Lydia Castelli

Journal articles

• Kershaw CJ, Nelson MG, Castelli LM, Jennings MD, Lui J, Talavera D, Grant CM, Pavitt GD, Hubbard SJ & Ashe MP (2023) Translation factor and RNA binding protein mRNA interactomes support broader RNA regulons for posttranscriptional control. Journal of Biological Chemistry, 299(10), 105195-105195.
• Castelli LM, Lin Y-H, Sanchez-Martinez A, Gül A, Mohd Imran K, Higginbottom A, Upadhyay SK, Márkus NM, Rua Martins R, Cooper-Knock J , Montmasson C et al (2023) A cell-penetrant peptide blocking C9ORF72 -repeat RNA nuclear export reduces the neurotoxic effects of dipeptide repeat proteins. Science Translational Medicine, 15(685).
• Moll T, Odon V, Harvey C, Collins MO, Peden A, Franklin J, Graves E, Marshall JNG, dos Santos Souza C, Zhang S , Castelli L et al (2023) Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication. Life Science Alliance, 6(1), e202201449-e202201449.
• Castelli LM, Benson BC, Huang W-P, Lin Y-H & Hautbergue GM (2022) RNA helicases in microsatellite repeat expansion disorders and neurodegeneration. Frontiers in Genetics, 13.
• Castelli LM, Cutillo L, Souza CDS, Sanchez-Martinez A, Granata I, Lin Y-H, Myszczynska MA, Heath PR, Livesey MR, Ning K , Azzouz M et al (2021) SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export : genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis. Molecular Neurodegeneration, 16(1). View this article in WRRO
• Nwokoye EC, AlNaseem E, Crawford RA, Castelli LM, Jennings MD, Kershaw CJ & Pavitt GD (2021) Overlapping regions of Caf20 mediate its interactions with the mRNA-5′cap-binding protein eIF4E and with ribosomes. Scientific Reports, 11(1).
• Gatto N, Dos Santos Souza C, Shaw AC, Bell SM, Myszczynska MA, Powers S, Meyer K, Castelli LM, Karyka E, Mortiboys H , Azzouz M et al (2020) Directly converted astrocytes retain the ageing features of the donor fibroblasts and elucidate the astrocytic contribution to human CNS health and disease. Aging Cell. View this article in WRRO
• Allen S, Hall B, Castelli L, Frances L, Woof R, Siskos A, Kouloura E, Gray E, Thompson A, Talbot K , Higginbottom A et al (2019) Astrocyte adenosine deaminase loss increases motor neuron toxicity in amyotrophic lateral sclerosis. Brain, 142(3), 586-605. View this article in WRRO
• Cooper-Knock J, Moll T, Ramesh T, Castelli L, Beer A, Robins H, Fox I, Niedermoser I, Van Damme P, Moisse M , Robberecht W et al (2019) Mutations in the Glycosyltransferase Domain of GLT8D1 Are Associated with Familial Amyotrophic Lateral Sclerosis. Cell Reports, 26(9), 2298-2306.e5. View this article in WRRO
• Ferraiuolo L, Varcianna AE, Myszczynska MA, Castelli LM, O'Neill B, Kim Y, Talbot J, Nyberg S, Nymali I, Heath PR , Stopford MJ et al (2019) Micro-RNAs secreted through astrocyte-derived extracellular vesicles cause neuronal network degeneration in C9orf72 ALS.. EBioMedicine, 40, 626-635. View this article in WRRO
• Shaw MP, Higginbottom A, Mcgown A, Castelli LM, James E, Hautbergue GM, Shaw PJ & Ramesh TM (2018) Stable transgenic C9orf72 zebrafish model key aspects of the ALS/FTD phenotype and reveal novel pathological features. Acta Neuropathologica Communications, 6(1). View this article in WRRO
