Dr Imran Aziz
MBChB (Honours), MRCP (UK), MRCP (Gastroenterology), MD (Research)
Clinical Medicine, School of Medicine and Population Health
Senior Clinical Lecturer in Gastroenterology
Honorary Consultant Gastroenterologist
Full contact details
Clinical Medicine, School of Medicine and Population Health
The Medical School
Beech Hill Road
Sheffield
S10 2RX
- Profile
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For enquiries please contact - SMPH-West-Operational@sheffield.ac.uk
I qualified in Medicine with Honours in 2004 and undertook training in general medicine and gastroenterology until 2016. During this period, I also completed a postgraduate degree at the University of Sheffield, followed by a two-year post-doctoral fellowship in functional gastrointestinal disorders at the Sahlgrenska Academy, University of Gothenburg, Sweden. In late 2018, I was appointed Senior Clinical Lecturer and Honorary Consultant Gastroenterologist in Sheffield.
I am a Personal Academic Tutor and an Associate Director of Student Affairs for the University of Sheffield MBChB curriculum. I have successfully supervised undergraduate BMedSci and postgraduate research students to thesis/viva completion, including publications of original articles in high-impact journals. In view of my international expertise, I am co-author on the British Society of Gastroenterology guidelines on the management of irritable bowel syndrome and functional dyspepsia. In 2021, I was awarded the United European Gastroenterology Rising Star Award, a prize recognizing promising young clinician scientists across Europe. I serve on the editorial board of Gastroenterology, a leading international journal in the field of GI diseases.
- Research interests
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My research interests are in functional gastrointestinal disorders (e.g. irritable bowel syndrome and functional dyspepsia) and gluten-related disorders.
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- British Society of Gastroenterology guidelines on the management of functional dyspepsia. Gut.
- Disorders of gut‐brain interaction: highly prevalent and burdensome yet under‐taught within medical education. United European Gastroenterology Journal.
- Efficacy and acceptability of dietary therapies in non-constipated irritable bowel syndrome : a randomized trial of traditional dietary advice, the low FODMAP diet and the gluten-free diet. Clinical Gastroenterology and Hepatology. View this article in WRRO
- Functional gastrointestinal disorders and associated health impairment in individuals with celiac disease. Clinical Gastroenterology and Hepatology.
- GREATER OVERLAP OF ROME IV DISORDERS OF GUT-BRAIN INTERACTIONS LEADS TO INCREASED DISEASE SEVERITY AND POORER QUALITY OF LIFE.. Clin Gastroenterol Hepatol.
- The overlap between irritable bowel syndrome and organic gastrointestinal diseases. The Lancet Gastroenterology & Hepatology.
- Diagnostic yield of colonoscopy in patients with symptoms compatible with Rome IV functional bowel disorders. Clinical Gastroenterology and Hepatology.
- High prevalence of primary bile acid diarrhoea in patients with functional diarrhoea and irritable bowel syndrome-diarrhoea, based on Rome III and Rome IV criteria. EClinicalMedicine. View this article in WRRO
- Rome IV functional gastrointestinal disorders and health impairment in subjects with hypermobility spectrum disorders or hypermobile Ehlers-Danlos syndrome. Clinical Gastroenterology and Hepatology. View this article in WRRO
- An approach to the diagnosis and management of Rome IV functional disorders of chronic constipation. Expert Review of Gastroenterology & Hepatology, 14(1), 39-46. View this article in WRRO
- The role of diet in irritable bowel syndrome: implications for dietary advice. Journal of Internal Medicine, 286(5), 490-502.
- Epidemiology, Clinical Characteristics, and Associations for Rome IV Functional Nausea and Vomiting Disorders in Adults. Clinical Gastroenterology and Hepatology, 17(5), 878-886.
- The global phenomenon of self-reported wheat sensitivity. American Journal of Gastroenterology, 113(7), 945-948. View this article in WRRO
- How the Change in IBS Criteria From Rome III to Rome IV Impacts on Clinical Characteristics and Key Pathophysiological Factors. The American Journal of Gastroenterology, 113(7), 1017-1025.
- Epidemiology, clinical characteristics, and associations for symptom-based Rome IV functional dyspepsia in adults in the USA, Canada, and the UK: a cross-sectional population-based study. The Lancet Gastroenterology & Hepatology, 3(4), 252-262.
