Professor Mark Wilkinson
MB, ChB, PhD, FRCS
School of Medicine and Population Health
Professor of Orthopaedics
j.m.wilkinson@sheffield.ac.uk
+44 114 215 9029
+44 114 215 9029
+44 114 261 8775
(Fax)
EU14, E Floor, The Medical School
Full contact details
Professor Mark Wilkinson
School of Medicine and Population Health
EU14, E Floor
The Medical School
Beech Hill Road
Sheffield
S10 2RX
School of Medicine and Population Health
EU14, E Floor
The Medical School
Beech Hill Road
Sheffield
S10 2RX
- Profile
-
For enquiries, please contact - SMPH-West-Operational@sheffield.ac.uk
Career history
- 1991 MBChB University of Sheffield
- 1991-1996 Basic Surgical Training, Royal Hallamshire Hospital, Sheffield
- 1996 FRCS Royal College of Surgeons (Eng)
- 1996-2006 Higher Surgical Training North Trent HST Program
- 2002 PhD University of Sheffield
- 2004 FRCS (Ortho) Royal College of Surgeons (Eng)
- 2006 Consultant Orthopaedic Surgeon, Stockport
- 2007 HEFCE Clinical Senior Lecturer, University of Sheffield
- 2007 Honorary Consultant in Orthopaedics, Sheffield Teaching Hospitals
- 2012 Professor of Orthopaedics, University of Sheffield
- Research interests
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- Joint arthroplasty mechanisms of failure
- Cytokine genetics
- Metabolic bone disease
- Novel biological therapies for osteolysis
- Surrogate outcome markers for implant performance and failure
- Clinical outcomes measurement after THA
- Genetics of bone shape and remodelling responses to disease
- Genetics of osteoarthritis
- Effects of metal ion exposure on bone and other organ systems
- Publications
-
Show: Featured publications All publications
Featured publications
Journal articles
- The risk of all-cause mortality, heart outcomes, cancer, and neurodegenerative disorders with cobalt-chrome-containing total hip arthroplasty implants : an analysis of the National Joint Registry.. The Bone & Joint Journal, 1-9.
- Accelerating functional gene discovery in osteoarthritis. Nature Communications, 12(1).
- Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations. Cell, 184(24), 6003-6005.
- Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations. Cell.
- Collection and reporting of patient-reported outcome measures in arthroplasty registries : multinational survey and recommendations. Clinical Orthopaedics and Related Research.
- Obesity and revision surgery, mortality, and patient-reported outcomes after primary knee replacement surgery in the National Joint Registry : a UK cohort study. PLoS Medicine, 18(7).
- Effect of tourniquet use on the risk of revision in total knee replacement surgery : an analysis of the National Joint Registry Data Set. BMJ Open, 11(6). View this article in WRRO
- Distinct concentration-dependent molecular pathways regulate bone cell responses to cobalt and chromium exposure from joint replacement prostheses. International Journal of Molecular Sciences, 22(10). View this article in WRRO
- Patellar resurfacing during primary total knee replacement is associated with a lower risk of revision surgery.. The Bone & Joint Journal, 103-B(5), 864-871. View this article in WRRO
- Linking chondrocyte and synovial transcriptional profile to clinical phenotype in osteoarthritis. Annals of the Rheumatic Diseases.
- A molecular quantitative trait locus map for osteoarthritis. Nature Communications, 12.
- Effect of denosumab on osteolytic lesion activity after total hip arthroplasty: a single-centre, randomised, double-blind, placebo-controlled, proof of concept trial. The Lancet Rheumatology. View this article in WRRO
- Personalized estimation of one-year mortality risk after elective hip or knee arthroplasty for osteoarthritis. Bone & Joint Research, 9(11), 808-820. View this article in WRRO
- Influence of femoral component design on proximal femoral bone mass after total hip replacement : a randomized controlled trial. Journal of Bone and Joint Surgery. View this article in WRRO
- Genome-wide association of phenotypes based on clustering patterns of hand osteoarthritis identify WNT9A as novel osteoarthritis gene. Annals of the Rheumatic Diseases. View this article in WRRO
- JointCalc: A web-based personalised patient decision support tool for joint replacement. International Journal of Medical Informatics, 142. View this article in WRRO
- Use of public datasets in the examination of multimorbidity: opportunities and challenges. Mechanisms of Ageing and Development, 190. View this article in WRRO
- The use of bisphosphonates to meet orthopaedic challenges. Bone. View this article in WRRO
- The Uptake of New Knee Replacement Implants in the UK: Analysis of the National Joint Registry for England and Wales. The Journal of Arthroplasty, 35(3), 699-705.e3.
- Understanding the uptake of new hip replacement implants in the UK : a cohort study using data from the national joint registry for England and Wales. BMJ Open, 9(11). View this article in WRRO
- A spatio-temporal ageing atlas of the proximal femur. IEEE Transactions on Medical Imaging. View this article in WRRO
- Homogeneity in prediction of survival probabilities for subcategories of hipprosthesis data : the Nordic Arthroplasty Register Association, 2000–2013. Clinical Epidemiology, 2019(11), 519-524. View this article in WRRO
- Effect of Alendronic Acid on Fracture Healing: A Multicenter Randomized Placebo‐Controlled Trial. Journal of Bone and Mineral Research, 34(6), 1025-1032. View this article in WRRO
- Orthopaedic registries with patient-reported outcome measures. EFORT Open Reviews, 4(6), 357-367. View this article in WRRO
- The 2018 Otto Aufranc Award: How Does Genome-wide Variation Affect Osteolysis Risk After THA?. Clinical Orthopaedics and Related Research, 477(2), 297-309. View this article in WRRO
- Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data. Nature Genetics, 51, 230-236. View this article in WRRO
- Temporal trends and survivorship of total hip arthroplasty in very young patients. The Bone & Joint Journal, 100-B(10), 1320-1329. View this article in WRRO
- Estimating an Individual's Probability of Revision Surgery After Knee Replacement: A Comparison of Modeling Approaches Using a National Dataset. American Journal of Epidemiology, 187(10), 2252-2262. View this article in WRRO
- Genome-wide association study of developmental dysplasia of the hip identifies an association with GDF5. Communications Biology, 1. View this article in WRRO
- Widespread epigenomic, transcriptomic and proteomic differences between hip osteophytic and articular chondrocytes in osteoarthritis.. Rheumatology. View this article in WRRO
- Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis. Nature Genetics, 50(4), 549-558. View this article in WRRO
- A novel variant in GLIS3 is associated with osteoarthritis. Annals of the Rheumatic Diseases, 77(4), 620-623. View this article in WRRO
- The risk of cardiac failure following metal-on-metal hip arthroplasty. The Bone & Joint Journal, 100-B(1), 20-27. View this article in WRRO
- An analysis of 30-day mortality after weekend versus weekday elective joint arthroplasty in England and Wales: A cohort study using the national joint registry dataset. Bone and Joint Journal, 99B(12), 1618-1628. View this article in WRRO
- Integrative epigenomics, transcriptomics and proteomics of patient chondrocytes reveal genes and pathways involved in osteoarthritis. Scientific Reports, 7(1). View this article in WRRO
- Quantitating the effect of prosthesis design on femoral remodeling using high-resolution region-free densitometric analysis (DXA-RFA). Journal of Orthopaedic Research, 35(10), 2203-2210. View this article in WRRO
- Effects of chronic cobalt and chromium exposure after metal-on-metal hip resurfacing: An epigenome-wide association pilot study. Journal of Orthopaedic Research, 35(10), 2323-2328. View this article in WRRO
- Evaluation of shared genetic aetiology between osteoarthritis and bone mineral density identifies SMAD3 as a novel osteoarthritis risk locus. Human Molecular Genetics, 26(19), 3850-3858. View this article in WRRO
- Pathways to understanding the genomic aetiology of osteoarthritis. Human Molecular Genetics. View this article in WRRO
- Quantifying Pelvic Periprosthetic Bone Remodeling Using Dual-Energy X-Ray Absorptiometry Region-Free Analysis. Journal of Clinical Densitometry. View this article in WRRO
- Radiographic endophenotyping in hip osteoarthritis improves the precision of genetic association analysis. Annals of the Rheumatic Diseases, 76, 1199-1206. View this article in WRRO
- Rates of hip and knee joint replacement amongst different ethnic groups in England: an analysis of National Joint Registry data. Osteoarthritis and Cartilage. View this article in WRRO
- Good outcome of total hip replacement in patients with cerebral palsy. Acta Orthopaedica, 87(2), 93-99. View this article in WRRO
- Particle-Induced Osteolysis Is Mediated by TIRAP/Mal in Vitro and in Vivo. The Journal of Bone and Joint Surgery, 98(4), 285-294.
