Member Publications
Recent publications from members of the Mellanby Centre.
![Blue-tinted x-ray of a spinal column on a black background](http://cdn.sheffield.ac.uk/sites/default/files/styles/mobile_single_column_1x/public/2022-09/Bone%20Image%202.png.jpg?itok=otACiqws)
Publications
Journal articles
- The incidence of fractures in children under two years of age: a systematic review. BMC Musculoskeletal Disorders, 25(1), 528.
- PERI-operative biologic DMARD management: Stoppage or COntinuation during orthoPaEdic operations (the PERISCOPE trial) – a study protocol for a pragmatic, UK multicentre, superiority randomised controlled trial with an internal pilot, economic evaluation and nested qualitative study. BMJ Open, 14(6), e084997-e084997.
- Assessment and management of fracture risk in men with prostate cancer taking androgen deprivation therapy: a retrospective observational primary care database study. British Journal of General Practice, 74(suppl 1), bjgp24X737637-bjgp24X737637.
- The impact of androgen deprivation therapy on bone microarchitecture in men with prostate cancer: A longitudinal observational study (The ANTELOPE Study). Journal of Bone Oncology, 47. View this article in WRRO
- The role of IL-1B in breast cancer bone metastasis. Journal of Bone Oncology, 46, 100608-100608.
- Implications of bone metastasis on response to systemic therapy in patients with advanced renal cell carcinoma: A systematic literature review. Cancer Treatment Reviews, 102792-102792.
- Sialic acid blockade inhibits the metastatic spread of prostate cancer to bone. eBioMedicine, 104, 105163-105163.
- Once-weekly semaglutide versus placebo in adults with increased fracture risk: a randomised, double-blinded, two-centre, phase 2 trial. eClinicalMedicine, 72, 102624-102624.
- DEVELOPMENT AND IMPLEMENTATION OF THE INFORM GUIDELINES FOR THE TREATMENT AND MANAGEMENT OF PROSTHETIC HIP INFECTION. Orthopaedic Proceedings, 106-B(SUPP_6), 40-40.
- ESTIMATING THE COSTS, HEALTH-RELATED QUALITY OF LIFE, AND REVISION RISK IN THE YEAR AFTER ELECTIVE PRIMARY AND REVISION HIP ARTHROPLASTY PROCEDURES BY IMPLANT BEARING MATERIALS: AN ANALYSIS OF LINKED DATA FROM THE NATIONAL JOINT REGISTRY (NJR), HOSPITAL EPISODE STATISTICS (HES), AND PATIENT-REPORTED OUTCOME MEASURES (PROMS) FOR ENGLISH PATIENTS. Orthopaedic Proceedings, 106-B(SUPP_6), 58-58.
- BEARING SURFACE MATERIALS AND THE RISK OF REVISION FOLLOWING PRIMARY TOTAL HIP ARTHROPLASTY: A COHORT ANALYSIS OF 1,026,481 HIP ARTHROPLASTIES FROM THE NATIONAL JOINT REGISTRY. Orthopaedic Proceedings, 106-B(SUPP_6), 17-17.
- Test 1, 1-48.
- Test 2, 49-98.
- Bone mineral density as a surrogate endpoint for fracture risk reduction in clinical trials of osteoporosis therapies: an update on SABRE. The Lancet Diabetes & Endocrinology.
- OA30 Primary osteoarthritis chondrocyte map of chromatin conformation reveals novel effector genes. Rheumatology, 63(Supplement_1).
- Automatic segmentation of lower limb muscles from MR images of post-menopausal women based on deep learning and data augmentation. PLOS ONE, 19(4). View this article in WRRO
- The impact of sedation on the quality of initial skeletal surveys performed for suspected physical abuse in children: a comparative two-centre audit. Clinical Radiology.
- PROFILING METHYLATION IN PRIMARY OSTEOARTHRITIS CARTILAGE. Osteoarthritis and Cartilage, 32, S484-S484.
- The molecular environment of osteoarthritis risk genes in primary cartilage. Osteoarthritis and Cartilage, 32, S475-S476.
- #30. Fractures in metastatic hormone-sensitive prostate cancer (mHSPC). Results from two phase 3 trials from the STAMPEDE platform. Journal of Bone Oncology, 45, 100568-100568.
