Dr Osman Shabir

BSc (Hons), MSc, PhD

Clinical Medicine, School of Medicine and Population Health

BHF Immediate Postdoctoral Fellow

Alzheimer's Research UK (ARUK) Yorkshire Network Coordinator

o.shabir@sheffield.ac.uk
+44 114 215 9524

B1-223a , Alfred Denny Building

Full contact details

Dr Osman Shabir
Clinical Medicine, School of Medicine and Population Health
B1-223a
Alfred Denny Building
Western Bank
Sheffield
S10 2TN

Profile

For enquiries please contact - SMPH-West-Operational@sheffield.ac.uk

BSc (Hons) Biomedical Science (2012-15)
MSc Translational Neuroscience (2015-16)
PhD Neurovascular Neuroscience (2017-20)
Postdoctoral Research Associate (2020-23)
BHF Research Fellow (2023-present)

I am a member of the Neuroscience Institute and the Healthy Lifespan Institute.

Research interests

I study neuroinflammation, neurovascular function (neurophysiology) in neurodegenerative and cerebrovascular diseases such as Alzheimer’s disease/vascular dementia & cardiovascular disease (atherosclerosis). I use preclinical models of human disease to study neurophysiology, neuropathology & neuroinflammation in these models to gain a better understanding of disease mechanisms and processes.

neurovascular function, heart disease — Neurovascular function; 'healthy' & 'heart disease.

To study neurovascular function, I use neuroimaging techniques including 2D-optical imaging spectroscopy, 2-photon microscopy, GCaMP fluorescence and microelectrode electrophysiology. In addition, I use standard cellular and molecular neuroscience techniques to validate in vivo observations.

In September 2023, I was awarded a 4-year British Heart Foundation (BHF) fellowship (basic science immediate). My fellowship aims to investigate the use of arthritis drugs (IL1 inhibitors) in preclinical models of atherosclerosis (vascular dementia) and Alzheimer’s disease with atherosclerosis.

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Shabir O, Moll TA, Matuszyk MM, Eyre B, Dake MD, Berwick J & Francis SE (2020) Preclinical models of disease and multimorbidity with focus upon cardiovascular disease and dementia. Mechanisms of Ageing and Development, 192, 111361-111361.
Shabir O, Sharp P, Rebollar MA, Boorman L, Howarth C, Wharton SB, Francis SE & Berwick J (2020) Enhanced cerebral blood volume under normobaric hyperoxia in the J20-hAPP mouse model of Alzheimer’s disease. Scientific Reports, 10(1). View this article in WRRO
Lee L, Boorman L, Glendenning E, Christmas C, Sharp P, Redgrave P, Shabir O, Bracci E, Berwick J & Howarth C (2020) Key Aspects of Neurovascular Control Mediated by Specific Populations of Inhibitory Cortical Interneurons. Cerebral Cortex, 30(4), 2452-2464. View this article in WRRO
Sharp P, Ameen-Ali K, Boorman L, Harris S, Wharton S, Howarth C, Shabir O, Redgrave P & Berwick J (2019) Neurovascular coupling preserved in a chronic mouse model of Alzheimer’s disease: Methodology is critical.. Journal of Cerebral Blood Flow and Metabolism. View this article in WRRO
Shabir O, Berwick J & Francis S (2018) Neurovascular Dysfunction in Vascular Dementia, Alzheimer’s and Atherosclerosis. BMC Neuroscience, 19. View this article in WRRO
Shelkovnikova TA, Kukharsky MS, An H, Dimasi P, Alexeeva S, Shabir O, Heath PR & Buchman VL (2018) Protective paraspeckle hyper-assembly downstream of TDP-43 loss of function in amyotrophic lateral sclerosis. Molecular Neurodegeneration, 13(1). View this article in WRRO