- The Prevalence and Impact of Overlapping Rome IV-Diagnosed Functional Gastrointestinal Disorders on Somatization, Quality of Life, and Healthcare Utilization: A Cross-Sectional General Population Study in Three Countries. The American Journal of Gastroenterology, 113(1), 86-96.
- The clinical and phenotypical assessment of seronegative villous atrophy; a prospective UK centre experience evaluating 200 adult cases over a 15-year period (2000–2015). Gut, 66, 1563-1572. View this article in WRRO
- Small intestinal bacterial overgrowth as a cause for irritable bowel syndrome. Current Opinion in Gastroenterology, 33(3), 196-202. View this article in WRRO
- Efficacy of a Gluten-Free Diet in Subjects With Irritable Bowel Syndrome-Diarrhea Unaware of Their HLA-DQ2/8 Genotype. Clinical Gastroenterology and Hepatology, 14(5), 696-703.e1.
- High Prevalence of Idiopathic Bile Acid Diarrhea Among Patients With Diarrhea-Predominant Irritable Bowel Syndrome Based on Rome III Criteria. Clinical Gastroenterology and Hepatology, 13(9), 1650-1655.e2.
- The spectrum of noncoeliac gluten sensitivity. Nature Reviews Gastroenterology & Hepatology, 12(9), 516-526.
- A Study Evaluating the Bidirectional Relationship Between Inflammatory Bowel Disease and Self-reported Non-celiac Gluten Sensitivity. Inflammatory Bowel Diseases, 21(4), 847-853.
- A UK study assessing the population prevalence of self-reported gluten sensitivity and referral characteristics to secondary care. European Journal of Gastroenterology & Hepatology, 26(1), 33-39.
- Does gluten sensitivity in the absence of coeliac disease exist?. BMJ, 345(nov30 1), e7907-e7907.
- A Prospective Study of Duodenal Bulb Biopsy in Newly Diagnosed and Established Adult Celiac Disease. American Journal of Gastroenterology, 106(10), 1837-1742.
- A prospective study into the aetiology of lymphocytic duodenosis. Alimentary Pharmacology & Therapeutics, 32(11-12), 1392-1397.
- Increased psychological distress and somatization in patients with irritable bowel syndrome compared with functional diarrhea or functional constipation, based on Rome IV criteria. Neurogastroenterology & Motility.
- British Society of Gastroenterology guidelines on the management of irritable bowel syndrome. Gut.
Chapters
- Small Intestinal Bacterial Overgrowth, Encyclopedia of Gastroenterology (pp. 454-458). Elsevier
- Irritable Bowel Syndrome, Encyclopedia of Gastroenterology (pp. 312-323). Elsevier
All publications
Journal articles
- Faecal immunochemical testing in symptomatic primary care patients: a diagnostic accuracy study. European Journal of Cancer Care, 2024(1). View this article in WRRO
- What is the role of out of programme clinical fellowships in the era of Shape of Training? A single-centre cohort study. BMJ Open Gastroenterology, 11(1), e001311-e001311.
- Dietetic management of irritable bowel syndrome: A national survey of dietary approaches and decision-making factors. Clinical Medicine, 24, 100132-100132.
- Rejection of fecal immunochemical tests within the lower gastrointestinal diagnostic pathway: a cohort study. Journal of Primary Care & Community Health, 15. View this article in WRRO
- Amitriptyline for the management of IBS in primary care. Gastroenterology.
- Does a gluten-free diet improve quality of life and sleep in patients with non-coeliac gluten/wheat sensitivity?. Nutrients, 15(15).
- The national prevalence of disorders of gut brain interaction in the United Kingdom in comparison to their worldwide prevalence: results from the Rome foundation global epidemiology study. Neurogastroenterology & Motility.
- Diagnostic yield of upper gastrointestinal endoscopy in patients attending a UK centre with symptoms compatible with Rome IV functional dyspepsia. Frontline Gastroenterology.
- Diet and irritable bowel syndrome: an update from a UK consensus meeting. BMC Medicine, 20(1).
- Fecal immunochemical testing in patients with low-risk symptoms of colorectal cancer: a diagnostic accuracy study. Journal of the National Comprehensive Cancer Network, 20(9), 989-996.e1.
- British Society of Gastroenterology guidelines on the management of functional dyspepsia. Gut.
- Disorders of gut‐brain interaction: highly prevalent and burdensome yet under‐taught within medical education. United European Gastroenterology Journal.
