Dr Jing-Yi Jeng

Journal articles

• Underhill A, Webb S, Grandi FC, Carlton AJ, Jeng J, Johnson SL, Kros CJ & Marcotti W (2026) Myosin 7a is required for maintaining the transducing stereocilia and for force transmission to the MET channel during cochlear hair cell development. The Journal of Physiology. View this article in WRRO
• Amariutei AE, Webb S, Carlton AJ, O'Connor A, Underhill A, Jeng J, Hool SA, Zanella A, Hool M, Lecomte M , Johnson SL et al (2025) Adeno-associated virus-based rescue of Myo7a expression restores hair-cell function and improves hearing thresholds in a USH1B mouse strain. The Journal of Physiology, 603(22), 7171-7188. View this article in WRRO
• Ceriani F, Giles J, Ingham NJ, Jeng J-Y, Lewis MA, Steel KP, Arvaneh M & Marcotti W (2025) A machine-learning-based approach to predict early hallmarks of progressive hearing loss. Hearing Research, 464. View this article in WRRO
• Underhill A, Webb S, Grandi FC, Jeng J-Y, de Monvel JB, Plion B, Carlton AJ, Amariutei AE, Voulgari N, De Faveri F , Ceriani F et al (2025) MYO7A is required for the functional integrity of the mechanoelectrical transduction complex in hair cells of the adult cochlea. Proceedings of the National Academy of Sciences, 122(1). View this article in WRRO
• O’Connor AP, Amariutei AE, Zanella A, Hool SA, Carlton AJ, Kong F, Saenz-Roldan M, Jeng J-Y, Lecomte M-J, Johnson SL , Safieddine S et al (2024) In vivo AAV9-Myo7a gene rescue restores hearing and cholinergic efferent innervation in inner hair cells. JCI Insight, 9(23). View this article in WRRO
• Conrad LJ, Grandi FC, Carlton AJ, Jeng J, de Tomasi L, Zarecki P, Marcotti W, Johnson SL & Mustapha M (2024) The upregulation of K+ and HCN channels in developing spiral ganglion neurons is mediated by cochlear inner hair cells. The Journal of Physiology, 602(20), 5329-5351. View this article in WRRO
• Aguilar C, Williams D, Kurapati R, Bains RS, Mburu P, Parker A, Williams J, Concas D, Tateossian H, Haynes AR , Banks G et al (2024) Pleiotropic brain function of whirlin identified by a novel mutation. iScience, 27(7), 110170-110170.
• Carlton AJ, Jeng J-Y, Grandi FC, De Faveri F, Amariutei AE, De Tomasi L, O’Connor A, Johnson SL, Furness DN, Brown SDM , Ceriani F et al (2024) BAI1 localizes AMPA receptors at the cochlear afferent post-synaptic density and is essential for hearing. Cell Reports, 43(4). View this article in WRRO
• Hool SA, Jeng J, Jagger DJ, Marcotti W & Ceriani F (2023) Age‐related changes in P2Y receptor signalling in mouse cochlear supporting cells. The Journal of Physiology, 601(19), 4375-4395. View this article in WRRO
• Amariutei AE, Jeng J-Y, Safieddine S & Marcotti W (2023) Recent advances and future challenges in gene therapy for hearing loss. Royal Society Open Science, 10(6). View this article in WRRO
• Carlton AJ, Jeng J, Grandi FC, De Faveri F, Ceriani F, De Tomasi L, Underhill A, Johnson SL, Legan KP, Kros CJ , Richardson GP et al (2023) A critical period of prehearing spontaneous Ca2+ spiking is required for hair-bundle maintenance in inner hair cells. The EMBO Journal, 42(4). View this article in WRRO
• Jeng J-Y, Carlton AJ, Goodyear RJ, Chinowsky C, Ceriani F, Johnson SL, Sung T-C, Dayn Y, Richardson GP, Bowl MR , Brown SDM et al (2022) AAV-mediated rescue of Eps8 expression in vivo restores hair-cell function in a mouse model of recessive deafness. Molecular Therapy - Methods & Clinical Development, 26, 355-370. View this article in WRRO
