Professor Albert CM Ong

MA, DM, FRCP, FAoP, FERA

Clinical Medicine, School of Medicine and Population Health

Professor of Renal Medicine

Professor Albert Ong
Professor Albert Ong
Profile picture of Professor Albert Ong
a.ong@sheffield.ac.uk
+44 114 215 9542

Full contact details

Professor Albert CM Ong
Clinical Medicine, School of Medicine and Population Health
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Profile

For enquiries please contact - SMPH-West-Operational@sheffield.ac.uk

Albert Ong is Professor of Renal Medicine at the University of Sheffield, UK. He studied medicine at the University of Oxford and trained as a physician-scientist at University College London and Oxford. He held senior research fellowships from Kidney Research UK and the Wellcome Trust at Oxford and Sheffield. His scientific research focuses on the molecular basis of cyst formation, the biological basis for disease variability and drug discovery in autosomal dominant polycystic kidney disease (ADPKD). He founded and leads specialist services for ADPKD and other genetic kidney diseases at the Sheffield Kidney Institute. His work has been recognised through several national and international awards, including the ISN Lillian Jean Kaplan International Prize. As a key opinion leader, he continues to provide strategic advice and leadership internationally. He currently serves as Co-Director of the MRC-NIHR UK Renal Ciliopathies National Network (CILIAREN) and as a member of the ERA Council.

Research interests

My long-term research goals are to understand the molecular basis of cyst formation and the determinants of biological variation with the aim of developing novel therapies in ADPKD. Current areas of investigation are the role of cytoskeletal dysregulation in cyst initiation, changes in RNA metabolism in disease progression and the genetic basis of neonatal-onset PKD.


Projects:

  1. Role of compartmentalised GTPase signalling in polycystin regulation of actin structure and dynamics
  2. Non-coding RNAs as biomarkers of disease activity and as therapeutic targets
  3. RNA-binding proteins as key mediators of disease initiation and progression in ADPKD
  4. Complex genetics underlying very-early onset PKD
Publications

