Professor Julian Gunn

MA, MB, BChir, MD, MRCP

Clinical Medicine, School of Medicine and Population Health

Professor of Interventional Cardiology

Honorary Consultant Cardiologist

Insigneo Fellow

MED - Professor Julian Gunn
MED - Professor Julian Gunn
Profile picture of MED - Professor Julian Gunn
J.Gunn@sheffield.ac.uk
+44 114 215 9531
+44 114 271 4953 (NHS Secretary, Northern General Hospital)

Full contact details

Professor Julian Gunn
Clinical Medicine, School of Medicine and Population Health
K103, K Floor Medical School
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Profile

For enquiries, please contact – ClinMed-Operational@sheffield.ac.uk

I was trained in Medicine at Cambridge, and took junior hospital posts around England before being appointed Clinical Lecturer in Cardiology at the University of Sheffield in 1994. I was trained in Cardiology in Sheffield, and in coronary intervention by Professor David Cumberland.

I won the BCS Young Investigator of the Year in 1995. I was appointed Senior Lecturer in 2000 and became Reader in Interventional Cardiology in 2014 and Professor in 2016. I lead the Mathematical Modelling in Medicine group within the School of Medicine & Population Health, and Chair the Cardio-Respiratory Workgroup of the Insigneo Institute for in silico medicine.

Research interests

My higher degree was in the field of local coronary artery injury and healing, and my interests since then have exclusively centred on coronary artery disease (CAD), its endovascular treatment with percutaneous coronary intervention (PCI; angioplasty), the injury and healing resulting from that, and how we can improve upon the results of PCI.

This research has spanned basic research, in vivo experimentation, translation into clinical studies and clinical decision making. Increasingly I am focusing on the application of computer models of coronary artery disease to develop ‘virtual’ coronary physiology based upon the coronary angiogram.

I supervise Academic Clinical Fellows and students at BMedSci, MD and PhD level and welcome applications from students interested in undertaking projects in the field of computational modelling of coronary artery blood flow.


Current project

  • Computer modelling of coronary artery disease and blood flow
  • Clinical decision making in coronary artery disease
  • Complex percutaneous coronary interventions
  • Translational clinical trials in these areas
Publications

