Professor Colin D Bingle

Clinical Medicine, School of Medicine and Population Health

Professor of Respiratory Cell and Molecular Biology

Departmental Director of Research and Innovation

c.d.bingle@sheffield.ac.uk
+44 114 215 9514

+44 114 271 1863 (Fax)

The Medical School

Full contact details

Professor Colin D Bingle
Clinical Medicine, School of Medicine and Population Health
The Medical School
Beech Hill Road
Sheffield
S10 2RX

Profile: For enquiries please contact - SMPH-West-Operational@sheffield.ac.uk

I was promoted to Professor of Respiratory Cell and Molecular Biology at the University of Sheffield in 2016. I have been at Sheffield since 1997 when I was appointed to a Lectureship to support the development of molecular and cell biology within the Department of Medicine and Pharmacology.

My research has been focused on lung epithelial cell biology since I undertook a Postdoctoral Fellowship at Washington University in St Louis between 1991 and 1993. During that time I became interested in the molecular basis of cell type specific gene expression and I published the first ever paper that identified a specific functional role for a transcription factor (HNF-3α) in the regulation of a lung specific gene (Biochem J 1993;295:227-232). Since this time my work has continued to employ molecular biology techniques to address questions relating to the regulation, structure, expression and function of pulmonary epithelial genes.

Research interests

My long-standing research interests have been focused on cellular differentiation and regulation of gene expression within the developing and adult pulmonary epithelium. This work involves the isolation of pulmonary epithelial cell specific genes as well as the transcription factors, which regulate their expression.

My interests have expanded into the fields of the genetics of complex diseases, pulmonary immunology, innate immunity and host defence.

Current projects

My research projects largely focus on the identification and characterisation of novel innate immune regulators, particularly members of the WFDC (Oncogene 2002;21:2768-2773) and BPIF/PLUNC (Hum Mol Gen 2002;11:937-943) protein families. Indeed, we identified the later family of proteins and they have gone on to become a significant area of my research focus.

Latterly, I have become involved in studies designed to investigate the function and expression of these genes in the developing and diseased respiratory tract using a wide range of clinical samples and understanding the biology of these genes is a key focus of my work. My continuing studies in this area are designed to elucidate the role these proteins play in a range of pulmonary disease including chronic obstructive pulmonary disease (COPD), pulmonary fibrosis, cystic fibrosis (CF) and asthma in adults as well as in neonatal and paediatric diseases including RSV bronchiolitis and otitis media.

I have expanded my studies into the more tractable murine model systems with the aim of identifying the function of individual genes from these gene families.

My group works extensively with primary airway epithelial cells (both human and murine) in differentiated air liquid interface cultures as tools to understand the regulation of airway epithelial cell specific genes. This involves the respiratory epithelium in its’ very widest sense and we work with airway, nasal and middle ear cells. This work also now involves studies of salivary gland biology. At a more clinical level we also studye blurb host/pathogen interactions using both viral (Influenza A, RSV) and bacterial (Staphylococcus aureus and NTHi) infections. We are presently developing these models to understand the biology of co-infections as well as the role of inflammatory cells in this process.

This applied work has allowed me to continue to study the role of epithelial differentiation in the respiratory tract and to use disease models and our novel genes to study aspects of pulmonary cell plasticity in the respiratory tract. It has also led to new avenues of work on epithelial responses in nasopharyngeal infections and in otitis media and latterly to more applied studies on the biology of multiciliogenesis, an interest of mice since working with FOXJ1 as a post-doc in St Louis.

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Gui M, Farley H, Anujan P, Anderson JR, Maxwell DW, Whitchurch JB, Botsch JJ, Qiu T, Meleppattu S, Singh SK , Zhang Q et al (2021) De novo identification of mammalian ciliary motility proteins using cryo-EM. Cell.
Ziegler CGK, Allon SJ, Nyquist SK, Mbano IM, Miao VN, Tzouanas CN, Cao Y, Yousif AS, Bals J, Hauser BM , Feldman J et al (2020) SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues. Cell. View this article in WRRO
Lu H, Anujan P, Zhou F, Zhang Y, Chong YL, Bingle CD & Roy S (2019) Mcidas mutant mice reveal a two-step process for the specification and differentiation of multiciliated cells in mammals. Development, 146(6). View this article in WRRO
Mulay A, Hood DW, Williams D, Russell C, Brown SDM, Bingle L, Cheeseman M & Bingle CD (2018) Loss of the homeostatic protein BPIFA1, leads to exacerbation of otitis media severity in the Junbo mouse model. Scientific Reports, 8(1). View this article in WRRO
Akram K, Moyo N, Leeming G, Bingle L, Jasim S, Hussain S, Schorlemmer A, Kipar A, Digard P, Tripp R , Shohet V et al (2017) An innate defense peptide BPIFA1/SPLUNC1 restricts influenza A virus infection. Mucosal immunology, 11, 71-81. View this article in WRRO
Mulay A, Akram K, Williams D, Armes H, Russell C, Hood D, Armstrong S, Stewart JP, Brown SD, Bingle L & Bingle CD (2016) An in vitro model of murine middle ear epithelium.. Disease Models and Mechanisms, 9, 1405-1417. View this article in WRRO
Saferali A, Obeidat M, Bérubé J-C, Lamontagne M, Bossé Y, Laviolette M, Hao K, Nickle DC, Timens W, Sin DD , Postma DS et al (2015) Polymorphisms Associated with Expression of BPIFA1/BPIFB1 and Lung Disease Severity in Cystic Fibrosis. American Journal of Respiratory Cell and Molecular Biology, 53(5), 607-614.
Gao J, Ohlmeier S, Nieminen P, Toljamo T, Tiitinen S, Kanerva T, Bingle L, Araujo B, Rönty M, Höyhtyä M , Bingle CD et al (2015) Elevated sputum BPIFB1 levels in smokers with chronic obstructive pulmonary disease: a longitudinal study. American Journal of Physiology-Lung Cellular and Molecular Physiology, 309(1), L17-L26.
Leeming GH, Kipar A, Hughes DJ, Bingle L, Bennett E, Moyo NA, Tripp RA, Bigley AL, Bingle CD, Sample JT & Stewart JP (2015) Gammaherpesvirus infection modulates the temporal and spatial expression of SCGB1A1 (CCSP) and BPIFA1 (SPLUNC1) in the respiratory tract. Laboratory Investigation, 95(6), 610-624. View this article in WRRO
Bingle CD, Araujo B, Wallace WA, Hirani N & Bingle L (2013) What is top of the charts? BPIFB1/LPLUNC1 localises to the bronchiolised epithelium in the honeycomb cysts in UIP. Thorax, 68(12), 1167-1168.
Musa M, Wilson K, Sun L, Mulay A, Bingle L, Marriott HM, LeClair EE & Bingle CD (2012) Differential localisation of BPIFA1 (SPLUNC1) and BPIFB1 (LPLUNC1) in the nasal and oral cavities of mice.. Cell Tissue Res, 350(3), 455-464. View this article in WRRO
Bingle L, Wilson K, Musa M, Araujo B, Rassl D, Wallace WA, LeClair EE, Mauad T, Zhou Z, Mall MA & Bingle CD (2012) BPIFB1 (LPLUNC1) is upregulated in cystic fibrosis lung disease.. Histochem Cell Biol, 138(5), 749-758. View this article in WRRO
Bingle CD (2011) Towards defining the complement of mammalian WFDC-domain-containing proteins.. Biochem Soc Trans, 39(5), 1393-1397.
Shin OS, Uddin T, Citorik R, Wang JP, Della Pelle P, Kradin RL, Bingle CD, Bingle L, Camilli A, Bhuiyan TR , Shirin T et al (2011) LPLUNC1 modulates innate immune responses to Vibrio cholerae.. J Infect Dis, 204(9), 1349-1357.
Bingle CD, Seal RL & Craven CJ (2011) Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a subfamily of the BPI fold-containing superfamily.. Biochemical Society Transactions, 39(4), 977-983. View this article in WRRO
Bingle CD, Wilson K, Lunn H, Barnes FA, High AS, Wallace WA, Rassl D, Campos MA, Ribeiro M & Bingle L (2010) Human LPLUNC1 is a secreted product of goblet cells and minor glands of the respiratory and upper aerodigestive tracts.. Histochem Cell Biol, 133(5), 505-515. View this article in WRRO
Bingle L, Barnes FA, Lunn H, Musa M, Webster S, Douglas CWI, Cross SS, High AS & Bingle CD (2009) Characterisation and expression of SPLUNC2, the human orthologue of rodent parotid secretory protein.. Histochem Cell Biol, 132(3), 339-349. View this article in WRRO
Bingle L, Barnes FA, Cross SS, Rassl D, Wallace WA, Campos MA & Bingle CD (2007) Differential epithelial expression of the putative innate immune molecule SPLUNC1 in cystic fibrosis.. Respir Res, 8, 79. View this article in WRRO
Bingle L, Cross SS, High AS, Wallace WA, Rassl D, Yuan G, Hellstrom I, Campos MA & Bingle CD (2006) WFDC2 (HE4): a potential role in the innate immunity of the oral cavity and respiratory tract and the development of adenocarcinomas of the lung.. Respir Res, 7, 61. View this article in WRRO
Bingle CD & Craven CJ (2002) PLUNC: a novel family of candidate host defence proteins expressed in the upper airways and nasopharynx.. Hum Mol Genet, 11(8), 937-943.

