Professor Thushan de Silva

MBE FRCP FRSB FMedSci

School of Medicine and Population Health

Professor of Infectious Diseases

Honorary Consultant Physician in Infectious Diseases

t.desilva@sheffield.ac.uk
+44 114 215 9532

The Medical School

Full contact details

Professor Thushan de Silva
School of Medicine and Population Health
The Medical School
Beech Hill Road
Sheffield
S10 2RX

Profile

I am an Infectious Diseases Clinician Scientist with a programme of research centred around clinical discovery science in the UK and Africa. Our group applies a broad range of methods including human immunology, epidemiology, molecular diagnostics and genomics, to establish how pathogens interact with human hosts at population and individual levels. We work primarily on respiratory viruses such as influenza and SARS-CoV-2, and Streptococcus pyogenes (Group A Streptococcus), investigating the natural history of infection and immunity to inform the design of diagnostic tools, vaccines, and other preventative measures. A specific area of interest is also how immunocompromising conditions such as HIV and haematopoietic stem cell transplantation impact the clinical risk and vaccine-induced immunity to respiratory viruses.

I am part of the Clinical Infection Research Group (CIRG) in the Medical School at the University of Sheffield and am an Honorary Consultant Physician in Infectious Diseases in the South Yorkshire Regional Department of Infection and Tropical Medicine in Sheffield. I am co-director of the Florey Institute of Infection and lead the host-pathogen interactions theme. I am also a Principal Investigator in the Vaccines and Immunity Theme at the Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine.

I completed my undergraduate medical training at the University of Bristol in 2000. Following postgraduate clinical training in General Internal Medicine, Infectious Diseases and HIV in Oxford and London, I moved to Sheffield for higher specialist training in Infectious Diseases & Microbiology in 2004. After relocating to The MRC Unit The Gambia in 2007, I was awarded a British Infection Society Research Fellowship (2007-8), followed by a MRC Clinical Research Training Fellowship and PhD (2008 – 11) under the supervision of Professor Sarah Rowland-Jones and Professor Robin Weiss, to study the pathogenesis of HIV-2 infection and the molecular epidemiology of HIV-1 and HIV-2 in West Africa.

I joined the University of Sheffield in 2013 as an NIHR Academic Clinical Lecturer in Infectious Diseases & Microbiology. I was awarded a Wellcome Trust Intermediate Clinical Fellowship (2016 -2021), based between Imperial College London and the MRC Unit The Gambia, to study the immunogenicity of intranasal Live Attenuated Influenza Vaccine in children and bidirectional interactions with nasopharyngeal microbiota. I returned to the University of Sheffield as a Senior Clinical Lecturer in 2020 and led a programme of SARS-CoV-2 research through the COVID-19 pandemic, including roles as lead PI in Sheffield for the COG-UK consortium and the PITCH study.

I was awarded an MBE in 2021 for services to COVID-19 research.

Research interests

Our work involves molecular epidemiology and immuno-epidemiology to gain insights into population- and individual-level patterns of infections and immunity the following areas:

Host immunity and prevention of respiratory infections. We investigate the mechanisms, durability and determinants of immune protection against respiratory pathogens, including SARS-CoV-2, influenza and RSV, with a particular focus on mucosal and systemic immunity, inflammatory memory, and correlates of protection. This work spans natural infection, vaccination and immunocompromised populations, including people living with HIV and recipients of haematopoietic stem cell transplantation. We also develop and evaluate novel host-directed approaches to enhance respiratory epithelial defences and reduce susceptibility to infection.
Epidemiology, transmission and surveillance of infectious diseases. We apply molecular epidemiology, genomics and large-scale population health data to understand patterns of infectious disease transmission, susceptibility and outcomes. Current work includes household transmission studies of respiratory pathogens, the evaluation and implementation of novel diagnostic and sequencing approaches for surveillance, and the use of electronic health records and linked datasets to identify risk factors for severe disease and improve strategies for prevention in vulnerable populations.
Streptococcus pyogenes epidemiology and immunity. We seek to define the determinants of transmission, natural immunity and immune protection against S. pyogenes, particularly in settings with a high burden of disease. Through observational studies, human challenge models and international collaborative networks, our work aims to identify correlates of protection and generate evidence to support vaccine development.

