Dr Karan Mehul Shah

PhD, MSc, B.Tech

Clinical Medicine, School of Medicine and Population Health

Research Associate

k.shah@sheffield.ac.uk
+44 114 215 9025

DU24, D Floor, The Medical School

Full contact details

Dr Karan Mehul Shah
Clinical Medicine, School of Medicine and Population Health
DU24, D Floor
The Medical School
Beech Hill Road
Sheffield
S10 2RX

Profile

For enquiries please contact - ClinMed-Operational@sheffield.ac.uk

I graduated with a B.Tech in Biotechnology at Amity University, Noida, India in 2008, and moved to Sheffield to pursue an MSc in Molecular Medicine (2008-2009). Subsequently, I completed a NIHR Biomedical Research Unit for Musculoskeletal Disease funded PhD (2009-2014) investigating the effects of metal ions and nanoparticles on bone cell physiology under the mentorship of Prof Mark Wilkinson and Prof Alison Gartland.

To build on the findings from my PhD, I secured post-doctoral funding (2014-2016) from Orthopaedic Research UK (Grant Ref: 517) to investigate the molecular mechanisms that regulate the detrimental effects of metal debris on bone cells.

Since September 2016, I have been a post-doctoral researcher with Prof. Alison Gartland on a Breast Cancer Now funded study focussed on understanding the role of lysyl oxidase and purinergic signalling in breast cancer metastasis to bone.

Research interests

Metastatic cancer is the cause of most cancer-related deaths, and my current research interest is to understand how primary tumour facilitates pre-metastatic niche formation in specific distant organs. To that end, I am exploring the role of extracellular vesicles (EV) in metastasis and organotropism. Specifically, I am interested in the mechanisms that regulate EV release from tumour cells, and the effects these EVs have on the cells of the distant metastatic site, especially bone.

Funding and Awards:

Early Career Researcher Prize for Excellence in Outreach/Public Engagement and Excellence in Supervision/Teaching by Faculty of Medicine, Dentistry & Health, University of Sheffield (2016).

Orthopaedic Research UK Post-doctoral Funding Co-applicant ‘Biological effects of tribocorrosion products on the bone microenvironment and prosthesis osseo-integration’ (£93,245.00).

William H. Harris Award for ‘outstanding work in orthopaedic research related to the hip’ awarded at the Orthopaedic Research Society Annual Meeting, New Orleans, USA (2014)

National Institute of Health Research Biomedical Research Fellowship (BRF-2011-013 and BRF-2011-020) for ‘The Effect of Metal Ions after Hip Resurfacing on Bone Cell Health’ (£71,187.00)

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Jiang W, Jin Y, Zhang S, Ding Y, Huo K, Yang J, Zhao L, Nian B, Zhong TP, Lu W , Zhang H et al (2022) PGE2 activates EP4 in subchondral bone osteoclasts to regulate osteoarthritis. Bone Research, 10(1). View this article in WRRO
Jin Y, Liu Q, Chen P, Zhao S, Jiang W, Wang F, Li P, Zhang Y, Lu W, Zhong TP , Ma X et al (2022) A novel prostaglandin E receptor 4 (EP4) small molecule antagonist induces articular cartilage regeneration. Cell Discovery, 8(1). View this article in WRRO
Tattersall L, Shah KM, Lath DL, Singh A, Down JM, De Marchi E, Williamson A, Di Virgilio F, Heymann D, Adinolfi E , Fraser WD et al (2021) The P2RX7B splice variant modulates osteosarcoma cell behaviour and metastatic properties. Journal of Bone Oncology, 31. View this article in WRRO
Shah KM, Dunning MJ, Gartland A & Wilkinson JM (2021) Distinct concentration-dependent molecular pathways regulate bone cell responses to cobalt and chromium exposure from joint replacement prostheses. International Journal of Molecular Sciences, 22(10). View this article in WRRO
Steinberg J, Southam L, Fontalis A, Clark MJ, Jayasuriya RL, Swift D, Shah KM, Brooks RA, McCaskie AW, Wilkinson JM & Zeggini E (2021) Linking chondrocyte and synovial transcriptional profile to clinical phenotype in osteoarthritis. Annals of the Rheumatic Diseases.
Steinberg J, Southam L, Roumeliotis TI, Clark MJ, Jayasuriya RL, Swift D, Shah KM, Butterfield NC, Brooks RA, McCaskie AW , Bassett JHD et al (2021) A molecular quantitative trait locus map for osteoarthritis. Nature Communications, 12. View this article in WRRO
Steinberg J, Shah KM, Gartland A, Zeggini E & Wilkinson JM (2017) Effects of chronic cobalt and chromium exposure after metal-on-metal hip resurfacing: An epigenome-wide association pilot study. Journal of Orthopaedic Research, 35(10), 2323-2328. View this article in WRRO
Shah KM, Orton P, Mani N, Wilkinson JM & Gartland A (2016) Osteocyte physiology and response to fluid shear stress are impaired following exposure to cobalt and chromium: Implications for bone health following joint replacement.. Journal of Orthopaedic Research. View this article in WRRO
Shah KM, Wilkinson JM & Gartland A (2015) Cobalt and chromium exposure affects osteoblast function and impairs the mineralization of prosthesis surfaces in vitro. Journal of Orthopaedic Research, 33(11), 1663-1670. View this article in WRRO
Shah KM, Quinn PD, Gartland A & Wilkinson JM (2015) Understanding the tissue effects of tribo-corrosion: Uptake, distribution, and speciation of cobalt and chromium in human bone cells. Journal of Orthopaedic Research, 33(1), 114-121.
Andrews RE, Shah KM, Wilkinson JM & Gartland A (2011) Effects of cobalt and chromium ions at clinically equivalent concentrations after metal-on-metal hip replacement on human osteoblasts and osteoclasts: Implications for skeletal health. Bone, 49(4), 717-723. View this article in WRRO

