Professor Endre Kiss-Toth
Clinical Medicine, School of Medicine and Population Health
School Director of Innovation
Professor of Cell Signalling
e.kiss-toth@sheffield.ac.uk
+44 114 215 9534
+44 114 215 9534
+44 114 271 1863
(Fax)
The Medical School
Full contact details
Professor Endre Kiss-Toth
Clinical Medicine, School of Medicine and Population Health
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Clinical Medicine, School of Medicine and Population Health
The Medical School
Beech Hill Road
Sheffield
S10 2RX
- Profile
-
For enquiries please contact - ClinMed-Operational@sheffield.ac.uk
I joined the University of Sheffield in 1988 as a postdoctoral researcher and was working on the development and implementation of a novel genetic screening approach.
This is based on detecting the bioactivity of proteins, which are transiently over expressed in mammalian cells. We used this approach to identify novel components of signalling pathways key in innate immunity. I have kept interest and association with this screening platform ever since and have recently been leading research identifying novel inflammatory regulators of macrophages.
In 2000, I was awarded a Career Development Fellowship by the Arthritis Research Campaign (now AR-UK) to characterise the mode of action of a novel family of proteins, tribbles.
In 2002, I joined the Cardiovascular Research Group as a Lecturer and developed my interest in tribbles further, by investigating their biological importance in vascular cells.
I became a Reader in 2013 and a Professor in 2017 with the same overall focus around regulation of innate immune signalling.
- Research interests
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My group is interested in identifying novel regulators of inflammatory signal transduction, characterising their basic mechanism of action, as well as validating some of these novel genes as potential drug targets for therapeutic intervention in chronic inflammatory diseases.
Much of our recent work has been focussing on studying the biological importance of the tribbles family of pseudokinases in cell types that are relevant to the development of cardiovascular disease.
We have established a global network of collaborators to pursue joint projects that aim to understand the importance of tribbles in cell biology, both in health and disease.
Current projects
- Discovery of novel regulators of inflammatory signalling.
- Defining the molecular mechanism of action for TMEM203, a novel inflammatory signalling regulator.
- Characterisation the biological importance of tribbles proteins in the development of lipid homeostasis, inflammation and metabolic syndromes
- Regulation of tribbles expression in vascular cells: development of novel anti-atherosclerotic drug targeting strategies.
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- A TNF Variant that Associates with Susceptibility to Musculoskeletal Disease Modulates Thyroid Hormone Receptor Binding to Control Promoter Activation. PLoS ONE, 8(9). View this article in WRRO
- The pseudokinase tribbles homologue-3 plays a crucial role in cannabinoid anticancer action.. Biochim Biophys Acta, 1831(10), 1573-1578.
- Identification of tribbles-1 as a novel binding partner of Foxp3 in regulatory T cells.. J Biol Chem, 288(14), 10051-10060.
- Identification of 34 novel proinflammatory proteins in a genome-wide macrophage functional screen.. PLoS One, 7(7), e42388. View this article in WRRO
- The tribbles gene family and lipoprotein metabolism.. Curr Opin Lipidol, 23(2), 122-126.
- Tribbles: 'puzzling' regulators of cell signalling.. Biochem Soc Trans, 39(2), 684-687.
- TILRR, a novel IL-1RI co-receptor, potentiates MyD88 recruitment to control Ras-dependent amplification of NF-kappa B (vol 285, pg 7222, 2010). J BIOL CHEM, 285(23), 18122-18122.
- Tribbles-1 and -2 are tumour suppressors, down-regulated in human acute myeloid leukaemia.. Immunol Lett, 130(1-2), 115-124.
- Individual susceptibility to periprosthetic osteolysis is associated with altered patterns of innate immune gene expression in response to pro-inflammatory stimuli.. J Orthop Res, 28(9), 1127-1135.
- Tribbles-2 is a novel regulator of inflammatory activation of monocytes.. Int Immunol, 20(12), 1543-1550. View this article in WRRO
- Human tribbles-1 controls proliferation and chemotaxis of smooth muscle cells via MAPK signaling pathways.. J Biol Chem, 282(25), 18379-18387. View this article in WRRO
- Tribbles: a family of kinase-like proteins with potent signalling regulatory function.. Cell Signal, 19(2), 238-250.