All publications

Journal articles

Bingle C (2024) Careers and research culture. The Biochemist, 46(4), 1-2.
Pérez-de-Oliveira ME, Wagner VP, Bingle CD, Vargas PA & Bingle L (2024) Disruption of oncogenic pathways in mucoepidermoid carcinoma: CREB inhibitor 666.15 as a potential therapeutic agent. Oral Oncology, 159, 107029-107029.
Vargas PPA, Pérez-de-Oliveira DME, Wagner DVP, Bingle PCD & Bingle PL (2024) Effects of CREB inhibitor in mucoepidermoid carcinoma cell lines. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 138(2), e45-e45.
Bingle C (2024) Science and art. The Biochemist, 46(3), 1-2.
PÉREZ-DE-OLIVEIRA ME, WAGNER VP, BINGLE CD, VARGAS PA & BINGLE L (2024) CREB INHIBITOR THERAPY FOR MUCOEPIDERMOID CARCINOMA.. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 137(6), e291-e291.
Bingle CD (2024) Artificial intelligence. The Biochemist, 46(2), 1-2.
Bingle C (2024) Psychedelic therapies. The Biochemist, 46(1), 1-2.
Dudchenko O, Ordovas-Montanes J & Bingle CD (2023) Respiratory epithelial cell types, states and fates in the era of single-cell RNA-sequencing. Biochemical Journal, 480(13), 921-939.
Wagner VP, Ferrarotto R, Vargas PA, Martins MD, Bingle CD & Bingle L (2023) Drug-based therapy for advanced adenoid cystic carcinoma: Current landscape and challenges based on an overview of registered clinical trials. Critical Reviews in Oncology/Hematology, 181, 103886-103886.
Wagner VP, Bingle CD & Bingle L (2022) MYB-NFIB fusion transcript in Adenoid Cystic Carcinoma: current state of knowledge and future directions. Critical Reviews in Oncology/Hematology, 103745-103745.
Costa-Martins AG, Mane K, Lindsey BB, Ogava RLT, Castro IC, Jagne YJ, Sallah HJ, Armitage EP, Jarju S, Ahadzie B , Ellis-Watson R et al (2022) Prior upregulation of interferon pathways in the nasopharynx impacts viral shedding following live attenuated influenza vaccine challenge in children. Cell Reports Medicine, 3(2), 100516-100516.
Costa-Martins AG, Mane K, Lindsey BB, Ogava RLT, Castro Í, Jagne YJ, Sallah HJ, Armitage EP, Jarju S, Ahadzie B , Ellis-Watson R et al (2021) Prior upregulation of interferon pathways in the nasopharynx impacts viral shedding following live attenuated influenza vaccine challenge in children. Cell Reports Medicine, 2(12).
Bingle CD & Bingle L (2021) SPLUNC1 comes of age? Predicting acute exacerbations in cystic fibrosis. European Respiratory Journal, 58(5), 2101569-2101569.
Gui M, Farley H, Anujan P, Anderson JR, Maxwell DW, Whitchurch JB, Botsch JJ, Qiu T, Meleppattu S, Singh SK , Zhang Q et al (2021) De novo identification of mammalian ciliary motility proteins using cryo-EM. Cell.
Mather MW, Verdon B, Botting RA, Engelbert J, Delpiano L, Xu X, Hatton C, Davey T, Lisgo S, Yates P , Dawe N et al (2021) Development of a physiological model of human middle ear epithelium. Laryngoscope Investigative Otolaryngology. View this article in WRRO
Mather MW, Powell S, Talks B, Ward C, Bingle CD, Haniffa M & Powell J (2021) Dysregulation of immune response in otitis media. Expert Reviews in Molecular Medicine, 23.
Amoura EB, Hunter KD, Bingle CD & Bingle LB (2021) IN SITU DETECTION OF CRTC-MAML2 TRANSLOCATION EXPRESSION IN MUCOEPIDERMOID CARCINOMA. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 132(1), e6-e7.
Mulay A, Chowdhury M, James C, Bingle L & Bingle C (2021) The transcriptional landscape of the cultured murine middle ear epithelium in vitro. Biology Open, 10(4).
Innocentini LMAR, Silva AA, Carvalho MA, Coletta RD, Pizzigatti Corrêa ME, Bingle L, Bingle CD, Vargas PA & Lopes MA (2021) Salivary BPIFA proteins are altered in patients undergoing hematopoietic cell transplantation. Oral Diseases. View this article in WRRO
Wagner VP, Martins MD, Amoura E, Zanella VG, Roesler R, de Farias CB, Bingle CD, Vargas PA & Bingle L (2020) TrkB-targeted therapy for mucoepidermoid carcinoma. Biomedicines, 8(12). View this article in WRRO
Ziegler CGK, Allon SJ, Nyquist SK, Mbano IM, Miao VN, Tzouanas CN, Cao Y, Yousif AS, Bals J, Hauser BM , Feldman J et al (2020) SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues. Cell. View this article in WRRO
PEREIRA DL, BINGLE L, BINGLE CD, PIRES FR, LOPES MA & VARGAS PA (2020) EVALUATION OF HE4 AND SLPI EXPRESSION IN INTRAORAL MUCOEPIDERMOID CARCINOMAS. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 129(1), e152-e152.
Lu H, Anujan P, Zhou F, Zhang Y, Chong YL, Bingle CD & Roy S (2019) Mcidas mutant mice reveal a two-step process for the specification and differentiation of multiciliated cells in mammals. Development, 146(6). View this article in WRRO
Preston JA, Bewley MA, Marriott HM, Houghton AM, Mohasin M, Jubrail J, Morris L, Stephenson YL, Cross S, Greaves DR , Craig RW et al (2019) Alveolar Macrophage Apoptosis-Associated Bacterial Killing Helps Prevent Murine Pneumonia.. American Journal of Respiratory and Critical Care Medicine. View this article in WRRO
De Smet EG, Seys LJM, Verhamme FM, Vanaudenaerde BM, Brusselle GG, Bingle CD & Bracke KR (2018) Association of innate defense proteins BPIFA1 and BPIFB1 with disease severity in COPD. International Journal of COPD, 13, 11-27. View this article in WRRO
Pereira DL, Bingle L, Bingle CD, Lopes MA & Vargas PA (2018) Expression of BPIF/PLUNC Protein Family and MECT1-MAML2 Fusion in Salivary Mucoepidermoid Carcinomas: a Preliminary Study. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 126(3), e158-e158.
Akram KM, Moyo NA, Leeming GH, Bingle L, Jasim S, Hussain S, Schorlemmer A, Kipar A, Digard P, Tripp RA , Shohet RV et al (2018) Erratum: An innate defense peptide BPIFA1/SPLUNC1 restricts influenza A virus infection. Mucosal Immunology, 11(3), 1008-1008.
Mulay A, Hood DW, Williams D, Russell C, Brown SDM, Bingle L, Cheeseman M & Bingle CD (2018) Loss of the homeostatic protein BPIFA1, leads to exacerbation of otitis media severity in the Junbo mouse model. Scientific Reports, 8(1). View this article in WRRO