- BoHFAB. The impact of adjuvant zoledronate therapy on bone health in postmenopausal patients with early breast cancer. Journal of Bone Oncology, 45, 100529-100529.
- #32. Identification of proteins regulating the metastatic spread of breast cancer to bone: Proteomic analysis of the role of the pro-metastatic transcription factor TWIST1 and the gene target micro-RNA (miR-10b). Journal of Bone Oncology, 45, 100570-100570.
- #28. Identification of key proteins within prostate cancer derived exosomes and their role in priming the pre-metastatic niche. Journal of Bone Oncology, 45, 100566-100566.
- PRIMARY OSTEOARTHRITIS CHONDROCYTE MAP OF CHROMATIN CONFORMATION REVEALS NOVEL PUTATIVE EFFECTOR GENES. Osteoarthritis and Cartilage, 32, S467-S468.
- No evidence of association between either Modic change or disc degeneration and five circulating inflammatory proteins. JOR SPINE, 7(1).
- Week-by-week changes in serum levels of bone-related circulating microRNAs and bone turnover markers. JBMR Plus, 8(5).
- REST: a preoperative tailored sleep intervention for patients undergoing total knee replacement – feasibility study for a randomised controlled trial. BMJ Open, 14(3), e078785-e078785.
- Primary osteoarthritis chondrocyte map of chromatin conformation reveals novel candidate effector genes. Annals of the Rheumatic Diseases. View this article in WRRO
- Asia-Pacific consensus on long-term and sequential therapy for osteoporosis. Osteoporosis and Sarcopenia.
- Fabrication and characterisation of random and aligned electrospun scaffolds to investigate hypothalamic stem/progenitor cell behaviour. Engineered Regeneration, 5(1), 11-20.
- Automatic segmentation of skeletal muscles from MR images using modified U-Net and a novel data augmentation approach. Frontiers in Bioengineering and Biotechnology, 12. View this article in WRRO
- Effectiveness and cost effectiveness of pharmacological thromboprophylaxis for medical inpatients: decision analysis modelling study. BMJ Medicine, 3(1), e000408-e000408.
- DXA-based statistical models of shape and intensity outperform aBMD hip fracture prediction: A retrospective study. Bone, 182, 117051-117051.
- Risk of Fractures and Falls in Men with Advanced or Metastatic Prostate Cancer Receiving Androgen Deprivation Therapy and Treated with Novel Androgen Receptor Signalling Inhibitors: A Systematic Review and Meta-analysis of Randomised Controlled Trials. European Urology Oncology.
- An online clinical decision tool to screen for vertebral fragility fractures (Vfrac) in older women presenting with back pain in general practice: protocol for a feasibility study in preparation for a future cluster randomised controlled trial. Archives of Osteoporosis, 19(1).
- The loading direction dramatically affects the mechanical properties of the mouse tibia. Frontiers in Bioengineering and Biotechnology, 12. View this article in WRRO
- The RNA binding proteins LARP4A and LARP4B promote sarcoma and carcinoma growth and metastasis. iScience, 109288-109288.
- Equivalence trial of proposed denosumab biosimilar GP2411 and reference denosumab in postmenopausal osteoporosis: the ROSALIA study. Journal of Bone and Mineral Research, 39(3), 202-210.
- Combining PTH(1‐34) and mechanical loading has increased benefit to tibia bone mechanics in ovariectomised mice. Journal of Orthopaedic Research. View this article in WRRO
- Estimating the value of future research into thromboprophylaxis for women during pregnancy and after delivery: a value of information analysis. Journal of Thrombosis and Haemostasis.
- THE METABOLIC ROLE OF IL-4 AND IL-10 IN INTERVERTEBRAL DISC DEGENERATION. Orthopaedic Proceedings, 106-B(SUPP_2), 93-93.
- Clinical Use of Trabecular Bone Score: The 2023 ISCD Official Positions. Journal of Clinical Densitometry, 27(1), 101452-101452.
- JD-312 – A novel small molecule that facilitates cartilage repair and alleviates osteoarthritis progression. Journal of Orthopaedic Translation, 44, 60-71.
- Radium-223 in women with hormone receptor-positive bone-metastatic breast cancer receiving endocrine therapy: pooled analysis of two international, phase 2, randomized, double-blind, placebo-controlled trials. Breast Cancer Research and Treatment, 204(2), 249-259.