Preprints

Shah KM, Tattersall L, Hussain A, Macfarlane SC, Williamson A, Acosta-Martin AE, Erler JT, Ottewell PD & Gartland A () P2RX7 inhibition reduces breast cancer induced osteolytic lesions - implications for bone metastasis, Cold Spring Harbor Laboratory.

All publications

Journal articles

Gao J, Pei H, Lv F, Niu X, You Y, He L, Hu S, Shah KM, Liu M, Chen Y , Du B et al (2024) JD-312 – A novel small molecule that facilitates cartilage repair and alleviates osteoarthritis progression. Journal of Orthopaedic Translation, 44, 60-71.
Gao J, Pei H, Lv F, Niu X, You Y, He L, Hu S, Shah KM, Liu M, Chen Y , Du B et al (2024) Corrigendum to ‘JD-312 – A novel small molecule that facilitates cartilage repair and alleviates osteoarthritis progression’[Journal of Orthopaedic Translation 44 (2024) 60–71]. Journal of Orthopaedic Translation.
He L, Xu Z, Niu X, Li R, Wang F, You Y, Gao J, Zhao L, Shah KM, Fan J , Liu M et al (2023) Gprc5b promotes cartilage anabolism and inhibits catabolism by blocking autophagy signaling pathway. Knockout of Gprc5b suppresses cartilage anabolic factors and promotes catabolic factors. Acta Pharmaceutica Sinica B.
Green D, Singh A, Tippett VL, Tattersall L, Shah KM, Siachisumo C, Ward NJ, Thomas P, Carter S, Jeys L , Sumathi V et al (2023) YBX1-interacting small RNAs and RUNX2 can be blocked in primary bone cancer using CADD522. Journal of Bone Oncology, 39, 100474-100474.
Tattersall L, Gagui DC, Tippett VL, Latif NBA, Shah KM & Gartland A (2022) A systematic review of the expression, signalling and function of P2 receptors in primary bone cancer. Frontiers in Bioscience-Landmark, 27(4). View this article in WRRO
Jiang W, Jin Y, Zhang S, Ding Y, Huo K, Yang J, Zhao L, Nian B, Zhong TP, Lu W , Zhang H et al (2022) PGE2 activates EP4 in subchondral bone osteoclasts to regulate osteoarthritis. Bone Research, 10(1). View this article in WRRO
Jin Y, Liu Q, Chen P, Zhao S, Jiang W, Wang F, Li P, Zhang Y, Lu W, Zhong TP , Ma X et al (2022) A novel prostaglandin E receptor 4 (EP4) small molecule antagonist induces articular cartilage regeneration. Cell Discovery, 8(1). View this article in WRRO
Liu Y, Shah KM & Luo J (2021) Strategies for articular cartilage repair and regeneration. Frontiers in Bioengineering and Biotechnology, 9. View this article in WRRO
Tattersall L, Shah KM, Lath DL, Singh A, Down JM, De Marchi E, Williamson A, Di Virgilio F, Heymann D, Adinolfi E , Fraser WD et al (2021) The P2RX7B splice variant modulates osteosarcoma cell behaviour and metastatic properties. Journal of Bone Oncology, 31. View this article in WRRO
Shah KM, Dunning MJ, Gartland A & Wilkinson JM (2021) Distinct concentration-dependent molecular pathways regulate bone cell responses to cobalt and chromium exposure from joint replacement prostheses. International Journal of Molecular Sciences, 22(10). View this article in WRRO
Steinberg J, Southam L, Fontalis A, Clark MJ, Jayasuriya RL, Swift D, Shah KM, Brooks RA, McCaskie AW, Wilkinson JM & Zeggini E (2021) Linking chondrocyte and synovial transcriptional profile to clinical phenotype in osteoarthritis. Annals of the Rheumatic Diseases.
Steinberg J, Southam L, Roumeliotis TI, Clark MJ, Jayasuriya RL, Swift D, Shah KM, Butterfield NC, Brooks RA, McCaskie AW , Bassett JHD et al (2021) A molecular quantitative trait locus map for osteoarthritis. Nature Communications, 12. View this article in WRRO