Qiu Q, Peng Y, Zhu Z, Chen Z, Zhang C, Ong HH, Tan KS, Hong H, Yan Y, Huang H , Liu J et al (2018) Absence or mislocalization of DNAH5 is a characteristic marker for motile ciliary abnormality in nasal polyps. The Laryngoscope, 128(3), E97-E104.
Akram K, Moyo N, Leeming G, Bingle L, Jasim S, Hussain S, Schorlemmer A, Kipar A, Digard P, Tripp R , Shohet V et al (2017) An innate defense peptide BPIFA1/SPLUNC1 restricts influenza A virus infection. Mucosal immunology, 11, 71-81. View this article in WRRO
Alves DBM, Bingle L, Bingle CD, Lourenco SV, Silva AA, Pereira DL & Vargas PA (2017) BPI-fold (BPIF) containing/plunc protein expression in human fetal major and minor salivary glands. Brazilian Oral Research, 31. View this article in WRRO
Mulay A, Akram K, Williams D, Armes H, Russell C, Hood D, Armstrong S, Stewart JP, Brown SD, Bingle L & Bingle CD (2016) An in vitro model of murine middle ear epithelium.. Disease Models and Mechanisms, 9, 1405-1417. View this article in WRRO
Ugonna K, Douros K, Bingle CD & Everard ML (2016) Cytokine responses in primary and secondary respiratory syncytial virus infections. Pediatric Research, 79, 946-950.
Leeming GH, Moyo N, Akram K, Tompkins M, Chapman G, Walsh T, Bingle L, Bingle C, Tripp R & Stewart JP (2016) BPIFA1: A Protein with an Important Role in the Inflammatory Response to Viral Infection in the Respiratory Tract. Journal of Comparative Pathology, 154(1), 76-76.
Saferali A, Obeidat M, Bérubé J-C, Lamontagne M, Bossé Y, Laviolette M, Hao K, Nickle DC, Timens W, Sin DD , Postma DS et al (2015) Polymorphisms Associated with Expression of BPIFA1/BPIFB1 and Lung Disease Severity in Cystic Fibrosis. American Journal of Respiratory Cell and Molecular Biology, 53(5), 607-614.
Gao J, Ohlmeier S, Nieminen P, Toljamo T, Tiitinen S, Kanerva T, Bingle L, Araujo B, Rönty M, Höyhtyä M , Bingle CD et al (2015) Elevated sputum BPIFB1 levels in smokers with chronic obstructive pulmonary disease: a longitudinal study. American Journal of Physiology-Lung Cellular and Molecular Physiology, 309(1), L17-L26.
Leeming GH, Kipar A, Hughes DJ, Bingle L, Bennett E, Moyo NA, Tripp RA, Bigley AL, Bingle CD, Sample JT & Stewart JP (2015) Gammaherpesvirus infection modulates the temporal and spatial expression of SCGB1A1 (CCSP) and BPIFA1 (SPLUNC1) in the respiratory tract. Laboratory Investigation, 95(6), 610-624. View this article in WRRO
Ugonna K, Bingle CD, Plant K, Wilson K & Everard ML (2014) Macrophages are required for dendritic cell uptake of respiratory syncytial virus from an infected epithelium.. PLoS One, 9(3), e91855. View this article in WRRO
Bingle CD, Araujo B, Wallace WA, Hirani N & Bingle L (2013) What is top of the charts? BPIFB1/LPLUNC1 localises to the bronchiolised epithelium in the honeycomb cysts in UIP. Thorax, 68(12), 1167-1168.
Dean C, Bingle C & Hind M (2013) Delivering and phenotyping mouse models for the respiratory community: a report on the Biochemical Society Workshop.. Clin Sci (Lond), 125(10), 495-500.
Bingle CD, Araujo B, Wallace WA, Hirani N & Bingle L (2013) What is top of the charts? BPIFB1/LPLUNC1 localises to the bronchiolised epithelium in the honeycomb cysts in UIP.. Thorax, 68(12), 1167-1168.
Taylor R, Bingle L & Bingle C (2013) Transcriptional analysis of the human BPIFA1/SPLUNC1 gene. EUROPEAN RESPIRATORY JOURNAL, 42.
Musa M, Wilson K, Sun L, Mulay A, Bingle L, Marriott HM, LeClair EE & Bingle CD (2012) Differential localisation of BPIFA1 (SPLUNC1) and BPIFB1 (LPLUNC1) in the nasal and oral cavities of mice.. Cell Tissue Res, 350(3), 455-464. View this article in WRRO
Bingle L, Wilson K, Musa M, Araujo B, Rassl D, Wallace WA, LeClair EE, Mauad T, Zhou Z, Mall MA & Bingle CD (2012) BPIFB1 (LPLUNC1) is upregulated in cystic fibrosis lung disease.. Histochem Cell Biol, 138(5), 749-758. View this article in WRRO
Leeming G, Stewart J, Hughes D, Bingle L, Bingle C & Kipar A (2012) EXPRESSION OF CCSP AND SPLUNC1, PUTATIVE ANTI-INFLAMMATORY PROTEINS, FOLLOWING MURINE RESPIRATORY VIRAL INFECTION IN VIVO. JOURNAL OF COMPARATIVE PATHOLOGY, 146(1), 49-49.
Bingle CD (2011) Towards defining the complement of mammalian WFDC-domain-containing proteins.. Biochem Soc Trans, 39(5), 1393-1397.
Shin OS, Uddin T, Citorik R, Wang JP, Della Pelle P, Kradin RL, Bingle CD, Bingle L, Camilli A, Bhuiyan TR , Shirin T et al (2011) LPLUNC1 modulates innate immune responses to Vibrio cholerae.. J Infect Dis, 204(9), 1349-1357.
Bingle L & Bingle CD (2011) Distribution of human PLUNC/BPI fold-containing (BPIF) proteins.. Biochem Soc Trans, 39(4), 1023-1027.
Bingle CD, Bingle L & Craven CJ (2011) Distant cousins: genomic and sequence diversity within the BPI fold-containing (BPIF)/PLUNC protein family.. Biochem Soc Trans, 39(4), 961-965.
Bingle CD, Seal RL & Craven CJ (2011) Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a subfamily of the BPI fold-containing superfamily.. Biochemical Society Transactions, 39(4), 977-983. View this article in WRRO
Bingle CD (2011) MUCking about in IPF: identification of a novel goblet cell phenotype in pulmonary fibrosis.. Thorax, 66(8), 647-648.
Chiang SC, Veldhuizen EJA, Barnes FA, Craven CJ, Haagsman HP & Bingle CD (2011) Identification and characterisation of the BPI/LBP/PLUNC-like gene repertoire in chickens reveals the absence of a LBP gene. Developmental and Comparative Immunology, 35(3), 285-295.
Wardle DJ, Burgon J, Sabroe I, Bingle CD, Whyte MKB & Renshaw SA (2011) Effective caspase inhibition blocks neutrophil apoptosis and reveals Mcl-1 as both a regulator and a target of neutrophil caspase activation.. PLoS One, 6(1), e15768. View this article in WRRO
Chiang S-C, Veldhuizen EJA, Barnes FA, Craven CJ, Haagsman HP & Bingle CD (2011) Identification and characterisation of the BPI/LBP/PLUNC-like gene repertoire in chickens reveals the absence of a LBP gene.. Dev Comp Immunol, 35(3), 285-295.
da Silva AA, Bingle L, Speight PM, Bingle CD, Mauad T, da Silva LFF & Vargas PA (2011) PLUNC protein expression in major salivary glands of HIV-infected patients.. Oral Dis, 17(3), 258-264.
