Professor Stuart Wilson

School of Biosciences

Roper Chair in Genetics

stuart.wilson@sheffield.ac.uk

Profile

2019- present: Roper Chair in Genetics
2008 - 2019: Professor, School of Biosciences, University of Sheffield
2008: Reader, Dept of Molecular Biology and Biotechnology, University of Sheffield
2003 - 2007: Senior Lecturer, Dept of Molecular Biology and Biotechnology, University of Sheffield
1999 - 2003: Lecturer Dept. of Biomolecular Sciences, UMIST
1996 - 1999: Weir Junior Research Fellow, University College Oxford
1995 - 1999: Wellcome Trust Career Development Fellow, Biochemistry Dept, Oxford University
1991 - 1995: Post-doctoral fellow, Biochemistry Department, University College London
1987 - 1991: PhD student, Biochemistry Department, University College London
1984 - 1987: Degree in Cell and Molecular Biology, Biophysics Department, King's College London

Research interests: My laboratory studies human gene expression and how defects in this process lead to various diseases including motor neuron disease and neurodevelopmental disorders. The group have a long-standing interest in how RNA binding proteins regulate gene expression with a particular interest in how mRNA is processed in the nucleus and subsequently transported to the cytoplasm. We use a wide range of technologies to study these processes including CRISPR engineering of human cells including stem cells, proteomics and next generation DNA sequencing methods to globally analyse gene expression at multiple levels including chromatin organisation, transcription and RNA processing. We also work closely with industrial partners to develop improved expression systems for biopharmaceuticals and most recently we have been developing strategies for improved therapeutic mRNAs. We are also working on a project to develop gene therapy approaches for the treatment of neurodevelopmental disorders such as hnRNPU syndrome. I am also the Director and Founder of the Sheffield Institute for Nucleic Acids (SInFoNiA) (https://sites.google.com/sheffield.ac.uk/sinfonia/home) which is the home for nucleic acids focussed research at the University of Sheffield.

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Viphakone N, Sudbery I, Griffith L, Heath CG, Sims D & Wilson SA (2019) Co-transcriptional Loading of RNA Export Factors Shapes the Human Transcriptome. Molecular Cell, 75(2), 310-323.e8.
Viphakone N, Hautbergue GM, Walsh M, Chang C-T, Holland A, Folco EG, Reed R & Wilson SA (2012) TREX exposes the RNA-binding domain of Nxf1 to enable mRNA export.. Nat Commun, 3, 1006.
Cruz-Migoni A, Hautbergue GM, Artymiuk PJ, Baker PJ, Bokori-Brown M, Chang C-T, Dickman MJ, Essex-Lopresti A, Harding SV, Mahadi NM , Marshall LE et al (2011) A Burkholderia pseudomallei toxin inhibits helicase activity of translation factor eIF4A.. Science, 334(6057), 821-824.
Dufu K, Livingstone MJ, Seebacher J, Gygi SP, Wilson SA & Reed R (2010) ATP is required for interactions between UAP56 and two conserved mRNA export proteins, Aly and CIP29, to assemble the TREX complex. Genes and Development, 24(18), 2043-2053.
Hung M-L, Hautbergue GM, Snijders APL, Dickman MJ & Wilson SA (2010) Arginine methylation of REF/ALY promotes efficient handover of mRNA to TAP/NXF1.. Nucleic Acids Res, 38(10), 3351-3361.
Hautbergue GM, Hung M-L, Walsh MJ, Snijders APL, Chang C-T, Jones R, Ponting CP, Dickman MJ & Wilson SA (2009) UIF, a New mRNA export adaptor that works together with REF/ALY, requires FACT for recruitment to mRNA.. Curr Biol, 19(22), 1918-1924.
Hautbergue GM, Hung M-L, Golovanov AP, Lian L-Y & Wilson SA (2008) Mutually exclusive interactions drive handover of mRNA from export adaptors to TAP.. Proc Natl Acad Sci U S A, 105(13), 5154-5159.

