Dr Andrew Narracott
MPhys, PhD
Clinical Medicine, School of Medicine and Population Health
Senior Lecturer in Cardiovascular Mechanics
a.j.narracott@sheffield.ac.uk
+44 114 215 9540
+44 114 215 9540
The Medical School
Full contact details
Dr Andrew Narracott
Clinical Medicine, School of Medicine and Population Health
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Clinical Medicine, School of Medicine and Population Health
The Medical School
Beech Hill Road
Sheffield
S10 2RX
- Profile
-
For enquiries please contact - ClinMed-Operational@sheffield.ac.uk
I joined the University of Sheffield in 1993 and completed an undergraduate Physics Degree in 1997 and a PhD in Medical Physics in 2002.
The focus of my PhD study was the interaction between balloon catheters and coronary stents during stent deployment and involved the use of both experimental and numerical techniques to address the problem.
Between 2001 and 2007 I worked on a number of projects addressing a range of biomechanical applications. These include; Bloodsim (EU FP7), a commercial project funded by the Trustees for the Bowling-Pfizer Heart Valve Settlement Funds, a study of deep vein thrombosis treatment funded by the EPSRC and a six month period spent in Tokyo, Japan funded by the RIKEN institute to develop models of blood clotting in cerebral aneurysms.
I currently teach a 3rd year undergraduate course in the application of numerical methods to clinical engineering problems. For current research projects please see the list below and associated web-links.
- Research interests
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My research interest is the application of numerical techniques to the study of cardiovascular systems, with development of associated experimental validation methods.
Application areas include coronary artery stenting, native and prosthetic valve function and venous haemodynamics. Such applications cover a range of technical areas including structural mechanics, Computational Fluid Dynamics, Fluid-Structure Interaction and multi-scale approaches for biological systems.
Recent Projects
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- Virtual physiological human: training challenges (vol 368, pg 2841, 2010). PHILOS T R SOC A, 369(1935), 494-494.
- Analysis of a mechanical heart valve prosthesis and a native venous valve: Two distinct applications of FSI to biomedical applications. INT J NUMER METH BIO, 26(3-4), 421-434.
- Adaptation and development of software simulation methodologies for cardiovascular engineering: present and future challenges from an end-user perspective.. Philos Trans A Math Phys Eng Sci, 367(1898), 2655-2666.
- A validated model of calf compression and deep vessel collapse during external cuff inflation.. IEEE Trans Biomed Eng, 56(2), 273-280.
- Fundamental mechanics of aortic heart valve closure.. J Biomech, 39(5), 958-967.
- Development and validation of models for the investigation of blood clotting in idealized stenoses and cerebral aneurysms.. J Artif Organs, 8(1), 56-62.
- Measurement of the symmetry of in vitro stent expansion: a stereo-photogrammetric approach.. J Med Eng Technol, 27(2), 59-70.
All publications
Journal articles
- Evaluation of models of sequestration flow in coronary arteries—physiology versus anatomy?. Computers in Biology and Medicine, 173. View this article in WRRO
- Sex differences in coronary microvascular resistance measured by a computational fluid dynamics model. Frontiers in Cardiovascular Medicine, 10. View this article in WRRO
- Modelling the hemodynamics of coronary ischemia. Fluids, 8(5).
- A multiscale computational framework to evaluate flow alterations during mechanical thrombectomy for treatment of ischaemic stroke. Frontiers in Cardiovascular Medicine, 10.
- Quality Assuring a Ring Vortex Flow Phantom in Real-Time. Open Journal of Medical Imaging, 13(01), 11-29.
- Integrating particle tracking with computational fluid dynamics to assess haemodynamic perturbation by coronary artery stents. PLoS ONE, 17(7). View this article in WRRO
- The use of digital coronary phantoms for the validation of arterial geometry reconstruction and computation of virtual FFR. Fluids, 7(6). View this article in WRRO
- Determining clinically-viable biomarkers for ischaemic stroke through a mechanistic and machine learning approach. Annals of Biomedical Engineering. View this article in WRRO
- The importance of three dimensional coronary artery reconstruction accuracy when computing virtual fractional flow reserve from invasive angiography.. Sci Rep, 11(1), 19694.
