Dr Helen Marriott

PhD

Clinical Medicine, School of Medicine and Population Health

Lecturer in Respiratory Infection

h.m.marriott@sheffield.ac.uk
+44 114 215 9537

+44 114 271 1863 (fax)

The Medical School

Full contact details

Dr Helen Marriott
Clinical Medicine, School of Medicine and Population Health
The Medical School
Beech Hill Road
Sheffield
S10 2RX

Profile

For enquiries please contact - ClinMed-Operational@sheffield.ac.uk

I joined the University of Sheffield in 1995 from the Department of Respiratory Physiology, Papworth Hospital, Cambridge. From 1995 to 2001 my research was on the pulmonary circulation, focusing on animal models of pulmonary hypertension. This formed the basis of my PhD, "Pulmonary hypertension: susceptibility and treatment in rat models".

In 2001 I joined Professor David Dockrell´s group as a post-doctoral research associate investigating the role of macrophage apoptosis in pneumococcal infection.

In 2005 I was awarded an independent fellowship from the British Lung Foundation to investigate the effects of influenza A virus on macrophage innate immune function.

In 2015 I was appointed Lecturer in Respiratory Infection.

Since 2016 I have been the academic lead of the Medical School Flow Cytometry Core Facility.

Research interests

My main research interest is in the role of macrophages in host defense against respiratory pathogens, in particular Streptococcus pneumoniae. I am also interested in the effect of influenza A virus on macrophage function, its effect on the regulation of macrophage apoptosis and how this may lead to increased susceptibility to bacterial superinfections. I have been using a variety of in vitro, in vivo models and computational models to support this research.

Current projects

Re-engaging antimicrobial killing by macrophages to combat antimicrobial resistance.

I was awarded an Innovation grant from the MRC as part of the cross research council initiative Tackling Antimicrobial Resistance to identify new targets for novel antibacterials. We have described macrophage apoptosis associated killing as an alternative means by which macrophages kill bacteria, however we have found that this is subverted in some patients at increased risk of bacterial infections, such as Chronic Obstructive Lung Disease. In addition some bacteria, notably S. aureus, can prevent macrophage apoptosis associated killing to survive within macrophages. In this grant we will screen and develop compounds to engage macrophage apoptosis as a means to improve bacterial killing and modify inflammation. By targeting the host, rather than the pathogen, we anticipate this will avoid antimicrobial resistance. This concept is a focus of the MRC Collaborative Grant, Optimising Innate Host Defence to Combat Antimicrobial Resistance of which I am a co-investigator.

Molecular analysis of the effects of influenza A virus on macrophage innate immune function (Wellcome Trust VIP award and Personal fellowship from the British Lung Foundation).

The aim of my fellowship was to characterise the effect of influenza A virus on macrophage function, with particular emphasis on its effect on the regulation of macrophage apoptosis. I have established in vitro macrophage and in vivo murine models of IAV infection and shown that both human monocyte derived macrophages and murine macrophages undergo apoptosis after influenza A virus infection. I am investigating how this relates to cytokine production, generation of antimicrobial molecules and killing of bacteria.

Role of ubiquitination in regulation of macrophage viability after bacterial infection.

Macrophages do not undergo apoptosis after infection with S. aureus or N. meningitidis, and I have shown this is associated with an increase in the anti-apoptotic protein Mcl-1. I am currently investigating the mechanism behind this up-regulation focusing on the role of post-translational modifications, in particular ubiquitination, and identifying the bacterial factors responsible.