Show: Featured publications All publications

Journal articles

Preprints

All publications

Journal articles

Chapters

Conference proceedings papers

  • Taylor D, Saxton H, Halliday I, Newman T, Kassab G, Gunn J & Morris P (2024) BS54 A systematic review and meta-analysis of murray’s law in the coronary arterial circulation. Basic science RIS download Bibtex download
  • Taylor D, Gunn J, Halliday I, Narracott A, Gosling R, Morris P, Newman T & Saxton H (2024) 220 Sensitivity of computed coronary physiology to murray’s law of vascular scaling. Stable IHD/Prevention/Hypertension/Lipids RIS download Bibtex download
  • Elamin N, Nelson TA, Richardson JD, Adam Z, Krishnamurthy A, Iqbal J, Morgan KP, Hall IR, Rothman A, Parker WAE , Storey RF et al (2023) 71 Initial clinical experience with 6-hour enoxaparin regimen in opiate-treated patients undergoing primary percutaneous coronary intervention. Acute coronary syndromes & Interventional Cardiology RIS download Bibtex download
  • Haley H, Ghobrial M, Lawford P, Morris P, Hose DR, Gunn J & Gosling R (2023) 42 The role of angiography-derived (VIRTUAL) fractional flow reserve in the management of patients with acute coronary syndromes (ACS); the VIRTU4-ACS study. Acute coronary syndromes & Interventional Cardiology RIS download Bibtex download
  • Albaraikan A, Williams G, Morris P & Gunn J (2023) 52 Does physical activity change in patients undergoing PCI for chronic coronary syndrome?. Acute coronary syndromes & Interventional Cardiology RIS download Bibtex download
  • Albaraikan A, Williams G, Gosling R, Morris P & Gunn J (2023) 39 Does FFR-guided PCI result in improved absolute coronary blood flow?. Acute coronary syndromes & Interventional Cardiology RIS download Bibtex download
  • Aubiniere-Robb L, Morris P, Gunn J, Gosling R, Hose R, Rammohan V & Lawford P (2021) 33 Absolute coronary blood flow and microvascular resistance modelling in patients with coronary artery disease. Acute coronary syndromes & Interventional cardiology RIS download Bibtex download
  • Gosling R, Gunn E, Wei HL, Gu Y, Rammohan V, Hughes T, Hose DR, Lawford PV, Gunn JP & Morris PD (2021) Utilising clinical data to personlaise boundary conditions significantly improves the accuracy of angiography based virtual FFR. EUROPEAN HEART JOURNAL, Vol. 42 (pp 1074-1074) RIS download Bibtex download
  • Anand A, Cudmore S, Robertson S, Stephen J, Haga K, Weir CJ, Murray SA, Boyd K, Gunn J, Iqbal J , MacLullich A et al (2020) Frailty assessment and risk prediction by GRACE score in older patients with acute myocardial infarction. BMC Geriatrics, Vol. 20(1) RIS download Bibtex download
  • Premawardhana AD, Lodge A, Sachdev S, Karamanavi E, Kotecha D, Mariscalco G, Lees J, Rothman A, Gunn J, Samara-Ratna P & Adlam D (2020) NOVEL PERICARDIAL LEFT VENTRICULAR ASSIST DEVICE (PAL-VAD) ASSESSMENT VIA LARGE ANIMAL AND CADAVERIC MODELS. HEART, Vol. 106 (pp A61-A62) RIS download Bibtex download
  • Premawardhana D, Lodge A, Sachdev S, Karamanavi E, Kotecha D, Lees J, Rothman A, Gunn J, Samara-ratna P & Adlam D (2020) Novel Pericardial Left Ventricular Assist Device (PALVAD) Assessment via Large Animal and Cadaveric Models. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol. 76(17) (pp B77-B77) RIS download Bibtex download
