Dr Gordon Sloan

MBChB, PhD

Clinical Medicine, School of Medicine and Population Health

NIHR Clinical Lecturer in Diabetes and Endocrinology

gordon.sloan@sheffield.ac.uk

Room FU32, F Floor, The Medical School

Full contact details

Dr Gordon Sloan
Clinical Medicine, School of Medicine and Population Health
Room FU32, F Floor
The Medical School
Beech Hill Road
Sheffield
S10 2RX

Profile

I am a clinical scientist, with a specialist interest in the field of neurological complications of diabetes mellitus.

I completed my undergraduate training at the University of Sheffield in 2011. During this training I completed an intercalated BMedSci where I developed an interest in research. I then undertook clinical training in South Yorkshire, and commenced specialist training in Diabetes and Endocrinology in 2015. I commenced a Clinical Research Fellowship at Sheffield Teaching Hospitals NHS Foundation Trust in 2017 and defended my PhD in 2022, which was entitled ‘Central Biomarkers of Painful Diabetic Peripheral Neuropathy’. Since 2022 I have been a NIHR Academic Clinical Lecturer working in the Division of Clinical Medicine.

Research interests: My research interests lie in developing a greater understanding of the mechanisms which underlie Diabetic Peripheral Neuropathy. In particular, I have utilized neuroimaging techniques to determine the cerebral alterations which differentiate Painful- compared with Painless-Diabetic Peripheral Neuropathy.

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Elliott J, Sloan G, Stevens L, Selvarajah D, Cruccu G, Gandhi RA, Kempler P, Fuller JH, Chaturvedi N & Tesfaye S (2024) Female sex is a risk factor for painful diabetic peripheral neuropathy: the EURODIAB prospective diabetes complications study. Diabetologia, 67(1), 190-198. View this article in WRRO
Sloan G, Anton A, Caunt S, Wilkinson I, Selvarajah D & Tesfaye S (2023) Higher Sensory Cortical Energy Metabolism in Painful Diabetic Neuropathy: Evidence From a Cerebral Magnetic Resonance Spectroscopy Study. Diabetes, 72(7), 1028-1034.
Selvarajah D, Sloan G, Teh K, Wilkinson ID, Heiberg-Gibbons F, Awadh M, Kelsall A, Grieg M, Pallai S & Tesfaye S (2023) Structural Brain Alterations in Key Somatosensory and Nociceptive Regions in Diabetic Peripheral Neuropathy. Diabetes Care, 46(4), 777-785.
Tesfaye S, Sloan G, Petrie J, White D, Bradburn M, Julious S, Rajbhandari S, Sharma S, Rayman G, Gouni R , Alam U et al (2022) Comparison of amitriptyline supplemented with pregabalin, pregabalin supplemented with amitriptyline, and duloxetine supplemented with pregabalin for the treatment of diabetic peripheral neuropathic pain (OPTION-DM): a multicentre, double-blind, randomised crossover trial. The Lancet, 400(10353), 680-690. View this article in WRRO
Sloan G, Alam U, Selvarajah D & Tesfaye S (2022) The Treatment of Painful Diabetic Neuropathy. Current Diabetes Reviews, 18(5).
Sloan G, Selvarajah D & Tesfaye S (2021) Pathogenesis, diagnosis and clinical management of diabetic sensorimotor peripheral neuropathy. Nature Reviews Endocrinology, 17(7), 400-420.
Teh K, Wilkinson ID, Heiberg-Gibbons F, Awadh M, Kelsall A, Pallai S, Sloan G, Tesfaye S & Selvarajah D (2021) Somatosensory network functional connectivity differentiates clinical pain phenotypes in diabetic neuropathy. Diabetologia, 64(6), 1412-1421. View this article in WRRO
Wilkinson ID, Teh K, Heiberg-Gibbons F, Awadh M, Kelsall A, Shillo P, Sloan G, Tesfaye S & Selvarajah D (2020) Determinants of Treatment Response in Painful Diabetic Peripheral Neuropathy: A Combined Deep Sensory Phenotyping and Multimodal Brain MRI Study. Diabetes, 69(8), 1804-1814.
Shillo P, Sloan G, Greig M, Hunt L, Selvarajah D, Elliott J, Gandhi R, Wilkinson ID & Tesfaye S (2019) Painful and Painless Diabetic Neuropathies: What Is the Difference?. Current Diabetes Reports, 19. View this article in WRRO
Sloan G, Shillo P, Selvarajah D, Wu J, Wilkinson ID, Tracey I, Anand P & Tesfaye S (2018) A new look at painful diabetic neuropathy. Diabetes Research and Clinical Practice, 144, 177-191. View this article in WRRO

