Chloe Thomas
Population Health, School of Medicine and Population Health
Research Fellow
+44 114 222 0785
Full contact details
Population Health, School of Medicine and Population Health
Regent Court (ScHARR)
30 Regent Street
Sheffield
S1 4DA
- Profile
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I joined HEDS in January 2014 as an assistant modeller studying part-time for the HEDM MSc. This was a change of direction following a 13 year career in biomedical research. I completed a BSc in Genetics in 1999 and followed this with a PhD in 2003, both from the University of Sheffield, before working at the University of Nice, France and the department of Biomedical Science at the University of Sheffield.
Within HEDS I specialise in public health-related modelling projects, focussing particularly upon modelling of diabetes and cardiovascular disease prevention, and development of return on investment tools. I have worked closely with Public Health England (PHE), NHS England and NICE for a series of projects modelling the return on investment of the NHS Diabetes Prevention Programme, based upon adaptation of the School for Public Health Research Diabetes Prevention Model. More recently, I worked with PHE to develop a cardiovascular disease prevention return on investment tool. I am also part of the team working on the Sheffield bowel cancer screening model, which informs decisions about the UK bowel cancer screening programme.
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- The costs and benefits of risk-stratification for colorectal cancer screening based on phenotypic and genetic risk: a health economic analysis. Cancer Prevention Research, 14(8), 811-822. View this article in WRRO
- The impact of including costs and outcomes of dementia in a health economic model to evaluate lifestyle interventions to prevent diabetes and cardiovascular disease. Medical Decision Making. View this article in WRRO
- External Validation of a Colorectal Cancer Model Against Screening Trial Long-Term Follow-Up Data. Value in Health, 22(10), 1154-1161. View this article in WRRO
- Assessing the potential return on investment of the proposed UK NHS diabetes prevention programme in different population subgroups: an economic evaluation. BMJ Open, 7. View this article in WRRO
- Cost‐effectiveness of population‐based, community, workplace and individual policies for diabetes prevention in the UK. Diabetic Medicine, 34(8), 1136-1144. View this article in WRRO
- The impact of Type 2 diabetes prevention programmes based on risk‐identification and lifestyle intervention intensity strategies: a cost‐effectiveness analysis. Diabetic Medicine, 34(5), 632-640. View this article in WRRO
- Should colorectal cancer screening start at different ages for men and women? Cost-effectiveness analysis for a resource constrained service. Cancer Reports.
- View this article in WRRO What are the cost-savings and health benefits of improving detection and management for six high cardiovascular risk conditions in England? An economic evaluation. BMJ Open.
All publications
Journal articles
- A systematic review of public health interventions to address breast cancer inequalities in low- and middle-income countries. Systematic Reviews, 13(1). View this article in WRRO
- Understanding the Preferences and Considerations of the Public Towards Risk‐Stratified Screening for Colorectal Cancer: Insights From Think‐Aloud Interviews Based on a Discrete Choice Experiment. Health Expectations, 27(4).
- View this article in WRRO Development of the Microsimulation Model in Cancers of Bladder and Kidney (MiMiC-BlaKy). HEDS Discussion Paper Series(24.03).
- Cross-model validation of public health microsimulation models; comparing two models on estimated effects of a weight management intervention. BMC Public Health, 24. View this article in WRRO
- SA18 Public Health Economic Modelling in Evaluations of Salt and Alcohol Policies: A Scoping Review. Value in Health, 26(12), S544-S544.
- A discrete choice experiment to understand public preferences and priorities for risk-stratified bowel cancer screening programmes in the UK. Preventive Medicine, 107786-107786.
- Dietary Approaches to the Management Of type 2 Diabetes (DIAMOND) in primary care: A protocol for a cluster randomised trial. Contemporary Clinical Trials, 129, 107199-107199.
- Effectiveness and cost-effectiveness of referral to a commercial open group behavioural weight management programme in adults with overweight and obesity: 5-year follow-up of the WRAP randomised controlled trial. The Lancet Public Health, 7(10), e866-e875.
- A community jury study exploring the public acceptability of using risk stratification to determine eligibility for cancer screening. Health Expectations.
