Dr Charlotte Elder
BSc, MBBS, PhD, DRCOG, MRCPCH
Clinical Medicine, School of Medicine and Population Health
Senior Clinical Lecturer in Paediatric Endocrinology and UKRI Biomedical Sciences Innovation Scholar
+44 114 305 3282
Full contact details
Clinical Medicine, School of Medicine and Population Health
Room 10, The Damer Street Building
Sheffield Children's Hospital
Western Bank
Sheffield
S10 2TH
- Profile
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For enquiries, please contact – ClinMed-Operational@sheffield.ac.uk
Charlotte Elder received her undergraduate medical degree from Imperial College, (University of London) UK in 1999 and, after initially training as a general practitioner, retrained in paediatrics and further specialised in paediatric endocrinology and diabetes. She moved from London to Sheffield in 2005 in pursuit of excellent paediatric endocrinology training combined with affordable housing and fabulous local countryside.
Dr Elder started working for the University of Sheffield in 2009 when she undertook a clinical research fellowship to study for her PhD. After two years she moved to a clinical lectureship, combining her PhD work with running the Child Health undergraduate course for The Medical School. Her PhD was awarded in 2015 and she returned to clinical medicine to train in tertiary level paediatric endocrinology and diabetes but missed academia, so 8 months later returned to The University of Sheffield as an NIHR Academic Clinical Lecturer. In May 2018 Dr Elder took up the post of Consultant in Paediatric Endocrinology and Diabetes at Sheffield Children’s Hospital and three months later was appointed as Senior Clinical Lecturer at the University. In June 2021 Dr Elder started a three year secondment as a UKRI Biomedical Science Innovation Scholar. Clinically her specialist interests are adrenal insufficiency, adrenal function testing and paediatric and adolescent gynaecology.
Dr Elder is passionate about fostering research interests in junior colleagues and making research accessible for all health care professionals. She has supervised over 75 medical students and junior doctors, helping them present, publish and win prizes. Her enthusiasm extends to teaching and she was awarded a Clinical Teaching Award by the University in 2015 and appointed Director of Undergraduate Medical Education at Sheffield Children’s NHS Foundation Trust in 2021.
- Research interests
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Charlotte Elder's main research area is adrenal insufficiency, with the development of a non-invasive Short Synacthen Test (diagnostic test), using a novel formulation of Synacthen (Nasacthin) for nasal administration and the measurement of the glucocorticoid response in saliva samples. She has led a team over five pharmacokinetic studies in adults and children and is currently working up the next phase of clinical trials. There is a patent application filed for the novel formulation and both commercial and research arms to the current workstream. She is the lead for a clinical trial looking to determine whether awakening salivary cortisone is an effective screening test for adrenal insufficiency in children (SCAIT-junior study) and is working on novel approaches to salivary collection in very young children and babies (NITS study). She is involved with other related projects, particularly involving iatrogenic adrenal insufficiency caused by prescription corticosteroids.
Charlotte's other research interests include a cross-discipline bioengineering project developing pubertal simulation tools for training purposes.
Current projects:
- Nasal Tetracosactide and Chitosan for Adrenal Stimulation - Chief Investigator
- Randomised, double-blinded, placebo-controlled cross-over trial in healthy women, men and children
- Randomised cross-over trial in a patient population with adrenal insufficiency
- Normative data study in healthy children to derive reference centiles for The Nasacthin Test
- SCAIT-junior (Salivary Cortisone Adrenal Insufficiency Test) assessing awakening salivary cortisone for AI screening - Chief investigator
- NITS (Neonatal, Infant and Toddler salivary collection study) - Chief investigator
- ACTH and cortisol modelling to improve AI screening - Co-lead
- Tertiary Adrenal Insufficiency programme of work - Co-lead
- Nasal Tetracosactide and Chitosan for Adrenal Stimulation - Chief Investigator
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- Fifteen-minute consultation : the child with obesity. Archives of Disease in Childhood: Education & Practice.
- Training using a simulation-based workshop reduces inaccuracies in estimations of testicular volume. Journal of Pediatric Endocrinology and Metabolism, 34(1), 65-70.