All publications

Journal articles

SHAAN GOONOO M, SELVARAJAH D, SLOAN GP & TESFAYE S (2024) 11-OR: Combined DPNCheck and SUDOSCAN as a Screening Tool for DPN—The Sheffield Prospective Study. Diabetes, 73(Supplement_1).
Elliott J, Sloan G, Stevens L, Selvarajah D, Cruccu G, Gandhi RA, Kempler P, Fuller JH, Chaturvedi N & Tesfaye S (2024) Female sex is a risk factor for painful diabetic peripheral neuropathy: the EURODIAB prospective diabetes complications study. Diabetologia, 67(1), 190-198. View this article in WRRO
SHAAN GOONOO M, SELVARAJAH D, SLOAN GP & TESFAYE S (2023) 489-P: Abnormal Combined Point-of-Care-Device DPN-Check and SUDOSCAN Results Predict All-Cause Mortality in People with Diabetes. Diabetes, 72(Supplement_1).
SLOAN GP, TEH K, RAPPAI SHILLO P, TESFAYE S, SELVARAJAH D & WILKINSON ID (2023) 478-P: Brain Volume Changes after Long-Term Opioid Treatment in Painful Diabetic Peripheral Neuropathy. Diabetes, 72(Supplement_1).
SLOAN GP, TEH K, SELVARAJAH D & TESFAYE S (2023) 477-P: Thalamic Mitochondrial and Neuronal Function Is Preserved in Painful Diabetic Peripheral Neuropathy—A Multimodal Magnetic Resonance Imaging Study. Diabetes, 72(Supplement_1).
SELVARAJAH D, TEH K, ANANDHANARAYANAN A, SLOAN GP & TESFAYE S (2023) 104-OR: Identifying Painful Diabetic Neuropathy Subtypes from Resting-State Functional Magnetic Resonance Brain Imaging—A Novel Unsupervised Machine Learning Approach. Diabetes, 72(Supplement_1).
Sloan G, Anton A, Caunt S, Wilkinson I, Selvarajah D & Tesfaye S (2023) Higher Sensory Cortical Energy Metabolism in Painful Diabetic Neuropathy: Evidence From a Cerebral Magnetic Resonance Spectroscopy Study. Diabetes, 72(7), 1028-1034.
Selvarajah D, Sloan G, Teh K, Wilkinson ID, Heiberg-Gibbons F, Awadh M, Kelsall A, Grieg M, Pallai S & Tesfaye S (2023) Structural Brain Alterations in Key Somatosensory and Nociceptive Regions in Diabetic Peripheral Neuropathy. Diabetes Care, 46(4), 777-785.
Tesfaye S, Sloan G, White D, Bradburn M, Bouhassira D & Selvarajah D (2023) Who really benefits from drug combinations and long titrations for pain? – Authors' reply. The Lancet, 401(10372), 192-193. View this article in WRRO
Gandhi R, Selvarajah D, Sloan G, Greig M, Wilkinson ID, Shaw PJ, Griffiths P & Tesfaye S (2023) Preservation of thalamic neuronal function may be a prerequisite for pain perception in diabetic neuropathy: a magnetic resonance spectroscopy study. Frontiers in Pain Research, 3. View this article in WRRO
Tesfaye S, Sloan G, Petrie J, White D, Bradburn M, Young T, Rajbhandari S, Sharma S, Rayman G, Gouni R , Alam U et al (2022) Optimal pharmacotherapy pathway in adults with diabetic peripheral neuropathic pain: the OPTION-DM RCT. Health Technology Assessment, 26(39). View this article in WRRO
Tesfaye S, Sloan G, Petrie J, White D, Bradburn M, Julious S, Rajbhandari S, Sharma S, Rayman G, Gouni R , Alam U et al (2022) Comparison of amitriptyline supplemented with pregabalin, pregabalin supplemented with amitriptyline, and duloxetine supplemented with pregabalin for the treatment of diabetic peripheral neuropathic pain (OPTION-DM): a multicentre, double-blind, randomised crossover trial. The Lancet, 400(10353), 680-690. View this article in WRRO
