Academic clinical fellowships in haematology
Clinical and laboratory haematology at the Sheffield NHS Hospital Trust partners closely with the University of Sheffield School of Medicine and Population Health with several active academic programmes in haemato-oncology, haemostasis & thrombosis and laboratory haematology.
There are major interests in haematopoietic cell transplantation in both malignant and non-malignant diseases, which interface closely with other themes in the University of Sheffield, including cancer, neurosciences, infection and immunity and advanced therapies.
There is a productive environment for Academic Clinical Fellows (ACFs) and Clinical Lecturers (CLs) alongside the haematology specialist and academic training programmes to support clinical academics across all sub-specialities of Haematology. Haematology is a prime speciality for precision medicine and there are many opportunities in Sheffield for ground-breaking research and career development.
Research themes
Trainees can engage in a wide range of interdisciplinary research areas, alongside clinical training in all aspects of Haematology, including:
- Haematopoietic stem cell transplantation (HSCT) and CAR-T in cancer and non-malignant disorders.
- Myeloma, leukaemia, lymphoma, myeloproliferative neoplasms and other haematological cancers, from diagnostics, cell biology, molecular genetics, translational therapeutics, data science and clinical trials of HSCT, CAR-T and non-transplant treatments.
- Immunodeficiency, immune reconstitution, infection, vaccination in the immunocompromised haematology patient, especially following HSCT and cancer treatments.
- Supportive care, health related quality-of-life and survivorship research, focussing on physical and psychological aspects of prehabilitation and rehabilitation and late effects of cancer treatments, HSCT and CAR-T.
- Haemostasis and thrombosis, from molecular and data science to clinical trials.
- Transfusion medicine, in collaboration with NHSBT.
- The ability to accommodate interests in Paediatric Haematology in collaboration with colleagues in Sheffield Children’s Hospital.
Track record and impact
Trainees have been supported in securing higher degrees (MDs and PhDs), with some progressing to independent fellowships and clinical lectureships, building impactful research careers.
Our collaborative research has influenced British Society for Haematology (BSH) and international guidelines, as well as NICE and NHS Commissioning, and recognised in national awards, including NIHR and the Future NHS Parliamentary Awards. Our research has been presented at the annual meetings of BSH, EBMT, ASH, Haemostasis & Thrombosis and other professional and scientific societies.
Current developments
Professor Sergio Rutella leads a theme of translational research investigating the immune ecosystem of haematological cancers, including multi-omic and computational biology approaches in cancer-immune interactions to develop predictive biomarkers and guide treatment choices.
Dr Matthew Sims is investigating how the endogenous anticoagulant ‘Factor V short’ mediates thrombotic risk and how this rare isoform may be targetted in the treatment of thrombosis.
Staff
If you are interested in academic research into haematology at the University of Sheffield, as an academic clinical fellow or in other capacities, contact the academic lead:
