Professor Sherif El-Khamisy

School of Biosciences

Professor of Molecular Medicine

Deputy Director of the Healthy Lifespan Institute

Chair in Molecular Medicine, Sherif El-Khamisy

S.El-Khamisy@sheffield.ac.uk
+44 114 222 2791

Firth Court

Full contact details

Professor Sherif El-Khamisy
School of Biosciences
Firth Court
Western Bank
Sheffield
S10 2TN

Profile

Career history

2015 - present: Director of Research and Innovation
2014 - present: Chair of Molecular Medicine, Krebs Institute, University of Sheffield
2014 - present: Wellcome Trust Investigator, Krebs Institute, University of Sheffield
2014 - present: Lister Research Fellow, Krebs Institute, University of Sheffield
2013 - 2015: Wellcome Trust Group Leader, Genome Center, University of Sussex
2013 - 2014: Reader, Krebs Institute, University of Sheffield
2008 - 2013: Wellcome Trust Fellow, Genome Center, University of Sussex
2007 - 2008: MRC Post-doctoral Fellow, Genome Center, University of Sussex, UK
2006: Post-doctoral Fellow, Dept. of Genetics, St Jude Children’s Research Hospital, USA
2005: Lecturer, Dept. of Biochemistry, Ain Shams University, Egypt
2002 - 2005: PhD in Biochemistry, University of Sussex, UK

Video animations summarising recent research discoveries

This video describes how DNA repair guards us against ALS, in particular the most common genetic cause for ALS and frontotemporal dementia caused by expansion in a gene called C9orf72. It summarises the work published in Nature Neuroscience on 17 July 2017.

How can the cells' powerhouse - mitochondria - protect their DNA? This video summarises a recent publication in Science Advances.

Major scientific accomplishments

Discovery of the mechanism of genomic instability and neural cell death in C9orf72 ALS (Nature Neuroscience 2017)
Discovery of protein-linked chromosomal break repair in the mitochondria (Science Advances 2017)
Discovery of a novel therapeutic strategy for ALS by inhibiting nuclear export (Nature communications 2017)
Elucidation of an epigenetic mechanism underlying irinotecan resistance in colorectal cancer (Nucleic Acids Research 2016)
Development of a nano-genomic technology to diagnose nucleic acid based infections (Biosensors 2016)
Discovery of the first human diseases resulting from accumulation of Top2-linked DNA breaks (Nature Genetics 2014)
Elucidation of the mechanisms underlying temozolomide therapy in brain tumors (Nucleic Acids Research 2014)
Development of techniques to measure protein-linked chromosomal breaks (Plos One 2013)
Identification of the molecular role of SUMOylation during single-strand break repair (Nature Communications 2012)
Identification of the role of XRCC1 during neural development and maintenance (Nature Neuroscience 2010)
Discovery of the enzyme that disjoins abortive topoisomerase 2 DNA breaks (Nature 2009)
Discovery of the function of the neuroprotective enzyme aprataxin (Nature 2006)
Identification of the first human disease with defects in chromosomal single-strand break repair (Nature 2005)
Elucidation of the role of CK2 in chromosomal single-strand break repair (Cell 2003)

Qualifications

Honours and distinctions

Wellcome Trust Investigator Award
Fellow of the Royal Society of Chemistry
Fellow of the Royal Society of Biology
Fellow of the Lister Institute of Preventative Medicine
Shoman Award for Medical Sciences
Sir Richard Stapley Award, UK
Lorne Duncan Award, UK

Research interests

The intertwined nature of the DNA double helix creates topological barriers that need to be resolved during all types of DNA transactions, in all forms of life from plant to man.

DNA topoisomerases achieve this by breaking and sealing the double helix, allowing the DNA to become untangled or unwound. During their normal catalytic cycle DNA topoisomerases become covalently attached to the DNA 3’-end (Top1) or to the 5’-end (Top2) via a reversible covalent phosphotyrosyl bond.

The presence of nearby oxidative DNA breaks (red circles) or collision with elongating RNA polymerases (RNA POL) during transcription results in ‘trapping’ of topoisomerases on DNA, causing protein-linked DNA breaks (PDBs), which are potent blocks to transcription and cell viability.

PDBs are repaired by a nucleolytic cleavage of DNA releasing the stalled Top and a fragment of DNA. Since this process results in an inevitable loss of genetic material, it is inherently error-prone.

Alternatively, PDBs can be repaired by an error-free mechanism in which the covalent phosphotyrosyl bond linking DNA to the stalled Top is cleaved by specific enzymes, such as tyrosyl DNA phosphodiesterases (TDP1 and TDP2). Interestingly, defects in TDPs cause neurological disease in man (see Fig.2).

In addition to maintaining genetic integrity in post-mitotic non cycling cells, accumulation of PDBs in cycling cells has been widely exploited to treat cancer (e.g. topoisomerase poisons such as Irinotecan and Topotecan), and therefore small molecule inhibitors of TDPs are emerging as attractive strategies to improve cancer therapy.

