Dr James Meiring
MBChB, MRCP, PhD
Clinical Medicine, School of Medicine and Population Health
NIHR Clinical Lecturer in Infectious Diseases
+44 114 215 9518
Full contact details
Clinical Medicine, School of Medicine and Population Health
Royal Hallamshire Hospital
Glossop Road
Sheffield
S10 2JF
- Profile
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For enquiries please contact - ClinMed-Operational@sheffield.ac.uk
I originally came to Sheffield in 2003 for medical school. I stayed in South Yorkshire for my junior doctor jobs and then started specialist training in Infectious Diseases and Microbiology at Sheffield Teaching Hospitals. I went to Oxford University in 2015 to work on typhoid human challenge models and then got my PhD, based in Malawi studying typhoid epidemiology and vaccination in Africa and Asia. I have worked across Africa and Asia including the West Africa Ebola Virus Outbreak in 2014.
I am currently an academic clinical lecturer in the department of infection and immunity interested in measuring the vaccine preventable burden of infectious diseases in at-risk populations and using vaccines to prevent antimicrobial resistance.
- Qualifications
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- MBChB
- MRCP
- PhD
- Research interests
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My research interests are vaccination, AMR, epidemiology, sero-epidemiology, global health, enteric fever
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- Quality of antibody responses by adults and young children to 13-valent pneumococcal conjugate vaccination and streptococcus pneumoniae colonisation. Vaccine.
- Waning of antibody levels induced by a 13-valent pneumococcal conjugate vaccine, using a 3 + 0 schedule, within the first year of life among children younger than 5 years in Blantyre, Malawi: an observational, population-level, serosurveillance study. The Lancet Infectious Diseases.
- Hepatitis B Vaccination Impact and the Unmet Need for Antiviral Treatment in Blantyre, Malawi. The Journal of Infectious Diseases, 226(5), 871-880.
- Salmonella Typhi stool shedding by enteric fever patients and asymptomatic chronic carriers in an endemic urban setting.. Journal of Infectious Diseases, 224((Supplement_7)), S759-S763. View this article in WRRO
- Burden of enteric fever at three urban sites in Africa and Asia: a multicentre population-based study. The Lancet Global Health, 9(12), e1688-e1696. View this article in WRRO
- Safety and Efficacy of a Typhoid Conjugate Vaccine in Malawian Children. New England Journal of Medicine, 385(12), 1104-1115.
- A Bayesian approach for estimating typhoid fever incidence from large‐scale facility‐based passive surveillance data. Statistics in Medicine, 40(26), 5853-5870. View this article in WRRO
- The Surveillance for Enteric Fever in Asia Project (SEAP), Severe Typhoid Fever Surveillance in Africa (SETA), Surveillance of Enteric Fever in India (SEFI), and Strategic Typhoid Alliance Across Africa and Asia (STRATAA) population-based enteric fever studies: a review of methodological similarities and differences. Clinical Infectious Diseases, 71(Supplement_2), S102-S110. View this article in WRRO
- Generating the evidence for typhoid vaccine introduction: considerations for global disease burden estimates and vaccine testing through human challenge. Clinical Infectious Diseases, 69(Supplement_5), S402-S407. View this article in WRRO
- The invisible burden: diagnosing and combatting typhoid fever in Asia and Africa. Clinical Infectious Diseases, 69(Supplement_5), S395-S401. View this article in WRRO
- Typhoid vaccine acceleration consortium Malawi: a phase III, randomized, double-blind, controlled trial of the clinical efficacy of typhoid conjugate vaccine among children in Blantyre, Malawi. Clinical Infectious Diseases, 68(Supplement_2), S50-S58. View this article in WRRO
- Community engagement before initiation of typhoid conjugate vaccine trial in schools in two urban townships in Blantyre, Malawi: experience and lessons. Clinical Infectious Diseases, 68(Supplement_2), S146-S153. View this article in WRRO
- Efficacy and immunogenicity of a Vi-tetanus toxoid conjugate vaccine in the prevention of typhoid fever using a controlled human infection model of Salmonella Typhi: a randomised controlled, phase 2b trial. The Lancet, 390(10111), 2472-2480. View this article in WRRO
- The STRATAA study protocol: a programme to assess the burden of enteric fever in Bangladesh, Malawi and Nepal using prospective population census, passive surveillance, serological studies and healthcare utilisation surveys.. BMJ Open, 7(6), e016283-e016283. View this article in WRRO
All publications
Journal articles
- Global burden of bacterial antimicrobial resistance 1990–2021: a systematic analysis with forecasts to 2050. The Lancet, 404(10459), 1199-1226.