All publications

Journal articles

Riley JJ, Alexandru-Crivac CN, Bryce-Smith S, Wilson SA & Sudbery IM (2025) Widespread 3′ UTR splicing regulates expression of oncogene transcripts through multiple mechanisms. Nucleic Acids Research, 53(14), gkaf700. View this article in WRRO
Hodgson AKO, Baxandall L, Aiyedun D, Li A, Au PYB, Bain JM, Gillentine MA, Goel H, Kline AD, Ricupero CL , Sánchez‐Carpintero R et al (2025) Expanding the phenotypic spectrum of HNRNPU-related disorder, documenting the first familial presentation and comprehensive review. American Journal of Medical Genetics Part A, 197(6). View this article in WRRO
Siachisumo C, Luzzi S, Aldalaqan S, Hysenaj G, Dalgliesh C, Cheung K, Gazzara MR, Yonchev ID, James K, Kheirollahi Chadegani M , Ehrmann IE et al (2024) An anciently diverged family of RNA binding proteins maintain correct splicing of a class of ultra-long exons through cryptic splice site repression. eLife, 12. View this article in WRRO
Siachisumo C, Luzzi S, Aldalaqan S, Hysenaj G, Dalgliesh C, Cheung K, Gazzara MR, Yonchev ID, James K, Kheirollahi Chadegani M , Ehrmann IE et al (2024) An anciently diverged family of RNA binding proteins maintain correct splicing of a class of ultra-long exons through cryptic splice site repression. eLife, 12.
Baquero-Pérez B, Yonchev ID, Delgado-Tejedor A, Medina R, Puig-Torrents M, Sudbery I, Begik O, Wilson SA, Novoa EM & Díez J (2024) N6-methyladenosine modification is not a general trait of viral RNA genomes. Nature Communications, 15(1). View this article in WRRO
Koffa MD, Clements JB, Izaurralde E, Wadd S, Wilson SA, Mattaj IW & Kuersten S (2023) Herpes simplex virus ICP27 protein provides viral mRNAs with access to the cellular mRNA export pathway. The EMBO Journal, 42(14).
Manners O, Baquero-Perez B, Mottram TJ, Yonchev ID, Trevelyan CJ, Harper KL, Menezes S, Patterson MR, Macdonald A, Wilson SA , Aspden JL et al (2023) m6A regulates the stability of cellular transcripts required for efficient KSHV lytic replication. Viruses, 15(6). View this article in WRRO
Baquero-Perez B, Antanaviciute A, Yonchev ID, Carr IM, Wilson SA & Whitehouse A (2019) The tudor SND1 protein is an m6A RNA reader essential for replication of Kaposi’s sarcoma-associated herpesvirus. eLife, 8.
Viphakone N, Sudbery I, Griffith L, Heath CG, Sims D & Wilson SA (2019) Co-transcriptional Loading of RNA Export Factors Shapes the Human Transcriptome. Molecular Cell, 75(2), 310-323.e8.
Lesbirel S & Wilson SA (2019) The m6A‑methylase complex and mRNA export. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 1862(3), 319-328. View this article in WRRO
Lesbirel S, Viphakone N, Parker M, Parker J, Heath C, Sudbery I & Wilson SA (2018) The m6A-methylase complex recruits TREX and regulates mRNA export. Scientific Reports, 8(1). View this article in WRRO
Heath CG, Viphakone N & Wilson SA (2016) The role of TREX in gene expression and disease. Biochemical Journal, 473(19), 2911-2935. View this article in WRRO
Cumberbatch MGK, Viphakone N, Livingstone M, Heath PR, Dickman M, Catto JWF & Wilson SA (2015) 227 Luzp4 defines a new mRNA export pathway in cancer cells. European Urology Supplements, 14(2), e227-e227b.
Pang KH, Cumberbatch MG, Wilson SA & Catto JWF (2015) 527 N6-methyladenosine mRNA methylation in common human cancers: Identifying a potential role in androgen-resistance within prostate cancer. European Urology Supplements, 14(2), e527-e527a.
