Professor Julian Gunn
MA, MB, BChir, MD, MRCP
Clinical Medicine, School of Medicine and Population Health
Professor of Interventional Cardiology
Honorary Consultant Cardiologist
Insigneo Fellow
J.Gunn@sheffield.ac.uk
+44 114 215 9531
+44 114 215 9531
+44 114 271 4953
(NHS Secretary, Northern General Hospital)
+44 114 271 1863
(fax)
K103, K Floor Medical School, The Medical School
Full contact details
Professor Julian Gunn
Clinical Medicine, School of Medicine and Population Health
K103, K Floor Medical School
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Clinical Medicine, School of Medicine and Population Health
K103, K Floor Medical School
The Medical School
Beech Hill Road
Sheffield
S10 2RX
- Profile
-
For enquiries, please contact – ClinMed-Operational@sheffield.ac.uk
I was trained in Medicine at Cambridge, and took junior hospital posts around England before being appointed Clinical Lecturer in Cardiology at the University of Sheffield in 1994. I was trained in Cardiology in Sheffield, and in coronary intervention by Professor David Cumberland.
I won the BCS Young Investigator of the Year in 1995. I was appointed Senior Lecturer in 2000 and became Reader in Interventional Cardiology in 2014 and Professor in 2016. I lead the Mathematical Modelling in Medicine group within the School of Medicine & Population Health, and Chair the Cardio-Respiratory Workgroup of the Insigneo Institute for in silico medicine.
- Research interests
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My higher degree was in the field of local coronary artery injury and healing, and my interests since then have exclusively centred on coronary artery disease (CAD), its endovascular treatment with percutaneous coronary intervention (PCI; angioplasty), the injury and healing resulting from that, and how we can improve upon the results of PCI.
This research has spanned basic research, in vivo experimentation, translation into clinical studies and clinical decision making. Increasingly I am focusing on the application of computer models of coronary artery disease to develop ‘virtual’ coronary physiology based upon the coronary angiogram.
I supervise Academic Clinical Fellows and students at BMedSci, MD and PhD level and welcome applications from students interested in undertaking projects in the field of computational modelling of coronary artery blood flow.
Current project
- Computer modelling of coronary artery disease and blood flow
- Clinical decision making in coronary artery disease
- Complex percutaneous coronary interventions
- Translational clinical trials in these areas
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- Incorporating clinical parameters to improve the accuracy of angiography-derived computed fractional flow reserve. European Heart Journal - Digital Health, 3(3), 481-488. View this article in WRRO
- Routine pressure wire assessment versus conventional angiography in the management of patients with coronary artery disease : the RIPCORD 2 Trial. Circulation. View this article in WRRO
- The complementary value of absolute coronary flow in the assessment of patients with ischaemic heart disease. Nature Cardiovascular Research. View this article in WRRO
- The use of digital coronary phantoms for the validation of arterial geometry reconstruction and computation of virtual FFR. Fluids, 7(6). View this article in WRRO
- Refining our understanding of the flow through coronary artery branches; revisiting Murray’s law in human epicardial coronary arteries. Frontiers in Materials, 13. View this article in WRRO
- The importance of three dimensional coronary artery reconstruction accuracy when computing virtual fractional flow reserve from invasive angiography.. Scientific Reports, 11. View this article in WRRO
- Virtual (computed) fractional flow reserve: future role in acute coronary syndromes. Frontiers in Cardiovascular Medicine, 8. View this article in WRRO
- The relationship between coronary stenosis morphology and fractional flow reserve: a computational fluid dynamics modelling study. European Heart Journal - Digital Health, 2(4), 616-625. View this article in WRRO
- The Impact of Virtual Fractional Flow Reserve and Virtual Coronary Intervention on Treatment Decisions in the Cardiac Catheter Laboratory. Canadian Journal of Cardiology, 37(10), 1530-1538. View this article in WRRO
- A novel method for measuring absolute coronary blood flow and microvascular resistance in patients with ischaemic heart disease. Cardiovascular Research, 117(6), 1567-1577. View this article in WRRO
- Operator-dependent variability of angiography-derived fractional flow reserve and the implications for treatment. European Heart Journal - Digital Health, 2(2), 263-270. View this article in WRRO
- The new role of diagnostic angiography in coronary physiological assessment. Heart, 107. View this article in WRRO
- Effect of side branch flow upon physiological indices in coronary artery disease. Journal of Biomechanics, 103. View this article in WRRO
- Virtual Coronary Intervention. A Treatment Planning Tool Based Upon the Angiogram. JACC: Cardiovascular Imaging, 12(5), 865-872. View this article in WRRO
- Personalised Fractional Flow Reserve: Novel Concept to Optimise Myocardial Revascularization.. EuroIntervention, 15(8), 707-713. View this article in WRRO
- The impact of Objective Mathematical Analysis during Fractional Flow Reserve measurement: results from the OMA-FFR study. Eurointervention, 14(8), 935-941. View this article in WRRO
- Predictive Physiological Modeling of Percutaneous Coronary Intervention – Is Virtual Treatment Planning the Future?. Frontiers in Physiology, 9, 1107-1107. View this article in WRRO
- Fast Virtual Fractional Flow Reserve Based Upon Steady-State Computational Fluid Dynamics Analysis: Results From the VIRTU-Fast Study. JACC: Basic to Translational Science, 2(4), 434-446. View this article in WRRO
Preprints
All publications
Journal articles
- Virtual physiological analysis of non-culprit disease in patients with STEMI and multivessel disease: a substudy of the COMPLETE trial. European Heart Journal, 45(Supplement_1).
- Evaluation of models of sequestration flow in coronary arteries—Physiology versus anatomy?. Computers in Biology and Medicine, 108299-108299.
- Sex differences in coronary microvascular resistance measured by a computational fluid dynamics model. Frontiers in Cardiovascular Medicine, 10.
- Wearable technology and the cardiovascular system: the future of patient assessment. The Lancet Digital Health, 5(7), e467-e476.
- Chromodynamic Lattice Boltzmann Method for the Simulation of Drops, Erythrocytes, and other Vesicles. Communications in Computational Physics, 33(1), 283-309.
- Quantifying myocardial blood flow and resistance using 4D-flow cardiac magnetic resonance imaging. Cardiology Research and Practice, 2023.
- Oral Presentation No. 84 Initial clinical experience with 6-hour enoxaparin regimen in opiate-treated patients undergoing primary percutaneous coronary intervention. Cardiovascular Research, 118(Supplement_2).
- Incorporating clinical parameters to improve the accuracy of angiography-derived computed fractional flow reserve. European Heart Journal - Digital Health, 3(3), 481-488. View this article in WRRO
- Routine pressure wire assessment versus conventional angiography in the management of patients with coronary artery disease : the RIPCORD 2 Trial. Circulation. View this article in WRRO
- The complementary value of absolute coronary flow in the assessment of patients with ischaemic heart disease. Nature Cardiovascular Research. View this article in WRRO
- The use of digital coronary phantoms for the validation of arterial geometry reconstruction and computation of virtual FFR. Fluids, 7(6). View this article in WRRO
- Refining our understanding of the flow through coronary artery branches; revisiting Murray’s law in human epicardial coronary arteries. Frontiers in Materials, 13. View this article in WRRO
- Invasive coronary physiology in patients with angina and non-obstructive coronary artery disease: a consensus document from the coronary microvascular dysfunction workstream of the British Heart Foundation/National Institute for Health Research Partnership. Heart.
