Dr Lisa Parker
BSc, MRes, PhD
Clinical Medicine, School of Medicine and Population Health
Lecturer in Inflammation Biology
+44 114 215 9544
Full contact details
Clinical Medicine, School of Medicine and Population Health
The Medical School
Beech Hill Road
Sheffield
S10 2RX
- Profile
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For enquiries please contact - SMPH-West-Operational@sheffield.ac.uk
I graduated from the University of Manchester in 1996 with a BSc (First Class Honours) in Neuroscience. I then completed an MRes in Neuroscience (University of Manchester, 1997) followed by my PhD entitled `Interleukin-1 and its receptors in the brain´ under the supervision of Professor Dame Nancy Rothwell (University of Manchester, 1997-2000).
I joined the University of Sheffield in 2001 to take up my first post-doctoral position, where I was keen to maintain and develop my interest into inflammatory mechanisms in disease, with a focus on the respiratory system. In 2010 I was appointed to a lectureship within the Inflammation Biology Research Group in the Department of Infection, Immunity & Cardiovascular Disease.
During my time at the University of Sheffield my interest in learning and teaching has also continued to develop. In 2014 I was awarded the Postgraduate Certificate in Learning and Teaching (PG CiLT), and also became a Fellow of The Higher Education Academy (FHEA). I am currently the Deputy Departmental Director of Learning and Teaching for the Department of Infection, Immunity & Cardiovascular Disease.
- Qualifications
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Academic:
- 2000 PhD. Division of Neuroscience. The University of Manchester. Professor Dame Nancy Rothwell & Dr Giamal Luheshi.
- 1997 MRes. Division of Neuroscience. The University of Manchester.
- 1996 BSc (Hons) First class. Neuroscience. The University of Manchester.
Professional:
- 2014 Postgraduate Certificate in Learning and Teaching (PGCert Learning and Teaching). The University of Sheffield.
- 2014 Fellow of the Higher Education Academy (FHEA).
- Research interests
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My current research aims to identify how respiratory viruses infect and trigger proinflammatory responses in airway epithelial cells and to determine how the responses that are generated may be modified. Pathogens are detected by Toll-Like receptors (TLRs), a family of receptors that regulate cell activation, however the mechanisms through which pathogens initiate airway exacerbations remain inadequately defined. A more complete understanding of the host innate immune responses and the complex signalling pathways that are triggered by viral pathogens is crucial, as viruses are a major trigger of acute exacerbations in asthma and chronic obstructive pulmonary disease (COPD).
My current goals are investigating key players in these pathways to ultimately enable the development of novel therapeutic targets and approaches to manage airway inflammation.
Current Projects
- 2021-2022 Sheffield Children’s NHS Foundation Trust “A potential new treatment for respiratory syncytial viral (RSV) infection, and bacterial co-infections, in children”. Dr Lisa Parker, Dr Kelechi Ugonna.
- 2018-2021 Rosetrees Trust PhD research grant “Reversing viral-induced cell stress to treat asthma”. Dr Lisa Parker, Prof Alison Condliffe.
- 2018-2021 PhD studentship FMDH Summer 2018 PGT to PGR Scholarship “Investigating the role of membrane microdomains in Respiratory Syncytial Viral infection and their potential as novel therapeutic targets”. Dr Lisa Parker, Prof I Sabroe.
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- Role of unfolded proteins in lung disease. Thorax. View this article in WRRO
- Pellino-1 regulates the responses of the airway to viral infection. Frontiers in Cellular and Infection Microbiology, 10. View this article in WRRO
- Airway epithelial cells generate pro-inflammatory Tenascin-C and small extracellular vesicles in response to TLR3 stimuli and rhinovirus infection. Frontiers in Immunology, 10. View this article in WRRO
- DUSP10 Negatively Regulates the Inflammatory Response to Rhinovirus Through IL-1β Signalling. Journal of Virology. View this article in WRRO
- Human rhinovirus-induced inflammatory responses are inhibited by phosphatidylserine containing liposomes. Mucosal Immunology, 9(5), 1303-1303. View this article in WRRO
- Phosphoinositide-3 kinase inhibition modulates responses to rhinovirus by mechanisms that are predominantly independent of autophagy.. PLoS One, 9(12). View this article in WRRO
- Rhinoviral infection and asthma: the detection and management of rhinoviruses by airway epithelial cells.. Clin Exp Allergy, 44(1), 20-28.