Snijders AP, Hautbergue GM, Bloom A, Williamson JC, Minshull TC, Phillips HL, Mihaylov SR, Gjerde DT, Hornby DP, Wilson SA , Hurd PJ et al (2015) Arginine methylation and citrullination of splicing factor proline- and glutamine-rich (SFPQ/PSF) regulates its association with mRNA. RNA, 21(3), 347-359. View this article in WRRO
Viphakone N, Cumberbatch MG, Livingstone MJ, Heath PR, Dickman MJ, Catto JW & Wilson SA (2015) Luzp4 defines a new mRNA export pathway in cancer cells. Nucleic Acids Research, 43(4), 2353-2366.
Caballero-Lima D, Hautbergue GM, Wilson SA & Sudbery PE (2014) In C andida albicans hyphae, Sec2p is physically associated with SEC2 mRNA on secretory vesicles. Molecular Microbiology, 94(4), 828-842. View this article in WRRO
Cooper-Knock J, Walsh MJ, Higginbottom A, Robin Highley J, Dickman MJ, Edbauer D, Ince PG, Wharton SB, Wilson SA, Kirby J , Hautbergue GM et al (2014) Sequestration of multiple RNA recognition motif-containing proteins by C9orf72 repeat expansions.. Brain, 137(Pt 7), 2040-2051.
Cooper-Knock J, Walsh M, Higginbottom A, Highley JR, Bury J, Dickman M, Rattray M, Heath P, Wyles M, Ince P , Wharton S et al (2014) GGGGCC Repeat Expansion of C9ORF72 Is Toxic Via Sequestration Of RNA Binding Proteins And Consequent Disruption Of RNA Splicing (S56.004). Neurology, 82(10_supplement).
Cooper-Knock J, Walsh M, Higginbottom A, Highley JR, Bury J, Dickman M, Rattray M, Heath P, Wyles M, Ince P , Wharton S et al (2014) GGGGCC Repeat Expansion of C9ORF72 Is Toxic Via Sequestration Of RNA Binding Proteins And Consequent Disruption Of RNA Splicing (1II-2.005). Neurology, 82(10_supplement).
Tunnicliffe RB, Hautbergue GM, Wilson SA, Kalra P & Golovanov AP (2014) Competitive and cooperative interactions mediate RNA transfer from herpesvirus saimiri ORF57 to the mammalian export adaptor ALYREF.. PLoS Pathog, 10(2), e1003907.
Teng I-F & Wilson SA (2013) Mapping interactions between mRNA export factors in living cells.. PLoS One, 8(6), e67676.
Chang C-T, Hautbergue GM, Walsh MJ, Viphakone N, van Dijk TB, Philipsen S & Wilson SA (2013) Chtop is a component of the dynamic TREX mRNA export complex.. EMBO J, 32(3), 473-486.
Viphakone N, Hautbergue GM, Walsh M, Chang C-T, Holland A, Folco EG, Reed R & Wilson SA (2012) TREX exposes the RNA-binding domain of Nxf1 to enable mRNA export.. Nat Commun, 3, 1006.
Hautbergue GM & Wilson SA (2012) BLF1, the first Burkholderia pseudomallei toxin, connects inhibition of host protein synthesis with melioidosis.. Biochem Soc Trans, 40(4), 842-845.
Knuckles P, Vogt MA, Lugert S, Milo M, Chong MMW, Hautbergue GM, Wilson SA, Littman DR & Taylor V (2012) Drosha regulates neurogenesis by controlling neurogenin 2 expression independent of microRNAs.. Nat Neurosci, 15(7), 962-969.
Phelan MM, Goult BT, Clayton JC, Hautbergue GM, Wilson SA & Lian L-Y (2012) The structure and selectivity of the SR protein SRSF2 RRM domain with RNA.. Nucleic Acids Res, 40(7), 3232-3244.
Cruz-Migoni A, Hautbergue GM, Artymiuk PJ, Baker PJ, Bokori-Brown M, Chang C-T, Dickman MJ, Essex-Lopresti A, Harding SV, Mahadi NM , Marshall LE et al (2011) A Burkholderia pseudomallei toxin inhibits helicase activity of translation factor eIF4A.. Science, 334(6057), 821-824.
Jackson BR, Boyne JR, Noerenberg M, Taylor A, Hautbergue GM, Walsh MJ, Wheat R, Blackbourn DJ, Wilson SA & Whitehouse A (2011) An interaction between KSHV ORF57 and UIF provides mRNA-adaptor redundancy in herpesvirus intronless mRNA export.. PLoS Pathog, 7(7), e1002138.
