality of life (QoL) in children with severe AD: Results from the LIBERTY AD PEDS phase 3 clinical trial. JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol. 141(5) (pp S84-S84)
- LABORATORY SAFETY OF DUPILUMAB IN PEDIATRIC PATIENTS AGED ≥6-<12 YEARS WITH SEVERE ATOPIC DERMATITIS: RESULTS FROM A PHASE 3 TRIAL (LIBERTY AD PEDS). ACTA DERMATO-VENEREOLOGICA, Vol. 101 (pp 59-59)
- LONG-TERM EFFICACY AND SAFETY OF DUPILUMAB IN A PHASE 3 OPEN-LABEL EXTENSION TRIAL (LIBERTY AD PED-OLE) IN PATIENTS AGED ≥ 6 TO<12 YEARS WITH MODERATE-TO-SEVERE ATOPIC DERMATITIS. ACTA DERMATO-VENEREOLOGICA, Vol. 101 (pp 60-60)
- Long-term efficacy and safety data for dupilumab in a phase 3, Open-Label Extension Trial (LIBERTY AD PED-OLE) in patients aged ≥6 to <12 years with moderate-to-severe atopic dermatitis (AD). JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT, Vol. 19 (pp 14-14)
- Efficacy and safety of crisaborole in patients with mild-to-moderate atopic dermatitis with and without comorbid allergies or asthma. BRITISH JOURNAL OF DERMATOLOGY, Vol. 185(3) (pp E110-E110)
- Impact of abrocitinib on itch, sleep, skin pain and psychological stress in patients with moderate-to-severe atopic dermatitis: pooled analysis from JADE monotherapy trials. BRITISH JOURNAL OF DERMATOLOGY, Vol. 185(3) (pp E72-E73)
- Dupilumab provides clinically meaningful improvement in atopic dermatitis (AD) signs, symptoms, and quality of life in children with severe AD: Results from the LIBERTY AD PEDS phase 3 clinical trial. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, Vol. 85(3) (pp AB141-AB141)
- Efficacy and safety of crisaborole in patients with mild-to-moderate atopic dermatitis with and without comorbid allergies or asthma. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, Vol. 85(3) (pp AB97-AB97)
- The targeted Action on Interleukin-13 with Tralokinumab improved the Sleep in two randomized, double-blind, placebo-controlled Phase III Studies in Patients with atopic Dermatitis. JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT, Vol. 19 (pp 56-56)
- Specifically targeting interleukin-13 with tralokinumab improved sleep in two phase III, randomized, double-blind, placebo-controlled trials in patients with atopic dermatitis. BRITISH JOURNAL OF DERMATOLOGY, Vol. 184(3) (pp E64-E65)
- Early changes in patient-relevant endpoints in three tralokinumab pivotal phase III trials (ECZTRA 1-3) in adult patients with moderate-to-severe atopic dermatitis. BRITISH JOURNAL OF DERMATOLOGY, Vol. 184(3) (pp E64-E64)
- LOWERING SKIN SURFACE PH WITH A TOPICAL ZINC LACTOBIONATE PREPARATION CONTAINING PHYSIOLOGIC LIPIDS IMPROVES SKIN BARRIER STRUCTURE AND FUNCTION IN ADULTS WITH ATOPIC DERMATITIS. ACTA DERMATO-VENEREOLOGICA, Vol. 101 (pp 51-51)
- Laboratory safety of dupilumab in paediatric patients aged ≥ 6 to < 12 years with severe atopic dermatitis: results from a phase III trial (LIBERTY AD PEDS). BRITISH JOURNAL OF DERMATOLOGY, Vol. 185(3) (pp E122-E123)
- A RANDOMISED CONTROLLED TRIAL OF DAILY EMOLLIENT DURING INFANCY FOR PREVENTING ECZEMA - RESULTS OF THE BEEP TRIAL. ACTA DERMATO-VENEREOLOGICA, Vol. 101 (pp 7-8)
- An investigation of the skin barrier restoring effects of a cream containing ceramides in a multivesicular emulsion in people with dry, eczema-prone, skin: The RESTORE study phase 2. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, Vol. 83(6) (pp AB71-AB71)
- Dupilumab improves signs and symptoms in adult and adolescent patients with erythrodermic atopic dermatitis: A pooled subgroup analysis. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, Vol. 83(6) (pp AB39-AB39)
- The use of systemic immunomodulatory agents in the treatment of children and adolescents with atopic eczema: lessons from the UK-Irish Atopic Eczema Systemic Therapy (A-STAR) Register. BRITISH JOURNAL OF DERMATOLOGY, Vol. 183 (pp 147-148)
- Dupilumab monotherapy improves signs, symptoms and quality of life in adult and adolescent patients with erythrodermic atopic dermatitis. JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol. 140(7) (pp S60-S60)
- Efficacy and safety of abrocitinib in patients with moderate-to-severe atopic dermatitis: results from the phase III, JADE MONO-1 study. BRITISH JOURNAL OF DERMATOLOGY, Vol. 183(4) (pp E105-E106)
