Dr Irina-Alexandra Bacila

PhD, PGDip, MRCPCH

Clinical Medicine, School of Medicine and Population Health

Clinical Lecturer in Paediatrics

i.bacila@sheffield.ac.uk
+44 114 215 9022

EU10, E Floor, The Medical School

Full contact details

Dr Irina-Alexandra Bacila
Clinical Medicine, School of Medicine and Population Health
EU10, E Floor
The Medical School
Beech Hill Road
Sheffield
S10 2RX

Profile

For enquiries please contact - SMPH-West-Operational@sheffield.ac.uk

I joined the University of Sheffield in 2018 when I started a four-year post as Clinical Research Fellow in Paediatrics. This marked the beginning of my research activity within the Department of Oncology and Metabolism at The University of Sheffield and the Endocrine Team at Sheffield Children’s Hospital. During this time, I also completed a PhD in Endocrinology studying metabolic complications in congenital adrenal hyperplasia (CAH). I am dedicated to developing a career as a Clinical Academic, and I am currently working as a Clinical Lecturer in Paediatrics, dividing my time between academic work in the School of Medicine and Population Health, and clinical training in Paediatric Endocrinology at The Sheffield Children’s Hospital.

Qualifications

PhD in Endocrinology, The University of Sheffield, Sheffield (2023)
Postgraduate Diploma in Child Health, Leeds University, Leeds (2018)
Membership of the Royal College of Paediatrics and Child Health (MRCPCH) (2015)
Specialty Exam in Paediatrics, Cluj, Romania, Qualification: Specialty Doctor in Paediatrics (2012)
University of Medicine and Pharmacy, Cluj, Romania (2007)

Research interests: My research interests are adrenal disease, disorders of steroid synthesis and disorders of sexual development. I have explored these areas in clinical research involving patients with congenital adrenal hyperplasia (CAH) and also in Basic Science research, using zebrafish models of abnormal steroid synthesis. I am also interested in using bioinformatics in combination with metabolomics and transcriptomics to explore molecular mechanisms involved in the pathophysiology of endocrine and metabolic disease.

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Eachus H, Oberski L, Paveley J, Bacila I, Ashton J-P, Esposito U, Seifuddin F, Pirooznia M, Elhaik E, Placzek M , Krone N et al (2023) Glucocorticoid receptor regulates protein chaperone, circadian clock and affective disorder genes in the zebrafish brain. Disease Models & Mechanisms, 16(9). View this article in WRRO
Bacila I, Lawrence NR, Badrinath SG, Balagamage C & Krone NP (2023) Biomarkers in congenital adrenal hyperplasia. Clinical Endocrinology. View this article in WRRO
Lawrence NR, Bacila I, Dawson J, Mahdi S, Alvi S, Cheetham TD, Crowne E, Das U, Dattani MT, Davies JH , Gevers E et al (2023) Quality of Life in Children and Young People With Congenital Adrenal Hyperplasia—UK Nationwide Multicenter Assessment. The Journal of Clinical Endocrinology & Metabolism, 109(1), e336-e346.
Bacila I, Lawrence NR, Mahdi S, Alvi S, Cheetham TD, Crowne E, Das U, Dattani MT, Davies JH, Gevers E , Krone RE et al (2022) Health status of children and young persons with congenital adrenal hyperplasia in the UK (CAH-UK): a cross-sectional multi-centre study. European Journal of Endocrinology, 187(4), 543-553. View this article in WRRO
Lawrence N, Bacila I, Dawson J, Bryce J, Ali SR, van den Akker ELT, Bachega TASS, Baronio F, Birkebæk NH, Bonfig W , Claahsen van der Grinten H et al (2022) Analysis of therapy monitoring in the International Congenital Adrenal Hyperplasia Registry. Clinical Endocrinology, 97(5), 551-561. View this article in WRRO
Bacila I, Cunliffe VT & Krone NP (2021) Interrenal development and function in zebrafish. Molecular and Cellular Endocrinology, 535, 111372-111372.
Bacila I, Freeman N, Daniel E, Sandrk M, Bryce J, Ali SR, Yavas Abalı Z, Atapattu N, Bachega TA, Balsamo A , Birkebæk N et al (2021) International practice of corticosteroid replacement therapy in congenital adrenal hyperplasia - data from the I-CAH registry. European Journal of Endocrinology, 184(4), 553-563. View this article in WRRO
Bacila I, Adaway J, Hawley J, Mahdi S, Krone R, Patel L, Alvi S, Randell T, Gevers E, Dattani M , Cheetham T et al (2019) Measurement of Salivary Adrenal-Specific Androgens as Biomarkers of Therapy Control in 21-Hydroxylase Deficiency. The Journal of Clinical Endocrinology & Metabolism, 104(12), 6417-6429.
Bacila I-A, Elder C & Krone N (2019) Update on adrenal steroid hormone biosynthesis and clinical implications. Archives of Disease in Childhood, 104(12), 1223-1228. View this article in WRRO
Balagamage C, Lawrence NR, Krone R, Bacila IA & Krone NP () Blood Pressure in Children with Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency. Hormone Research in Paediatrics, 1-11.