- Pellino-1 selectively regulates epithelial cell responses to rhinovirus.. J Virol, 86(12), 6595-6604.
- Role of interleukin-1 and MyD88-dependent signaling in rhinovirus infection.. J Virol, 85(15), 7912-7921. View this article in WRRO
- A phosphatidylserine species inhibits a range of TLR- but not IL-1beta-induced inflammatory responses by disruption of membrane microdomains.. J Immunol, 181(8), 5606-5617.
All publications
Journal articles
- Role of unfolded proteins in lung disease. Thorax. View this article in WRRO
- Pellino-1 regulates the responses of the airway to viral infection. Frontiers in Cellular and Infection Microbiology, 10. View this article in WRRO
- Airway epithelial cells generate pro-inflammatory Tenascin-C and small extracellular vesicles in response to TLR3 stimuli and rhinovirus infection. Frontiers in Immunology, 10. View this article in WRRO
- Emerging Regulatory Roles of Dual-Specificity Phosphatases in Inflammatory Airway Disease. International Journal of Molecular Sciences, 20(3). View this article in WRRO
- DUSP10 Negatively Regulates the Inflammatory Response to Rhinovirus Through IL-1β Signalling. Journal of Virology. View this article in WRRO
- Human rhinovirus-induced inflammatory responses are inhibited by phosphatidylserine containing liposomes. Mucosal Immunology, 10.
- Human rhinovirus-induced inflammatory responses are inhibited by phosphatidylserine containing liposomes. Mucosal Immunology, 9(5), 1303-1303. View this article in WRRO
- Phosphoinositide-3 kinase inhibition modulates responses to rhinovirus by mechanisms that are predominantly independent of autophagy.. PLoS One, 9(12). View this article in WRRO
- Rhinoviral infection and asthma: the detection and management of rhinoviruses by airway epithelial cells.. Clin Exp Allergy, 44(1), 20-28.
- The role of interleukin-1 and interleukin-18 in pro-inflammatory and anti-viral responses to rhinovirus in primary bronchial epithelial cells.. PLoS One, 8(5), e63365. View this article in WRRO
- Muckle-Wells syndrome without mutation in exon 3 of the NLRP3 gene, identified by evidence of excessive monocyte production of functional interleukin 1β and rapid response to anakinra. Clinical and Experimental Dermatology.
- Roles of neutrophils in the regulation of the extent of human inflammation through delivery of IL-1 and clearance of chemokines.. J Leukoc Biol, 93(1), 7-19. View this article in WRRO
- Diesel exhaust particle exposure in vitro alters monocyte differentiation and function.. PLoS One, 7(12), e51107. View this article in WRRO
- Pellino-1 selectively regulates epithelial cell responses to rhinovirus.. J Virol, 86(12), 6595-6604.
- The role of TLRs in neutrophil activation. CURR OPIN PHARMACOL, 11(4), 397-403. View this article in WRRO
- Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice.. J Clin Invest, 121(3), 1053-1063. View this article in WRRO
- Prolyl Hydroxylase Phd3 Is Essential For Hypoxic Regulation Of Neutrophilic Inflammation. C13. PATHOGENESIS OF ACUTE LUNG INJURY.
- Role of interleukin-1 and MyD88-dependent signaling in rhinovirus infection.. J Virol, 85(15), 7912-7921. View this article in WRRO
- Temporal interleukin-1beta secretion from primary human peripheral blood monocytes by P2X7-independent and P2X7-dependent mechanisms.. J Biol Chem, 285(30), 23147-23158.
- Diesel exhaust particles override natural injury-limiting pathways in the lung.. Am J Physiol Lung Cell Mol Physiol, 299(2), L263-L271.
- Diesel Exhaust Particles Alter Monocyte Differentiation In Vitro. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 181.
- The Role of Cell Networks in Response to Diesel Exhaust Particles. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 179.
- The generation of highly purified primary human neutrophils and assessment of apoptosis in response to Toll-like receptor ligands.. Methods Mol Biol, 517, 191-204.
- A phosphatidylserine species inhibits a range of TLR- but not IL-1beta-induced inflammatory responses by disruption of membrane microdomains.. J Immunol, 181(8), 5606-5617.
- Differential and cell-type specific regulation of responses to Toll-like receptor agonists by ISO-1.. Immunology, 125(1), 101-110.