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Karyka E, Berrueta Ramirez N, Webster CP, Marchi PM, Graves EJ, Godena VK, Marrone L, Bhargava A, Ray S, Ning K , Crane H et al (2022) SMN-deficient cells exhibit increased ribosomal DNA damage. Life Science Alliance, 5(8), e202101145-e202101145.
Palminha NM, Dos Santos Souza C, Griffin J, Liao C, Ferraiuolo L & El-Khamisy SF (2022) Defective repair of topoisomerase I induced chromosomal damage in Huntington’s disease. Cellular and Molecular Life Sciences, 79(3). View this article in WRRO
Elserafy M, El-Shiekh I, Fleifel D, Atteya R, AlOkda A, Abdrabbou MM, Nasr M & El-Khamisy SF (2021) A role for Rad5 in ribonucleoside monophosphate (rNMP) tolerance. Life Science Alliance, 4(10), e202000966-e202000966.
Jurga M, Abugable AA, Goldman ASH & El-Khamisy SF (2021) USP11 controls R-loops by regulating senataxin proteostasis. Nature Communications, 12. View this article in WRRO
Ramachandran S, Ma TS, Griffin J, Ng N, Foskolou IP, Hwang M-S, Victori P, Cheng W-C, Buffa FM, Leszczynska KB , El-Khamisy SF et al (2021) Hypoxia-induced SETX links replication stress with the unfolded protein response. Nature Communications, 12(1). View this article in WRRO
Ashour ME, Allam W, Elsayed W, Atteya R, Elserafy M, Magdeldin S, Hassan MK & El-Khamisy SF (2021) High temperature drives topoisomerase mediated chromosomal break repair pathway choice. Cancers, 13(10). View this article in WRRO
Zaksauskaite R, Thomas RC, van Eeden F & El-Khamisy SF (2021) Tdp1 protects from topoisomerase 1–mediated chromosomal breaks in adult zebrafish but is dispensable during larval development. Science Advances, 7(5), eabc4165-eabc4165.
Kim HR, Santhakumar K, Markham E, Baldera D, Greenald D, Bryant HE, El-Khamisy SF & van Eeden FJ (2020) Investigation of the role of VHL-HIF signaling in DNA repair and apoptosis in zebrafish. Oncotarget, 11(13), 1109-1130. View this article in WRRO
Fielden J, Wiseman K, Torrecilla I, Li S, Hume S, Chiang S-C, Ruggiano A, Narayan Singh A, Freire R, Hassanieh S , Domingo E et al (2020) TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts. Nature Communications, 11(1). View this article in WRRO
Osman DI, El-Sheikh SM, Sheta SM, Ali OI, Salem AM, Shousha WG, EL-Khamisy SF & Shawky SM (2019) Nucleic acids biosensors based on metal-organic framework (MOF): Paving the way to clinical laboratory diagnosis. Biosensors and Bioelectronics, 141, 111451-111451.
Hegazy MT, Allam WR, Hussein MA, Zoheir N, Quartuccio L, El-Khamisy SF & Ragab G (2018) Increased genomic instability following treatment with direct acting anti-hepatitis C virus drugs. EBioMedicine, 35, 106-113. View this article in WRRO
Elserafy M, Abugable AA, Atteya R & El-Khamisy SF (2018) Rad5, HLTF, and SHPRH: A fresh view of an old story. Trends in Genetics, 34(8), 574-577. View this article in WRRO
Kassouf N, Kay CWM, Volkov A, Chiang S-C, Birch-Machin MA, El-Khamisy SF & Haywood RM (2018) UVA-induced carbon-centred radicals in lightly pigmented cells detected using ESR spectroscopy. Free Radical Biology and Medicine, 126, 153-165.
Mohamed Z, Hassan MK, Okasha S, Mitamura T, Keshk S, Konno Y, Kato T, EL-khamisy SF, Ohba Y & Watari H (2018) miR-363 confers taxane resistance in ovarian cancer by targeting the Hippo pathway member, LATS2. Oncotarget, 9(53), 30053-30065. View this article in WRRO
Liao C, Beveridge R, Hudson JJR, Parker JD, Chiang S-C, Ray S, Ashour ME, Sudbery I, Dickman MJ & El-Khamisy SF (2018) UCHL3 Regulates Topoisomerase-Induced Chromosomal Break Repair by Controlling TDP1 Proteostasis. Cell Reports, 23(11), 3352-3365. View this article in WRRO
Samir N, Matboli M, El-Tayeb H, El-Tawdi A, Hassan MK, Waly A, EL-Akkad HAE, Ramadan MG, Al-Belkini TN, El-Khamisy S & El-Asmar F (2018) Competing endogenous RNA network crosstalk reveals novel molecular markers in colorectal cancer. Journal of Cellular Biochemistry, 119(8), 6869-6881.
Walker C & El-Khamisy SF (2018) Perturbed autophagy and DNA repair converge to promote neurodegeneration in amyotrophic lateral sclerosis and dementia. Brain, 141(5), 1247-1262. View this article in WRRO
Elserafy M & El-Khamisy SF (2018) Choose your yeast strain carefully: the RAD5 gene matters. Nature Reviews Molecular Cell Biology, 19(6), 343-344.
Walker C, Herranz-Martin S, Karyka E, Liao C, Lewis K, Lukashchuk V, Chiang S-C, Ray S, Mulcahy PJ, Jurga M , Tsagakis I et al (2017) C9orf72 Expansion Disrupts ATM-mediated Chromosomal Break Repair. Nature Neuroscience, 20, 1225-1235. View this article in WRRO
Hautbergue GM, Castelli LM, Ferraiuolo L, Sanchez-Martinez A, Cooper-Knock J, Higginbottom A, Lin YH, Bauer CS, Dodd JE, myszczynska MA , Alam SM et al (2017) SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits. Nature Communications, 8. View this article in WRRO
Chiang S-C, Meagher M, Kassouf N, Hafezparast M, McKinnon PJ, Haywood R & El-Khamisy SF (2017) Mitochondrial protein-linked DNA breaks perturb mitochondrial gene transcription and trigger free radical–induced DNA damage. Science Advances, 3(4). View this article in WRRO
Meisenberg C, Ashour ME, El-Shafie L, Liao C, Hodgson A, Pilborough A, Khurram SA, Downs JA, Ward SE & El-Khamisy SF (2017) Epigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecan. Nucleic Acids Research, 45(3), 1159-1176. View this article in WRRO
Shawky SM, Awad AM, Allam W, Alkordi MH & EL-Khamisy SF (2016) Gold aggregating gold: A novel nanoparticle biosensor approach for the direct quantification of hepatitis C virus RNA in clinical samples. Biosensors and Bioelectronics. View this article in WRRO
Atteya R, Ashour ME, Ibrahim EE, Farag MA & El-Khamisy SF (2016) Chemical screening identifies the β-Carboline Alkaloid Harmine to be synergistically lethal with Doxorubicin. Mechanisms of Ageing and Development. View this article in WRRO
Elsayed W, El-Shafie L, Hassan MK, Farag MA & El-Khamisy SF (2016) Isoeugenol is a selective potentiator of camptothecin cytotoxicity in vertebrate cells lacking TDP1. Scientific Reports, 6, 26626-26626. View this article in WRRO
Mazouzi A, Stukalov A, Müller AC, Chen D, Wiedner M, Prochazkova J, Chiang S-C, Schuster M, Breitwieser FP, Pichlmair A , El-Khamisy SF et al (2016) A Comprehensive Analysis of the Dynamic Response to Aphidicolin-Mediated Replication Stress Uncovers Targets for ATM and ATMIN. Cell Reports, 15(4), 893-908. View this article in WRRO
Ashour ME, Atteya R & El-Khamisy SF (2015) Topoisomerase-mediated chromosomal break repair: an emerging player in many games. Nature Reviews Cancer, 15(3), 137-151.
Carroll J, Page TKW, Chiang S-C, Kalmar B, Bode D, Greensmith L, Mckinnon PJ, Thorpe JR, Hafezparast M & El-Khamisy SF (2015) Expression of a pathogenic mutation of SOD1 sensitizes aprataxin-deficient cells and mice to oxidative stress and triggers hallmarks of premature ageing. Human Molecular Genetics, 24(3), 828-840. View this article in WRRO
Meisenberg C, Gilbert DC, Chalmers A, Haley V, Gollins S, Ward SE & El-Khamisy SF (2015) Clinical and Cellular Roles for TDP1 and TOP1 in Modulating Colorectal Cancer Response to Irinotecan. Molecular Cancer Therapeutics, 14(2), 575-585.
Gómez-Herreros F, Schuurs-Hoeijmakers JHM, McCormack M, Greally MT, Rulten S, Romero-Granados R, Counihan TJ, Chaila E, Conroy J, Ennis S , Delanty N et al (2014) TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function. Nature Genetics, 46(5), 516-521.
Alagoz M, Wells OS & El-Khamisy SF (2014) TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy. Nucleic Acids Research, 42(5), 3089-3103. View this article in WRRO
Alagoz M, Chiang S-C, Sharma A & El-Khamisy SF (2013) ATM deficiency results in accumulation of DNA-topoisomerase I covalent intermediates in neural cells.. PLoS One, 8(4), e58239. View this article in WRRO
Zeng Z, Sharma A, Ju L, Murai J, Umans L, Vermeire L, Pommier Y, Takeda S, Huylebroeck D, Caldecott KW & El-Khamisy SF (2012) TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1.. Nucleic Acids Res, 40(17), 8371-8380. View this article in WRRO
Hudson JJR, Chiang S-C, Wells OS, Rookyard C & El-Khamisy SF (2012) SUMO modification of the neuroprotective protein TDP1 facilitates chromosomal single-strand break repair.. Nat Commun, 3, 733. View this article in WRRO
El-Khamisy SF (2011) To live or to die: a matter of processing damaged DNA termini in neurons.. EMBO Mol Med, 3(2), 78-88. View this article in WRRO
Zeng Z, Cortés-Ledesma F, El Khamisy SF & Caldecott KW (2011) TDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damage.. J Biol Chem, 286(1), 403-409.
Kerzendorfer C, Whibley A, Carpenter G, Outwin E, Chiang S-C, Turner G, Schwartz C, El-Khamisy S, Raymond FL & O'Driscoll M (2010) Mutations in Cullin 4B result in a human syndrome associated with increased camptothecin-induced topoisomerase I-dependent DNA breaks.. Hum Mol Genet, 19(7), 1324-1334.
Cortes Ledesma F, El Khamisy SF, Zuma MC, Osborn K & Caldecott KW (2009) A human 5'-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage.. Nature, 461(7264), 674-678.
Lee Y, Katyal S, Li Y, El-Khamisy SF, Russell HR, Caldecott KW & McKinnon PJ (2009) The genesis of cerebellar interneurons and the prevention of neural DNA damage require XRCC1.. Nat Neurosci, 12(8), 973-980. View this article in WRRO
Katyal S, el-Khamisy SF, Russell HR, Li Y, Ju L, Caldecott KW & McKinnon PJ (2007) TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo.. EMBO J, 26(22), 4720-4731.
Ahel I, Rass U, El-Khamisy SF, Katyal S, Clements PM, McKinnon PJ, Caldecott KW & West SC (2006) The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates.. Nature, 443(7112), 713-716.
El-Khamisy SF, Saifi GM, Weinfeld M, Johansson F, Helleday T, Lupski JR & Caldecott KW (2005) Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1. NATURE, 434(7029), 108-113.
Loizou JI, El-Khamisy SF, Zlatanou A, Moore DJ, Chan DW, Qin J, Sarno S, Meggio F, Pinna LA & Caldecott KW (2004) The protein kinase CK2 facilitates repair of chromosomal DNA single-strand breaks.. Cell, 117(1), 17-28.
El-Khamisy SF, Masutani M, Suzuki H & Caldecott KW (2003) A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage.. Nucleic Acids Res, 31(19), 5526-5533.