- Tribbles: novel regulators of cell function; evolutionary aspects.. Cell Mol Life Sci, 63(14), 1632-1641.
- Regulation of expression and signalling modulator function of mammalian tribbles is cell-type specific.. Immunol Lett, 104(1-2), 171-177.
- Functional mapping and identification of novel regulators for the Toll/Interleukin-1 signalling network by transcription expression cloning.. Cell Signal, 18(2), 202-214.
All publications
Journal articles
- Lipid-induced ATF4 signalling impairs macrophage efferocytosis and promotes atherosclerotic plaque necrosis. Atherosclerosis, 395, 118481-118481.
- Aging-related defects in macrophage function are driven by MYC and USF1 transcriptional programs. Cell Reports, 43(4), 114073-114073.
- The pseudokinase TRIB3 controls adipocyte lipid homeostasis and proliferation in vitro and in vivo. Molecular Metabolism, 78. View this article in WRRO
- Markers of the ageing macrophage: a systematic review and meta-analysis. Frontiers in Immunology, 14. View this article in WRRO
- The kinesin gene KIF26B modulates the severity of post-traumatic heterotopic ossification. International Journal of Molecular Sciences, 23(16).
- TRIB1 regulates tumor growth via controlling tumor-associated macrophage phenotypes and is associated with breast cancer survival and treatment response. Theranostics, 12(8), 3584-3600.
- Enhanced neutrophil extracellular trap formation in COVID-19 is inhibited by the PKC inhibitor ruboxistaurin. ERJ Open Research. View this article in WRRO
- Comprehensive profiling of mammalian Tribbles interactomes implicates TRIB3 in gene repression. Cancers, 13(24).
- Genomic and functional regulation of TRIB1 contributes to prostate cancer pathogenesis. Cancers, 12(9).
- A regenerative approach to canine osteoarthritis using allogeneic, adipose-derived mesenchymal stem cells. Safety results of a long-term follow-up. Frontiers in Veterinary Science, 7.
- Macrophage polarisation associated with atherosclerosis differentially affects their capacity to handle lipid. Atherosclerosis. View this article in WRRO
- Neutrophil microvesicles drive atherosclerosis by delivering miR-155 to atheroprone endothelium. Nature Communications, 11(1). View this article in WRRO
- Myeloid tribbles 1 induces early atherosclerosis via enhanced foam cell expansion. Science Advances, 5(10). View this article in WRRO
- TMEM203 is a binding partner and regulator of STING-mediated inflammatory signaling in macrophages. Proceedings of the National Academy of Sciences. View this article in WRRO
- Experimental models of murine atherosclerosis: does perception match reality?. Cardiovascular Research, 114(14), 1845-1847. View this article in WRRO
- The IL-1RI Co-Receptor TILRR (FREM1 Isoform 2) Controls Aberrant Inflammatory Responses and Development of Vascular Disease. JACC - Journal of the American College of Cardiology bts, 2(4), 398-414. View this article in WRRO
- Evidence for a role of TRIB3 in the regulation of megakaryocytopoiesis. Scientific Reports, 7. View this article in WRRO
- Regulating STING in health and disease. J Inflamm (Lond), 14, 11-11. View this article in WRRO
- TRIB2 confers resistance to anti-cancer therapy by activating the serine/threonine protein kinase AKT. Nature Communications, 8. View this article in WRRO
- Characterization and therapeutic application of canine adipose mesenchymal stem cells to treat elbow osteoarthritis. Canadian Journal of Veterinary Research, 8(1), 73-78. View this article in WRRO
- Differential IL-1β secretion by monocyte subsets is regulated by Hsp27 through modulating mRNA stability. Scientific Reports, 6. View this article in WRRO
- Competition between members of the tribbles pseudokinase protein family shapes their interactions with mitogen activated protein kinase pathways. Scientific Reports, 6. View this article in WRRO
- Multi-Compartmentalisation in the MAPK Signalling Pathway Contributes to the Emergence of Oscillatory Behaviour and to Ultrasensitivity. PLOS One, 11(5). View this article in WRRO
- Particle-Induced Osteolysis Is Mediated by TIRAP/Mal in Vitro and in Vivo. The Journal of Bone and Joint Surgery, 98(4), 285-294.
