Dr Daniel Taylor

MBChB, MRes

Clinical Medicine, School of Medicine and Population Health

Academic Clinical Fellow (Biomedical Research Centre)

daniel.taylor@sheffield.ac.uk

The Medical School

Full contact details

Dr Daniel Taylor
Clinical Medicine, School of Medicine and Population Health
The Medical School
Beech Hill Road
Sheffield
S10 2RX

Profile: I joined the University of Sheffield in 2020, whilst an undergraduate medical student, to study for a Master of Research in cardiovascular science. I graduated top of my year and was awarded the Cumberland Award. Through this time, I developed a research interest in computational modelling of blood flow and vascular morphometric scaling in the coronary arteries. I subsequently graduated from Lancaster Medical School in 2021, ranked first in my year, and was awarded the Medical School Academic Prize and Lancaster University Chancellor’s Medal. I completed the first stage of my postgraduate clinical training as a research-focused specialised foundation doctor at Sheffield Teaching Hospitals. I am currently working as a Sheffield BRC Academic Clinical Fellow at the University of Sheffield.

Research interests

I am a member of the Mathematical Modelling in Medicine research group within the Division of Clinical Medicine. My primary research interests are in computational modelling of blood flow and vascular morphometric scaling. Under the supervision of Dr Paul Morris and Professor Ian Halliday, I am involved in the ongoing development and validation of the VIRTUheart suite for computing coronary physiology. This is an image-based software which computes fractional flow reserve (FFR), absolute flow (mL/min) and microvascular resistance in the coronary arterial circulation. Current work particularly focuses on development of side branch flow techniques, in-vivo validation and tool clinical applicability.

I have also worked extensively on coronary morphometric scaling, which describes the relationship between arterial size and blood flow around bifurcation points. I recently published a meta-analysis on this subject, for which I was awarded the Sheffield School of Medicine and Population Health early career researcher prize. My other research interests include zero-dimensional modelling of global haemodynamics, which has recently been applied to modelling gravitational forces in commercial spaceflight and creating safer hospital systems.

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Taylor DJ, Saxton H, Halliday I, Newman T, Hose DR, Kassab GS, Gunn JP & Morris PD (2024) A systematic review and meta-analysis of Murray's Law in the coronary arterial circulation. American Journal of Physiology-Heart and Circulatory Physiology, 327(1), H182-H190. View this article in WRRO
Taylor DJ, Aubiniere-Robb L, Gosling R, Newman T, Hose DR, Halliday I, Lawford PV, Narracott AJ, Gunn JP & Morris PD (2023) Sex differences in coronary microvascular resistance measured by a computational fluid dynamics model. Frontiers in Cardiovascular Medicine, 10. View this article in WRRO
Taylor DJ, Feher J, Czechowicz K, Halliday I, Hose DR, Gosling R, Aubiniere-Robb L, van’t Veer M, Keulards DCJ, Tonino P , Rochette M et al (2023) Validation of a novel numerical model to predict regionalized blood flow in the coronary arteries. European Heart Journal - Digital Health, 4(2). View this article in WRRO
Taylor DJ & Goodwin D (2022) Organisational failure: rethinking whistleblowing for tomorrow’s doctors. Journal of Medical Ethics, 48(10), 672-677.
Aubiniere-Robb L, Gosling R, Taylor DJ, Newman T, Hose DR, Halliday I, Lawford PV, Narracott AJ, Gunn JP & Morris PD (2022) The complementary value of absolute coronary flow in the assessment of patients with ischaemic heart disease. Nature Cardiovascular Research, 1(7), 611-616. View this article in WRRO
Taylor DJ, Feher J, Halliday I, Hose DR, Gosling R, Aubiniere-Robb L, van ‘t Veer M, Keulards D, Tonino PAL, Rochette M , Gunn J et al (2022) Refining our understanding of the flow through coronary artery branches; revisiting Murray’s law in human epicardial coronary arteries. Frontiers in Materials, 13. View this article in WRRO
Morris PD, Anderton RA, Marshall-Goebel K, Britton JK, Lee SMC, Smith NP, van de Vosse FN, Ong KM, Newman TA, Taylor DJ , Chico T et al () Computational modelling of cardiovascular pathophysiology to risk stratify commercial spaceflight. Nature Reviews Cardiology.