- An Encounter with Lattice Boltzmann for Biomedical Applications: Interactive Simulation to Support Clinical and Design Decisions. Journal of Engineering and Science in Medical Diagnostics and Therapy.
- Delivering computationally-intensive Digital Patient applications to the clinic: an exemplar solution to predict femoral bone strength from CT data. Computer Methods and Programs in Biomedicine, 106200-106200.
- A novel method for measuring absolute coronary blood flow & microvascular resistance in patients with ischaemic heart disease. Cardiovascular Research. View this article in WRRO
- Subject-specific simulation for non-invasive assessment of aortic coarctation: Towards a translational approach. Medical Engineering and Physics. View this article in WRRO
- A complex flow phantom for medical imaging : ring vortex phantom design and technical specification. Journal of Medical Engineering & Technology, 43(3), 190-201. View this article in WRRO
- 60 An atlas of computed FFR in common patterns of coronary artery disease. Heart, 105(Suppl 6), a51-a51. View this article in WRRO
- Full-field analysis of epicardial strain in an in vitro porcine heart platform. Journal of the Mechanical Behavior of Biomedical Materials, 91, 294-300. View this article in WRRO
- An automatic method for aortic segmentation based on level-set methods using multiple seed points. Lecture Notes in Computational Vision and Biomechanics, 27, 875-882.
- Modeling regulation of vascular tone following muscle contraction: Model development, validation and global sensitivity analysis. Journal of Computational Science, 24, 143-159. View this article in WRRO
- VPH-CaSE - VPH-Cardiovascular Simulation and Experimentation for Personalised Medical Devices - H2020. Impact, 2017(10), 20-22.
- Computer model for the cardiovascular system: development of an e-learning tool for teaching of medical students. BMC Medical Education, 17(1), 220-220. View this article in WRRO
- The Accuracy of 3D Optical Reconstruction and Additive Manufacturing Processes in Reproducing Detailed Subject-Specific Anatomy. Journal of Imaging, 3(4). View this article in WRRO
- The Ring Vortex: Concepts for a Novel Complex Flow Phantom for Medical Imaging. Open Journal of Medical Imaging, 07(01), 28-41. View this article in WRRO
- Global sensitivity analysis of a model for venous valve dynamics. Journal of Biomechanics, 49(13), 2845-2853. View this article in WRRO
- Computational fluid dynamics modelling in cardiovascular medicine. Heart, 102(1), 18-28. View this article in WRRO
- A 1D pulse wave propagation model of the hemodynamics of calf muscle pump function. International Journal for Numerical Methods in Biomedical Engineering, 31(7). View this article in WRRO
- Measurement of in vitro and in vivo Stent Geometry and Deformation by Means of 3D Imaging and Stereo-Photogrammetry. The International Journal of Artificial Organs, 37(12), 918-927.
- From Histology and Imaging Data to Models for In-Stent Restenosis. The International Journal of Artificial Organs, 37(10), 786-800.
- Contribution of Mechanical and Fluid Stresses to the Magnitude of In-stent Restenosis at the Level of Individual Stent Struts. Cardiovascular Engineering and Technology, 5(2), 164-175.
- Uncertainty assessment of imaging techniques for the 3D reconstruction of stent geometry.. Med Eng Phys, 36(8), 1062-1068.
- Endothelial repair process and its relevance to longitudinal neointimal tissue patterns: comparing histology with in silico modelling.. J R Soc Interface, 11(94), 20140022.
- A framework for different levels of integration of computational models into web-based virtual patients.. J Med Internet Res, 16(1), e23.
- Validation of a patient-specific hemodynamic computational model for surgical planning of vascular access in hemodialysis patients. Kidney International, 84(6), 1237-1245.
- The effects of stenting on shear stress: relevance to endothelial injury and repair.. Cardiovasc Res, 99(2), 269-275.
- Stent Geometry Reconstruction Using Imaging Techniques1. Journal of Medical Devices, 7(4).
- Stent geometry reconstruction using imaging techniques. ASME 2013 Conference on Frontiers in Medical Devices: Applications of Computer Modeling and Simulation, FMD 2013.