  • Gosling R, Morris P, Lawford P, Hose R & Gunn J (2019) Virtual (computed) FFR and Virtual Coronary Intervention (VCI) vs angiography for guiding PCI: a virtual study.. Heart, Vol. 105(Suppl 6) (pp a45-a45). Manchester, UK, 3 June 2019 - 5 June 2019. View this article in WRRO RIS download Bibtex download
  • Preston HA, Stroud S, Lal K, Gosling R, Morris P, Lawford P, Hose DR & Gunn J (2019) Feasibility of Coronary Angiogram-based Computational Modelling of Fractional Flow Reserve in Everyday Practice. CIRCULATION, Vol. 140 RIS download Bibtex download
  • Sumaya W, Parker W, Judge HM, Hall IR, Orme RC, Adam Z, Richardson JD, Rothman AM, Morgan KP, Gunn JP & Storey RF (2019) Prolonged Enoxaparin Infusion in Patients Undergoing Primary Percutaneous Coronary Intervention Compared to Standard-of-care: A Single-centre Clinical Trial. CIRCULATION, Vol. 140 RIS download Bibtex download
  • Parker W, Gosling R, Churton A, Parviz Y, Iqbal J, Heppenstall J, Teare D & Gunn J (2018) P28 DOES MILD CORONARY ARTERY ATHEROSCLEROSIS PROGRESS AT SERIAL ANGIOGRAPHY?. Cardiovascular Research, Vol. 114(suppl_2) (pp S9-S9) RIS download Bibtex download
  • Son S, Gosling R, Morris P & Gunn J (2018) What will be the Impact of Virtual Coronary Physiology upon the Practice of Coronary Artery Bypass Grafting Surgery for Patients with Coronary Artery Disease?. International Journal of Surgery, Vol. 55 (pp S9-S9) RIS download Bibtex download
  • Banning AS, Gariety V, Mouniemne K, Janus J, Kelly M, Gunn JP & Gershlick AH (2017) 7 Pre-clinical studies in a novel side-branch stent. Heart, Vol. 103(Suppl 7) (pp a3) RIS download Bibtex download
  • Rothman A, Arnold N, Abou Hanna J, Rowland H, Poff B, Macdonald K, Nagy M, Panian T, Sundaram B, Pham P , Forouzan O et al (2017) P612Feasibility and safety of a wireless pulmonary artery pressure monitoring system in chronic porcine models of pulmonary hypertension. European Heart Journal, Vol. 38(suppl_1) View this article in WRRO RIS download Bibtex download
  • Sciola MI, Morris PD, Lawford PV, Hose DR & Gunn JP (2017) A novel mathematical signal processing application which automates and improves the accuracy of FFR assessment. EUROPEAN HEART JOURNAL, Vol. 38 (pp 183-184) View this article in WRRO RIS download Bibtex download
  • Morris P, Iqbal J & Gunn JP (2017) Restenosis in simultaneous kissing stents to treat unprotected left main stem coronary artery bifurcation disease: incidence and management. EUROPEAN HEART JOURNAL, Vol. 38 (pp 87-87) View this article in WRRO RIS download Bibtex download
  • Gosling R, Yazdani M, Parviz Y, Hall I, Grech E, Gunn J, Storey R & Iqbal J (2017) COMPARISON OF P2Y12 INHIBITORS FOR MORTALITY AND STENT THROMBOSIS IN PATIENTS WITH ACUTE CORONARY SYNDROMES: SINGLE CENTRE STUDY OF 10,793 CONSECUTIVE ‘REAL-WORLD’ PATIENTS. Journal of the American College of Cardiology, Vol. 69(11) (pp 1014-1014) RIS download Bibtex download
  • Horne A, Gunn J, Iqbal J, Morgan K, Hall I, West J, Grech E, Barmby D, Wheeldon N, Storey R & Richardson J (2016) 27 Impact of Culprit Versus Non-Culprit Angiography Strategy on Primary PCI Door to Balloon Times. Heart, Vol. 102(Suppl 6) (pp A18-A18) RIS download Bibtex download
  • Alfaidi M, Hughes M, Alizadeh T, Casbolt H, Chamberlain J, Mann BE, Francis SE, Iqbal J & Gunn J (2016) 160 Modulation of Myocardial Ischaemic Injury by Carbon Monoxide Releasing Molecule-A1 in a Porcine Model of Acute Reperfusion Infarction. Heart, Vol. 102(Suppl 6) (pp A114.2-A114), 6 June 2016 - 8 August 2016. RIS download Bibtex download