All publications

Journal articles

Morris PD, Williams GJ, Taylor DJ, Al Baraikan A, Haley H, Ghobrial M, Gosling R, Newman TA, Wood DA, Cairns JA , Ramasundarahettige C et al (2024) Virtual physiological analysis of non-culprit disease in patients with STEMI and multivessel disease: a substudy of the COMPLETE trial. European Heart Journal, 45(Supplement_1). View this article in WRRO
Taylor DJ & Morris PD (2024) Letter to the editor. Medical Engineering and Physics, 130.
Taylor DJ, Saxton H, Halliday I, Newman T, Hose DR, Kassab GS, Gunn JP & Morris PD (2024) A systematic review and meta-analysis of Murray's Law in the coronary arterial circulation. American Journal of Physiology-Heart and Circulatory Physiology, 327(1), H182-H190. View this article in WRRO
Ghobrial M, Haley H, Gosling R, Taylor DJ, Richardson J, Morgan K, Barmby D, Iqbal J, Krishnamurthy A, Singh R , Conway D et al (2024) Modelled impact of virtual fractional flow reserve in patients undergoing coronary angiography (VIRTU-4). Heart. View this article in WRRO
Taylor DJ, Saxton H, Halliday I, Newman T, Feher J, Gosling R, Narracott AJ, van Kemenade D, van’t Veer M, Tonino PAL , Rochette M et al (2024) Evaluation of models of sequestration flow in coronary arteries—physiology versus anatomy?. Computers in Biology and Medicine, 173. View this article in WRRO
Taylor DJ & Morris PD (2024) Letter to the editor. Medical Engineering & Physics, 130, 104204-104204.
Taylor DJ, Aubiniere-Robb L, Gosling R, Newman T, Hose DR, Halliday I, Lawford PV, Narracott AJ, Gunn JP & Morris PD (2023) Sex differences in coronary microvascular resistance measured by a computational fluid dynamics model. Frontiers in Cardiovascular Medicine, 10. View this article in WRRO
Taylor DJ, Feher J, Czechowicz K, Halliday I, Hose DR, Gosling R, Aubiniere-Robb L, van’t Veer M, Keulards DCJ, Tonino P , Rochette M et al (2023) Validation of a novel numerical model to predict regionalized blood flow in the coronary arteries. European Heart Journal - Digital Health, 4(2). View this article in WRRO
Goodwin D & Taylor DJ (2022) Response to: Correspondence on ‘Organisational failure: rethinking whistleblowing for tomorrow’s doctors’ by Taylor and Goodwin. Journal of Medical Ethics, 48(11), 891-892.
Taylor DJ & Goodwin D (2022) Organisational failure: rethinking whistleblowing for tomorrow’s doctors. Journal of Medical Ethics, 48(10), 672-677.
Aubiniere-Robb L, Gosling R, Taylor DJ, Newman T, Hose DR, Halliday I, Lawford PV, Narracott AJ, Gunn JP & Morris PD (2022) The complementary value of absolute coronary flow in the assessment of patients with ischaemic heart disease. Nature Cardiovascular Research, 1(7), 611-616. View this article in WRRO
Taylor DJ, Feher J, Halliday I, Hose DR, Gosling R, Aubiniere-Robb L, van ‘t Veer M, Keulards D, Tonino PAL, Rochette M , Gunn J et al (2022) Refining our understanding of the flow through coronary artery branches; revisiting Murray’s law in human epicardial coronary arteries. Frontiers in Materials, 13. View this article in WRRO
Taylor D, Morris PD, Gunn J, Gosling R, Halliday I, Hose DR, Rammohan V, van‘t Veer M, Tonino PA, Keulards D , Feher J et al (2022) A novel predictive model of coronary arterial inlet, outlet and side-branch blood flow. Journal of the American College of Cardiology, 79(9), 2022. View this article in WRRO
Morris PD, Anderton RA, Marshall-Goebel K, Britton JK, Lee SMC, Smith NP, van de Vosse FN, Ong KM, Newman TA, Taylor DJ , Chico T et al () Computational modelling of cardiovascular pathophysiology to risk stratify commercial spaceflight. Nature Reviews Cardiology.

Chapters

Tlałka K, Saxton H, Halliday I, Xu X, Taylor D, Narracott A & Malawski M (2024) Local Sensitivity Analysis of a Closed-Loop in Silico Model of the Human Baroregulation, Computational Science – ICCS 2024 (pp. 173-187). Springer Nature Switzerland

Conference proceedings papers

Taylor D, Saxton H, Halliday I, Newman T, Kassab G, Gunn J & Morris P (2024) BS54 A systematic review and meta-analysis of murray’s law in the coronary arterial circulation. Basic science
Taylor D, Gunn J, Halliday I, Narracott A, Gosling R, Morris P, Newman T & Saxton H (2024) 220 Sensitivity of computed coronary physiology to murray’s law of vascular scaling. Stable IHD/Prevention/Hypertension/Lipids

Teaching interests: I enjoy teaching clinical skills to undergraduate medical students on the wards and in simulated settings and am currently completing the final stages of a post-graduate certificate in medical education. I also lecture on the Cardiovascular Medicine: From Molecules to Man MRes course at the University of Sheffield and have co-supervised student computational modelling projects.