- Pharmacodynamic studies of nasal tetracosactide with salivary glucocorticoids for a noninvasive Short Synacthen Test. Journal of Clinical Endocrinology and Metabolism, 105(8), 2692-2703. View this article in WRRO
- A simulation study assessing the accuracy and reliability of orchidometer estimation of testicular volume. Clinical Endocrinology. View this article in WRRO
- Use of salivary cortisol and cortisone in the high and low dose synacthen test. Clinical Endocrinology, 88(6), 772-778. View this article in WRRO
- International survey on high- and low-dose synacthen test and assessment of accuracy in preparing low-dose synacthen. Clinical Endocrinology, 88(5), 744-751. View this article in WRRO
- Integrating teaching into everyday clinical practice. Archives of Disease in Childhood Education and Practice Edition, 102(2), 94-99. View this article in WRRO
- Hydrocortisone for adrenal insufficiency. Archives of Disease in Childhood.education and Practice Edition, 100(5), 272-276. View this article in WRRO
- Rickets.. Lancet, 383(9929), 1665-1676. View this article in WRRO
- Letter in response to Chitale et al.: determining the utility of the 60-minute cortisol measurement in the short synacthen test.. Clin Endocrinol (Oxf), 80(6), 925. View this article in WRRO
- The short Synacthen test: a questionnaire survey of current usage.. Arch Dis Child, 97(10), 870-873.
All publications
Journal articles
- Real world evidence supports waking salivary cortisone as a screening test for adrenal insufficiency. Clinical Endocrinology. View this article in WRRO
- OR30-01: Waking salivary 11-hydroxyandrostenedione and cortisone as a novel non-invasive test for adrenal insufficiency. Journal of the Endocrine Society, 7(Supplement_1), bvad114.351. View this article in WRRO
- Fifteen-minute consultation: approach to the adolescent presenting with hirsutism. Archives of disease in childhood - Education & practice edition.
- Main salivary steroid collection in children under conditions replicating home sampling. Journal of Clinical Endocrinology and Metabolism.
- Fifteen-minute consultation : the child with obesity. Archives of Disease in Childhood: Education & Practice.
- Training using a simulation-based workshop reduces inaccuracies in estimations of testicular volume. Journal of Pediatric Endocrinology and Metabolism, 34(1), 65-70.
- Pharmacodynamic studies of nasal tetracosactide with salivary glucocorticoids for a noninvasive Short Synacthen Test. Journal of Clinical Endocrinology and Metabolism, 105(8), 2692-2703. View this article in WRRO
- Non classic presentations of a genetic mutation typically associated with transient neonatal diabetes. Endocrinology, Diabetes & Metabolism Case Reports, 2020(1). View this article in WRRO
- Obesity : unrecognised or avoided? We are missing opportunities to ‘make every contact count’. Archives of Disease in Childhood. View this article in WRRO
- How do paediatricians use and monitor antithyroid drugs in the UK? A clinician survey. Clinical Endocrinology. View this article in WRRO
- Update on adrenal steroid hormone biosynthesis and clinical implications. Archives of Disease in Childhood. View this article in WRRO
- A simulation study assessing the accuracy and reliability of orchidometer estimation of testicular volume. Clinical Endocrinology. View this article in WRRO
- Use of salivary cortisol and cortisone in the high and low dose synacthen test. Clinical Endocrinology, 88(6), 772-778. View this article in WRRO
- International survey on high- and low-dose synacthen test and assessment of accuracy in preparing low-dose synacthen. Clinical Endocrinology, 88(5), 744-751. View this article in WRRO
- The use of a radiolucent template to improve bone age X-ray quality (BASIC study). Journal of Pediatric Endocrinology and Metabolism, 30(12). View this article in WRRO
- Integrating teaching into everyday clinical practice. Archives of Disease in Childhood Education and Practice Edition, 102(2), 94-99. View this article in WRRO
- Diabetes insipidus and the use of desmopressin in hospitalised children.. ADC Education & Practice. View this article in WRRO
- G354(P) ‘bridges and barriers’ : middle grade perspectives about contacting on-call general paediatric consultants. Archives of Disease in Childhood, 101(Suppl 1). View this article in WRRO
- Hydrocortisone for adrenal insufficiency. Archives of Disease in Childhood.education and Practice Edition, 100(5), 272-276. View this article in WRRO
- Height estimation using long bone segment length is unlikely to play a role in the routine measurement of healthy preschool children. Developmental Medicine & Child Neurology, 56(10), 921-922. View this article in WRRO
- Rickets.. Lancet, 383(9929), 1665-1676. View this article in WRRO
- Letter in response to Chitale et al.: determining the utility of the 60-minute cortisol measurement in the short synacthen test.. Clin Endocrinol (Oxf), 80(6), 925. View this article in WRRO
- Early glycaemic control is predictive of long-term control: A retrospective observational study. Practical Diabetes, 30(1), 16-18.