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Sanyang B, Dabrowska MB, Amenyogbe N, Camara B, Beloum N, Jammeh M, Bojang D, Goodall J, Mohammed N, Sesay AK , Roca A et al (2025) Effect of intrapartum azithromycin on early childhood gut mycobiota development: post hoc analysis of a double-blind randomized trial. Nature Communications, 16. View this article in WRRO
Keeley AJ, Camara FE, Armitage EP, de Crombrugghe G, Sillah J, Fofana ML, Rollinson V, Senghore E, Jammeh M, Whitcombe AL , Bittaye A et al (2025) Early-life serological profiles and the development of natural protective humoral immunity to Streptococcus pyogenes in a high-burden setting. Nature Medicine, 31(10), 3360-3371. View this article in WRRO
Hao S, Tomic I, Lindsey BB, Jagne YJ, Hoschler K, Meijer A, Carreño Quiroz JM, Meade P, Sano K, Peno C , Costa-Martins AG et al (2025) Integrative mapping of pre-existing influenza immune landscapes predicts vaccine response. Journal of Clinical Investigation, 135(18). View this article in WRRO
Armitage EP, Senghore E, Camara FE, Jarju S, Jagne S, Ceesay E, Darboe FF, de Crombrugghe G, Keeley AJ, Hall JN , Angyal A et al (2025) Evaluating clinical decision rules and rapid diagnostic tests for the diagnosis of Streptococcus pyogenes pharyngitis in Gambian children: A diagnostic accuracy study. Journal of Infection, 91(2), 106546-106546.
Colton H, Barratt N, Temperton N, Hornsby H, Angyal A, Grouneva I, Lindsey BB, Kearns P, Barnes E, Goodyear CS , Richter A et al (2024) Greater preservation of SARS‐CoV‐2 neutralising antibody responses following the ChAdOx1‐S (AZD1222) vaccine compared with mRNA vaccines in haematopoietic cell transplant recipients. British Journal of Haematology, 205(6), 2206-2218. View this article in WRRO
Armitage EP, de Crombrugghe G, Keeley AJ, Senghore E, Camara FE, Jammeh M, Bittaye A, Ceesay H, Ceesay I, Samateh B , Manneh M et al (2024) Streptococcus pyogenes carriage and infection within households in The Gambia: a longitudinal cohort study. The Lancet Microbe, 5(7), 679-688.
Jarju S, Wenlock RD, Danso M, Jobe D, Jagne YJ, Darboe A, Kumado M, Jallow Y, Touray M, Ceesay EA , Gaye H et al (2024) High SARS-CoV-2 incidence and asymptomatic fraction during Delta and Omicron BA.1 waves in The Gambia. Nature Communications, 15(1). View this article in WRRO
Hornsby H, Nicols AR, Longet S, Liu C, Tomic A, Angyal A, Kronsteiner B, Tyerman JK, Tipton T, Zhang P , Gallis M et al (2023) Omicron infection following vaccination enhances a broad spectrum of immune responses dependent on infection history. Nature Communications, 14(1). View this article in WRRO
Barnes E, Goodyear CS, Willicombe M, Gaskell C, Siebert S, I de Silva T, Murray SM, Rea D, Snowden JA, Carroll M , Pirrie S et al (2023) SARS-CoV-2-specific immune responses and clinical outcomes after COVID-19 vaccination in patients with immune-suppressive disease. Nature Medicine, 29(7), 1760-1774. View this article in WRRO
Miller PDE, Patel SR, Skinner R, Dignan F, Richter A, Jeffery K, Khan A, Heath PT, Clark A, Orchard K , Snowden JA et al (2023) Joint consensus statement on the vaccination of adult and paediatric haematopoietic stem cell transplant recipients: prepared on behalf of the British society of blood and marrow transplantation and cellular therapy (BSBMTCT), the Children's cancer and Leukaemia Group (CCLG), and British Infection Association (BIA). Journal of Infection, 86(1), 1-8. View this article in WRRO
Longet S, Hargreaves A, Healy S, Brown R, Hornsby HR, Meardon N, Tipton T, Barnes E, Dunachie S, Duncan CJA , Klenerman P et al (2022) mRNA vaccination drives differential mucosal neutralizing antibody profiles in naïve and SARS-CoV-2 previously-infected individuals. Frontiers in Immunology, 13.
Costa-Martins AG, Mane K, Lindsey BB, Ogava RLT, Castro I, Jagne YJ, Sallah HJ, Armitage EP, Jarju S, Ahadzie B , Ellis-Watson R et al (2022) Prior upregulation of interferon pathways in the nasopharynx impacts viral shedding following live attenuated influenza vaccine challenge in children (vol 2, 100465, 2021). CELL REPORTS MEDICINE, 3(2).
Lindsey BB, Villabona-Arenas CJ, Campbell F, Keeley AJ, Parker MD, Shah DR, Parsons H, Zhang P, Kakkar N, Gallis M , Foulkes BH et al (2022) Characterising within-hospital SARS-CoV-2 transmission events using epidemiological and viral genomic data across two pandemic waves. Nature Communications, 13(1). View this article in WRRO
Angyal A, Longet S, Moore SC, Payne RP, Harding A, Tipton T, Rongkard P, Ali M, Hering LM, Meardon N , Austin J et al (2022) T-cell and antibody responses to first BNT162b2 vaccine dose in previously infected and SARS-CoV-2-naive UK health-care workers: a multicentre prospective cohort study. The Lancet Microbe, 3(1), e21-e31.
Minter A, Hoschler K, Jagne YJ, Sallah H, Armitage E, Lindsey B, Hay JA, Riley S, de Silva TI & Kucharski A (2022) Estimation of seasonal influenza attack rates and antibody dynamics in children using cross-sectional serological data. The Journal of Infectious Diseases, 225(10), 1750-1754.
de Silva TI, Liu G, Lindsey BB, Dong D, Moore SC, Hsu NS, Shah D, Wellington D, Mentzer AJ, Angyal A , Brown R et al (2021) The impact of viral mutations on recognition by SARS-CoV-2 specific T cells. iScience, 24(11). View this article in WRRO
Payne RP, Longet S, Austin JA, Skelly DT, Dejnirattisai W, Adele S, Meardon N, Faustini S, Al-Taei S, Moore SC , Tipton T et al (2021) Immunogenicity of standard and extended dosing intervals of BNT162b2 mRNA vaccine. Cell, 184(23), 5699-5714.e11.
Peno C, Armitage EP, Clerc M, Balcazar Lopez C, Jagne YJ, Drammeh S, Jarju S, Sallah H, Senghore E, Lindsey BB , Camara J et al (2021) The effect of live attenuated influenza vaccine on pneumococcal colonisation densities among children aged 24–59 months in The Gambia: a phase 4, open label, randomised, controlled trial. The Lancet Microbe, 2(12), e656-e665.
Weissman D, Alameh M-G, de Silva T, Collini P, Hornsby H, Brown R, LaBranche CC, Edwards RJ, Sutherland L, Santra S , Mansouri K et al (2021) D614G Spike Mutation Increases SARS CoV-2 Susceptibility to Neutralization. Cell Host & Microbe, 29(1), 23-31.e4.
Korber B, Fischer WM, Gnanakaran S, Yoon H, Theiler J, Abfalterer W, Hengartner N, Giorgi EE, Bhattacharya T, Foley B , Hastie KM et al (2020) Tracking changes in SARS-CoV-2 Spike: evidence that D614G increases infectivity of the COVID-19 virus. Cell, 182(4), 812-827.e19. View this article in WRRO
Armitage EP, Senghore E, Darboe S, Barry M, Camara J, Bah S, Marks M, Cerami C, Roca A, Antonio M , Turner CE et al (2019) High burden and seasonal variation of paediatric scabies and pyoderma prevalence in the Gambia : a cross-sectional study. PLOS Neglected Tropical Diseases, 13(10).
de Lima DS, Cardozo LE, Maracaja-Coutinho V, Suhrbier A, Mane K, Jeffries D, Silveira ELV, Amaral PP, Rappuoli R, de Silva TI & Nakaya HI (2019) Long noncoding RNAs are involved in multiple immunological pathways in response to vaccination. Proceedings of the National Academy of Sciences, 116(34), 17121-17126.
Lindsey BB, Jagne YJ, Armitage EP, Singanayagam A, Sallah HJ, Drammeh S, Senghore E, Mohammed NI, Jeffries D, Höschler K , Tregoning JS et al (2019) Effect of a Russian-backbone live-attenuated influenza vaccine with an updated pandemic H1N1 strain on shedding and immunogenicity among children in The Gambia: an open-label, observational, phase 4 study. The Lancet Respiratory Medicine, 7(8), 665-676.
Lindsey BB, Armitage EP, Kampmann B & de Silva TI (2019) The efficacy, effectiveness, and immunogenicity of influenza vaccines in Africa: a systematic review. Lancet Infectious Diseases, 19(4), e110-e119. View this article in WRRO
de Silva TI, Gould V, Mohammed NI, Cope A, Meijer A, Zutt I, Reimerink J, Kampmann B, Hoschler K, Zambon M & Tregoning JS (2017) Comparison of mucosal lining fluid sampling methods and influenza-specific IgA detection assays for use in human studies of influenza immunity. Journal of Immunological Methods, 449, 1-6.
de Silva TI, Peng Y, Leligdowicz A, Zaidi I, Li L, Griffin H, Blais M-E, Vincent T, Saraiva M, Yindom L-M , van Tienen C et al (2013) Correlates of T-cell–mediated viral control and phenotype of CD8+ T cells in HIV-2, a naturally contained human retroviral infection. Blood, 121(21), 4330-4339.
de Silva TI, Aasa-Chapman M, Cotten M, Hué S, Robinson J, Bibollet-Ruche F, Sarge-Njie R, Berry N, Jaye A, Aaby P , Whittle H et al (2012) Potent Autologous and Heterologous Neutralizing Antibody Responses Occur in HIV-2 Infection across a Broad Range of Infection Outcomes. Journal of Virology, 86(2), 930-946.