All publications

Journal articles

Alaswad Z, Attallah NE, Aboalazm B, Elmeslhy ES, Mekawy AS, Afify FA, Mahrous HK, Abdalla A, Rahmoon MA, Mohamed AA , Shata AH et al (2024) Insights into the human cDNA: A descriptive study using library screening in yeast. Journal of Genetic Engineering and Biotechnology, 22(4), 100427-100427.
Edwards H, Morton J, Moseley J, Marshall T, Berry A, Igwesi-Chidobe C, El-Khamisy S, Jones H & Farrow M (2024) 540P Assessing the effect of chronic nitrate supplementation on muscle mass and physical function outcomes. Neuromuscular Disorders, 43, 104441.131-104441.131.
Stevenson LK, Page AJ, Dowson M, ElBadry SK, Barnieh FM, Falconer RA & El-Khamisy SF (2024) The DNA repair kinase ATM regulates CD13 expression and cell migration. Frontiers in Cell and Developmental Biology, 12. View this article in WRRO
Abugable AA, Antar S & El-Khamisy SF (2024) Chromosomal single-strand break repair and neurological disease: implications on transcription and emerging genomic tools. DNA Repair, 103629-103629.
Rahmoon MA, Elghaish RA, Ibrahim AA, Alaswad Z, Gad MZ, El-Khamisy SF & Elserafy M (2024) Abstract A023: High glucose increases DNA damage and elevates the expression of multiple DDR genes. Cancer Research, 84(1_Supplement), A023-A023.
Barnieh FM, Galuska SP, Loadman PM, Ward S, Falconer RA & El-Khamisy SF (2023) Cancer-specific glycosylation of CD13 impacts its detection and activity in preclinical cancer tissues. iScience, 26(11), 108219-108219.
Edwards H, Jones H, Moseley J, Marshall T, El-Khamisy SF, Aung MN & Farrow M (2023) Nutritional Supplementation for the Prevention of Muscle Atrophy in Older People. Nutrition Today, 58(3), 105-118.
El-Khamisy SF (2023) Oxidative DNA damage and repair at non-coding regulatory regions. Trends in Cell Biology.
Rahmoon MA, Elghaish RA, Ibrahim AA, Alaswad Z, Gad MZ, El-Khamisy SF & Elserafy M (2023) High glucose increases DNA damage and elevates the expression of multiple DDR genes. Genes, 14(1).
Elghzaly AA, Sun C, Looger LL, Hirose M, Salama M, Khalil NM, Behiry ME, Hegazy MT, Hussein MA, Salem MN , Eltoraby E et al (2022) Genome-wide association study for systemic lupus erythematosus in an egyptian population. Frontiers in Genetics, 13.
Ray S, Abugable AA, Parker J, Liversidge K, Palminha NM, Liao C, Acosta-Martin AE, Souza CDS, Jurga M, Sudbery I & El-Khamisy SF (2022) A mechanism for oxidative damage repair at gene regulatory elements. Nature, 609(7929), 1038-1047.
Chaturvedi S, Naseem Z, El-Khamisy SF & Wahajuddin M (2022) Nanomedicines targeting the Inflammasome as a promising therapeutic approach for cell senescence. Seminars in Cancer Biology.
Al Saeedy D, Abuhijjleh RK, Gouda A, El-Khamisy SF & Al-Abd AM (2022) Abstract 1049: Modulating the polymorphic UGT1A1 gene to enhance camptothecin anti-colorectal effect. Cancer Research, 82(12_Supplement), 1049-1049.
Fuchs J, Schwer B & El-Khamisy SF (2022) Editorial: Genomic instability and neurodegeneration. Frontiers in Aging Neuroscience, 14.
Karyka E, Berrueta Ramirez N, Webster CP, Marchi PM, Graves EJ, Godena VK, Marrone L, Bhargava A, Ray S, Ning K , Crane H et al (2022) SMN-deficient cells exhibit increased ribosomal DNA damage. Life Science Alliance, 5(8), e202101145-e202101145.
Palminha NM, Dos Santos Souza C, Griffin J, Liao C, Ferraiuolo L & El-Khamisy SF (2022) Defective repair of topoisomerase I induced chromosomal damage in Huntington’s disease. Cellular and Molecular Life Sciences, 79(3). View this article in WRRO
Matboli M, Hassan MK, Ali MA, Mansour MT, Elsayed W, Atteya R, Aly HS, Meteini ME, Elghazaly H, El-Khamisy S & Agwa SHA (2022) Impact of circ-0000221 in the pathogenesis of hepatocellular via modulation of miR-661–PTPN11 mRNA axis. Pharmaceutics, 14(1).
Elserafy M, El-Shiekh I, Fleifel D, Atteya R, AlOkda A, Abdrabbou MM, Nasr M & El-Khamisy SF (2021) A role for Rad5 in ribonucleoside monophosphate (rNMP) tolerance. Life Science Alliance, 4(10), e202000966-e202000966.
Jurga M, Abugable AA, Goldman ASH & El-Khamisy SF (2021) USP11 controls R-loops by regulating senataxin proteostasis. Nature Communications, 12. View this article in WRRO
Chaudhari S, Ware AP, Jayaram P, Gorthi SP, El-Khamisy SF & Satyamoorthy K (2021) Apurinic/Apyrimidinic Endonuclease 2 (APE2): An ancillary enzyme for contextual base excision repair mechanisms to preserve genome stability. Biochimie, 190, 70-90.
Crane H, Foran B, Tahir F, Joyce H, El-Khamisy S & Hunter K (2021) CISPLATIN RESISTANCE IN HPV-POSITIVE AND HPV-NEGATIVE OROPHARYNGEAL SQUAMOUS CELL CARCINOMA. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 132(1), e15-e15.
Ramachandran S, Ma TS, Griffin J, Ng N, Foskolou IP, Hwang M-S, Victori P, Cheng W-C, Buffa FM, Leszczynska KB , El-Khamisy SF et al (2021) Hypoxia-induced SETX links replication stress with the unfolded protein response. Nature Communications, 12(1). View this article in WRRO
Boughey H, Jurga M & El-Khamisy SF (2021) Dna homeostasis and senescence: lessons from the naked mole rat. International Journal of Molecular Sciences, 22(11).
Ashour ME, Allam W, Elsayed W, Atteya R, Elserafy M, Magdeldin S, Hassan MK & El-Khamisy SF (2021) High temperature drives topoisomerase mediated chromosomal break repair pathway choice. Cancers, 13(10). View this article in WRRO
Hassan MK, Waly AA, Elsayed W, Keshk S, Allam WR & El-khamisy SF (2021) Integrative microRNA and gene expression analysis identifies new epigenetically regulated microRNAs mediating taxane resistance in ovarian cancer. Scientific Reports, 11(1).
Zaksauskaite R, Thomas RC, van Eeden F & El-Khamisy SF (2021) Tdp1 protects from topoisomerase 1–mediated chromosomal breaks in adult zebrafish but is dispensable during larval development. Science Advances, 7(5), eabc4165-eabc4165.