- Tribbles in inflammation. Biochemical Society Transactions, 43(5), 1069-1074. View this article in WRRO
- Tribbles at the cross-roads…. Biochemical Society Transactions, 43(5), 1049-1050.
- Tribbles role in reproduction. Biochemical Society Transactions, 43(5), 1116-1121.
- Oncosuppressive functions of tribbles pseudokinase 3. Biochemical Society Transactions, 43(5), 1122-1126.
- TRIB3 suppresses tumorigenesis by controlling mTORC2/AKT/FOXO signaling.. Molecular & Cellular Oncology, 2(3). View this article in WRRO
- Genetic variation in inflammatory and bone turnover pathways and risk of osteolytic responses to prosthetic materials. Journal of Orthopaedic Research, 33(2), 193-198. View this article in WRRO
- Loss of Tribbles pseudokinase-3 promotes Akt-driven tumorigenesis via FOXO inactivation. Cell Death & Differentiation, 22(1), 131-144. View this article in WRRO
- 213 Functional Characterisation of Monocyte Derived Macrophage Phenotypes for their Role in Atherosclerosis.. Heart, 100 Suppl 3, A117.
- A TNF Variant that Associates with Susceptibility to Musculoskeletal Disease Modulates Thyroid Hormone Receptor Binding to Control Promoter Activation. PLoS ONE, 8(9). View this article in WRRO
- Characterization of four novel beta 3 integrin defects associated with Glanzmann's thrombasthenia. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 11, 224-224.
- The pseudokinase tribbles homologue-3 plays a crucial role in cannabinoid anticancer action.. Biochim Biophys Acta, 1831(10), 1573-1578.
- Identification of tribbles-1 as a novel binding partner of Foxp3 in regulatory T cells.. J Biol Chem, 288(14), 10051-10060.
- Generation of a novel mouse model for the inducible depletion of macrophages in vivo.. Genesis, 51(1), 41-49.
- The Tribbles-1 protein in humans: roles and functions in health and disease.. Curr Mol Med, 13(1), 80-85.
- Enhanced macrophage tribbles-1 expression in murine experimental atherosclerosis.. Biology (Basel), 1(1), 43-57. View this article in WRRO
- Bioinformatics Analysis of the FREM1 Gene—Evolutionary Development of the IL-1R1 Co-Receptor, TILRR. Biology, 1(3), 484-494. View this article in WRRO
- Identification of 34 novel proinflammatory proteins in a genome-wide macrophage functional screen.. PLoS One, 7(7), e42388. View this article in WRRO
- Distinct control of MyD88 adapter-dependent and Akt kinase-regulated responses by the interleukin (IL)-1RI co-receptor, TILRR.. J Biol Chem, 287(15), 12348-12352.
- The tribbles gene family and lipoprotein metabolism.. Curr Opin Lipidol, 23(2), 122-126.
- Tribbles: 'puzzling' regulators of cell signalling.. Biochem Soc Trans, 39(2), 684-687.
- Age-related loss of CpG methylation in the tumour necrosis factor promoter. Cytokine, 56(3), 792-797. View this article in WRRO
- TILRR, a novel IL-1RI co-receptor, potentiates MyD88 recruitment to control Ras-dependent amplification of NF-kappa B (vol 285, pg 7222, 2010). J BIOL CHEM, 285(23), 18122-18122.
- Tribbles-1 and -2 are tumour suppressors, down-regulated in human acute myeloid leukaemia.. Immunol Lett, 130(1-2), 115-124.
- Individual susceptibility to periprosthetic osteolysis is associated with altered patterns of innate immune gene expression in response to pro-inflammatory stimuli.. J Orthop Res, 28(9), 1127-1135.