- MICRO-CT RENDERED IMAGES OF STENTED CORONARIES AND THE PHENOMENA OF IN-STENT RESTENOSIS. Journal of Biomechanics, 45, S145-S145.
- CFD ANALYSIS OF THE REGURGITANT FLOW IN A BILEAFLET MECHANICAL HEART VALVE. Journal of Biomechanics, 45, S130-S130.
- VIRTUAL METHODS FOR VERIFICATION OF STEREOSCOPIC STRAIN MEASUREMENT. Journal of Biomechanics, 45, S15-S15.
- INFLUENCE OF STENT STRUT DISTRIBUTION ON LOCAL VESSEL STRESS. Journal of Biomechanics, 45, S25-S25.
- EXPERIMENTAL CHARACTERISATION OF AN OPTICAL SYSTEM AT CORONARY ARTERY LENGTH SCALES. Journal of Biomechanics, 45, S23-S23.
- Computational fluid dynamic analysis of the regurgitant flow in a bileaflet mechanical heart valve. ECCOMAS 2012 - European Congress on Computational Methods in Applied Sciences and Engineering, e-Book Full Papers, 7982-7989.
- Virtual physiological human: training challenges (vol 368, pg 2841, 2010). PHILOS T R SOC A, 369(1935), 494-494.
- Innovative design of a venous valve intended for PIV measurements. ASME 2011 Summer Bioengineering Conference, SBC 2011(PARTS A AND B), 1111-1112.
- Hemodynamics and in-stent restenosis: micro-CT images, histology, and computer simulations.. Ann Biomed Eng, 39(10), 2615-2626.
- Virtual physiological human: training challenges.. Philos Trans A Math Phys Eng Sci, 368(1921), 2841-2851.
- Analysis of a mechanical heart valve prosthesis and a native venous valve: Two distinct applications of FSI to biomedical applications. INT J NUMER METH BIO, 26(3-4), 421-434.
- Adaptation and development of software simulation methodologies for cardiovascular engineering: present and future challenges from an end-user perspective.. Philos Trans A Math Phys Eng Sci, 367(1898), 2655-2666.
- A validated model of calf compression and deep vessel collapse during external cuff inflation.. IEEE Trans Biomed Eng, 56(2), 273-280.
- MULTI-PHYSICS & MULTI-SCALE MODELLING: CLOSURE DYNAMICS OF A BILEAFLET PROSTHETIC HEART VALVE. Journal of Biomechanics, 41, S241-S241.
- A VALIDATED MODEL OF VENOUS FLOW AUGMENTATION DURING INTERMITTENT PNEUMATIC COMPRESSION. Journal of Biomechanics, 41, S270-S270.
- GRAVITY AND VENOUS VALVE BLOOD “WASH OUT”: A 3D MODEL. Journal of Biomechanics, 41, S272-S272.
- The role of venous valves in pressure shielding.. Biomed Eng Online, 7, 8-8. View this article in WRRO
- Multiphysics and multiscale simulation: Application to a coupled model of the left ventricle and a mechanical heart valve. INT J MULTISCALE COM, 6(1), 65-76.
- Influence of intermittent compression cuff design on calf deformation: computational results.. Conf Proc IEEE Eng Med Biol Soc, 2007, 6334-6338.
- Influence of intermittent compression cuff design on interface pressure and calf deformation: experimental results.. Conf Proc IEEE Eng Med Biol Soc, 2007, 2122-2125.
- Balloon folding affects the symmetry of stent deployment: experimental and computational evidence.. Conf Proc IEEE Eng Med Biol Soc, 2007, 3069-3073.
- A modelling framework to predict haemodynamics in the deep veins of the calf during external intermittent compression therapy. Journal of Biomechanics, 39, S281-S281.
- Computation of closure forces for mechanical heart valves. Journal of Biomechanics, 39, S305-S305.
- Mass transport across the arterial wall from drug eluting stents. Journal of Biomechanics, 39, S633-S633.
- Ultrasound investigation of lower limb haemodynamics during compression using a water-filled cuff. Journal of Biomechanics, 39, S301-S302.
- Fundamental mechanics of aortic heart valve closure.. J Biomech, 39(5), 958-967.