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Marsh EK, Prestwich EC, Williams L, Hart AR, Muir CF, Parker LC, Jonker MR, Heijink IH, Timens W, Fife M , Hussell T et al (2020) Pellino-1 regulates the responses of the airway to viral infection. Frontiers in Cellular and Infection Microbiology, 10.
Best A, Jubrail J, Boots M, Dockrell D & Marriott H (2020) A mathematical model shows macrophages delay staphylococcus aureus replication, but limitations in microbicidal capacity restrict bacterial clearance. Journal of Theoretical Biology, 497. View this article in WRRO
Preston JA, Bewley MA, Marriott HM, Houghton AM, Mohasin M, Jubrail J, Morris L, Stephenson YL, Cross S, Greaves DR , Craig RW et al (2019) Alveolar Macrophage Apoptosis-Associated Bacterial Killing Helps Prevent Murine Pneumonia.. American Journal of Respiratory and Critical Care Medicine. View this article in WRRO
Collini PJ, Bewley MA, Mohasin M, Marriott HM, Miller RF, Geretti AM, Beloukas A, Papadimitropoulos A, Read RC, Noursadeghi M & Dockrell D (2018) HIV gp120 in the Lungs of Antiretroviral Therapy–treated Individuals Impairs Alveolar Macrophage Responses to Pneumococci. American Journal of Respiratory and Critical Care Medicine, 197(12). View this article in WRRO
Bewley MA, Preston JA, Mohasin M, Marriott HM, Budd RC, Swales J, Collini P, Greaves DR, Craig RW, Brightling CE , Donnelly LE et al (2017) Impaired Mitochondrial Microbicidal Responses in Chronic Obstructive Pulmonary Disease Macrophages.. American Journal of Respiratory and Critical Care Medicine, 196(7), 845-855. View this article in WRRO
Thompson AAR, Dickinson RS, Murphy F, Thomson JP, Marriott HM, Tavares A, Willson J, Williams L, Lewis A, Mirchandani A , Coelho PDS et al (2017) Hypoxia determines survival outcomes of bacterial infection through HIF-1α-dependent reprogramming of leukocyte metabolism. Science Immunology, 2(8). View this article in WRRO
Jubrail J, Morris P, Bewley MA, Stoneham S, Johnston SA, Foster SJ, Peden AA, Read RC, Marriott HM & Dockrell DH (2015) Inability to sustain intraphagolysosomal killing of Staphylococcus aureus predisposes to bacterial persistence in macrophages. Cellular Microbiology, 18(1), 80-96. View this article in WRRO
Bewley MA, Naughton M, Preston J, Mitchell A, Holmes A, Marriott HM, Read RC, Mitchell TJ, Whyte MKB & Dockrell DH (2014) Pneumolysin Activates Macrophage Lysosomal Membrane Permeabilization and Executes Apoptosis by Distinct Mechanisms without Membrane Pore Formation. mBio, 5(5). View this article in WRRO
Thompson AAR, Elks PM, Marriott HM, Eamsamarng S, Higgins KR, Lewis A, Williams L, Parmar S, Shaw G, McGrath EE , Formenti F et al (2013) Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice and zebrafish. Blood, 123(3), 366-376.
Marriott HM, Daigneault M, Thompson AAR, Walmsley SR, Gill SK, Witcher DR, Wroblewski VJ, Hellewell PG, Whyte MKB & Dockrell DH (2012) A decoy receptor 3 analogue reduces localised defects in phagocyte function in pneumococcal pneumonia.. Thorax, 67(11), 985-992. View this article in WRRO
Daigneault M, de Silva TI, Bewley MA, Preston JA, Marriott HM, Mitchell AM, Mitchell TJ, Read RC, Whyte MKB & Dockrell DH (2012) Monocytes regulate the mechanism of T-cell death by inducing Fas-mediated apoptosis during bacterial infection. PLoS Pathogens, 8(7), 30. View this article in WRRO
McGrath EE, Lawrie A, Marriott HM, Mercer P, Cross SS, Arnold N, Singleton V, Thompson AAR, Walmsley SR, Renshaw SA , Sabroe I et al (2012) Deficiency of tumour necrosis factor-related apoptosis-inducing ligand exacerbates lung injury and fibrosis.. Thorax, 67(9), 796-803. View this article in WRRO
Marriott HM, Gascoyne KA, Gowda R, Geary I, Nicklin MJH, Iannelli F, Pozzi G, Mitchell TJ, Whyte MKB, Sabroe I & Dockrell DH (2012) Interleukin-1β regulates CXCL8 release and influences disease outcome in response to Streptococcus pneumoniae, defining intercellular cooperation between pulmonary epithelial cells and macrophages.. Infect Immun, 80(3), 1140-1149. View this article in WRRO
McGrath EE, Marriott HM, Lawrie A, Francis SE, Sabroe I, Renshaw SA, Dockrell DH & Whyte MKB (2011) TNF-related apoptosis-inducing ligand (TRAIL) regulates inflammatory neutrophil apoptosis and enhances resolution of inflammation.. J Leukoc Biol, 90(5), 855-865. View this article in WRRO
Bewley MA, Pham TK, Marriott HM, Noirel J, Chu H-P, Ow SY, Ryazanov AG, Read RC, Whyte MKB, Chain B , Wright PC et al (2011) Proteomic evaluation and validation of cathepsin D regulated proteins in macrophages exposed to Streptococcus pneumoniae.. Mol Cell Proteomics, 10(6), M111.008193. View this article in WRRO
Walmsley SR, Chilvers ER, Thompson AA, Vaughan K, Marriott HM, Parker LC, Shaw G, Parmar S, Schneider M, Sabroe I , Dockrell DH et al (2011) Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice.. J Clin Invest, 121(3), 1053-1063. View this article in WRRO
Bewley MA, Marriott HM, Tulone C, Francis SE, Mitchell TJ, Read RC, Chain B, Kroemer G, Whyte MKB & Dockrell DH (2011) A cardinal role for cathepsin d in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci.. PLoS Pathog, 7(1), e1001262. View this article in WRRO
Webster SJ, Daigneault M, Bewley MA, Preston JA, Marriott HM, Walmsley SR, Read RC, Whyte MKB & Dockrell DH (2010) Distinct cell death programs in monocytes regulate innate responses following challenge with common causes of invasive bacterial disease.. J Immunol, 185(5), 2968-2979.
Daigneault M, Preston JA, Marriott HM, Whyte MK & Dockrell DH (2010) The identification of markers of macrophage differentiation in PMA-stimulated THP-1 cells and monocyte-derived macrophages.. PLoS One, 5(1), e8668. View this article in WRRO
Marriott HM, Jackson LE, Wilkinson TS, Simpson AJ, Mitchell TJ, Buttle DJ, Cross SS, Ince PG, Hellewell PG, Whyte MKB & Dockrell DH (2008) Reactive oxygen species regulate neutrophil recruitment and survival in pneumococcal pneumonia.. Am J Respir Crit Care Med, 177(8), 887-895. View this article in WRRO
Marriott HM, Hellewell PG, Cross SS, Ince PG, Whyte MKB & Dockrell DH (2006) Decreased alveolar macrophage apoptosis is associated with increased pulmonary inflammation in a murine model of pneumococcal pneumonia.. J Immunol, 177(9), 6480-6488. View this article in WRRO
Tunbridge AJ, Stevanin TM, Lee M, Marriott HM, Moir JWB, Read RC & Dockrell DH (2006) Inhibition of macrophage apoptosis by Neisseria meningitidis requires nitric oxide detoxification mechanisms.. Infect Immun, 74(1), 729-733.
Marriott HM, Bingle CD, Read RC, Braley KE, Kroemer G, Hellewell PG, Craig RW, Whyte MKB & Dockrell DH (2005) Dynamic changes in Mcl-1 expression regulate macrophage viability or commitment to apoptosis during bacterial clearance. J CLIN INVEST, 115(2), 359-368. View this article in WRRO
Marriott HM, Ali F, Read RC, Mitchell TJ, Whyte MKB & Dockrell DH (2004) Nitric oxide levels regulate macrophage commitment to apoptosis or necrosis during pneumococcal infection.. FASEB J, 18(10), 1126-1128. View this article in WRRO
Dockrell DH, Marriott HM, Prince LR, Ridger VC, Ince PG, Hellewell PG & Whyte MKB (2003) Alveolar macrophage apoptosis contributes to pneumococcal clearance in a resolving model of pulmonary infection.. J Immunol, 171(10), 5380-5388. View this article in WRRO