Halliwell JA, Frith TJR, Laing O, Price CJ, Bower OJ, Stavish D, Gokhale PJ, Hewitt Z, El-Khamisy SF, Barbaric I & Andrews PW (2020) Nucleosides rescue replication-mediated genome instability of human pluripotent stem cells. Stem Cell Reports, 14(6), 1009-1017. View this article in WRRO
Kim HR, Santhakumar K, Markham E, Baldera D, Greenald D, Bryant HE, El-Khamisy SF & van Eeden FJ (2020) Investigation of the role of VHL-HIF signaling in DNA repair and apoptosis in zebrafish. Oncotarget, 11(13), 1109-1130. View this article in WRRO
Fielden J, Wiseman K, Torrecilla I, Li S, Hume S, Chiang S-C, Ruggiano A, Narayan Singh A, Freire R, Hassanieh S , Domingo E et al (2020) TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts. Nature Communications, 11(1). View this article in WRRO
Ibler AEM, ElGhazaly M, Naylor KL, Bulgakova NA, F. El-Khamisy S & Humphreys D (2019) Typhoid toxin exhausts the RPA response to DNA replication stress driving senescence and Salmonella infection. Nature Communications, 10(1). View this article in WRRO
Osman DI, El-Sheikh SM, Sheta SM, Ali OI, Salem AM, Shousha WG, EL-Khamisy SF & Shawky SM (2019) Nucleic acids biosensors based on metal-organic framework (MOF): Paving the way to clinical laboratory diagnosis. Biosensors and Bioelectronics, 141, 111451-111451.
Abugable AA, Morris JLM, Palminha NM, Zaksauskaite R, Ray S & El-Khamisy SF (2019) DNA repair and neurological disease: From molecular understanding to the development of diagnostics and model organisms. DNA Repair, 81, 102669-102669.
Ghoneimy M, Nabil E, Badr A & El-Khamisy SF (2019) A new filter-based Gene selection method based on dragonfly optimization and correlation-based feature selection. BIOSCIENCE RESEARCH, 16(3), 3139-3154.
Moradzadeh M, Ghorbani A, Erfanian S, Mohaddes ST, Rahimi H, karimiani EG, Mashkani B, Chiang S, El‐Khamisy SF, Tabarraei A & Sadeghnia HR (2019) Study of the mechanisms of crocetin‐induced differentiation and apoptosis in human acute promyelocytic leukemia cells. Journal of Cellular Biochemistry, 120(2), 1943-1957.
Fleifel D, Rahmoon MA, AlOkda A, Nasr M, Elserafy M & El-Khamisy SF (2018) Recent advances in stem cells therapy: A focus on cancer, Parkinson’s and Alzheimer’s. Journal of Genetic Engineering and Biotechnology, 16(2), 427-432. View this article in WRRO
Shawky SM, Awad AM, Abugable AA & El-Khamisy SF (2018) Gold nanoparticles - an optical biosensor for RNA quantification for cancer and neurologic disorders diagnosis. International Journal of Nanomedicine, 13, 8137-8151. View this article in WRRO
Hegazy MT, Allam WR, Hussein MA, Zoheir N, Quartuccio L, El-Khamisy SF & Ragab G (2018) Increased genomic instability following treatment with direct acting anti-hepatitis C virus drugs. EBioMedicine, 35, 106-113. View this article in WRRO
Southam HM, Smith TW, Lyon RL, Liao C, Trevitt CR, Middlemiss LA, Cox FL, Chapman JA, El-Khamisy SF, Hippler M , Williamson MP et al (2018) A thiol-reactive Ru(II) ion, not CO release, underlies the potent antimicrobial and cytotoxic properties of CO-releasing molecule-3. Redox Biology, 18, 114-123. View this article in WRRO
Elserafy M, Abugable AA, Atteya R & El-Khamisy SF (2018) Rad5, HLTF, and SHPRH: A fresh view of an old story. Trends in Genetics, 34(8), 574-577. View this article in WRRO
Kassouf N, Kay CWM, Volkov A, Chiang S-C, Birch-Machin MA, El-Khamisy SF & Haywood RM (2018) UVA-induced carbon-centred radicals in lightly pigmented cells detected using ESR spectroscopy. Free Radical Biology and Medicine, 126, 153-165.
Mohamed Z, Hassan MK, Okasha S, Mitamura T, Keshk S, Konno Y, Kato T, EL-khamisy SF, Ohba Y & Watari H (2018) miR-363 confers taxane resistance in ovarian cancer by targeting the Hippo pathway member, LATS2. Oncotarget, 9(53), 30053-30065. View this article in WRRO
Liao C, Beveridge R, Hudson JJR, Parker JD, Chiang S-C, Ray S, Ashour ME, Sudbery I, Dickman MJ & El-Khamisy SF (2018) UCHL3 Regulates Topoisomerase-Induced Chromosomal Break Repair by Controlling TDP1 Proteostasis. Cell Reports, 23(11), 3352-3365. View this article in WRRO
Samir N, Matboli M, El-Tayeb H, El-Tawdi A, Hassan MK, Waly A, EL-Akkad HAE, Ramadan MG, Al-Belkini TN, El-Khamisy S & El-Asmar F (2018) Competing endogenous RNA network crosstalk reveals novel molecular markers in colorectal cancer. Journal of Cellular Biochemistry, 119(8), 6869-6881.
Walker C & El-Khamisy SF (2018) Perturbed autophagy and DNA repair converge to promote neurodegeneration in amyotrophic lateral sclerosis and dementia. Brain, 141(5), 1247-1262. View this article in WRRO
Elserafy M & El-Khamisy SF (2018) Choose your yeast strain carefully: the RAD5 gene matters. Nature Reviews Molecular Cell Biology, 19(6), 343-344.
Chiang S-C, Liversidge K & El-Khamisy SF (2018) Studying TDP1 Function in DNA Repair, 173-181.
Lissek T, Adams M, Adelman J, Ahissar E, Akaaboune M, Akil H, al’Absi M, Arain F, Arango-Lasprilla JC, Atasoy D , Avila J et al (2017) Building Bridges through Science. Neuron, 96(4), 730-735.
Walker C, Herranz-Martin S, Karyka E, Liao C, Lewis K, Lukashchuk V, Chiang S-C, Ray S, Mulcahy PJ, Jurga M , Tsagakis I et al (2017) C9orf72 Expansion Disrupts ATM-mediated Chromosomal Break Repair. Nature Neuroscience, 20, 1225-1235. View this article in WRRO
Herranz-Martin S, Chandran J, Lewis K, Mulcahy P, Higginbottom A, Walker C, Valenzuela IM-PY, Jones RA, Coldicott I, Iannitti T , Akaaboune M et al (2017) Viral delivery of C9ORF72 hexanucleotide repeat expansions in mice lead to repeat length dependent neuropathology and behavioral deficits.. Disease Models & Mechanisms, 10, 859-868. View this article in WRRO
