Dr Greg Wells

BSc (Hons), PhD.

Clinical Medicine, School of Medicine and Population Health

Ex vivo Project Lead

Dr Greg Wells
Dr Greg Wells
Profile picture of Dr Greg Wells
g.wells@sheffield.ac.uk
+44 114 215 9077

Full contact details

Dr Greg Wells
Clinical Medicine, School of Medicine and Population Health
FU03, F Floor
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Profile

For enquiries, please contact - SMPH-West-Operational@sheffield.ac.uk

I studied biomedical science at Sheffield Hallam University in 2013 where I was awarded the President’s Prize from the Institute of Biomedical Science, the Undergraduate Prize from the British Society for Immunology, and the Pfizer Global R&D Prize for best performance in Analytical Science.

Following this I worked in industry, designing and validating genetic based assays for clinical trials in a GLP compliant laboratory. I then undertook a PhD between the University of Sheffield, Sheffield Diagnostics Genetics Services NHS and AstraZeneca investigating genetics biomarkers and transcriptomic signatures in lung cancer.

In 2020 I established the ex vivo drug screening group at the University of Sheffield.

Research interests

My research interests are developing and advancing clinically relevant methods of patient stratification to targeted oncology therapeutics. Genetic biomarkers have dominated personal medicine for the last 20 years, but it is becoming clear that one molecular aberration may not drive the whole neoplastic process, so this approach does not always result in responses to molecular targeted therapy.

At the University of Sheffield alongside collaborators we are developing a phenotypic drug screen which can be used directly on a patient’s biopsy or surgical tissue to generate a pharmacological profile of the patient’s tumour. We are currently testing this methodology in the proof of concept EVIvo DEtermiNed cancer Therapy (EVIDENT) trial. Our aim is to develop this into a predictive diagnostic test used to direct cancer patients’ treatment, adding an extra dimension to precision medicine.

Publications

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Journal articles

All publications

Journal articles

Conference proceedings papers

Presentations

  • Wells G Utilising ex vivo imaging to measure drug action at the single cell level using a live biopsy. Nottingham. RIS download Bibtex download
  • Wells G Ex vivo Determined Cancer Therapy. Sheffield. RIS download Bibtex download
Research group
  • Prof Sarah Danson (Clinical Lead)
  • Dr Hannah Gagg (Postdoctoral Research Associate)
  • Dr Jamie Adams (Postdoctoral Research Associate / Image Specialist)
  • Dr Nikita Lad (Postdoctoral Research Associate)
  • Dr Alberto Biancardi (Image Computing Staff Scientist)
  • Ms Helen Shulver (Senior Research Technician, QA)
  • Dr Rachel Turner (Research Technician)
  • Ms Angela Green (Senior Research Nurse)
  • Ms Vicky Hallworth (Senior Research Nurse)
  • Ms Sarah Clarke (Clinical Trials Assistant)
  • Dr Md Marufur Rahman (Clinical PhD Student)
  • Ms Miriam Arrulo (PhD Student)
  • Mr Louis Lane (PhD Student)
  • Mr Callum Blee (PhD Student)
Grants
  • Yorkshire Cancer Research Programme Award
  • Western Park Cancer Charity
  • LifeArc
  • Medical Research Council
Teaching activities
  • Msc – Cancer Biology and Therapeutics
  • MSc - Molecular Medicine