Van Hateren NJ, Das RM, Hautbergue GM, Borycki A-G, Placzek M & Wilson SA (2011) FatJ acts via the Hippo mediator Yap1 to restrict the size of neural progenitor cell pools.. Development, 138(10), 1893-1902.
Tunnicliffe RB, Hautbergue GM, Kalra P, Jackson BR, Whitehouse A, Wilson SA & Golovanov AP (2011) Structural basis for the recognition of cellular mRNA export factor REF by herpes viral proteins HSV-1 ICP27 and HVS ORF57.. PLoS Pathog, 7(1), e1001244.
Clayton JC, Phelan M, Goult BT, Hautbergue GM, Wilson SA & Lian L-Y (2011) The 1H, 13C and 15N backbone and side-chain assignment of the RRM domain of SC35, a regulator of pre-mRNA splicing.. Biomol NMR Assign, 5(1), 7-10.
Dufu K, Livingstone MJ, Seebacher J, Gygi SP, Wilson SA & Reed R (2010) ATP is required for interactions between UAP56 and two conserved mRNA export proteins, Aly and CIP29, to assemble the TREX complex. Genes and Development, 24(18), 2043-2053.
Hung M-L, Hautbergue GM, Snijders APL, Dickman MJ & Wilson SA (2010) Arginine methylation of REF/ALY promotes efficient handover of mRNA to TAP/NXF1.. Nucleic Acids Res, 38(10), 3351-3361.
Walsh MJ, Hautbergue GM & Wilson SA (2010) Structure and function of mRNA export adaptors.. Biochem Soc Trans, 38(Pt 1), 232-236.
Clayton JC, Phelan M, Goult BT, Hautbergue GM, Wilson SA & Lian L-Y (2010) The 1H, 13C and 15N backbone and side-chain assignment of the RRM domain of SC35, a regulator of pre-mRNA splicing. Biomolecular NMR Assignments, 1-4.
Lambeth LS, Van Hateren NJ, Wilson SA & Nair V (2010) A direct comparison of strategies for combinatorial RNA interference. BMC MOL BIOL, 11.
Snijders APL, Hung M-L, Wilson SA & Dickman MJ (2010) Analysis of arginine and lysine methylation utilizing peptide separations at neutral pH and electron transfer dissociation mass spectrometry.. J Am Soc Mass Spectrom, 21(1), 88-96.
Hautbergue GM, Hung M-L, Walsh MJ, Snijders APL, Chang C-T, Jones R, Ponting CP, Dickman MJ & Wilson SA (2009) UIF, a New mRNA export adaptor that works together with REF/ALY, requires FACT for recruitment to mRNA.. Curr Biol, 19(22), 1918-1924.
Wright D, Ferjentsik Z, Chong SW, Qiu XH, Jiang YJ, Malapert P, Pourquie O, Van Hateren N, Wilson SA, Franco C , Gerhardt H et al (2009) Cyclic Nrarp mRNA Expression Is Regulated by the Somitic Oscillator but Nrarp Protein Levels Do Not Oscillate. DEV DYNAM, 238(12), 3043-3055.
Hautbergue GM, Hung M-L, Golovanov AP, Lian L-Y & Wilson SA (2008) Mutually exclusive interactions drive handover of mRNA from export adaptors to TAP.. Proc Natl Acad Sci U S A, 105(13), 5154-5159.
Tang CW, Maya-Mendoza A, Martin C, Zeng K, Chen SB, Feret D, Wilson SA & Jackson DA (2008) The integrity of a lamin-B1-dependent nucleoskeleton is a fundamental determinant of RNA synthesis in human cells. J CELL SCI, 121(7), 1014-1024.
Shiau CE, Lwigale PY, Das RM, Wilson SA & Bronner-Fraser M (2008) Robo2-Slit1 dependent cell-cell interactions mediate assembly of the trigeminal ganglion. NAT NEUROSCI, 11(3), 269-276.
Tintaru AM, Hautbergue GM, Hounslow AM, Hung M-L, Lian L-Y, Craven CJ & Wilson SA (2007) Structural and functional analysis of RNA and TAP binding to SF2/ASF.. EMBO Rep, 8(8), 756-762.
Smith TG, Van Hateren N, Tickle C & Wilson SA (2007) The expression of Fat-1 cadherin during chick limb development. INT J DEV BIOL, 51(2), 173-176.