- A NOVEL PREDICTIVE MODEL OF CORONARY ARTERIAL INLET, OUTLET AND SIDE-BRANCH BLOOD FLOW. Journal of the American College of Cardiology, 79(9), 2022-2022. View this article in WRRO
- The importance of three dimensional coronary artery reconstruction accuracy when computing virtual fractional flow reserve from invasive angiography.. Scientific Reports, 11. View this article in WRRO
- Virtual (computed) fractional flow reserve: future role in acute coronary syndromes. Frontiers in Cardiovascular Medicine, 8. View this article in WRRO
- The relationship between coronary stenosis morphology and fractional flow reserve: a computational fluid dynamics modelling study. European Heart Journal - Digital Health, 2(4), 616-625. View this article in WRRO
- Coronary Physiological Assessment in a Patient With Atrial Fibrillation. JACC: Cardiovascular Interventions, 14(15), 1731-1733.
- Three-dimensional single framework multicomponent lattice Boltzmann equation method for vesicle hydrodynamics. Physics of Fluids, 33(7), 077110-077110.
- The Impact of Virtual Fractional Flow Reserve and Virtual Coronary Intervention on Treatment Decisions in the Cardiac Catheter Laboratory. Canadian Journal of Cardiology, 37(10), 1530-1538. View this article in WRRO
- Extreme bradycardia as presentation of an eating disorder.. BMJ Case Rep, 14(6).
- A novel method for measuring absolute coronary blood flow and microvascular resistance in patients with ischaemic heart disease. Cardiovascular Research, 117(6), 1567-1577. View this article in WRRO
- Carbon monoxide releasing molecule A1 reduces myocardial damage after acute myocardial infarction in a porcine model. Journal of Cardiovascular Pharmacology, Publish Ahead of Print.
- Feasibility and validation of trans-valvular flow derived by four-dimensional flow cardiovascular magnetic resonance imaging in patients with atrial fibrillation. Wellcome Open Research, 6, 73.
- Preclinical testing of a novel pericardial left ventricular assist device (PALVAD). European Heart Journal Acute Cardiovascular Care, 10(Supplement_1), zuab020.035.
- A further explanation for chest pain without visible coronary artery disease. Clinical Medicine, 21(2), e242.1-e242.
- Operator-dependent variability of angiography-derived fractional flow reserve and the implications for treatment. European Heart Journal - Digital Health, 2(2), 263-270. View this article in WRRO
- The new role of diagnostic angiography in coronary physiological assessment. Heart, 107. View this article in WRRO
- TCT CONNECT-180 Novel Pericardial Left Ventricular Assist Device (PALVAD) Assessment via Large Animal and Cadaveric Models. Journal of the American College of Cardiology, 76(17), B77-B77.
- Effect of side branch flow upon physiological indices in coronary artery disease. Journal of Biomechanics, 103. View this article in WRRO
- Angiography‐derived fractional flow reserve : more or less physiology?. Journal of the American Heart Association, 9(6). View this article in WRRO
- Use of glycoprotein IIb/IIIa antagonists to prevent stent thrombosis in morphine-treated patients with ST-elevation myocardial infarction. Platelets. View this article in WRRO
- The double-kissing nano-crush for bifurcation lesions : development, bioengineering, fluid dynamics and initial clinical testing. Canadian Journal of Cardiology. View this article in WRRO
- 60 An atlas of computed FFR in common patterns of coronary artery disease. Heart, 105(Suppl 6), a51-a51. View this article in WRRO
- 17 Computational modelling of fractional flow reserve from coronary angiography : expert training required. Heart, 105(Suppl 6), a15-a15. View this article in WRRO
- 16 Assessing the accuracy of a novel in silico imaging tool for the 3D reconstruction of coronary vasculature in the context of virtual fractional flow reserve. Heart, 105(Suppl 6), a14-a14. View this article in WRRO
- Percutaneous or surgical revascularization for left main stem disease: NOBLE ideas, but do they EXCEL?. Expert Review of Cardiovascular Therapy, 17(5), 361-368.
- Virtual Coronary Intervention. A Treatment Planning Tool Based Upon the Angiogram. JACC: Cardiovascular Imaging, 12(5), 865-872. View this article in WRRO
- Transcatheter versus surgical intervention: lessons from trials of coronary revascularisation. Heart, 105(Suppl 2), s44-s49. View this article in WRRO
- Autoinflammatory constrictive pericarditis and chronic myelomonocytic leukaemia: when one speciality is not enough. BMJ Case Reports, 12(3). View this article in WRRO
- Development and validation of a novel risk score for primary percutaneous coronary intervention for ST elevation myocardial infarction. Cardiovascular Revascularization Medicine. View this article in WRRO
- Personalised Fractional Flow Reserve: Novel Concept to Optimise Myocardial Revascularization.. EuroIntervention, 15(8), 707-713. View this article in WRRO
- Simultaneous kissing stents to treat unprotected left main stem coronary artery bifurcation disease; stent expansion, vessel injury, hemodynamics, tissue healing, restenosis, and repeat revascularization.. Catheterization and Cardiovascular Interventions, 92(6), E381-E392. View this article in WRRO
- The impact of Objective Mathematical Analysis during Fractional Flow Reserve measurement: results from the OMA-FFR study. Eurointervention, 14(8), 935-941. View this article in WRRO
- Study of Two Dose Regimens of Ticagrelor Compared with Clopidogrel in Patients Undergoing Percutaneous Coronary Intervention for Stable Coronary Artery Disease (STEEL-PCI). Circulation, 138(13), 1290-1300. View this article in WRRO
- Predictive Physiological Modeling of Percutaneous Coronary Intervention – Is Virtual Treatment Planning the Future?. Frontiers in Physiology, 9, 1107-1107. View this article in WRRO
- P4616Frailty assessment and risk prediction by GRACE score in older patients with acute myocardial infarction. European Heart Journal, 39(suppl_1).
- Pharmacodynamic Effects of a 6-Hour Regimen of Enoxaparin in Patients Undergoing Primary Percutaneous Coronary Intervention (PENNY PCI Study). Thrombosis and Haemostasis, 118(07), 1250-1256. View this article in WRRO
- Computing Fractional Flow Reserve From Invasive Coronary Angiography. Circulation: Cardiovascular Interventions, 10(9). View this article in WRRO
- Fast Virtual Fractional Flow Reserve Based Upon Steady-State Computational Fluid Dynamics Analysis: Results From the VIRTU-Fast Study. JACC: Basic to Translational Science, 2(4), 434-446. View this article in WRRO
- P842A novel mathematical signal processing application which automates and improves the accuracy of FFR assessment. European Heart Journal, 38(suppl_1).
- Development and validation of a clinical risk score to predict mortality after percutaneous coronary intervention. Open Heart, 4. View this article in WRRO
- Prospective assessment of a palliative care tool to predict one-year mortality in patients with acute coronary syndrome. European Heart Journal: Acute Cardiovascular Care, 6(3), 272-279.
- Comparison of P2Y12 inhibitors for mortality and stent thrombosis in patients with acute coronary syndromes: Single center study of 10 793 consecutive ‘real-world’ patients. Platelets, 28(8), 767-773. View this article in WRRO
- DEVELOPMENT OF A NOVEL SIDE-BRANCH STENT: IN-VITRO STUDY. Journal of the American College of Cardiology, 69(11), 1065-1065.
- Endothelial repair in stented arteries is accelerated by inhibition of Rho-associated protein kinase. Cardiovascular Research, 112(3), 689-701. View this article in WRRO
- Rotational stent-ablation to treat under-expanded stents: Still the best method. International Journal of Cardiology, 223, 262-264.