All publications

Journal articles

Marsh EK, Prestwich EC, Williams L, Hart AR, Muir CF, Parker LC, Jonker MR, Heijink IH, Timens W, Fife M , Hussell T et al (2020) Pellino-1 regulates the responses of the airway to viral infection. Frontiers in Cellular and Infection Microbiology, 10.
Best A, Jubrail J, Boots M, Dockrell D & Marriott H (2020) A mathematical model shows macrophages delay staphylococcus aureus replication, but limitations in microbicidal capacity restrict bacterial clearance. Journal of Theoretical Biology, 497. View this article in WRRO
Fenaroli F, Robertson JD, Scarpa E, Gouveia VM, Di Guglielmo C, De Pace C, Elks PM, Poma A, Evangelopoulos D, Canseco JO , Prajsnar TK et al (2020) Polymersomes eradicating intracellular bacteria. ACS Nano. View this article in WRRO
Hughes BM, Burton CS, Reese A, Jabeen MF, Wright C, Willis J, Khoshaein N, Marsh EK, Peachell P, Sun SC , Dockrell DH et al (2019) Pellino-1 regulates immune responses to Haemophilus influenzae in models of inflammatory lung disease. Frontiers in Immunology, 10. View this article in WRRO
Preston JA, Bewley MA, Marriott HM, Houghton AM, Mohasin M, Jubrail J, Morris L, Stephenson YL, Cross S, Greaves DR , Craig RW et al (2019) Alveolar Macrophage Apoptosis-Associated Bacterial Killing Helps Prevent Murine Pneumonia.. American Journal of Respiratory and Critical Care Medicine. View this article in WRRO
Braithwaite AT, Marriott H & Lawrie A (2018) Divergent Roles for TRAIL in Lung Diseases. Frontiers in Medicine, 5. View this article in WRRO
Collini PJ, Bewley MA, Mohasin M, Marriott HM, Miller RF, Geretti AM, Beloukas A, Papadimitropoulos A, Read RC, Noursadeghi M & Dockrell D (2018) HIV gp120 in the Lungs of Antiretroviral Therapy–treated Individuals Impairs Alveolar Macrophage Responses to Pneumococci. American Journal of Respiratory and Critical Care Medicine, 197(12). View this article in WRRO
Bewley MA, Preston JA, Mohasin M, Marriott HM, Budd RC, Swales J, Collini P, Greaves DR, Craig RW, Brightling CE , Donnelly LE et al (2017) Impaired Mitochondrial Microbicidal Responses in Chronic Obstructive Pulmonary Disease Macrophages.. American Journal of Respiratory and Critical Care Medicine, 196(7), 845-855. View this article in WRRO
Sadiku P, Willson JA, Dickinson RS, Murphy F, Harris AJ, Lewis A, Sammut D, Mirchandani AS, Ryan E, Watts ER , Thompson AAR et al (2017) Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses.. Journal of Clinical Investigation, 127(9), 3407-3420. View this article in WRRO
Thompson AAR, Dickinson RS, Murphy F, Thomson JP, Marriott HM, Tavares A, Willson J, Williams L, Lewis A, Mirchandani A , Coelho PDS et al (2017) Hypoxia determines survival outcomes of bacterial infection through HIF-1α-dependent reprogramming of leukocyte metabolism. Science Immunology, 2(8). View this article in WRRO
Gill SK, Marriott HM, Suvarna SK & Peachell PT (2016) Evaluation of the anti-inflammatory effects of β-adrenoceptor agonists on human lung macrophages. European Journal of Pharmacology, 793, 49-55. View this article in WRRO
Gill SK, Yao Y, Kay LJ, Bewley MA, Marriott HM & Peachell PT (2016) The anti-inflammatory effects of prostaglandin E 2 on human lung macrophages are mediated by the EP 4 receptor. British Journal of Pharmacology, 173(21), 3099-3109. View this article in WRRO
Jubrail J, Morris P, Bewley MA, Stoneham S, Johnston SA, Foster SJ, Peden AA, Read RC, Marriott HM & Dockrell DH (2015) Inability to sustain intraphagolysosomal killing of Staphylococcus aureus predisposes to bacterial persistence in macrophages. Cellular Microbiology, 18(1), 80-96. View this article in WRRO
Bewley MA, Naughton M, Preston J, Mitchell A, Holmes A, Marriott HM, Read RC, Mitchell TJ, Whyte MKB & Dockrell DH (2014) Pneumolysin Activates Macrophage Lysosomal Membrane Permeabilization and Executes Apoptosis by Distinct Mechanisms without Membrane Pore Formation. mBio, 5(5). View this article in WRRO
Aberdein JD, Cole J, Bewley MA, Marriott HM & Dockrell DH (2013) Alveolar macrophages in pulmonary host defence the unrecognized role of apoptosis as a mechanism of intracellular bacterial killing.. Clin Exp Immunol, 174(2), 193-202.
Thompson AAR, Elks PM, Marriott HM, Eamsamarng S, Higgins KR, Lewis A, Williams L, Parmar S, Shaw G, McGrath EE , Formenti F et al (2013) Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice and zebrafish. Blood, 123(3), 366-376.
Bazaz R, Marriott HM, Francis SE & Dockrell DH (2013) Mechanistic links between acute respiratory tract infections and acute coronary syndromes.. J Infect, 66(1), 1-17.
Musa M, Wilson K, Sun L, Mulay A, Bingle L, Marriott HM, LeClair EE & Bingle CD (2012) Differential localisation of BPIFA1 (SPLUNC1) and BPIFB1 (LPLUNC1) in the nasal and oral cavities of mice.. Cell Tissue Res, 350(3), 455-464. View this article in WRRO