- Cortical thickness adaptation to combined mechanical loading and parathyroid hormone treatments is site specific and synergistic in the mouse tibia model. Bone, 180, 116994-116994.
- Electrospinning polymersomes into bead-on-string polyethylene oxide fibres for the delivery of biopharmaceuticals to mucosal epithelia. Biomaterials Advances, 157. View this article in WRRO
- Biallelic CRELD1 variants cause a multisystem syndrome, including neurodevelopmental phenotypes, cardiac dysrhythmias, and frequent infections. Genetics in Medicine, 26(2), 101023-101023.
- Disparities in paediatric radiology research publications from low- and lower middle-income countries: a time for change. Pediatric Radiology, 1-10. View this article in WRRO
- Injectable hydrogel induces regeneration of naturally degenerate human intervertebral discs in a loaded organ culture model.. Acta Biomaterialia.
- Development and application of simulation modelling for orthopaedic elective resource planning in England. BMJ Open, 13(12), e076221-e076221.
- Abstract B109: MTHFD1/2 inhibitor TH9619 targets the DNA damage response and causes cancer-specific folate trapping with an unprecedented therapeutic window. Molecular Cancer Therapeutics, 22(12_Supplement), B109-B109.
- A new FRAX model for Brazil. Archives of Osteoporosis, 18(1), 144.
- Protocol of a randomised trial of teriparatide followed by zoledronic acid to reduce fracture risk in adults with osteogenesis imperfecta. BMJ Open, 13(11), e078164-e078164.
- Standard Versus Modified Ipilimumab, in Combination With Nivolumab, in Advanced Renal Cell Carcinoma: A Randomized Phase II Trial (PRISM).. J Clin Oncol, JCO2300236.
- Targeting MTHFD2 to exploit cancer-specific metabolism and the DNA damage response. Cancer Research.
- Radiotherapy to regional nodes in early breast cancer: an individual patient data meta-analysis of 14 324 women in 16 trials. The Lancet, 402(10416), 1991-2003.
- Accelerated versus standard epirubicin followed by cyclophosphamide, methotrexate, and fluorouracil or capecitabine as adjuvant therapy for breast cancer (UK TACT2; CRUK/05/19): quality of life results from a multicentre, phase 3, open-label, randomised, controlled trial. The Lancet Oncology, 24(12), 1359-1374.
- Diagnosis of metaphyseal fractures in infants and young children with suspected inflicted injury: a systematic review of cross-sectional imaging techniques. Clinical Radiology.
- Cost-Effectiveness Analysis of CT-Based Finite Element Modeling for Osteoporosis Screening in Secondary Fracture Prevention: An Early Health Technology Assessment in the Netherlands. MDM Policy & Practice, 8(2).
- Impact of leptin deficiency on male tibia and vertebral body
3D bone architecture independent of changes in body weight. Physiological Reports, 11(19). - PB1532 How Can We Improve Recruitment to Trials for Prevention of Venous Thromboembolism during Pregnancy and the Puerperium? A Qualitative Evaluation of the Patients' Perspective. Research and Practice in Thrombosis and Haemostasis, 7, 101939-101939.
- Adjusting Trabecular Bone Score (TBS) for Level-specific Differences Reduces FRAX®-based Treatment Reclassification in Patients with Vertebral Exclusions: The Manitoba BMD Registry. Journal of Clinical Densitometry, 101429-101429.
- FRAX® adjustment using renormalized trabecular bone score (TBS) from L1 alone may be optimal for fracture prediction: The Manitoba BMD registry. Journal of Clinical Densitometry, 26(4), 101430-101430.
- 1768MO Incidence of fracture related hospitalisations in men with de novo high risk localised and metastatic hormone sensitive prostate cancer: Analysis of routinely collected healthcare data from the STAMPEDE docetaxel and zoledronic acid comparisons. Annals of Oncology, 34, S956-S957.
- Enhanced antibacterial ability of electrospun PCL scaffolds incorporating ZnO nanowires. International Journal of Molecular Sciences, 24(19). View this article in WRRO
- Effect of muscle forces on femur during level walking using a virtual population of older women. Methods in molecular biology (Clifton, N.J.), MIMB 2716, 335-349. View this article in WRRO
- Cementing Techniques In Knee Surgery (CeTIKS): a UK expert consensus study.. Bone Jt Open, 4(9), 682-688.