  • Yazdani MF, Sawh C, Rashid S, Gunn J & Richardson J (2016) The Impact of PRAMI Trial on Interventional Practice in ST-Segment Elevation Myocardial Infarction in a University Hospital. Journal of the American College of Cardiology, Vol. 67(13) (pp 111-111) View this article in WRRO RIS download Bibtex download
  • Morris P, Zwierzak I, Lawford P, Sir D, Hose R & Gunn J (2015) 209 The Development and Validation of anin silicoModel of Coronary Arterial Physiology for Diagnostic Use. Heart, Vol. 101(Suppl 4) (pp A115.1-A115) RIS download Bibtex download
  • Kunadian V, Qiu W, Ludman P, Redwood S, Curzen N, Stables R, Gunn J & Gershlick A (2014) Outcomes in patients with cardiogenic shock following percutaneous coronary intervention in the contemporary era: an analysis from the british cardiovascular intervention society (BCIS) database. EUROPEAN HEART JOURNAL, Vol. 35 (pp 1040-1040) RIS download Bibtex download
  • Cimen S, Hoogendoorn C, Morris PD, Gunn J & Frangi A (2014) Reconstruction of Coronary Trees from 3DRA Using a 3D+t Statistical Cardiac Prior. Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention, Vol. 2 (pp 619-626) RIS download Bibtex download
  • Çimen S, Hoogendoorn C, Morris PD, Gunn J & Frangi AF (2014) Reconstruction of coronary trees from 3DRA using a 3D+t statistical cardiac prior. Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention, Vol. 17 (pp 619-626) RIS download Bibtex download
  • Rothman AMK, Arnold N, Dawson S, Chang W, Suvarna K, Kiely D, Gunn J & Lawrie A (2014) Radio-Frequency Denervation Of The Pulmonary Artery Reduces Pulmonary Hypertension In An Acute Porcine Model. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 189 RIS download Bibtex download
  • Iqbal J, Rowe R, Zhang Y-J, Parviz Y, Morton AC, Grech E, Gunn JP & Storey RF (2014) Lower Mortality and Stent Thrombosis Rates Associated With Introduction of Potent P2Y12 Inhibitors in Patients With Acute Coronary Syndromes. CIRCULATION, Vol. 130 RIS download Bibtex download
  • Morton AC, Hossain R, Ecob R, Walker J, Gunn J, Judge HM & Storey RF (2013) Morphine Delays the Onset of Action of Prasugrel in Patients With Prior History of St Elevation Myocardial Infarction. CIRCULATION, Vol. 128(22) RIS download Bibtex download
  • Moretti C, Fenning S, Parviz Y, Gunn J, D'Ascenzo F, Giusto F, Gaita F, Lane N, Iqbal J, Denvir M & Study FATE-ACS (2013) Frailty assessment as a prognostic tool in elderly acute coronary syndrome patients to identify those approaching end-of-life: results from prospective multicenter fate-acs study. EUROPEAN HEART JOURNAL, Vol. 34 (pp 559-560) RIS download Bibtex download
  • Kidambi A, Mather AN, Uddin A, Motwani M, Ripley DP, Herzog B, Gunn J, Plein S & Greenwood JP (2013) RECIPROCAL ECG CHANGE IN ST-ELEVATION MYOCARDIAL INFARCTION IS ASSOCIATED WITH AREA AT RISK AND MYOCARDIAL SALVAGE FOLLOWING REVASCULARIZATION. HEART, Vol. 99 RIS download Bibtex download
  • Malkin CJ, Ghobrial MSA, Raina T, Siotia A, Morton AC & Gunn J (2012) IMPACT OF INCOMPLETE REVASCULARISATION IN PATIENTS UNDERGOING PCI FOR UNPROTECTED LEFT MAIN STEM STENOSIS. HEART, Vol. 98 (pp A28-A28) RIS download Bibtex download
  • Morris PD, Ryan DR, Lycett R, Morton AC, Lawford PV, Hose DR & Gunn J (2012) COMPUTER MODELLED CORONARY PHYSIOLOGY AND "VIRTUAL" FRACTIONAL FLOW RESERVE FROM ROTATIONAL ANGIOGRAPHY. HEART, Vol. 98 (pp A14-A14) RIS download Bibtex download