• Morgan SV, Garwood CJ, Jennings L, Simpson JE, Castelli LM, Heath PR, Mihaylov SR, Vaquéz-Villaseñor I, Minshull TC, Ince PG , Dickman MJ et al (2018) Proteomic and cellular localisation studies suggest non-tight junction cytoplasmic and nuclear roles for occludin in astrocytes. European Journal of Neuroscience, 47(12), 1444-1456. View this article in WRRO
• Talavera D, Kershaw CJ, Costello JL, Castelli LM, Rowe W, Sims PFG, Ashe MP, Grant CM, Pavitt GD & Hubbard SJ (2018) Archetypal transcriptional blocks underpin yeast gene regulation in response to changes in growth conditions. Scientific Reports, 8(1). View this article in WRRO
• Castelli LM, Lin YH, Ferraiuolo L, Sanchez-Martinez A, Ning KE, Azzouz M, Whitworth A, Shaw PJ & Hautbergue GM (2018) SRSF1-dependent nuclear export of C9ORF72 repeat transcripts: targeting toxic gain-of-functions induced by protein sequestration as a selective therapeutic strategy for neuroprotection. Therapeutic Targets for Neurological Diseases, 4. View this article in WRRO
• Chandran JS, Sharp PS, Karyka E, Aves-Cruzeiro JMDC, Coldicott I, Castelli L, Hautbergue G, Collins MO & Azzouz M (2017) Site Specific Modification of Adeno-Associated Virus Enables Both Fluorescent Imaging of Viral Particles and Characterization of the Capsid Interactome. Scientific Reports, 7(1). View this article in WRRO
• Costello JL, Kershaw CJ, Castelli LM, Talavera D, Rowe W, Sims PFG, Ashe MP, Grant CM, Hubbard SJ & Pavitt GD (2017) Dynamic changes in eIF4F-mRNA interactions revealed by global analyses of environmental stress responses. Genome Biology, 18(1). View this article in WRRO
• Egbe NE, Dornelles TO, Paget CM, Castelli LM & Ashe MP (2017) Farnesol inhibits translation to limit growth and filamentation in C. albicans and S. cerevisiae. Microbial Cell, 4(9), 294-304. View this article in WRRO
• Hautbergue GM, Castelli LM, Ferraiuolo L, Sanchez-Martinez A, Cooper-Knock J, Higginbottom A, Lin YH, Bauer CS, Dodd JE, myszczynska MA , Alam SM et al (2017) SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits. Nature Communications, 8. View this article in WRRO
• Kershaw CJ, Costello JL, Talavera D, Rowe W, Castelli LM, Sims PFG, Grant CM, Ashe MP, Hubbard SJ & Pavitt GD (2015) Integrated multi-omics analyses reveal the pleiotropic nature of the control of gene expression by Puf3p. Scientific Reports, 5. View this article in WRRO
• Castelli LM, Talavera D, Kershaw CJ, Mohammad-Qureshi SS, Costello JL, Rowe W, Sims PFG, Grant CM, Hubbard SJ, Ashe MP & Pavitt GD (2015) The 4E-BP Caf20p Mediates Both eIF4E-Dependent and Independent Repression of Translation. PLOS Genetics, 11(5). View this article in WRRO
• Kershaw CJ, Costello JL, Castelli LM, Talavera D, Rowe W, Sims PFG, Ashe MP, Hubbard SJ, Pavitt GD & Grant CM (2015) The Yeast La Related Protein Slf1p Is a Key Activator of Translation during the Oxidative Stress Response. PLoS Genetics, 11(1). View this article in WRRO
• Costello J, Castelli LM, Rowe W, Kershaw CJ, Talavera D, Mohammad-Qureshi SS, Sims PFG, Grant CM, Pavitt GD, Hubbard SJ & Ashe MP (2015) Global mRNA selection mechanisms for translation initiation. Genome Biology, 16. View this article in WRRO
• Lui J, Castelli LM, Pizzinga M, Simpson CE, Hoyle NP, Bailey KL, Campbell SG & Ashe MP (2014) Granules Harboring Translationally Active mRNAs Provide a Platform for P-Body Formation following Stress. Cell Reports, 9(3), 944-954.