All publications

Journal articles

Saso A, Fröberg J, Jobe H, Eleveld M, Okoye M, Kanteh E, Arns A, van Opzeeland F, Kumado M, Faal A , Roberts E et al (2026) Mucosal immune responses to Bordetella pertussis in Gambian infants after maternal and primary vaccination: an immunological substudy of a single-centre, randomised, controlled, double-blind, phase 4 trial. The Lancet Microbe, 7(1), 101219-101219.
Bah SY, Khalid H, Jabang S, Chaudhuri RR, Tilley L, Green LR, Partridge D, de Silva TI & Turner CE (2026) Molecular analysis of Lancefield group C/G streptococci causing human infections in Sheffield, UK. Microbial Genomics, 12(5). View this article in WRRO
Walsh JML, Juttukonda LJ, Tang Y, Chatterjee A, Elosua-Bayes M, Langan E, Frischmann A, Taliaferro F, Matthews HR, Kimler K , Lent CM et al (2026) Unique nasal cell states induced by common pediatric respiratory viruses.
Townsley H, Locke T, Laundy N, Keil C, Keeley AJ, Hamilton J, Pandor A, Darton T & de Silva TI (2025) A systematic review of asymptomatic colonisation with Group A Streptococcus in lower and middle income countries. Journal of Infection. View this article in WRRO
Hodgson D, Hay J, Jarju S, Jobe D, Wenlock R, de Silva TI & Kucharski AJ (2025) serojump: a Bayesian tool for inferring infection timing and antibody kinetics from longitudinal serological data. PLoS Computational Biology, 21(9). View this article in WRRO
Sanyang B, Dabrowska MB, Amenyogbe N, Camara B, Beloum N, Jammeh M, Bojang D, Goodall J, Mohammed N, Sesay AK , Roca A et al (2025) Effect of intrapartum azithromycin on early childhood gut mycobiota development: post hoc analysis of a double-blind randomized trial. Nature Communications, 16. View this article in WRRO
Keeley AJ, Camara FE, Armitage EP, de Crombrugghe G, Sillah J, Fofana ML, Rollinson V, Senghore E, Jammeh M, Whitcombe AL , Bittaye A et al (2025) Early-life serological profiles and the development of natural protective humoral immunity to Streptococcus pyogenes in a high-burden setting. Nature Medicine, 31(10), 3360-3371. View this article in WRRO
McLornan DP, Hazenberg MD, Ciceri F, Alexander T, Angelucci E, Averbuch D, Bazarbachi A, Chakraverty R, Booth C, Heemskerk MHM , Holler E et al (2025) Advancing the integration of ‘basic/fundamental’ and translational cellular and gene therapy science within the EBMT: Accelerating the pathway to progress. Bone Marrow Transplantation. View this article in WRRO
Symes R, Keddie SH, Walker J, McKeever T, Ahmad S, Arnold D, Evans CM, Pelosi E, Rahman NM, Sapey E , Zambon M et al (2025) Burden of respiratory syncytial virus infection in older adults hospitalised in England during 2023/24. Journal of Infection, 91(3), 106570-106570.
Hao S, Tomic I, Lindsey BB, Jagne YJ, Hoschler K, Meijer A, Carreño Quiroz JM, Meade P, Sano K, Peno C , Costa-Martins AG et al (2025) Integrative mapping of pre-existing influenza immune landscapes predicts vaccine response. Journal of Clinical Investigation, 135(18). View this article in WRRO
Armitage EP, Senghore E, Camara FE, Jarju S, Jagne S, Ceesay E, Darboe FF, de Crombrugghe G, Keeley AJ, Hall JN , Angyal A et al (2025) Evaluating clinical decision rules and rapid diagnostic tests for the diagnosis of Streptococcus pyogenes pharyngitis in Gambian children: A diagnostic accuracy study. Journal of Infection, 91(2), 106546-106546.
Carreño JM, Meade P, Sogodogo NF, Sano K, Tcheou J, Raskin A, Singh G, Fried M, Loganathan M, Francis B , Bielak D et al (2025) Induction of hemagglutinin stalk reactive antibodies by the administration of a live-attenuated influenza virus vaccine in children. iScience, 28(7), 112893-112893.
Jagne YJ, Jobe D, Darboe A, Danso M, Barratt N, Gomez M, Wenlock R, Jarju S, Sylva EL, Touray AF , Toure F et al (2025) Compartmentalised mucosal and blood immunity to SARS-CoV-2 is associated with high seroprevalence before the Delta wave in Africa. Communications Medicine, 5(1). View this article in WRRO
de Crombrugghe G, Armitage EP, Keeley AJ, Senghore E, Camara F, Jammeh M, Bittaye A, Ceesay H, Ceesay I, Samateh B , Manneh M et al (2025) Household Molecular Epidemiology of Streptococcus pyogenes Carriage and Infection in The Gambia. The Journal of Infectious Diseases, 232(3), 550-559.
Chen J-L, Wang B, Lu Y, Antoun E, Bird O, Drennan PG, Yin Z, Liu G, Yao X, Pidoux M , Bates A et al (2025) T cell memory response to MPXV infection exhibits greater effector function and migratory potential compared to MVA-BN vaccination. Nature Communications, 16. View this article in WRRO
Pagano L, Maschmeyer G, Lamoth F, Blennow O, Xhaard A, Spadea M, Busca A, Cordonnier C, Maertens J, Guisado MA , Akova M et al (2025) Primary antifungal prophylaxis in hematological malignancies. Updated clinical practice guidelines by the European Conference on Infections in Leukemia (ECIL). Leukemia, 39, 1547-1557. View this article in WRRO
Saso A, Kanteh E, Jeffries D, Okoye M, Mohammed N, Kumado M, Roetynck S, Jobe H, Faal A, Roberts E , Gageldonk P et al (2025) The effect of pertussis vaccination in pregnancy on the immunogenicity of acellular or whole-cell pertussis vaccination in Gambian infants (GaPS): a single-centre, randomised, controlled, double-blind, phase 4 trial. The Lancet Infectious Diseases, 25(8), 909-924.
Mellors J, Dhaliwal R, Longet S, Tipton T, McInnes I, Siebert S, Kearns P, Rea D, Cook G, Willicombe M , Thomas D et al (2025) Complement-mediated enhancement of SARS-CoV-2 antibody neutralisation potency in vaccinated individuals. Nature Communications, 16(1). View this article in WRRO
Locke TE, Keeley AJ, Laundy N, Keil C, Hamilton J, Pandor A, I de Silva T & Darton TC (2025) Prevalence and risk factors for Staphylococcus aureus colonisation among healthy individuals in low- and middle-income countries: a systematic review and meta-analysis. Journal of Infection, 90(4). View this article in WRRO
Peno C, Jagne YJ, Clerc M, Balcazar Lopez C, Armitage EP, Sallah H, Drammeh S, Senghore E, Goderski G, van Tol S , Meijer A et al (2025) Interactions between live attenuated influenza vaccine and nasopharyngeal microbiota among children aged 24–59 months in The Gambia: a phase 4, open-label, randomised controlled trial. The Lancet Microbe, 6(3), 100971-100971.
Massai L, Carducci M, Rovetini L, Paterson A, Whitcombe A, McGregor R, Lorenz N, Keeley AJ, de Silva TI, Bennett J , Berlanda Scorza F et al (2025) Characterization of an IL-8 cleavage inhibition assay to determine the functionality of anti-SpyCEP antibodies in human sera. Journal of Immunological Methods, 536, 113786-113786.
Hall JN, Armitage EP, Senghore E, Darboe S, Barry M, Camara J, Bah S, Keeley AJ, McCarthy JS, Smeesters P , Turner CE et al (2025) Molecular methods enhance the detection of pyoderma-related Streptococcus pyogenes and emm-type distribution in children. The Journal of Infectious Diseases, 231(1), e28-e37. View this article in WRRO
Locke T, Siribaddana S, Jayaweera JAAS, Suligoy CM, de Silva TI, Corrigan RM & Darton TC (2024) A prospective cohort study to investigate the transmission and burden of Staphylococcus aureus in Sri Lanka. Microbial Genomics, 10(12). View this article in WRRO
Colton H, Barratt N, Temperton N, Hornsby H, Angyal A, Grouneva I, Lindsey BB, Kearns P, Barnes E, Goodyear CS , Richter A et al (2024) Greater preservation of SARS‐CoV‐2 neutralising antibody responses following the ChAdOx1‐S (AZD1222) vaccine compared with mRNA vaccines in haematopoietic cell transplant recipients. British Journal of Haematology, 205(6), 2206-2218. View this article in WRRO
Saville TJ, Colton H, Jarju S, Armitage EP, Drammeh S, Tazzyman S, Jagne YJ, Sallah HJ, Senghore E, Evans CM , Darton TC et al (2024) Microfluidic qPCR for detection of 21 common respiratory viruses in children with influenza-like illness. Scientific Reports, 14(1). View this article in WRRO
Wiseman JP, Scarrott JM, Alves-Cruzeiro J, Saffari A, Böger C, Karyka E, Dawes E, Davies AK, Marchi PM, Graves E , Fernandes F et al (2024) Pre-clinical development of AP4B1 gene replacement therapy for hereditary spastic paraplegia type 47. EMBO Molecular Medicine, 16(11), 2882-2917. View this article in WRRO
Hall JN, Bah SY, Khalid H, Brailey A, Coleman S, Kirk T, Hussain N, Tovey M, Chaudhuri RR, Davies S , Tilley L et al (2024) Molecular characterization of Streptococcus pyogenes (StrepA) non-invasive isolates during the 2022–2023 UK upsurge. Microbial Genomics, 10(8). View this article in WRRO