  • Cardenes R, Novikov A, Gunn J, Hose R & Frangi AF (2012) 3D reconstruction of coronary arteries from rotational X-ray angiography. Proceedings - International Symposium on Biomedical Imaging (pp 618-621) RIS download Bibtex download
  • Gunn J, Ghobrial M, Raina T, Malkin C, Siotia A & Morton AC (2011) SYNTAX Score Does Not Add to Clinical Risk Score in a Typical PCI Population. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol. 58(20) (pp B111-B111) RIS download Bibtex download
  • Gunn J, Siotia A, Malkin C, Raina T & Morton AC (2011) Left Main Bifurcation Stenting: Long Term Followup of Simultaneous Kissing Stents in 140 Consecutive, Unselected Patients. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol. 58(20) (pp B84-B84) RIS download Bibtex download
  • Morris PD, Ryan DM, Lycett R, Morton AC, Lawford PV, Hose DR & Gunn JP (2011) Virtual Coronary Physiology and Anatomy Derived From Rotational Angiography: The First Step. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol. 58(20) (pp B189-B189) RIS download Bibtex download
  • Morton AC, Foley C, Rothman A, Gunn J, Greenwood JP, Hall A, Fox K, Lees B, Flather M & Crossman D (2011) INVESTIGATION OF IL-1 INHIBITION IN PATIENTS PRESENTING WITH NON-ST ELEVATION MYOCARDIAL INFARCTION ACUTE CORONARY SYNDROMES (THE MRC ILA HEART STUDY). HEART, Vol. 97 (pp A13-A13) RIS download Bibtex download
  • Kelly DJ, Mecinovic J, Arnold N, Suvarna K, Schofield CJ, Gunn J & Gershlick AH (2010) UPREGULATION OF HYPDXIA-INDUCIBLE FACTOR 1 alpha BY DI-METHYL OXALYL GLYCINE PROMOTES ANGIOGENESIS WITHIN ISCHAEMIC MYOCARDIUM IN A PORCINE CORONARY OCCLUSION MODEL. HEART, Vol. 96 (pp A61-A62) RIS download Bibtex download
  • Malkin CJ, Raina T, Morton AC & Gunn JP (2010) LEFT MAIN STEM PCI: 'REAL WORLD' LONG-TERM RESULTS IN A CONSECUTIVE SERIES OF 302 PATIENTS. HEART, Vol. 96 (pp A59-A60) RIS download Bibtex download
  • Malkin CJ & Gunn JP (2009) Complete Versus Incomplete Revascularisation In A 'Real World', Consecutive Population Of 241 Patients With Triple Vessel Coronary Artery Disease Undergoing Percutaneous Intervention. AMERICAN JOURNAL OF CARDIOLOGY, Vol. 104(6A) (pp 203D-203D) RIS download Bibtex download
  • Siotia AK, Morton AC & Gunn JP (2009) Simultaneous Kissing Paclitaxel-eluting Stents to Treat Unprotected Left Main Stem Bifurcation Disease: Medium Term Outcome In 140 Consecutive Patients. AMERICAN JOURNAL OF CARDIOLOGY, Vol. 104(6A) (pp 105D-105D) RIS download Bibtex download
  • Chamberlain J, Wheatcroft M, Arnold N, Francis S, Lupton H & Gunn J (2009) A NOVEL MURINE MODEL OF STENTING. HEART, Vol. 95 (pp A37-A38) RIS download Bibtex download
  • Caiazzo A, Evans D, Falcone JL, Hegewald J, Lorenz E, Stahl B, Wang D, Bernsdorf J, Chopard B, Gunn J , Hose R et al (2009) Towards a complex automata multiscale model of in-stent restenosis. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), Vol. 5544 LNCS(PART 1) (pp 705-714) RIS download Bibtex download
  • Evans DJW, Caiazzo A, Falcone JL, Hegewald J, Lorenz E, Stahl B, Wang D, Bernsdorf J, Chopard B, Gunn J , Walker D et al (2009) COAST: Modelling Restenosis and Stent Based Therapies. INTERNATIONAL CONFERENCE ON ADVANCEMENTS OF MEDICINE AND HEALTH CARE THROUGH TECHNOLOGY, Vol. 26 (pp 319-322) RIS download Bibtex download