- This is a response to the letter to the Editor by Staudacher and Gibson, CGH-D-22-01205:. Clinical Gastroenterology and Hepatology.
- Efficacy and acceptability of dietary therapies in non-constipated irritable bowel syndrome : a randomized trial of traditional dietary advice, the low FODMAP diet and the gluten-free diet. Clinical Gastroenterology and Hepatology. View this article in WRRO
- Review article : Physical and psychological comorbidities associated with irritable bowel syndrome. Alimentary Pharmacology & Therapeutics, 54(S1), S12-S23.
- The effects of human milk oligosaccharides on gut microbiota, metabolite profiles and host mucosal response in patients with irritable bowel syndrome. Nutrients, 13(11).
- Health care utilization of individuals with Rome IV irritable bowel syndrome in the general population. United European Gastroenterology Journal.
- NCGS like IBS ‘type’ symptoms is a diagnosis of exclusion. Nutrition Journal, 20(1). View this article in WRRO
- Functional gastrointestinal disorders and associated health impairment in individuals with celiac disease. Clinical Gastroenterology and Hepatology.
- The low FODMAP diet for IBS; A multicentre UK study assessing long term follow up.. Dig Liver Dis.
- GREATER OVERLAP OF ROME IV DISORDERS OF GUT-BRAIN INTERACTIONS LEADS TO INCREASED DISEASE SEVERITY AND POORER QUALITY OF LIFE.. Clin Gastroenterol Hepatol.
- The overlap between irritable bowel syndrome and organic gastrointestinal diseases. The Lancet Gastroenterology & Hepatology.
- Personalising dietary therapies for irritable bowel syndrome – what is gluten’s role. Clinical Gastroenterology and Hepatology.
- Diagnostic yield of colonoscopy in patients with symptoms compatible with Rome IV functional bowel disorders. Clinical Gastroenterology and Hepatology.
- Functional gastrointestinal disorders are increased in joint hypermobility-related disorders with concomitant postural orthostatic tachycardia syndrome.. Neurogastroenterology and Motility.
- High prevalence of primary bile acid diarrhoea in patients with functional diarrhoea and irritable bowel syndrome-diarrhoea, based on Rome III and Rome IV criteria. EClinicalMedicine. View this article in WRRO
- Clinical phenotype and mortality in patients with idiopathic small bowel villous atrophy: a dual-centre international study. European Journal of Gastroenterology & Hepatology. View this article in WRRO
- The diagnostic value of a change in bowel habit for colorectal cancer within different age groups. United European Gastroenterology Journal, 8(2), 211-219.
- Rome IV functional gastrointestinal disorders and health impairment in subjects with hypermobility spectrum disorders or hypermobile Ehlers-Danlos syndrome. Clinical Gastroenterology and Hepatology. View this article in WRRO
- Evidence of altered mucosa-associated and fecal microbiota composition in patients with irritable bowel syndrome. Scientific Reports, 10(1). View this article in WRRO
- The use of small-bowel capsule endoscopy in cases of equivocal celiac disease. Gastrointestinal Endoscopy. View this article in WRRO
- A gluten reduction is the patients’ choice for a dietary ‘bottom up’ approach in IBS—a comment on “a 5Ad dietary protocol for functional bowel disorders” nutrients 2019, 11, 1938. Nutrients, 12(1). View this article in WRRO
- An approach to the diagnosis and management of Rome IV functional disorders of chronic constipation. Expert Review of Gastroenterology & Hepatology, 14(1), 39-46. View this article in WRRO
- Letter: the gluten-free diet as a bottom-up approach for irritable bowel syndrome. Alimentary Pharmacology & Therapeutics, 51(1), 184-185.
- The role of diet in irritable bowel syndrome: implications for dietary advice. Journal of Internal Medicine, 286(5), 490-502.
- A Gluten-Free Diet. The American Journal of Gastroenterology, 114(9), 1553-1553.
- How patients with IBS use low FODMAP dietary information provided by general practitioners and gastroenterologists : a qualitative study. Nutrients, 11(6). View this article in WRRO
- View this article in WRRO A population survey of dietary attitudes towards gluten. Nutrients, 11(6).
- Epidemiology, Clinical Characteristics, and Associations for Rome IV Functional Nausea and Vomiting Disorders in Adults. Clinical Gastroenterology and Hepatology, 17(5), 878-886.
- Letter: the low FODMAP diet is not the only diet for IBS. Alimentary Pharmacology & Therapeutics, 49(8), 1108-1109.