Galgut O, Ashford F, Deeks A, Ghataure A, Islam M, Sambhi T, Ker YW, Duncan CJA, de Silva TI, Hopkins S , Hall V et al (2024) COVID-19 vaccines are effective at preventing symptomatic and severe infection among healthcare workers: A clinical review. Vaccine: X, 20, 100546-100546.
Sanyang B, de Silva TI, Camara B, Beloum N, Kanteh A, Manneh J, de Steenhuijsen Piters WAA, Bogaert D, Sesay AK & Roca A (2024) Effect of intrapartum azithromycin on gut microbiota development in early childhood: A post hoc analysis of a double-blind randomized trial. iScience, 27(9), 110626-110626.
Brudenell EL, Pohare MB, Zafred D, Phipps J, Hornsby HR, Darby JF, Dai J, Liggett E, Cain KM, Barran PE , de Silva TI et al (2024) Efficient overexpression and purification of severe acute respiratory syndrome coronavirus 2 nucleocapsid proteins in Escherichia coli. Biochemical Journal, 481(11), 669-682. View this article in WRRO
Armitage EP, de Crombrugghe G, Keeley AJ, Senghore E, Camara FE, Jammeh M, Bittaye A, Ceesay H, Ceesay I, Samateh B , Manneh M et al (2024) Streptococcus pyogenes carriage and infection within households in The Gambia: a longitudinal cohort study. The Lancet Microbe, 5(7), 679-688.
Liu C, Zhou D, Dijokaite-Guraliuc A, Supasa P, Duyvesteyn HME, Ginn HM, Selvaraj M, Mentzer AJ, Das R, de Silva TI , Ritter TG et al (2024) A structure-function analysis shows SARS-CoV-2 BA.2.86 balances antibody escape and ACE2 affinity. Cell Reports Medicine, 5(5), 101553-101553.
Goodyear CS, Patel A, Barnes E, Willicombe M, Siebert S, de Silva TI, Snowden JA, Lim SH, Bowden SJ, Billingham L , Richter A et al (2024) Immunogenicity of third dose COVID-19 vaccine strategies in patients who are immunocompromised with suboptimal immunity following two doses (OCTAVE-DUO): an open-label, multicentre, randomised, controlled, phase 3 trial. The Lancet Rheumatology, 6(6), e339-e351. View this article in WRRO
Jarju S, Wenlock RD, Danso M, Jobe D, Jagne YJ, Darboe A, Kumado M, Jallow Y, Touray M, Ceesay EA , Gaye H et al (2024) High SARS-CoV-2 incidence and asymptomatic fraction during Delta and Omicron BA.1 waves in The Gambia. Nature Communications, 15(1). View this article in WRRO
Ali M, Longet S, Neale I, Rongkard P, Chowdhury FUH, Hill J, Brown A, Laidlaw S, Tipton T, Hoque A , Hassan N et al (2024) Obesity differs from diabetes mellitus in antibody and T-cell responses post-COVID-19 recovery. Clinical and Experimental Immunology, 218(1), 78-92. View this article in WRRO
Liew F, Efstathiou C, Fontanella S, Richardson M, Saunders R, Swieboda D, Sidhu JK, Ascough S, Moore SC, Mohamed N , Nunag J et al (2024) Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease. Nature Immunology, 25(4), 607-621. View this article in WRRO
Suau Sans M, Manneh M, Ceesay I, Bittaye A, de Crombrugghe G, Keeley AJ, de Silva TI, Palmer J, Armitage EP & Marks M (2024) Health-seeking behaviour and beliefs around sore throat in The Gambia: A qualitative study. PLOS Global Public Health, 4(3). View this article in WRRO
Brittain G, Petrie J, Duffy KEM, Glover R, Hullock K, Papaioannou D, Roldan E, Beecher C, Bursnall M, Ciccarelli O , Coles AJ et al (2024) Efficacy and safety of autologous haematopoietic stem cell transplantation versus alemtuzumab, ocrelizumab, ofatumumab or cladribine in relapsing remitting multiple sclerosis (StarMS): protocol for a randomised controlled trial. BMJ Open, 14(2). View this article in WRRO
Carducci M, Whitcombe A, Rovetini L, Massai L, Keeley AJ, de Silva TI, Bennett J, Berlanda Scorza F, Iturriza M, Moreland NJ , Moriel DG et al (2024) Development and characterization of a hemolysis inhibition assay to determine functionality of anti-Streptolysin O antibodies in human sera. Journal of Immunological Methods, 526, 113618-113618.
Sidhu JK, Siggins MK, Liew F, Russell CD, Uruchurtu ASS, Davis C, Turtle L, Moore SC, Hardwick HE, Oosthuyzen W , Thomson EC et al (2024) Delayed mucosal antiviral responses despite robust peripheral inflammation in fatal COVID-19. The Journal of Infectious Diseases, 230(1), e17-e29. View this article in WRRO
Gupta V, Kariotis S, Rajab MD, Errington N, Alhathli E, Jammeh E, Brook M, Meardon N, Collini P, Cole J , Wild JM et al (2023) Unsupervised machine learning to investigate trajectory patterns of COVID-19 symptoms and physical activity measured via the MyHeart Counts App and smart devices. npj Digital Medicine, 6. View this article in WRRO
Hall J, Angyal A, Armitage E, Senghore E, Darboe S, Barry M, Camara J, Bah S, Keeley A, McCarthy J , Turner C et al (2023) 44 Quantitative PCR demonstrates the underestimated burden of Streptococcus pyogenes as a cause of paediatric pyoderma in The Gambia. Clinical Infection in Practice, 20(Supplement 1). View this article in WRRO
Armitage EP, Keeley AJ, de Crombrugghe G, Senghore E, Camara FE, Jammeh M, Bittaye A, Ceesay H, Ceesay I, Samateh B , Manneh M et al (2023) Streptococcus pyogenes carriage acquisition, persistence and transmission dynamics within households in The Gambia (SpyCATS): protocol for a longitudinal household cohort study. Wellcome Open Research, 8. View this article in WRRO
Neale I, Ali M, Kronsteiner B, Longet S, Abraham P, Deeks AS, Brown A, Moore SC, Stafford L, Dobson SL , Plowright M et al (2023) CD4+ and CD8+ T cells and antibodies are associated with protection against Delta vaccine breakthrough infection: a nested case-control study within the PITCH study. mBio, 14(5). View this article in WRRO
Hornsby H, Nicols AR, Longet S, Liu C, Tomic A, Angyal A, Kronsteiner B, Tyerman JK, Tipton T, Zhang P , Gallis M et al (2023) Omicron infection following vaccination enhances a broad spectrum of immune responses dependent on infection history. Nature Communications, 14(1). View this article in WRRO
Barnes E, Goodyear CS, Willicombe M, Gaskell C, Siebert S, I de Silva T, Murray SM, Rea D, Snowden JA, Carroll M , Pirrie S et al (2023) SARS-CoV-2-specific immune responses and clinical outcomes after COVID-19 vaccination in patients with immune-suppressive disease. Nature Medicine, 29(7), 1760-1774. View this article in WRRO
Asante IA, Hsu SN, Boatemaa L, Kwasah L, Adusei-Poku M, Odoom JK, Awuku-Larbi Y, Foulkes BH, Oliver-Commey J, Asiedu EK , Parker MD et al (2023) Repurposing an integrated national influenza platform for genomic surveillance of SARS-CoV-2 in Ghana: a molecular epidemiological analysis. The Lancet Global Health, 11(7), e1075-e1085. View this article in WRRO
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Knight GM, Clarkson M & de Silva TI (2018) Potential impact of influenza vaccine roll-out on antibiotic use in Africa. Journal of Antimicrobial Chemotherapy, 73(8), 2197-2200. View this article in WRRO
de Silva T, Leligdowicz A, Carlson J, Garcia-Knight M, Onyango C, Miller N, Yindom LM, Hue S, Jaye A, Dong T , Cotten M et al (2018) HLA-associated polymorphisms in the HIV-2 capsid highlight key differences between HIV-1 and HIV-2 immune adaptation.. AIDS, 32(6), 709-714. View this article in WRRO
Armitage EP, Camara J, Bah S, Forster AS, Clarke E, Kampmann B & de Silva TI (2018) Acceptability of intranasal live attenuated influenza vaccine, influenza knowledge and vaccine intent in The Gambia. Vaccine, 36(13), 1772-1780.
de Silva TI, Gould V, Mohammed NI, Cope A, Meijer A, Zutt I, Reimerink J, Kampmann B, Hoschler K, Zambon M & Tregoning JS (2017) Comparison of mucosal lining fluid sampling methods and influenza-specific IgA detection assays for use in human studies of influenza immunity. Journal of Immunological Methods, 449, 1-6.
de Silva TI & Kampmann B (2017) Value of immunogenicity studies of influenza vaccine in resource-limited settings. Lancet Global Health, 5(3). View this article in WRRO
Miller PD, de Silva TI, Skinner R, Gilleece M, Peniket A, Hamblin A, Greenfield D, Anthias C, Peggs K, Madrigal A & Snowden JA (2017) Routine vaccination practice after adult and paediatric allogeneic haematopoietic stem cell transplant: a survey of UK NHS programmes.. Bone Marrow Transplant.
Parkash V, Mudhar HS, Wagner BE, Raoult D, Batty R, Lepidi H, Burke J, Collini P & de Silva T (2016) Bilateral Ocular Myositis Associated with Whipple's Disease. Ocular Oncology and Pathology, 3, 17-21. View this article in WRRO
Garcia-Knight MA, Slyker J, Payne BL, Pond SLK, de Silva TI, Chohan B, Khasimwa B, Mbori-Ngacha D, John-Stewart G, Rowland-Jones SL & Esbjörnsson J (2016) Viral Evolution and Cytotoxic T Cell Restricted Selection in Acute Infant HIV-1 Infection. Scientific Reports, 6. View this article in WRRO