- A real-world observational study to describe National Health Service resource use for the management of moderate-to-severe atopic dermatitis in secondary care for children and adolescents aged 6-17 years. BRITISH JOURNAL OF DERMATOLOGY, Vol. 183 (pp 147-147)
- 605 Efficacy and safety of dupilumab in adolescent patients with moderate-to-severe atopic dermatitis. Journal of Investigative Dermatology, Vol. 139(5) (pp S104-S104). Hilton Chicago, Chicago, Illinois, 8 May 2019 - 8 May 2019. View this article in WRRO
- Efficacy and safety of dupilumab in adolescent patients with moderate-to-severe atopic dermatitis. JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol. 139(5) (pp S104-S104)
- Clinically meaningful responses in moderate-to-severe atopic dermatitis patients treated with Dupilumab. JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT, Vol. 17 (pp 116-116)
- Quantification of natural moisturizing factors at the skin surface using a portable infrared spectrometer device: a pilot, calibration model. British Journal of Dermatology, Vol. 179(1) (pp E35-E36). Utrecht, Netherlands, 11 April 2018 - 11 April 2018. View this article in WRRO
- Characterizing the microcirculation of atopic dermatitis using angiographic optical coherence tomography. Proceedings of SPIE, Vol. 10037. San Francisco, California, 28 January 2017 - 28 January 2017. View this article in WRRO
- An open-label phase IIa trial assessing the pharmacokinetics, safety and efficacy of dupilumab in a paediatric population with moderate-to-severe atopic dermatitis. BRITISH JOURNAL OF DERMATOLOGY, Vol. 177 (pp 155-155)
- An open-label phase IIa trial assessing the pharmacokinetics, safety and efficacy of dupilumab in a paediatric population with moderate-to-severe atopic dermatitis. BRITISH JOURNAL OF DERMATOLOGY, Vol. 177 (pp 67-68)
- Dupilumab in moderate-to-severe atopic dermatitis: results from two randomized phase 3 trials (SOLO 1 & 2). JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT, Vol. 15 (pp 79-79)
- DUPILUMAB IMPROVES PATIENT-REPORTED OUTCOMES IN ATOPIC DERMATITIS PATIENTS INADEQUATELY CONTROLLED, INTOLERANT, OR INADVISABLE FOR CYCLOSPORINE-A. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, Vol. 119(5) (pp S94-S95)
- Characterisation of the skin barrier defect in atopic dermatitis using in vivo ATR-FTIR spectroscopy. JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol. 136(9) (pp S182-S182)
- A pilot, assessor-blinded, randomized controlled trial of topical oils for neonatal skin. BRITISH JOURNAL OF DERMATOLOGY, Vol. 173 (pp 153-153)
- Feasibility study of Barrier Enhancement For Eczema Prevention (BEEP). BRITISH JOURNAL OF DERMATOLOGY, Vol. 170(6) (pp E8-E9)
- The effect of a complex emollient cream containing 5% urea, ceramide 3 and lactic acid, compared with a simple emollient, on the skin barrier in older people with dry skin. BRITISH JOURNAL OF DERMATOLOGY, Vol. 171 (pp 57-58)
- Noninvasive assessment of the lipid structure and water holding properties of the stratum corneum in vivo by ATR-FTIR using a fibre optic probe in patients with atopic dermatitis and healthy controls. BRITISH JOURNAL OF DERMATOLOGY, Vol. 170(6) (pp E29-E29)
- A protocol for a randomized controlled trial to determine whether application of emollient from birth can prevent eczema in high-risk children (BEEP Trial). BRITISH JOURNAL OF DERMATOLOGY, Vol. 170(6) (pp E32-E32)
- A difficult case of atopic eczema: useful learning points. BRITISH JOURNAL OF DERMATOLOGY, Vol. 169 (pp 120-120)
- Chymotrypsin-like protease activity in the stratum corneum is increased in atopic dermatitis and upon washing with soap. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, Vol. 68(4) (pp AB172-AB172)
- Vitamin D supplementation improves atopic dermatitis and atopic dermatitis complicated by eczema herpeticum. BRITISH JOURNAL OF DERMATOLOGY, Vol. 167 (pp 127-127)
- Skin barrier breakdown in atopic dermatitis: the effect of topical products. INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 34(4) (pp 363-364)
- A randomized comparison of aqueous cream and Oilatum (R) Junior bath additive on skin barrier function in atopic dermatitis. BRITISH JOURNAL OF DERMATOLOGY, Vol. 165 (pp 115-115)