Tintaru AM, Hautbergue GM, Hounslow AM, Lian L-Y, Wilson SA & Craven CJ (2007) Assignment of 1H, 13C, and 15N resonances for SF2 RNA recognition motif 2.. J Biomol NMR, 38(2), 193.
Manning L, Ohyama K, Saeger B, Hatano O, Wilson SA, Logan M & Placzek M (2006) Regional morphogenesis in the hypothalamus: a BMP-Tbx2 pathway coordinates fate and proliferation through Shh downregulation.. Dev Cell, 11(6), 873-885.
Hargous Y, Hautbergue GM, Tintaru AM, Skrisovska L, Golovanov AP, Stevenin J, Lian L-Y, Wilson SA & Allain FH-T (2006) Molecular basis of RNA recognition and TAP binding by the SR proteins SRp20 and 9G8.. EMBO J, 25(21), 5126-5137.
Golovanov AP, Hautbergue GM, Tintaru AM, Lian L-Y & Wilson SA (2006) The solution structure of REF2-I reveals interdomain interactions and regions involved in binding mRNA export factors and RNA.. RNA, 12(11), 1933-1948.
Golovanov AP, Hautbergue GM, Wilson SA & Lian L-Y (2006) Assignment of 1H, 13C, and 15N resonances for the REF2-I mRNA export factor.. J Biomol NMR, 36 Suppl 1, 41.
Das RM, Van Hateren NJ, Howell GR, Farrell ER, Bangs FK, Porteous VC, Manning EM, McGrew MJ, Ohyama K, Sacco MA , Halley PA et al (2006) A robust system for RNA interference in the chicken using a modified microRNA operon.. Dev Biol, 294(2), 554-563.
Williams BJL, Boyne JR, Goodwin DJ, Roaden L, Hautbergue GM, Wilson SA & Whitehouse A (2005) The prototype gamma-2 herpesvirus nucleocytoplasmic shuttling protein, ORF 57, transports viral RNA through the cellular mRNA export pathway.. Biochem J, 387(Pt 2), 295-308.
Genome Sequencing Consortium IC (2005) Erratum: Corrigendum: Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution. Nature, 433(7027), 777-777.
Hubbard SJ, Grafham DV, Beattie KJ, Overton IM, McLaren SR, Croning MDR, Boardman PE, Bonfield JK, Burnside J, Davies RM , Farrell ER et al (2005) Transcriptome analysis for the chicken based on 19,626 finished cDNA sequences and 485,337 expressed sequence tags. GENOME RES, 15(1), 174-183.
Hillier LW, Miller W, Birney E, Warren W, Hardison RC, Ponting CP, Bork P, Burt DW, Groenen MAM, Delany ME , Dodgson JB et al (2004) Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution. NATURE, 432(7018), 695-716.
Wong GKS, Liu B, Wang J, Zhang Y, Yang X, Zhang ZJ, Meng QS, Zhou J, Li DW, Zhang JJ , Ni PX et al (2004) A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms. NATURE, 432(7018), 717-722.
Golovanov AP, Hautbergue GM, Wilson SA & Lian L-Y (2004) A simple method for improving protein solubility and long-term stability.. J Am Chem Soc, 126(29), 8933-8939.
Brown WRA, Hubbard SJ, Tickle C & Wilson SA (2003) The chicken as a model for large-scale analysis of vertebrate gene function. NAT REV GENET, 4(2), 87-98.
Boardman PE, Sanz-Ezquerro J, Overton IM, Burt DW, Bosch E, Fong WT, Tickle C, Brown WRA, Wilson SA & Hubbard SJ (2002) A comprehensive collection of chicken cDNAs.. Curr Biol, 12(22), 1965-1969.
Wilson HL, Wilson SA, Surprenant A & North RA (2002) Epithelial membrane proteins induce membrane blebbing and interact with the P2X7 receptor C terminus.. J Biol Chem, 277(37), 34017-34023.
Koffa MD, Clements JB, Izaurralde E, Wadd S, Wilson SA, Mattaj IW & Kuersten S (2001) Herpes simplex virus ICP27 protein provides viral mRNAs with access to the cellular mRNA export pathway. EMBO J, 20(20), 5769-5778.