- Pathological networking: a new approach to understanding COPD.. Postgrad Med J, 84(991), 259-264.
- The role of TLR activation in inflammation.. J Pathol, 214(2), 126-135.
- Practical and conceptual models of chronic obstructive pulmonary disease.. Proc Am Thorac Soc, 4(8), 606-610.
- Pathological networking: a new approach to understanding COPD.. Thorax, 62(8), 733-738.
- Targeting the networks that underpin contiguous immunity in asthma and chronic obstructive pulmonary disease.. Am J Respir Crit Care Med, 175(4), 306-311. View this article in WRRO
- Translational mini-review series on Toll-like receptors: networks regulated by Toll-like receptors mediate innate and adaptive immunity.. Clin Exp Immunol, 147(2), 199-207.
- Cooperative molecular and cellular networks regulate Toll-like receptor-dependent inflammatory responses.. FASEB J, 20(12), 2153-2155.
- Endotoxin tolerance induces selective alterations in neutrophil function.. J Leukoc Biol, 78(6), 1301-1305.
- The expression and roles of Toll-like receptors in the biology of the human neutrophil.. J Leukoc Biol, 77(6), 886-892.
- Toll-like receptor (TLR)2 and TLR4 agonists regulate CCR expression in human monocytic cells.. J Immunol, 172(8), 4977-4986.
- Expression of interleukin-1 receptors and their role in interleukin-1 actions in murine microglial cells.. J Neurochem, 83(4), 754-763.
- The Role of TLRs in Leukocyte Function. Clinical Science, 103(s47), 55P-55P.
- Toll-like receptors: their role in allergy and non-allergic inflammatory disease.. Clin Exp Allergy, 32(7), 984-989.
- IL-1 beta signalling in glial cells in wildtype and IL-1RI deficient mice.. Br J Pharmacol, 136(2), 312-320.
- Interleukin-1 influences ischemic brain damage in the mouse independently of the interleukin-1 type I receptor.. J Neurosci, 22(1), 38-43.
- IL-1beta induced changes in hypothalamic IL-1R1 and IL-1R2 mRNA expression in the rat.. Brain Res Mol Brain Res, 79(1-2), 156-158.
- Cortical cell death induced by IL-1 is mediated via actions in the hypothalamus of the rat.. Proc Natl Acad Sci U S A, 97(10), 5580-5585.
- Expression of the IL-1 type I receptor and accessory protein in mouse primary glial cell cultures. EUR J NEUROSCI, 12, 359-359.
- Interleukin-1 type-1 receptor expression in the rat hypothalamus. BRIT J PHARMACOL, 123, U106-U106.
- Phasic and tonic reflexes evoked in human antagonistic wrist muscles by tendon vibration.. Electroencephalogr Clin Neurophysiol, 109(1), 24-35.
- Autogenetic and reciprocal tonic reflex actions of muscle vibration-evoked afferent input studied in human wrist muscles.. J PHYSIOL-LONDON, 504P, P119-P119.
Chapters
- Pathogen Recognition Receptors and the Lung, Reference Module in Biomedical Sciences Elsevier
Conference proceedings papers
- S98 Pellino-1 regulates the responses of the airway to viral infection. The influence of influenza: from cells to humans
- Human rhinovirus infection of airway epithelial cells induces tenascin-C release mas. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Vol. 99(6) (pp A59-A59)
- P55 Exploring rhinovirus-induced er stress in bronchial airway epithelial cells. Cellular insights into lung injury repair
- The Role Of Pellino-1 In Modulating Signalling Pathways Controlling The Inflammatory Response To Viral Stimuli In Airway Epithelial Cells. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 193
- Phosphoinositide 3-kinase (PI3K) inhibition modulates responses to rhinovirus by mechanisms that are predominantly independent of autophagy. IMMUNOLOGY, Vol. 140 (pp 84-85)
- The role of Pellino1 in modulating signalling pathways controlling the inflammatory response to viruses in airway epithelial cells. IMMUNOLOGY, Vol. 140 (pp 82-82)
- Phosphatidylserine-containing liposomes: modulators of rhinovirus induced inflammatory responses. IMMUNOLOGY, Vol. 140 (pp 108-108)