- Cognitive and psychiatric symptom trajectories 2–3 years after hospital admission for COVID-19: a longitudinal, prospective cohort study in the UK. The Lancet Psychiatry, 11(9), 696-708.
- Modelling Salmonella Typhi in high-density urban Blantyre neighbourhood, Malawi, using point pattern methods. Scientific Reports, 14(1), 17164.
- Pathogen diversity and antimicrobial resistance transmission of Salmonella enterica serovars Typhi and Paratyphi A in Bangladesh, Nepal, and Malawi: a genomic epidemiological study. The Lancet Microbe.
- Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease. Nature Immunology, 25(4), 607-621. View this article in WRRO
- Estimating the subnational prevalence of antimicrobial resistant Salmonella enterica serovars Typhi and Paratyphi A infections in 75 endemic countries, 1990–2019: a modelling study. The Lancet Global Health, 12(3), e406-e418.
- Evaluating the relationship between ciprofloxacin prescription and non-susceptibility in Salmonella Typhi in Blantyre, Malawi: an observational study. The Lancet Microbe.
- Efficacy of typhoid conjugate vaccine: final analysis of a 4-year, phase 3, randomised controlled trial in Malawian children. The Lancet, 403(10425), 459-468.
- Immunomodulatory therapy in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS, MIS-C; RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet Child & Adolescent Health, 8(3), 190-200.
- Accelarated immune ageing is associated with COVID-19 disease severity. Immunity & Ageing, 21(1), 6.
- Oral killed cholera vaccines for preventing cholera. Cochrane Database of Systematic Reviews, 2024(1), CD014573.
- 25 Exploring the views of infectious diseases and microbiology consultants in England on a novel delinked funding model for antimicrobials: The SMASH study. Clinical Infection in Practice, 20, 100290-100290.
- Empagliflozin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet Diabetes & Endocrinology. View this article in WRRO
- Long COVID research: an update from the PHOSP-COVID Scientific Summit. The Lancet Respiratory Medicine, 11(11), e93-e94.
- Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study. The Lancet Respiratory Medicine, 11(11), 1003-1019.
- The Challenge Non-Typhoidal Salmonella (CHANTS) Consortium: Development of a non-typhoidal Salmonella controlled human infection model: Report from a consultation group workshop, 05 July 2022, London, UK [version 2; peer review: 2 approved]. Wellcome Open Research, 8. View this article in WRRO
- Exploring the views of infection consultants in England on a novel delinked funding model for antimicrobials: the SMASH study. JAC-Antimicrobial Resistance, 5(4).
- Bacterial shedding and serologic responses following an outbreak of Salmonella Typhi in an endemic cohort. BMC Infectious Diseases, 23(1).
- Typhoid Fever: A Reduction and a Resurgence. The American Journal of Tropical Medicine and Hygiene.
- Determinants of recovery from post-COVID-19 dyspnoea: analysis of UK prospective cohorts of hospitalised COVID-19 patients and community-based controls. The Lancet Regional Health - Europe, 29. View this article in WRRO
- Longitudinal lung function assessment of patients hospitalised with COVID-19 using 1H and 129Xe lung MRI. Chest.
- Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study. eClinicalMedicine, 57, 101896-101896.
- The challenge non-typhoidal Salmonella (CHANTS) consortium: development of a non-typhoidal Salmonella controlled human infection model: report from a consultation group workshop, 05 July 2022, London, UK. Wellcome Open Research, 8.
- SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination. eBioMedicine, 87.
- Quality of antibody responses by adults and young children to 13-valent pneumococcal conjugate vaccination and streptococcus pneumoniae colonisation. Vaccine.
- Planetary health education and capacity building for healthcare professionals in a global context: current opportunities, gaps and future directions. International Journal of Environmental Research and Public Health, 19(18).
- 17 COVID-19 vaccine hesitancy among a UK cohort of patients living with HIV. Clinical Infection in Practice, 15(Supplement 1).
- 35 The clinical utility of microbiological culture and molecular testing of heart valves in surgically treated infective endocarditis. Clinical Infection in Practice, 15, 100196-100196.
- Waning of antibody levels induced by a 13-valent pneumococcal conjugate vaccine, using a 3 + 0 schedule, within the first year of life among children younger than 5 years in Blantyre, Malawi: an observational, population-level, serosurveillance study. The Lancet Infectious Diseases.
- Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY) : a randomised, controlled, open-label, platform trial and updated meta-analysis. The Lancet, 400(10349), 359-368.
- Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study. The Lancet Respiratory Medicine, 10(8), 761-775.
- Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet, 399(10325), 665-676.