Waby JS, Chirakkal H, Yu C, Griffiths GJ, Benson RSP, Bingle CD & Corfe BM (2010) Sp1 acetylation is associated with loss of DNA binding at promoters associated with cell cycle arrest and cell death in a colon cell line.. Mol Cancer, 9, 275. View this article in WRRO
Bingle CD, Wilson K, Lunn H, Barnes FA, High AS, Wallace WA, Rassl D, Campos MA, Ribeiro M & Bingle L (2010) Human LPLUNC1 is a secreted product of goblet cells and minor glands of the respiratory and upper aerodigestive tracts.. Histochem Cell Biol, 133(5), 505-515. View this article in WRRO
Bingle CD, Wilson K, Lunn H, Barnes FA, High AS, Wallace WA, Rassl D, Campos MA, Ribeiro M & Bingle L (2010) Human LPLUNC1 is a secreted product of goblet cells and minor glands of the respiratory and upper aerodigestive tracts. Histochemistry and Cell Biology, 1-11.
Bingle L, Barnes FA, Lunn H, Musa M, Webster S, Douglas CWI, Cross SS, High AS & Bingle CD (2009) Characterisation and expression of SPLUNC2, the human orthologue of rodent parotid secretory protein.. Histochem Cell Biol, 132(3), 339-349. View this article in WRRO
Vargas PA, Speight PM, Bingle CD, Barrett AW & Bingle L (2008) Expression of PLUNC family members in benign and malignant salivary gland tumours.. Oral Dis, 14(7), 613-619.
Bingle CD & Vyakarnam A (2008) Novel innate immune functions of the whey acidic protein family.. Trends Immunol, 29(9), 444-453.
Barnes FA, Bingle L & Bingle CD (2008) Pulmonary Genomics, Proteomics, and PLUNCs.. Am J Respir Cell Mol Biol, 38(4), 377-379.
Waby JS, Bingle CD & Corfe BM (2008) Post-translational control of sp-family transcription factors.. Curr Genomics, 9(5), 301-311. View this article in WRRO
Vaughan KR, Stokes L, Prince LR, Marriott HM, Meis S, Kassack MU, Bingle CD, Sabroe I, Surprenant A & Whyte MKB (2007) Inhibition of neutrophil apoptosis by ATP is mediated by the P2Y11 receptor.. J Immunol, 179(12), 8544-8553.
Bingle L, Barnes FA, Cross SS, Rassl D, Wallace WA, Campos MA & Bingle CD (2007) Differential epithelial expression of the putative innate immune molecule SPLUNC1 in cystic fibrosis.. Respir Res, 8, 79. View this article in WRRO
Wheeler TT, Hood KA, Maqbool NJ, McEwan JC, Bingle CD & Zhao S (2007) Expansion of the Bactericidal/Permeability Increasing-like (BPI-like) protein locus in cattle.. BMC Genomics, 8, 75. View this article in WRRO
Chen HM, Wilkins LM, Aziz N, Cannings C, Wyllie DH, Bingle C, Rogus J, Beck JD, Offenbacher S, Cork MJ , Rafie-Kolpin M et al (2006) Single nucleotide polymorphisms in the human interleukin-1B gene affect transcription according to haplotype context. HUM MOL GENET, 15(4), 519-529.
Bingle L, Cross SS, High AS, Wallace WA, Rassl D, Yuan G, Hellstrom I, Campos MA & Bingle CD (2006) WFDC2 (HE4): a potential role in the innate immunity of the oral cavity and respiratory tract and the development of adenocarcinomas of the lung.. Respir Res, 7, 61. View this article in WRRO
Dempsey CE, Dive C, Fletcher DJ, Barnes FA, Lobo A, Bingle CD, Whyte MKB & Renshaw SA (2005) Expression of pro-apoptotic Bfk isoforms reduces during malignant transformation in the human gastrointestinal tract.. FEBS Lett, 579(17), 3646-3650.
Bingle L, Cross SS, High AS, Wallace WA, Devine DA, Havard S, Campos MA & Bingle CD (2005) SPLUNC1 (PLUNC) is expressed in glandular tissues of the respiratory tract and in lung tumours with a glandular phenotype.. J Pathol, 205(4), 491-497.
Marriott HM, Bingle CD, Read RC, Braley KE, Kroemer G, Hellewell PG, Craig RW, Whyte MKB & Dockrell DH (2005) Dynamic changes in Mcl-1 expression regulate macrophage viability or commitment to apoptosis during bacterial clearance.. J Clin Invest, 115(2), 359-368. View this article in WRRO
Geetha C, Venkatesh SG, Bingle L, Bingle CD & Gorr S-U (2005) Design and validation of anti-inflammatory peptides from human parotid secretory protein.. J Dent Res, 84(2), 149-153.
Marriott HM, Bingle CD, Read RC, Braley KE, Kroemer G, Hellewell PG, Craig RW, Whyte MKB & Dockrell DH (2005) Dynamic changes in Mcl-1 expression regulate macrophage viability or commitment to apoptosis during bacterial clearance. Journal of Clinical Investigation, 115(2), 359-368.
Bingle CD & Gorr S-U (2004) Host defense in oral and airway epithelia: chromosome 20 contributes a new protein family.. Int J Biochem Cell Biol, 36(11), 2144-2152.
LeClair EE, Nomellini V, Bahena M, Singleton V, Bingle L, Craven CJ & Bingle CD (2004) Cloning and expression of a mouse member of the PLUNC protein family exclusively expressed in tongue epithelium.. Genomics, 83(4), 658-666.
Bingle CD & Craven CJ (2004) Meet the relatives: a family of BPI- and LBP-related proteins.. Trends Immunol, 25(2), 53-55.
Bingle CD, LeClair EE, Havard S, Bingle L, Gillingham P & Craven CJ (2004) Phylogenetic and evolutionary analysis of the PLUNC gene family.. Protein Sci, 13(2), 422-430.
Renshaw SA, Dempsey CE, Barnes FA, Bagstaff SM, Dower SK, Bingle CD & Whyte MKB (2004) Three novel Bid proteins generated by alternative splicing of the human Bid gene.. J Biol Chem, 279(4), 2846-2855.
Bingle CD & Craven CJ (2003) Comparative analysis of the PLUNC (palate, lung and nasal epithelium clone) protein families.. Biochem Soc Trans, 31(Pt 4), 806-809.
Renshaw SA, Parmar JS, Singleton V, Rowe SJ, Dower SK, Dockrell DH, Bingle CD, Chilvers ER & Whyte MKB (2003) Acceleration of Human Neutrophil Apoptosis by Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL). Clinical Science, 104(s49), 58P-58P.
Renshaw SA, Parmar JS, Singleton V, Rowe SJ, Dockrell DH, Dower SK, Bingle CD, Chilvers ER & Whyte MKB (2003) Acceleration of human neutrophil apoptosis by TRAIL.. J Immunol, 170(2), 1027-1033. View this article in WRRO
Renshaw SA, Bingle CD & Whyte MKB (2002) Identification and Characterisation of 3 Novel Bid Isoforms. Clinical Science, 103(s47), 54P-54P.