- Simulation training for the trainee cardiologist: the evidence mounts. EuroIntervention, 11(13), 1454-1455. View this article in WRRO
- When is rotational angiography superior to conventional single-plane angiography for planning coronary angioplasty?. Catheterization and Cardiovascular Interventions, 87(4), E104-E112. View this article in WRRO
- Computational fluid dynamics modelling in cardiovascular medicine. Heart, 102(1), 18-28. View this article in WRRO
- Role of Animal Models in Coronary Stenting. Annals of Biomedical Engineering, 44(2), 453-465.
- Abstract 14086: Investigation of Inflammatory Markers and Cardiac Events Following Discontinuation of Interleukin-1 Receptor Antagonist in NSTE-ACS Patients. Circulation, 132(suppl_3).
- Pulmonary Artery Denervation Reduces Pulmonary Artery Pressure and Induces Histological Changes in an Acute Porcine Model of Pulmonary Hypertension. Circulation: Cardiovascular Interventions, 8(11), e002569-e002569. View this article in WRRO
- Impact of frailty on outcomes after percutaneous coronary intervention: a prospective cohort study. Open Heart, 2(1). View this article in WRRO
- Percutaneous brachial artery access for coronary artery procedures: Feasible and safe in the current era. Cardiovascular Revascularization Medicine, 16(8), 447-449.
- “Virtual” (Computed) Fractional Flow Reserve. JACC: Cardiovascular Interventions, 8(8), 1009-1017. View this article in WRRO
- Optimal Medical Therapy Improves Clinical Outcomes in Patients Undergoing Revascularization With Percutaneous Coronary Intervention or Coronary Artery Bypass Grafting. Circulation, 131(14), 1269-1277.
- Simulation in cardiology: state of the art. European Heart Journal, 36(13), 777-783.
- Coronary artery spasm: mimicry, misdiagnosis and misfortune. Case Reports, 2015(mar26 1), bcr2014204519-bcr2014204519.
- Repeat coronary angiography with previously normal arteries: a futile exercise?. Catheter Cardiovasc Interv, 85(3), 401-405.
- Outcomes in Patients With Cardiogenic Shock Following Percutaneous Coronary Intervention in the Contemporary Era. JACC: Cardiovascular Interventions, 7(12), 1374-1385.
- Abstract 20470: Lower Mortality and Stent Thrombosis Rates Associated With Introduction of Potent P2Y12 Inhibitors in Patients With Acute Coronary Syndromes. Circulation, 130(suppl_2).
- Coronary stents seeded with human trophoblastic endovascular progenitor cells show accelerated strut coverage without excessive neointimal proliferation in a porcine model. EuroIntervention, 10(6), 709-716.
- 292Endothelial cell forward migration in a disturbed wall shear stress environment is promoted by ROCK inhibition.. Cardiovasc Res, 103 Suppl 1, S53.
- Contribution of Mechanical and Fluid Stresses to the Magnitude of In-stent Restenosis at the Level of Individual Stent Struts. Cardiovascular Engineering and Technology, 5(2), 164-175.
- 219 Rock Inhibits Endothelial Migration in Disturbed flow Condition: A Potential Therapeutic Target in PCI.. Heart, 100 Suppl 3, A120.
- 77 Impact of frailty on length of hospital stay after percutaneous coronary intervention.. Heart, 100 Suppl 3, A45.
- 152 Stem Cell Coated Metallic Coronary Stents Show Accelerated Strut Coverage without Excessive Neointimal Proliferation in a Porcine Model.. Heart, 100 Suppl 3, A88-A89.
- 70 Risk Scoring Systems for PCI: Need for Geographical Validation and Temporal Calibration.. Heart, 100 Suppl 3, A41.
- Endothelial repair process and its relevance to longitudinal neointimal tissue patterns: comparing histology with in silico modelling.. J R Soc Interface, 11(94), 20140022.
- Abstract 521: Endothelial Cell Forward Migration in a Disturbed Wall Shear Stress Environment is Promoted by Rho-Kinase Inhibition. Arteriosclerosis, Thrombosis, and Vascular Biology, 34(suppl_1).
- From Histology and Imaging Data to Models for In-Stent Restenosis. The International Journal of Artificial Organs, 37(10), 786-800.
- Effect of eplerenone in percutaneous coronary intervention-treated post-myocardial infarction patients with left ventricular systolic dysfunction: a subanalysis of the EPHESUS trial.. Eur J Heart Fail, 16(6), 685-691.
- Role of frailty assessment in patients undergoing cardiac interventions. Open Heart, 1(1). View this article in WRRO
- The Effect of Interleukin-1 Receptor Antagonist Therapy on Markers of Inflammation in Non-ST Elevation Acute Coronary Syndromes: The MRC-ILA Heart Study. CIRCULATION, 128(22). View this article in WRRO
- Reciprocal ECG change in reperfused ST-elevation myocardial infarction is associated with myocardial salvage and area at risk assessed by cardiovascular magnetic resonance. Heart.
- Simulation of oxygen transfer in stented arteries and correlation with in-stent restenosis. International Journal for Numerical Methods in Biomedical Engineering, 29(12), 1373-1387.
- Frailty assessment as a prognostic tool in elderly acute coronary syndrome patients to identify those approaching end-of-life: results from prospective multicenter fate-acs study. European Heart Journal, 34(suppl 1), P3083-P3083.
- Frailty assessment in elderly people. LANCET, 381(9882), 1985-1986.
- Coronary stents: historical development, current status and future directions. BRITISH MEDICAL BULLETIN, 106(1), 193-211.
- Incidence and predictors of stent thrombosis: a single-centre study of 5,833 consecutive patients undergoing coronary artery stenting.. EuroIntervention, 9(1), 62-69.
- The effects of stenting on shear stress: relevance to endothelial injury and repair.. Cardiovasc Res, 99(2), 269-275.
- Reciprocal ECG change in ST-elevation myocardial infarction is associated with area at risk and myocardial salvage following revascularization. Journal of Cardiovascular Magnetic Resonance, 15(S1).
- ST elevation in ECG lead aVR signals severe acute left main coronary artery disease.. Acute Med, 12(4), 220-223.
- Residual SYNTAX score after PCI for triple vessel coronary artery disease: quantifying the adverse effect of incomplete revascularisation. EuroIntervention, 8, 1286-1295.
- Impact of incomplete revascularization in patients undergoing PCI for unprotected left main stem stenosis. Catheter Cardiovasc Interv, 81, 939-946.
- Virtual fractional flow reserve from coronary angiography: modeling the significance of coronary lesions: results from the VIRTU-1 (VIRTUal Fractional Flow Reserve From Coronary Angiography) study.. JACC Cardiovasc Interv, 6(2), 149-157.
- Poster Session 1. European Heart Journal: Acute Cardiovascular Care, 1(1_suppl), 18-55.
- MICRO-CT RENDERED IMAGES OF STENTED CORONARIES AND THE PHENOMENA OF IN-STENT RESTENOSIS. Journal of Biomechanics, 45, S145-S145.
- PP-203 ARE WE MISSING THE MOST SEVERE FORM OF ST ELEVATION: CASE SERIES FROM UK BASED PRIMARY PCI CENTRE. International Journal of Cardiology, 155, S167-S167.
- Contemporary management of ST-segment elevation myocardial infarction.. Hosp Pract (1995), 40(1), 224-231.
- A bridge too far. Heart, 98, 329.