GREIG M, SLOAN GP, SHILLO PR, SELVARAJAH D, WILKINSON ID & TESFAYE S (2022) 85-OR: Thalamic H1-MRS Metabolite Parameters Are Related to Mood Disorders in Type 1 Diabetes. Diabetes, 71(Supplement_1).
TEH K, SLOAN GP, WILKINSON ID, TESFAYE S & SELVARAJAH D (2022) 84-OR: Responders to Neuropathic Pain Treatment Have Greater Target Engagement of Opioid Receptor Systems: A Resting State Functional Magnetic Resonance Imaging Study in Painful Diabetic Neuropathy. Diabetes, 71(Supplement_1).
SLOAN GP, SELVARAJAH D, TEH K & TESFAYE S (2022) 457-P: Increase in Functional Connectivity of the Thalamus to the Primary Somatosensory Cortex and Insular Cortex after Withdrawal of Neuropathic Pain Medication: A Potential Biomarker of Painful-DPN. Diabetes, 71(Supplement_1).
TEH K, WILKINSON ID, SLOAN GP, TESFAYE S & SELVARAJAH D (2022) 455-P: Artificial Intelligence Approach to Treatment Classification in Painful Diabetic Neuropathy. Diabetes, 71(Supplement_1).
Sloan G, Alam U, Selvarajah D & Tesfaye S (2022) The Treatment of Painful Diabetic Neuropathy. Current Diabetes Reviews, 18(5).
Tesfaye S & Sloan G (2021) Involvement of the central nervous system in diabetic distal symmetrical polyneuropathy. Journal of Xiangya Medicine, 6. View this article in WRRO
TEH K, WILKINSON ID, SHILLO PR, SLOAN GP, TESFAYE S & SELVARAJAH D (2021) 422-P: Intrinsic Brain Connectivity in Chronic Painful Diabetic Neuropathy: A Resting-State fMRI Study. Diabetes, 70(Supplement_1).
SLOAN GP, SELVARAJAH D, TEH K, SHILLO PR, WILKINSON ID & TESFAYE S (2021) 210-OR: Cerebral Morphometric Alterations in Painless and Painful Diabetic Peripheral Neuropathy. Diabetes, 70(Supplement_1).
GREIG M, SLOAN GP, SHILLO PR, SELVARAJAH D, WILKINSON ID & TESFAYE S (2021) 423-P: Altered Microvascular Perfusion of the Pain-Processing Areas of the Brain during the Experience of Spontaneous Neuropathic Pain. Diabetes, 70(Supplement_1).
Sloan G, Selvarajah D & Tesfaye S (2021) Pathogenesis, diagnosis and clinical management of diabetic sensorimotor peripheral neuropathy. Nature Reviews Endocrinology, 17(7), 400-420.
Teh K, Wilkinson ID, Heiberg-Gibbons F, Awadh M, Kelsall A, Pallai S, Sloan G, Tesfaye S & Selvarajah D (2021) Somatosensory network functional connectivity differentiates clinical pain phenotypes in diabetic neuropathy. Diabetologia, 64(6), 1412-1421. View this article in WRRO
Alam U, Sloan G & Tesfaye S (2020) Authors’ Reply to Eerdekens et al. “Treating Pain in Diabetic Neuropathy: Current and Developmental Drugs”. Drugs, 80(11), 1141-1143.
SLOAN GP, ANTON A, SELVARAJAH D, TESFAYE S & WILKINSON ID (2020) 129-OR: Abnormal Mitochondrial Activity in Pain Processing Regions of the Brain in Painful Diabetic Peripheral Neuropathy. Diabetes, 69(Supplement_1).
TEH K, WILKINSON ID, SLOAN GP, TESFAYE S & SELVARAJAH D (2020) 533-P: Predicting Treatment Response in Painful Diabetic Neuropathy Using Magnetic Resonance Brain Imaging. Diabetes, 69(Supplement_1).