Marino S, Carrasco G, Li B, Shah KM, Lath DL, Sophocleous A, Lawson MA & Idris AI (2020) JZL184, a monoacylglycerol lipase inhibitor, induces bone loss in a multiple myeloma model of immunocompetent mice. Calcified Tissue International. View this article in WRRO
MacInnes SJ, Hatzikotoulas K, Fenstad AM, Shah K, Southam L, Tachmazidou I, Hallan G, Dale H, Panoutsopoulou K, Furnes O , Zeggini E et al (2019) Erratum to: The 2018 Otto Aufranc Award: How Does Genome-wide Variation Affect Osteolysis Risk After THA?. Clinical Orthopaedics & Related Research, 477(3), 668-668.
MacInnes SJ, Hatzikotoulas K, Fenstad AM, Shah K, Southam L, Tachmazidou I, Hallan G, Dale H, Panoutsopoulou K, Furnes O , Zeggini E et al (2019) The 2018 Otto Aufranc Award: How Does Genome-wide Variation Affect Osteolysis Risk After THA?. Clinical Orthopaedics and Related Research, 477(2), 297-309. View this article in WRRO
Hatzikotoulas K, Roposch A, Case Control Consortium DDH, Shah KM, Clark MJ, Bratherton S, Limbani V, Steinberg J, Zengini E, Warsame K , Ratnayake M et al (2018) Genome-wide association study of developmental dysplasia of the hip identifies an association with GDF5. Communications Biology, 1. View this article in WRRO
Steinberg J, Ritchie GRS, Roumeliotis TI, Jayasuriya RL, Clark MJ, Brooks RA, Binch ALA, Shah KM, Coyle R, Pardo M , Le Maitre CL et al (2017) Integrative epigenomics, transcriptomics and proteomics of patient chondrocytes reveal genes and pathways involved in osteoarthritis. Scientific Reports, 7(1). View this article in WRRO
Steinberg J, Shah KM, Gartland A, Zeggini E & Wilkinson JM (2017) Effects of chronic cobalt and chromium exposure after metal-on-metal hip resurfacing: An epigenome-wide association pilot study. Journal of Orthopaedic Research, 35(10), 2323-2328. View this article in WRRO
Shah KM, Orton P, Mani N, Wilkinson JM & Gartland A (2016) Osteocyte physiology and response to fluid shear stress are impaired following exposure to cobalt and chromium: Implications for bone health following joint replacement.. Journal of Orthopaedic Research. View this article in WRRO
Shah KM, Stern MM, Stern AR, Pathak JL, Bravenboer N & Bakker AD (2016) Osteocyte isolation and culture methods.. BoneKEy Reports, 5. View this article in WRRO
Shah KM, Wilkinson JM & Gartland A (2015) Cobalt and chromium exposure affects osteoblast function and impairs the mineralization of prosthesis surfaces in vitro. Journal of Orthopaedic Research, 33(11), 1663-1670. View this article in WRRO
Shah KM, Quinn PD, Gartland A & Wilkinson JM (2015) Understanding the tissue effects of tribo-corrosion: Uptake, distribution, and speciation of cobalt and chromium in human bone cells. Journal of Orthopaedic Research, 33(1), 114-121.
Andrews RE, Shah KM, Wilkinson JM & Gartland A (2011) Effects of cobalt and chromium ions at clinically equivalent concentrations after metal-on-metal hip replacement on human osteoblasts and osteoclasts: Implications for skeletal health. Bone, 49(4), 717-723. View this article in WRRO
Lawrence SR & Shah KM () Prospects and Current Challenges of Extracellular Vesicle-Based Biomarkers in Cancer. Biology, 13(9), 694-694.
Tippett VL, Tattersall L, Ab Latif NB, Shah KM, Lawson MA & Gartland A () The strategy and clinical relevance of in vitro models of MAP resistance in osteosarcoma: a systematic review. Oncogene.
Hatzikotoulas K, Roposch A, Shah K, Clark M, Bratherton S, Limbani V, Steinberg J, Zengini E, Warsame K, Ratnayake M , Tselepi M et al () The Genetic Epidemiology of Developmental Dysplasia of the Hip: A Genome-Wide Association Study Harnessing National Clinical Audit Data.