All publications

Journal articles

Eachus H, Oberski L, Paveley J, Bacila I, Ashton J-P, Esposito U, Seifuddin F, Pirooznia M, Elhaik E, Placzek M , Krone N et al (2023) Glucocorticoid receptor regulates protein chaperone, circadian clock and affective disorder genes in the zebrafish brain. Disease Models & Mechanisms, 16(9). View this article in WRRO
Bacila I, Lawrence NR, Badrinath SG, Balagamage C & Krone NP (2023) Biomarkers in congenital adrenal hyperplasia. Clinical Endocrinology. View this article in WRRO
Lawrence NR, Bacila I, Dawson J, Mahdi S, Alvi S, Cheetham TD, Crowne E, Das U, Dattani MT, Davies JH , Gevers E et al (2023) Quality of Life in Children and Young People With Congenital Adrenal Hyperplasia—UK Nationwide Multicenter Assessment. The Journal of Clinical Endocrinology & Metabolism, 109(1), e336-e346.
Bacila I, Lawrence NR, Mahdi S, Alvi S, Cheetham TD, Crowne E, Das U, Dattani MT, Davies JH, Gevers E , Krone RE et al (2022) Health status of children and young persons with congenital adrenal hyperplasia in the UK (CAH-UK): a cross-sectional multi-centre study. European Journal of Endocrinology, 187(4), 543-553. View this article in WRRO
Lawrence N, Bacila I, Dawson J, Bryce J, Ali SR, van den Akker ELT, Bachega TASS, Baronio F, Birkebæk NH, Bonfig W , Claahsen van der Grinten H et al (2022) Analysis of therapy monitoring in the International Congenital Adrenal Hyperplasia Registry. Clinical Endocrinology, 97(5), 551-561. View this article in WRRO
Bacila I, Cunliffe VT & Krone NP (2021) Interrenal development and function in zebrafish. Molecular and Cellular Endocrinology, 535, 111372-111372.
Bacila I-A, Lawrence N, Mahdi S, Alvi S, Cheetham T, Crowne E, Das U, Dattani M, Davies JH, Gevers EF , Krone R et al (2021) Health Status of Children and Young Persons With Congenital Adrenal Hyperplasia in the United Kingdom: Results of a Multi-Center Cohort Study. Journal of the Endocrine Society, 5(Supplement_1), A717-A717.
Bacila I, Freeman N, Daniel E, Sandrk M, Bryce J, Ali SR, Yavas Abalı Z, Atapattu N, Bachega TA, Balsamo A , Birkebæk N et al (2021) International practice of corticosteroid replacement therapy in congenital adrenal hyperplasia - data from the I-CAH registry. European Journal of Endocrinology, 184(4), 553-563. View this article in WRRO
Bacila I, Adaway J, Hawley J, Mahdi S, Krone R, Patel L, Alvi S, Randell T, Gevers E, Dattani M , Cheetham T et al (2019) Measurement of Salivary Adrenal-Specific Androgens as Biomarkers of Therapy Control in 21-Hydroxylase Deficiency. The Journal of Clinical Endocrinology & Metabolism, 104(12), 6417-6429.
Bacila I-A, Elder C & Krone N (2019) Update on adrenal steroid hormone biosynthesis and clinical implications. Archives of Disease in Childhood, 104(12), 1223-1228. View this article in WRRO
Ferguson GR, Bacila IA & Swamy M (2016) Does current provision of undergraduate education prepare UK medical students in ENT? A systematic literature review. BMJ Open, 6(4), e010054-e010054.
Lawrence NR, Bacila IA, Collins GS, Dawson J, Lang Z-Q, Ji X, Ahmed SF, Alvi S, Bath LE, Blair J , Cheetham T et al () National Service Evaluation of the Quality of Care for Children and Young People with Congenital Adrenal Hyperplasia in the UK: Survey Responses from Patients and Clinicians. Hormone Research in Paediatrics, 1-11.
Balagamage C, Lawrence NR, Krone R, Bacila IA & Krone NP () Blood Pressure in Children with Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency. Hormone Research in Paediatrics, 1-11.