- TILRR, a novel IL-1RI co-receptor, potentiates MyD88 recruitment to control Ras-dependent amplification of NF-kappaB.. J Biol Chem, 285(10), 7222-7232.
- Reply to letter by Gallo and Petrek commenting on interleukin-1 receptor antagonist and interleukin-6 polymorphisms and post-total hip arthroplasty osteolysis.. Arthritis Rheum, 60(12), 3856-3857.
- Expression of tak1 and tram induces synergistic pro-inflammatory signalling and adjuvants DNA vaccines.. Vaccine, 27(41), 5589-5598.
- Tribbles-2 is a novel regulator of inflammatory activation of monocytes.. Int Immunol, 20(12), 1543-1550. View this article in WRRO
- Polymorphisms in the interleukin-1 receptor antagonist and interleukin-6 genes affect risk of osteolysis in patients with total hip arthroplasty.. Arthritis Rheum, 58(10), 3157-3165.
- LDL uptake by monocytes in response to inflammation is MAPK dependent but independent of tribbles protein expression.. Immunol Lett, 116(2), 178-183.
- Analysis of innate immune signal transduction with autocatalytic expression vectors.. J Immunol Methods, 330(1-2), 96-108.
- Advanced technologies for studies on protein interactomes.. Adv Biochem Eng Biotechnol, 110, 1-24.
- Human tribbles-1 controls proliferation and chemotaxis of smooth muscle cells via MAPK signaling pathways.. J Biol Chem, 282(25), 18379-18387. View this article in WRRO
- Tribbles: a family of kinase-like proteins with potent signalling regulatory function.. Cell Signal, 19(2), 238-250.
- Fluorescent protein reporter systems for single-cell measurements.. Methods Mol Biol, 411, 111-119.
- Feedback loops in intracellular signal processing and their potential for identifying novel signalling proteins.. Cell Immunol, 244(2), 158-161.
- Tribbles: novel regulators of cell function; evolutionary aspects.. Cell Mol Life Sci, 63(14), 1632-1641.
- Regulation of expression and signalling modulator function of mammalian tribbles is cell-type specific.. Immunol Lett, 104(1-2), 171-177.
- Functional mapping and identification of novel regulators for the Toll/Interleukin-1 signalling network by transcription expression cloning.. Cell Signal, 18(2), 202-214.
- Functional mapping of Toll/interleukin-1 signalling networks by expression cloning. Biochemical Society Transactions, 33(6), 1405-1405.
- Synergistic effect of Avemar on proinflammatory cytokine production and Ras-mediated cell activation.. Ann N Y Acad Sci, 1051, 515-528.
- Human tribbles, a protein family controlling mitogen-activated protein kinase cascades.. J Biol Chem, 279(41), 42703-42708.
- Hunting for genes by functional screens.. Cytokine Growth Factor Rev, 15(2-3), 97-102.
- Ultrasound-enhanced transgene expression in vascular cells is not dependent upon cavitation-induced free radicals.. Ultrasound Med Biol, 29(10), 1453-1461.
- A dilemma of functional genomics: Count the chickens or study their eggs?. Current Genomics, 3(3), 139-148.
- Rapid secretion of interleukin-1beta by microvesicle shedding.. Immunity, 15(5), 825-835.
- Ras controls tumor necrosis factor receptor-associated factor (TRAF)6-dependent induction of nuclear factor-kappa b. Selective regulation through receptor signaling components.. J Biol Chem, 276(9), 6280-6288.
- A method for enhancing the transfection efficiency of minipreps obtained from plasmid cDNA libraries.. Anal Biochem, 288(2), 230-232.
- Evidence for an accessory protein function for Toll-like receptor 1 in anti-bacterial responses.. J Immunol, 165(12), 7125-7132.
- A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling.. Proc Natl Acad Sci U S A, 97(18), 10162-10167.
- A novel mammalian expression screen exploiting green fluorescent protein-based transcription detection in single cells.. J Immunol Methods, 239(1-2), 125-135.
- Evidence for an accessory protein function for the Toll-like receptor TLR1 in lipopolysaccharide responses. FASEB J, 14(6), A1032-A1032.