Fryer HR, Van Tienen C, Van Der Loeff MS, Aaby P, Da Silva ZJ, Whittle H, Rowland-Jones SL & de Silva TI (2015) Predicting the extinction of HIV-2 in rural Guinea-Bissau. AIDS, 29(18), 2479-2486. View this article in WRRO
Yindom L, James K, de Silva TI & Rowland‐Jones SL (2015) KIR3DL1*0040102 – a novel three‐domain KIR subtype isolated from donors of African descent. Tissue Antigens, 86(3), 220-221.
Yindom L, de Silva TI & Rowland‐Jones SL (2015) Full‐length sequence of KIR3DL1*0310102 detected in DNA samples from West Africa. Tissue Antigens, 86(4), 312-313.
Yindom L, de Silva TI & Rowland‐Jones SL (2015) KIR3DL1*0250103: a novel three‐domain KIR allele isolated in West African samples. Tissue Antigens, 86(2), 150-151.
Yindom L, James K, de Silva TI & Rowland‐Jones SL (2015) A novel KIR3DL1*0150103 subtype identified in West Africa. Tissue Antigens, 86(1), 70-71.
Yindom L, de Silva TI & Rowland‐Jones SL (2015) Identification of a novel three‐domain KIR allele: KIR3DL1*087 using high‐resolution molecular techniques. Tissue Antigens, 85(2), 153-154.
Yindom L, de Silva TI & Rowland‐Jones SL (2015) KIR3DL1*0250102: a novel three‐domain KIR subtype identified in West Africa. Tissue Antigens, 85(2), 151-152.
de Silva TI, Debroy Kidambi A, Green ST, Mahadeva U, Mcgregor AC, Levy M & Hardcastle N (2015) Cutaneous leishmaniasis acquired during a brief visit to Cyprus. Journal of Infection, 70(3), 314-316.
Yindom L, Wong G, de Silva TI & Rowland‐Jones SL (2014) Complete genomic sequence of KIR3DL1*0150102. Tissue Antigens, 84(6), 595-596.
Yindom L, de Silva TI & Rowland‐Jones SL (2014) Description of a novel KIR3DL1*0150211 allele isolated using molecular techniques. Tissue Antigens, 84(6), 596-597.
Yindom L, James K, de Silva TI & Rowland‐Jones SL (2014) Isolation of full‐length genomic sequences of the KIR3DL1*0040103 allele from African donors using sequence‐based techniques. Tissue Antigens, 84(6), 594-595.
Yindom L, Wong G, de Silva TI & Rowland‐Jones SL (2014) A new variant of killer‐cell immunoglobulin‐like receptor KIR3DL1*03101 isolated using sequence‐based techniques. Tissue Antigens, 84(5), 521-522.
Yindom L, James K, de Silva TI & Rowland‐Jones SL (2014) Genomic full length sequence of a novel killer‐cell immunoglobulin‐like receptor, KIR3DL1*0010103 identified by sequencing. Tissue Antigens, 84(5), 520-521.
Yindom L, James K, de Silva TI & Rowland‐Jones SL (2014) Full‐length KIR3DL1*022 detected in an African donor. Tissue Antigens, 84(4), 427-429.
Uchtenhagen H, Schiffner T, Bowles E, Heyndrickx L, LaBranche C, Applequist SE, Jansson M, De Silva T, Back JW, Achour A , Scarlatti G et al (2014) Boosting of HIV-1 Neutralizing Antibody Responses by a Distally Related Retroviral Envelope Protein. The Journal of Immunology, 192(12), 5802-5812.
de Silva TI, Green ST, Cole J, Stone BJ, Dockrell DH & Vedio AB (2014) Successful use of Fendrix in HIV-infected non-responders to standard hepatitis B vaccines. Journal of Infection, 68(4), 397-399.
Yindom L, de Silva TI & Rowland‐Jones SL (2014) A novel KIR3DL1*0200102 allele isolated from a West African donor by sequence‐based typing. Tissue Antigens, 83(4), 305-306.
Yindom L, de Silva TI & Rowland‐Jones SL (2014) Full‐length sequence of KIR3DL1*01501 allele found in Sub‐Saharan Africa by long‐range sequencing. Tissue Antigens, 83(2), 126-127.
de Silva T, Peng Y, Leligdowicz A, Zaidi I, Li L, Griffin H, Blais M-E, Vincent T, Saraiva M, Yindom L-M , van Tienen C et al (2013) The role of CD8+ T-cell responses in the pathogenesis of HIV-2, a naturally contained human retroviral infection. Journal of Infection, 67(4), 344-344.
de Silva TI, Peng Y, Leligdowicz A, Zaidi I, Li L, Griffin H, Blais M-E, Vincent T, Saraiva M, Yindom L-M , van Tienen C et al (2013) Correlates of T-cell–mediated viral control and phenotype of CD8+ T cells in HIV-2, a naturally contained human retroviral infection. Blood, 121(21), 4330-4339.
de Silva TI, van Tienen C, Onyango C, Jabang A, Vincent T, Loeff MFSVD, Coutinho RA, Jaye A, Rowland-Jones S, Whittle H , Cotten M et al (2013) Population dynamics of HIV-2 in rural West Africa. AIDS, 27(1), 125-134.
Vannberg FO, McDermid JM, Jaye A, MRC Gambia HIV Clinical Cohort Study & Wellcome Trust Case Control Consortium 3 (2012) Effect of HIV-2 infection on HIV-1 disease progression.. N Engl J Med, 367(20), 1962.
(2012) Effect of HIV-2 Infection on HIV-1 Disease Progression. New England Journal of Medicine, 367(20), 1961-1963.
Daigneault M, De Silva TI, Bewley MA, Preston JA, Marriott HM, Mitchell AM, Mitchell TJ, Read RC, Whyte MKB & Dockrell DH (2012) Monocytes Regulate the Mechanism of T-cell Death by Inducing Fas-Mediated Apoptosis during Bacterial Infection. PLoS Pathogens, 8(7). View this article in WRRO
Zaidi I, Peterson K, Jeffries D, Whittle H, de Silva T, Rowland-Jones S, Jaye A & de Jong BC (2012) Immune reconstitution inflammatory syndrome and the influence of T regulatory cells: a cohort study in the Gambia. PLoS ONE, 7(6). View this article in WRRO
van Tienen C, de Silva TI, Junior Alcantara LC, Onyango CO, Jarju S, Goncalves N, Vincent T, Aaby P, Whittle H, van der Loeff MS & Cotten M (2012) Molecular epidemiology of endemic Human T-Lymphotropic virus type 1 in a rural community in Guinea-Bissau. PLoS Neglected Tropical Diseases, 6(6). View this article in WRRO
van Tienen C, McConkey SJ, de Silva TI, Cotten M, Kaye S, Sarge-Njie R, da Costa C, Gonçalves N, Parker J, Vincent T , Jaye A et al (2012) Maternal Proviral Load and Vertical Transmission of Human T Cell Lymphotropic Virus Type 1 in Guinea-Bissau. AIDS Research and Human Retroviruses, 28(6), 584-590.
Sabbah S, Jagne YJ, Zuo J, de Silva T, Ahasan MM, Brander C, Rowland-Jones S, Flanagan KL & Hislop AD (2012) T-cell immunity to Kaposi sarcoma–associated herpesvirus: recognition of primary effusion lymphoma by LANA-specific CD4+ T cells. Blood, 119(9), 2083-2092.
de Silva TI, Aasa-Chapman M, Cotten M, Hué S, Robinson J, Bibollet-Ruche F, Sarge-Njie R, Berry N, Jaye A, Aaby P , Whittle H et al (2012) Potent Autologous and Heterologous Neutralizing Antibody Responses Occur in HIV-2 Infection across a Broad Range of Infection Outcomes. Journal of Virology, 86(2), 930-946.
Stewart B, Jobarteh ML, Sarge-Njie R, Alabi A, de Silva T, Peterson K, Peterson I, Whittle H, Rowland-Jones S, Jaye A , Cotten M et al (2011) Emergence of HBV resistance to lamivudine (3TC) in HIV/HBV co-infected patients in The Gambia, West Africa.. BMC Research Notes, 4. View this article in WRRO
van Tienen C, van der Loeff MS, Peterson I, Cotten M, Andersson S, Holmgren B, Vincent T, de Silva T, Rowland-Jones S, Aaby P & Whittle H (2011) HTLV-1 and HIV-2 Infection Are Associated with Increased Mortality in a Rural West African Community. PLoS ONE , 6(12). View this article in WRRO
Peterson I, Togun O, de Silva T, Oko F, Rowland-Jones S, Jaye A & Peterson K (2011) Mortality and immunovirological outcomes on antiretroviral therapy in HIV-1 and HIV-2-infected individuals in the Gambia. AIDS, 25(17), 2167-2175.
van Tienen C, de Silva TI, Alcantara LC, van der Loeff MS, Vincent T, Gonçalves N, Coutinho RA, Aaby P, Whittle H & Cotten M (2011) Molecular epidemiology of endemic Human T-Lymphotropic virus 1 (HTLV-1) in a community in rural Guinea-Bissau. Retrovirology, 8(S1).
van Tienen C, McConkey SJ, de Silva TI, Cotten M, Kaye S, Sarge-Njie R, da Costa C, Gonçalves N, Parker J, Vincent T , Jaye A et al (2011) Maternal proviral load and vertical transmission of Human T cell Lymphotropic Virus type 1 in Guinea-Bissau. Retrovirology, 8(S1).
Peterson K, Jallow S, Rowland-Jones SL & de Silva TI (2011) Antiretroviral Therapy for HIV-2 Infection: Recommendations for Management in Low-Resource Settings. AIDS Research and Treatment, 2011. View this article in WRRO
de Silva T & Weiss RA (2010) HIV-2 goes global: An unaddressed issue in Indian anti-retroviral programmes. Indian Journal of Medical Research, 132(12), 660-662.
de Silva TI, Turner R, Hue S, Trikha R, van Tienen C, Onyango C, Jaye A, Foley B, Whittle H, Rowland-Jones SL & Cotten M (2010) HIV-1 subtype distribution in the Gambia and the significant presence of CRF49_cpx, a novel circulating recombinant form. Retrovirology, 7. View this article in WRRO