- Simultaneous kissing drug-eluting stents to treat unprotected left main stem bifurcation disease: medium term outcome in 150 consecutive patients. EuroIntervention, 8, 691-700.
- Retrospective multicenter observational study of the interventional management of coronary disease in the very elderly: The NINETY. Catheter Cardiovasc Interv.
- Novel use of a pericardium-covered stent graft to treat bulky coronary artery thrombus.. Catheter Cardiovasc Interv, 80(1), 59-64.
- Multi-scale simulations of the dynamics of in-stent restenosis: impact of stent deployment and design. INTERFACE FOCUS, 1(3), 365-373.
- A Complex Automata approach for in-stent restenosis: Two-dimensional multiscale modelling and simulations. Journal of Computational Science.
- Myocardial infarction in a patient with down syndrome: a case report and review of the literature.. Clin Cardiol, 34(2), 87-89.
- - Activation of Hypoxia-Inducible Factor by Di-Methyl Oxalyl Glycine (DMOG) Increases Neovascularization within Ischaemic Myocardium in a Porcine Coronary Artery Occlusion Model, - 0, -.
- Novel use of a pericardium-covered stent graft to treat bulky coronary artery thrombus. Catheterization and Cardiovascular Interventions, 45(4).
- Hemodynamics and in-stent restenosis: micro-CT images, histology, and computer simulations.. Ann Biomed Eng, 39(10), 2615-2626.
- Hemodynamics and In-stent Restenosis: Micro-CT Images, Histology, and Computer Simulations. Annals of Biomedical Engineering, 1-12.
- UPREGULATION OF HYPOXIA-INDUCIBLE FACTOR BY DI-METHYL OXALYL GLYCINE (DMOG) INCREASES NEOVASCULARIZATION WITHIN ISCHAEMIC MYOCARDIUM IN A PORCINE CORONARY OCCLUSION MODEL. Journal of the American College of Cardiology, 55(10), A216.E2047-A216.E2047.
- Diagnosing an MI: don't trust the monitor!. Heart, 96, 408.
- A novel mouse model of in situ stenting.. Cardiovasc Res, 85(1), 38-44. View this article in WRRO
- Incidence and management of restenosis after treatment of unprotected left main disease with drug-eluting stents 70 restenotic cases from a cohort of 718 patients: FAILS (Failure in Left Main Study).. J Am Coll Cardiol, 54(13), 1131-1136.
- The final score: use of a sculpting balloon.. Heart, 95(17), 1448.
- A big cover-up. Heart, 95(16), 1354-1354.
- Intra-coronary alteplase for extensive coronary artery thrombus. Case Reports, 2009(feb16 1), bcr2006102392-bcr2006102392.
- The rock-hard stent sandwich. Heart, 95, 987.
- Prison break: getting a distal protection device out of jail. Heart, 95, 1308.
- The application of multiscale modelling to the process of development and prevention of stenosis in a stented coronary artery.. Philos Trans A Math Phys Eng Sci, 366(1879), 3343-3360.
- A novel porcine endovascular model of chronic coronary occlusion. EUROPEAN HEART JOURNAL, 29, 688-688.
- MULTISCALE MODELLING: APPLICATION OF THE COMPLEX AUTOMATA SIMULATION TECHNIQUE (COAST). Journal of Biomechanics, 41, S482-S482.
- Investigation of the effect of Interleukin-1 receptor antagonist (IL-1ra) on markers of inflammation in non-ST elevation acute coronary syndromes (The MRC-ILA-HEART Study).. Trials, 9, 8. View this article in WRRO
- A collaborative systematic review and meta-analysis on 1278 patients undergoing percutaneous drug-eluting stenting for unprotected left main coronary artery disease. American Heart Journal, 155(2), 274-283.
- Increased In-Stent Stenosis in ApoE Knockout Mice. Arteriosclerosis Thrombosis and Vascular Biology, 27(4), 833-840.
- Simultaneous kissing stent technique to treat left main stem bifurcation disease.. Catheter Cardiovasc Interv, 69(2), 209-215.
- Intra-coronary alteplase for extensive coronary artery thrombus. Heart, 93, 1262.
- Vascular delivery of c-myc antisense from cationically modified phosphorylcholine coated stents. Biomaterials, 28, 1218-1224.
- Acute myocardial infarction in young patients: the culprit is not always a ruptured atherosclerotic plaque. International Journal of Clinical Practice, 61, 1580-1582.
- Targeting drug-eluting stents to lesions at high risk of restenosis: a flawed approach?. Heart, 93, 251-252.
- Current challenges in coronary stenting: From bench to bedside. Biochemical Society Transactions, 35(5), 900-904.
- Increased in-stent stenosis in ApoE knockout mice: Insights from a novel mouse model of balloon angioplasty and stenting. Arteriosclerosis, Thrombosis, and Vascular Biology, 27(4), 833-840.
- Balloon folding affects the symmetry of stent deployment: Experimental and computational evidence. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, 3069-3073.
- Balloon folding affects the symmetry of stent deployment: experimental and computational evidence.. Conf Proc IEEE Eng Med Biol Soc, 2007, 3069-3073.
- Images in cardiology. The "butterfly" sign of the undilatable lesion.. Heart, 92(3), 404.
- A case of autotransfusion from pericardium to femoral vein. Heart, 92, 1727.
- Images in cardiology. Shotgun stenting of the left main coronary artery bifurcation. Heart, 92, 310.
- Risk scoring for percutaneous coronary intervention: let's do it!. Heart, 92, 1539-1540.
- Relative importance of the components of stent geometry to stretch induced in-stent neointima formation.. Heart, 91(12), 1603-1604.
- Interleukin-1 receptor antagonist alters the response to vessel wall injury in a porcine coronary artery model.. Cardiovasc Res, 68(3), 493-501.
- Ultrasound-mediated delivery of TIMP-3 plasmid DNA into saphenous vein leads to increased lumen size in a porcine interposition graft model.. Gene Ther, 12(14), 1154-1157.
- A thermal analogy for modelling drug elution from cardiovascular stents.. Comput Methods Biomech Biomed Engin, 7(5), 257-264.
- INTERLEUKIN-1 RECEPTOR ANTAGONIST (IL-1RA) MODULATES THE RESPONSE TO OVERSIZED BALLOON ANGIOPLASTY AND STENTING IN A PORCINE CORONARY ARTERY MODEL. Cardiovascular Pathology, 13(3), 93-93.
- Response of very small (2 mm) porcine coronary arteries to balloon angioplasty and stent implantation.. Heart, 90(3), 324-327.
- Interleukin-1 Receptor Antagonist (IL-1ra) Modulates the Porcine Coronary Arterial Response to Oversized Balloon Angioplasty and Stenting. Clinical Science, 106(s50), 2P-2P.
- The influence of physical stent parameters upon restenosis. Pathol Biol (Paris), 52, 196-205.
- Methotrexate eluting stents: to modify or cure?. Heart, 90, 121-122.
- Percutaneous coronary intervention and coronary artery bypass graft surgery have similar effects on health-related quality of life in people with medically refractory ischaemia at high risk of adverse effects. Evidence-based Cardiovascular Medicine, 7(4), 162-163.
- Investigation of the Knowledge and Awareness between Smoking and Diabetic Complications in a Diabetic Population. Clinical Science, 104(s48), 4P-5P.
- Position and Mobilisation Post-Angiograph Study (PAMPAS): a comparison of 4.5 hours and 2.5 hours bed rest. HEART, 89(4), 447-448.