- Research prioritisation on prevention and management of preterm birth in low and middle-income countries (LMICs) with a special focus on Bangladesh using the Child Health and Nutrition Research Initiative (CHNRI) method. Journal of Global Health, 13, 07004.
- Use of genome sequencing to hunt for cryptic second-hit variants: analysis of 31 cases recruited to the 100 000 Genomes Project.. J Med Genet.
- Concerns Regarding Neuroimaging of Asymptomatic Infant Siblings of Children Who Experienced Abuse—Reply. JAMA Pediatrics, 177(8), 869-869.
- SUPPORT AND TREATMENT AFTER JOINT REPLACEMENT (STAR): LONG-TERM FOLLOW-UP OF A CARE PATHWAY FOR PATIENTS WITH CHRONIC PAIN AFTER KNEE ARTHROPLASTY. Orthopaedic Proceedings, 105-B(SUPP_13), 50-50.
- HNRNPC haploinsufficiency affects alternative splicing of intellectual disability-associated genes and causes a neurodevelopmental disorder. The American Journal of Human Genetics, 110(8), 1414-1435.
- Cell clusters in intervertebral disc degeneration: An attempted repair mechanism aborted via apoptosis. Anatomy & Cell Biology.
- Engagement with a local African-Caribbean community to explore perspectives and research priorities among Black men for prostate cancer using a co-participatory approach. British Journal of General Practice, 73(suppl 1), bjgp23X733797-bjgp23X733797.
- Race-specific FRAX models are evidence-based and support equitable care: a response to the ASBMR Task Force report on Clinical Algorithms for Fracture Risk. Osteoporosis International.
- The potential therapeutic applications of long non-coding RNAs. Journal of Translational Genetics and Genomics, 8(2), 225-43.
- IOF position on scientists and societies operating in conflict zones. Osteoporosis International.
- Predictive value of sarcopenia components for all-cause mortality: findings from population-based cohorts. Aging Clinical and Experimental Research, 36(1).
- Update on fracture risk assessment in osteoporosis. Current Opinion in Endocrinology, Diabetes & Obesity.
- Periprosthetic Joint Infection After Total Knee Arthroplasty With or Without Antibiotic Bone Cement. JAMA Network Open, 7(5), e2412898-e2412898.
- Sulfated Hydrogels as Primary Intervertebral Disc Cell Culture Systems. Gels, 10(5), 330-330.
- Pre-treatment bone mineral density (BMD) and the benefit of pharmacologic treatment on fracture risk and BMD change: analysis from the FNIH-ASBMR SABRE project. Journal of Bone and Mineral Research.
- Impact of the COVID‐19 pandemic on the productivity and career prospects of musculoskeletal researchers. Journal of Orthopaedic Research.
- Supported exercise TrAining for Men wIth prostate caNcer on Androgen deprivation therapy (STAMINA): study protocol for a randomised controlled trial of the clinical and cost-effectiveness of the STAMINA lifestyle intervention compared with optimised usual care, including internal pilot and parallel process evaluation. Trials, 25(1).
- Evaluation of venous thromboembolism risk assessment models for hospital inpatients: the VTEAM evidence synthesis. Health Technology Assessment, 1-166.
- Bisphosphonate alternative regimens for the prevention of osteoporotic fragility fractures: BLAST-OFF, a mixed-methods study. Health Technology Assessment, 1-169.
- Medical Management for Fracture Prevention in Children with Osteogenesis Imperfecta. Calcified Tissue International.
- Anti-fracture treatment efficacy by age. Journal of Bone and Mineral Research.
- Clinical and molecular characterization of patients with
YWHAG ‐related epilepsy. Epilepsia. - Evidence-Based Guideline for the management of osteoporosis in men. Nature Reviews Rheumatology.
- Potential of Notochordal Cells within Injectable Biomaterials to Promote Intervertebral Disc Regeneration. European Cells and Materials, 47, 30-50.
- ASXL3‐related disorder: Molecular phenotyping and comprehensive review providing insights into disease mechanism. Clinical Genetics.
- Sarcopenia definitions and their association with fracture risk in older Swedish women. Journal of Bone and Mineral Research.