- The Genetic Epidemiological Landscape of Hip and Knee Osteoarthritis: Where Are We Now and Where Are We Going?. The Journal of Rheumatology, 43(2), 260-266.
- Histone deacetylase 1 regulates tissue destruction in rheumatoid arthritis. Human Molecular Genetics, 24(19), 5367-5377. View this article in WRRO
- Human breast cancer bone metastasis in vitro and in vivo: a novel 3D model system for studies of tumour cell-bone cell interactions. Clinical & Experimental Metastasis, 32(7), 689-702. View this article in WRRO
- Investigation of Association Between Hip Osteoarthritis Susceptibility Loci and Radiographic Proximal Femur Shape. Arthritis & Rheumatology, 67(8), 2076-2084. View this article in WRRO
- Cobalt and chromium exposure affects osteoblast function and impairs the mineralization of prosthesis surfaces in vitro. Journal of Orthopaedic Research, 33(11), 1663-1670. View this article in WRRO
- Genetic variation in inflammatory and bone turnover pathways and risk of osteolytic responses to prosthetic materials. Journal of Orthopaedic Research, 33(2), 193-198. View this article in WRRO
- High-Spatial-Resolution Bone Densitometry with Dual-Energy X-ray Absorptiometric Region-free Analysis. Radiology, 274(2), 532-539. View this article in WRRO
- Use of high resolution dual-energy x-ray absorptiometry-region free analysis (DXA-RFA) to detect local periprosthetic bone remodeling events. Journal of Orthopaedic Research, 33(5), 712-716. View this article in WRRO
- Understanding the tissue effects of tribo-corrosion: Uptake, distribution, and speciation of cobalt and chromium in human bone cells. Journal of Orthopaedic Research, 33(1), 114-121.
- Patient safety after partial and total knee replacement. The Lancet, 384(9960), 2106-2106.
- Systemic toxicity related to metal hip prostheses. Clinical Toxicology, 52(8), 837-847.
- Brain structure and function in patients after metal-on-metal hip resurfacing.. AJNR Am J Neuroradiol, 35(9), 1753-1758.
- Statistical shape and appearance models in osteoporosis.. Curr Osteoporos Rep, 12(2), 163-173.
- Assessment of osteoarthritis candidate genes in a meta-analysis of nine genome-wide association studies. Arthritis and Rheumatology, 66(4), 940-949. View this article in WRRO
- Cannabinoid WIN-55,212-2 mesylate inhibits interleukin-1β induced matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase expression in human chondrocytes.. Osteoarthritis Cartilage, 22(1), 133-144.
- Auditory and visual health after ten years of exposure to metal-on-metal hip prostheses: a cross-sectional study follow up.. PLoS One, 9(3), e90838. View this article in WRRO
- A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip. Annals of the Rheumatic Diseases, 73(12), 2130-2136. View this article in WRRO
- A TNF Variant that Associates with Susceptibility to Musculoskeletal Disease Modulates Thyroid Hormone Receptor Binding to Control Promoter Activation. PLoS ONE, 8(9). View this article in WRRO
- Development of a fully automatic shape model matching (FASMM) system to derive statistical shape models from radiographs: application to the accurate capture and global representation of proximal femur shape.. Osteoarthritis Cartilage, 21(10), 1537-1544.
- Quantifying the characteristics of the acetabulum and proximal femur using a semi-automated hip morphology software programme (SHIPS).. Hip Int, 23(3), 330-336.
- Fully automatic segmentation of the proximal femur using random forest regression voting.. IEEE Trans Med Imaging, 32(8), 1462-1472.
- Effect of sliding-taper compared with composite-beam cemented femoral prosthesis loading regime on proximal femoral bone remodeling: a randomized clinical trial.. J Bone Joint Surg Am, 95(1), 19-27.
- Pelvic Periprosthetic Bone Mineral Density Measurement Around Cemented vs Cementless Acetabular Prostheses. Journal of Clinical Densitometry.
- Use of kernel-based Bayesian models to predict late osteolysis after hip replacement.. J R Soc Interface, 10(88), 20130678. View this article in WRRO
- Investigation of polarization-sensitive optical coherence tomography towards the study of microstructure of articular cartilage. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 8571.
- Metal-on-metal hip prostheses and systemic health: a cross-sectional association study 8 years after implantation.. PLoS One, 8(6), e66186. View this article in WRRO
- No evidence of an association between mitochondrial DNA variants and osteoarthritis in 7393 cases and 5122 controls. Annals of the Rheumatic Diseases, 72(1), 136-139. View this article in WRRO
- Evaluation of the genetic overlap between osteoarthritis with body mass index and height using genome-wide association scan data.. Ann Rheum Dis, 72(6), 935-941. View this article in WRRO
- Cannabinoids: novel therapies for arthritis?. Future Med Chem, 4(6), 713-725.
- Metal-on-metal hip prostheses: where are we now?. BMJ, 345, e7792.
- Identification of new susceptibility loci for osteoarthritis (arcOGEN): A genome-wide association study. The Lancet, 380(9844), 815-823.
- Use of the Sheffield Telescopic Intramedullary Rod System for the Management of Osteogenesis Imperfecta Clinical Outcomes at an Average Follow-up of Nineteen Years. JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 93A(21), 1994-2000.
- A Variant in MCF2L Is Associated with Osteoarthritis. AM J HUM GENET, 89(3), 446-450.
- Effects of cobalt and chromium ions at clinically equivalent concentrations after metal-on-metal hip replacement on human osteoblasts and osteoclasts: implications for skeletal health.. Bone, 49(4), 717-723. View this article in WRRO
- Bisphosphonates in orthopedic applications.. Bone, 49(1), 95-102.
- Insights into the genetic architecture of osteoarthritis from stage 1 of the arcOGEN study. Annals of the Rheumatic Diseases, 70(5), 864-867. View this article in WRRO
- The effect of genome-wide association scan quality control on imputation outcome for common variants. European Journal of Human Genetics, 19(5), 610-614. View this article in WRRO
- Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22. Annals of the Rheumatic Diseases, 70(2), 349-355.
- Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: The TREAT-OA consortium. Osteoarthritis and Cartilage, 19(3), 254-264.
- Long-term outcome of a cementless, hemispherical, press-fit acetabular component SURVIVORSHIP ANALYSIS AND DOSE-RESPONSE RELATIONSHIP TO LINEAR POLYETHYLENE WEAR. J BONE JOINT SURG BR, 92B(6), 856-861.
- Individual susceptibility to periprosthetic osteolysis is associated with altered patterns of innate immune gene expression in response to pro-inflammatory stimuli.. J Orthop Res, 28(9), 1127-1135.
- What potential biologic treatments are available for osteolysis?. Journal of the American Academy of Orthopaedic Surgeons, 16, S72-S75.
- Polymorphisms in the interleukin-1 receptor antagonist and interleukin-6 genes affect risk of osteolysis in patients with total hip arthroplasty.. Arthritis Rheum, 58(10), 3157-3165.
- Variation in the secreted frizzled-related protein-3 gene and risk of osteolysis and heterotopic ossification after total hip arthroplasty.. J Orthop Res, 25(12), 1665-1670.
- Hip and knee reconstruction in the rheumatoid patient. CURR ORTHOPAED, 21(5), 330-339.
- Clinical and radiological outcome of total hip replacement five years after pamidronate therapy. A trial extension.. J Bone Joint Surg Br, 88(10), 1309-1315.
- Bone remodelling around a cemented polyethylene cup. A longitudinal densitometry study.. J Bone Joint Surg Br, 88(4), 455-459.
- Accuracy of joint aspiration for the preoperative diagnosis of infection in total hip arthroplasty.. J Arthroplasty, 21(2), 221-226.
- Polyethylene wear rate and osteolysis: critical threshold versus continuous dose-response relationship.. J Orthop Res, 23(3), 520-525.
- Effect of pamidronate on bone turnover and implant migration after total hip arthroplasty: a randomized trial.. J Orthop Res, 23(1), 1-8.
- Surgical management of the rheumatoid patient. CURR ORTHOPAED, 18(5), 357-370.
- Variation in the TNF gene promoter and risk of osteolysis after total hip arthroplasty.. J Bone Miner Res, 18(11), 1995-2001.
- Effect of pamidronate on excretion of pyridinium crosslinks of collagen after total hip arthroplasty.. Calcif Tissue Int, 73(4), 326-331.
- Bone mineral density and biochemical markers of bone turnover in aseptic loosening after total hip arthroplasty.. J Orthop Res, 21(4), 691-696.
- Biochemical markers of bone turnover and development of heterotopic ossification after total hip arthroplasty.. J Orthop Res, 21(3), 529-534.