Hautbergue GM, Castelli LM, Ferraiuolo L, Sanchez-Martinez A, Cooper-Knock J, Higginbottom A, Lin YH, Bauer CS, Dodd JE, myszczynska MA , Alam SM et al (2017) SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits. Nature Communications, 8. View this article in WRRO
Chiang S-C, Meagher M, Kassouf N, Hafezparast M, McKinnon PJ, Haywood R & El-Khamisy SF (2017) Mitochondrial protein-linked DNA breaks perturb mitochondrial gene transcription and trigger free radical–induced DNA damage. Science Advances, 3(4). View this article in WRRO
Meisenberg C, Ashour ME, El-Shafie L, Liao C, Hodgson A, Pilborough A, Khurram SA, Downs JA, Ward SE & El-Khamisy SF (2017) Epigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecan. Nucleic Acids Research, 45(3), 1159-1176. View this article in WRRO
Allam WR, Ashour ME, Waly AA & El-Khamisy S (2017) Role of Protein Linked DNA Breaks in Cancer, 41-58.
Shawky SM, Awad AM, Allam W, Alkordi MH & EL-Khamisy SF (2016) Gold aggregating gold: A novel nanoparticle biosensor approach for the direct quantification of hepatitis C virus RNA in clinical samples. Biosensors and Bioelectronics. View this article in WRRO
Atteya R, Ashour ME, Ibrahim EE, Farag MA & El-Khamisy SF (2016) Chemical screening identifies the β-Carboline Alkaloid Harmine to be synergistically lethal with Doxorubicin. Mechanisms of Ageing and Development. View this article in WRRO
Elsayed W, El-Shafie L, Hassan MK, Farag MA & El-Khamisy SF (2016) Isoeugenol is a selective potentiator of camptothecin cytotoxicity in vertebrate cells lacking TDP1. Scientific Reports, 6, 26626-26626. View this article in WRRO
Mazouzi A, Stukalov A, Müller AC, Chen D, Wiedner M, Prochazkova J, Chiang S-C, Schuster M, Breitwieser FP, Pichlmair A , El-Khamisy SF et al (2016) A Comprehensive Analysis of the Dynamic Response to Aphidicolin-Mediated Replication Stress Uncovers Targets for ATM and ATMIN. Cell Reports, 15(4), 893-908. View this article in WRRO
Hassan MK, Watari H, Mitamura T, Mohamed Z, EL-khamisy SF, Ohba Y & Sakuragi N (2015) P18/Stathmin1 is regulated by miR-31 in ovarian cancer in response to taxane. Oncoscience, 2(3), 294-308. View this article in WRRO
Ashour ME, Atteya R & El-Khamisy SF (2015) Topoisomerase-mediated chromosomal break repair: an emerging player in many games. Nature Reviews Cancer, 15(3), 137-151.
Carroll J, Page TKW, Chiang S-C, Kalmar B, Bode D, Greensmith L, Mckinnon PJ, Thorpe JR, Hafezparast M & El-Khamisy SF (2015) Expression of a pathogenic mutation of SOD1 sensitizes aprataxin-deficient cells and mice to oxidative stress and triggers hallmarks of premature ageing. Human Molecular Genetics, 24(3), 828-840. View this article in WRRO
Ashour ME, El-Shafie L & El-Khamisy SF (2015) DNA Damage Response Pathways in Cancer Predisposition and Progression, 39-74.
Meisenberg C, Gilbert DC, Chalmers A, Haley V, Gollins S, Ward SE & El-Khamisy SF (2015) Clinical and Cellular Roles for TDP1 and TOP1 in Modulating Colorectal Cancer Response to Irinotecan. Molecular Cancer Therapeutics, 14(2), 575-585.
Gómez-Herreros F, Schuurs-Hoeijmakers JHM, McCormack M, Greally MT, Rulten S, Romero-Granados R, Counihan TJ, Chaila E, Conroy J, Ennis S , Delanty N et al (2014) TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function. Nature Genetics, 46(5), 516-521.
Walker S, Meisenberg C, Bibby RA, Askwith T, Williams G, Rininsland FH, Pearl LH, Oliver AW, El-Khamisy S, Ward S & Atack JR (2014) Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors. Analytical Biochemistry, 454, 17-22.
Alagoz M, Wells OS & El-Khamisy SF (2014) TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy. Nucleic Acids Research, 42(5), 3089-3103. View this article in WRRO
Alagoz M, Chiang S-C, Sharma A & El-Khamisy SF (2013) ATM deficiency results in accumulation of DNA-topoisomerase I covalent intermediates in neural cells.. PLoS One, 8(4), e58239. View this article in WRRO
Zeng Z, Sharma A, Ju L, Murai J, Umans L, Vermeire L, Pommier Y, Takeda S, Huylebroeck D, Caldecott KW & El-Khamisy SF (2012) TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1.. Nucleic Acids Res, 40(17), 8371-8380. View this article in WRRO
Lebedeva NA, Rechkunova NI, El-Khamisy SF & Lavrik OI (2012) Tyrosyl-DNA phosphodiesterase 1 initiates repair of apurinic/apyrimidinic sites.. Biochimie, 94(8), 1749-1753.
Hudson JJR, Chiang S-C, Wells OS, Rookyard C & El-Khamisy SF (2012) SUMO modification of the neuroprotective protein TDP1 facilitates chromosomal single-strand break repair.. Nat Commun, 3, 733. View this article in WRRO
Gilbert DC, Chalmers AJ & El-Khamisy SF (2012) Topoisomerase I inhibition in colorectal cancer: biomarkers and therapeutic targets.. Br J Cancer, 106(1), 18-24. View this article in WRRO
Alagoz M, Gilbert DC, El-Khamisy S & Chalmers AJ (2012) DNA repair and resistance to topoisomerase I inhibitors: mechanisms, biomarkers and therapeutic targets.. Curr Med Chem, 19(23), 3874-3885.
El-Khamisy SF (2011) To live or to die: a matter of processing damaged DNA termini in neurons.. EMBO Mol Med, 3(2), 78-88. View this article in WRRO
Zeng Z, Cortés-Ledesma F, El Khamisy SF & Caldecott KW (2011) TDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damage.. J Biol Chem, 286(1), 403-409.
Kerzendorfer C, Whibley A, Carpenter G, Outwin E, Chiang S-C, Turner G, Schwartz C, El-Khamisy S, Raymond FL & O'Driscoll M (2010) Mutations in Cullin 4B result in a human syndrome associated with increased camptothecin-induced topoisomerase I-dependent DNA breaks.. Hum Mol Genet, 19(7), 1324-1334.
Chiang S-C, Carroll J & El-Khamisy SF (2010) TDP1 serine 81 promotes interaction with DNA ligase IIIalpha and facilitates cell survival following DNA damage.. Cell Cycle, 9(3), 588-595.