Wilkinson ID, Teh K, Heiberg-Gibbons F, Awadh M, Kelsall A, Shillo P, Sloan G, Tesfaye S & Selvarajah D (2020) Determinants of Treatment Response in Painful Diabetic Peripheral Neuropathy: A Combined Deep Sensory Phenotyping and Multimodal Brain MRI Study. Diabetes, 69(8), 1804-1814.
Tesfaye S & Sloan G (2020) Diabetic Polyneuropathy – Advances in Diagnosis and Intervention Strategies. European Endocrinology, 16(1), 15-15.
Alam U, Sloan G & Tesfaye S (2020) Treating Pain in Diabetic Neuropathy: Current and Developmental Drugs. Drugs, 80(4), 363-384.
Yang H, Sloan G, Ye Y, Wang S, Duan B, Tesfaye S & Gao L (2020) New perspective in diabetic neuropathy: From the periphery to the brain, a call for early detection, and precision medicine. Frontiers in Endocrinology, 10. View this article in WRRO
SELVARAJAH D, TEH K, SLOAN GP, SHILLO PR, WILKINSON ID & TESFAYE S (2019) 326-OR: A Novel Machine Learning Analysis of Brain Multimodal Magnetic Resonance Imaging Classifies Painful Diabetic Neuropathic Pain Severity with High Accuracy. Diabetes, 68(Supplement_1).
Shillo P, Sloan G, Greig M, Hunt L, Selvarajah D, Elliott J, Gandhi R, Wilkinson ID & Tesfaye S (2019) Painful and Painless Diabetic Neuropathies: What Is the Difference?. Current Diabetes Reports, 19. View this article in WRRO
Sloan G, Shillo P, Selvarajah D, Wu J, Wilkinson ID, Tracey I, Anand P & Tesfaye S (2018) A new look at painful diabetic neuropathy. Diabetes Research and Clinical Practice, 144, 177-191. View this article in WRRO
Sloan G, Kakoudaki T & Ranjan N (2018) Prolonged diabetic ketoacidosis associated with canagliflozin. Endocrinology, Diabetes & Metabolism Case Reports, 2018.
Sloan G, Ali A & Webster J (2017) A rare cause of metabolic acidosis: ketoacidosis in a non-diabetic lactating woman. Endocrinology, Diabetes & Metabolism Case Reports, 2017.
Sloan G, Donatien P, Privitera R, Shillo P, Caunt S, Selvarajah D, Anand P & Tesfaye S () Vascular and nerve biomarkers in thigh skin biopsies differentiate painful from painless diabetic peripheral neuropathy. Frontiers in Pain Research, 5.
Sloan G, Dela Pena P, Andag‐Silva A, Cunanan E, Jimeno C, Robles JJ & Tesfaye S () Sheffield One‐Stop Service: A potential model to improve the screening uptake of diabetic peripheral neuropathy and other microvascular complications of diabetes. Journal of Diabetes Investigation.
Sloan G, Teh K, Caunt S, Wilkinson I, Selvarajah D & Tesfaye S () Increased thalamocortical functional connectivity on discontinuation of treatment in painful diabetic peripheral neuropathy. Diabetes.
Shillo P, Sloan G, Selvarajah D, Greig M, Gandhi R, Anand P, Edden RA, Wilkinson ID & Tesfaye S () Reduced Thalamic Gamma Aminobutyric Acid (GABA) in Painless but not Painful Diabetic Peripheral Neuropathy. Diabetes.
Berry S, Sloan G, Reed E, Brown C & Allahabadia A () Radioactive Iodine Therapy in Benign Thyroid Disease - results from implementing 2007 RCP Guidelines. Endocrine Abstracts.