- A randomized comparison of aqueous cream and Oilatum (R) Junior bath additive on skin barrier function in atopic dermatitis. BRITISH JOURNAL OF DERMATOLOGY, Vol. 165 (pp 44-45)
- Patch testing is a useful investigation in children with eczema. BRITISH JOURNAL OF DERMATOLOGY, Vol. 161 (pp 125-125)
- Breakdown of the skin barrier induced by aqueous cream: implications for the management of atopic eczema. BRITISH JOURNAL OF DERMATOLOGY, Vol. 161 (pp 115-116)
- Skin protease inhibitors: a new treatment for atopic dermatitis. BRITISH JOURNAL OF DERMATOLOGY, Vol. 161 (pp 30-31)
- Skin protease inhibitors: A new treatment for atopic dermatitis. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, Vol. 60(3) (pp AB67-AB67)
- Contamination of emollient creams and ointments with Staphylococcus aureus in children with atopic eczema. BRITISH JOURNAL OF DERMATOLOGY, Vol. 159 (pp 114-114)
- Vitamin A metabolic pathway inhibition: a new therapeutic approach to treating psoriasis. BRITISH JOURNAL OF DERMATOLOGY, Vol. 159 (pp 118-118)
- Differences in the effect of topical corticosteroids and calcineurin inhibitors on the skin barrier - Implications for therapy. JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol. 127 (pp S45-S45)
- Severe alopecia areata is associated with a functional polymorphism in the PTPN22 gene. IMMUNOLOGY, Vol. 120 (pp 70-70)
- The effects of topical corticosteroids and pimecrolimus skin barrier function, gene expression, and topical drug penetration in atopic eczema and unaffected controls. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, Vol. 56(2) (pp AB69-AB69)
- Reduced and abnormal proteolysis of corneodesmosomal proteins in psoriatic skin. JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol. 126 (pp 116-116)
- A study on the effect of genetic variants of the autoimmune regulator (AIRE) promoter, on AIRE activity and downstream Aire-regulated genes. BRITISH JOURNAL OF DERMATOLOGY, Vol. 155(1) (pp 250-250)
- A synonymous single nucleotide polymorphism in human cystatin A, a candidate gene in the PSORS5 locus, confers susceptibility to psoriasis. BRITISH JOURNAL OF DERMATOLOGY, Vol. 155(1) (pp 235-235)
- Interaction of topical corticosteroids and pimecrolimus with the skin barrier: Implications for efficacy and safety of treatment for atopic dermatitis. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, Vol. 54(3) (pp AB3-AB3)
- Skin barrier damage: Cause or consequence of atopic dermatitis?. JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol. 125(3) (pp 605-605)
- Treatment of atopic dermatitis from a skin barrier perspective. JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol. 125(3) (pp 611-611)
- Skin barrier damage: Cause or consequence of atopic dermatitis?. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, Vol. 52(3) (pp P9-P9)
- An audit of adverse drug reactions to aqueous cream in children with atopic eczema. BRITISH JOURNAL OF DERMATOLOGY, Vol. 151 (pp 57-58)
- Abnormal proteolysis of corneodesmosin in psoriatic skin. JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol. 121(6) (pp 1568-1568)
- Role of variants within genes regulating the skin barrier in the pathogenesis of atopic eczema. BRITISH JOURNAL OF DERMATOLOGY, Vol. 149 (pp 4-4)
- Genetic analysis of the autoimmune regulator (aire) gene: potential role of aire in susceptibility to alopecia universalis. BRITISH JOURNAL OF DERMATOLOGY, Vol. 148(4) (pp 849-850)
- Alopecia areata: age at onset, atopy & disease associations. BRITISH JOURNAL OF DERMATOLOGY, Vol. 148(4) (pp 866-867)
- Introduction. Journal of Investigative Dermatology Symposium Proceedings, Vol. 4(3) (pp 199-199)
- The role of in atopic eczema: treatment strategies. Journal of the European Academy of Dermatology and Venereology, Vol. 7 (pp S31-S37)
- Efficacy and safety of tralokinumab in adolescents with moderate-to- severe atopic dermatitis: results of the phase 3 ECZTRA 6 trial. SKIN The Journal of Cutaneous Medicine, Vol. 6(2) (pp s29-s29)
Reports
Posters
- 41343 Safety of Amlitelimab in a Phase 2a Clinical Trial of Patients With Moderate-to-Severe Atopic Dermatitis.