- Direct plain radiographic methods versus EBRA-Digital for measuring implant migration after total hip arthroplasty.. J Arthroplasty, 17(7), 917-925.
- Precision of EBRA-Digital software for monitoring implant migration after total hip arthroplasty.. J Arthroplasty, 17(7), 910-916.
- Posterior surgical approaches to the elbow: a comparative anatomic study.. J Shoulder Elbow Surg, 10(4), 380-382.
- Effect of pamidronate in preventing local bone loss after total hip arthroplasty: a randomized, double-blind, controlled trial.. J Bone Miner Res, 16(3), 556-564.
- Measuring bone mineral density of the pelvis and proximal femur after total hip arthroplasty.. J Bone Joint Surg Br, 83(2), 283-288.
- Effect of mixing technique on the properties of acrylic bone-cement: a comparison of syringe and bowl mixing systems.. J Arthroplasty, 15(5), 663-667.
- Surgical stabilisation of the lower limb in osteogenesis imperfecta using the Sheffield Telescopic Intramedullary Rod System.. J Bone Joint Surg Br, 80(6), 999-1004.
- Assessment of osteoporosis at autopsy: mechanical methods compared to radiological and histological techniques.. Med Sci Law, 31(1), 19-24.
Conference proceedings papers
- Spatio-Temporal Atlas of Bone Mineral Density Ageing (pp 720-728)
- Identification of five novel osteoarthritis susceptibility loci through the UK biobank resourse of five novel osteoarthritis susceptibility loci through the UK biobank resourse. Osteoarthritis and Cartilage, Vol. 25 (pp S38-S39)
- Improved phenotype definitions of OA in genetic association studies highlight a structural role for a common variant in LRCH1. Osteoarthritis and Cartilage, Vol. 23 (pp A70-A70)
- Investigation Of The Role Of Histone Deacetylases In Rheumatoid Arthritis Synovial Fibroblasts. ARTHRITIS AND RHEUMATISM, Vol. 65 (pp S1035-S1036)
- What are the local and systemic biologic reactions and mediators to wear debris, and what host factors determine or modulate the biologic response to wear particles?. JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS, Vol. 16 (pp S42-S48)
All publications
Journal articles
- Primary cartilage transcriptional signatures reflect cell-type-specific molecular pathways underpinning osteoarthritis. The American Journal of Human Genetics.
- Epigenomic differences between osteoarthritis grades in primary cartilage. Osteoarthritis and Cartilage.
- PERI-operative biologic DMARD management: Stoppage or COntinuation during orthoPaEdic operations (the PERISCOPE trial) – a study protocol for a pragmatic, UK multicentre, superiority randomised controlled trial with an internal pilot, economic evaluation and nested qualitative study. BMJ Open, 14(6), e084997-e084997.
- OA30 Primary osteoarthritis chondrocyte map of chromatin conformation reveals novel effector genes. Rheumatology, 63(Supplement_1).
- PROFILING METHYLATION IN PRIMARY OSTEOARTHRITIS CARTILAGE. Osteoarthritis and Cartilage, 32, S484-S484.
- The molecular environment of osteoarthritis risk genes in primary cartilage. Osteoarthritis and Cartilage, 32, S475-S476.
- PRIMARY OSTEOARTHRITIS CHONDROCYTE MAP OF CHROMATIN CONFORMATION REVEALS NOVEL PUTATIVE EFFECTOR GENES. Osteoarthritis and Cartilage, 32, S467-S468.
- Primary osteoarthritis chondrocyte map of chromatin conformation reveals novel candidate effector genes. Annals of the Rheumatic Diseases. View this article in WRRO
- Cementing Techniques In Knee Surgery (CeTIKS): a UK expert consensus study.. Bone Jt Open, 4(9), 682-688.
- USING CLASSIFIER NEURAL NETWORKS TO ESTIMATE PERSONALIZED PATIENT-REPORTED OUTCOME MEASURES AFTER HIP ARTHROPLASTY. Orthopaedic Proceedings, 105-B(SUPP_12), 85-85.
- Osteoarthritis genetic risk acting on the galactosyltransferase gene COLGALT2 has opposing functional effects in articulating joint tissues. Arthritis Research & Therapy, 25(1).
- Identification of implant outliers in joint replacement registries. EFORT Open Reviews, 8(1), 11-17.
- The genetic and epigenetic contributions to the development of nutritional rickets. Frontiers in Endocrinology, 13.
- Independent osteoarthritis risk-conferring alleles mediate the same epigenetic and transcriptional effect on a shared target gene, COLGALT2. Arthritis & Rheumatology.
- International assessment of the use and results of patient-reported outcome measures for hip and knee replacement surgery.
- The mechano-ubiquitinome of articular cartilage: Differential ubiquitination and activation of a group of ER-associated DUBs and ER stress regulators. Molecular & Cellular Proteomics, 100419-100419.
- Implementing large-scale data quality validation in a national arthroplasty registry to improve compliance. Bone & Joint Open, 3(9), 716-725.
- Temporal trends in comorbidity in adult elective hip and knee arthroplasty patients in England. The Bone & Joint Journal, 104-B(9), 1052-1059.
- Quantitating Age-Related BMD Textural Variation from DXA Region-Free-Analysis: A Study of Hip Fracture Prediction in Three Cohorts. Journal of Bone and Mineral Research.
- How do Patient-reported Outcome Scores in International Hip and Knee Arthroplasty Registries Compare?. Clinical Orthopaedics & Related Research, Publish Ahead of Print.
- What effect have NHS commissioners’ policies for body mass index had on access to knee replacement surgery in England?: An interrupted time series analysis from the National Joint Registry. PLoS ONE, 17(6).
- Pathophysiology and emerging molecular therapeutic targets in heterotopic ossification. International Journal of Molecular Sciences, 23(13).
- An epigenome-wide view of osteoarthritis in primary tissues. The American Journal of Human Genetics.
- The risk of all-cause mortality, heart outcomes, cancer, and neurodegenerative disorders with cobalt-chrome-containing total hip arthroplasty implants. The Bone & Joint Journal, 104-B(3), 359-367.
- Rare SLC13A1 variants associate with intervertebral disc disorder highlighting role of sulfate in disc pathology. Nature Communications, 13(1). View this article in WRRO
- The risk of all-cause mortality, heart outcomes, cancer, and neurodegenerative disorders with cobalt-chrome-containing total hip arthroplasty implants : an analysis of the National Joint Registry.. The Bone & Joint Journal, 1-9.
- Using multivariable Mendelian randomization to estimate the causal effect of bone mineral density on osteoarthritis risk, independently of body mass index. International Journal of Epidemiology, 51(4), 1254-1267.
- Accelerating functional gene discovery in osteoarthritis. Nature Communications, 12(1).
- Unicompartmental compared with total knee replacement for patients with multimorbidities : a cohort study using propensity score stratification and inverse probability weighting. Health Technology Assessment, 25(66), 1-125.
- Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations. Cell, 184(24), 6003-6005.
- Metaparametric neural networks for survival analysis. IEEE Transactions on Neural Networks and Learning Systems.
- Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations. Cell.
- A comparison of comorbidity measures for predicting mortality after elective hip and knee replacement : a cohort study of data from the National Joint Registry in England and Wales. PLoS ONE, 16(8).
- Collection and reporting of patient-reported outcome measures in arthroplasty registries : multinational survey and recommendations. Clinical Orthopaedics and Related Research.
- Obesity and revision surgery, mortality, and patient-reported outcomes after primary knee replacement surgery in the National Joint Registry : a UK cohort study. PLoS Medicine, 18(7).
- Effect of tourniquet use on the risk of revision in total knee replacement surgery : an analysis of the National Joint Registry Data Set. BMJ Open, 11(6). View this article in WRRO
- Denosumab after total hip arthroplasty – Authors' reply. The Lancet Rheumatology, 3(6), e406-e407. View this article in WRRO
- Publisher Correction: Accelerating functional gene discovery in osteoarthritis.. Nat Commun, 12(1), 3302.
- Distinct concentration-dependent molecular pathways regulate bone cell responses to cobalt and chromium exposure from joint replacement prostheses. International Journal of Molecular Sciences, 22(10). View this article in WRRO
- Patellar resurfacing during primary total knee replacement is associated with a lower risk of revision surgery.. The Bone & Joint Journal, 103-B(5), 864-871. View this article in WRRO
- Linking chondrocyte and synovial transcriptional profile to clinical phenotype in osteoarthritis. Annals of the Rheumatic Diseases.
- International variation in distribution of ASA class in patients undergoing total hip arthroplasty and its influence on mortality: data from an international consortium of arthroplasty registries. Acta Orthopaedica.
- A molecular quantitative trait locus map for osteoarthritis. Nature Communications, 12.