- Measurement of the symmetry of in vitro stent expansion: a stereo-photogrammetric approach.. J Med Eng Technol, 27(2), 59-70.
- Drug eluting stents: maximising benefit and minimising cost.. Heart, 89(2), 127-131.
- Waiting lists: irritation or death sentence?. Lancet, 361, 2123.
- In-stent restenosis and atherosclerosis in a human saphenous vein graft. Heart, 89, 132.
- Revascularisation for acute coronary syndromes: PCI or CABG?. Heart, 89, 967-970.
- New developments in percutaneous coronary intervention. BMJ, 327, 150-153.
- Coronary artery stretch versus deep injury in the development of in-stent neointima.. Heart, 88(4), 401-405.
- Stenting the stent.. J Invasive Cardiol, 14(8), 447-451.
- Angiopeptin-eluting stents: observations in human vessels and pig coronary arteries.. J Invasive Cardiol, 14(5), 230-238.
- Increased intimal hyperplasia in experimental vein graft stenting compared to arterial stenting: Comparisons in a new rabbit model of stent injury. Cardiovascular Research, 56(1), 164-172.
- Localization of c-Myb and induction of apoptosis by antisense oligonucleotide c-Myb after angioplasty of porcine coronary arteries.. Arterioscler Thromb Vasc Biol, 21(11), 1727-1732.
- Increased intimal hyperplasia after experimental vein graft stenting compared to arterial stenting in a new rabbit model of stent injury. CIRCULATION, 104(17), 666-666.
- A new injury scoring system appropriate to mild/moderate stent injuries. CIRCULATION, 104(17), 743-743.
- Local delivery of angiopeptin from PC-coated stents.. AMERICAN JOURNAL OF CARDIOLOGY, 88(5A), 54G-54G.
- Importance of arterial deformation in the development of InStent neointima.. AMERICAN JOURNAL OF CARDIOLOGY, 88(5A), 52G-53G.
- Increased intimal hyperplasia after experimental vein graft stenting compared to arterial stenting: comparisons in a new rabbit model of stent injury. EUROPEAN HEART JOURNAL, 22, 280-280.
- Interleukin 1 receptor antagonist gene polymorphism and restenosis after coronary angioplasty.. Heart, 86(3), 336-340.
- TGFbeta is active, and correlates with activators of TGFbeta, following porcine coronary angioplasty.. Cardiovasc Res, 50(1), 125-136.
- Phosphorylcholine-coated stents in porcine coronary arteries: in vivo assessment of biocompatibility.. J Invasive Cardiol, 13(3), 193-201.
- Effect of selective or combined inhibition of integrins alpha(IIb)beta(3) and alpha(v)beta(3) on thrombosis and neointima after oversized porcine coronary angioplasty.. Circulation, 103(8), 1135-1141.
- Ultrasound as treatment for coronary artery disease. Echocardiography, 18, 213-217.
- Small stent, small vessel is not equivalent to standard stent, standard vessel.. AMERICAN JOURNAL OF CARDIOLOGY, 86(8A), 42I-42I.
- Are we achieving intended dimensions in stenting very small coronary arteries?. AMERICAN JOURNAL OF CARDIOLOGY, 86(8A), 42I-42I.
- Effects of arterial taper upon in-stent restenosis in very small coronary vessels.. AMERICAN JOURNAL OF CARDIOLOGY, 86(8A), 117I-117I.
- Interventional therapy on a coarctation of the aorta with a concomitant thoracic aneurysm using a stent graft. Z KARDIOL, 89(10), 962-964.
- Antisense delivery from phosphorylcholine (PC) coated stents. EUR HEART J, 21, 285-285.
- Anti-CD18 antibody blocks leucocyte trafficking in porcine coronary arteries following PTCA. EUR HEART J, 21, 284-284.
- Caspase-3 activity in porcine coronary arteries following PTCA. EUR HEART J, 21, 282-282.
- Possible different involvement of interleukin-1 receptor antagonist gene polymorphism in coronary single vessel disease and myocardial infarction - Response. CIRCULATION, 101(18), E193-E193.
- Antisense oligonucleotide to c-myb induces apoptosis in vascular smooth muscle cells in vitro and in vivo. Heart, 83(SUPPL. 1).
- Temporal and spatial distribution of interleukin-1 beta in balloon injured porcine coronary arteries.. Cardiovasc Res, 44(1), 156-165.
- Covered stent to treat co-existent coarctation and aneurysm of the aorta in a young man. Heart, 82(3), 351-351.
- Platelet glycoprotein IIb/IIIa inhibition by Lamifiban reduces the neointimal response to angioplasty in a porcine model. Heart, 81(SUPPL. 1).
- Local drug delivery from coronary stents in the porcine coronary artery. Heart, 81(SUPPL. 1).
- Interleukin-1 receptor antagonist gene polymorphism and coronary artery disease.. Circulation, 99(7), 861-866.
- New Developments in Therapeutic Ultrasound-Assisted Coronary Angioplasty. Curr Interv Cardiol Rep, 1, 281-290.
- Does stent design influence restenosis?. Eur Heart J, 20, 1009-1013.
- Stent coatings and local drug delivery; state of the art. Eur Heart J, 20, 1693-1700.
- Transforming growth factor-beta gene polymorphisms and coronary artery disease. CLIN SCI, 95(6), 659-667.
- Intravascular stents: a new technique for tissue processing for histology, immunohistochemistry, and transmission electron microscopy.. Heart, 80(5), 509-516.
- Overlapping stents: No alteration in neointima formation.. CIRCULATION, 98(17), 189-189.
- Apoptosis and cell proliferation after porcine coronary angioplasty.. Circulation, 98(16), 1657-1665.
- Aorto-ostial stent: Procedural, angiographic and histological evaluation in porcine coronary arteries.. AM J CARDIOL, 82(7A), 68S-68S.
- Assessment of the safety and efficacy of supersaturated oxygen solution: A novel method of reducing myocardial ischaemia in PTCA.. AM J CARDIOL, 82(7A), 100S-100S.
- Biomimicry 1: PC.. Semin Interv Cardiol, 3(3-4), 149-150.
- Phosphorylcholine coated stents: Angiographic and morphometric assessment in porcine coronary arteries. J AM COLL CARDIOL, 31(2), 414A-414A.
- Apoptosis and cell proliferation following porcine angioplasty. J AM COLL CARDIOL, 31(2), 22A-22A.
- Has stenting killed local drug delivery?. Eur Heart J, 19, 689-692.
- Interleukin-1 (IL-1) gene polymorphisms: Risk of coronary arterial disease. Heart, 79(SUPPL. 1).
- The BioDivYsio(R) stent: Morphometric superiority to the Palmaz-Schatz stent in the porcine coronary model. AMERICAN JOURNAL OF CARDIOLOGY, 80, TCT95-TCT95.
- The effect of oligonucleotides to c-myb on vascular smooth muscle cell proliferation and neointima formation after porcine coronary angioplasty.. Circ Res, 80(4), 520-531.
- In-stent restenosis: More metal and more symmetry required?. Heart, 77(SUPPL. 1).
- Restenosis after balloon angioplasty: Intimal hyperplasia or vessel remodelling?. HEART, 75(5), 88-88.
- Dual balloon catheter.. Semin Interv Cardiol, 1(1), 31-33.
- INTRA-CORONARY DRUG-DELIVERY VIA POROUS BALLOON - LOCAL OR REGIONAL. CIRCULATION, 92(8), 3220-3220.