- Development and validation of models for the investigation of blood clotting in idealized stenoses and cerebral aneurysms.. J Artif Organs, 8(1), 56-62.
- A thermal analogy for modelling drug elution from cardiovascular stents.. Comput Methods Biomech Biomed Engin, 7(5), 257-264.
- Travel Award: Asian-Ocean Researchers and Overseas Young Investigators. 人工臓器, 32(2Supplement), s59-s63.
- Measurement of the symmetry of in vitro stent expansion: a stereo-photogrammetric approach.. J Med Eng Technol, 27(2), 59-70.
- Nominal size in six bileaflet mechanical aortic valves: A comparison of orifice size and biologic equivalence. Journal of Thoracic and Cardiovascular Surgery, 125(6), 1388-1393.
- Fluid-solid interaction: benchmarking of an external coupling of ANSYS with CFX for cardiovascular applications.. J Med Eng Technol, 27(1), 23-31.
- Neonatal lungs: maturational changes in lung resistivity spectra.. Med Biol Eng Comput, 40(5), 506-511.
- Neonatal lungs--can absolute lung resistivity be determined non-invasively?. Med Biol Eng Comput, 40(4), 388-394.
- Development of an ex vivo model to investigate the effects of altered haemodynamics on human bypass grafts.. J Med Eng Technol, 24(5), 183-191.
- Computational modelling of cardiovascular pathophysiology to risk stratify commercial spaceflight. Nature Reviews Cardiology.
- 3D ePTFE heart valve leaflet analysis using multi high speed camera digital image correlation, 105-106.
- Rapid virtual fractional flow reserve using 3D computational fluid dynamics. European Heart Journal - Digital Health.
- The Complementary Value of Absolute Coronary Flow in the Assessment of Patients with Ischaemic Heart Disease. Nature Cardiovascular Research.
- Operator-Dependent Variability of Angiography-Derived Fractional Flow Reserve and the Implications for Treatment. European Heart Journal - Digital Health.
- P11.11 VENOUS VALVES DYNAMICS AND THE HEMODYNAMICS OF THE MUSCLE PUMP EFFECT: A MODELING APPROACH. Artery Research, 8(4), 163-163.
- A particle-based model for endothelial cell migration under flow conditions. Biomechanics and Modeling in Mechanobiology. View this article in WRRO
- Location-specific comparison between a 3D in-stent restenosis model and micro-CT and histology data from porcine in vivo experiments. Cardiovascular Engineering and Technology. View this article in WRRO
- Measurement of in vitro cardiac deformation by means of 3D digital image correlation and ultrasound 2D speckle-tracking echocardiography. Medical Engineering & Physics. View this article in WRRO
Chapters
- Local Sensitivity Analysis of a Closed-Loop in Silico Model of the Human Baroregulation, Computational Science – ICCS 2024 (pp. 173-187). Springer Nature Switzerland
- Noninvasive Estimation of Mean Pulmonary Artery Pressure Using MRI, Computer Models, and Machine Learning, Computational Science – ICCS 2022 (pp. 14-27). Springer International Publishing
- The Venous System, Cardiovascular Biomechanics (pp. 127-142). Springer International Publishing
Conference proceedings papers
- 220 Sensitivity of computed coronary physiology to murray’s law of vascular scaling. Stable IHD/Prevention/Hypertension/Lipids
- Serverless Approach to Sensitivity Analysis of Computational Models. 2023 IEEE/ACM 23rd International Symposium on Cluster, Cloud and Internet Computing (CCGrid), 1 May 2023 - 4 May 2023.
- In Vitro Modelling for Bulging Sinus Effects of an Expanded Polytetrafluoroethylene Valved Conduit Based on High-Speed 3D Leaflet Evaluation. 2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), 11 July 2022 - 15 July 2022.
- Sensitivity analysis of a model of lower limb haemodynamics. Computational Science – ICCS 2022 : 22nd International Conference, London, UK, June 21–23, 2022, Proceedings, Part III (pp 65-77). London, UK, 21 June 2022 - 23 June 2022.
- pFIRE: parallel Framework for Image REgistration. Compbiomed Conference 2021
- Modeling Approach for An Aortic Dissection with Endovascular Stenting*. 2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), 20 July 2020 - 24 July 2020.
