Nucleic acids in health and disease
Our research teams focus on all aspects of nucleic acids in health and disease, with the goal of better understanding basic processes and developing therapeutic interventions to improve human health.
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The health of our cells depends on the smooth running of processes controlled by nucleic acids. Diseases can arise when these processes go awry. For instance, cancer may develop when mutations accumulate in DNA, or when the complex mechanisms which maintain genome integrity break down, leading to malfunctioning proteins. Alternatively, genes might be switched on or off at inappropriate times or locations, and changes in RNA structure have been linked to neurodegenerative diseases like ALS.
This research theme is led by Dr Tatyana Shelkovnikova.
Related members
- Professor Ivana Barbaric
- Professor Helen Bryant
- Professor James Catto
- Dr Spencer Collis
- Dr Johnathan Cooper-Knock
- Professor Sherif El-Khamisy
- Dr Luke Green
- Professor Guillaume Hautbergue
- Dr Adam Hodgson
- Dr Daniel Humphreys
- Dr Stuart Hunt
- Professor Keith Hunter
- Professor Daniel Lambert
- Dr Cyril Sanders
- Dr Tatyana Shelkovnikova
- Professor Jim Thomas
- Dr Ruth Thompson
- Dr Anestis Tsakiridis
- Dr Freek van Eeden