- A clinical and molecular epidemiological survey of hepatitis C in Blantyre, Malawi, suggests a historic mechanism of transmission. Journal of Viral Hepatitis, 29(4), 252-262.
- Aspirin in patients admitted to hospital with COVID-19 (RECOVERY) : a randomised, controlled, open-label, platform trial. The Lancet, 399(10320), 143-151.
- Hepatitis B Vaccination Impact and the Unmet Need for Antiviral Treatment in Blantyre, Malawi. The Journal of Infectious Diseases, 226(5), 871-880.
- Salmonella Typhi stool shedding by enteric fever patients and asymptomatic chronic carriers in an endemic urban setting.. Journal of Infectious Diseases, 224((Supplement_7)), S759-S763. View this article in WRRO
- Burden of enteric fever at three urban sites in Africa and Asia: a multicentre population-based study. The Lancet Global Health, 9(12), e1688-e1696. View this article in WRRO
- Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study.. The Lancet Respiratory Medicine, 9(11), 1275-1287.
- Safety and Efficacy of a Typhoid Conjugate Vaccine in Malawian Children. New England Journal of Medicine, 385(12), 1104-1115.
- A Bayesian approach for estimating typhoid fever incidence from large‐scale facility‐based passive surveillance data. Statistics in Medicine, 40(26), 5853-5870. View this article in WRRO
- Parallel Sessions. Journal of Hepatology, 75, S205-S293.
- Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial. The Lancet, 397(10289), 2049-2059.
- Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet, 397(10285), 1637-1645.
- Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. Lancet, 397(10274), 605-612.
- Electronic data capture for large scale typhoid surveillance, household contact tracing, and health utilisation survey: Strategic Typhoid Alliance across Africa and Asia [version 2; peer review: 2 approved, 2 approved with reservations]. Wellcome Open Research, 5. View this article in WRRO
- Evaluation of hepatitis B virus (HBV) epidemiology, vaccine impact and treatment eligibility: a census-based community serological survey in Blantyre, Malawi. Journal of Hepatology, 73, S790-S790.
- The Surveillance for Enteric Fever in Asia Project (SEAP), Severe Typhoid Fever Surveillance in Africa (SETA), Surveillance of Enteric Fever in India (SEFI), and Strategic Typhoid Alliance Across Africa and Asia (STRATAA) population-based enteric fever studies: a review of methodological similarities and differences. Clinical Infectious Diseases, 71(Supplement_2), S102-S110. View this article in WRRO
- Evaluation of a standardised Vi poly-l-lysine ELISA for serology of Vi capsular polysaccharide antibodies. Biologicals, 66, 21-29.
- Generating the evidence for typhoid vaccine introduction: considerations for global disease burden estimates and vaccine testing through human challenge. Clinical Infectious Diseases, 69(Supplement_5), S402-S407. View this article in WRRO
- The invisible burden: diagnosing and combatting typhoid fever in Asia and Africa. Clinical Infectious Diseases, 69(Supplement_5), S395-S401. View this article in WRRO
- On the ground in Malawi—first typhoid conjugate vaccine study in Africa. The American Journal of Tropical Medicine and Hygiene, 100(6), 1299-1300. View this article in WRRO
- Typhoid vaccine acceleration consortium Malawi: a phase III, randomized, double-blind, controlled trial of the clinical efficacy of typhoid conjugate vaccine among children in Blantyre, Malawi. Clinical Infectious Diseases, 68(Supplement_2), S50-S58. View this article in WRRO
- Community engagement before initiation of typhoid conjugate vaccine trial in schools in two urban townships in Blantyre, Malawi: experience and lessons. Clinical Infectious Diseases, 68(Supplement_2), S146-S153. View this article in WRRO
- Typhoid conjugate vaccines: making vaccine history in Africa. Expert Review of Vaccines, 17(8), 673-676.
- Adjunctive rifampicin for Staphylococcus aureus bacteraemia (ARREST): a multicentre, randomised, double-blind, placebo-controlled trial. The Lancet, 391(10121), 668-678.
- Efficacy and immunogenicity of a Vi-tetanus toxoid conjugate vaccine in the prevention of typhoid fever using a controlled human infection model of Salmonella Typhi: a randomised controlled, phase 2b trial. The Lancet, 390(10111), 2472-2480. View this article in WRRO
- The Typhoid Vaccine Acceleration Consortium (TyVAC): Vaccine effectiveness study designs: Accelerating the introduction of typhoid conjugate vaccines and reducing the global burden of enteric fever. Report from a meeting held on 26–27 October 2016, Oxford, UK. Vaccine, 35(38), 5081-5088. View this article in WRRO
- The STRATAA study protocol: a programme to assess the burden of enteric fever in Bangladesh, Malawi and Nepal using prospective population census, passive surveillance, serological studies and healthcare utilisation surveys.. BMJ Open, 7(6), e016283-e016283. View this article in WRRO
- Typhoid fever. Nature Reviews Disease Primers, 9(1).
