Dr Russell Hughes

School of Medicine and Population Health

Postdoctoral Research Associate

r.o.hughes@sheffield.ac.uk
The Medical School

Full contact details

Dr Russell Hughes
School of Medicine and Population Health
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Profile

Since completing my PhD in the department of Infection & Immunity at the University of Sheffield in 2009, I have held two postdoctoral positions focussing on anti-cancer therapy, based in the Academic Unit of Inflammation & Tumour Targeting.

The first appointment in 2009 was an industrial collaborative project with Astra Zeneca, to develop new screening systems for the identification of novel anti-cancer therapies. In 2011, I was appointed to a CRUK-funded research project to investigate the role of the immune system in the relapse of surgically inoperable cancers.

Most recently, we have been awarded an YCR project grant to develop new strategies to suppress cancer relapse after chemotherapy by targeting tumour infiltrating immune cells.

Research interests

My research interests focus on investigating how the interactions between the various immune cells present within cancers, with an emphasis on the tumour macrophage, influence both a patient's initial response to anti-cancer therapy and how these interactions support the relapse of surgically inoperable cancers following treatment.

My research involves investigating how tumour macrophages help cancers to avoid destruction by the immune system and how tumour macrophages support both the initial growth and relapse of cancers after therapy by regulating their vascular supply.

These studies will aid in the development of new treatments designed to block cancer supporting immune cell and blood vessel interactions. 

This research has received recent media attention:

Current Projects

  • EU Marie Curie ITN Project Grant: Image Guided Surgery and Personalised Postoperative Immunotherapy to Improve Cancer Outcome (2015-2019) Co-I.
  • Yorkshire Cancer Research: Prevention of Tumour Regrowth and Spread after Chemotherapy by Inhibiting Tumour Repair by Macrophages (2015-2018). Co-I.
  • Innovation, Impact and Knowledge Exchange Award: The Role of Perivascular Macrophages in Modulating the Effect of CXCR4 Antagonists on Tumour Regrowth after Chemotherapy (2014-2015) Co-PI.
Publications

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Journal articles

Teaching interests

Tumour microenvironment: Immunology and Angiogenesis