- Breaking bread!. Proceedings of the Nutrition Society, 78(1), 118-125.
- The global phenomenon of self-reported wheat sensitivity. American Journal of Gastroenterology, 113(7), 945-948. View this article in WRRO
- How the Change in IBS Criteria From Rome III to Rome IV Impacts on Clinical Characteristics and Key Pathophysiological Factors. The American Journal of Gastroenterology, 113(7), 1017-1025.
- Epidemiology, clinical characteristics, and associations for symptom-based Rome IV functional dyspepsia in adults in the USA, Canada, and the UK: a cross-sectional population-based study. The Lancet Gastroenterology & Hepatology, 3(4), 252-262.
- The Prevalence and Impact of Overlapping Rome IV-Diagnosed Functional Gastrointestinal Disorders on Somatization, Quality of Life, and Healthcare Utilization: A Cross-Sectional General Population Study in Three Countries. The American Journal of Gastroenterology, 113(1), 86-96.
- The clinical and phenotypical assessment of seronegative villous atrophy; a prospective UK centre experience evaluating 200 adult cases over a 15-year period (2000–2015). Gut, 66, 1563-1572. View this article in WRRO
- Small intestinal bacterial overgrowth as a cause for irritable bowel syndrome. Current Opinion in Gastroenterology, 33(3), 196-202. View this article in WRRO
- Is there a relationship between gluten sensitivity and postural tachycardia syndrome?. European Journal of Gastroenterology & Hepatology, 28(12), 1383-1387.
- Letter: gluten challenge in the era of noncoeliac gluten sensitivity - a change in clinical practice?. Alimentary Pharmacology & Therapeutics, 43(5), 656-656.
- From coeliac disease to noncoeliac gluten sensitivity; should everyone be gluten free?. Current Opinion in Gastroenterology, 32(2), 120-127.
- Efficacy of a Gluten-Free Diet in Subjects With Irritable Bowel Syndrome-Diarrhea Unaware of Their HLA-DQ2/8 Genotype. Clinical Gastroenterology and Hepatology, 14(5), 696-703.e1.
- High Prevalence of Idiopathic Bile Acid Diarrhea Among Patients With Diarrhea-Predominant Irritable Bowel Syndrome Based on Rome III Criteria. Clinical Gastroenterology and Hepatology, 13(9), 1650-1655.e2.
- Noncoeliac gluten sensitivity. Current Opinion in Clinical Nutrition and Metabolic Care, 18(5), 508-514.
- The spectrum of noncoeliac gluten sensitivity. Nature Reviews Gastroenterology & Hepatology, 12(9), 516-526.
- A Study Evaluating the Bidirectional Relationship Between Inflammatory Bowel Disease and Self-reported Non-celiac Gluten Sensitivity. Inflammatory Bowel Diseases, 21(4), 847-853.
- The rise and fall of gluten!. Proceedings of the Nutrition Society, 74(3), 221-226.
- Screening for bile acid diarrhoea in suspected irritable bowel syndrome. Gut, 64(5), 851.1-851.
- Self-Reported Gluten Sensitivity: An International Concept in Need of Consensus?. American Journal of Gastroenterology, 109(9), 1498-1499.
- Change in awareness of gluten-related disorders among chefs and the general public in the UK. European Journal of Gastroenterology & Hepatology, 26(11), 1228-1233.
- Prevalence, investigational pathways and diagnostic outcomes in differing irritable bowel syndrome subtypes. European Journal of Gastroenterology & Hepatology, 26(10), 1176-1180.
- Predictors for Celiac Disease in Adult Cases of Duodenal Intraepithelial Lymphocytosis. Journal of Clinical Gastroenterology, 1-1.
- Editorial: noncoeliac gluten sensitivity - a disease of the mind or gut?. Alimentary Pharmacology & Therapeutics, 40(1), 113-114.
- Noncoeliac gluten sensitivity—food for thought. Nature Reviews Gastroenterology & Hepatology, 11(7), 398-399.
- Patients Who Avoid Wheat and Gluten: Is That Health or Lifestyle?. Digestive Diseases and Sciences, 59(6), 1080-1082.
- A UK study assessing the population prevalence of self-reported gluten sensitivity and referral characteristics to secondary care. European Journal of Gastroenterology & Hepatology, 26(1), 33-39.
- Non-celiac gluten sensitivity: clinical relevance and recommendations for future research. Neurogastroenterology & Motility, 25(11), 864-871.