• Rowe W, Kershaw CJ, Castelli LM, Costello JL, Ashe MP, Grant CM, Sims PFG, Pavitt GD & Hubbard SJ (2014) Puf3p induces translational repression of genes linked to oxidative stress. Nucleic Acids Research, 42(2), 1026-1041. View this article in WRRO
• Tudisca V, Simpson C, Castelli L, Lui J, Hoyle N, Moreno S, Ashe M & Portela P (2012) PKA isoforms coordinate mRNA fate during nutrient starvation. Journal of Cell Science, 125(21), 5221-5232.
• Castelli LM, Lui J, Campbell SG, Rowe W, Zeef LAH, Holmes LEA, Hoyle NP, Bone J, Selley JN, Sims PFG & Ashe MP (2011) Glucose depletion inhibits translation initiation via eIF4A loss and subsequent 48S preinitiation complex accumulation, while the pentose phosphate pathway is coordinately up-regulated. Molecular Biology of the Cell, 22(18), 3379-3393. View this article in WRRO
• Cridge AG, Castelli LM, Smirnova JB, Selley JN, Rowe W, Hubbard SJ, McCarthy JEG, Ashe MP, Grant CM & Pavitt GD (2010) Identifying eIF4E-binding protein translationally-controlled transcripts reveals links to mRNAs bound by specific PUF proteins. Nucleic Acids Research, 38(22), 8039-8050. View this article in WRRO
• JONES JT, KUMAR A, PYLYPENKO LA, THIRUGNANASAMBANDAM A, CASTELLI L, CHAPMAN S, COCK PJA, GRENIER E, LILLEY CJ, PHILLIPS MS & BLOK VC (2009) Identification and functional characterization of effectors in expressed sequence tags from various life cycle stages of the potato cyst nematodeGlobodera pallida. Molecular Plant Pathology, 10(6), 815-828.
• Hoyle NP, Castelli LM, Campbell SG, Holmes LEA & Ashe MP (2007) Stress-dependent relocalization of translationally primed mRNPs to cytoplasmic granules that are kinetically and spatially distinct from P-bodies. The Journal of Cell Biology, 179(1), 65-74. View this article in WRRO
• Castelli L, Bryan G, Blok VG, Ramsay G, Sobczak M, Gillespie T & Phillips MS (2006) Investigations of Globodera pallida invasion and syncytia formation within roots of the susceptible potato cultivar Désirée and resistant species Solanum canasense. Nematology, 8(1), 103-110.
• Ramsay G, Bryan G, Castelli L, Phillips M & Blok V (2005) Investigation of resistance specificity amongst fifteen wild Solanum species to a range of Globodera pallida and G. rostochiensis populations. Nematology, 7(5), 689-699.
• Blok V, Bryan G, Phillips M, Castelli L & Ramsay G (2005) Life stage responses observed amongst fifteen wild Solanum species resistant to Globodera pallida. Nematology, 7(5), 701-711.
• Castelli L, Ramsay G, Bryan G, Neilson SJ & Phillips MS (2003) . Euphytica, 129(3), 377-386.
• Bryan G, McLean K, Bradshaw J, De Jong W, Phillips M, Castelli L & Waugh R (2002) Mapping QTLs for resistance to the cyst nematode Globodera pallida derived from the wild potato species Solanum vernei. Theoretical and Applied Genetics, 105(1), 68-77.
• Cooper‐Knock J, Julian TH, Feneberg E, Highley JR, Sidra M, Turner MR, Talbot K, Ansorge O, Allen SP, Moll T , Shelkovnikova T et al () Atypical TDP ‐43 protein expression in an ALS pedigree carrying a p. Y374X truncation mutation in TARDBP. Brain Pathology.
• Castelli LM, Huang W-P, Lin Y-H, Chang K-Y & Hautbergue GM () Mechanisms of repeat-associated non-AUG translation in neurological microsatellite expansion disorders. Biochemical Society Transactions.