Marriott HM, Daigneault M, Thompson AAR, Walmsley SR, Gill SK, Witcher DR, Wroblewski VJ, Hellewell PG, Whyte MKB & Dockrell DH (2012) A decoy receptor 3 analogue reduces localised defects in phagocyte function in pneumococcal pneumonia.. Thorax, 67(11), 985-992. View this article in WRRO
Daigneault M, de Silva TI, Bewley MA, Preston JA, Marriott HM, Mitchell AM, Mitchell TJ, Read RC, Whyte MKB & Dockrell DH (2012) Monocytes regulate the mechanism of T-cell death by inducing Fas-mediated apoptosis during bacterial infection. PLoS Pathogens, 8(7), 30. View this article in WRRO
McGrath EE, Lawrie A, Marriott HM, Mercer P, Cross SS, Arnold N, Singleton V, Thompson AAR, Walmsley SR, Renshaw SA , Sabroe I et al (2012) Deficiency of tumour necrosis factor-related apoptosis-inducing ligand exacerbates lung injury and fibrosis.. Thorax, 67(9), 796-803. View this article in WRRO
Marriott HM, Gascoyne KA, Gowda R, Geary I, Nicklin MJH, Iannelli F, Pozzi G, Mitchell TJ, Whyte MKB, Sabroe I & Dockrell DH (2012) Interleukin-1β regulates CXCL8 release and influences disease outcome in response to Streptococcus pneumoniae, defining intercellular cooperation between pulmonary epithelial cells and macrophages.. Infect Immun, 80(3), 1140-1149. View this article in WRRO
McGrath EE, Marriott HM, Lawrie A, Francis SE, Sabroe I, Renshaw SA, Dockrell DH & Whyte MKB (2011) TNF-related apoptosis-inducing ligand (TRAIL) regulates inflammatory neutrophil apoptosis and enhances resolution of inflammation.. J Leukoc Biol, 90(5), 855-865. View this article in WRRO
Bewley MA, Pham TK, Marriott HM, Noirel J, Chu H-P, Ow SY, Ryazanov AG, Read RC, Whyte MKB, Chain B , Wright PC et al (2011) Proteomic evaluation and validation of cathepsin D regulated proteins in macrophages exposed to Streptococcus pneumoniae.. Mol Cell Proteomics, 10(6), M111.008193. View this article in WRRO
Walmsley SR, Chilvers ER, Thompson AA, Vaughan K, Marriott HM, Parker LC, Shaw G, Parmar S, Schneider M, Sabroe I , Dockrell DH et al (2011) Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice.. J Clin Invest, 121(3), 1053-1063. View this article in WRRO
Walmsley SR, Chilvers ER, Thompson A, Vaughan K, Marriott H, Parker L, Shaw G, Parmar S, Schneider M, Sabroe I , Dockrell D et al (2011) Prolyl Hydroxylase Phd3 Is Essential For Hypoxic Regulation Of Neutrophilic Inflammation. C13. PATHOGENESIS OF ACUTE LUNG INJURY.
Bewley MA, Marriott HM, Tulone C, Francis SE, Mitchell TJ, Read RC, Chain B, Kroemer G, Whyte MKB & Dockrell DH (2011) A cardinal role for cathepsin d in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci.. PLoS Pathog, 7(1), e1001262. View this article in WRRO
Webster SJ, Daigneault M, Bewley MA, Preston JA, Marriott HM, Walmsley SR, Read RC, Whyte MKB & Dockrell DH (2010) Distinct cell death programs in monocytes regulate innate responses following challenge with common causes of invasive bacterial disease.. J Immunol, 185(5), 2968-2979.
Daigneault M, Preston JA, Marriott HM, Whyte MK & Dockrell DH (2010) The identification of markers of macrophage differentiation in PMA-stimulated THP-1 cells and monocyte-derived macrophages.. PLoS One, 5(1), e8668. View this article in WRRO
Marriott HM, Mitchell TJ & Dockrell DH (2008) Pneumolysin: a double-edged sword during the host-pathogen interaction.. Curr Mol Med, 8(6), 497-509. View this article in WRRO
Marriott HM, Jackson LE, Wilkinson TS, Simpson AJ, Mitchell TJ, Buttle DJ, Cross SS, Ince PG, Hellewell PG, Whyte MKB & Dockrell DH (2008) Reactive oxygen species regulate neutrophil recruitment and survival in pneumococcal pneumonia.. Am J Respir Crit Care Med, 177(8), 887-895. View this article in WRRO
Prince LR, Bianchi SM, Vaughan KM, Bewley MA, Marriott HM, Walmsley SR, Taylor GW, Buttle DJ, Sabroe I, Dockrell DH & Whyte MKB (2008) Subversion of a lysosomal pathway regulating neutrophil apoptosis by a major bacterial toxin, pyocyanin.. J Immunol, 180(5), 3502-3511. View this article in WRRO
Bianchi SM, Prince LR, McPhillips K, Allen L, Marriott HM, Taylor GW, Hellewell PG, Sabroe I, Dockrell DH, Henson PW & Whyte MKB (2008) Impairment of apoptotic cell engulfment by pyocyanin, a toxic metabolite of Pseudomonas aeruginosa.. Am J Respir Crit Care Med, 177(1), 35-43. View this article in WRRO
Vaughan KR, Stokes L, Prince LR, Marriott HM, Meis S, Kassack MU, Bingle CD, Sabroe I, Surprenant A & Whyte MKB (2007) Inhibition of neutrophil apoptosis by ATP is mediated by the P2Y11 receptor.. J Immunol, 179(12), 8544-8553.
Marriott HM & Dockrell DH (2007) The role of the macrophage in lung disease mediated by bacteria.. Exp Lung Res, 33(10), 493-505. View this article in WRRO