Chapters

Viswanathan V, shankari S & Sloan G (2024) Diabetic Foot Complications and Challenges, Management of Diabetic Complications (pp. 301-318). Springer Nature Singapore
Sloan G, Pan Q, Gao L, Guo L & Tesfaye S (2023) Clinical Features of Diabetes Neuropathies, Contemporary Diabetes (pp. 37-49). Springer International Publishing
Selvarajah D, Sloan G & Tesfaye S (2020) Diabetic Neuropathy (pp. 89-103). Wiley

Conference proceedings papers

Binns-Hall O, White J, Goonoo MS, Walker J, Sloan G, Gandhi R & Selvarajah D (2023) Real-world evaluation of OpSite topical dressing in painful diabetic neuropathy. DIABETIC MEDICINE, Vol. 40
Teh K, McAllister J, Anandhanarayanan A, Sloan G, Tesfaye S & Selvarajah D (2023) A novel data driven machine learning approach to identify painful diabetic neuropathy subtypes from resting-state functional magnetic resonance brain imaging. DIABETIC MEDICINE, Vol. 40
Goonoo MS, Selvarajah D, Binns-Hall O, Sloan G, Walker J & Tesfaye S (2023) Abnormal combined diabetic peripheral neuropathy (DPN)-check and SUDOSCAN results predict all-cause mortality in people with diabetes: The Sheffield prospective study. DIABETIC MEDICINE, Vol. 40
Sloan G, Selvarajah D, Anton A, Teh K, Shillo P, Greig M, Goonoo M, Caunt S, Wilkinson ID & Tesfaye S (2023) Preservation of thalamic mitochondrial and neuronal function in painful diabetic peripheral neuropathy: A multi-modal magnetic resonance imaging study. DIABETIC MEDICINE, Vol. 40
Goonoo M, Selvarajah D, Binns-Hall O, Sloan G, Walker J & Tesfaye S (2023) Abnormal combined DPN-check and Sudoscan results predict all-cause mortality in people with diabetes: the Sheffield prospective study. DIABETOLOGIA, Vol. 66(SUPPL 1) (pp S469-S469)
Selvarajah D, Teh K, Sloan G, Pallai S & Tesfaye S (2023) Cerebral dopamine receptor engagement and treatment response: a resting-state functional magnetic resonance imaging study in painful diabetic neuropathy. DIABETOLOGIA, Vol. 66(SUPPL 1) (pp S469-S469)
Sloan G, Selvarajah D, Anton A, Teh K, Wilkinson ID & Tesfaye S (2023) Preservation of thalamic mitochondrial and neuronal function in Painful-Diabetic Peripheral Neuropathy: a multi-modal cerebral imaging study. DIABETOLOGIA, Vol. 66(SUPPL 1) (pp S106-S106)
Sloan GP, Selvarajah D, Teh K, Wilkinson ID & Tesfaye S (2022) Increased functional connectivity of the thalamus to the primary somatosensory cortex and insular cortex following treatment withdrawal: A potential biomarker of painful-diabetic peripheral neuropathy. DIABETIC MEDICINE, Vol. 39
Teh K, Mcallister J, Fan J, Anandhanarayanan A, Sloan G, Tesfaye S & Selvarajah D (2022) Better target engagement of opioid receptor systems in responders to neuropathic pain treatment: A resting-state functional magnetic resonance imaging study in painful diabetic neuropathy. DIABETIC MEDICINE, Vol. 39
Greig M, Sloan G, Shillo PR, Selvarajah D, Wilkinson ID & Tesfaye S (2022) Mood disorders are related to thalamic H¹-MRS metabolite parameters in type 1 diabetes. DIABETOLOGIA, Vol. 65(SUPPL 1) (pp S380-S381)
Selvarajah D, Teh K, Mcallister J, Anandhanarayanan A, Fan J, Sloan G & Tesfaye S (2022) Better target engagement of opioid receptor systems in responders to neuropathic pain treatment: a neurotransmitter-enriched functional connectivity mapping study. DIABETOLOGIA, Vol. 65(SUPPL 1) (pp S99-S99)
Sloan G, Selvarajah D, Teh K, Wilkinson I & Tesfaye S (2022) Increased functional connectivity of the Thalamus and primary Somatosensory cortex and insular cortex following treatment withdrawal: a potential biomarker of painful-DPN. DIABETOLOGIA, Vol. 65(SUPPL 1) (pp S99-S99)