- Modelling the impact of the coronavirus pandemic on bowel cancer screening outcomes in England: a decision analysis to prepare for future screening disruption. Preventive Medicine, 160. View this article in WRRO
- A comparison of the World Health Organisation's HEAT model results using a non-linear physical activity dose response function with results from the existing tool. Wellcome Open Research, 7. View this article in WRRO
- An app with brief behavioural support to promote physical activity after a cancer diagnosis (APPROACH) : study protocol for a pilot randomised controlled trial. Pilot and Feasibility Studies, 8(1), 74-74. View this article in WRRO
- Using health economic modelling to inform the design and development of an intervention : estimating the justifiable cost of weight loss maintenance in the UK. BMC Public Health, 22(1). View this article in WRRO
- Development of a Web-Based, Guided Self-help, Acceptance and Commitment Therapy-Based Intervention for Weight Loss Maintenance: Evidence-, Theory-, and Person-Based Approach.. JMIR Form Res, 6(1), e31801.
- A comparison of the World Health Organisation's HEAT model results using a non-linear physical activity dose response function with results from the existing tool. Wellcome Open Research, 7(2022). View this article in WRRO
- The costs and benefits of risk-stratification for colorectal cancer screening based on phenotypic and genetic risk: a health economic analysis. Cancer Prevention Research, 14(8), 811-822. View this article in WRRO
- The price of precision: trade-offs between usability and validity in the World Health Organization Health Economic Assessment Tool for walking and cycling.. Public Health, 194, 263-269.
- Electronic clinical decision support tool for assessing stomach symptoms in primary care (ECASS): a feasibility study. BMJ Open, 11(3).
- Optimizing the Design of a Repeated Fecal Immunochemical Test Bowel Cancer Screening Programme With a Limited Endoscopy Capacity From a Health Economic Perspective. Value in Health.
- The impact of including costs and outcomes of dementia in a health economic model to evaluate lifestyle interventions to prevent diabetes and cardiovascular disease. Medical Decision Making. View this article in WRRO
- External Validation of a Colorectal Cancer Model Against Screening Trial Long-Term Follow-Up Data. Value in Health, 22(10), 1154-1161. View this article in WRRO
- Assessing the potential return on investment of the proposed UK NHS diabetes prevention programme in different population subgroups: an economic evaluation. BMJ Open, 7. View this article in WRRO
- Cost‐effectiveness of population‐based, community, workplace and individual policies for diabetes prevention in the UK. Diabetic Medicine, 34(8), 1136-1144. View this article in WRRO
- Screening for glucose intolerance and development of a lifestyle education programme for prevention of type 2 diabetes in a population with intellectual disabilities: the STOP Diabetes research project. Programme Grants for Applied Research, 5(11). View this article in WRRO
- The impact of Type 2 diabetes prevention programmes based on risk‐identification and lifestyle intervention intensity strategies: a cost‐effectiveness analysis. Diabetic Medicine, 34(5), 632-640. View this article in WRRO
- Estimating the cost-effectiveness of brief interventions for heavy drinking in primary health care across Europe. European Journal of Public Health, 27(2), 345-351. View this article in WRRO
- The cost-effectiveness of an updated theory-based online health behavior intervention for new university students: U@Uni2. Journal of Public Health & Epidemiology, 8(10), 191-203. View this article in WRRO
- Retracted:Impact of Type 2 diabetes prevention programmes based on risk identification and lifestyle intervention intensity strategies: a cost-effectiveness analysis. Diabetic Medicine, 33(8), 1155-1163.
- A theory-based online health behaviour intervention for new university students (U@Uni:LifeGuide): Results from a repeat randomized controlled trial. Trials, 16. View this article in WRRO
- The cost-effectiveness of a theory-based online health behaviour intervention for new university students: an economic evaluation. BMC Public Health, 14(1). View this article in WRRO
- Rabaptin-5 and Rabex-5 are neoplastic tumour suppressor genes that interact to modulate Rab5 dynamics in Drosophila melanogaster.. Dev Biol, 385(1), 107-121. View this article in WRRO
- Planar Polarity Specification through Asymmetric Subcellular Localization of Fat and Dachsous. Current Biology.
- The roles of the cadherins Fat and Dachsous in planar polarity specification in Drosophila. Developmental Dynamics, 192(4).
- JNK signalling influences intracellular trafficking during Drosophila morphogenesis through regulation of the novel target gene Rab30. Developmental Biology, 331(2), 250-260.
- Functional domains and sub-cellular distribution of the Hedgehog transducing protein Smoothened in Drosophila.. Mech Dev, 121(6), 507-518.
- Hedgehog signaling in the Drosophila eye and head: an analysis of the effects of different patched trans-heterozygotes.. Genetics, 165(4), 1915-1928.
- Mutations in the sterol-sensing domain of Patched suggest a role for vesicular trafficking in Smoothened regulation.. Curr Biol, 11(8), 608-613.