- 793-4 Local Delivery of C-myb Antisense attenuates Neo-Intimal Thickening in a Porcine Model of Coronary Angioplasty. Journal of the American College of Cardiology, 25(2), 376A-377A.
- 760-4 Initial Multicenter Experience with Therapeutic Ultrasonic Coronary Angioplasty in Patients. Journal of the American College of Cardiology, 25(2), 268A-268A.
- ULTRASONIC ANGIOPLASTY FOR CHRONIC TOTAL CORONARY-ARTERY OCCLUSION. LANCET, 344(8931), 1225-1225.
- USE OF THERAPEUTIC ULTRASOUND IN PERCUTANEOUS CORONARY ANGIOPLASTY - EXPERIMENTAL IN-VITRO STUDIES AND INITIAL CLINICAL-EXPERIENCE. CIRCULATION, 89(4), 1587-1592.
- VARIABLE AND CIRCADIAN RESPONSE TO A FIXED HIGH-DOSE (12500IU TWICE-DAILY) SUBCUTANEOUS HEPARIN REGIMEN AFTER THROMBOLYTIC THERAPY FOR ACUTE MYOCARDIAL-INFARCTION. CORONARY ARTERY DISEASE, 5(3), 257-265.
- POTENTIAL ROLE OF THERAPEUTIC ULTRASOUND IN CORONARY ANGIOPLASTY (TUSCA). JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, A186-A186.
- THERAPEUTIC ULTRASONIC CORONARY ANGIOPLASTY - IMMEDIATE AND 24-HOUR QUANTITATIVE ANGIOGRAPHIC ASSESSMENT. CIRCULATION, 88(4), 645-645.
- THERAPEUTIC ULTRASONIC CORONARY ANGIOPLASTY - 1ST 20 CASES. CIRCULATION, 88(4), 296-296.
- A case of meningococcal endocarditis. European Heart Journal, 13, 1004-1005.
- Lymphoma presenting with Addison's disease. Postgrad Med J, 68, 229.
- Malignant thymoma causing tricuspid valve obstruction. Eur Heart J, 11, 854-856.
- BUTANE SNIFFING CAUSING VENTRICULAR FIBRILLATION. The Lancet, 333, 617.
- Hypertensive crisis and broad complex bradycardia after a single dose of monoamine oxidase inhibitor. BMJ, 298, 964.
- Computational modelling of cardiovascular pathophysiology to risk stratify commercial spaceflight. Nature Reviews Cardiology.
- Duration of triple antithrombotic therapy and clinical outcomes after percutaneous coronary intervention in atrial fibrillation. Expert Review of Cardiovascular Therapy, 1-7.
- A systematic review and meta-analysis of Murray's Law in the Coronary Arterial Circulation. American Journal of Physiology-Heart and Circulatory Physiology.
- Modelled impact of virtual fractional flow reserve in patients undergoing coronary angiography (VIRTU-4). Heart.
- Modelling The Hemodynamics of Coronary Ischemia. Fluids, 8(5), 159-159.
- Rapid virtual fractional flow reserve using 3D computational fluid dynamics. European Heart Journal - Digital Health.
- Validation of a novel numerical model to predict regionalised blood flow in the coronary arteries. European Heart Journal - Digital Health.
- Integrating particle tracking with computational fluid dynamics to assess haemodynamic perturbation by coronary artery stents. PLOS ONE, 17(7), e0271469-e0271469.
- Revascularisation for the proximal left anterior descending artery: special case or part of the package?. Heart.
- Feasibility and safety of a telemetric pulmonary artery pressure monitoring system in acute and chronic porcine models of pulmonary hypertension.
- The Impact of the ‘PRAMI’ Trial on Interventional Practice in Patients with ST Elevation Myocardial Infarction at a University Hospital. International Journal of Cardiovascular Research, 06(03).
- Coronary physiology derived from invasive angiography : will it be a game changer?. Interventional Cardiology Review, 15. View this article in WRRO
- Prolonged enoxaparin therapy compared with standard-of-care antithrombotic therapy in opiate-treated patients undergoing primary percutaneous coronary intervention. Platelets. View this article in WRRO
- Location-specific comparison between a 3D in-stent restenosis model and micro-CT and histology data from porcine in vivo experiments. Cardiovascular Engineering and Technology. View this article in WRRO
- Left ventricular blood flow kinetic energy is associated with the six-minute walk test and LV remodelling post valvular intervention in aortic stenosis.. Quantitative imaging in medicine and surgery.
Chapters
- New concepts in coronary physiological assessment, Practical Interventional Cardiology (pp. 109-123). CRC Press
- Left Main Stem Stenosis: How to Proceed, Complications of Percutaneous Coronary Intervention (pp. 91-98). Springer London
- Therapeutic Ultrasound in Percutaneous Coronary Angioplasty: Sheffield Experience, Developments in Cardiovascular Medicine (pp. 263-269). Springer US
- Delivery of Antisense Oligonucleotides to the Vascular Wall, Vascular Disease (pp. 401-416). Humana Press
Conference proceedings papers
- BS54 A systematic review and meta-analysis of murray’s law in the coronary arterial circulation. Basic science
- 220 Sensitivity of computed coronary physiology to murray’s law of vascular scaling. Stable IHD/Prevention/Hypertension/Lipids
- 71 Initial clinical experience with 6-hour enoxaparin regimen in opiate-treated patients undergoing primary percutaneous coronary intervention. Acute coronary syndromes & Interventional Cardiology
- 42 The role of angiography-derived (VIRTUAL) fractional flow reserve in the management of patients with acute coronary syndromes (ACS); the VIRTU4-ACS study. Acute coronary syndromes & Interventional Cardiology
- 52 Does physical activity change in patients undergoing PCI for chronic coronary syndrome?. Acute coronary syndromes & Interventional Cardiology
- 39 Does FFR-guided PCI result in improved absolute coronary blood flow?. Acute coronary syndromes & Interventional Cardiology
- 33 Absolute coronary blood flow and microvascular resistance modelling in patients with coronary artery disease. Acute coronary syndromes & Interventional cardiology
- Utilising clinical data to personlaise boundary conditions significantly improves the accuracy of angiography based virtual FFR. EUROPEAN HEART JOURNAL, Vol. 42 (pp 1074-1074)
- Frailty assessment and risk prediction by GRACE score in older patients with acute myocardial infarction. BMC Geriatrics, Vol. 20(1)
- NOVEL PERICARDIAL LEFT VENTRICULAR ASSIST DEVICE (PAL-VAD) ASSESSMENT VIA LARGE ANIMAL AND CADAVERIC MODELS. HEART, Vol. 106 (pp A61-A62)
- Novel Pericardial Left Ventricular Assist Device (PALVAD) Assessment via Large Animal and Cadaveric Models. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol. 76(17) (pp B77-B77)
- Virtual (computed) FFR and Virtual Coronary Intervention (VCI) vs angiography for guiding PCI: a virtual study.. Heart, Vol. 105(Suppl 6) (pp a45-a45). Manchester, UK, 3 June 2019 - 5 June 2019. View this article in WRRO
- Feasibility of Coronary Angiogram-based Computational Modelling of Fractional Flow Reserve in Everyday Practice. CIRCULATION, Vol. 140
- Prolonged Enoxaparin Infusion in Patients Undergoing Primary Percutaneous Coronary Intervention Compared to Standard-of-care: A Single-centre Clinical Trial. CIRCULATION, Vol. 140
- P28 DOES MILD CORONARY ARTERY ATHEROSCLEROSIS PROGRESS AT SERIAL ANGIOGRAPHY?. Cardiovascular Research, Vol. 114(suppl_2) (pp S9-S9)
- What will be the Impact of Virtual Coronary Physiology upon the Practice of Coronary Artery Bypass Grafting Surgery for Patients with Coronary Artery Disease?. International Journal of Surgery, Vol. 55 (pp S9-S9)
- 7 Pre-clinical studies in a novel side-branch stent. Heart, Vol. 103(Suppl 7) (pp a3)
- P612Feasibility and safety of a wireless pulmonary artery pressure monitoring system in chronic porcine models of pulmonary hypertension. European Heart Journal, Vol. 38(suppl_1) View this article in WRRO
- A novel mathematical signal processing application which automates and improves the accuracy of FFR assessment. EUROPEAN HEART JOURNAL, Vol. 38 (pp 183-184) View this article in WRRO
- Restenosis in simultaneous kissing stents to treat unprotected left main stem coronary artery bifurcation disease: incidence and management. EUROPEAN HEART JOURNAL, Vol. 38 (pp 87-87) View this article in WRRO
- COMPARISON OF P2Y12 INHIBITORS FOR MORTALITY AND STENT THROMBOSIS IN PATIENTS WITH ACUTE CORONARY SYNDROMES: SINGLE CENTRE STUDY OF 10,793 CONSECUTIVE ‘REAL-WORLD’ PATIENTS. Journal of the American College of Cardiology, Vol. 69(11) (pp 1014-1014)
- 27 Impact of Culprit Versus Non-Culprit Angiography Strategy on Primary PCI Door to Balloon Times. Heart, Vol. 102(Suppl 6) (pp A18-A18)
- 160 Modulation of Myocardial Ischaemic Injury by Carbon Monoxide Releasing Molecule-A1 in a Porcine Model of Acute Reperfusion Infarction. Heart, Vol. 102(Suppl 6) (pp A114.2-A114), 6 June 2016 - 8 August 2016.