Vachon E, Bourbonnais Y, Bingle CD, Rowe SJ, Janelle MF & Tremblay GM (2002) Anti-inflammatory effect of pre-elafin in lipopolysaccharide-induced acute lung inflammation.. Biol Chem, 383(7-8), 1249-1256.
Bingle L, Singleton V & Bingle CD (2002) The putative ovarian tumour marker gene HE4 (WFDC2), is expressed in normal tissues and undergoes complex alternative splicing to yield multiple protein isoforms.. Oncogene, 21(17), 2768-2773.
Bingle CD & Craven CJ (2002) PLUNC: a novel family of candidate host defence proteins expressed in the upper airways and nasopharynx.. Hum Mol Genet, 11(8), 937-943.
Usher LR, Lawson RA, Geary I, Taylor CJ, Bingle CD, Taylor GW & Whyte MKB (2002) Induction of neutrophil apoptosis by the Pseudomonas aeruginosa exotoxin pyocyanin: a potential mechanism of persistent infection.. J Immunol, 168(4), 1861-1868. View this article in WRRO
Bingle CD, Singleton V & Bingle L (2002) HE4, an alternatively spliced WAP domain containing protein may contribute to host defence. Biochemical Society Transactions, 30(1), A38-A38.
Renshaw SA, Bingle CD & Whyte MKB (2001) Expression and Function of Novel Isoforms of the Apoptosis Regulating Protein, Bid, in Human Neutrophils. Clinical Science, 101(s45), 2P-2P.
Bingle L, Tetley TD & Bingle CD (2001) Cytokine-mediated induction of the human elafin gene in pulmonary epithelial cells is regulated by nuclear factor-kappaB.. Am J Respir Cell Mol Biol, 25(1), 84-91.
LeClair EE, Nguyen L, Bingle L, MacGowan A, Singleton V, Ward SJ & Bingle CD (2001) Genomic organization of the mouse plunc gene and expression in the developing airways and thymus.. Biochem Biophys Res Commun, 284(3), 792-797.
Bingle CD & Bingle L (2000) Characterisation of the human plunc gene, a gene product with an upper airways and nasopharyngeal restricted expression pattern.. Biochim Biophys Acta, 1493(3), 363-367.
Bingle CD, Craig RW, Swales BM, Singleton V, Zhou P & Whyte MK (2000) Exon skipping in Mcl-1 results in a bcl-2 homology domain 3 only gene product that promotes cell death.. J Biol Chem, 275(29), 22136-22146.
Renshaw SA, Timmons SJ, Eaton V, Usher LR, Akil M, Bingle CD & Whyte MK (2000) Inflammatory neutrophils retain susceptibility to apoptosis mediated via the Fas death receptor.. J Leukoc Biol, 67(5), 662-668.
Meléndez J, Maldonado V, Bingle CD, Selman M & Pardo A (2000) Cloning and expression of guinea pig TIMP-2. Expression in normal and hyperoxic lung injury.. Am J Physiol Lung Cell Mol Physiol, 278(4), L737-L743.
Whitehouse JL, Lee YC, Bingle CD, Antoniou M & Santis G (2000) Transcriptional regulation of thyroid transcription factor-1 (TTF-1) (vol 93, pg A 14, 1999). RESP MED, 94(3), 295-295.
Whyte M, Hubbard R, Meliconi R, Whidborne M, Eaton V, Bingle C, Timms J, Duff G, Facchini A, Pacilli A , Fabbri M et al (2000) Increased risk of fibrosing alveolitis associated with interleukin-1 receptor antagonist and tumor necrosis factor-α gene polymorphisms. American Journal of Respiratory and Critical Care Medicine, 162(2 I), 755-758.
Baines DL, Folkesson HG, Norlin A, Bingle CD, Yuan HT & Olver RE (2000) The influence of mode of delivery, hormonal status and postnatal O2 environment on epithelial sodium channel (ENaC) expression in perinatal guinea-pig lung.. J Physiol, 522 Pt 1, 147-157.
Whyte M, Renshaw S, Lawson R & Bingle C (1999) Apoptosis and the regulation of neutrophil lifespan.. Biochem Soc Trans, 27(6), 802-807.
Whyte M, Bingle C, Renshaw S & Lawson R (1999) Mechanisms of Neutrophil Apoptosis and the Regulation of Inflammation. Biochemical Society Transactions, 27(5), A134-A134.
Whyte M, Hubbard R, Meliconi R, Whidhorne M, Timms J, Wheatley A, Eaton V, Bingle C, Duff GW, Fabbri M , Facchini A et al (1999) Association of an interleukin-1 receptor antagonist polymorphism with idiopathic pulmonary fibrosis. AM J RESP CRIT CARE, 159(3), A504-A504.
Bingle CD (1999) Molecular cloning and expression of human HNF-3 beta.. AM J RESP CRIT CARE, 159(3), A728-A728.
Lee YC, Whitehouse JL, Santis G, Bingle CD & Antoniou M (1999) DNAse 1 hypersensitive sites of TTF-1 gene. AM J RESP CRIT CARE, 159(3), A445-A445.
Bingle CD (1999) Cloning of human fkh-5: Identification of a SCLC line as an abundant expressor of a neuronally restricted HNF-3/forkhead transcription factor.. AM J RESP CRIT CARE, 159(3), A727-A727.
Witherden IR, Goldstraw P, Ladas G, Ratcliffe C, Bingle CD & Tetley TD (1999) Expression of secretory leukoprotease inhibitor (SLPI) and elafin by primary human alveolar type II pneumocytes (TII) in vitro.. AM J RESP CRIT CARE, 159(3), A193-A193.
Downey JS, Bingle CD, Cottrell S, Ward N, Churchman D, Dobrota M & Powell CJ (1998) The LEC rat possesses reduced hepatic selenium, contributing to the severity of spontaneous hepatitis and sensitivity to carcinogenesis.. Biochem Biophys Res Commun, 244(2), 463-467.
Bingle CD (1997) Thyroid transcription factor-1.. Int J Biochem Cell Biol, 29(12), 1471-1473.
Yuan HT, Gowan S, Kelly FJ & Bingle CD (1997) Cloning of guinea pig surfactant protein A defines a distinct cellular distribution pattern within the lung. AM J PHYSIOL-LUNG C, 17(4), L900-L906.
Yuan HT, Gowan S, Kelly FJ & Bingle CD (1997) Cloning of guinea pig surfactant protein A defines a distinct cellular distribution pattern within the lung.. Am J Physiol, 273(4), L900-L906.
Gowan S, Toonen R & Bingle CD (1997) Human thyroid transcription factor-1. Functional characterization of the protein and analysis of protein/DNA interactions on the minimal promoter region.. Chest, 111(6 Suppl), 88S.
Baines DL, Bingle CD, Yuan H, Kemp PJ & Olver RE (1997) The fetal guinea-pig lung, near term, displays a rise in alpha ENaC mRNA expression that is independent of labour. J PHYSIOL-LONDON, 501P, P63-P64.
Bingle CD & Gowan S (1996) Oct-1 interacts with conserved motifs in the human thyroid transcription factor 1 gene minimal promoter.. Biochem J, 319 ( Pt 3), 669-674.
Bingle CD (1996) Generation of a rat bronchiolar epithelial cell cDNA library: isolation of a proline rich protein highly enriched in bronchiolar epithelial cells.. Biochem Biophys Res Commun, 225(3), 877-882.