  • Sillano D, Chieffo A, Colombo A, Vecchio S, Margheri M, Gunn J, Liistro FS, Bolognese L, Lee MS, Tobis J , Moretti C et al (2008) Incidence And Outlook Of Recurrent Restenosis After Treatment Of Unprotected Left Main Disease With Drug-Eluting Stents: Cohort Study On 718 Patients And 70 Restenotic Cases. AMERICAN JOURNAL OF CARDIOLOGY, Vol. 102(8A) (pp 117I-117I) RIS download Bibtex download
  • Morton AC, Siotia A & Gunn J (2008) Left main stem percutaneous coronary intervention: The first 250 patients from the Sheffield unselected, consecutive registry. HEART, Vol. 94 (pp A132-A132) RIS download Bibtex download
  • Taylor JC, Heppenstall J, Bowles J & Gunn J (2008) Is preprocedural rotational angiography superior to conventional, single-plane angiography for planning percutaneous coronary intervention?. HEART, Vol. 94 (pp A40-A40) RIS download Bibtex download
  • Gunn J & Briffa N (2008) Coronary artery bypass grafting and percutaneous coronary intervention for left main stem coronary artery disease: synergy in a real-world registry. HEART, Vol. 94 (pp A30-A31) RIS download Bibtex download
  • Kelly DJS, Morton AC, Raina T, Lupton H, Arnold A, Gunn J & Gershlick AH (2008) A porcine endovascular model of a chronic total coronary artery occlusion. HEART, Vol. 94 (pp A46-A46) RIS download Bibtex download
  • Kelly DJ, Mecinovic J, Schofield CJ, Gunn J & Gershlick AH (2008) Evidence for a potential new method of therapeutic angiogenesis: Increased endothelial cell mobility and tubule formation in cell culture after stabilisation of hypoxia-inducible factor. HEART, Vol. 94 (pp A46-A47) RIS download Bibtex download
  • Kelly DJ, Mecinovic J, Schofield CJ, Gunn J, Gershlick AH & Chico T (2008) In-vivo observations on angiogenesis: Dose-dependent effects of the prolyl-4-hydroxylase inhibitor, di-methyl oxalyl-glycine, on arterial development in embryonic zebrafish. HEART, Vol. 94 (pp A47-A48) RIS download Bibtex download
  • Siotia AK, Morton A & Gunn JP (2008) Simultaneous kissing stents to treat left main bifurcation stenosis. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol. 51(10) (pp B47-B48) RIS download Bibtex download
  • Siotia A, Morton A & Gunn J (2007) Simultaneous kissing stents (shotgun stents) to treat left main bifurcation stenosis. HEART, Vol. 93 (pp A93-A93) RIS download Bibtex download
  • Morton AC, Siotia A & Gunn J (2006) Left Main Stem Percutaneous Coronary Intervention an unselected registry of all comers 2000-2005. EUROPEAN HEART JOURNAL, Vol. 27 (pp 929-929) RIS download Bibtex download
  • Morton AC, Francis SE, Arnold ND, Gunn J, Dower S & Crossman D (2006) The effect of Interleukin-1 receptor antagonist on restenosis - continued suppression of neointima at 90 days. EUROPEAN HEART JOURNAL, Vol. 27 (pp 230-231) RIS download Bibtex download
  • Siotia A, Mofidi S, Morton A, Wales C, Newman C & Gunn J (2006) The impact of a policy of selective drug eluting stent implantation upon clinical resteosis: A 'real world' registry. HEART, Vol. 92 (pp A98-A98) RIS download Bibtex download
  • Siotia A, Morton A & Gunn J (2006) Shotgun stenting of left main bifurcation stenosis. HEART, Vol. 92 (pp A99-A99) RIS download Bibtex download
  • Ali Z, Alp N, Lupton H, Arnold N, Wheatcroft M, Hu Y, Greaves D, Gunn J & Channon K (2006) In-stent stenosis in apolipoprotein-E knockout mice: A novel mouse model of balloon angioplasty and stenting. HEART, Vol. 92 (pp A113-A113) RIS download Bibtex download