Conference proceedings papers

Oberski L, Bacila I, Cunliffe V & Krone N (2023) The pathophysiologic response of central nervous system due to differently impaired steroidogenesis. HORMONE RESEARCH IN PAEDIATRICS, Vol. 96 (pp 27-28)
Bacila I, Lawrence NR, Ji X, Ahmed SF, Alvi S, Bath L, Blair J, Cheetham T, Crowne L, Davies JH , Dattani M et al (2023) National service evaluation project analysing the quality of care for children and young people with congenital adrenal hyperplasia in the United Kingdom: Data from patients and clinicians. HORMONE RESEARCH IN PAEDIATRICS, Vol. 96 (pp 418-419)
Bacila I, Oberski L, Cunliffe V & Krone N (2023) Metabolic effects of cortisol insufficiency are sex-depended in a zebrafish model of 21-hydroxylase deficiency. HORMONE RESEARCH IN PAEDIATRICS, Vol. 96 (pp 135-135)
Baker EL, Ellis J, Jayes S, Kingsley R, Lee A, Mitchell D, Peakman E, Smith DP, Watts W & Bacila IA (2023) York Paediatric Diabetes Team: A rewarding quality improvement project in children with type 1 diabetes. DIABETIC MEDICINE, Vol. 40
Bacila I, Li N, Eachus H, Storbeck K-H, Cunliffe VT & Krone NP (2022) Towards understanding the metabolic phenotype of glucocorticoid deficiency in 21-hydroxylase deficiency. HORMONE RESEARCH IN PAEDIATRICS, Vol. 95(SUPPL 2) (pp 79-79)
Lawrence NR, Bacila I, Dawson J, Ali SR, van den Akker ELT, Sartori Sanchez Bachega TA, Baronio F, Birkebaek NH, Bonfig W, van der Grinten C , Cools M et al (2022) Blood pressure (BP) status in Congenital Adrenal Hyperplasia (CAH) - longitudinal analysis of real world data from the I-CAH registry. HORMONE RESEARCH IN PAEDIATRICS, Vol. 95(SUPPL 2) (pp 112-113)
Lawrence NR, Bacila I-A, Mahdi S, Albi S, Cheetham TD, Crowne EC, Das U, Dawson J, Dattani MT, Davies J , Gevers E et al (2021) Quality of life in children and young people with congenital adrenal hyperplasia in the United Kingdom - nationwide multicentre assessment. Journal of the Endocrine Society, Vol. 5(Supplement_1) (pp A720-A720). Virtual meeting, 20 March 2021 - 20 March 2021. View this article in WRRO
Bacila I, Lawrence N, Alvi S, Cheetham T, Crowne E, Das U, Dattani M, Davies JH, Gevers E, Krone R , Kyriakou A et al (2021) Re-appraising the use of urinary steroid profiles for assessing therapy control in children with 21-hydroxylase deficiency - results from the CAH-UK cohort study. HORMONE RESEARCH IN PAEDIATRICS, Vol. 94(SUPPL 1) (pp 27-27)
Lawrence N, Bacila I, Dawson J, Bryce J, van den Akker EL, Sartori Sanchez Bachega TA, Baronio F, Birkebaek NH, Bonfig W, Claahsen H , Costa EC et al (2021) Variation of glucocorticoid dose and biomarkers in children with congenital adrenal hyperplasia longitudinal analysis of real world data from the I-CAH registry. HORMONE RESEARCH IN PAEDIATRICS, Vol. 94(SUPPL 1) (pp 26-26)
Lawrence N, Bacila I, Dawson J, Bryce J, van den Akker E, Sartori Sanchez Bachega TA, Baronio F, Birkebaek NH, Bonfig W, Claahsen H , Costa EC et al (2021) International practice of therapy monitoring in congenital adrenal hyperplasia - Real World data from the I-CAH registry. HORMONE RESEARCH IN PAEDIATRICS, Vol. 94(SUPPL 1) (pp 67-68)

Datasets

Bacila I-A Data from: Measurement of salivary adrenal-specific androgens as biomarkers of therapy control in 21-hydroxylase deficiency..