- The implications of competing risks and direct treatment disutility in cardiovascular disease and osteoporotic fracture: risk prediction and cost effectiveness analysis. Health and Social Care Delivery Research, 1-275.
- Cabozantinib and Axitinib After Vascular Endothelial Growth Factor Therapy in Patients with Advanced Renal Cell Carcinoma: A Retrospective Cohort Study from England. Drugs - Real World Outcomes.
- A meta-analysis of previous falls and subsequent fracture risk in cohort studies. Osteoporosis International.
- Is it possible to predict which patients are most likely to benefit from intra‐articular corticosteroid injections? A systematic review. International Journal of Rheumatic Diseases.
- Adjuvant bisphosphonate therapy and bone health. Journal of Bone and Mineral Research.
- Bone remodelling and responsiveness to mechanical stimuli in individuals with type 1 diabetes mellitus. Journal of Bone and Mineral Research.
- FRAX predicts cardiovascular risk in women undergoing osteoporosis screening: the Manitoba BMD registry. Journal of Bone and Mineral Research.
- Efficacy of Osteoporosis Medications in Patients with Type 2 Diabetes. Current Osteoporosis Reports.
- Changes in collagen type I C-telopeptide and procollagen type I N-terminal propeptide during the menopause transition. The Journal of Clinical Endocrinology & Metabolism.
- Fracture prediction in rheumatoid arthritis: validation of FRAX with bone mineral density for incident major osteoporotic fractures. Rheumatology.
- Celebrating 50 years of Pediatric Radiology. Pediatric Radiology, 53(13), 2571-2571.
- The impact of restricted provision of publicly funded elective hip and knee joints replacement during the COVID-19 pandemic in England. PLOS ONE, 18(11), e0294304-e0294304.
- Cellular Responses to Extracellular Vesicles as Potential Markers of Colorectal Cancer Progression. International Journal of Molecular Sciences, 24(23), 16755-16755.
- Epigenomic profiling of the infrapatellar fat pad in osteoarthritis. Human Molecular Genetics.
- Changes in the immune landscape of TNBC after neoadjuvant chemotherapy: correlation with relapse. Frontiers in Immunology, 14.
- MAF amplification licenses ERα through epigenetic remodelling to drive breast cancer metastasis. Nature Cell Biology.
- Notochordal cell-derived matrix inhibits MAPK signaling in the degenerative disc environment. European Cells and Materials, 46, 57-90.
- Children with hypophosphatasia treated with asfotase alfa: analysis from the UK Patients Cohort. Endocrine Abstracts.
- Service evaluation of the metabolic bone centre primary hyperparathyroidism registry. Endocrine Abstracts.
- Antiresorptive Versus Anabolic Therapy in Managing Osteoporosis in People with Type 1 and Type 2 Diabetes. JBMR Plus.
- Sex‐ and Age Group‐Specific Fracture Incidence Rates Trends for Type 1 and 2 Diabetes Mellitus. JBMR Plus.
- Selenium status and its determinants in very old adults: Insights from the Newcastle 85+ Study. British Journal of Nutrition, 1-31.
- An overview of the use of the fracture risk assessment tool (FRAX) in osteoporosis. Journal of Endocrinological Investigation.
- Cartilaginous endplates: A comprehensive review on a neglected structure in intervertebral disc research. JOR SPINE.
- Cortical bone adaptation response is region specific, but not peak load dependent: insights from $$mu$$CT image analysis and mechanostat simulations of the mouse tibia loading model. Biomechanics and Modeling in Mechanobiology.
- Disparities in paediatric radiology research publications from low- and lower middle-income countries: Pediatric Radiology editors as advocates. Pediatric Radiology.
- Effect of
BMI‐Discordant Abdominal Tissue Thickness on Fracture Probability: ARegistry‐Based Study. Journal of Bone and Mineral Research. - Neonatal Hip Loading in Developmental Dysplasia: Finite Element Simulation of Proximal Femur Growth and Treatment. HSS Journal®: The Musculoskeletal Journal of Hospital for Special Surgery.
- Cementing Techniques In Knee Surgery (CeTIKS): a UK expert consensus study. Bone & Joint Open, 4(9), 682-688.