  • Siotia AK, Morton AC & Gunn JP (2006) Shotgun stenting of left main bifurcation stenosis. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol. 47(4) (pp 15B-15B) RIS download Bibtex download
  • Wheatcroft M, Lupton H, Arnold N, Francis S & Gunn J (2005) A new murine model of arterial stenting. HEART, Vol. 91 (pp A51-A51) RIS download Bibtex download
  • Akowuah E, Gray C, Sheridon P, Bettinger T, Res B, Brisken A, Gunn J, Crossman D, Francis S, Baker A & Newman C (2004) Ultrasound-mediated delivery of TIMP-3 plasmid DNA into saphenous vein leads to increased lumen size in a porcine interposition graft model. CIRCULATION, Vol. 110(17) (pp 161-161) RIS download Bibtex download
  • Morton AC, Varcoe R, Francis SE, Dower S, Arnold ND, Gunn J & Crossman DC (2004) Interleukin 1 receptor antagonist (IL 1ra) modulates the response to oversized balloon angioplasty and stenting in a porcine coronary artery model. HEART, Vol. 90 (pp A1-A2) RIS download Bibtex download
  • Morton AC, Varcoe R, Francis SE, Dower S, Arnold ND, Gunn J & Crossman DC (2004) Interleukin-1 receptor antagonist (IL-1ra) modulates the porcine coronary arterial response to stenting. ATHEROSCLEROSIS, Vol. 174(1) (pp S4-S4) RIS download Bibtex download
  • Morton AC, Francis SE, Dower S, Arnold ND, Gunn J & Crossman DC (2003) Interleukin-1 receptor antagonist (IL-1ra) modulates the porcine coronary arterial response to oversized balloon angioplasty and stenting. CIRCULATION, Vol. 108(17) (pp 195-195) RIS download Bibtex download
  • Akowuah E, Gray C, Francis S, Gunn J, Bettinger T, Brisken A, Crossman D & Newman C (2003) Adjunctive ultrasound exposure enhances gene delivery to vascular smooth muscle cells in vitro and to ex vivo and in vivo porcine saphenous vein grafts. AMERICAN JOURNAL OF CARDIOLOGY, Vol. 92(6A) (pp 100L-100L) RIS download Bibtex download
  • Morton AC, Narracott A, Chan K, Arnold N, Crossman DC & Gunn J (2003) Restitution of a tubular lumen after stent implantation in porcine coronary arteries. AMERICAN JOURNAL OF CARDIOLOGY, Vol. 92(6A) (pp 208L-208L) RIS download Bibtex download
  • Chan KH, Armstrong J, Malik N, Cumberland DC, Gunn J & Holt CM (2003) Vascular delivery of antisense oligonucleotide to c-myc via coated stents: In vitro and in vivo findings. HEART, Vol. 89 (pp A52-A53) RIS download Bibtex download
  • Morton A, Varcoe R, Beacock D, Crossman D & Gunn J (2003) Same-session discharge after PCI. HEART, Vol. 89 (pp A18-A18) RIS download Bibtex download
  • Chan KH, Armstrong J, Arnold N, Malik N, Crossman D, Gunn J & Holt CM (2002) In vivo pharmacokinetics and bioactivity of stent-based delivery of antisense oiligonucleotides to c-myc. AMERICAN JOURNAL OF CARDIOLOGY, Vol. 90(6A) (pp 123H-123H) RIS download Bibtex download
  • Morton A & Gunn J (2002) Stenting the stent. AMERICAN JOURNAL OF CARDIOLOGY, Vol. 90(6A) (pp 91H-91H) RIS download Bibtex download
  • Morton A, Wales C, Newman C, Crossman D, Cumberland D & Gunn J (2002) Drug-eluting stents: Maximizing benefit and minimizing costs.. AMERICAN JOURNAL OF CARDIOLOGY, Vol. 90(6A) (pp 71H-71H) RIS download Bibtex download
  • Richardson G, Gunn J, Morton AC, Greenwald SE, Benjamin N & Rothman MT (2002) A polymer-based copper coating generates nitric oxide from s-nitrosoglutathione but does not induce significant neointimal formation when used as a stent coating.. AMERICAN JOURNAL OF CARDIOLOGY, Vol. 90(6A) (pp 77H-77H) RIS download Bibtex download