Marriott HM, Hellewell PG, Whyte MKB & Dockrell DH (2007) Contrasting roles for reactive oxygen species and nitric oxide in the innate response to pulmonary infection with Streptococcus pneumoniae.. Vaccine, 25(13), 2485-2490. View this article in WRRO
Marriott HM, Hellewell PG, Cross SS, Ince PG, Whyte MKB & Dockrell DH (2006) Decreased alveolar macrophage apoptosis is associated with increased pulmonary inflammation in a murine model of pneumococcal pneumonia.. J Immunol, 177(9), 6480-6488. View this article in WRRO
Marriott HM & Dockrell DH (2006) Streptococcus pneumoniae: the role of apoptosis in host defense and pathogenesis.. Int J Biochem Cell Biol, 38(11), 1848-1854. View this article in WRRO
Tunbridge AJ, Stevanin TM, Lee M, Marriott HM, Moir JWB, Read RC & Dockrell DH (2006) Inhibition of macrophage apoptosis by Neisseria meningitidis requires nitric oxide detoxification mechanisms.. Infect Immun, 74(1), 729-733.
Marriott HM, Bingle CD, Read RC, Braley KE, Kroemer G, Hellewell PG, Craig RW, Whyte MKB & Dockrell DH (2005) Dynamic changes in Mcl-1 expression regulate macrophage viability or commitment to apoptosis during bacterial clearance. J CLIN INVEST, 115(2), 359-368. View this article in WRRO
Marriott HM, Bingle CD, Read RC, Braley KE, Kroemer G, Hellewell PG, Craig RW, Whyte MKB & Dockrell DH (2005) Dynamic changes in Mcl-1 expression regulate macrophage viability or commitment to apoptosis during bacterial clearance. Journal of Clinical Investigation, 115(2), 359-368.
Marriott HM, Ali F, Read RC, Mitchell TJ, Whyte MKB & Dockrell DH (2004) Nitric oxide levels regulate macrophage commitment to apoptosis or necrosis during pneumococcal infection.. FASEB J, 18(10), 1126-1128. View this article in WRRO
Dockrell DH, Marriott HM, Prince LR, Ridger VC, Ince PG, Hellewell PG & Whyte MKB (2003) Alveolar macrophage apoptosis contributes to pneumococcal clearance in a resolving model of pulmonary infection.. J Immunol, 171(10), 5380-5388. View this article in WRRO
DEMONCHEAUX EAG, HIGENBOTTAM TW, FOSTER PJ, BORLAND CDR, SMITH APL, MARRIOTT HM, BEE D, AKAMINE S & DAVIES MB (2002) Is circulating nitrite a directly acting vasodilator?: authors’ reply. Clinical Science, 103(1), 107-107.
DEMONCHEAUX EAG, HIGENBOTTAM TW, FOSTER PJ, BORLAND CDR, SMITH APL, MARRIOTT HM, BEE D, AKAMINE S & DAVIES MB (2002) Is circulating nitrite a directly acting vasodilator?: authors’ reply. Clinical Science, 103(1), 107-107.
Demoncheaux EAG, Higenbottam TW, Foster PJ, Borland CDR, Smith APL, Marriott HM, Bee D, Akamine S & Davies MB (2002) Is circulating nitrite a directly acting vasodilator?: authors' reply. CLIN SCI, 103(1), 108-110.
DEMONCHEAUX EAG, HIGENBOTTAM TW, FOSTER PJ, BORLAND CDR, SMITH APL, MARRIOTT HM, BEE D, AKAMINE S & DAVIES MB (2002) Circulating nitrite anions are a directly acting vasodilator and are donors for nitric oxide. Clinical Science, 102(1), 77-83.
Demoncheaux EAG, Higenbottam TW, Foster PJ, Borland CDR, Smith APL, Marriott HM, Bee D, Akamine S & Davies MB (2002) Circulating nitrite anions are a directly acting vasodilator and are donors for nitric oxide.. Clin Sci (Lond), 102(1), 77-83.
Higenbottam T, Marriott H, Cremona G, Laude E & Bee D (1999) The Acute Effects of Dexfenfluramine on Human and Porcine Pulmonary Vascular Tone and Resistance. Chest, 116(4), 921-930.
Higenbottam T, Marriott H, Siddons T & Smith A (1998) Primary and Secondary Pulmonary Hypertension. Seminars in Respiratory and Critical Care Medicine, 19(01), 91-95.
Marriott H & Higenbottam T (1997) The role of nitric oxide in respiratory disease. Schweizerische Medizinische Wochenschrift, 127(17), 709-714.
Bazaz R, Marriott HM, Wright C, Chamberlain J, West LE, Gelsthorpe C, Heath PR, Maleki-Dizaji A, Francis SE & Dockrell DH () Transient increase in atherosclerotic plaque macrophage content following Streptococcus pneumoniae pneumonia in ApoE-deficient mice. Frontiers in Cellular and Infection Microbiology, 13.
Herman KD, Wright CG, Marriott HM, McCaughran SC, Bowden KA, Collins MO, Renshaw SA & Prince LR () The EGFR/ErbB inhibitor neratinib modifies the neutrophil phosphoproteome and promotes apoptosis and clearance by airway macrophages. Frontiers in Immunology, 13.
Masca NGD, Hensor EMA, Cornelius VR, Buffa FM, Marriott HM, Eales JM, Messenger MP, Anderson AE, Boot C, Bunce C , Goldin RD et al () RIPOSTE: a framework for improving the design and analysis of laboratory-based research. eLife, 4. View this article in WRRO
Hatzifoti C, Bacon A, Marriott H, Laing P & Heath AW () Liposomal Co-Entrapment of CD40mAb Induces Enhanced IgG Responses against Bacterial Polysaccharide and Protein. PLoS ONE, 3(6), e2368-e2368. View this article in WRRO
Rudman J, Marriott HM, Carlin LM & Johnston SA () The mouse lung early cellular innate immune response is not sufficient to control fungal infection with Cryptococcus neoformans.