- Quality not quantity for transglutaminase antibody 2: the performance of an endomysial and tissue transglutaminase test in screening coeliac disease remains stable over time. Clinical & Experimental Immunology, 171(1), 100-106.
- Capsule endoscopy in adult celiac disease: a potential role in equivocal cases of celiac disease?. Gastrointestinal Endoscopy, 77(2), 227-232.
- Editorial: Non-Celiac Wheat Sensitivity: Separating the Wheat from the Chat!. American Journal of Gastroenterology, 107(12), 1908-1912.
- The Irritable Bowel Syndrome-Celiac Disease Connection. Gastrointestinal Endoscopy Clinics of North America, 22(4), 623-637.
- Emerging concepts: from coeliac disease to non-coeliac gluten sensitivity. Proceedings of the Nutrition Society, 71(4), 576-580.
- Are we diagnosing too many people with coeliac disease?. Proceedings of the Nutrition Society, 71(4), 538-544.
- Does gluten sensitivity in the absence of coeliac disease exist?. BMJ, 345(nov30 1), e7907-e7907.
- A Prospective Study of Duodenal Bulb Biopsy in Newly Diagnosed and Established Adult Celiac Disease. American Journal of Gastroenterology, 106(10), 1837-1742.
- Are patients with coeliac disease seeking alternative therapies to a gluten-free diet?. J Gastrointestin Liver Dis, 20(1), 27-31.
- A prospective study into the aetiology of lymphocytic duodenosis. Alimentary Pharmacology & Therapeutics, 32(11-12), 1392-1397.
- A machine learning approach to stratify patients with hypermobile Ehlers‐Danlos syndrome/hypermobility spectrum disorders according to disorders of gut brain interaction, comorbidities and quality of life. Neurogastroenterology & Motility.
- Dietetic Management of Irritable Bowel Syndrome: A National Survey of Dietary Approaches and Decision-making Factors. Journal of Gastrointestinal and Liver Diseases, 33(2), 177-183.
- Prevalence and Burden of Disorders of Gut-Brain Interaction Among UK Medical Students. International Journal of Medical Students, 12(1), 43-52.
- Mast cell activation and nutritional disorders in patients with hypermobility. Current Opinion in Gastroenterology.
- Randomized trial in postprandial functional dyspepsia: Reassurance and diagnostic explanation with or without traditional dietary advice. Neurogastroenterology & Motility.
- Further research needed to determine first-line therapy for IBS in primary care. Gut.
- Clinical classification and long‐term outcomes of seronegative coeliac disease: a 20‐year multicentre follow‐up study. Alimentary Pharmacology & Therapeutics.
- Prioritisation of lower gastrointestinal endoscopy during the COVID-19 pandemic: outcomes of a novel triage pathway. Frontline Gastroenterology.
- What is the optimal FODMAP threshold in IBS?. Journal of Gastroenterology and Hepatology.
- Increased psychological distress and somatization in patients with irritable bowel syndrome compared with functional diarrhea or functional constipation, based on Rome IV criteria. Neurogastroenterology & Motility.
- Coeliac disease and noncoeliac wheat or gluten sensitivity. Journal of Internal Medicine.
- National survey evaluating the provision of gastroenterology dietetic services in England. Frontline Gastroenterology.
- Is CBT the dominant non-drug IBS treatment? The rise of dietary therapies. Gut.
- Brain fog and non-coeliac gluten sensitivity: Proof of concept brain MRI pilot study. PLOS ONE, 15(8), e0238283-e0238283.
- Human milk oligosaccharide supplementation in irritable bowel syndrome patients: A parallel, randomized, double‐blind, placebo‐controlled study. Neurogastroenterology & Motility.
- British Society of Gastroenterology guidelines on the management of irritable bowel syndrome. Gut.
Chapters
- Small Intestinal Bacterial Overgrowth, Encyclopedia of Gastroenterology (pp. 454-458). Elsevier
- Irritable Bowel Syndrome, Encyclopedia of Gastroenterology (pp. 312-323). Elsevier
- Coeliac disease and nutrition, ADVANCED NUTRITION AND DIETETICS IN GASTROENTEROLOGY (pp. 160-168).
- Teaching interests
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My teaching and other lecture duties cover clinical gastroenterology on both the MBChB and BDS course. I also provide postgraduate teaching to both junior doctors and allied healthcare professionals.