Conference proceedings papers

• Cooper-Knock J, Moll T, Ramesh T, Castelli L, Shaw C, Al-Chalabi A, McDermott C, Hautbergue G & Shaw P (2019) 11.30 Mutations in the glycosyltransferase domain of GLT8D1 cause ALS. Journal of Neurology Neurosurgery & Psychiatry, Vol. 90(12) (pp e10)
• Cooper-Knock J, Moll T, Ramesh T, Castelli L, Shaw C, Al-Chalabi A, McDermott C, Hautbergue G & Shaw P (2019) MUTATIONS IN THE GLYCOSYLTRANSFERASE DOMAIN OF GLT8D1 CAUSE ALS. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol. 90(12) (pp E20-E21)
• Alves-Cruzeiro J, Karyka E, Bauer C, Coldicott I, Hautbergue G, Webster C, Castelli L, Simon S, Myszczynska M, Ferraiuolo L & Azzouz M (2019) AAV-mediated gene editing as a potential therapeutic approach for C9ORF72-linked ALS/FTD. HUMAN GENE THERAPY, Vol. 30(11) (pp A96-A96)
• Allen SP, Hall B, Castelli L, Francis L, Woof R, Higginbottom A, Myszczynska M, Allen CF, Stopford MJ, Webster CP , De Vos K et al (2018) Inosine reverses motor neuron toxicity observed in amyotrophic lateral sclerosis patient astrocytes with an adenosine deaminase deficiency. Biochimica et Biophysica Acta (BBA) - Bioenergetics, Vol. 1859 (pp e23-e23)

Datasets

• Gatto N, Souza CDS, Bell S, Shaw A, Myszczynska M, Powers S, Meyer K, Heath P, Castelli L, Karyka E , Mortiboys H et al Directly converted astrocytes retain the ageing features of the donor fibroblasts and elucidate the astrocytic contribution to human CNS health and disease..

Preprints

• Burrows DJ, McGown A, Abduljabbar O, Castelli LM, Shaw PJ, Hautbergue GM & Ramesh TM (2024) RAN translation of C9ORF72-related dipeptide repeat proteins recapitulates hallmarks of motor neurone disease and identifies hypothermia as a therapeutic strategy in zebrafish, Cold Spring Harbor Laboratory.
• Mihaylov SR, Castelli LM, Lin Y-H, Gül A, Soni N, Hastings C, Flynn HR, Dickman MJ, Snijders AP, Bandmann O , Mortiboys H et al () The master energy homeostasis regulator PGC-1α couples transcriptional co-activation and mRNA nuclear export, Cold Spring Harbor Laboratory.
• Castelli LM, Sanchez-Martinez A, Lin Y-H, Upadhyay SK, Higginbottom A, Cooper-Knock J, Gül A, Walton A, Montmasson C, Cohen R , Bauer CS et al () A cell-penetrant peptide blocking C9ORF72-repeat RNA nuclear export suppresses neurodegeneration, Cold Spring Harbor Laboratory.
• Castelli LM, Cutillo L, Souza CDS, Sanchez-Martinez A, Granata I, Myszczynska MA, Heath PR, Livesey MR, Ning K, Azzouz M , Shaw PJ et al () Safety and efficacy of C9ORF72-repeat RNA nuclear export inhibition in amyotrophic lateral sclerosis, Cold Spring Harbor Laboratory.
• Cooper-Knock J, Moll T, Ramesh T, Castelli L, Beer A, Robins H, Fox I, Niedermoser I, Van Damme P, Robberecht W , Hardiman O et al () Mutations in the Glycosyltransferase Domain of GLT8D1 Cause Amyotrophic Lateral Sclerosis.