Yoon S, Kingsman SM, Kingsman AJ, Wilson SA & Mitrophanous KA (2000) Characterization of the equine infectious anaemia virus S2 protein.. J Gen Virol, 81(Pt 9), 2189-2194.
O'Hara BP, Wilson SA, Lee AW, Roe SM, Siligardi G, Drew RE & Pearl LH (2000) Structural adaptation to selective pressure for altered ligand specificity in the Pseudomonas aeruginosa amide receptor, amiC.. Protein Eng, 13(2), 129-132.
Wilson SA, Sieiro-Vazquez C, Edwards NJ, Iourin O, Byles ED, Kotsopoulou E, Adamson CS, Kingsman SM, Kingsman AJ & Martin-Rendon E (1999) Cloning and characterization of hIF2, a human homologue of bacterial translation initiation factor 2, and its interaction with HIV-1 matrix.. Biochem J, 342 ( Pt 1)(Pt 1), 97-103.
WILSON SA, SIEIRO-VAZQUEZ C, EDWARDS NJ, IOURIN O, BYLES ED, KOTSOPOULOU E, ADAMSON CS, KINGSMAN SM, KINGSMAN AJ & MARTIN-RENDON E (1999) Cloning and characterization of hIF2, a human homologue of bacterial translation initiation factor 2, and its interaction with HIV-1 matrix. Biochemical Journal, 342(1), 97-103.
Wilson SA, Brown EC, Kingsman AJ & Kingsman SM (1998) TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I.. Nucleic Acids Res, 26(15), 3460-3467.
Chamberlain D, O'Hara BP, Wilson SA, Pearl LH & Perkins SJ (1997) Oligomerization of the amide sensor protein AmiC by X-ray and neutron scattering and molecular modeling. Biochemistry, 36(26), 8020-8029.
Martin‐Rendon E, Marfany G, Wilson S, Ferguson DJP, Kingsman SM & Kingsman AJ (1996) Structural determinants within the subunit protein of Ty1 virus‐like particles. Molecular Microbiology, 22(4), 667-679.
Wilson SA, Wachira SJM, Norman RA, Pearl LH & Drew RE (1996) Transcription antitermination regulation of the Pseudomonas aeruginosa amidase operon. EMBO Journal, 15(21), 5907-5916.
WILSON SA, WILLIAMS RJ, PEARL LH & DREW RE (1995) IDENTIFICATION OF 2 NEW GENES IN THE PSEUDOMONAS-AERUGINOSA AMIDASE OPERON, ENCODING AN ATPASE (AMIB) AND A PUTATIVE INTEGRAL MEMBRANE-PROTEIN (AMIS). J BIOL CHEM, 270(32), 18818-18824.
Wilson SA & Drew RE (1995) Transcriptional analysis of the amidase operon from Pseudomonas aeruginosa. Journal of Bacteriology, 177(11), 3052-3057.
Pearl L, O'Hara B, Drew R & Wilson S (1994) Crystal structure of AmiC: the controller of transcription antitermination in the amidase operon of Pseudomonas aeruginosa.. The EMBO Journal, 13(24), 5810-5817.
O'Hara BP, Wilson SA, Wyborn NW, Jones CW & Pearl LH (1994) Crystallisation, Preliminary X-Ray Analysis and Secondary Structure Detennination of Formamidase from Methyloplzilus methylotrophus. Protein & Peptide Letters, 1(3), 202-205.
Wilson SA, Wachira SJ, Drew RE, Jones D & Pearl LH (1993) Antitermination of amidase expression in Pseudomonas aeruginosa is controlled by a novel cytoplasmic amide-binding protein.. The EMBO Journal, 12(9), 3637-3642.
Wilson SA, Chayen NE, Hemmings AM, Drew RE & Pearl LH (1991) Crystallization of and preliminary X-ray data for the negative regulator (AmiC) of the amidase operon of Pseudomonas aeruginosa. Journal of Molecular Biology, 222(4), 869-871.
Wilson S & Drew R (1991) Cloning and DNA sequence of amiC, a new gene regulating expression of the Pseudomonas aeruginosa aliphatic amidase, and purification of the amiC product. Journal of Bacteriology, 173(16), 4914-4921.
Viphakone N, Hautbergue GM, Walsh M, Chang C-T, Holland A, Folco EG, Reed R & Wilson SA () Erratum: TREX exposes the RNA-binding domain of Nxf1 to enable mRNA export. Nature Communications, 4(1).