Onyango CO, Leligdowicz A, Yokoyama M, Sato H, Song H, Nakayama EE, Shioda T, de Silva T, Townend J, Jaye A , Whittle H et al (2010) HIV-2 capsids distinguish high and low virus load patients in a West African community cohort. Vaccine, 28, B60-B67.
de Silva TI, van Tienen C, Rowland-Jones SL & Cotten M (2010) Dual Infection with Hiv-1 and Hiv-2: Double Trouble or Destructive Interference?. HIV Therapy, 4(3), 305-323.
Jallow S, Vincent T, Leligdowicz A, De Silva T, Van Tienen C, Alabi A, Sarge‐Njie R, Aaby P, Corrah T, Whittle H , Jaye A et al (2009) Presence of a Multidrug‐Resistance Mutation in an HIV‐2 Variant Infecting a Treatment‐Naive Individual in Caio, Guinea Bissau. Clinical Infectious Diseases, 48(12), 1790-1793.
Stone B, Patel TG, De Silva TI, Green ST & Chapman ALN (2008) Successful treatment of actinomyces brain abscesses using once daily parenteral ceftriaxone in an outpatient setting: a case series. Journal of Infection, 57(5), 426-427.
de Silva TI, Cotten M & Rowland-Jones SL (2008) HIV-2: the forgotten AIDS virus. Trends in Microbiology, 16(12), 588-595.
Rowland-Jones S & de Silva T (2008) Resisting immune exhaustion in HIV-1 infection. PLOS MEDICINE, 5(5), 721-724. View this article in WRRO
de Silva T, Kudesia G, Joall A, Whittaker D, Ryan C & Davies S (2007) The significance of low-positive MOTA scoresin the BD-ProbeTec-Strand Displacement Amplification test for the detection of Neisseria gonorrhoeae. Journal of Infection, 55(3), e67-e68.
de Silva T, Thickett K & Winstanley T (2007) Screening for Extended-Spectrum Beta Lactamase producing gram-negative organisms: can the sensitivity and specificity of current guidance be improved?. Journal of Infection, 55(3), e58-e58.
de Silva TI, Post FA, Griffin MD & Dockrell DH (2007) HIV-1 infection and the kidney: an evolving challenge in HIV medicine. Mayo Clinic proceedings, 82(9), 1103-1116. View this article in WRRO
de Silva TI, Cope A, Goepel J & Greig JM (2007) The use of adjuvant granulocyte-macrophage colony-stimulating factor in HIV-related disseminated atypical mycobacterial infection. Journal of Infection, 54(4), e207-e210.
de Silva T, Evans C, Mudhar HS, Rennie I & Green ST (2006) Isolated endogenous endophthalmitis secondary to Nocardia spp in an immunocompetent adult: Figure 1. Journal of Clinical Pathology, 59(11), 1226.1-1226.
de Silva T, Kudesia G, Joall A, Whittaker D, Davies S & Ryan C (2006) Significance of Low Positive Scores Obtained with a Method Other than Acceleration in the BDProbeTec-Strand Displacement Amplification Test for Detection ofNeisseria gonorrhoeae. Journal of Clinical Microbiology, 44(12), 4628-4629.
Raychaudhuri M, de Silva T, Connor S & Poulton M (2006) Haemorrhagic acute disseminated encephalomyelitis: an unusual case of blindness in an HIV-infected patient. International Journal of STD & AIDS, 17(7), 495-497.
Chapman AL, Kudesia G, McKendrick MW & de Silva TI (2006) WITHDRAWN: Ongoing queries: Interpretation of serology in asymptomatic or atypical chronic Q fever. Journal of Infection.
Evans CM, Mudhar H, Rennie I, Green ST & de Silva TI (2006) WITHDRAWN: Spontaneous resolution of endophthalmitis due to nocardia species. Journal of Infection.
de Silva T, Chapman A, Kudesia G & McKendrick M (2006) Ongoing queries: Interpretation of serology in asymptomatic or atypical chronic Q fever. Journal of Infection, 52(4), e113-e116.
de Silva T (2005) Ventriculitis and hydrocephalus: an unusual presentation of toxoplasmosis in an adult with human immunodeficiency virus. Journal of Neurology, Neurosurgery & Psychiatry, 76(8), 1074-1074.
de Silva T (2005) HIV infection associated with Strongyloides stercoralis colitis resulting in Streptococcus bovis bacteraemia and meningitis. Sexually Transmitted Infections, 81(3), 276-277.
Schmidt-Hieber M, Velasco R, Penack O, Averbuch D, Balaguer-Roselló A, Baccelli F, Bataller L, Cesaro S, Briani C, de la Cámara R , Huehnchen P et al () Central nervous system complications after allogeneic haematopoietic cell transplantation: best practice recommendations from the EBMT practice harmonisation and guidelines committee on epidemiology, outcome and neuroimaging. Bone Marrow Transplantation.
Kronsteiner B, Govender M, Liu C, Dijokaite-Guraliuc A, Ali M, Hill J, Zewdie M, Cross A, Austin J, Watts A , Angyal A et al () Dynamic impact of bivalent COVID-19 vaccine boosters on systemic and mucosal antibody and T cell immunity. Scientific Reports.
Snowden JA, Parkash V, Knelange N, Styczynski J, Tridello G, de Silva T, Niederwieser D, Aljurf M, Sureda A, Mikulska M , de la Camara R et al () Neglected tropical diseases (NTDs) and related infections in hematopoietic cellular therapy (HCT) in adults and children: a survey from the Infectious Diseases Working Party (IDWP) of the European Society of Blood and Marrow Transplantation (EBMT). Bone Marrow Transplantation.
Keeley AJ, Camara FE, Armitage EP, de Crombrugghe G, Sillah J, Fofana ML, Rollinson V, Senghore E, Jammeh M, Whitcombe AL , Bittaye A et al () Publisher Correction: Early-life serological profiles and the development of natural protective humoral immunity to Streptococcus pyogenes in a high-burden setting. Nature Medicine.
Michael BD, Dunai C, Needham EJ, Tharmaratnam K, Williams R, Huang Y, Boardman SA, Clark JJ, Sharma P, Subramaniam K , Wood GK et al () Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses. Nature Communications, 15(1).
Lindsey B, Jagne YJ, Armitage E, Singanayagam A, Sallah H, Drammeh S, Senghore E, Mohammed N, Jeffries D, Höschler K , Tregoning J et al () The impact of an updated pandemic H1N1 strain on shedding and immunogenicity to Russian-backbone live attenuated influenza vaccine among children in The Gambia: an open-label, observational, phase 4 study. The Lancet Respiratory Medicine.
Miller PDE, Forster AS, de Silva TI, Leonard H, Anthias C, Mayhew M, Klammer M, Paskar S, Hurst E, Peggs K , Madrigal A et al () Sociodemographic and psychological determinants of influenza vaccine intention among recipients of autologous and allogeneic haematopoietic stem cell transplant: a cross-sectional survey of UK transplant recipients using a modified health belief model. BMJ OPEN, 8(8). View this article in WRRO
Rowland-Jones S & de Silva T () Correction: Resisting Immune Exhaustion in HIV-1 Infection. PLoS Medicine, 5(6), e134-e134.
Shankar S, Beckett J, Tipton T, Ogbe A, Kasanyinga M, Dold C, Lumley S, Dengu F, Rompianesi G, Elgilani F , Longet S et al () Poor Antibody Responses to SARS-CoV-2 Infection or Vaccination Are Associated With High Re-Infection Rates in Haemodialysis and Renal Transplant Patients.
Kearns P, Siebert S, willicombe M, Gaskell C, Kirkham A, Pirrie S, Bowden S, Magwaro S, Hughes A, Lim Z , Dimitriadis S et al () Examining the Immunological Effects of COVID-19 Vaccination in Patients with Conditions Potentially Leading to Diminished Immune Response Capacity – The OCTAVE Trial.
Russell CD, Fairfield CJ, Drake TM, Turtle L, Seaton RA, Wootton DG, Sigfrid L, Harrison EM, Docherty A, de Silva TI , Egan C et al () Co-Infections, Secondary Infections, and Antimicrobial Usage in Hospitalised Patients with COVID-19 from the ISARIC WHO CCP-UK Study: A Prospective, Multicentre Cohort Study.
Costa-Martins AG, Mane K, Lindsey BB, Ogava RLT, Castro Í, Jagne YJ, Sallah H, Armitage E, Ahadzie B, Ellis-Watson R , Tregoning JS et al () Pre-Existing Upregulation of Interferon Pathways in the Nasopharynx Impacts Viral Shedding Following Live Attenuated Influenza Vaccine Challenge in Children.
Williams DM, Hornsby H, Shehata OM, Brown R, Gallis M, Meardon N, Newman TAH, Plowright M, Zafred D, Shun-Shion ASM , Hodder AJ et al () Characterisation of SARS-CoV-2 Membrane Protein-Specific Antibodies as an Additional Serological Target Following COVID-19 Infections Identified Through a High Content Microscopy-Based Platform.
Jarju S, Wenlock R, Danso M, Jobe D, Jagne YJ, Darboe A, Kumado M, Jallow Y, Touray M, Ceesay EA , Gaye H et al () SARS-CoV-2 Incidence and Re-Infection During Delta and Omicron Ba.1 Waves in the Gambia: Results from a Prospective Household Cohort Study in a Population with Low SARS-CoV-2 Vaccine Coverage.
Goodyear CS, Patel A, Barnes E, willicombe M, Siebert S, de Silva TI, Snowden JA, Lim S, Bowden S, Billingham LJ , Richter AG et al () Immunogenicity of SARSCoV2 Third Dose Vaccine Strategies in Immunocompromised Patients with Suboptimal Immunity Following Two Doses (OCTAVE-DUO): An Open-Label, Multi-Centre, Randomised, Controlled Phase III Trial.