• Murtha KE, Yang Y, Ceriani F, Jeng J-Y, Climer LK, Jones F, Charles J, Devana SK, Hornak AJ, Marcotti W & Simmons DD (2022) Oncomodulin (OCM) uniquely regulates calcium signaling in neonatal cochlear outer hair cells. Cell Calcium, 105, 102613-102613.
• Jeng J, Harasztosi C, Carlton AJ, Corns LF, Marchetta P, Johnson SL, Goodyear RJ, Legan KP, Rüttiger L, Richardson GP & Marcotti W (2021) MET currents and otoacoustic emissions from mice with a detached tectorial membrane indicate the extracellular matrix regulates Ca2+ near stereocilia. The Journal of Physiology, 599(7), 2015-2036. View this article in WRRO
• Carlton AJ, Halford J, Underhill A, Jeng J, Avenarius MR, Gilbert ML, Ceriani F, Ebisine K, Brown SDM, Bowl MR , Barr‐Gillespie PG et al (2021) Loss of Baiap2l2 destabilizes the transducing stereocilia of cochlear hair cells and leads to deafness. The Journal of Physiology, 599(4), 1173-1198. View this article in WRRO
• Jeng J, Carlton AJ, Johnson SL, Brown SDM, Holley MC, Bowl MR & Marcotti W (2021) Biophysical and morphological changes in inner hair cells and their efferent innervation in the ageing mouse cochlea. The Journal of Physiology, 599(1), 269-287. View this article in WRRO
• Jeng J, Ceriani F, Olt J, Brown SDM, Holley MC, Bowl MR, Johnson SL & Marcotti W (2020) Pathophysiological changes in inner hair cell ribbon synapses in the ageing mammalian cochlea. The Journal of Physiology, 598(19), 4339-4355. View this article in WRRO
• Jeng J, Johnson SL, Carlton AJ, DeTomasi L, Goodyear R, DeFaveri F, Furness DN, Wells S, Brown SDM, Holley MC , Richardson GP et al (2020) Age‐related changes in the biophysical and morphological characteristics of mouse cochlear outer hair cells. The Journal of Physiology, 598(18), 3891-3910. View this article in WRRO
• Jeng J, Ceriani F, Hendry A, Johnson SL, Yen P, Simmons DD, Kros CJ & Marcotti W (2020) Hair cell maturation is differentially regulated along the tonotopic axis of the mammalian cochlea. The Journal of Physiology, 598(1), 151-170. View this article in WRRO
• Bardhan T, Jeng J-Y, Waldmann M, Ceriani F, Johnson SL, Olt J, Rüttiger L, Marcotti W & Holley MC (2019) Gata3 is required for the functional maturation of inner hair cells and their innervation in the mouse cochlea.. Journal of Physiology, 597(13), 3389-3406. View this article in WRRO
• Ceriani F, Hendry A, Jeng JY, Johnson SL, Stephani F, Olt J, Holley MC, Mammano F, Engel J, Kros CJ , Simmons DD et al (2019) Coordinated calcium signalling in cochlear sensory and non‐sensory cells refines afferent innervation of outer hair cells. The EMBO Journal, 38(9). View this article in WRRO
• Ceriani F, Hendry A, Jeng J-Y, Johnson SL, Olt J, Holley MC, Mammano F, Kros CJ, Simmons DD & Marcotti W (2018) Spontaneous and coordinated Ca ²⁺ activity of cochlear sensory and non-sensory cells drives the maturation of OHC afferent innervation.
• Corns LF, Jeng J-Y, Richardson GP, Kros CJ & Marcotti W (2017) TMC2 Modifies Permeation Properties of the Mechanoelectrical Transducer Channel in Early Postnatal Mouse Cochlear Outer Hair Cells. Frontiers in Molecular Neuroscience , 10. View this article in WRRO

Preprints

• Yang Y, Jeng J-Y, Murtha K, Climer LK, Ceriani F, Sese WD, Hornak AJ, Sleiman KC, Stahl I, Charles Liberman M , Marcotti W et al (2024) Lack of Oncomodulin Increases ATP-Dependent Calcium Signaling and Susceptibility to Noise in Adult Mice, openRxiv.
• Murtha KE, Yang Y, Ceriani F, Jeng J-Y, Climer LK, Jones F, Charles J, Devana SK, Hornak AJ, Marcotti W & Simmons DD (2022) Oncomodulin (OCM) uniquely regulates calcium signaling in neonatal cochlear outer hair cells, openRxiv.