- Analysis of Speckle Pattern Quality and Uncertainty for Cardiac Strain Measurements Using 3D Digital Image Correlation (pp 883-892) View this article in WRRO
- The Ring Vortex: A candidate for a liquid-based complex flow phantom for medical imaging. VipIMAGE 2017, Vol. 27 (pp 893-902) View this article in WRRO
- Multi-physics and Multi-scale Computational Evaluation of the Thrombogenic and Cavitational Potential of a Bileaflet Mechanical Heart Valve (pp 298-305)
- CFD Analysis Study on the Impact of the Coronary Anatomy on the Efficiency of the Coronary Thrombectomy: The Effect of Bend Angles (pp 306-309)
- Modelling the Development of In-Stent Restenosis: Preliminary Results of a Structural Model. INTERNATIONAL CONFERENCE ON ADVANCEMENTS OF MEDICINE AND HEALTH CARE THROUGH TECHNOLOGY, Vol. 36 (pp 276-279)
- Strain Measurement in an Elastic Material under Large Deformation Using Optical Reconstruction Methods. INTERNATIONAL CONFERENCE ON ADVANCEMENTS OF MEDICINE AND HEALTH CARE THROUGH TECHNOLOGY, Vol. 36 (pp 120-+)
- EXPERIMENTAL STUDIES AND NUMERICAL SIMULATIONS OF SOME MECHANICAL HEART VALVES' BIOMECHANICS. MANAGEMENT OF TECHNOLOGICAL CHANGES, VOL 1 (pp 445-448)
- Closure Mechanics of Mechanical Heart Valve Prostheses - Experimental and Computational Analysis. INTERNATIONAL CONFERENCE ON ADVANCEMENTS OF MEDICINE AND HEALTH CARE THROUGH TECHNOLOGY, Vol. 26 (pp 363-368)
- Investigations of the thrombogenic and cavitational potentials of a bileaflet mechanical heart valve, using ANSYS-CFX. 2008 IEEE INTERNATIONAL CONFERENCE ON AUTOMATION, QUALITY AND TESTING, ROBOTICS (AQTR 2008), THETA 16TH EDITION, VOL III, PROCEEDINGS (pp 106-111)
- The Cavitational Potential of a Single-leaflet Virtual MHV: A Multi-Physics and Multiscale Modelling Approach. 11TH MEDITERRANEAN CONFERENCE ON MEDICAL AND BIOLOGICAL ENGINEERING AND COMPUTING 2007, VOLS 1 AND 2, Vol. 16(1-2) (pp 895-898)
- Multi-physics and multi-scale modelling in cardiovascular physiology: Advanced user methods for simulation of biological systems with ANSYS/CFX. Computational Science - ICCS 2007, Pt 1, Proceedings, Vol. 4487 (pp 794-801)
- Continuity equation area in bileaflet prosthetic aortic valves: Valve size cannot be substituted for LV outflow tract diameter. HEART, Vol. 89 (pp 41-41)
- Restitution of a tubular lumen after stent implantation in porcine coronary arteries. AMERICAN JOURNAL OF CARDIOLOGY, Vol. 92(6A) (pp 208L-208L)
Preprints
- Noninvasive Estimation of Mean Pulmonary Artery Pressure Using MRI, Computer Models, and Machine Learning, arXiv.
- Serverless Approach to Sensitivity Analysis of Computational Models, arXiv.
- The Accuracy of Virtual Fractional Flow Reserve From Invasive Angiography: Importance of the Method of Reconstructing Three-dimensional Coronary Artery Anatomy, Research Square Platform LLC.
- Virtual physiological human: training challenges (vol 368, pg 2841, 2010). PHILOS T R SOC A, 369(1935), 494-494.
- Research group
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- Paolo Ferraiuoli
- Teaching interests
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My teaching interests cover the application of numerical techniques to the study of biomedical problems, with emphasis on clinical applications.
This includes a 3rd year course using Matlab and ANSYS to introduce finite difference and finite element techniques for the study of structural, fluid and thermal problems and the extension of this into 3rd and 4th year undergraduate research projects.