Book chapters

Abrahamian FM, Aldape MJ, Aldasoro E, Allen UD, Al-Sum H, Anadkat MJ, Anders K, Angelakis E, Angus BJ, Antoniadou A , Arena F et al (2017) List of Contributors, Infectious Diseases (pp. xv-xxxvi). Elsevier
De Silva TI & Green ST (2017) Managing the Patient with Recurring Skin Infections, Infectious Diseases (pp. 133-135.e1). Elsevier
Moysi E, de Silva T & Rowland-Jones S (2012) Immune Mechanisms of Viral Control in HIV-2 Infection, Models of Protection Against HIV/SIV (pp. 293-315). Elsevier
Ball TB, Barré-Sinoussi F, Biasin M, Blankson JN, Broliden K, Buckheit RW, Card CM, Clerici M, de Silva T, Fellay J , Fowke KR et al (2012) Contributors, Models of Protection Against HIV/SIV (pp. xi-xii). Elsevier

Conference proceedings

Snowden J, Parkash V, Knelange N, Styczynski J, Tridello G, de Silva T, Niederwieser D, Aljurf M, Sureda A, Mikulska M , de la Camara R et al (2025) NEGLECTED TROPICAL DISEASES (NTD) AND RELATED INFECTIONS IN HAEMATOPOIETIC CELLULAR THERAPY (HCT) IN ADULTS AND CHILDREN: A SURVEY FROM THE EBMT INFECTIOUS DISEASES WORKING PARTY. BONE MARROW TRANSPLANTATION, Vol. 60 (pp 571-572)
Miller PDE, de Silva T, Leonard H, Goddard K, Anthias C, Hoschler K, Peggs K, Madrigal A & Snowden JA (2017) P295: Viral microneutralization assay to determine seasonal influenza vaccine immunogenicity in the first year post reduced intensity conditioning allogeneic HSCT. Bone Marrow Transplantation, Vol. 52(Suppl 1) (pp S269-S270). Marseille, France, 26 March 2017 - 26 March 2017. View this article in WRRO
Miller PDE, de Silva T, Skinner R, Gilleece M, Peniket A, Hamblin A, Greenfield D, Anthias C, Peggs K, Madrigal A & Snowden JA (2016) Routine Vaccination Programme (RVP) Practice after Adult and Paediatric Allogeneic Haematopoietic Stem Cell Transplant (HSCT): A British Society of Blood and Marrow Transplantation (BSBMT) Survey of UK NHS-Based Programmes. BONE MARROW TRANSPLANTATION, Vol. 51 (pp S400-S401)
Meiring J, De Silva T & Snowden J (2015) A study of adherence to a vaccination schedule following adult allogenic haematopoietic stem cell transplants in UK transplant centre. BONE MARROW TRANSPLANTATION, Vol. 50 (pp S203-S204)

Preprints

Hodgson D, Jarju S, Gatcombe L, Coleman T, Dowgier G, Wenlock RD, Lindsey BB, Danso M, Barratt N, Gomes M , Grouneva I et al (2026) Mucosal IgA to pre-fusion F protein predicts protection from RSV infection in a high burden setting, openRxiv.
Bah SY, Khalid H, Jabang S, Chaudhuri R, Tilley L, Green LR, Patridge D, de Silva TI & Turner CE (2026) Molecular analysis of Lancefield group C/G streptococci causing human infections in Sheffield, UK, openRxiv.
Hodgson D, Wenlock RD, Barratt N, Gomes M, Jagne YJ, Jobe D, Jarju S, Danso M, Temperton N, Kampmann B , Flasche S et al (2026) Impact of SARS-CoV-2 exposure history on antibody kinetics and correlates of protection in The Gambia, openRxiv.
Dunachie S, Kronsteiner B, Govender M, Liu C, Dijokaite-Guraliuc A, Hill J, Ali M, Zewdie M, Cross A, Austin J , Watts A et al (2025) Dynamic impact of bivalent COVID-19 vaccine boosters on systemic and mucosal immunity– an observational cohort study, Springer Science and Business Media LLC.
Hodgson D, Hay J, Jarju S, Jobe D, Wenlock R, de Silva TI & Kucharski AJ (2025) serojump: A Bayesian tool for inferring infection timing and antibody kinetics from longitudinal serological data, Cold Spring Harbor Laboratory.
Keeley AJ, Camara FE, Armitage E, de Crombrugghe G, Sillah J, Fofana ML, Rollinson V, Senghore E, Jammeh M, Whitcombe AL , Bittaye A et al (2025) Early life serological profiles and the development of natural protective humoral immunity toStreptococcus pyogenesin a high burden setting, Cold Spring Harbor Laboratory.
Hao S, Tomic I, Lindsey BB, Jagne YJ, Hoschler K, Meijer A, Quiroz JMC, Meade P, Sano K, Peno C , Costa-Martins AG et al (2025) Integrative Mapping of Pre-existing Immune Landscapes for Vaccine Response Prediction, Cold Spring Harbor Laboratory.
JAGNE YJ, Jobe D, Darboe A, Danso M, Barratt N, Gomez M, Wenlock R, Jarju S, Sylva E, Touray AF , Toure F et al (2024) Compartmentalised mucosal and blood immunity to SARS-CoV-2 associated with high seroprevalence before Delta wave in Africa, Springer Science and Business Media LLC.
Hall JN, Bah SY, Khalid H, Brailey A, Coleman S, Kirk T, Hussain N, Tovey M, Chaudhuri RR, Davies S , Tilley L et al (2024) Molecular characterisation ofStreptococcus pyogenes(StrepA) non-invasive isolates during the 2022-23 UK upsurge, Cold Spring Harbor Laboratory.
Hall JN, Armitage EP, Senghore E, Darboe S, Barry M, Camara J, Bah S, Keeley AJ, McCarthy JS, Smeesters P , Turner CE et al (2024) Molecular methods enhance the detection of pyoderma-related Streptococcus pyogenes and emm-type distribution in children, Cold Spring Harbor Laboratory.
Brudenell EL, Pohare MB, Zafred D, Phipps J, Hornsby HR, Darby J, Dai J, Liggett E, Cain K, Barran PE , de Silva TI et al (2024) Efficient overexpression and purification of SARS-CoV-2 Nucleocapsid proteins inEscherichia coli, Cold Spring Harbor Laboratory.
Openshaw P, Liew F, Efstathiou C, Fontanella S, Richardson M, Saunders R, Swieboda D, Sidhu J, Ascough S, Moore S , Mohamed N et al (2023) Large scale phenotyping of long COVID inflammation reveals mechanistic subtypes of disease after COVID-19 hospitalisation, Springer Science and Business Media LLC.
Ali M, Longet S, Neale I, Rongkard P, Chowdhury FUH, Hill J, Brown A, Laidlaw S, Tipton T, Hoque A , Hassan N et al (2023) Obesity Differs from Diabetes Mellitus in Antibody and T Cell Responses Post COVID-19 Recovery, Cold Spring Harbor Laboratory.
Liew F, Efstathiou C, Fontanella S, Richardson M, Saunders R, Swieboda D, Sidhu JK, Ascough S, Moore SC, Mohamed N , Nunag J et al (2023) Large scale phenotyping of long COVID inflammation reveals mechanistic subtypes of disease, Cold Spring Harbor Laboratory.
Neale I, Ali M, Kronsteiner B, Longet S, Abraham P, Deeks AS, Brown A, Moore SC, Stafford L, Dobson SL , Plowright M et al (2023) CD4+ and CD8+ T cell and antibody correlates of protection against Delta vaccine breakthrough infection: A nested case-control study within the PITCH study, Cold Spring Harbor Laboratory.
Hornsby H, Nicols AR, Longet S, Liu C, Tomic A, Angyal A, Kronsteiner B, Tyerman JK, Tipton T, Zhang P , Ramalho MG et al (2023) Omicron BA.1/BA.2 infections in triple-vaccinated individuals enhance a diverse repertoire of mucosal and blood immune responses, Cold Spring Harbor Laboratory.
Bah SY, Kujabi MA, Darboe S, Kebbeh N, Kebbeh BFK, Kanteh A, Bojang R, Lawn JE, Kampmann B, Abdul Karim S , de Silva TI et al (2022) EARLY ACQUISITION AND CARRIAGE OF GENETICALLY DIVERSE MULTI-DRUG RESISTANT GRAM-NEGATIVE BACILLI IN HOSPITALISED SMALL VULNERABLE NEWBORNS IN THE GAMBIA, Cold Spring Harbor Laboratory.
Liew F, Talwar S, Cross A, Willett BJ, Scott S, Logan N, Siggins MK, Swieboda D, Sidhu JK, Efstathiou C , Moore SC et al (2022) Nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination, Cold Spring Harbor Laboratory.
Kanteh A, Jallow HS, Manneh J, Sanyang B, Kujabi MA, Ndure SL, Jarju S, Sey AP, Damilare DK, Bah Y , Sambou S et al (2022) Genomic epidemiology of SARS-CoV-2 infections in The Gambia, March 2020 to Jan 2022, Cold Spring Harbor Laboratory.
Jarju S, Senghore E, Brotherton H, Saidykhan A, Jallow S, Krubally E, Sinjanka E, Ndene MN, Bajo F, Sanyang M , Saidy B et al (2022) Circulation of respiratory viruses during the COVID-19 pandemic in The Gambia, Cold Spring Harbor Laboratory.
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Stirrup OT, Boshier FAT, Venturini C, Guerra-Assunção JA, Alcolea-Medina A, Becket AH, Charalampous T, da Silva Filipe A, Glaysher S, Khan T , Kulasegara-Shylini R et al (2021) SARS-CoV-2 lineage B.1.1.7 is associated with greater disease severity among hospitalised women but not men, Cold Spring Harbor Laboratory.
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Jeewandara C, Jayathilaka D, Ranasinghe D, Hsu NS, Ariyaratne D, Jayadas TT, Madushanka D, Lindsey BB, Gomes L, Parker MD , Wijewickrama A et al (2021) Genomic and epidemiological analysis of SARS-CoV-2 viruses in Sri Lanka, Cold Spring Harbor Laboratory.
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Parker MD, Lindsey BB, Shah DR, Hsu S, Keeley AJ, Partridge DG, Leary S, Cope A, State A, Johnson K , Ali N et al (2021) Altered Subgenomic RNA Expression in SARS-CoV-2 B.1.1.7 Infections, Cold Spring Harbor Laboratory.
Golubchik T, Lythgoe KA, Hall M, Ferretti L, Fryer HR, MacIntyre-Cockett G, de Cesare M, Trebes A, Piazza P, Buck D , Todd JA et al (2021) Early analysis of a potential link between viral load and the N501Y mutation in the SARS-COV-2 spike protein, Cold Spring Harbor Laboratory.
Leclerc QJ, Fuller NM, Keogh RH, Diaz-Ordaz K, Sekula R, Semple MG, Atkins KE, Procter SR & Knight GM (2021) Importance of patient bed pathways and length of stay differences in predicting COVID-19 bed occupancy in England, Cold Spring Harbor Laboratory.
Mashe T, Takawira FT, Martins LDO, Gudza-Mugabe M, Chirenda J, Munyanyi M, Chaibva BV, Tarupiwa A, Gumbo H, Juru A , Nyagupe C et al (2021) Genomic epidemiology of the SARS-CoV-2 epidemic in Zimbabwe: Role of international travel and regional migration in spread, Cold Spring Harbor Laboratory.
Davies NG, Abbott S, Barnard RC, Jarvis CI, Kucharski AJ, Munday JD, Pearson CAB, Russell TW, Tully DC, Washburne AD , Wenseleers T et al (2020) Estimated transmissibility and impact of SARS-CoV-2 lineage B.1.1.7 in England, Cold Spring Harbor Laboratory.
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Jagne I, Keeley AJ, Bojang A, Camara B, Jallow E, Senghore E, Oluwalana C, Bah SY, Turner CE, Sesay AK , D’Alessandro U et al (2020) Impact of intra-partum Azithromycin on carriage of group A streptococcus in The Gambia: a posthoc analysis of a double-blind randomized placebo-controlled trial, Cold Spring Harbor Laboratory.
Stirrup OT, Hughes J, Parker M, Partridge DG, Shepherd JG, Blackstone J, Coll F, Keeley AJ, Lindsey BB, Marek A , Peters C et al (2020) Rapid feedback on hospital onset SARS-CoV-2 infections combining epidemiological and sequencing data, Cold Spring Harbor Laboratory.
Ogbe A, Kronsteiner B, Skelly DT, Pace M, Brown A, Adland E, Adair K, Akhter HD, Ali M, Ali S-E , Angyal A et al (2020) T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses, Cold Spring Harbor Laboratory.
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Lindsey BB, Jagne YJ, Armitage EP, Singanayagam A, Sallah HJ, Drammeh S, Senghore E, Mohammed NI, Jeffries D, Höschler K , Tregoning JS et al (2019) Use of a pandemic H1N1 strain with updated haemagglutinin and neuraminidase results in increased nasopharyngeal shedding and improved immunogenicity to Russian-backbone live attenuated influenza vaccine among children aged 2 – 4 years old: an open-label, prospective, observational, phase 4 study in The Gambia, Cold Spring Harbor Laboratory.
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Asante I, Nienyun Hsu S, Boatemaa L, Kwash L, Aduesi-Poku M, Odom JK, Awuku-Larbi Y, Foulkes BH, Oliver-Commey J, Asiedu E , Parker M et al () Genomic Surveillance of SARS-CoV-2 in Ghana: Leveraging an Integrated National Influenza and SARS-CoV-2 Platform.
Moore S, Kronsteiner B, Longet S, Adele S, Deeks A, Liu C, Dejnirattisai W, Silva Reyes L, Meardon N, Faustini S , Al-Taei S et al () Evolution of Long-Term Hybrid Immunity in Healthcare Workers after Different Covid-19 Vaccination Regimens: A Longitudinal Observational Cohort Study.
Hodgson D, Colton H, Hornsby H, Brown R, Mckenzie J, Bradley KL, James C, Lindsey BB, Birch S, Marsh L , Wood S et al () Risk factors for SARS-CoV-2 seroprevalence following the first pandemic wave in UK healthcare workers in a large NHS Foundation Trust. View this article in WRRO
de Silva TI, Liu G, Lindsey BB, Dong D, Shah D, Mentzer AJ, Angyal A, Brown R, Parker MD, Yin Z , Yao X et al () The Impact of Viral Mutations on Recognition by SARS-CoV-2 Specific T-Cells.
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Tettamanti FAT, Venturini C, Stirrup OT, Guerra-Assuncao JA, Alcolea-Medina A, Becket AH, Byott M, Charalampous T, da Silva Filipe A, Frampton D , Glaysher S et al () The Alpha Variant B.1.1.7 Was Not Associated With Excess Healthcare Acquired COVID-19 Infection in a Multi-Centre UK Hospital Study.
Costa-Martins AG, Mane K, Lindsey BB, Ogava RLT, Castro Í, Jagne YJ, Sallah H, Armitage E, Ahadzie B, Ellis-Watson R , Tregoning JS et al () Pre-Existing Upregulation of Interferon Pathways in the Nasopharynx Impacts Viral Shedding Following Live Attenuated Influenza Vaccine Challenge in Children.
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Roca A () Intense and Mild Wave of COVID-19 in the Gambia: A Cohort Analysis.
Armitage EP, Senghore E, Darboe S, Barry M, Camara J, Bah S, Marks M, Cerami C, Roca A, Antonio M , Turner CE et al () High burden and seasonal variation of paediatric scabies and pyoderma prevalence in The Gambia: a cross-sectional study. View this article in WRRO
Armitage E, de Crombrugghe G, Keeley AJ, Senghore E, Camara FE, Jammeh M, Bittaye A, Ceesay H, Ceesay I, Samateh B , Manneh M et al () Streptococcus Pyogenes Carriage and Infection within Households in the Gambia: A Longitudinal Cohort Study.