- Characterization of the CD55 (DAF)-binding site on the seven-span transmembrane receptor CD97.. Eur J Immunol, 28(5), 1701-1707.
- Transcription factor AP-4 participates in activation of bovine leukemia virus long terminal repeat by p34 Tax.. Nucleic Acids Res, 22(23), 4872-4875.
- A downstream regulatory element activates the bovine leukemia virus promoter.. Biochem Biophys Res Commun, 202(3), 1553-1561.
- Member of the CREB/ATF protein family, but not CREB alpha plays an active role in BLV tax trans activation in vivo.. Nucleic Acids Res, 21(16), 3677-3682.
- Exploring the role of E. faecalis enterococcal polysaccharide antigen (
EPA ) and lipoproteins in evasion of phagocytosis. Molecular Microbiology.
- The potential therapeutic applications of long non-coding RNAs. Journal of Translational Genetics and Genomics, 8(2), 225-43.
- Tribbles1 is host protective during in vivo mycobacterial infection. eLife, 13.
- Tribbles Genes in Gastric Cancer: A Tumor-Suppressive Role for TRIB2. Genes, 15(1), 26-26.
- Development of a Large-Scale Pathogen Screening Test for the Biosafety Evaluation of Canine Mesenchymal Stem Cells. Biological Procedures Online, 25(1).
- Retraction Note: TRIB2 confers resistance to anti-cancer therapy by activating the serine/threonine protein kinase AKT. Nature Communications, 14(1).
- Tribbles 3 deficiency promotes atherosclerotic fibrous cap thickening and macrophage-mediated extracellular matrix remodelling. Frontiers in Cardiovascular Medicine, 9.
- Pathophysiology and Emerging Molecular Therapeutic Targets in Heterotopic Ossification. International Journal of Molecular Sciences, 23(13), 6983-6983.
- Tribbles-1 Expression and Its Function to Control Inflammatory Cytokines, Including Interleukin-8 Levels are Regulated by miRNAs in Macrophages and Prostate Cancer Cells. Frontiers in Immunology, 11.
- Genome-wide association and functional analyses identify CASC20 and KIF26B as target loci in heterotopic ossification.
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- TRIB1 regulates tumour growth via controlling tumour-associated macrophage phenotypes and is associated with breast cancer survival and treatment response.
Chapters
- T, Encyclopedia of Signaling Molecules (pp. 5299-5299). Springer International Publishing
Conference proceedings papers
- BS16 Neutrophil derived microvesicle migration across the endothelium to modulate the activity of macrophages within plaques. Basic science
- BS07 Micro RNA sequencing analysis of neutrophil derived microvesicles produced in response to proatherogenic stimuli. Basic science
- BS80 Macrophage ATP8B1 is upregulated with age. Basic Science
- BS45 Transcription factors MYC and USF1 drive chronic macrophage dysfunction in ageing. Basic Science
- BS1 Reprogramming human macrophages with drug X: potential mechanisms for stabilisation of atherosclerotic plaques. Heart, Vol. 107(Suppl 1) (pp a156-a156)
- Does myeloid expression of TRIB1 regulate plasma lipid levels?. Atherosclerosis, Vol. 241(1) (pp e34-e34)
- 223 MIRNA202 is a Novel Regulator of Tribbles-1 Expression. Heart, Vol. 101(Suppl 4) (pp A121.2-A121)
- 179 Investigation of human monocyte derived macrophage phenotypes for their functional role in atherosclerosis:. Heart, Vol. 101(Suppl 4) (pp A101.2-A102)
- 186 Assessment of Plaque Macrophage Phenotypein situby Multicolour Fluorescence Microscopy. Heart, Vol. 101(Suppl 4) (pp A104.2-A105)