- The Impact of PRAMI Trial on Interventional Practice in ST-Segment Elevation Myocardial Infarction in a University Hospital. Journal of the American College of Cardiology, Vol. 67(13) (pp 111-111) View this article in WRRO
- 209 The Development and Validation of anin silicoModel of Coronary Arterial Physiology for Diagnostic Use. Heart, Vol. 101(Suppl 4) (pp A115.1-A115)
- Outcomes in patients with cardiogenic shock following percutaneous coronary intervention in the contemporary era: an analysis from the british cardiovascular intervention society (BCIS) database. EUROPEAN HEART JOURNAL, Vol. 35 (pp 1040-1040)
- Reconstruction of Coronary Trees from 3DRA Using a 3D+t Statistical Cardiac Prior. Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention, Vol. 2 (pp 619-626)
- Reconstruction of coronary trees from 3DRA using a 3D+t statistical cardiac prior. Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention, Vol. 17 (pp 619-626)
- Radio-Frequency Denervation Of The Pulmonary Artery Reduces Pulmonary Hypertension In An Acute Porcine Model. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 189
- Lower Mortality and Stent Thrombosis Rates Associated With Introduction of Potent P2Y12 Inhibitors in Patients With Acute Coronary Syndromes. CIRCULATION, Vol. 130
- Morphine Delays the Onset of Action of Prasugrel in Patients With Prior History of St Elevation Myocardial Infarction. CIRCULATION, Vol. 128(22)
- Frailty assessment as a prognostic tool in elderly acute coronary syndrome patients to identify those approaching end-of-life: results from prospective multicenter fate-acs study. EUROPEAN HEART JOURNAL, Vol. 34 (pp 559-560)
- RECIPROCAL ECG CHANGE IN ST-ELEVATION MYOCARDIAL INFARCTION IS ASSOCIATED WITH AREA AT RISK AND MYOCARDIAL SALVAGE FOLLOWING REVASCULARIZATION. HEART, Vol. 99
- IMPACT OF INCOMPLETE REVASCULARISATION IN PATIENTS UNDERGOING PCI FOR UNPROTECTED LEFT MAIN STEM STENOSIS. HEART, Vol. 98 (pp A28-A28)
- COMPUTER MODELLED CORONARY PHYSIOLOGY AND "VIRTUAL" FRACTIONAL FLOW RESERVE FROM ROTATIONAL ANGIOGRAPHY. HEART, Vol. 98 (pp A14-A14)
- 3D reconstruction of coronary arteries from rotational X-ray angiography. Proceedings - International Symposium on Biomedical Imaging (pp 618-621)
- SYNTAX Score Does Not Add to Clinical Risk Score in a Typical PCI Population. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol. 58(20) (pp B111-B111)
- Left Main Bifurcation Stenting: Long Term Followup of Simultaneous Kissing Stents in 140 Consecutive, Unselected Patients. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol. 58(20) (pp B84-B84)
- Virtual Coronary Physiology and Anatomy Derived From Rotational Angiography: The First Step. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol. 58(20) (pp B189-B189)
- INVESTIGATION OF IL-1 INHIBITION IN PATIENTS PRESENTING WITH NON-ST ELEVATION MYOCARDIAL INFARCTION ACUTE CORONARY SYNDROMES (THE MRC ILA HEART STUDY). HEART, Vol. 97 (pp A13-A13)
- UPREGULATION OF HYPDXIA-INDUCIBLE FACTOR 1 alpha BY DI-METHYL OXALYL GLYCINE PROMOTES ANGIOGENESIS WITHIN ISCHAEMIC MYOCARDIUM IN A PORCINE CORONARY OCCLUSION MODEL. HEART, Vol. 96 (pp A61-A62)
- LEFT MAIN STEM PCI: 'REAL WORLD' LONG-TERM RESULTS IN A CONSECUTIVE SERIES OF 302 PATIENTS. HEART, Vol. 96 (pp A59-A60)
- Complete Versus Incomplete Revascularisation In A 'Real World', Consecutive Population Of 241 Patients With Triple Vessel Coronary Artery Disease Undergoing Percutaneous Intervention. AMERICAN JOURNAL OF CARDIOLOGY, Vol. 104(6A) (pp 203D-203D)
- Simultaneous Kissing Paclitaxel-eluting Stents to Treat Unprotected Left Main Stem Bifurcation Disease: Medium Term Outcome In 140 Consecutive Patients. AMERICAN JOURNAL OF CARDIOLOGY, Vol. 104(6A) (pp 105D-105D)
- A NOVEL MURINE MODEL OF STENTING. HEART, Vol. 95 (pp A37-A38)
- Towards a complex automata multiscale model of in-stent restenosis. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), Vol. 5544 LNCS(PART 1) (pp 705-714)
- COAST: Modelling Restenosis and Stent Based Therapies. INTERNATIONAL CONFERENCE ON ADVANCEMENTS OF MEDICINE AND HEALTH CARE THROUGH TECHNOLOGY, Vol. 26 (pp 319-322)
- Incidence And Outlook Of Recurrent Restenosis After Treatment Of Unprotected Left Main Disease With Drug-Eluting Stents: Cohort Study On 718 Patients And 70 Restenotic Cases. AMERICAN JOURNAL OF CARDIOLOGY, Vol. 102(8A) (pp 117I-117I)
- Left main stem percutaneous coronary intervention: The first 250 patients from the Sheffield unselected, consecutive registry. HEART, Vol. 94 (pp A132-A132)
- Is preprocedural rotational angiography superior to conventional, single-plane angiography for planning percutaneous coronary intervention?. HEART, Vol. 94 (pp A40-A40)
- Coronary artery bypass grafting and percutaneous coronary intervention for left main stem coronary artery disease: synergy in a real-world registry. HEART, Vol. 94 (pp A30-A31)
- A porcine endovascular model of a chronic total coronary artery occlusion. HEART, Vol. 94 (pp A46-A46)
- Evidence for a potential new method of therapeutic angiogenesis: Increased endothelial cell mobility and tubule formation in cell culture after stabilisation of hypoxia-inducible factor. HEART, Vol. 94 (pp A46-A47)
- In-vivo observations on angiogenesis: Dose-dependent effects of the prolyl-4-hydroxylase inhibitor, di-methyl oxalyl-glycine, on arterial development in embryonic zebrafish. HEART, Vol. 94 (pp A47-A48)
- Simultaneous kissing stents to treat left main bifurcation stenosis. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol. 51(10) (pp B47-B48)
- Simultaneous kissing stents (shotgun stents) to treat left main bifurcation stenosis. HEART, Vol. 93 (pp A93-A93)
- Left Main Stem Percutaneous Coronary Intervention an unselected registry of all comers 2000-2005. EUROPEAN HEART JOURNAL, Vol. 27 (pp 929-929)