Cortes Ledesma F, El Khamisy SF, Zuma MC, Osborn K & Caldecott KW (2009) A human 5'-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage.. Nature, 461(7264), 674-678.
Lee Y, Katyal S, Li Y, El-Khamisy SF, Russell HR, Caldecott KW & McKinnon PJ (2009) The genesis of cerebellar interneurons and the prevention of neural DNA damage require XRCC1.. Nat Neurosci, 12(8), 973-980. View this article in WRRO
El-Khamisy SF, Katyal S, Patel P, Ju L, McKinnon PJ & Caldecott KW (2009) Synergistic decrease of DNA single-strand break repair rates in mouse neural cells lacking both Tdp1 and aprataxin.. DNA Repair (Amst), 8(6), 760-766.
Reynolds JJ, El-Khamisy SF & Caldecott KW (2009) Short-patch single-strand break repair in ataxia oculomotor apraxia-1.. Biochem Soc Trans, 37(Pt 3), 577-581.
Reynolds JJ, El-Khamisy SF, Katyal S, Clements P, McKinnon PJ & Caldecott KW (2009) Defective DNA ligation during short-patch single-strand break repair in ataxia oculomotor apraxia 1.. Mol Cell Biol, 29(5), 1354-1362.
El-Khamisy S & Caldecott K (2009) REPAIR OF DNA SINGLE-STRAND BREAKS IN NEURONS: IMPLICATIONS ON HUMAN HEALTH. CELLULAR ONCOLOGY, 31(2), 131-131.
Iles N, Rulten S, El-Khamisy SF & Caldecott KW (2008) APLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks (Molecular and Cellular Biology (2007) 27, 10, (3793-3803)). Molecular and Cellular Biology, 28(10), 3561.
Katyal S, el-Khamisy SF, Russell HR, Li Y, Ju L, Caldecott KW & McKinnon PJ (2007) TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo.. EMBO J, 26(22), 4720-4731.
Rulten SL, Iles N, El-Khamisy SF & Caldecott KW (2007) Characterisation of aprataxin- and PNK-like factor: a novel FHA-domain protein involved in single and double-strand break repair. MUTAGENESIS, 22(6), 449-450.
El-Khamisy SF, Hartsuiker E & Caldecott KW (2007) TDP1 facilitates repair of ionizing radiation-induced DNA single-strand breaks.. DNA Repair (Amst), 6(10), 1485-1495.
Iles N, Rulten S, El-Khamisy SF & Caldecott KW (2007) APLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks.. Mol Cell Biol, 27(10), 3793-3803.
el-Khamisy SF & Caldecott KW (2007) DNA single-strand break repair and spinocerebellar ataxia with axonal neuropathy-1.. Neuroscience, 145(4), 1260-1266.
Ahel I, Rass U, El-Khamisy SF, Katyal S, Clements PM, McKinnon PJ, Caldecott KW & West SC (2006) The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates.. Nature, 443(7112), 713-716.
El-Khamisy SF & Caldecott KW (2006) TDP1-dependent DNA single-strand break repair and neurodegeneration.. Mutagenesis, 21(4), 219-224.
Breslin C, Clements PM, El-Khamisy SF, Petermann E, Iles N & Caldecott KW (2006) Measurement of chromosomal DNA single-strand breaks and replication fork progression rates.. Methods Enzymol, 409, 410-425.
El-Khamisy SF, Saifi GM, Weinfeld M, Johansson F, Helleday T, Lupski JR & Caldecott KW (2005) Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1. NATURE, 434(7029), 108-113.
Loizou JI, El-Khamisy SF, Zlatanou A, Moore DJ, Chan DW, Qin J, Sarno S, Meggio F, Pinna LA & Caldecott KW (2004) The protein kinase CK2 facilitates repair of chromosomal DNA single-strand breaks.. Cell, 117(1), 17-28.
El-Khamisy SF, Masutani M, Suzuki H & Caldecott KW (2003) A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage.. Nucleic Acids Res, 31(19), 5526-5533.
Thomas RC, Zaksauskaite R, Al-Kandari NY, Hyde AC, Abugable AA, El-Khamisy SF & van Eeden FJ () Second generation lethality in RNAseH2a knockout zebrafish. Nucleic Acids Research.
Kassem PH, Montasser IF, Mahmoud RM, Ghorab RA, AbdelHakam DA, Fathi MELSA, Wahed MAA, Mohey K, Ibrahim M, Hadidi ME , Masssoud YM et al () Genomic landscape of hepatocellular carcinoma in Egyptian patients by whole exome sequencing. BMC Medical Genomics, 17(1).
Barnieh FM, Morais GR, Loadman PM, Falconer RA & El‐Khamisy SF () Hypoxia‐Responsive Prodrug of ATR Inhibitor, AZD6738, Selectively Eradicates Treatment‐Resistant Cancer Cells. Advanced Science.
Allam WR, Hegazy MT, Hussein MA, Zoheir N, Quartuccio L, El-Khamisy SF & Ragab G () A comparative study of different antiviral treatment protocols in HCV related cryoglobulinemic vasculitis. Scientific Reports, 14(1), 11840.
Edwards HR, Jones H, Moseley J, Marshall T, El-Khamisy S, Aung MN & Farrow M () Exercise Interventions for the Management of Sarcopenia: Possibilities and Challenges. Physical & Occupational Therapy In Geriatrics, 1-24.
Lyon RF, Southam HM, Trevitt C, Liao C, El-Khamisy S, Poole RK & Williamson MP () CORM-3 induces DNA damage through Ru(II) binding to DNA. Biochemical Journal.
M. Shawky S, A. Abo-AlHassan A, Lill H, Bald D, F.EL-Khamisy S & M. Ebeid E-Z () https://www.omicsonline.org/open-access/biodegradable-nanocapsules-containing-a-nanobiotechnological-complex-for-the-invitro-suppression-of-a-melanoma-cell-line-b16f10-JNCR-1000102.php?aid=76290. Journal of Nanosciences: Current Research, 01(01).
Meisenberg C () TDP1/TOP1 Ratio as a Promising Indicator for the Response of Small Cell Lung Cancer to Topotecan. Journal of Cancer Science & Therapy, 06(07). View this article in WRRO
Carmell N, Rominiyi O, Myers KN, McGarrity-Cottrell C, Vanderlinden A, Lad N, Perroux-David E, El-Khamisy SF, Fernando M, Finegan KG , Brown S et al () Identification and Validation of ERK5 as a DNA Damage Modulating Drug Target in Glioblastoma. Cancers, 13(5), 944-944.
Kok JR, Palminha NM, Dos Santos Souza C, El-Khamisy SF & Ferraiuolo L () DNA damage as a mechanism of neurodegeneration in ALS and a contributor to astrocyte toxicity. Cellular and Molecular Life Sciences.
Griffin J, Chen Y, Catto JWF & El-Khamisy S () Gene of the month: NKX3.1. Journal of Clinical Pathology.