Teaching interests: I am involved in delivering the undergraduate (MBChB) Infectious Diseases, Tropical Medicine and Microbiology curriculum at the University of Sheffield. I also lecture on the MSc in Antimicrobial Resistance (MED404), Molecular Medicine MSc (MED6006) and Pharmacology of Respiratory Disease (CDL302, Biomedical Science).

Professional activities and memberships

National and International

Co-chair, Wellcome Trust Early Career Award Interview Committee
Africa Research Excellence Fund (https://www.africaresearchexcellencefund.org.uk/) College of Experts
Vaccines and Infection Subcommittee, British Society of Blood and Marrow Transplantation and cellular therapy (BSBMTCt), vaccination subcommittee

Local

Co-Director, Florey Institute of Infection
Deputy Theme Lead, Infection and Immunity Theme, Sheffield NIHR Biomedical Research Centre
UREC Ethics reviewer for Medical School

Research themes and key projects

Mucosal and systemic immunity to respiratory viruses

ASPIRE: Antisense-mediated state programming for respiratory epithelial defence. (Advanced Research and Invention Agency, 2026 – 2030).
Hybrid immunity to SARS-CoV-2 in Zimbabwean adults with HIV and other chronic diseases (Bill and Melinda Gates Foundation, 2023 – 2026).
Study of SARS-CoV-2 and RSV systemic and mucosal immunity within a household transmission study in The Gambia (UKRI), including PhD supervisor for Dawda Jobe, MRC Gambia, exploring cross-reactive antibody responses to SARS-CoV-2.
Study of SARS-CoV-2 T-cell and antibody responses as part of the PITCH study, OCTAVE study and IMMPROVE consortium (2024 – 2028).
Part of a consortium to establish a Global Paediatric Cell Atlas of Nasal and Oral Mucosa (Chan Zuckerberg Initiative, 2021 – 2026).
Supervisor for Ben Lindsey, Wellcome Trust 4ward North Clinical PhD fellowship on inflammatory memory in the upper respiratory tract following respiratory viral infections (2023 – 2026).

Epidemiology of respiratory viruses

The VIVID Study: Understanding the risk of severe illness from respiratory viruses in vulnerable people (Astra Zeneca, Externally Sponsored Study, 2024 – 2028).
Supervisor for Jack Goodall, Wellcome Trust Clinical PhD fellow (2026 – 2029), investigating how respiratory viruses modulate bacterial colonisation and alter transmission dynamics in the upper respiratory tract.

The epidemiology and immune responses to Streptococcus pyogenes

Co-supervisor for Jenny Hall, MRC Clinical PhD fellow (2026 – 2029), Exploring what drives upsurges in Streptococcus pyogenes disease

Several clinical and molecular epidemiology studies forming part of the MRC Unit The Gambia Strep A research portfolio, including but not limited to:

Lead for immunology studies across UoS and MRC Gambia in a Wellcome Trust funded S. pyogenes human challenge study to establish correlates of protection (2025 – 2027).
Co-lead at the MRC Gambia in a global network of scientists seeking to define correlates of immune protection in natural infection with Streptococcus pyogenes (iSpy Network, 2023 - 2027).

Co-supervisor for Dr Ed Monk, Wellcome Trust Clinical PhD fellow (2024 – 2027), who is using school-based studies to explore transmission and natural immunity to S. pyogenes.