- Revision and 90-day mortality following hip arthroplasty in patients with inflammatory arthritis and ankylosing spondylitis enrolled in the National Joint Registry for England and Wales. HIP International.
- Effect of denosumab on osteolytic lesion activity after total hip arthroplasty: a single-centre, randomised, double-blind, placebo-controlled, proof of concept trial. The Lancet Rheumatology. View this article in WRRO
- Transmission of whole body vibration – comparison of three vibration platforms in healthy subjects. Bone, 144. View this article in WRRO
- A new approach to comprehensively evaluate the morphological properties of the human femoral head : example of application to osteoarthritic joint. Scientific Reports, 10(1). View this article in WRRO
- Personalized estimation of one-year mortality risk after elective hip or knee arthroplasty for osteoarthritis. Bone & Joint Research, 9(11), 808-820. View this article in WRRO
- Influence of femoral component design on proximal femoral bone mass after total hip replacement : a randomized controlled trial. Journal of Bone and Joint Surgery. View this article in WRRO
- Heterogeneous strain distribution in the subchondral bone of human osteoarthritic femoral heads, measured with digital volume correlation. Materials, 13(20). View this article in WRRO
- Genome-wide association of phenotypes based on clustering patterns of hand osteoarthritis identify WNT9A as novel osteoarthritis gene. Annals of the Rheumatic Diseases. View this article in WRRO
- JointCalc: A web-based personalised patient decision support tool for joint replacement. International Journal of Medical Informatics, 142. View this article in WRRO
- Use of public datasets in the examination of multimorbidity: opportunities and challenges. Mechanisms of Ageing and Development, 190. View this article in WRRO
- The use of bisphosphonates to meet orthopaedic challenges. Bone. View this article in WRRO
- Epigenome-wide association study in knee osteoarthritis generates novel insights into disease mechanisms. Osteoarthritis and Cartilage, 28, S53-S53.
- Response to: Effects of Alendronic Acid on Fracture Healing. Journal of Bone and Mineral Research, 35(1), 215-216.
- The Uptake of New Knee Replacement Implants in the UK: Analysis of the National Joint Registry for England and Wales. The Journal of Arthroplasty, 35(3), 699-705.e3.
- Development of clinically relevant in vivo metastasis models using human bone discs and breast cancer patient-derived xenografts. Breast Cancer Research, 21(1). View this article in WRRO
- Understanding the uptake of new hip replacement implants in the UK : a cohort study using data from the national joint registry for England and Wales. BMJ Open, 9(11). View this article in WRRO
- A spatio-temporal ageing atlas of the proximal femur. IEEE Transactions on Medical Imaging. View this article in WRRO
- Homogeneity in prediction of survival probabilities for subcategories of hipprosthesis data : the Nordic Arthroplasty Register Association, 2000–2013. Clinical Epidemiology, 2019(11), 519-524. View this article in WRRO
- Effect of Alendronic Acid on Fracture Healing: A Multicenter Randomized Placebo‐Controlled Trial. Journal of Bone and Mineral Research, 34(6), 1025-1032. View this article in WRRO
- The hip arthroplasty journey : where are we going and who is paying the bill?. Bone and Joint Research, 8(6), 224-225. View this article in WRRO
- Orthopaedic registries with patient-reported outcome measures. EFORT Open Reviews, 4(6), 357-367. View this article in WRRO
- Orthopaedic registries - the UK view (National Joint Registry) : impact on practice. EFORT Open Reviews, 4(6), 377-390. View this article in WRRO
- Estimating patient-specific mortality after joint replacement: algorithm development and validation using national audit datasets. Osteoarthritis and Cartilage, 27, S229-S229.
- Genome-wide analyses using UK biobank data povide new therapeutic targets for osteoarthritis. Osteoarthritis and Cartilage, 27, S58-S59.
- The 2018 Otto Aufranc Award: How Does Genome-wide Variation Affect Osteolysis Risk After THA?. Clinical Orthopaedics and Related Research, 477(2), 297-309. View this article in WRRO
- Endogenous production of IL-1B by breast cancer cells drives metastasis and colonisation of the bone microenvironment.. Clinical Cancer Research, 25(9), 2769-2782. View this article in WRRO
- Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data. Nature Genetics, 51, 230-236. View this article in WRRO
- Temporal trends and survivorship of total hip arthroplasty in very young patients. The Bone & Joint Journal, 100-B(10), 1320-1329. View this article in WRRO
- Estimating an Individual's Probability of Revision Surgery After Knee Replacement: A Comparison of Modeling Approaches Using a National Dataset. American Journal of Epidemiology, 187(10), 2252-2262. View this article in WRRO
- Erratum: The risk of cardiac failure following metal-on-metal hip arthroplasty (Bone and Joint Journal (2018) 100-B (20-27) DOI: 10.1302/0301-620X.100B1.BJJ-2017-1065.R1). Bone and Joint Journal, 100B(9), 1260-1260.
- Genome-wide association study of developmental dysplasia of the hip identifies an association with GDF5. Communications Biology, 1. View this article in WRRO
- Regenerative medicine will make orthopaedic implants obsolete in our time Orthopaedic Research Society first annual meeting debate, San Diego, March 21st, 2017.. J Orthop Res. View this article in WRRO
- Widespread epigenomic, transcriptomic and proteomic differences between hip osteophytic and articular chondrocytes in osteoarthritis.. Rheumatology. View this article in WRRO
- Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis. Nature Genetics, 50(4), 549-558. View this article in WRRO
- A novel variant in GLIS3 is associated with osteoarthritis. Annals of the Rheumatic Diseases, 77(4), 620-623. View this article in WRRO
- The risk of cardiac failure following metal-on-metal hip arthroplasty. The Bone & Joint Journal, 100-B(1), 20-27. View this article in WRRO
- An analysis of 30-day mortality after weekend versus weekday elective joint arthroplasty in England and Wales: A cohort study using the national joint registry dataset. Bone and Joint Journal, 99B(12), 1618-1628. View this article in WRRO
- Integrative epigenomics, transcriptomics and proteomics of patient chondrocytes reveal genes and pathways involved in osteoarthritis. Scientific Reports, 7(1). View this article in WRRO
- Quantitating the effect of prosthesis design on femoral remodeling using high-resolution region-free densitometric analysis (DXA-RFA). Journal of Orthopaedic Research, 35(10), 2203-2210. View this article in WRRO
- Effects of chronic cobalt and chromium exposure after metal-on-metal hip resurfacing: An epigenome-wide association pilot study. Journal of Orthopaedic Research, 35(10), 2323-2328. View this article in WRRO
- Evaluation of shared genetic aetiology between osteoarthritis and bone mineral density identifies SMAD3 as a novel osteoarthritis risk locus. Human Molecular Genetics, 26(19), 3850-3858. View this article in WRRO
- Pathways to understanding the genomic aetiology of osteoarthritis. Human Molecular Genetics. View this article in WRRO
- Quantifying Pelvic Periprosthetic Bone Remodeling Using Dual-Energy X-Ray Absorptiometry Region-Free Analysis. Journal of Clinical Densitometry. View this article in WRRO
- Radiographic endophenotyping in hip osteoarthritis improves the precision of genetic association analysis. Annals of the Rheumatic Diseases, 76, 1199-1206. View this article in WRRO
- EPIDEMIOLOGYE20. REVISION RATES AND POSTOPERATIVE MORTALITY FOLLOWING TOTAL HIP REPLACEMENT IN PATIENTS WITH RHEUMATOID COMPARED TO OSTEOARTHRITIS: AN ANALYSIS OF DATA FROM THE NATIONAL JOINT REGISTRY FOR ENGLAND, WALES AND NORTHERN IRELAND. Rheumatology, 56(suppl_2).
- E21. REVISION RATES AND POSTOPERATIVE MORTALITY FOLLOWING TOTAL KNEE REPLACEMENT IN PATIENTS WITH RHEUMATOID COMPARED TO OSTEOARTHRITIS: AN ANALYSIS OF DATA FROM THE NATIONAL JOINT REGISTRY FOR ENGLAND, WALES AND NORTHERN IRELAND. Rheumatology, 56(suppl_2).
- Rates of hip and knee joint replacement amongst different ethnic groups in England: an analysis of National Joint Registry data. Osteoarthritis and Cartilage. View this article in WRRO
- Osteocyte physiology and response to fluid shear stress are impaired following exposure to cobalt and chromium: Implications for bone health following joint replacement.. Journal of Orthopaedic Research. View this article in WRRO
- Replication of Associations of Genetic Loci Outside the HLA Region With Susceptibility to Anti-Cyclic Citrullinated Peptide-Negative Rheumatoid Arthritis. Arthritis & Rheumatology, 68(7), 1603-1613. View this article in WRRO
- Good outcome of total hip replacement in patients with cerebral palsy. Acta Orthopaedica, 87(2), 93-99. View this article in WRRO
- Particle-Induced Osteolysis Is Mediated by TIRAP/Mal in Vitro and in Vivo. The Journal of Bone and Joint Surgery, 98(4), 285-294.