Bingle CD & Gowan S (1996) Molecular cloning of the forkhead transcription factor HNF-3 alpha from a human pulmonary adenocarcinoma cell line.. Biochim Biophys Acta, 1307(1), 17-20.
Toonen RF, Gowan S & Bingle CD (1996) The lung enriched transcription factor TTF-1 and the ubiquitously expressed proteins Sp1 and Sp3 interact with elements located in the minimal promoter of the rat Clara cell secretory protein gene.. Biochem J, 316 ( Pt 2), 467-473.
Yuan HT, Bingle CD & Kelly FJ (1996) Differential patterns of antioxidant enzyme mRNA expression in guinea pig lung and liver during development.. Biochim Biophys Acta, 1305(3), 163-171.
Hackett BP, Bingle CD & Gitlin JD (1996) Mechanisms of gene expression and cell fate determination in the developing pulmonary epithelium.. Annu Rev Physiol, 58, 51-71.
YUAN HT, BINGLE CD & KELLY FJ (1995) BALR YOUNG INVESTIGATOR COMPETITION. RESP MED, 89(10), 723-750.
Bingle CD, Hackett BP, Moxley M, Longmore W & Gitlin JD (1995) Role of hepatocyte nuclear factor-3 alpha and hepatocyte nuclear factor-3 beta in Clara cell secretory protein gene expression in the bronchiolar epithelium.. Biochem J, 308 ( Pt 1), 197-202.
Bingle CD (1994) The regulation and role of caeruloplasmin expression in the lung. Respiratory Medicine, 88(10), 804-805.
Bingle CD & Gitlin JD (1993) Identification of hepatocyte nuclear factor-3 binding sites in the Clara cell secretory protein gene.. Biochem J, 295 ( Pt 1), 227-232.
Bingle CD, Fleming RE & Gitlin JD (1993) Interaction of CCAAT/enhancer-binding protein alpha and beta with the rat caeruloplasmin gene promoter.. Biochem J, 294 ( Pt 2), 473-479.
Haris PI, Chowrimootoo G, Bingle C, Chapman D & Srai KS (1993) Structural characterisation of human caeruloplasmin in solution by FTIR spectroscopy.. Biochem Soc Trans, 21(2), 175S.
BINGLE CD & GITLIN JD (1992) ROLE OF HEPATOCYTE NUCLEAR FACTOR-3-ALPHA IN CLARA CELL SPECIFIC GENE-EXPRESSION. MOL BIOL CELL, 3, A204-A204.
Bingle CD, Kelly F, Epstein O & Srai SK (1992) Induction of hepatic and pulmonary caeruloplasmin gene expression in developing guinea pigs following premature delivery.. Biochim Biophys Acta, 1139(3), 217-221.
Bingle CD, Srai SK & Epstein O (1992) Copper metabolism in hypercupremic human livers. Studies of its subcellular distribution, association with binding proteins and expression of mRNAs.. J Hepatol, 15(1-2), 94-101.
Bingle C, Ghazi S, Owen JS & Srai SK (1991) LCAT mRNA in liver disease.. Lancet, 338(8781), 1531.
Bingle CD, Epstein O, Srai SK & Gitlin JD (1991) Hepatic caeruloplasmin-gene expression during development in the guinea-pig. Correlation with changes in hepatic copper metabolism.. Biochem J, 276 ( Pt 3), 771-775.
Bingle CD, Srai SKS & Epstein O (1991) Transcription of copper protein mRNAs in diseased humanliver:Lack of correlation with hepatic copper levels. Journal of Hepatology, 13, S11-S11.
BINGLE CD, GITLIN JD, EPSTEIN O & SRAI SKS (1990) TRANSCRIPTIONAL REGULATION OF CERULOPLASMIN GENE-EXPRESSION IN THE DEVELOPING GUINEA-PIG LIVER. HEPATOLOGY, 12(4), 948-948.
BINGLE CD, SRAI SKS & EPSTEIN O (1990) HEPATIC COPPER DISTRIBUTION IN WILSONS-DISEASE AND HEPATIC COPPER OVERLOAD. GUT, 31(10), A1213-A1213.
BINGLE CD, SRAI SKS & EPSTEIN O (1990) COPPER DISTRIBUTION IN WILSONS-DISEASE AND HEPATIC COPPER OVERLOAD - STUDIES OF ITS SUBCELLULAR-DISTRIBUTION AND ASSOCIATION WITH COPPER PROTEINS. HEPATOLOGY, 12(4), 927-927.
Bingle CD, Epstein O & Srai SK (1990) A developmental shift from low- to high-Mr copper binders in guinea-pig serum.. Biochem Soc Trans, 18(4), 645.
Bingle CD, Srai SK & Epstein O (1990) Developmental changes in hepatic copper proteins in the guinea pig.. J Hepatol, 10(2), 138-143.
Bingle C, Srai K & Epstein O (1990) Hepatic Copper Distribution in Wilson's Disease and Primary Sclerosing Cholangitis. Clinical Science, 78(s22), 21P-21P.
Bingle CD, Srai SKS & Epstein O (1990) Hepatic copper distribution in Wilson's disease and hepatic copper overload. Journal of Hepatology, 11, S8-S8.
Bingle CD, Gitlin JD, Epstein O & Srai SKS (1990) Transcriptional regulation of caeruloplasmin gene expression in the developing guinea pig liver. Journal of Hepatology, 11, S7-S7.
Bingle CD, Srai SKS & Epstein O (1989) The effects of dexamethasone on fetal copper metabolism in the guinea pig. Journal of Hepatology, 9, S116-S116.
Bingle CD, Srai SK, Whiteley GS & Epstein O (1988) Neonatal and adult copper-64 metabolism in the pig and the possible relationship between the ontogeny of copper metabolism and Wilson's disease.. Biol Neonate, 54(5), 294-300.
BINGLE CD, SRAI SKS & EPSTEIN O (1987) DEVELOPMENTAL-CHANGES IN HEPATIC COPPER-BINDING PROTEINS IN THE GUINEA-PIG. J HEPATOL, 5, S95-S95.
SRAI SKS, BINGLE CD & EPSTEIN O (1986) DEVELOPMENTAL-CHANGES IN A NOVEL LOW-MOLECULAR-WEIGHT COPPER-BINDING PROTEIN (LMWP) IN GUINEA-PIG LIVER. GUT, 27(10), 1240-1240.
SRAI SKS, BINGLE CD, LEE M & EPSTEIN O (1986) SIMILARITY OF INTRAVENOUS COPPER-64 DISAPPEARANCE AND LIVER COPPER PROTEIN PROFILE IN NEONATAL PIG AND WILSONS-DISEASE - EVIDENCE FOR DEVELOPMENTAL ARREST. HEPATOLOGY, 6(5), 1119-1119.
SRAI SKS, BINGLE CD & EPSTEIN O (1986) DEVELOPMENTAL-CHANGES IN A NOVEL LOW-MOLECULAR-WEIGHT COPPER-BINDING PROTEIN (LMWP) IN GUINEA-PIG LIVER. HEPATOLOGY, 6(5), 1118-1118.
BINGLE CD, SRAI SKS, LEE M & EPSTEIN O (1986) NEONATAL AND ADULT 64 COPPER KINETICS IN THE PIG AND ITS RELATIONSHIP TO COPPER KINETICS IN WILSONS-DISEASE. GUT, 27(5), A623-A623.
Ollett L, Bingle C & Busby S () Biochemical Society Awards: what you need to know when making your nomination. The Biochemist.
Mulay A, Chowdhury MMK, James C, Bingle L & Bingle CD () The transcriptional landscape of the murine middle ear epithelium in vitro.
Bingle L, Armes H, Williams DJ, Gianfrancesco O, Chowdhury MMK, Drapkin R & Bingle CD () Expression and function of murine WFDC2 in the respiratory tract.