Chapters

Dockrell DH, Collini PJ & Marriott HM (2013) Alveolar Macrophages, Mucosal Immunology of Acute Bacterial Pneumonia (pp. 1-48). Springer New York
Marriott HM & Higenbottam TW (2000) Inhaled Nitric Oxide as a Therapy for Diseases of the Pulmonary Vasculature, Nitric Oxide in Pulmonary Processes: Role in Physiology and Pathophysiology of Lung Disease (pp. 201-208). Birkhäuser Basel

Conference proceedings papers

Marsh EK, Prestwich EC, Marriott HM, Williams L, Hart AR, Muir CF, Parker LC, Jonker MR, Heijink IH, Timens W , Fife M et al (2018) S98 Pellino-1 regulates the responses of the airway to viral infection. The influence of influenza: from cells to humans
Braithwaite AT, Pickworth JA, Arnold ND, West LE, Iremonger JE, Thompson AA, Marriott HM & Lawrie A (2018) T6 Vascular smooth muscle derived TRAIL underlies pulmonary vascular remodelling in sugen 5416/hypoxia mice. BTS/BALR/BLF Early Career Investigators awards symposium
Braithwaite AT, Pickworth JA, Arnold ND, West LE, Iremonger JE, Thompson AA, Marriott HM & Lawrie A (2018) Vascular Smooth Muscle Derived TRAIL is Required for Development of Pulmonary Arterial Hypertension in Sugen 5416 / Hypoxia Mice. CIRCULATION, Vol. 138
Dickinson RS, Thompson AAR, Thomson JP, Murphy F, Marriott HM, Tavares A, Willson J, Williams L, Lewis A, Forbes S , Stimson RH et al (2016) S104 Hypoxia preconditions the innate immune response to acute bacterial pulmonary infections. Thorax, Vol. 71(Suppl 3) (pp A61.2-A62)
Marsh EK, Prestwich EC, Marriott HM, Paiva C, Bennett JA, Jonker MR, Timens W, Heijink IH, Parker LC, Dockrell DH & Sabroe I (2016) The Role Of Pellino-1 In Modulating Signalling Pathways Controlling The Inflammatory Response To Viral Stimuli In Airway Epithelial Cells. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 193
Gill SK, Marriott HM, Peachell PT & Immunity DI (2014) Prostaglandin E2 Activates Ep4 Receptors To Inhibit Pro-Inflammatory Cytokine Release From Human Lung Macrophages. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 189
Bingle CD, Araujo B, Wallace WA, Marriott HM, Hirani N & Bingle L (2013) BPIFB1/LPLUNC1 IS A NOVEL MARKER FOR THE BRONCHIOLISED EPITHELIUM IN IPF. THORAX, Vol. 68 (pp A139-A139)
Thompson AAR, Marriott HM, Williams L, Shaw G, Hameed A, Parmar S, Preston JA, Simon MC, Johnson RS, Foster SJ , Dockrell DH et al (2013) HYPOXIA INDUCES HYPOTHERMIA AND SICKNESS BEHAVIOUR IN MICE FOLLOWING SUBCUTANEOUS INJECTION OF LIVE STAPHYLOCOCCUS AUREUS. THORAX, Vol. 68 (pp A140-A140)
Thompson AAR, Elks PM, Marriott HM, Higgins KR, Parmar S, Shaw G, Eamsamarng S, McGrath EE, Formenti F, Van Eeden FJ , Kinnula VL et al (2012) HYPOXIA-INDUCIBLE FACTOR 2 alpha REGULATES NEUTROPHILIC INFLAMMATION IN HUMANS, MICE AND ZEBRAFISH. THORAX, Vol. 67 (pp A1-A1)
Araujo B, Bingle L, Marriott H, Howie S, Wallace W, Hirani N & Bingle CD (2012) LPLUNC1 (BPIFB1) As A Novel Marker For The Abnormal Epithelium In Pulmonary Fibrosis. B28. EMERGING BIOMARKERS OF COMPLEX LUNG DISEASES
Thompson AAR, Elks PM, Marriott HM, Higgins KR, Shaw G, Parmar S, Formenti F, Van Eden FJ, Pugh CW, Sabroe I , Dockrell DH et al (2012) HIF-2± Regulates Neutrophilic Inflammation In Humans, Mice And Zebrafish. C31. REGULATION OF LUNG INFLAMMATION
McGrath EE, Lawrie A, Marriott H, Mercer PF, Cross SS, Chambers RC, Dockrell DH & Whyte MKB (2011) S111 The role of TNF-related apoptosis inducing ligand (TRAIL) in pulmonary fibrosis. Thorax, Vol. 66(Suppl 4) (pp A51-A52)
McGrath EE, Marriott H, Lawrie A, Cross S, Mercer P, Hellewell P, Chambers RC, Dockrell D & Whyte MK (2011) The Role Of TNF-Related Apoptosis Inducing Ligand (TRAIL) In Idiopathic Pulmonary Fibrosis (IPF). D14. INSIGHTS INTO PATHOGENESIS OF LUNG FIBROSIS AND GRANULOMAS
Marriott HM, Whyte M & Dockrell D (2011) Fas Ligand Contributes To The Pulmonary Response To Streptococcus Pneumoniae. A35. LESSONS IN LUNG INFECTIONS
Webster SJ, Daigneault M, Marriott HM, Bewley MA, Read RC & Dockrell DH (2010) MONOCYTE DEATH PROCESSES ARE SUBVERTED BY MENINGOCOCCI. J INFECTION, Vol. 61(6) (pp 517-518)
Daigneault M, Collini P, Marriott HM, Preston J, Mitchell T & Dockrell D (2010) Monocytes promote T-lymphocyte apoptosis following Streptococcus pneumoniae challenge. IMMUNOLOGY, Vol. 131 (pp 179-179)