- Expression of Cannabinoid Receptors in Human Osteoarthritic Cartilage: Implications for Future Therapies. Cannabis and Cannabinoid Research, 1(1), 3-15. View this article in WRRO
- The Genetic Epidemiological Landscape of Hip and Knee Osteoarthritis: Where Are We Now and Where Are We Going?. The Journal of Rheumatology, 43(2), 260-266.
- Histone deacetylase 1 regulates tissue destruction in rheumatoid arthritis. Human Molecular Genetics, 24(19), 5367-5377. View this article in WRRO
- Human breast cancer bone metastasis in vitro and in vivo: a novel 3D model system for studies of tumour cell-bone cell interactions. Clinical & Experimental Metastasis, 32(7), 689-702. View this article in WRRO
- Investigation of Association Between Hip Osteoarthritis Susceptibility Loci and Radiographic Proximal Femur Shape. Arthritis & Rheumatology, 67(8), 2076-2084. View this article in WRRO
- Diagnostic Accuracy of Bone Turnover Markers as a Screening Tool for Aseptic Loosening after Total Hip Arthroplasty. HIP International, 25(6), 525-530.
- Cobalt and chromium exposure affects osteoblast function and impairs the mineralization of prosthesis surfaces in vitro. Journal of Orthopaedic Research, 33(11), 1663-1670. View this article in WRRO
- Genetic variation in inflammatory and bone turnover pathways and risk of osteolytic responses to prosthetic materials. Journal of Orthopaedic Research, 33(2), 193-198. View this article in WRRO
- High-Spatial-Resolution Bone Densitometry with Dual-Energy X-ray Absorptiometric Region-free Analysis. Radiology, 274(2), 532-539. View this article in WRRO
- Use of high resolution dual-energy x-ray absorptiometry-region free analysis (DXA-RFA) to detect local periprosthetic bone remodeling events. Journal of Orthopaedic Research, 33(5), 712-716. View this article in WRRO
- A novel association between COMT and BDNF gene polymorphisms and likelihood of symptomatic dysphagia in older people. Neurogastroenterology & Motility, 27(9), 1223-1231.
- High-Spatial-Resolution Bone Densitometry with Dual-Energy X-ray Absorptiometric Region-free Analysis. Radiology, 275(1), 310-310.
- Understanding the tissue effects of tribo-corrosion: Uptake, distribution, and speciation of cobalt and chromium in human bone cells. Journal of Orthopaedic Research, 33(1), 114-121.
- Patient safety after partial and total knee replacement. The Lancet, 384(9960), 2106-2106.
- Systemic toxicity related to metal hip prostheses. Clinical Toxicology, 52(8), 837-847.
- Brain structure and function in patients after metal-on-metal hip resurfacing.. AJNR Am J Neuroradiol, 35(9), 1753-1758.
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- Statistical shape and appearance models in osteoporosis.. Curr Osteoporos Rep, 12(2), 163-173.
- Assessment of osteoarthritis candidate genes in a meta-analysis of nine genome-wide association studies. Arthritis and Rheumatology, 66(4), 940-949. View this article in WRRO
- Cannabinoid WIN-55,212-2 mesylate inhibits interleukin-1β induced matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase expression in human chondrocytes.. Osteoarthritis Cartilage, 22(1), 133-144.
- Auditory and visual health after ten years of exposure to metal-on-metal hip prostheses: a cross-sectional study follow up.. PLoS One, 9(3), e90838. View this article in WRRO
- A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip. Annals of the Rheumatic Diseases, 73(12), 2130-2136. View this article in WRRO
- A TNF Variant that Associates with Susceptibility to Musculoskeletal Disease Modulates Thyroid Hormone Receptor Binding to Control Promoter Activation. PLoS ONE, 8(9). View this article in WRRO
- Development of a fully automatic shape model matching (FASMM) system to derive statistical shape models from radiographs: application to the accurate capture and global representation of proximal femur shape.. Osteoarthritis Cartilage, 21(10), 1537-1544.
- Quantifying the characteristics of the acetabulum and proximal femur using a semi-automated hip morphology software programme (SHIPS).. Hip Int, 23(3), 330-336.
- THU0004 The Role of Histone Deacetylases in Rheumatoid Arthritis Fibroblasts-Like Synoviocytes. Annals of the Rheumatic Diseases, 72(Suppl 3), A165.4-A166.
- THE ROLE OF HISTONE DEACETYLASES IN RHEUMATOID ARTHRITIS FIBROBLASTS-LIKE SYNOVIOCYTES. ANNALS OF THE RHEUMATIC DISEASES, 72, 165-166.
- Fully automatic segmentation of the proximal femur using random forest regression voting.. IEEE Trans Med Imaging, 32(8), 1462-1472.
- Effect of sliding-taper compared with composite-beam cemented femoral prosthesis loading regime on proximal femoral bone remodeling: a randomized clinical trial.. J Bone Joint Surg Am, 95(1), 19-27.
- Accurate bone segmentation in 2D radiographs using fully automatic shape model matching based on regression-voting. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), 8150 LNCS(PART 2), 181-189.
- Pelvic Periprosthetic Bone Mineral Density Measurement Around Cemented vs Cementless Acetabular Prostheses. Journal of Clinical Densitometry.
- Use of kernel-based Bayesian models to predict late osteolysis after hip replacement.. J R Soc Interface, 10(88), 20130678. View this article in WRRO
- Investigation of polarization-sensitive optical coherence tomography towards the study of microstructure of articular cartilage. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 8571.
- Metal-on-metal hip prostheses and systemic health: a cross-sectional association study 8 years after implantation.. PLoS One, 8(6), e66186. View this article in WRRO
- No evidence of an association between mitochondrial DNA variants and osteoarthritis in 7393 cases and 5122 controls. Annals of the Rheumatic Diseases, 72(1), 136-139. View this article in WRRO
- Evaluation of the genetic overlap between osteoarthritis with body mass index and height using genome-wide association scan data.. Ann Rheum Dis, 72(6), 935-941. View this article in WRRO
- Cannabinoids: novel therapies for arthritis?. Future Med Chem, 4(6), 713-725.
- Metal-on-metal hip prostheses: where are we now?. BMJ, 345, e7792.
- Identification of new susceptibility loci for osteoarthritis (arcOGEN): A genome-wide association study. The Lancet, 380(9844), 815-823.
- Use of the Sheffield Telescopic Intramedullary Rod System for the Management of Osteogenesis Imperfecta Clinical Outcomes at an Average Follow-up of Nineteen Years. JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 93A(21), 1994-2000.
- A Variant in MCF2L Is Associated with Osteoarthritis. AM J HUM GENET, 89(3), 446-450.
- Effects of cobalt and chromium ions at clinically equivalent concentrations after metal-on-metal hip replacement on human osteoblasts and osteoclasts: implications for skeletal health.. Bone, 49(4), 717-723. View this article in WRRO
- Bisphosphonates in orthopedic applications.. Bone, 49(1), 95-102.
- Insights into the genetic architecture of osteoarthritis from stage 1 of the arcOGEN study. Annals of the Rheumatic Diseases, 70(5), 864-867. View this article in WRRO
- The effect of genome-wide association scan quality control on imputation outcome for common variants. European Journal of Human Genetics, 19(5), 610-614. View this article in WRRO
- Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22. Annals of the Rheumatic Diseases, 70(2), 349-355.
- Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: The TREAT-OA consortium. Osteoarthritis and Cartilage, 19(3), 254-264.
- Long-term outcome of a cementless, hemispherical, press-fit acetabular component SURVIVORSHIP ANALYSIS AND DOSE-RESPONSE RELATIONSHIP TO LINEAR POLYETHYLENE WEAR. J BONE JOINT SURG BR, 92B(6), 856-861.
- Individual susceptibility to periprosthetic osteolysis is associated with altered patterns of innate immune gene expression in response to pro-inflammatory stimuli.. J Orthop Res, 28(9), 1127-1135.
- Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22. Annals of the Rheumatic Diseases.
- Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium. Osteoarthritis and Cartilage.
- Reply to letter by Gallo and Petrek commenting on interleukin-1 receptor antagonist and interleukin-6 polymorphisms and post-total hip arthroplasty osteolysis.. Arthritis Rheum, 60(12), 3856-3857.
- What potential biologic treatments are available for osteolysis?. Journal of the American Academy of Orthopaedic Surgeons, 16, S72-S75.