Chapters

Mulay A, Akram K, Bingle L & Bingle CD (2019) Isolation and Culture of Primary Mouse Middle Ear Epithelial Cells, Methods in Molecular Biology (pp. 157-168). Springer New York
Bingle CD (1996) Measurement of antioxidant gene expression, Free Radicals (pp. 287-300). Oxford University PressOxford
Srai SKS, Bingle C & Epstein O (1988) Neonatal and Adult 64Copper Metabolism in the Pig and Its Relationship to Copper Metabolism in Wilson’s Disease, Trace Elements in Man and Animals 6 (pp. 147-148). Springer US

Conference proceedings papers

Chowdhury MMK, Anujan P, Bingle L & Bingle C (2022) Defining the functions of PIERCE1 and C15ORF65 during ciliogenesis of HBEC3-KT cells. 03.02 - Airway cell biology and immunopathology
Chowdhury MMK, Bingle L & Bingle C (2022) Defining spatial secretome and ciliome across multiciliated epithelia. 03.02 - Airway cell biology and immunopathology
Alkhoshaiban A, Chowdhury MK, Anujan, P, Bingle L & Bingle C (2022) In vitro approaches to identify an antiviral role for BPIFB1 in the airway epithelium. 03.02 - Airway cell biology and immunopathology
Alharbi Z, Bingle L & Bingle C (2022) Comparative secretome analysis of differentiated epithelial cells grown at the Air liquid interface (ALI). 03.02 - Airway cell biology and immunopathology
Chowdhury MMK, Anujan P, Mulay A, Bingle L & Bingle C (2020) Comparative transcriptional analysis of differentiation in murine mucociliary epithelia. Molecular pathology and funct. genomics
Alharbi Z, Chowdhury MMK, Bingle L & Bingle C (2020) Air liquid interface (ALI)-grown immortalized human cell lines: a promising tractable model for human airway. Airway cell biology and immunopathology
Chowdhury MMK, Anujan P, Bingle L & Bingle C (2020) PIERCEing ciliogenesis: defining a role for PIERCE1 and its’ paralog C15ORF65 in multiciliogenesis. Airway cell biology and immunopathology
Bingle L, Armes H & Bingle C (2020) Expression and function of murine WFDC2 in the respiratory tract. Cystic fibrosis
ALJuhani F, Anujan P, Bingle L & Bingle C (2020) Mouse tracheal epithelial cells (mTECs) for the study of influenza A infectio>. Molecular pathology and funct. genomics
Alkhoshaiban A, Anujan P, Bingle L & Bingle C (2020) Using mouse tracheal epithelial cells (mTECs) to uncover an antiviral role for BPIFB1. Airway cell biology and immunopathology
Anujan P, Roy S, Bingle L & Bingle CD (2018) Functional analysis of PIERCE1, in motile ciliogenesis. Airway Cell Biology and Immunopathology
Caikauskaite R, Mulay A, Hood D, Brown S, Stewart J, Bingle L & Bingle C (2018) Host defence functions of BPIFA1 against Non-typeable Haemophilus influenzae. Airway Cell Biology and Immunopathology
Anujan P, Roy S & Bingle CD (2017) Functional analysis of a novel protein, Pierce1, in motile ciliogenesis in mammalian airway epithelial cells and zebrafish embryos. Mechanisms of Development, Vol. 145 (pp S25-S25)
Marshall C, Bingle L & Bingle C (2016) Interactions of BPIFA1 and BPIFB1 withS. aureus. 3.2 Airway Cell Biology and Immunopathology
Moyo N, Marchi E, Akram K, Leeming G, Tompkins M, Bingle L, Tripp R, Klenerman P, Bingle C & Stewart J (2016) LSC Abstract – A systems biology approach to aid identification of the mechanisms employed by BPIFA1/SPLUNC1 to restrict influenza A virus infection in the lung. ERS Lung Science Conference 2016
De Smet EG, Seys LJ, Verhamme FM, Vanaudenaerde BM, Joos GF, Brusselle GG, Bingle CD & Bracke KR (2016) Elevated Levels Of Bpifa1 (splunc1) And Bpifb1 (lplunc1) In Lungs Of Patients With COPD. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 193
Gao J, Ohlmeier S, Nieminen P, Toljamo T, Tiitinen S, Kanerva T, Bingle L, Araujo B, Rönty M, Höyhtyä M , Bingle C et al (2015) Elevated sputum BPIFB1 levels correlate with progression of chronic obstructive pulmonary disease. 5.2 Monitoring Airway Disease
Moyo N, Leeming G, Akram K, Tompkins M, Chapman G, Walsh T, Bingle L, Bingle C, Tripp R & Stewart J (2015) LSC Abstract – The expression and function of BPIFA1 in the pulmonary innate immune response to influenza A virus infection. 10.1 Respiratory Infections
Akram K, Moyo N, Tompkins M, Tripp R, Bingle L, Stewart J & Bingle C (2015) An innate defence role for BPIFA1/SPLUNC1 against influenza-A virus infection. 3.2 Airway Cell Biology and Immunopathology
Akram K, Anujan P, Mccloskey B, Bingle L & Bingle C (2014) Validation of an in vitro tracheal model for the study of innate host defence mechanism in respiratory tract infections. EUROPEAN RESPIRATORY JOURNAL, Vol. 44
