Dr Hugo Penny
MBBS, MRCP, PhD.
Clinical Medicine, School of Medicine and Population Health
NIHR Clinical Lecturer in Gastroenterology
+44 114 271 2271
Full contact details
Clinical Medicine, School of Medicine and Population Health
Royal Hallamshire Hospital
Glossop Road
Sheffield
S10 2JF
- Profile
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For enquiries please contact - SMPH-West-Operational@sheffield.ac.uk
I completed my undergraduate medical training at King’s College London in 2012, after which I moved to Sheffield for foundation training, and subsequently completed an Academic Clinical Fellowship alongside core medical training in South Yorkshire. I moved to Manchester to undertake a Wellcome Trust PhD Fellowship in Immunology in the lab of Dr Matthew Hepworth (University of Manchester) and then returned to Sheffield to complete my specialist training in Gastroenterology. In 2021 I was awarded an NIHR Academic Clinical Lectureship at the University of Sheffield to undertake research alongside my clinical training. My research focuses on clinical and translational aspects of small bowel diseases such as coeliac disease and other chronic enteropathies.
- Qualifications
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- MBBS, King’s College London, 2012
- PhD, University of Manchester, 2020
- MRCP(UK), (Gastroenterology), Royal College of Physicians
- Research interests
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My research interests are focused on clinical and translational aspects of diseases of the small bowel including coeliac disease, and other chronic enteropathies. I am also interested in fundamental and mechanistic immunology of the GI tract, including the cross-talk between the immune system and commensal microbiota.
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- Rhythmicity of intestinal IgA responses confers oscillatory commensal microbiota mutualism. Science Immunology, 7(75).
- Accuracy of a no-biopsy approach for the diagnosis of coeliac disease across different adult cohorts. Gut, 70(5), 876-883. View this article in WRRO
- Non-responsive coeliac disease : a comprehensive review from the NHS England national centre for refractory coeliac disease. Nutrients, 12(1). View this article in WRRO
Chapters
- The Role of Endoscopy in Refractory Coeliac Disease, Refractory Celiac Disease (pp. 51-62). Springer International Publishing
All publications
Journal articles
- Clinical outcomes of potential coeliac disease: a systematic review and meta-analysis. Gut, gutjnl-2024.
- Role of capsule endoscopy and double-balloon enteroscopy in the management of adult patients with coeliac disease and persisting symptoms. Digestive and Liver Disease.
- Narrow-band imaging for optical diagnosis of duodenal villous atrophy in patients with suspected coeliac disease: A systematic review and meta-analysis. Digestive and Liver Disease.
- Current evidence for dietary therapies in irritable bowel syndrome. Current Opinion in Gastroenterology, 39(3), 219-226.
- The debate in the diagnosis of coeliac disease – time to go ‘no-biopsy’?. Current Opinion in Gastroenterology, 39(3), 192-199.
- Rhythmicity of intestinal IgA responses confers oscillatory commensal microbiota mutualism. Science Immunology, 7(75).
- Non-responsive and refractory coeliac disease : experience from the NHS England National Centre. Nutrients, 14(13). View this article in WRRO
- Do gastroenterologists have medical inertia towards coeliac disease? A UK multicentre secondary care study. BMJ Open Gastroenterology, 8(1). View this article in WRRO
- Accuracy of a no-biopsy approach for the diagnosis of coeliac disease across different adult cohorts. Gut, 70(5), 876-883. View this article in WRRO
- Progress in the serology-based diagnosis and management of adult celiac disease. Expert Review of Gastroenterology & Hepatology, 14(3), 147-154.
- Non-responsive coeliac disease : a comprehensive review from the NHS England national centre for refractory coeliac disease. Nutrients, 12(1). View this article in WRRO
- How to manage adult coeliac disease: perspective from the NHS England Rare Diseases Collaborative Network for Non-Responsive and Refractory Coeliac Disease. Frontline Gastroenterology, 11(3), 235-242.
- Healthcare professionals' attitudes towards PEG tube feeding in advanced dementia: time to engage with a wide clinical audience?. Minerva Gastroenterologica e Dietologica, 65(3).
- First UK data for CT angiography in persisting upper GI bleeding. Frontline Gastroenterology, 9(4), 331-332. View this article in WRRO
- Orchestration of intestinal homeostasis and tolerance by group 3 innate lymphoid cells. Seminars in Immunopathology, 40(4), 357-370.
- Is there a relationship between gluten sensitivity and postural tachycardia syndrome?. European Journal of Gastroenterology & Hepatology, 28(12), 1383-1387.
- High definition endoscopy with or without I-Scan increases the detection of celiac disease during routine endoscopy. Digestive and Liver Disease, 48(6), 644-649.
- Changing trends in the UK management of upper GI bleeding: is there evidence of reduced UK training experience?. Frontline Gastroenterology, 7(1), 67-72.
- View this article in WRRO The relationship between inflammatory bowel disease and type 1 diabetes mellitus: a study of relative prevalence in comparison with population controls. Journal of Gastrointestinal and Liver Diseases, 24(1), 125-126.
- Impact of direct drug delivery via gastric access devices. Expert Opinion on Drug Delivery, 12(3), 455-463.
- Vitamin D in Renal Transplantation – from Biological Mechanisms to Clinical Benefits. American Journal of Transplantation, 14(6), 1259-1270.
- The Janus faces of ESAs: caveat Chimaera!. International Urology and Nephrology, 45(3), 761-767.
- How Well Do Renal Transplant Patients “Cover-Up”? Seasonal Vitamin D Variation in Long-Term Renal Transplant Survivors. Transplantation Journal, 94(10S), 877-878.
- Determinants of vitamin
D status in long‐term renal transplant patients. Clinical Transplantation, 26(6). - Vascular and Arterial Calcification in Peritoneal Dialysis Patients – State-of-the-Art 2012, 189-194.
- Optimising the Diagnosis of Adult Coeliac Disease: Current Evidence and Future Directions. British Journal of Hospital Medicine, 1-21.
- Is There a Need to Undertake Conventional Gastroscopy and Biopsy When Making the Diagnosis of Coeliac Disease in Adults?. Journal of Clinical Gastroenterology, 57(2), 139-142.
- Coeliac Disease and Probiotics: Clinicians Need to Provide the Evidence Base for this Unmet Need. Journal of Gastrointestinal and Liver Diseases, 30(4), 423-426.
- Impact of seasonality on the dynamics of native Vitamin D repletion in long-term renal transplant patients. Clinical Kidney Journal, sfw136-sfw136.
Chapters
- Immune Responses at Host Barriers and Their Importance in Systemic Autoimmune Diseases, Advances in Experimental Medicine and Biology (pp. 3-24). Springer Nature Switzerland
- The Role of Endoscopy in Refractory Coeliac Disease, Refractory Celiac Disease (pp. 51-62). Springer International Publishing
- Nonresponsive and complicated coeliac disease, Coeliac Disease and Gluten-Related Disorders (pp. 87-100). Elsevier
Preprints