- TRIBBLES-1 CONTRIBUTES TO MONOCYTE MIGRATION IN EXPERIMENTAL PERITONITIS. HEART, Vol. 99 (pp A126-A126)
- Tribbles-1 is expressed by regulatory T cells and interacts with FOXP3. IMMUNOLOGY, Vol. 137 (pp 418-418)
- Tribbles-1 Is Expressed by Regulatory T Cells and Interacts with Foxp3. AMERICAN JOURNAL OF TRANSPLANTATION, Vol. 12 (pp 445-445)
- Tribbles-1 Is Expressed by Regulatory T Cells and Interacts with FOXP3. AMERICAN JOURNAL OF TRANSPLANTATION, Vol. 10 (pp 363-363)
- THE ROLE OF TRIBBLES 2 IN PI3K CASCADE REGULATION AND AKT/PKB ANTI-APOPTOTIC SIGNALLING CASCADE. HEART, Vol. 95(22)
- Low-density lipoprotein controls IL-8 production in monocytes via tribbles-2. HEART, Vol. 94 (pp A44-A44)
- TRB proteins are competitive inhibitors of MAPK activation via interaction of MAPKKS. CYTOKINE, Vol. 39(1) (pp 13-13)
- Tribbles-1, a mitogen activated protein kinase (MAPK) scaffold regulates inflammation in vascular smooth muscle cells (VSMC) and atherosclerosis. HEART, Vol. 91 (pp A15-A15)
- A single nucleotide polymorphism at-238 in the TNF gene influences promoter activity in-vitro. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 17 (pp S237-S237)
- Detectability of prunus necrotic ringspot and plum pox viruses by RT-PCR, multiplex RT-PCR, ELISA and indexing on woody indicators. 17TH INTERNATIONAL SYMPOSIUM ON VIRUS AND VIRUS-LIKE DISEASES OF TEMPERATE FRUIT CROPS: FRUIT TREE DISEASES, VOLS 1 AND 2(472) (pp 243-247)
- Detection of plum pox virus by different methods. DIAGNOSIS AND IDENTIFICATION OF PLANT PATHOGENS, Vol. 11 (pp 317-319)
- REGULATION OF THE BOVINE LEUKEMIA-VIRUS BASAL TRANSCRIPTION. JOURNAL OF CELLULAR BIOCHEMISTRY (pp 48-48)
- THE INVIVO ROLE OF CREB-ALPHA ON HTLV-I AND BLV PROMOTERS. JOURNAL OF CELLULAR BIOCHEMISTRY (pp 24-24)
- PROTEIN AND DNA ELEMENTS INVOLVED IN THE TRANSCRIPTIONAL TRANSACTIVATION OF BLV. JOURNAL OF CELLULAR BIOCHEMISTRY (pp 131-131)
Preprints
- Exploring the role ofE. faecalisEnterococcal Polysaccharide Antigen (EPA) and lipoproteins in evasion of phagocytosis, Cold Spring Harbor Laboratory.
- Reprogramming Human Inflammatory Macrophages in Symptomatic Carotid Stenosis: Potential Mechanisms for Stabilisation of Atherosclerotic Carotid Plaques, Cold Spring Harbor Laboratory.
- Ageing-related defects in macrophage function are driven byMYCandUSF1transcriptional programmes, Cold Spring Harbor Laboratory.
- Tribbles1 and Cop1 cooperate to protect the host during in vivo mycobacterial infection, Cold Spring Harbor Laboratory.
- Enhanced neutrophil extracellular trap formation in COVID-19 is inhibited by the PKC inhibitor ruboxistaurin, Cold Spring Harbor Laboratory.
- Myeloid Tribbles 1 induces early atherosclerosis via enhanced foam cell expansion, Cold Spring Harbor Laboratory.
- Neutrophil microvesicles drive atherosclerosis by deliveringmiR-155to atheroprone endothelium.
- A TNF Variant that Associates with Susceptibility to Musculoskeletal Disease Modulates Thyroid Hormone Receptor Binding to Control Promoter Activation. PLoS ONE, 8(9). View this article in WRRO
- Research group
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- Kajus Baidzajevas
- Eva Hadadi
- Zabran Ilyas
- Jessica Johnston
- Li Yang
- Teaching interests
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I lecture on technologies and approaches designed to identify novel genes with a particular function. My other main area of teaching involves bioinformatics for molecular biology and functional genomics applications.