Dr Amanda Loban
BSc, PGCert, PhD
Population Health, School of Medicine and Population Health
Head of Data Management
Information Governance Manager
+44 114 222 2995
Full contact details
Population Health, School of Medicine and Population Health
1.09b, 1st Floor
The Innovation Centre
217 Portobello
Sheffield
S1 4DP
- Profile
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Amanda has over 25 years experience managing the data management aspects of MHRA regulated drugs trials. After completing a a degree in Biomedical Science from the University of Central Lancashire and a PhD in Nutritional Biochemistry at the University of Sheffield, she worked for 11 years at PAREXEL International, progressing to Lead Data Manager on a wide variety of clinical trials. These trials were across a variety of phases and indications and included large multi-centre, international drugs trials which involved Europe, the US and Japan. During this time she also completed a post graduate certificate in Clinical Research at the University of Cardiff.
Amanda joined the University of Sheffield Clinical Trials Research Unit in 2009 as a Data Manager, and is Head of Data Management at the unit. She is responsible for the management of the data management group and oversight of data management on CTRU studies. Amanda has also been the Information Governance manager for Sheffield Centre for Health and Related Research since 2016, responsible for the day-to-day operational management of research information governance activities.
Amanda is co-chair on the UKCRC Data and Information Systems Operation Group, and also sits on the ACDM CTU Data Management Expert Group.
- Qualifications
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University of Cardiff, PGCert, Clinical Research (Distinction)
University of Sheffield, Ph.D. Nutritional Biochemistry
University of Central Lancashire, B.Sc. (Hons), Biomedical Sciences (2.1)
- Publications
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Show: Featured publications All publications
Featured publications
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All publications
Journal articles
- “Reality is frequently inaccurate” A case study examining the whens and whys of post-live database changes in a UK clinical trials unit *Douglas Adams. Contemporary Clinical Trials, 142. View this article in WRRO
- Aggressive Multiple Sclerosis: Clinical Phenotype and Treatment Within a Randomised Clinical Trial of Autologous Haematopoietic Stem Cell Transplantation vs High Efficacy Disease Modifying Treatment (P9-6.004). Neurology, 102(17_supplement_1).
- Flexor Injury Rehabilitation Splint Trial (FIRST): protocol for a pragmatic randomised controlled trial comparing three splints for finger flexor tendon repairs. Trials, 25(1). View this article in WRRO
- Safety and efficacy of autologous haematopoietic stem-cell transplantation with low-dose cyclophosphamide mobilisation and reduced intensity conditioning versus standard of care in refractory Crohn’s disease (ASTIClite): an open-label, multicentre, randomised controlled trial. The Lancet Gastroenterology and Hepatology. View this article in WRRO
- Personalised versus standard text message prompts for increasing trial participant response to telephone follow-up: an embedded randomised controlled retention trial. Trials, 25(1). View this article in WRRO
- The MAGIC trial: a pragmatic, multicentre, parallel, noninferiority, randomised trial of melatonin versus midazolam in the premedication of anxious children attending for elective surgery under general anaesthesia. British Journal of Anaesthesia. View this article in WRRO
- Comparison of amitriptyline supplemented with pregabalin, pregabalin supplemented with amitriptyline, and duloxetine supplemented with pregabalin for the treatment of diabetic peripheral neuropathic pain (OPTION-DM): a multicentre, double-blind, randomised crossover trial. The Lancet, 400(10353), 680-690. View this article in WRRO
- An intervention to promote self-management, independence and self-efficacy in people with early-stage dementia: the Journeying through Dementia RCT.. Health Technol Assess, 26(24), 1-152.
- The Journeying through Dementia psychosocial intervention versus usual care study: a single-blind, parallel group, phase 3 trial. The Lancet Healthy Longevity, 3(4), e276-e285.
- Post-exertion oxygen saturation as a prognostic factor for adverse outcome in patients attending the emergency department with suspected COVID-19: a substudy of the PRIEST observational cohort study. Emergency Medicine Journal. View this article in WRRO
- Characterisation of 22445 patients attending UK emergency departments with suspected COVID-19 infection : observational cohort study. PLoS ONE, 15(11). View this article in WRRO
- Study protocol for a randomised controlled trial assessing the clinical and cost-effectiveness of the Journeying through Dementia (JtD) intervention compared to usual care. BMJ Open, 9(9). View this article in WRRO
- Multicentre, double-blind, crossover trial to identify the Optimal Pathway for TreatIng neurOpathic paiN in Diabetes Mellitus (OPTION-DM): study protocol for a randomised controlled trial. Trials, 19(1), 578-578. View this article in WRRO
- The association between long-term conditions and uptake of population-based screening for colorectal cancer: results from two English cohort studies. Cancer Management and Research, 10, 637-645. View this article in WRRO
- A randomized trial found online questionnaires supplemented by postal reminders generated a cost-effective and generalizable sample but don’t forget the reminders. Journal of Clinical Epidemiology, 92, 116-125. View this article in WRRO
- PLEASANT: Preventing and Lessening Exacerbations of Asthma in School-age children Associated with a New Term - a cluster randomised controlled trial and economic evaluation.. Health Technology Assessment, 20(93), 1-154. View this article in WRRO
- Cohort Profile: The Yorkshire Health Study.. Int J Epidemiol, 45(3), 707-712. View this article in WRRO
- ‘Fish out of water’: a cross-sectional study on the interaction between social and neighbourhood effects on weight management behaviours. International Journal of Obesity, 39(3), 535-541. View this article in WRRO
- "Booster" interventions to sustain increases in physical activity in middle-aged adults in deprived urban neighbourhoods: internal pilot and feasibility study. BMC Public Health, 11(1). View this article in WRRO
- South Yorkshire Cohort: a 'cohort trials facility' study of health and weight - protocol for the recruitment phase.. BMC Public Health, 11, 640. View this article in WRRO
- Iron-Binding Antioxidant Potential of Plasma Albumin. Clinical Science, 93(5), 445-451.
- Vitamin C at Concentrations Observed in Premature Babies Inhibits the Ferroxidase Activity of Caeruloplasmin. Free Radical Research, 22(1), 57-65.
- Autologous stem cell transplantation with low-dose cyclophosphamide to improve mucosal healing in adults with refractory Crohn’s disease: the ASTIClite RCT. Efficacy and Mechanism Evaluation, 1-106.
- Optimal pharmacotherapy pathway in adults with diabetic peripheral neuropathic pain: the OPTION-DM RCT. Health Technology Assessment, 26(39), 1-100.
- Enhancing Social-Emotional Outcomes in Early Years (E-SEE): Randomized Pilot Study of Incredible Years Infant and Toddler Programs. Journal of Child and Family Studies.
- Prognostic accuracy of emergency department triage tools for adults with suspected COVID-19: the PRIEST observational cohort study. Emergency Medicine Journal.
- Derivation and validation of a clinical severity score for acutely ill adults with suspected COVID-19: The PRIEST observational cohort study. PLOS ONE, 16(1), e0245840-e0245840.
- Characterisation of 22446 patients attending UK emergency departments with suspected COVID-19 infection: Observational cohort study. View this article in WRRO
Conference proceedings papers
- LATE-BREAKING ABSTRACT: PLEASANT: Preventing and lessening exacerbations of asthma in school-age children associated with a new term. 1.6 General Practice and Primary Care
Datasets
Preprints
- Flexor Injury Rehabilitation Splint Trial (FIRST): Protocol for a pragmatic randomised controlled trial comparing three splints for finger flexor tendon repairs, Research Square Platform LLC.
- Derivation and validation of a clinical severity score for acutely ill adults with suspected COVID-19: The PRIEST observational cohort study, Cold Spring Harbor Laboratory.
- Prognostic accuracy of emergency department triage tools for adults with suspected COVID-19: The PRIEST observational cohort study, Cold Spring Harbor Laboratory.
- Prognostic accuracy of emergency department triage tools for children with suspected COVID-19: The PRIEST observational cohort study, Cold Spring Harbor Laboratory.
- Professional activities and memberships
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Member of the Association for Clinical Data Management (ACDM) CTU Data Management Expert Group
Joint Chair of the Data and Information Systems Operational Group (DISOG) at UKCRC Registered CTU Network