Show: Featured publications All publications

Journal articles

All publications

Journal articles

Chapters

Conference proceedings papers

  • Ong A, Valluru M, Streets A & Smith D (2024) A Polycystin-1-Bicaudal C1 complex regulates focal adhesion function through integrin beta-1, F-actin organisation and local translation in HKE cells. NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol. 39 (pp I219-I219) RIS download Bibtex download
  • Zagorec N, Calamel A, Ars E, Ong A, Halbritter J, Audrezet M-P, Pillay V-G, Le Meur Y, Sayer J & Cornec-Le Gall E (2024) Clinical spectrum and prognosis of the atypical polycystic kidney disease caused by monoallelic loss-of-function IFT140 variants. NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol. 39 (pp I213-I214) RIS download Bibtex download
  • Gittus M, Moore J & Ong A (2022) P73 Patients with polycystic liver disease have longer waiting times but better clinical outcomes following liver transplantation in the UK. Abstracts RIS download Bibtex download
  • Gittus M, Moore J & Ong A (2022) Patients with polcystic liver disease have longer waiting times but better clinical outcomes following liver transplantation in the UK. JOURNAL OF HEPATOLOGY, Vol. 77 (pp S814-S814) RIS download Bibtex download
  • Chen WCE, Ong A & Gittus M (2022) THE INTERACTION OF GENDER AND GENOTYPE IN THE DEVELOPMENT OF POLYCYSTIC LIVER DISEASE IN ADPKD. NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol. 37 (pp I7-I7) RIS download Bibtex download
  • Chung NKX, Valluru M, Butland L, Cook J, Dixit A & Ong A (2022) FAMILIAL CLUSTERING OF A RARE UMOD VARIANT IN UNDIAGNOSED HEREDITARY NEPHROPATHY SUGGESTS THE PRESENCE OF A COMMON ANCESTRAL FOUNDER MUTATION. NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol. 37 (pp I14-I15) RIS download Bibtex download
  • Winterbottom J, Simms R, Caroli A, Cornec-Le Gall E, Demoulin N, Furlano M, Meijer E, Devuyst O, Gansevoort R, LeMeur Y , Perico N et al (2021) FLANK PAIN HAS A MAJOR NEGATIVE IMPACT ON HEALTH-RELATED QUALITY OF LIFE IN ADPKD: THE CYSTIC I STUDY. NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol. 36 RIS download Bibtex download
  • Winterbottorn J, Simms R & Ong A (2020) REDUCED QUALITY OF LIFE IN ADPKD PATIENTS WITH CKD STAGE 1-3: THE CYSTIC I QUALITY OF LIFE STUDY. NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol. 35 (pp 98-98) RIS download Bibtex download
  • Magayr T, Streets A & Ong A (2020) SAT-442 Identification of exosome microRNAs as novel biomarkers for rapid disease progression in autosomal dominant polycystic kidney disease. Kidney International Reports, Vol. 5(3) (pp S185-S185). Abu Dhabi, United Arab Emirates, 26 March 2020 - 29 March 2020. View this article in WRRO RIS download Bibtex download
  • Vinh TH, Audrezet M-P, Domenger C, Bridoux F, Seret G, Longuet H, Halimi J-M, Senum S, Pajot A, Albaret J , Ponlot E et al (2019) CLINICAL PRESENTATION AND PROGNOSIS OF DNAJB11-ASSOCIATED NEPHROPATHY: AN INTERNATIONAL COLLABORATIVE STUDY. NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol. 34 RIS download Bibtex download
  • Magayr T, Streets A & Ong A (2019) GLOBAL MICRORNA PROFILING IN HUMAN URINARY EXOSOMES REVEALS NEW DISEASE BIOMARKERS AND CELLULAR PATHWAYS FOR AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE (ADPKD). NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol. 34 RIS download Bibtex download
  • Gimpel C, Avni EF, Breysem L, Burgmaier K, Caroli A, Cetiner M, Haffner D, Hartung EA, Franke D, König J , Liebau MC et al (2018) Imaging of kidney cysts and cystic kidney diseases in children. Consensus paper by an ad hoc committee. Ultraschall in der Medizin, 14 November 2018 - 16 November 2018. View this article in WRRO RIS download Bibtex download
  • Logeman C, Cho Y, Sautenet B, Rangan G, Gutman T, Craig J, Ong ACM, Chapman A, Ahn C, Coolican H , Kao JT-W et al (2018) PATIENT AND CAREGIVER BELIEFS, ATTITUDES AND PERSPECTIVES ON GENETIC SCREENING AND TESTING FOR AUTOSOMAL POLYCYSTIC KIDNEY DISEASE. NEPHROLOGY, Vol. 23 (pp 88-88) RIS download Bibtex download
  • Chong J, Durkie M, Dalton A & Ong A (2017) VERY EARLY-ONSET AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE DUE TO BI-ALLELIC MUTATIONS IN PKD1 AND PKD2. NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol. 32 (pp 94-94) RIS download Bibtex download
  • Simms RJ, Ryan D, Metherall P, Wright P, Gruel N, Tindale W & Ong ACM (2016) SO052DEVELOPMENT OF A RAPID SEMI-AUTOMATED TOOL TO MEASURE TOTAL KIDNEY VOLUME IN AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE. Nephrology Dialysis Transplantation, Vol. 31(suppl_1) (pp i22-i22) View this article in WRRO RIS download Bibtex download
  • Lannoy M, Abdela-ali F, Streets AJ & Ong ACM (2016) SELECTIVE PROSTAGLANDIN E2 RECEPTOR BLOCKADE FOR THE TREATMENT OF AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE. NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol. 31 (pp 22-23) RIS download Bibtex download
  • Rocío Cantero MD, Velázquez IF, Streets AJ, Ong ACM & Cantiello HF (2016) The Cyclic AMP Signaling Pathway and Direct PKA Phosphorylation Regulate Polycystin-2 (TRPP2) Channel Function. Biophysical Journal, Vol. 110(3) (pp 611a-612a) RIS download Bibtex download
  • Robinson P, McEwan P, Ong ACM, Ørskov B, Sandford R, Scolari F, Walz G, Bennet-Wilton H & O'Reilly K (2015) FP064ASSESSING THE LONG TERM OUTCOMES OF AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE (ADPKD) USING THE ADPKD OUTCOMES MODEL: A UK CASE STUDY. Nephrology Dialysis Transplantation, Vol. 30(suppl_3) (pp iii85-iii86) RIS download Bibtex download
  • Simms RJ, Thong KM, Dworschak GC & Ong ACM (2015) INCREASED PSYCHOSOCIAL BURDEN AND ADVERSE QUALITY OF LIFE IN AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE. NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol. 30 RIS download Bibtex download
  • Streets AJ, Xu Y & Ong ACM (2015) POLYCYSTIN-1 TRAFFICKING IS REGULATED BY CAMP DEPENDENT PHOSPHORYLATION OF THE PLAT DOMAIN. NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol. 30 RIS download Bibtex download
  • Robinson P, McEwan P, Hadimeri H, Ong ACM, Orskov B, Peces R, Sandford R, Scolari F, Walz G, Cooke C & O'Reilly K (2014) DEVELOPMENT OF A MODEL TO PREDICT DISEASE PROGRESSION IN AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE (ADPKD). NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol. 29 (pp 75-75) RIS download Bibtex download
  • Holden BJ, van Eeden FJ, Ong ACM & Chico TJ (2011) PKD2 MUTANT ZEBRAFISH DISPLAY EXCESSIVE DEVELOPMENTAL ANGIOGENESIS. HEART, Vol. 97(20) (pp 12-12) RIS download Bibtex download
  • Al-Marwani AO, Pearson D, Wagner B, Ong AC, Makris M & Daly ME (2009) Molecular genetic basis of inherited thrombocytopenia. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, Vol. 7 (pp 342-342) RIS download Bibtex download
  • Streets AJ, Ibraghimov-Beskrovnaya O & Ong ACM (2003) Regulation of polycystin-1 mediated intercellular adhesion by phosphorylation in renal epithelia cells. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, Vol. 14 (pp 575A-575A) RIS download Bibtex download
  • Robson L, Laycock SK, Brier T, Ong ACM & Haigh C (2003) A Ca2+-activated conductance in cultured mouse collecting duct cells.. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, Vol. 14 (pp 80A-80A) RIS download Bibtex download
  • Zhao Y, Haylor JL & Ong ACM (2002) Upregulation of polycystin-2 expression following experimental ischaemic renal injury.. J AM SOC NEPHROL, Vol. 13 (pp 113A-113A) RIS download Bibtex download