Marriott HM & Dockrell DH (2010) Regulation Of Apoptosis In A549 Cells After Influenza A Virus Infection. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 181
Marriott HM, Whyte MK & Dockrell DH (2009) Macrophage Apoptosis after Influenza A Virus Infection.. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 179
Mcgrath EE, Marriott HM, Hellewell PG, Dockrell DH & Whyte MK (2007) The role of TNF-related apoptosis inducing ligand in acute lung injury. THORAX, Vol. 62 (pp A62-A62)
Marriott HM, Read RC, Whyte MKB & Dockrell DH (2007) Maintenance of macrophage viability after meningococcal infection. IMMUNOLOGY, Vol. 120 (pp 82-82)
Marriott HM, Hellewell PG, Whyte MK & Dockrell DH (2005) Apoptotic macrophages limit inflammation in pneumococcal pneumonia. JOURNAL OF LEUKOCYTE BIOLOGY (pp 77-77)
Eneser M, Barer GR, Marriott HM & Emery CJ (2002) Quantification of pulmonary haemodynamic and vascular changes in chronic hypoxia and recovery in rats. JOURNAL OF PHYSIOLOGY-LONDON, Vol. 544 (pp 116P-116P)
Eneser M, Marriott HM, Emery CJ & Higenbottam TW (2001) Reversal of pulmonary hypertension and vascular remodelling by an endothelin receptor antagonist in the chronic hypoxic rat model. THORAX, Vol. 56 (pp 75-76)
Marriott HM, Emery CJ & Barer GR (2001) Fawn-hooded rats and pulmonary hypertension: histological and haemodynamic comparison with Wistar rats. J PHYSIOL-LONDON, Vol. 533 (pp 80P-81P)
Emery CJ, Lal H, Marriot HM, Whittle BJR, Shorr R, Bentley M, Zhao X & Higenbottam TW (2000) Pulmonary vasodilation by airway delivered prostacyclin analogues, UT-15 & pegylated UT-15. THORAX, Vol. 55 (pp A35-A35)
Marriott HM, Smith APL, Gonzalez AM, Emery CJ & Higenbottam TW (1999) Chronic dexfenfluramine treatment reduces the levels of serotonin transporter mRNA in normoxic and chronically hypoxic Wistar and Fawn hooded rats.. THORAX, Vol. 54 (pp A40-A40)
Emery CJ, Marriott HM, Laude EA, Prevost L & Higenbottam TW (1999) Pulmonary vasoactivity of fenfluramines and selective serotonin reuptake inhibitors, fluoxetine and amitriptyline, in the rat. THORAX, Vol. 54 (pp A40-A40)
Marriott HM, Emery CJ & Higenbottam TW (1999) Inhalation of endothelin(A/B) receptor antagonist partially reverses chronic hypoxic pulmonary hypertension in the rat. THORAX, Vol. 54 (pp A40-A40)
Patel R, Marriott HM, Emery CJ, McCormack K, Smith APL & Higenbottam TW (1999) Anti-ET-1 oligonucleotides as a potential treatment for pulmonary hypertension.. THORAX, Vol. 54 (pp A39-A39)
Patel R, Marriott HM, Smith APL, Emery CJ & Higenbottam TW (1999) Transfer of phosphorothioate oligodeoxynucleotides from the airway to the perfusate in isolated perfused rat lungs. AM J RESP CRIT CARE, Vol. 159(3) (pp A168-A168)
Marriott HM, Smith APL, Gonzalez AM, Emery CJ & Higenbottam TW (1999) Chronic dexfenfluramine treatment reduces the levels of serotonin transporter mRNA in normoxic and chronically hypoxic wistar and fawn hooded rats.. AM J RESP CRIT CARE, Vol. 159(3) (pp A168-A168)
Emery CJ, Marriott HM, Laude EA, Bee D & Higenbottam TW (1999) Attenuated pulmonary and systemic vasodilator response to serotonin in the Fawn Hooded rat. AM J RESP CRIT CARE, Vol. 159(3) (pp A165-A165)
Emery CJ, Phillips HM, Marriott HM, Laude EA & Bee D (1998) Pulmonary and systemic action of 5-HT in the Fawn Hooded rat: a model of inherited pulmonary and systemic hypertension. J PHYSIOL-LONDON, Vol. 511P (pp 108P-109P)
Marriott HM, Smith APL, Emery CJ & Higenbottam TW (1998) Rapid increases in the levels of preproendothelin-1 mRNA in the isolated perfused rat lung exposed to acute hypoxia. Thorax, Vol. 53(SUPPL. 4)
Laude EA, Emery CJ, Marriott HM & Higenbottam TW (1998) Altered vascular reactivity to serotonin in the fawn hooded rat; a model of spontaneous pulmonary and systemic hypertension. Thorax, Vol. 53(SUPPL. 4)
Marriott H, Akamine S & Higenbottam TW (1997) The effect of dexfenfluramine on 5-hydroxytryptamine clearance in the porcine lung. Thorax, Vol. 52(SUPPL. 6)
Marriott HM, Laude EA, Emery CJ & Higenbottam TW (1997) Enhanced pulmonary vasoreactivity to serotonin in the Fawn hooded rat. Thorax, Vol. 52(SUPPL. 6)