- Polymorphisms in the interleukin-1 receptor antagonist and interleukin-6 genes affect risk of osteolysis in patients with total hip arthroplasty.. Arthritis Rheum, 58(10), 3157-3165.
- Are there biological markers of wear?. Journal of the American Academy of Orthopaedic Surgeons, 16, S68-S71.
- How has the biologic reaction to wear particles changed with newer bearing surfaces?. Journal of the American Academy of Orthopaedic Surgeons, 16, S49-S55.
- What other biologic and mechanical factors might contribute to osteolysis?. Journal of the American Academy of Orthopaedic Surgeons, 16, S56-S62.
- Variation in the secreted frizzled-related protein-3 gene and risk of osteolysis and heterotopic ossification after total hip arthroplasty.. J Orthop Res, 25(12), 1665-1670.
- Hip and knee reconstruction in the rheumatoid patient. CURR ORTHOPAED, 21(5), 330-339.
- The pathogenesis of osteolysis and implant loosening. CALCIFIED TISSUE INT, 80, S17-S17.
- Urinary catheter tamponade to control intra-operative bleeding from the superior gluteal artery: a case report.. J Bone Joint Surg Br, 89(1), 32-33.
- Clinical and radiological outcome of total hip replacement five years after pamidronate therapy. A trial extension.. J Bone Joint Surg Br, 88(10), 1309-1315.
- Precision of periprosthetic bone mineral density measurements using Hologic Windows versus DOS-based analysis software.. J Clin Densitom, 9(3), 363-366.
- Bone remodelling around a cemented polyethylene cup. A longitudinal densitometry study.. J Bone Joint Surg Br, 88(4), 455-459.
- Accuracy of joint aspiration for the preoperative diagnosis of infection in total hip arthroplasty.. J Arthroplasty, 21(2), 221-226.
- Effect of bisphosphonates on periprosthetic bone mineral density after total joint arthroplasty.. J Bone Joint Surg Am, 87(11), 2589-2590.
- EBRA-digital release 2003 versus 1998: A comparison of instrument repeatability for measuring implant migration and wear. HIP INT, 15(4), 226-229.
- Polyethylene wear rate and osteolysis: critical threshold versus continuous dose-response relationship.. J Orthop Res, 23(3), 520-525.
- EBRA-Digital release 2003 versus 1998: A comparison of instrument repeatability for measuring implant migration and wear. HIP International, 15(4), 226-229.
- Effect of pamidronate on bone turnover and implant migration after total hip arthroplasty: a randomized trial.. J Orthop Res, 23(1), 1-8.
- Surgical management of the rheumatoid patient. CURR ORTHOPAED, 18(5), 357-370.
- Variation in the TNF gene promoter and risk of osteolysis after total hip arthroplasty.. J Bone Miner Res, 18(11), 1995-2001.
- Effect of pamidronate on excretion of pyridinium crosslinks of collagen after total hip arthroplasty.. Calcif Tissue Int, 73(4), 326-331.
- Bone mineral density and biochemical markers of bone turnover in aseptic loosening after total hip arthroplasty.. J Orthop Res, 21(4), 691-696.
- Biochemical markers of bone turnover and development of heterotopic ossification after total hip arthroplasty.. J Orthop Res, 21(3), 529-534.
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- Abstracts from the 5TH EBRA Meeting: Migration and Wear after Total Hip Arthroplasty. HIP International, 13(1), 49-58.
- Experiences with the Plasmacup--early stability, wear, remodelling, and outcome.. Int Orthop, 27 Suppl 1, S16-S19.
- Midterm Outcome of the Plasma Cup in Total Hip Arthroplasty. HIP International, 12(2), 119-125.
- Direct plain radiographic methods versus EBRA-Digital for measuring implant migration after total hip arthroplasty.. J Arthroplasty, 17(7), 917-925.
- Precision of EBRA-Digital software for monitoring implant migration after total hip arthroplasty.. J Arthroplasty, 17(7), 910-916.
- Effect of pamidronate on periprosthetic bone turnover and implant stability after total hip arthoplasty. J BONE MINER RES, 17(7), 1328-1328.
- Bone mineral density and biochemical markers of bone turnover in aseptic loosening after total hip arthroplasty. J BONE MINER RES, 17(7), 1337-1337.
- Promoter Region Polymorphism in the TNF Gene and Risk of Osteolysis after Total Hip Arthroplasty. Clinical Science, 103(s47), 50P-50P.
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- Letters to the editor (multiple letters). Journal of Pediatric Orthopaedics, 22(2), 274.
- Risk of loosening after total hip arthroplasty and single nucleotide polymorphisms in the promoter region of the tumour necrosis factor gene.. J BONE MINER RES, 16, S474-S474.
- Posterior surgical approaches to the elbow: a comparative anatomic study.. J Shoulder Elbow Surg, 10(4), 380-382.
- Prevention of postoperative wound haematomas and hyperperfusion following carotid endarterectomy.. Eur J Vasc Endovasc Surg, 21(6), 490-493.
- Measuring bone mineral density of the pelvis and proximal femur after total hip arthroplasty. The Journal of Bone and Joint Surgery. British volume, 83-B(2), 283-288.
- Effect of pamidronate in preventing local bone loss after total hip arthroplasty: a randomized, double-blind, controlled trial.. J Bone Miner Res, 16(3), 556-564.
- Measuring bone mineral density of the pelvis and proximal femur after total hip arthroplasty.. J Bone Joint Surg Br, 83(2), 283-288.
- A comparison between ELISA and HPLC for measuring total and free urinary deoxypyridinoline.. J BONE MINER RES, 15, S406-S406.
- Early measurement of biochemical markers of bone turnover predict femoral bone loss and response to pamidronate therapy following total hip arthroplasty.. J BONE MINER RES, 15, S432-S432.
- Effect of mixing technique on the properties of acrylic bone-cement: a comparison of syringe and bowl mixing systems.. J Arthroplasty, 15(5), 663-667.
- Effect of bisphosphonate on excretion of free and peptide-bound pyridinium crosslinks of collagen after total hip arthroplasty.. J BONE MINER RES, 15(6), 1226-1226.
- Pamidronate prevents periprosthetic bone loss after total hip arthroplasty. OSTEOPOROSIS INT, 11, S27-S27.
- Monitoring femoral periprosthetic BMD change following cemented total hip arthroplasty: Influence of bone cement on longitudinal BMD measurement.. J BONE MINER RES, 14, S340-S340.
- Monitoring BMD changes around the acetabular prosthetic component following total hip arthroplasty.. J BONE MINER RES, 14, S339-S339.
- Measurement of pelvic periprosthetic BMD following total hip arthroplasty: Analysis protocols and repeatability.. J BONE MINER RES, 14(6), 1042-1042.
- Surgical stabilisation of the lower limb in osteogenesis imperfecta using the Sheffield Telescopic Intramedullary Rod System.. J Bone Joint Surg Br, 80(6), 999-1004.
- Middle cerebral artery blood velocity, embolisation, and neurological outcome during carotid endarterectomy: a prospective comparison of the Javid and the Pruitt-Inahara shunts.. Eur J Vasc Endovasc Surg, 14(5), 399-402.
- Successful non operative management of late infrainguinal polytetrafluoroethylene vascular graft infection with antibiotics alone: a report of two cases.. Panminerva Med, 39(2), 128-131.
- Acute bicaval obstruction as a result of intracapsular haemorrhage in a right atrial myxoma: report of a case.. Eur J Cardiothorac Surg, 11(4), 779-781.
- THE PROGNOSIS FOR WALKING IN OSTEOGENESIS IMPERFECTA. The Journal of Bone and Joint Surgery. British volume, 79-B(2), 339-339.
- The prognosis for walking in osteogenesis imperfecta. J BONE JOINT SURG BR, 79B(2), 339-339.
- Supravesical diversion for incontinence: a long-term follow-up.. Br J Urol, 79(3), 348-353.
- Diagnostic dilemmas in dysphagia aortica.. Eur J Cardiothorac Surg, 11(2), 222-227.
- Aortoiliac occlusion treated by a combination of aortoiliac stent and femorofemoral crossover grafting.. Eur J Vasc Endovasc Surg, 12(3), 372-374.
- Spinal cord schwannoma after vertebral trauma: a causal relation?. J Neurol Neurosurg Psychiatry, 59(4), 358.
- DISPOSABLE VERSUS REUSABLE LAPAROSCOPIC CHOLECYSTECTOMY INSTRUMENTS - AN AUDIT OF COSTS. MINIMAL INVASIV THER, 4(4), 211-214.
- LONG-TERM RESULTS OF HIGHLY SELECTIVE VAGOTOMY - A PROSPECTIVE-STUDY WITH IMPLICATIONS FOR FUTURE LAPAROSCOPIC SURGERY - REPLY. BRIT J SURG, 82(3), 421-421.