Preprints

Research group
  • Dr Andrew Streets
  • Dr Manoj Valluru
  • Dr Rebecca Walker
  • Dr Joshua Griffiths
  • Dr Matthew Gittus
  • Dr Zhu Zhou
  • Mr Patryk Zarecki
Teaching activities

I have had a long-standing commitment to postgraduate nephrology training especially to develop clinical and non-clinical academics in renal science and in enhancing nephrology training for young nephrologists for the developing ‘two-thirds’ world.

I served as Deputy Director for Clinical Academic Training at Sheffield (2020-2023), having previously served as Academic Programme Director for Nephrology. I was a member of the ISN Fellowship Committee (2019-2023), the Scientific Advisory Board of the ERA (2016-2022) and was a member of the UK Renal Association Executive committee as Chair of the International Committee (2009-2013).

Professional activities and memberships

National and International Committees

  • European Renal Association – Council member
  • European Renal Association - Scientific Program Chair 61st ERA Congress 2024
  • MRC-NIHR Renal Ciliopathies National Network – Co-Director
  • CYSTic Consortium – Chief investigator
  • ADPKD in Europe Consortium - Co-chair
  • European ADPKD Forum – Faculty member

Editorial Boards

  • Faculty of 1000 Medicine, Nephrology faculty
  • Theme Editor, Nephrology Dialysis Transplantation

Advisory Boards

  • Mayo Translational PKD Centre, Mayo Clinic, Rochester - External Faculty
  • Renal Genomic England Clinical Interpretation Partnership (GeCIP) – Co-chair for Cystic Diseases (2017-2023)
  • National Institute for Clinical Excellence (NICE) Technology Appraisal of Tolvaptan for ADPKD - Nominated Clinical Expert (2013-2015)

National and International Guidelines

  • UK Kidney Association Working Group for Tolvaptan in ADPKD – Chair
  • Kidney Diseases Improving Global Outcomes (KDIGO) ADPKD Guideline Initiative – Working group and Theme lead
  • Standardised Outcomes in Nephrology–PKD (SONG-PKD) – Steering committee