  • Akowuah E, Morton A, Gray C, Zuk R, Crossman D, Gunn J & Newman C (2002) Endoluminal ultrasound enhances nonviral gene delivery from plasmid-coated stents.. AMERICAN JOURNAL OF CARDIOLOGY, Vol. 90(6A) (pp 118H-119H) RIS download Bibtex download
  • Richardson G, Gunn J, Morton AC, Greenwald SE, Benjamin N & Rothman MT (2002) A polymer-based copper coating can generate nitric oxide from S-nitrosoglutathione but does not induce significant neointimal formation. EUROPEAN HEART JOURNAL, Vol. 23 (pp 142-142) RIS download Bibtex download
  • Townsend CF, Francis SE, Chamberlain J, Gunn J, Crossman DC & Newman CMH (2001) Modulation of MSS1, a component of the 26S proteasome, in vascular smooth muscle cells in vitro and following experimental PTCA. EUR HEART J, Vol. 22 (pp 3-3) RIS download Bibtex download
  • Chico TJA, Gunn J, Arnold N, Bullens S, Lipari MT, Bunting S, Cumberland DC & Crossman DC (2000) Integrin αIIbβ3 and ανβ3 inhibition reduces neointima after porcine coronary angioplasty. Heart, Vol. 83(SUPPL. 1) RIS download Bibtex download
  • Chico TJA, Gunn J, Bullens SL, Arnold N, Bunting S, Cumberland DC & Crossman DC (1999) A selective integrin alpha V beta 3 antagonist reduces neointimal proliferation in a porcine coronary angioplasty model via a thrombus independent mechanism. CIRCULATION, Vol. 100(18) (pp 414-414) RIS download Bibtex download
  • Chico TJA, Gunn J, Arnold ND, Bullens S, Bunting S, Cumberland DC & Crossman DC (1999) Antagonists of integrins alpha IIb beta 3 and alpha v beta 3 reduce the neointimal response to arterial injury in a porcine coronary angioplasty model.. AM J CARDIOL, Vol. 84(6A) (pp 29P-30P) RIS download Bibtex download
  • Chamberlain J, Gunn J, Francis SE, Holt CM, Cumberland DC & Crossman DC (1998) IL-1 beta synthesis and neovascularisation following porcine coronary arterial injury. J VASC RES, Vol. 35(5) (pp 389-389) RIS download Bibtex download
  • Gunn J, Francis S, Holt C, Chamberlain J, Lambert D, Newman C, Crossman D & Cumberland D (1997) Is local drug delivery truly a low efficiency procedure?. AM J CARDIOL, Vol. 80 (pp TC240-TC240) RIS download Bibtex download

Website content

Preprints

Research group
  • Mr Marco Frison
  • Dr Becky Gosling (Staff Candidate)
  • Miss Martina Sciola
Grants

I currently hold NIHR, BHF and MRC-DPFS grants.

Teaching activities

I lecture to undergraduate medical students and enjoy bedside teaching. I also teach Cardiology trainees on a regional level. I am a trainer in PCI in Sheffield and lecture on advanced PCI techniques nationally and internationally.

I also teach on the Molecular Medicine MSc course. I have taught 21 BMedSci, 7 MD and 8 PhD students.

Professional activities and memberships

I am Honorary Consultant Cardiologist at the Sheffield Teaching Hospitals NHS Foundation Trust and Lead for Acute Coronary Syndrome Pathways, Sheffield Teaching Hospitals Foundation Trust.

I am Chairman of the Insigneo Cardiovascular Working Group. I am a member of the British Cardiovascular Society, and of the British Cardiovascular Intervention Society and its R&D committee.

I am a Supervisor for the Wellcome 4Ward North Clinical PhD Programme, and Member of the EPSRC Image-guided therapies UK Network. I am reviewer for six Cardiology journals and for the BHF, MRC and NIHR.