- Adjusting FRAX Estimates of Fracture Probability Based on a Positive Vertebral Fracture Assessment. JAMA Network Open, 6(8), e2329253-e2329253.
- Previous fracture and subsequent fracture risk: a meta-analysis to update FRAX. Osteoporosis International.
- The use of antibiotic-loaded bone cement and systemic antibiotic prophylactic use in 2,971,357 primary total knee arthroplasties from 2010 to 2020: an international register-based observational study among countries in Africa, Europe, North America, and Oceania. Acta Orthopaedica, 94, 416-425.
- Evaluating the Usefulness and Ease of Use of a Next-Generation–Connected Drug Delivery Device for Growth Hormone Therapy: Qualitative Study of Health Care Professionals’ Perceptions. JMIR Human Factors, 10, e46893-e46893.
Chapters
- Comparisons between Different Polychemotherapy Regimens for Early Breast Cancer: Meta-Analyses of Long-Term Outcome among 100,000 Women in 123 Randomised Trials, 50 Landmark Papers every Breast Surgeon Should Know (pp. 159-164). CRC Press
- Adjuvant Capecitabine for Breast Cancer after Preoperative Chemotherapy: CREATE-X, 50 Landmark Papers every Breast Surgeon Should Know (pp. 165-170). CRC Press
- Adjuvant Zoledronic Acid in Patients with Early Breast Cancer: Final Efficacy Analysis of the AZURE (BIG 01/04) Randomised Open-Label Phase 3 Trial, 50 Landmark Papers every Breast Surgeon Should Know (pp. 237-242). CRC Press
- Long-Term Effects of Anastrozole on Bone Mineral Density: 7-Year Results from the ATAC Trial, 50 Landmark Papers every Breast Surgeon Should Know (pp. 243-248). CRC Press
- Test 9, Paediatric Radiology Rapid Reporting (pp. 357-397). Springer International Publishing
- Test 11, Paediatric Radiology Rapid Reporting (pp. 439-480). Springer International Publishing
- Test 6, Paediatric Radiology Rapid Reporting (pp. 229-269). Springer International Publishing
- Test 13, Paediatric Radiology Rapid Reporting (pp. 525-569). Springer International Publishing
- Test 7, Paediatric Radiology Rapid Reporting (pp. 271-313). Springer International Publishing
- Test 12, Paediatric Radiology Rapid Reporting (pp. 481-523). Springer International Publishing
- Test 8, Paediatric Radiology Rapid Reporting (pp. 315-355). Springer International Publishing
- Test 5, Paediatric Radiology Rapid Reporting (pp. 185-227). Springer International Publishing
- Test 3, Paediatric Radiology Rapid Reporting (pp. 99-142). Springer International Publishing
- Imaging: Radiology, Pediatric, and Child Abuse—Skeletal Imaging, Reference Module in Social Sciences Elsevier
- Test 10, Paediatric Radiology Rapid Reporting (pp. 399-437). Springer International Publishing
Conference proceedings papers
Reports
Other
- Figure S1. from Targeting MTHFD2 to Exploit Cancer-Specific Metabolism and the DNA Damage Response.
- Data from Targeting MTHFD2 to Exploit Cancer-Specific Metabolism and the DNA Damage Response.
- Figure S1. from Targeting MTHFD2 to Exploit Cancer-Specific Metabolism and the DNA Damage Response.
- Data from Targeting MTHFD2 to Exploit Cancer-Specific Metabolism and the DNA Damage Response.
Preprints
- Receptor activity modifying protein modulation of parathyroid hormone-1 receptor function and signalling, Cold Spring Harbor Laboratory.
- Targeting of a STING Agonist to Perivascular Macrophages in Prostate Tumors Delays Resistance to Androgen Deprivation Therapy, Cold Spring Harbor Laboratory.
- Fracture risk assessment in men with prostate cancer requiring long-term androgen deprivation therapy: a systematic scoping review using the i-PARIHS implementation framework, Research Square Platform LLC.
- What influences women’s decisions to participate in trials for prevention of venous thromboembolism during pregnancy and the puerperium: a qualitative study, Research Square Platform LLC.
- The impact of HIV infection on skeletal maturity in peripubertal children in Zimbabwe: a cross sectional study, Research Square Platform LLC.
- Large-scale evaluation of outcomes following a genetic diagnosis in children with severe developmental disorders.