- Erratum: Mutations in the sterol sensing domain of patched suggest a role for vesicular trafficking in Smoothened regulation (current biology (2001) 11:8 (608-613)). Current Biology, 11(14), 1153.
- The feasibility and acceptability of an app-based intervention with brief behavioural support (APPROACH) to promote brisk walking in people diagnosed with breast, prostate, and colorectal cancer in the UK. Cancer Medicine.
- Implementation of risk stratification within bowel cancer screening: a community jury study exploring public acceptability and communication needs. BMC Public Health, 23(1).
- The health, cost and equity impacts of restrictions on the advertisement of high fat, salt and sugar products across the Transport for London network: A health economic modelling study. International Journal of Behavioral Nutrition and Physical Activity.
- Estimating the impact of changes in weight and BMI on EQ-5D-3L: a longitudinal analysis of a behavioural group-based weight loss intervention. Quality of Life Research.
- Modelling cost-effective strategies for minimising socioeconomic inequalities in colorectal cancer screening outcomes in England. Preventive Medicine.
- Exploring Structural Uncertainty and Impact of Health State Utility Values on Lifetime Outcomes in Diabetes Economic Simulation Models: Findings from the Ninth Mount Hood Diabetes Quality-of-Life Challenge. Medical Decision Making, 0272989X2110654-0272989X2110654.
- Should colorectal cancer screening start at different ages for men and women? Cost-effectiveness analysis for a resource constrained service. Cancer Reports.
- View this article in WRRO What are the cost-savings and health benefits of improving detection and management for six high cardiovascular risk conditions in England? An economic evaluation. BMJ Open.
- Schizophrenia treatment with second-generation antipsychotics: a multi-country comparison of the costs of cardiovascular and metabolic adverse events and weight gain. Neuropsychiatric Disease and Treatment.
- CALIBRATING NATURAL HISTORY OF CANCER MODELS IN THE PRESENCE OF DATA INCOMPATIBILITY; PROBLEMS AND SOLUTIONS. PharmacoEconomics.
Conference proceedings papers
- PUBLIC HEALTH ECONOMIC MODELLING IN EVALUATIONS OF SALT AND ALCOHOL POLICIES: A SCOPING REVIEW. VALUE IN HEALTH, Vol. 26(12) (pp S544-S544)
- Promoting physical activity via a smartphone application in people living with breast, prostate or colorectal cancer: study protocol for a randomised pilot trial (APPROACH). PSYCHO-ONCOLOGY, Vol. 31 (pp 20-20)
- Validation of the SPHR Diabetes Prevention Model. Value in Health, Vol. 17(7) (pp A556-A556)
- Layering Interventions for Type-2 Diabetes Prevention Using The Sphr Diabetes Model. Value in Health, Vol. 17(7) (pp A347-A347)
Reports
- View this article in WRRO ECASS health economic feasibility study
- View this article in WRRO Optimising Bowel Cancer Screening Phase 1: Optimising the cost effectiveness of repeated FIT screening and screening strategies combining bowel scope and FIT screening
Other
- Supplementary Data from The Costs and Benefits of Risk Stratification for Colorectal Cancer Screening Based On Phenotypic and Genetic Risk: A Health Economic Analysis.
- Supplementary Data from The Costs and Benefits of Risk Stratification for Colorectal Cancer Screening Based On Phenotypic and Genetic Risk: A Health Economic Analysis.
- Data from The Costs and Benefits of Risk Stratification for Colorectal Cancer Screening Based On Phenotypic and Genetic Risk: A Health Economic Analysis.
- Data from The Costs and Benefits of Risk Stratification for Colorectal Cancer Screening Based On Phenotypic and Genetic Risk: A Health Economic Analysis.
Preprints
- View this article in WRRO Calibration and Validation of the Microsimulation Model in Cancer of the Bowel (MiMiC-Bowel), an Individual Patient Simulation Model for Investigation of the Cost-effectiveness of Personalised Screening and Surveillance Strategies..
- Dietary Approaches to the Management of Type 2 Diabetes (DIAMOND) in Primary Care: A Protocol for a Cluster Randomised Trial.
- An App With Brief Behavioural Support to Promote Physical Activity After a Cancer Diagnosis (APPROACH): Study Protocol for a Pilot Randomised Controlled Trial, Research Square Platform LLC.
- Development of a Web-Based, Guided Self-help, Acceptance and Commitment Therapy–Based Intervention for Weight Loss Maintenance: Evidence-, Theory-, and Person-Based Approach (Preprint), JMIR Publications Inc..