- Elucidating The Mechanism By Which Monocytes Can Inhibit Hypoxic PA-SMC Proliferation. D33. ASTHMA PATHOGENESIS
- INVESTIGATING THE ROLE OF PELLIN01, AN E3 UBIQUITIN LIGASE, IN MODULATING SIGNALLING PATHWAYS CONTROLLING THE INFLAMMATORY RESPONSE. THORAX, Vol. 66 (pp A60-A61)
- CHRONIC DIESEL EXHAUST PARTICLE (DEP) EXPOSURE DIFFERENTIALLY ALTERS MONOCYTE DIFFERENTIATION AND FUNCTION IN HEALTHY CONTROLS COMPARED TO COPD. THORAX, Vol. 66 (pp A114-A114)
- The role of neutrophils as anti-inflammatory mediators of airway inflammation. CLINICAL AND EXPERIMENTAL ALLERGY, Vol. 41(12) (pp 1830-1830)
- DIESEL EXHAUST PARTICLES ALTER MONOCYTE DIFFERENTIATION IN VITRO BUT HAVE LITTLE IMPACT ON NEUTROPHIL FUNCTION. THORAX, Vol. 65 (pp A66-A67)
- THE ROLE OF MYD88 IN RHINOVIRUS 1B INFECTION. THORAX, Vol. 65 (pp A37-A38)
- DIESEL EXHAUST PARTICLES POTENTIATE INFLAMMATION AND RENDER IT RESISTANT TO IL-1 ANTAGONISM IN VITRO. THORAX, Vol. 64 (pp A54-A55)
- Inhibition of TLR-induced inflammatory responses by SAPS. JOURNAL OF LEUKOCYTE BIOLOGY (pp 51-51)
- Regulation of TLR induced human inflammatory responses by macrophage migration inhibitory factor. JOURNAL OF LEUKOCYTE BIOLOGY (pp 60-60)
- The role of Cell networks in the response to Diesel Exhaust Particles (DEP).. JOURNAL OF LEUKOCYTE BIOLOGY (pp 25-25)
- The induction of antiviral responses in human airway smooth muscle and epithelial cells. THORAX, Vol. 61 (pp II9-II9)
- Toll-like receptor (TLR) 4 activation induces tolerance in the human neutrophil. FASEB JOURNAL, Vol. 19(4) (pp A912-A912)
- Endotoxin tolerance in the human neutrophil. JOURNAL OF LEUKOCYTE BIOLOGY (pp 43-44)
- Site-specific actions of interleukin-1 in neurodegeneration. PHARMACOLOGY OF CEREBRAL ISCHEMIA 2000 (pp 425-431)
- Research group
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PhD Students
- Joanne Mckenzie
- Kirsty Bradley
- Teaching interests
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I come from a background of scientific research where collaboration, critical thinking and discussion are key to the construction of new knowledge, and I believe these principles can also be applied to my teaching practice within the classroom environment. I am committed to the continual improvement of my own teaching practice, and teaching within my Department and Faculty, and ultimately providing students with the very best learning experiences.
I am Deputy Departmental Director of Learning & Teaching for the Department and I teach at all levels within the Faculty of MDH and for the School of Biosciences (see Teaching activities). I also provide pastoral support to students and am an active member of the Think Ahead mentoring scheme.
- Teaching activities
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Undergraduate:
- CDL21001 Research Skills in Biomedical Science (Course lead)
- CDL302 Pharmacology of Respiratory Disease (Module lead)
- ORT107 Anatomy & physiology
- MBChB Phase 2A Research attachment SSC
- MBChB Personal & Academic Tutoring
Postgraduate:
- MED6090 Project Literature Review (Module lead)
- MED60n3 Project Presentation (Module lead)
- MED6006 Modulating Immunity
- MED6060 Virulence Mechanisms of Viruses and Fungi
- CDL402: Vascular Disease: Models and Clinical Practice (Module lead)
- MSc and PhD Personal & Academic Tutoring
- Professional activities and memberships
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- Fellow of the Higher Education Academy (SFHEA).
- Research Meeting Working Group representative, Department of Infection, Immunity & Cardiovascular Disease (IICD).
- Early Career Group representative, Department of Infection, Immunity & Cardiovascular Disease (IICD).
- Think Ahead Career Development Mentor.
- Member of the Society for Leukocyte Biology
- Science and Engineering Ambassador (STEMNET programme).
- Member of Centre for Membrane Interactions and Dynamics (CMIAD).
- Member of the British Society for Immunology