- Direct inference and control of genetic population structure from RNA sequencing data. Communications Biology, 6(1).
- Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study. The Lancet Respiratory Medicine.
- Higher dose corticosteroids in patients admitted to hospital with COVID-19 who are hypoxic but not requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet.
- Estimating the economic burden of typhoid in children and adults in Blantyre, Malawi: A costing cohort study. PLOS ONE, 17(11), e0277419-e0277419.
- Electronic data capture for large scale typhoid surveillance, household contact tracing, and health utilisation survey: Strategic Typhoid Alliance across Africa and Asia. Wellcome Open Research, 5, 66-66.
- A Typhoid Epidemic in Rural Malawi: Real-world Challenges. Annals of Global Health, 83(1), 67-67.
- Equalling inequality. BMJ, h5187-h5187.
Conference proceedings papers
- E018 COVID-19 vaccine-induced myositis. Rheumatology, Vol. 62(Supplement_2)
- COVID-19 VACCINE-INDUCED MYOSITIS. RHEUMATOLOGY, Vol. 62
- Lung Subtraction Iodine Mapping in Breathless Patients After COVID-19. C30. LIFE AND LUNGS AFTER COVID: FUNCTIONAL RECOVERY AND OUTCOMES FOLLOWING SARS-CoV2 INFECTION
- ESTIMATING THE ECONOMIC BURDEN OF TYPHOID IN CHILDREN AND ADULTS IN BLANTYRE, MALAWI: A COSTING COHORT STUDY. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, Vol. 105(5) (pp 106-107)
- A clinical and molecular epidemiological survey of hepatitis C in Blantyre, Malawi suggests an historic mechanism of transmission. JOURNAL OF HEPATOLOGY, Vol. 75 (pp S670-S671)
- Impaired xenon gas transfer observed one year after hospitalisation due to COVID-19 in patients with signs of interstitial lung disease.. ISMRM Annual Meeting, 3 June 2023 - 8 June 2023.
- Multinuclear lung MRI assessment of COVID-19 patients at 6 and 12 weeks after hospital admission. ISMRM Annual Meeting, 7 May 2022 - 12 May 2022.
Preprints
- Interplay Between the Gut Microbiome and Typhoid Fever: Insights from Endemic Countries and a Controlled Human Infection Model, Cold Spring Harbor Laboratory.
- The rapid emergence ofSalmonellaTyphi with decreased ciprofloxacin susceptibility following an increase in ciprofloxacin prescriptions in Blantyre, Malawi, Cold Spring Harbor Laboratory.
- Genomic epidemiology and antimicrobial resistance transmission ofSalmonellaTyphi and Paratyphi A at three urban sites in Africa and Asia, Cold Spring Harbor Laboratory.
- Efficacy of Typhoid Conjugate Vaccine: Final Analysis of a Four-Year, Randomised Controlled Trial in Malawian Children, Elsevier BV.
- Planetary Health Education and Capacity Building for Healthcare Professionals in Global Context: Current Opportunities, Gaps and Future Directions, MDPI AG.
- Waning of PCV13 vaccine-induced antibody levels within the first year of life, using a 3+0 schedule: an observational population-level serosurveillance study among children under 5 years old in Blantyre, Malawi, Cold Spring Harbor Laboratory.
- Longitudinal lung function assessment of patients hospitalised with COVID-19 using 1H and 129Xe lung MRI, Cold Spring Harbor Laboratory.
- Estimating the economic burden of typhoid in children and adults in Blantyre, Malawi: a costing cohort study, Research Square Platform LLC.
- Bacterial shedding and serologic responses following an outbreak of Salmonella Typhi in an endemic cohort, Cold Spring Harbor Laboratory.
- A Bayesian approach for estimating typhoid fever incidence from large-scale facility-based passive surveillance data, Cold Spring Harbor Laboratory.
- Electronic data capture for large scale typhoid surveillance, household contact tracing, and health utilisation survey: Strategic Typhoid Alliance across Africa and Asia, Cold Spring Harbor Laboratory.
- Electronic data capture for large scale typhoid surveillance, household contact tracing, and health utilisation survey: Strategic Typhoid Alliance across Africa and Asia, Research Square Platform LLC.
- Teaching interests
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I teach on the Diploma of Tropical Medicine and Hygiene in Sheffield. I also teach on the Clinical Neurosciences MsC, in addition to undergraduate medical student lectures and microbiology practicals.