- Rotaflex total knee arthroplasty: a report of two prosthetic failures at the hinge mechanism.. J R Coll Surg Edinb, 39(6), 375-376.
- Advanced gastrointestinal malignancy or benign inflammatory disease? An unusual presentation of sclerosing mesenteritis. Report of a case.. Dis Colon Rectum, 37(11), 1155-1157.
- Long-term results of highly selective vagotomy: a prospective study with implications for future laparoscopic surgery.. Br J Surg, 81(10), 1469-1471.
- PRIMARY COMPONENT FRACTURE IN THE STANMORE TOTAL KNEE REPLACEMENT - A CASE-REPORT AND LITERATURE-REVIEW. J ORTHOP RHEUMATOL, 7(3), 169-171.
- Preoperative location of a lesion with a guide-wire under ultrasonic control: an alternative to intraoperative fluoroscopy. A case report.. J Bone Joint Surg Am, 76(4), 602-604.
- OBSTRUCTED DEFECATION BECAUSE OF ADULT SACROCOCCYGEAL TERATOMA. LANCET, 340(8830), 1287-1288.
- Assessment of osteoporosis at autopsy: mechanical methods compared to radiological and histological techniques.. Med Sci Law, 31(1), 19-24.
- ASSESSMENT OF OSTEOPOROSIS AT AUTOPSY - MECHANICAL METHODS COMPARED TO RADIOLOGICAL AND HISTOLOGICAL TECHNIQUES. J PATHOL, 160(2), A175-A175.
- The Effects of Computer Navigation and Patient-Specific Instrumentation on Risk of Revision, PROMs, and Mortality Following Primary TKR. Journal of Bone and Joint Surgery.
- The Risk of Postoperative Periprosthetic Femoral Fracture After Total Hip Arthroplasty Depends More on Stem Design Than Cement Use. Journal of Bone and Joint Surgery.
- The incidence of postoperative periprosthetic femoral fracture following total hip replacement: An analysis of UK National Joint Registry and Hospital Episodes statistics data. PLOS Medicine, 21(10), e1004462-e1004462.
- The potential therapeutic applications of long non-coding RNAs. Journal of Translational Genetics and Genomics, 8(2), 225-43.
- Periprosthetic Joint Infection After Total Knee Arthroplasty With or Without Antibiotic Bone Cement. JAMA Network Open, 7(5), e2412898-e2412898.
- Epigenomic profiling of the infrapatellar fat pad in osteoarthritis. Human Molecular Genetics.
- Cementing Techniques In Knee Surgery (CeTIKS): a UK expert consensus study. Bone & Joint Open, 4(9), 682-688.
- The use of antibiotic-loaded bone cement and systemic antibiotic prophylactic use in 2,971,357 primary total knee arthroplasties from 2010 to 2020: an international register-based observational study among countries in Africa, Europe, North America, and Oceania. Acta Orthopaedica, 94, 416-425.
- What effect have commissioners’ policies for body mass index had on hip replacement surgery?: an interrupted time series analysis from the National Joint Registry for England. BMC Medicine, 21(1).
- A
GWAS meta‐analysis of alpha angle suggests cam‐type morphology may be a specific feature of hip osteoarthritis in older adults. Arthritis & Rheumatology.
- The Kinesin Gene KIF26B Modulates the Severity of Post-Traumatic Heterotopic Ossification. International Journal of Molecular Sciences, 23(16), 9203-9203.
- A molecular map of long non-coding RNA expression, isoform switching and alternative splicing in osteoarthritis. Human Molecular Genetics.
- British Society for Rheumatology and British Health Professionals in Rheumatology guideline for the management of rheumatoid arthritis (after the first 2 years). Rheumatology, 48(4), 436-439.
- The genetic epidemiology of joint shape and the development of osteoarthritis. Calcified Tissue International. View this article in WRRO
- Genome-wide association and functional analyses identify CASC20 and KIF26B as target loci in heterotopic ossification.
- The Genetic Epidemiology of Developmental Dysplasia of the Hip: A Genome-Wide Association Study Harnessing National Clinical Audit Data.
- Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank.
- Genetic and epigenetic interplay regulates
COLGALT2,
contributing to osteoarthritis genetic risk. Arthritis & Rheumatology.
Chapters
- Aetiology of Hip Dysplasia: Genetic and Environmental Factors, Hip Dysplasia (pp. 1-15). Springer International Publishing
- Risk Factors for Aseptic Loosening Following Total Hip Arthroplasty, Recent Advances in Arthroplasty InTech
Conference proceedings papers
- OP87 What effect have clinical commissioning group policies for thresholds of weight loss and body mass index had on access to knee replacement surgery in England?: an analysis from the national joint registry for England*. SSM Annual Scientific Meeting
- WHAT EFFECT HAVE CLINICAL COMMISSIONING GROUP POLICIES FOR THRESHOLDS OF WEIGHT LOSS AND BODY MASS INDEX HAD ON ACCESS TO KNEE REPLACEMENT SURGERY IN ENGLAND? AN ANALYSIS FROM THE NATIONAL JOINT REGISTRY FOR ENGLAND. AGING CLINICAL AND EXPERIMENTAL RESEARCH, Vol. 34(SUPPL 1) (pp S363-S363)
- An epigenome-wide view of osteoarthritis in primary tissues. EUROPEAN JOURNAL OF HUMAN GENETICS, Vol. 30(SUPPL 1) (pp 66-67)
- A molecular map of long non-coding RNA expression, isoform switching and alternative splicing in osteoarthritis. EUROPEAN JOURNAL OF HUMAN GENETICS, Vol. 30(SUPPL 1) (pp 557-557)
- A comprehensive transcriptional map of knee osteoarthritis. Osteoarthritis and Cartilage, Vol. 28(Suppl 1) (pp S346-S346). Vienna, Austria, 30 April 2020 - 3 May 2020. View this article in WRRO
- Epigenome-wide association study in knee osteoarthritis generates novel insights into disease mechanisms. EUROPEAN JOURNAL OF HUMAN GENETICS, Vol. 28(SUPPL 1) (pp 751-752)
- Effect of Denosumab on Osteoclast Activity within Osteolytic Lesions after Total Hip Arthroplasty: A Proof of Concept Trial. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 35 (pp 171-171)
- A comprehensive transcriptional map of knee osteoarthritis. EUROPEAN JOURNAL OF HUMAN GENETICS, Vol. 28(SUPPL 1) (pp 752-752)
- A Comprehensive Transcriptional Map of Knee Osteoarthritis. HUMAN HEREDITY, Vol. 84(4-5) (pp 213-213)
- Propensity score stratification and inverse probability weighting compared to surgical randomized clinical trial results in device epidemiology. Pharmacoepidemiology and Drug Safety, Vol. 28(Supp 2) (pp 431-431). Philadelphia, PA, USA, 24 August 2019 - 28 August 2019. View this article in WRRO
- The performance of preference-based instrumental variables to emulate a randomized clinical trial of comparative medical device effectiveness. Pharmacoepidemiology and Drug Safety, Vol. 28(Supp 2) (pp 431-432), 24 August 2019 - 28 August 2019. View this article in WRRO
- The long non-coding RNA CASC20 is a susceptibility locus for heterotopic ossification: results of a genome-wide association study. Osteoarthritis and Cartilage, Vol. 26 (pp S156-S156)
- Causal effects for higher body mass index, but not for triglyceride levels or genetic predisposition to type 2 diabetes, on osteoarthritis. Osteoarthritis and Cartilage, Vol. 26 (pp S29-S30)
- An evaluation of survival modelling approaches for personalised risk prediction after hip replacement for osteoarthritis. Osteoarthritis and Cartilage, Vol. 26(Supplement 1) (pp S281-S281). Liverpool, United Kingdom, 26 April 2018 - 29 April 2018.