- 41817 Dupilumab Treatment Improves Sleep Quality in Children Aged 6 Months to 5 Years with Moderate-to-Severe Atopic Dermatitis and Their Caregivers.
- 43997 Long-term safety and efficacy of tralokinumab in adolescents with moderate-to-severe atopic dermatitis: an interim analysis of ECZTEND.
- 42924 Treatment-Emergent Adverse Events in Patients Aged 6 Months to 5 Years With Moderate-to- Severe Atopic Dermatitis Treated With Dupilumab in an Open-Label Extension Clinical Trial.
- 42008 Long Term Hematologic Laboratory Safety of Dupilumab in Patients Aged 6 Months to 5 Years With Moderate-to-Severe Atopic Dermatitis.
- P24 Emollient use and effects on cutaneous allergen reactions: a preliminary study.
- P40 Dupilumab treatment restores skin barrier function in lesional and nonlesional skin of patients with atopic dermatitis and improves patient-reported outcomes.
- P73 Laboratory safety from a 16-week phase III study of dupilumab in patients aged 6 months–5 years with moderate-to-severe atopic dermatitis.
- P81 Long-term efficacy of abrocitinib in adolescents and adults with moderate-to-severe atopic dermatitis: a post hoc analysis of JADE EXTEND.
- 392 Safety of amlitelimab in a Phase 2a clinical trial of patients with moderate-to-severe atopic dermatitis.
- 353 Amlitelimab reduces serum IL-13 in a phase 2a clinical trial in atopic dermatitis without impacting T-cell expansion in a T-cell recall assay.
- 345 Treatment with amlitelimab—a novel non-depleting, non-cytotoxic anti-OX40Ligand monoclonal antibody—reduces IL-22 serum levels in a phase 2a randomized, placebo-controlled trial in patients with moderate-to-severe atopic dermatitis.
- 34326 Real-world analysis of skin infections and antimicrobial use among patients with atopic dermatitis before and after initiation of dupilumab treatment.
- 34312 Treatment with amlitelimab (KY1005, SAR445229): A novel nondepleting anti-OX40Ligand (OX40L) mAb reduces IL-13 serum levels in a phase 2a randomized placebo-controlled trial in patients with moderate to severe atopic dermatitis.
- 33569 Optimization of common hand cleansers for protection from viral spread and occupational hand dermatoses.
- 34655 Integrated analysis of abrocitinib for the treatment of adolescents with moderate-to-severe atopic dermatitis from the phase 3 clinical trial program.
- 33781 Sustained and durable response up to 24 weeks after last dose observed in a phase 2a study (NCT03754309) of amlitelimab (KY1005, SAR445229) a novel nondepleting anti-OX40Ligand (OX40L) mAb in patients with moderate to severe atopic dermatitis (AD).
- LB946 Clinically meaningful responses achieved with tralokinumab in adults with moderate-to-severe atopic dermatitis who did not meet IGA 0/1 at initial 16-week treatment.
- 27394 Dupilumab provides clinically meaningful improvement in atopic dermatitis (AD) signs, symptoms, and quality of life in children with severe AD: Results from the LIBERTY AD PEDS phase 3 clinical trial.
- 27350 Dupilumab improves Eczema Area and Severity Index regional scores across all anatomical regions in children aged 6–11 years with severe atopic dermatitis (AD).
- 26880 Long-term efficacy and safety data for dupilumab in a phase 3, open-label extension trial (LIBERTY AD PED-OLE) in patients aged ≥6 to <12 years with uncontrolled, moderate-to-severe atopic dermatitis (AD).
- 26875 52-week laboratory safety findings from an open-label extension (OLE) study of dupilumab in adolescent patients with atopic dermatitis (LIBERTY AD PED-OLE).
- 16818 An investigation of the skin barrier restoring effects of a cream containing ceramides in a multivesicular emulsion in people with dry, eczema-prone, skin: The RESTORE study phase 2.
- 15413 Dupilumab improves signs and symptoms in adult and adolescent patients with erythrodermic atopic dermatitis: A pooled subgroup analysis.
- P302 EFFICACY OF CRISABOROLE IN PATIENTS WITH MILD-TO-MODERATE ATOPIC DERMATITIS WITH AND WITHOUT FOOD ALLERGIES.