- The effect of Interleukin-1 receptor antagonist on restenosis - continued suppression of neointima at 90 days. EUROPEAN HEART JOURNAL, Vol. 27 (pp 230-231)
- The impact of a policy of selective drug eluting stent implantation upon clinical resteosis: A 'real world' registry. HEART, Vol. 92 (pp A98-A98)
- Shotgun stenting of left main bifurcation stenosis. HEART, Vol. 92 (pp A99-A99)
- In-stent stenosis in apolipoprotein-E knockout mice: A novel mouse model of balloon angioplasty and stenting. HEART, Vol. 92 (pp A113-A113)
- Shotgun stenting of left main bifurcation stenosis. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol. 47(4) (pp 15B-15B)
- A new murine model of arterial stenting. HEART, Vol. 91 (pp A51-A51)
- Ultrasound-mediated delivery of TIMP-3 plasmid DNA into saphenous vein leads to increased lumen size in a porcine interposition graft model. CIRCULATION, Vol. 110(17) (pp 161-161)
- Interleukin 1 receptor antagonist (IL 1ra) modulates the response to oversized balloon angioplasty and stenting in a porcine coronary artery model. HEART, Vol. 90 (pp A1-A2)
- Interleukin-1 receptor antagonist (IL-1ra) modulates the porcine coronary arterial response to stenting. ATHEROSCLEROSIS, Vol. 174(1) (pp S4-S4)
- Interleukin-1 receptor antagonist (IL-1ra) modulates the porcine coronary arterial response to oversized balloon angioplasty and stenting. CIRCULATION, Vol. 108(17) (pp 195-195)
- Adjunctive ultrasound exposure enhances gene delivery to vascular smooth muscle cells in vitro and to ex vivo and in vivo porcine saphenous vein grafts. AMERICAN JOURNAL OF CARDIOLOGY, Vol. 92(6A) (pp 100L-100L)
- Restitution of a tubular lumen after stent implantation in porcine coronary arteries. AMERICAN JOURNAL OF CARDIOLOGY, Vol. 92(6A) (pp 208L-208L)
- Vascular delivery of antisense oligonucleotide to c-myc via coated stents: In vitro and in vivo findings. HEART, Vol. 89 (pp A52-A53)
- Same-session discharge after PCI. HEART, Vol. 89 (pp A18-A18)
- In vivo pharmacokinetics and bioactivity of stent-based delivery of antisense oiligonucleotides to c-myc. AMERICAN JOURNAL OF CARDIOLOGY, Vol. 90(6A) (pp 123H-123H)
- Stenting the stent. AMERICAN JOURNAL OF CARDIOLOGY, Vol. 90(6A) (pp 91H-91H)
- Drug-eluting stents: Maximizing benefit and minimizing costs.. AMERICAN JOURNAL OF CARDIOLOGY, Vol. 90(6A) (pp 71H-71H)
- A polymer-based copper coating generates nitric oxide from s-nitrosoglutathione but does not induce significant neointimal formation when used as a stent coating.. AMERICAN JOURNAL OF CARDIOLOGY, Vol. 90(6A) (pp 77H-77H)
- Endoluminal ultrasound enhances nonviral gene delivery from plasmid-coated stents.. AMERICAN JOURNAL OF CARDIOLOGY, Vol. 90(6A) (pp 118H-119H)
- A polymer-based copper coating can generate nitric oxide from S-nitrosoglutathione but does not induce significant neointimal formation. EUROPEAN HEART JOURNAL, Vol. 23 (pp 142-142)
- Modulation of MSS1, a component of the 26S proteasome, in vascular smooth muscle cells in vitro and following experimental PTCA. EUR HEART J, Vol. 22 (pp 3-3)
- Integrin αIIbβ3 and ανβ3 inhibition reduces neointima after porcine coronary angioplasty. Heart, Vol. 83(SUPPL. 1)
- A selective integrin alpha V beta 3 antagonist reduces neointimal proliferation in a porcine coronary angioplasty model via a thrombus independent mechanism. CIRCULATION, Vol. 100(18) (pp 414-414)
- Antagonists of integrins alpha IIb beta 3 and alpha v beta 3 reduce the neointimal response to arterial injury in a porcine coronary angioplasty model.. AM J CARDIOL, Vol. 84(6A) (pp 29P-30P)
- IL-1 beta synthesis and neovascularisation following porcine coronary arterial injury. J VASC RES, Vol. 35(5) (pp 389-389)
- Is local drug delivery truly a low efficiency procedure?. AM J CARDIOL, Vol. 80 (pp TC240-TC240)
Website content
Preprints
- The Accuracy of Virtual Fractional Flow Reserve From Invasive Angiography: Importance of the Method of Reconstructing Three-dimensional Coronary Artery Anatomy, Research Square Platform LLC.
- Feasibility and validation of trans-valvular flow derived by four-dimensional flow cardiovascular magnetic resonance imaging in patients with atrial fibrillation.
- Incorporating clinical parameters to improve the accuracy of angiography-derived computed fractional flow reserve. European Heart Journal - Digital Health, 3(3), 481-488. View this article in WRRO
- Research group
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- Mr Marco Frison
- Dr Becky Gosling (Staff Candidate)
- Miss Martina Sciola
- Grants
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I currently hold NIHR, BHF and MRC-DPFS grants.
- Teaching activities
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I lecture to undergraduate medical students and enjoy bedside teaching. I also teach Cardiology trainees on a regional level. I am a trainer in PCI in Sheffield and lecture on advanced PCI techniques nationally and internationally.
I also teach on the Molecular Medicine MSc course. I have taught 21 BMedSci, 7 MD and 8 PhD students.
- Professional activities and memberships
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I am Honorary Consultant Cardiologist at the Sheffield Teaching Hospitals NHS Foundation Trust and Lead for Acute Coronary Syndrome Pathways, Sheffield Teaching Hospitals Foundation Trust.
I am Chairman of the Insigneo Cardiovascular Working Group. I am a member of the British Cardiovascular Society, and of the British Cardiovascular Intervention Society and its R&D committee.
I am a Supervisor for the Wellcome 4Ward North Clinical PhD Programme, and Member of the EPSRC Image-guided therapies UK Network. I am reviewer for six Cardiology journals and for the BHF, MRC and NIHR.