Teh K, Mcallister J, Anandhanarayanan A, Fan J, Sloan G, Tesfaye S & Selvarajah D (2022) Identification of painful diabetic neuropathy subtypes from functional connectivity resting state MRI patterns: a novel data driven machine learning approach. DIABETOLOGIA, Vol. 65(SUPPL 1) (pp S380-S380)
Greig M, Sloan G, Shillo P, Selvarajah D, Wilkinson ID & Tesfaye S (2021) Pain processing areas of the brain demonstrate altered microvascular perfusion during spontaneous neuropathic pain. DIABETOLOGIA, Vol. 64(SUPPL 1) (pp 34-34)
Sloan G, Selvarajah D, Teh K, Greig M, Shillo P, Wilkinson ID & Tesfaye S (2021) Morphometric abnormalities of the brain in diabetic peripheral neuropathy. DIABETOLOGIA, Vol. 64(SUPPL 1) (pp 33-34)
Selvarajah D, Teh K, Wilkinson I, Heiberg-Gibbons F, Awadh M, Kelsall A, Sloan G & Tesfaye S (2021) A novel, multimodal magnetic resonance imaging and a machine learning approach to classifying sensory phenotypes in painful DPN. DIABETOLOGIA, Vol. 64(SUPPL 1) (pp 316-317)
Sloan G, Selvarajah D, Teh K, Shillo P, Greig M, Wilkinson ID & Tesfaye S (2021) Morphometric abnormalities in the brain in painless and painful diabetic peripheral neuropathy. DIABETIC MEDICINE, Vol. 38
Grieg MA, Sloan G, Pallai P, Selvarajah S, Wilkinson W & Tesfaye T (2021) Microvascular perfusion of the processing of the brain is altered during the experience of spontaneous neuropathic pain in diabetes. DIABETIC MEDICINE, Vol. 38
Teh K, Wilkinson ID, Heiberg-Gibbons F, Awadh M, Kelsall A, Pallai S, Sloan G, Tesfaye S & Selvarajah D (2021) Abnormal somatosensory cortex functional connectivity in painful diabetic neuropathy: Clues to the pathogenesis of different sensory clinical phenotypes of neuropathic pain: A novel, multimodal magnetic resonance imaging study. DIABETIC MEDICINE, Vol. 38
(2020) Basic and clinical science posters: New insulins, technology, therapies and treatment. Diabetic Medicine, Vol. 37(S1) (pp 56-56)
Sloan G, Lam K, Wright J & Selvarajah D (2020) The prevalence of incidental haematological conditions in patients with extremely low HbA1c levels (<20mmol/mol) identified through routine diabetes testing. DIABETIC MEDICINE, Vol. 37 (pp 141-141)
Wikinson ID, Teh K, Agrawal S, Kelsall A, Pallai S, Sloan G, Tesfaye S & Selvarajah D (2020) Predicting treatment response using magnetic resonance imaging in painful diabetic neuropathy. DIABETIC MEDICINE, Vol. 37 (pp 7-7)
Sloan G, Anton A, Selvarajah D, Wilkinson I & Tesfaye S (2020) Altered mitochondrial activity in the thalamus and somatosensory cortex in painful diabetic peripheral neuropathy. DIABETOLOGIA, Vol. 63(SUPPL 1) (pp S92-S92)
Khalifa M, Wright J, Sloan G, Selvarajah D & Lam K (2020) Low haemoglobin A1c (HbA1c) result: lessons learnt in clinical practice. BRITISH JOURNAL OF HAEMATOLOGY, Vol. 189 (pp 78-79)
Wilkinson I, Teh K, Heiberg-Gibbons F, Awadh M, Pallai S, Kelsall A, Sloan G, Tesfaye S & Selvarajah D (2019) Central brain mechanisms that predict treatment response in painful diabetic neuropathy. DIABETOLOGIA, Vol. 62 (pp S15-S16)
Selvarajah D, Teh K, Palai S, Sloan G, Tesfaye S & Wilkinson I (2019) Central pain signature for painful diabetic neuropathy (DN) derived from magnetic resonance imaging. DIABETOLOGIA, Vol. 62 (pp S17-S17)

Professional activities and memberships: Clinical Academic Trainee Representative: University of Sheffield Clinical Academic Working Group
Youth Committee Co-Ordinator: Diabetic Neuropathy Study Group (NEUROdiab)
Treasurer: Young Diabetologist and Endocrinologist Forum
Committee member: International Association for the Study of Pain, Neuropathic Pain Specialist Interest Group Subcommittee