Bingle CD, Araujo B, Wallace WA, Marriott HM, Hirani N & Bingle L (2013) BPIFB1/LPLUNC1 IS A NOVEL MARKER FOR THE BRONCHIOLISED EPITHELIUM IN IPF. THORAX, Vol. 68 (pp A139-A139)
Wilson K, Bingle L, Bingle C & Everard M (2012) Differential responses of monolayer and differentiated airway epithelial cell cultures to NTHi infection. EUROPEAN RESPIRATORY JOURNAL, Vol. 40
Bingle C, Araujo B, Marriott H, Wallace W, Hirani N & Bingle L (2012) Do characteristic airway epithelial change precede the development of lung fibrosis? Ectopic epithelial marker protein expression in bleomycin induced fibrosis replicates that seen in bronchiolized epithelium in IPF. EUROPEAN RESPIRATORY JOURNAL, Vol. 40
Araujo B, Bingle L, Marriott H, Howie S, Wallace W, Hirani N & Bingle CD (2012) LPLUNC1 (BPIFB1) As A Novel Marker For The Abnormal Epithelium In Pulmonary Fibrosis. B28. EMERGING BIOMARKERS OF COMPLEX LUNG DISEASES
Bingle CD, Wilson K, Mall M, Rassl D & Bingle L (2011) Elevated Expression Of PLUNCs In Cystic Fibrosis Lung Disease. D25. CYSTIC FIBROSIS
Bingle L, Wallace WA, Cross SS, High AS, Devine DA & Bingle CD (2004) Localisation of the putative mediator of host defence, SPLUNC1, in human tissues. JOURNAL OF PATHOLOGY, Vol. 204 (pp 45A-45A)
Renshaw SA, Bingle CD & Whyte MKB (2003) Regulation of granulocyte apoptosis by 3 novel isoforms of the BCL-2 protein, Bid. THORAX, Vol. 58 (pp 31-31)
LeClair EE, Nomellini V, Bahena M & Bingle CD (2002) Innate immunity in the oral cavity? A mouse tongue tale.. INTEGRATIVE AND COMPARATIVE BIOLOGY, Vol. 42(6) (pp 1264-1264)
Bingle L & Bingle CD (1999) Multiple components of the hedgehog signalling pathway are expressed in human pulmonary epithelial. AM J RESP CRIT CARE, Vol. 159(3) (pp A664-A664)
Gowan S, Toonen R & Bingle CD (1997) Human thyroid transcription factor-1 - Functional characterization of protein/DNA interactions on the minimal promoter region. CHEST, Vol. 111(6) (pp S88-S88)
BINGLE CD, EPSTEIN O & SRAI SKS (1991) COPPER-ZINC SUPEROXIDE-DISMUTASE IN DEVELOPING GUINEA-PIG LIVER IS NOT REGULATED BY HEPATIC COPPER LEVELS. TRACE ELEMENTS IN MAN AND ANIMALS 7 (pp 249-250)
BINGLE CD, EPSTEIN O, SRAI SKS & GITLIN JD (1991) TRANSCRIPTIONAL REGULATION OF CERULOPLASMIN GENE-EXPRESSION IN THE DEVELOPING GUINEA-PIG LIVER. TRACE ELEMENTS IN MAN AND ANIMALS 7 (pp 12-14)

Preprints

Damaa MK, Serizay J, Balagué R, Boudjema A-R, Faucourt M, Delgehyr N, Goh KJ, Lu H, Tan EK, James CT , Faucon C et al (2024) Cyclin O controls entry into the cell-cycle variant required for multiciliated cell differentiation, Cold Spring Harbor Laboratory.
Costa-Martins AG, Mane K, Lindsey BB, Ogava RLT, Castro Í, Jagne YJ, Sallah H, Armitage E, Ahadzie B, Ellis-Watson R , Tregoning JS et al () Pre-Existing Upregulation of Interferon Pathways in the Nasopharynx Impacts Viral Shedding Following Live Attenuated Influenza Vaccine Challenge in Children.
Lu H, Anujan P, Zhou F, Zhang Y, Ling Chong Y, Bingle CD & Roy S () Mcidas mutant mice reveal a two-step process for the specification and differentiation of multiciliated cells in mammals, Cold Spring Harbor Laboratory.

Grants

2018 – 2019: Biotechnology and Biological Sciences Research Council project grant. BPIFA1: from anti-viral peptide to immunomodulator.
2017 – 2021: Commonwealth Scholarship PhD Studentship. Dissecting the genetics and proteomics of the airway epithelia to identify novel mediators of multiciliogenesis pathways.
2018 – 2021: Government of Saudi Arabia PhD Studentship. The role of host cells and Staphylococcus aureus virulence factors in the initiation of respiratory infection.
2018 – 2021: Government of Saudi Arabia PhD Studentship. A role for BPIFB1 in the immunity of the respiratory tract.
2017 – 2020: Government of Saudi Arabia PhD Studentship. Uncovering the role of BPIFA1 in Influenza infection of the lung.

Teaching activities: My teaching interests lie in epithelial host defence and aspects of genetics and comparative genomics, which I teach on the MSc in Molecular Medicine. I also teach on the Undergraduate Medical, Dental and Orthoptics Courses.

Professional activities and memberships

I am Editor-in-Chief of Biochemical Society Transactions.
I am Chair of the Biochemical Society Awards Committee.
I am a member of the Portland Press Publications Committee.