Conference proceedings papers

Hatzikotoulas K, Roposch A, Shah KM, Clark MJ, Bratherton S, Limbani V, Warsame K, Ratnayake M, Tselepi M, Schwartzentruber J , Steinberg J et al (2017) National clinical audit data decodes the genetic architecture of developmental dysplasia of the hip. Osteoarthritis and Cartilage, Vol. 25 (pp S36-S37), 27 April 2017 - 30 April 2017. View this article in WRRO
Steinberg J, Ritchie G, Roumeliotis T, Jayasuriya R, Brooks R, Binch A, Shah K, Coyle R, Pardo M, Le Maitre C , Ramos Y et al (2017) Molecular phenotyping of patient chondrocytes reveals genes and pathways involved in osteoarthritis. Osteoarthritis and Cartilage, Vol. 25 (pp S209-S210)
Shah K, Quinn P, Wilkinson M & Gartland A (2012) SPECIATION AND DISTRIBUTION OF COBALT AND CHROMIUM IN OSTEOBLASTS AND OSTEOCLASTS USING MICROFOCUS X-RAY FLUORESCENCE AND X-RAY ABSORPTION NEAR-EDGE STRUCTURE. OSTEOPOROSIS INTERNATIONAL, Vol. 23 (pp S592-S592)
Shah K, Patel V, Wang N & Gartland A (2010) The Effect of ATP on cancer cell proliferation in vitro -involvement of multiple P2X Receptors. PURINERGIC SIGNALLING, Vol. 6(1) (pp 140-140)

Preprints

Shah KM, Tattersall L, Hussain A, Macfarlane SC, Williamson A, Acosta-Martin AE, Erler JT, Ottewell PD & Gartland A () P2RX7 inhibition reduces breast cancer induced osteolytic lesions - implications for bone metastasis, Cold Spring Harbor Laboratory.
Tattersall L, Shah KM, Lath DL, Singh A, Down JM, De Marchi E, Williamson A, Di Virgilio F, Heymann D, Adinolfi E , Fraser WD et al () The P2RX7B splice variant modulates osteosarcoma cell behaviour and metastatic properties.
Steinberg J, Southam L, Butterfield NC, Roumeliotis TI, Fontalis A, Clark MJ, Jayasuriya RL, Swift D, Shah KM, Curry KF , Brooks RA et al () Decoding the genomic basis of osteoarthritis, Cold Spring Harbor Laboratory.
Steinberg J, Ritchie GRS, Roumeliotis TI, Jayasuriya RL, Brooks RA, Binch ALA, Shah KM, Coyle R, Pardo M, Le Maitre CL , Ramos YFM et al () Integrative epigenomics, transcriptomics and proteomics of patient chondrocytes reveal genes and pathways involved in osteoarthritis, Cold Spring Harbor Laboratory.