- Spatio-Temporal Atlas of Bone Mineral Density Ageing (pp 720-728)
- Molecular phenotyping of patient chondrocytes reveals genes and pathways involved in osteoarthritis. Osteoarthritis and Cartilage, Vol. 25 (pp S209-S210)
- REVISION RATES AND POSTOPERATIVE MORTALITY FOLLOWING TOTAL KNEE REPLACEMENT IN PATIENTS WITH RHEUMATOID COMPARED TO OSTEOARTHRITIS: AN ANALYSIS OF DATA FROM THE NATIONAL JOINT REGISTRY FOR ENGLAND, WALES AND NORTHERN IRELAND. RHEUMATOLOGY, Vol. 56 (pp 193-194)
- REVISION RATES AND POSTOPERATIVE MORTALITY FOLLOWING TOTAL HIP REPLACEMENT IN PATIENTS WITH RHEUMATOID COMPARED TO OSTEOARTHRITIS: AN ANALYSIS OF DATA FROM THE NATIONAL JOINT REGISTRY FOR ENGLAND, WALES AND NORTHERN IRELAND. RHEUMATOLOGY, Vol. 56 (pp 193-193)
- Identification of five novel osteoarthritis susceptibility loci through the UK biobank resourse of five novel osteoarthritis susceptibility loci through the UK biobank resourse. Osteoarthritis and Cartilage, Vol. 25 (pp S38-S39)
- National clinical audit data decodes the genetic architecture of developmental dysplasia of the hip. Osteoarthritis and Cartilage, Vol. 25 (pp S36-S37), 27 April 2017 - 30 April 2017. View this article in WRRO
- Automatic Quality Control for Population Imaging: A Generic Unsupervised Approach (pp 291-299)
- Improved phenotype definitions of OA in genetic association studies highlight a structural role for a common variant in LRCH1. Osteoarthritis and Cartilage, Vol. 23 (pp A70-A70)
- FRI0360 Histone Deacetylase One Contributes to the Auto-Aggressive Phenotype of Rheumatoid Arthritis Synovial Fibroblasts. Annals of the Rheumatic Diseases, Vol. 73(Suppl 2) (pp 517.2-517)
- INVESTIGATION OF THE ROLE OF HISTONE DEACETYLASES IN RHEUMATOID ARTHRITIS SYNOVIAL FIBROBLASTS. RHEUMATOLOGY, Vol. 53 (pp 85-85)
- POWERFUL DETECTION OF OSTEOARTHRITIS SUSCEPTIBILITY LOCI BY COMPREHENSIVE EXAMINATION OF CLINICALLY IMPORTANT ENDOPHENOTYPES. OSTEOARTHRITIS AND CARTILAGE, Vol. 22 (pp S232-S232)
- Investigation Of The Role Of Histone Deacetylases In Rheumatoid Arthritis Synovial Fibroblasts. ARTHRITIS AND RHEUMATISM, Vol. 65 (pp S1035-S1036)
- Investigation of the role of histone deacetylases in rheumatoid arthritis synovial fibroblasts. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Vol. 94(5) (pp A3-A3)
- INVESTIGATION OF THE ROLE OF HISTONE DEACETYLASES IN RHEUMATOID ARTHRITIS SYNOVIAL FIBROBLASTS. RHEUMATOLOGY, Vol. 52 (pp 79-80)
- Accurate Fully Automatic Femur Segmentation in Pelvic Radiographs Using Regression Voting (pp 353-360)
- The effect of cobalt and chromium ions at clinically relevant concentrations on human osteoblast and osteoclast physiology in vitro: implications for skeletal health. Bone, Vol. 46 (pp S71-S71)
- What are the local and systemic biologic reactions and mediators to wear debris, and what host factors determine or modulate the biologic response to wear particles?. JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS, Vol. 16 (pp S42-S48)
- Polymorphisms in the interleukin-one gene cluster and the risk of aseptic loosening after total hip arthroplasty.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 18 (pp S326-S326)
- A single nucleotide polymorphism at-238 in the TNF gene influences promoter activity in-vitro. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 17 (pp S237-S237)
Other
- Supplementary figure 2 from Endogenous Production of IL1B by Breast Cancer Cells Drives Metastasis and Colonization of the Bone Microenvironment.
- Supplementary figure legends from Endogenous Production of IL1B by Breast Cancer Cells Drives Metastasis and Colonization of the Bone Microenvironment.
- Supplementary figure 5 from Endogenous Production of IL1B by Breast Cancer Cells Drives Metastasis and Colonization of the Bone Microenvironment.
- Supplementary figure 3 from Endogenous Production of IL1B by Breast Cancer Cells Drives Metastasis and Colonization of the Bone Microenvironment.
- Supplementary table 1 from Endogenous Production of IL1B by Breast Cancer Cells Drives Metastasis and Colonization of the Bone Microenvironment.
- Supplementary figure 1 from Endogenous Production of IL1B by Breast Cancer Cells Drives Metastasis and Colonization of the Bone Microenvironment.
- Supplementary figure 4 from Endogenous Production of IL1B by Breast Cancer Cells Drives Metastasis and Colonization of the Bone Microenvironment.
- Supplementary figure 1 from Endogenous Production of IL1B by Breast Cancer Cells Drives Metastasis and Colonization of the Bone Microenvironment.
- Supplementary figure 4 from Endogenous Production of IL1B by Breast Cancer Cells Drives Metastasis and Colonization of the Bone Microenvironment.
- Data from Endogenous Production of IL1B by Breast Cancer Cells Drives Metastasis and Colonization of the Bone Microenvironment.
- Supplementary figure 6 from Endogenous Production of IL1B by Breast Cancer Cells Drives Metastasis and Colonization of the Bone Microenvironment.
- Supplementary figure 7 from Endogenous Production of IL1B by Breast Cancer Cells Drives Metastasis and Colonization of the Bone Microenvironment.
- Supplementary figure 5 from Endogenous Production of IL1B by Breast Cancer Cells Drives Metastasis and Colonization of the Bone Microenvironment.
- Supplementary figure 6 from Endogenous Production of IL1B by Breast Cancer Cells Drives Metastasis and Colonization of the Bone Microenvironment.
- Data from Endogenous Production of IL1B by Breast Cancer Cells Drives Metastasis and Colonization of the Bone Microenvironment.
- Supplementary figure 7 from Endogenous Production of IL1B by Breast Cancer Cells Drives Metastasis and Colonization of the Bone Microenvironment.
- Supplementary figure legends from Endogenous Production of IL1B by Breast Cancer Cells Drives Metastasis and Colonization of the Bone Microenvironment.
- Supplementary table 1 from Endogenous Production of IL1B by Breast Cancer Cells Drives Metastasis and Colonization of the Bone Microenvironment.
- Supplementary figure 3 from Endogenous Production of IL1B by Breast Cancer Cells Drives Metastasis and Colonization of the Bone Microenvironment.
- Supplementary figure 2 from Endogenous Production of IL1B by Breast Cancer Cells Drives Metastasis and Colonization of the Bone Microenvironment.
Preprints
- Transcriptome regulation analysis in osteoarthritis primary tissues identifies high-confidence effector genes, Cold Spring Harbor Laboratory.
- Epigenomic profiling of the infrapatellar fat pad in osteoarthritis, Cold Spring Harbor Laboratory.
- Metaparametric Neural Networks for Survival Analysis, arXiv.
- Investigation of the genetic architecture of cam morphology, and its relationship with hip osteoarthritis, using alpha angle as a proxy measure, Cold Spring Harbor Laboratory.
- Ubiquitinome analysis of articular cartilage post mechanical injury reveals a differential ubiquitination pattern of a subset of DUBs and proteins linked to the ERAD cellular response, Cold Spring Harbor Laboratory.
- Effect of Denosumab on Osteolytic Lesion Activity after Total Hip Arthroplasty: A Single-Centre, Randomised, Double-Blind, Placebo-Controlled, Proof-of-Concept Study.
- Decoding the genomic basis of osteoarthritis, Cold Spring Harbor Laboratory.
- Accelerating functional gene discovery in osteoarthritis, Cold Spring Harbor Laboratory.
- The genetic architecture of osteoarthritis: insights from UK Biobank, Cold Spring Harbor Laboratory.
- Integrative epigenomics, transcriptomics and proteomics of patient chondrocytes reveal genes and pathways involved in osteoarthritis, Cold Spring Harbor Laboratory.
- The risk of all-cause mortality, heart outcomes, cancer, and neurodegenerative disorders with cobalt-chrome-containing total hip arthroplasty implants : an analysis of the National Joint Registry.. The Bone & Joint Journal, 1-9.
- Grants
-
- National Institutes of Health Research
- Arthritis Research UK
- Clinical Research Fellow (Jan 2000 – Oct 2001)
- John Charnley Trust
- Clinical Research Fellow (Jan 1999 – Dec 1999)
- Royal College of Surgeons of England
- Laming-Evans Clinical Research Fellow (Jan 1998 – Dec1998)
- Advanced Clinical Training Fellowships:
- 2006 Cavendish Hip Fellow, Northern General Hospital, Sheffield
- 2005 International Arthroplasty Fellow, Wrightington Hospital, Wigan, Lancs
- 2005 Zurich, Switzerland (arthroplasty)
- 2005 Toronto, Canada (revision arthroplasty)
- 2003 Multiple centres Japan, (rheumatoid surgery)
Principal funding sources
- Versus Arthritis
- National Institutes for Health Research
- Medical Research Council
- Charity
- Industry