Preprints

Herman KD, Wright CG, Marriott HM, McCaughran SC, Collins MO, Renshaw SA & Prince LR () The EGFR/ErbB inhibitor neratinib modifies the neutrophil phosphoproteome and promotes apoptosis and clearance by airway macrophages, Cold Spring Harbor Laboratory.
Bazaz R, Marriott H, Wright C, Chamberlain J, West L, Gelsthorpe C, Heath P, Maleki-Dizaji A, Francis S & Dockrell D () Transient increase in atherosclerotic plaque macrophage content following Streptococcus pneumoniae pneumonia in ApoE-deficient mice, Research Square Platform LLC.
Mohasin M, Balbirnie-Cumming K, Fisk E, Prestwich EC, Russell CD, Marshall J, Pridans C, Allen SP, Shaw PJ, De Vos KJ , Hill CJ et al () Mitochondrial fission is increased in macrophages during mROS production in response to S. pneumoniae, Cold Spring Harbor Laboratory.
Rizzello L, Robertson JD, Elks PM, Poma A, Daneshpour N, Prajsnar TK, Evangelopoulos D, Canseco JO, Yona S, Marriott HM , Dockrell DH et al () Targeting mononuclear phagocytes for eradicating intracellular parasites, Cold Spring Harbor Laboratory.

Teaching activities

I contribute to several modules in the MSc in Molecular Medicine. I am the module leader for the following modules:

Modulating Immunity
Molecular and Cellular Basis of Disease
Pathogenicity of Viruses and Fungi

I am also the lead for the Experimental Medicine pathway.

I contribute to the teaching and supervision of students in the Medical School MBChB and Molecular Biology and Biotechnology BSc and MBiolSci courses.

I also teach the Postgraduate Induction course of the Faculty of Health and am the unfair means officer for the Medical School (PGR).

Professional activities and memberships

Member of University of Sheffield Animal Welfare and Ethical Review Board / 3Rs Committee