- P500 EFFICACY OF CRISABOROLE IN PATIENTS WITH MILD-TO-MODERATE ATOPIC DERMATITIS WITH AND WITHOUT COMORBID ALLERGIC RHINITIS.
- Efficacy and Safety of Crisaborole in Patients With Mild-to-Moderate Atopic Dermatitis With and Without Food Allergies.
- Specifically Targeting Interleukin-13 with Tralokinumab Improved Sleep in Two Phase 3, Randomized, Double-Blind, Placebo-Controlled Trials in Patients with Atopic Dermatitis.
- Efficacy and Safety of Crisaborole in Patients With Mild-to-Moderate Atopic Dermatitis With and Without Comorbid Allergic Rhinitis.
- Dupilumab safety and efficacy up to 1 Year in children aged 6 months to 5 years with atopic dermatitis: results from a phase 3 open-label extension study. American Journal of Clinical Dermatology, 25(4), 655-668. View this article in WRRO
- Teaching interests
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My teaching interests within The University include medical undergraduate lecturing and in-clinic training plus postgraduate researcher training and mentoring. I also lecture to related courses at other universities, such as the MSc in Dermatology at Cardiff and at major international and national conferences in the field of dermatology. In addition I undertake a large number of atopic eczema related educational presentations at local, national and international level to a wide range of audiences including; pharmacists, general practitioners, hospital nurses, community nurses, midwives, paediatricians, practice nurses and patient support charities (e.g. National Eczema Society, Skin Care Campaign and Psoriasis Association).
Education of Children with Skin Diseases:
I have developed a special interest in `translating´ the complex pathophysiology of skin disease into cartoons and language that can be understood by a child of six. I presented these to the National Eczema Society and the Skin Care Campaign. I have written papers for these charities describing the content of the lectures, for example Cork et al 2000; 2002 "Skin Wars". I use the cartoons in my clinics to teach children and their parent about skin diseases. The medical students that sit-in during my clinics, suggested I incorporated the "Skin Wars" cartoons into their lectures because they made dermatology exciting. The "Skin Wars" cartoons have been disseminated to many other dermatology departments. I have assigned all commercial profits from use of the "Skin Wars" cartoons to the National Eczema Society. The "Skin Wars" teaching approach was cited as being an innovative approach to education by the judges in the Hospital Doctor Dermatology Team of the Year Awards, which our paediatric dermatology team won in 2001. This teaching method was also highlighted in the National Eczema Society Health Care Professionals Award 2004.
- Professional activities and memberships
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- Member of the National Institute of Clinical Excellence (NICE) clinical guideline development group for the treatment of Atopic Eczema in children.
- Advisor, Lecturer and developer of educational materials for the National Eczema Society, Skin Care Campaign, Psoriasis Association and Allergy UK.
- Wellcome Trust Translational Grants Reviewer & Expert Panel member.
- Grant Reviewer, British Skin Foundation, Psoriasis Association and Wellcome Trust.
- Fellow of the Royal College of Physicians, London and Edinburgh.
- Member of British Association of Dermatologists.
- Member of European Academy of Dermatology and Venereology.
- Member of British Society for Investigative Dermatology.
- Member of European Society for Dermatological Research.
- Member of British Society for Paediatric Dermatology.
- Member of Dowling Dermatology Society.
- Professional Member of the National Eczema Society.
- Member of The Council (board) of the Psoriasis Association.
- South Yorkshire Biotech Enterprise Network (SYBEN): York Pharma – Biotech company of the year, 2006.
- Yorkshire Forward Bioscience Yorkshire Annual Awards: Molecular Skin Care: Recognised for Outstanding Achievements in Bioscience. Awarded to the company who has made the greatest advances in Yorkshire in 2005.
- Leader of the team awarded ‘Health Care Professional Team of the Year’ by the National Eczema Society in 2004.
- Leader of the team awarded ‘Hospital Doctor Dermatology Team of the Year’ 2001.
- Enquiries
For Teaching & Academic Supervisory Enquiries, Post-Graduate and Undergraduate (i.e. PATs) please email:
Les Hunter & cc to Prof. Michael J. Cork
For Research Enquiries (including Pharmacological, Cosmetic & Academic) please email: Les Hunter & cc to Prof. Michael J. Cork
For Children’s Clinical NHS Enquiries please email: Elaine Cox & cc to Prof. Michael J. Cork
For Adult Clinical NHS Enquiries please email: Lucy Lowe & cc to Prof. Michael J. Cork