Book chapters

Wilson SA, Van Hateren NJ & jones RS (2009) RNA Interference in Chicken Embryos In Nakamura H (Ed.), Electroporation and Sonoporation in Developmental Biology (pp. 295-314). Springer Verlag
Wilson SA, van hateren NJ & das RM (2009) RNAi in chicken embryos In Doran DT & Helliwell C (Ed.), RNA interference: methods for plants and animals (pp. 183-204). CABI Publishing

Conference proceedings

Ohyama K, Wilson S, Briscoe J & Placzek M (2009) 13-P051 A temporal integration of BMP signalling controls progressive progenitor specification in the ventral diencephalon. Mechanisms of Development, Vol. 126 (pp S210-S210)

Preprints

Riley JJ, Alexandru-Crivac CN, Bryce-Smith S, Wilson SA & Sudbery IM (2024) Widespread 3’ UTR splicing regulates expression of oncogene transcripts in sequence-dependent and independent manners, Cold Spring Harbor Laboratory.
Baquero-Perez B, Yonchev ID, Delgado-Tejedor A, Medina R, Puig-Torrents M, Sudbery I, Begik O, Wilson SA, Maria Novoa E & Díez J (2023) N⁶-methyladenosine modification is not a general trait of viral RNA genomes, Cold Spring Harbor Laboratory.
Siachisumo C, Luzzi S, Aldalaqan S, Hysenaj G, Dalgliesh C, Cheung K, Gazzara MR, Yonchev ID, James K, Kheirollahi Chadegani M , Ehrmann I et al (2023) An anciently diverged family of RNA binding proteins maintain correct splicing of a class of ultra-long exons through cryptic splice site repression, Cold Spring Harbor Laboratory.
Manners O, Baquero-Perez B, Mottram TJ, Yonchev ID, Trevelyan CJ, Patterson MR, Macdonald A, Wilson SA, Aspden JL & Whitehouse A (2023) m⁶A regulates the stability of cellular transcripts required for efficient KSHV lytic replication, Cold Spring Harbor Laboratory.

Research group

Graduate students

Joshua Zilate (2020-2024) BBSRC CASE student with Astrazeneca – development of improved biopharmaceutical expression systems for CHO cells.

email: jzilate1@sheffield.ac.uk

Mikayla Fernholz (2021-2025) BBSRC CASE student with Astrazeneca – development of improved biopharmaceutical expression systems for CHO cells.

email: mfernholz1@sheffield.ac.uk

Ashleigh Whelan (2022-2026) BBSRC – Analysis of the role of RNA binding proteins in the DNA damage response.

email: agwhelan1@sheffield.ac.uk

Research staff

Dr Ang Li (2022-2025) BBSRC project on the role of RNA binding proteins in genome architecture and gene expression.

email: ali15@sheffield.ac.uk

Dr Chiara Galloni (2021-2025) MRC project on synthetic mRNA untranslated regions.

email: c.galloni@sheffield.ac.uk

Dr Charlotte Vandermeulen (2021-2025) MRC project on synthetic mRNA untranslated regions.

email: c.vandermeulen@sheffield.ac.uk

Dr Daniel Williams (2023-2024) Lifearc project on the development of gene therapy approaches for the treatment of hnRNPU syndrome.

email: Daniel.willaims@sheffield.ac.uk

Dr AN Other – new BBSRC funded post to be advertised shortly….

Laboratory Manager

Vicky Porteous-Medley

email: v.porteous@sheffield.ac.uk

Teaching activities

MBB325 The world of RNA (Module Coordinator)
MBB363 Genetics data handling
MBB361 Third year literature reviews
MBB380 Third year research projects
MBB402 Advanced literature review
MBB403/404 Advanced research projects

School of Biosciences

School of Biosciences

Professor Stuart Wilson

Featured publications

Journal articles

All publications

Journal articles

Book chapters

Conference proceedings

Preprints

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