All publications

Journal articles

Boorman LW, Harris SS, Shabir O, Lee L, Eyre B, Howarth C & Berwick J (2023) Bidirectional alterations in brain temperature profoundly modulate spatiotemporal neurovascular responses in-vivo. Communications Biology, 6.
Eyre B, Shabir O, Lee L, Francis S, Howarth C & Berwick J (2022) How does alzheimer’s disease, atherosclerosis and comorbid alzheimer’s disease and atherosclerosis impact neurovascular function?. Alzheimer's & Dementia, 18(S6).
Shabir O, Moll TA, Matuszyk MM, Eyre B, Dake MD, Berwick J & Francis SE (2020) Preclinical models of disease and multimorbidity with focus upon cardiovascular disease and dementia. Mechanisms of Ageing and Development, 192, 111361-111361.
Shabir O, Sharp P, Rebollar MA, Boorman L, Howarth C, Wharton SB, Francis SE & Berwick J (2020) Enhanced cerebral blood volume under normobaric hyperoxia in the J20-hAPP mouse model of Alzheimer’s disease. Scientific Reports, 10(1). View this article in WRRO
Lee L, Boorman L, Glendenning E, Christmas C, Sharp P, Redgrave P, Shabir O, Bracci E, Berwick J & Howarth C (2020) Key Aspects of Neurovascular Control Mediated by Specific Populations of Inhibitory Cortical Interneurons. Cerebral Cortex, 30(4), 2452-2464. View this article in WRRO
Sharp P, Ameen-Ali K, Boorman L, Harris S, Wharton S, Howarth C, Shabir O, Redgrave P & Berwick J (2019) Neurovascular coupling preserved in a chronic mouse model of Alzheimer’s disease: Methodology is critical.. Journal of Cerebral Blood Flow and Metabolism. View this article in WRRO
Shabir O, Berwick J & Francis S (2018) Neurovascular Dysfunction in Vascular Dementia, Alzheimer’s and Atherosclerosis. BMC Neuroscience, 19. View this article in WRRO
Shelkovnikova TA, Kukharsky MS, An H, Dimasi P, Alexeeva S, Shabir O, Heath PR & Buchman VL (2018) Protective paraspeckle hyper-assembly downstream of TDP-43 loss of function in amyotrophic lateral sclerosis. Molecular Neurodegeneration, 13(1). View this article in WRRO
Shabir O () Mice modelling heart disease have poor brain blood flow regulation: prelude to dementia.. TheScienceBreaker, 8(3).
Eyre B, Shaw K, Sharp P, Boorman L, Lee L, Shabir O, Berwick J & Howarth C () The effects of locomotion on sensory-evoked haemodynamic responses in the cortex of awake mice. Scientific Reports.
Shabir O, Pendry B, Heath PR, Rebollar MA, Howarth C, Wharton SB, Berwick J & Francis SE () Neurovascular Function in a Novel Model of Experimental Atherosclerosis.
Shabir O, Pendry B, Lee L, Eyre B, Sharp P, Rebollar M, Drew D, Howarth C, Heath P, Wharton S , Francis S et al () Assessment of neurovascular coupling and cortical spreading depression in mixed mouse models of atherosclerosis and Alzheimer’s disease. eLife. View this article in WRRO
Shabir O, Pendry B, Lee L, Eyre B, Sharp P, Rebollar MA, Howarth C, Heath PR, Wharton SB, Francis SE & Berwick J () Assessment of Neurovascular Coupling & Cortical Spreading Depression in Mixed Models of Atherosclerosis & Alzheimer’s Disease.

Conference proceedings papers

Howarth C, Lee L, Shabir O & Berwick J (2022) Investigating the involvement of nitric oxide in neurovascular coupling. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Vol. 42(1_SUPPL) (pp 60-60)

Preprints

Eyre B, Shaw K, Drew D, Rayson A, Shabir O, Lee L, Francis S, Berwick J & Howarth C (2024) Characterizing vascular function in mouse models of Alzheimer’s disease, atherosclerosis, and mixed Alzheimer’s and atherosclerosis, Cold Spring Harbor Laboratory.
Boorman LW, Harris SS, Shabir O, Lee L, Eyre B, Howarth C & Berwick J () Bidirectional alterations in brain temperature profoundly modulate spatiotemporal neurovascular responses in-vivo: Implications for theragnostics, Cold Spring Harbor Laboratory.
Eyre B, Shaw K, Sharp P, Boorman L, Lee L, Shabir O, Berwick J & Howarth C () The effects of locomotion on sensory-evoked haemodynamic responses in the cortex of awake mice, Cold Spring Harbor Laboratory.
Shabir O, Sharp P, Rebollar MA, Boorman L, Howarth C, Wharton SB, Francis SE & Berwick J () Enhanced Cerebral Blood Volume under Normobaric Hyperoxia in the J20-hAPP Mouse Model of Alzheimer’s Disease.

Research group

PhD Students:

Tom Chittenden (2024-) as Primary Supervisor (Secondary: Dr Jason Berwick, Third: Prof Sheila Francis). Neuroscience Institute funded 3.5-year project: “Repurposing IL-1 Inhibitors for the Treatment of Vascular Dementia”.

MSc and SSC students:

Antonia Barton & Kian Zucconi, MBChB Phase 2A SSC (2024)
Aasritha Doppalapudi, MSc Translational Neuroscience (2023-24)
April Carne, MSc Translational Neuroscience (2022-23)
Sam Turner & Tom Coles, MBChB Phase 2A SSC (2022/24)
Olivia Slanley & Jasmine Waters, MBChB Phase 2A SSC (2021)
Paige Wolverson, MSc Translational Neuroscience (2020-21)
Ben Pendry, MSc Translational Neuropathology (2018-19)

I collaborate with:

Prof Sheila Francis, School of Medicine & Population Health
Dr Jason Berwick, Psychology
Prof Stuart Allan, University of Manchester
Dr Clare Howarth, Psychology
Dr Julie Simpson, SITraN
Dr Mark Dunning, School of Medicine & Population Health
Prof Kurt de Vos, SITraN
Dr Claudia Bauer, SITraN