Chapters

Shnyder SD, Chatterji SK & El-Khamisy S (2022) Animal Models in Monoclonal Immunoglobulin-Related Diseases, Paraproteinemia and Related Disorders (pp. 57-77). Springer International Publishing
Chandran JS, Scarrott JM, Shaw P & Azzouz M (2017) Gene Therapy in the Nervous System: Failures and Successes In El-Khamisy S (Ed.), Personalised Medicine Lessons from Neurodegeneration to Cancer Springer
Allen C, Shaw PJ & Ferraiuolo L (2017) Can Astrocytes Be a Target for Precision Medicine? In El-Khamisy (Ed.), Personalised Medicine View this article in WRRO
El-Khamisy S (2017) Personalised Medicine Lessons from Neurodegeneration to Cancer Preface, PERSONALISED MEDICINE: LESSONS FROM NEURODEGENERATION TO CANCER (pp. V-V).
Abugable AA, Awwad DA, Fleifel D, Ali MM, El-Khamisy S & Elserafy M (2017) Personalised Medicine: Genome Maintenance Lessons Learned from Studies in Yeast as a Model Organism, Advances in Experimental Medicine and Biology (pp. 157-178). Springer International Publishing
Wells OS & El-Khamisy SF (2015) Autosomal Recessive Ataxias Due to Defects in DNA Repair, Movement Disorders (pp. 1033-1041). Elsevier
Wells OS & El-Khamisy SF (2015) Autosomal Recessive Ataxias Due to Defects in DNA Repair, Movement Disorders: Genetics and Models: Second Edition (pp. 1033-1041).