- Correction. Archives of Disease in Childhood, 97(11), 1008-1008.
- Response to Alleyn et al. Comparison of longitudinal point-of-care and high-performance liquid chromatography HbA1c measurements in a multi-centre trial. Diabetic Medicine, 29(9), 1213-1214.
- The short Synacthen test: a questionnaire survey of current usage.. Arch Dis Child, 97(10), 870-873.
- The short Synacthen test: A questionnaire survey of current usage. Archives of Disease in Childhood, 97(10), 870-873.
- HbA1c league tables: might assay variability encourage foul play?. Journal of Clinical Pathology, 63(7), 660-660.
- Mauriac Syndrome - A Modern Reality. J PEDIATR ENDOCR MET, 23(3), 311-313.
- Time to end the routine testing of growth hormone and cortisol on hypoglycaemia screens?. ARCH DIS CHILD, 94(12), 1000-1001.
- Audit cycle of newborn observations on the postnatal wards.. Archives of Disease in Childhood - Fetal and Neonatal Edition, 93(6), f475.
- Audit cycle of newborn observations on the postnatal wards. ARCH DIS CHILD-FETAL, 93(6), 1475-1475.
- A Randomised Study of the Effect of Two Doses of Biosynthetic Human Growth Hormone on Final Height of Children with Familial Short Stature. Hormone Research, 70(2), 89-92.
- Growth patterns in the growth-retarded premature infant.. Best Pract Res Clin Endocrinol Metab, 22(3), 447-462.
- Severe chest recession causing translucency on an x ray.. Arch Dis Child Fetal Neonatal Ed, 93(1), F23.
- Limitations of empirical therapy for bacterial meningitis in a healthy child with Listeria monocytogenes meningitis. Journal of Pediatric Neurology, 4(1), 65-67.
- A retrospective study on weaning glucocorticoids and recovery of the hypothalamic-pituitary-adrenal axis. The Journal of Clinical Endocrinology & Metabolism.
- Home waking salivary cortisone to screen for adrenal insufficiency in children. Endocrine Abstracts.
- Defining the basal serum cortisol cut-off for weaning patients off glucocorticoids in suspected tertiary adrenal insufficiency. Endocrine Abstracts.
- Multivariable model to predict an ACTH stimulation test to diagnose adrenal insufficiency using previous test results. Journal of the Endocrine Society.
- Retrospective study of steroid weaning in tertiary adrenal insufficiency comparing prednisolone and hydrocortisone. Endocrine Abstracts.
- Emergency and perioperative management of adrenal insufficiency in children and young people: British Society for Paediatric Endocrinology and Diabetes consensus guidance. Archives of Disease in Childhood.
- Home Waking Salivary Cortisone to Screen for Adrenal Insufficiency. NEJM Evidence.
- Recommendations for hydrocortisone doses for emergency management and peri-operative care for childhood adrenal insufficiency. BSPED consensus guidelines. Endocrine Abstracts.
Conference proceedings papers
- Borderline peak plasma cortisol following Synacthen stimulation - single-centre analysis of three years' data. Endocrine Abstracts, Vol. 90(S1) (pp 146-146), 27 September 2018 - 29 September 2018. View this article in WRRO
- The relationship of baseline, incremental and peak cortisol following a Short Synacthen Test - single-centre analysis of three years' data. Hormone Research in Paediatrics, Vol. 90(Suppl 1) (pp 128-129), 27 September 2018 - 29 September 2018. View this article in WRRO
- G175(P) Current dilution methods cause large variations and inaccuracies when making up 1MCG synacthen dose. British Society for Paediatric Endocrinology and Diabetes and British Society of Paediatric Gastroenterology, Hepatology and Nutrition
- The relationship of baseline, incremental and peak cortisol following a Short Synacthen Test - single-centre analysis of three years' data. Endocrine Abstracts
- Fifteen-minute consultation : the child with obesity. Archives of Disease in Childhood: Education & Practice.