Conference proceedings papers

Crane H, Hunter K & El-Khamisy S (2023) The Role of R-loops in the Development of Cisplatin Resistance in Oropharyngeal Squamous Cell Carcinoma (OPSCC). JOURNAL OF PATHOLOGY, Vol. 261(SUPPL1) (pp S62-S62)
Crane H, Hunter K & El-Khamisy SF (2022) Exploration of the transcriptomic landscape of HPV-positive and HPV-negative oropharyngeal squamous cell carcinoma upon development of cisplatin resistance. VIRCHOWS ARCHIV, Vol. 481(SUPPL 1) (pp S73-S73)
Al Saeedy D, Abuhijjleh RK, Gouda A, El-Khamisy SF & Al-Abd AM (2022) Modulating the polymorphic UGT1A1 gene to enhance camptothecin anti-colorectal effect. CANCER RESEARCH, Vol. 82(12)
Loutfy SA, Fattah NFA, Barakat AB, Alfarouk OR, Hashem TM, Osman AM, Metwally SA, Abo-Shadi MA, Helal AM, Habib SA , Sherif AAE et al (2021) Abstract 2512: BRCA1 and BRCA2 mutations and its clinical relevance among egyptian breast cancer women. Molecular and Cellular Biology/Genetics
Loutfy SA, Fattah NFA, Barakat AB, Alfarouk OR, Hashem TM, Osman AM, Metwally SA, Abo-Shadi MA, Helal AM, Habib SA , El Sherif AA et al (2021) BRCA1 and BRCA2 mutations and its clinical relevance among egyptian breast cancer women.. CANCER RESEARCH, Vol. 81(13)
Crane H, Hunter K & El-Khamisy S (2020) The effect of E6 and E7 knockdown and PARP inhibition on cisplatin sensitivity in oropharyngeal squamous cell carcinoma. VIRCHOWS ARCHIV, Vol. 477 (pp S76-S76)
Samer SE, Maghraby AA, Zook Y, Haiba A, Lazem S, Shawky SM & Elkhamisy SF (2018) Al-Metyaf: A smart phone application for colorimetric analysis. ACM International Conference Proceeding Series (pp 391-396)
Hegazy MT, Allam W, Hussein MA, Zoheir N, Quartuccio L, Cacoub P, Doss W, Ellawindi MI, Fawzy M, Guillevin L , El Ray A et al (2018) DNA Damage and Repair in Patients with Cryoglobulinemic Vasculitis Treated with Direct Anti-HCV Drugs. ARTHRITIS & RHEUMATOLOGY, Vol. 70
Hassan M, Mohamed Z, Okasha S, Watari H & EL-Khamisy S (2017) COMPARATIVE MIRNA MICROARRAY PROFILING INDICATES MIR-363 PROMOTES CHEMORESISTANCE IN OVARIAN CANCER CELLS BY TARGETING THE HIPPO MEMBER, LATS2. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, Vol. 27 (pp 1952-1952)
Sakuragi N, Farah MK, Mohamed Z, Okasha S, Watari H, Mitamura T, Khamisy SE & Ohba Y (2017) Abstract LB-323: Comparative miRNA microarray profiling indicates miR-363 promotes chemoresistance in ovarian cancer cells by targeting the Hippo member, LATS2. Molecular and Cellular Biology, Genetics
Hegazy MT, Hussein MA, Quartuccio L, Fawzy M, Zoheir N, Ellawindi MI, Bond M, Mazzaro C, El Ray A, El Raziky MES , El Serafy M et al (2016) Treatment of Cryoglobulinemic Vasculitis with Sofosbuvir in Four Combination Protocols. ARTHRITIS & RHEUMATOLOGY, Vol. 68
Lebedeva N, Rechkunova N, El-Khamisy S & Lavrik O (2013) Tyrosyl-DNA phosphodiesterase 1-a new player in base excision repair. FEBS JOURNAL, Vol. 280 (pp 63-64)

Preprints

Crane H, Carr I, Hunter KD & El-Khamisy SF (2024) Senataxin modulates resistance to cisplatin through an R-loop mediated mechanism in HPV-associated Head and Neck Squamous Cell Carcinoma, Cold Spring Harbor Laboratory.
Edwards HR, Jones H, Mosely J, Marshall T, El-Khamisy SF, Aung MN & Farrow M () Exercise Interventions for the Management of Sarcopenia: Possibilities and Challenges, Research Square Platform LLC.
Halliwell JA, Frith TJR, Laing O, Price CJ, Bower OJ, Stavish D, Gokhale PJ, Hewitt Z, El-Khamisy SF, Barbaric I & Andrews PW () Nucleosides rescue replication-mediated genome instability of human pluripotent stem cells, Cold Spring Harbor Laboratory. View this article in WRRO
Kim HR, Santhakumar K, Markham E, Baldera D, Bryant HE, El-Khamisy SF & van Eeden FJ () The investigation of the role of VHL-HIF signaling in DNA repair and apoptosis in zebrafish, Cold Spring Harbor Laboratory.
Shafei AE-S, Matboli M, Ali MA, Nagy Z, Reda M, Salah M, Hamdy A, Abdelgawad M, Ashry A, Tarek M , Saber O et al () Competing endogenous RNA network: Potential entrants to gene editing in Hepatocellular Carcinoma Gene editing of ceRNA in Hepatocellular Carcinoma, Cold Spring Harbor Laboratory.

Research group

I welcome applications from self-funded prospective home and international PhD students; see examples of possible projects below.

You can apply for a PhD position in MBB here.

Contact me at S.El-Khamisy@sheffield.ac.uk for further information.

Teaching activities

Level 3 Modules

MBB313 Genome Stability and Genetic Change

Level 2 Modules

MBB262 Genetics 2

School of Biosciences

School of Biosciences

Professor Sherif El-Khamisy

Career history

Video animations summarising recent research discoveries

Major scientific accomplishments

Honours and distinctions

Featured publications

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Journal articles

Chapters

Conference proceedings papers

Preprints

Level 3 Modules

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