Member Publications
Recent publications from members of the Mellanby Centre.

Publications
Journal articles
- Altered vertebral biomechanical properties in prostate cancer patients following androgen deprivation therapy. Bone, 195, 117465-117465.
- Symmetric normalization algorithm for estimating physiological strain in bones. European Journal of Mechanics - A/Solids, 111, 105539-105539.
- Application and validation of semiautomatic quantification of immunohistochemically stained sections for low cellular tissue such as intervertebral disc using QuPath. JOR Spine, 8(1). View this article in WRRO
- In children under two years of age, does the bone health index value differ between those with and without osteogenesis imperfecta?. Bone, 117467-117467.
- Expanding the Phenotypic Spectrum of HNRNPU-Related Disorder, Documenting the First Familial Presentation and Comprehensive Review.. Am J Med Genet A, e64013.
- A surrogate FRAX model for Mongolia. Archives of Osteoporosis, 20(1), 27.
- Ex Vivo and In Vitro Proteomic Approach to Elucidate the Relevance of IL-4 and IL-10 in Intervertebral Disc Pathophysiology.. JOR Spine, 8(1), e70048.
- A Cryptic
CBFB Deletion–Inversion Expands the Mutational Spectrum of Variants Associated With Cleidocranial Dysplasia. Clinical Genetics. - Explorative Study of Modulatory Effects of Notochordal Cell‐Derived Extracellular Vesicles on the
IL ‐1β‐Induced Catabolic Cascade in Nucleus Pulposus Cell Pellets and Explants. JOR SPINE, 8(1). - Assessing and Managing Primary Hyperparathyroidism and Fracture Risk in England: A Survey of Medical Professionals. Journal of the Endocrine Society, 9(2).
- The publication fate of abstracts awarded prizes at European Society of Paediatric Radiology annual scientific meetings. Pediatric Radiology.
- Bone Turnover Markers Predict Changes in Bone Mineral Density in Men Treated with Abaloparatide: Results from ATOM.. J Bone Miner Res.
- Assessment of fracture risk with FRAX and FRAXplus. Gaceta Médica de México, 160(4).
- Degeneration of the nucleus pulposus affects the internal volumetric strains and failure location of adjacent human metastatic vertebral bodies. Acta Biomaterialia.
- Which paediatric fractures lack research evidence regarding their diagnosis using artificial intelligence? A systematic review. The Royal College of Radiologists Open, 3, 100165-100165.
- Assessing the performance of a deep learning algorithm for detection of scaphoid fractures in paediatric radiographs. The Royal College of Radiologists Open, 3, 100202-100202.
- Long term health outcomes in people with diabetes 12 months after hospitalisation with COVID-19 in the UK: a prospective cohort study. eClinicalMedicine, 79. View this article in WRRO
- SB16 versus reference denosumab in postmenopausal women with osteoporosis: 18-month outcomes of a phase III randomized clinical trial. Bone, 192, 117371-117371.
- Rapid assessment of the osteogenic capacity of hydroxyapatite/aragonite using a murine tibial periosteal ossification model. Bioactive Materials, 45, 257-273.
- Microstructure of the human metastatic vertebral body. Frontiers in Endocrinology, 15, 1508504.
- Expanding the phenotype and genotype spectrum of TAOK1 neurodevelopmental disorder and delineating TAOK2 neurodevelopmental disorder. Genetics in Medicine, 101348-101348.
- Protective effects of miR-24-2-5p in early stages of breast cancer bone metastasis. Breast Cancer Research, 26. View this article in WRRO
- Out with the old (not so!) and in with the new. Journal of Bone Oncology, 100658-100658.
- Clinical Utility of Bone Turnover Markers in Chronic Kidney Disease. Journal of Bone Metabolism, 31(4), 264-278.
- NANOSCALE ZINC-SUBSTITUTED HYDROXYAPATITE: A BONE GRAFTING BIOMATERIAL WITH ENHANCED ANTIBACTERIAL PROPERTIES. Orthopaedic Proceedings, 106-B(SUPP_19), 9-9.
- PREVENTING PERIPROSTHETIC JOINT INFECTION: A NOVEL ANTIMICROBIAL SOL-GEL APPROACH. Orthopaedic Proceedings, 106-B(SUPP_19), 28-28.
- The Pediatric Growth Hormone Deficiency Patient Journey: Identifying Opportunities for Digital Health Interventions.
- Primary cartilage transcriptional signatures reflect cell-type-specific molecular pathways underpinning osteoarthritis. The American Journal of Human Genetics.
- METASTRA: COMPUTER-AIDED EFFECTIVE FRACTURE RISK STRATIFICATION OF PATIENTS WITH VERTEBRAL METASTASES FOR PERSONALIZED TREATMENT THROUGH ROBUST COMPUTATIONAL MODELS VALIDATED IN CLINICAL SETTINGS. Orthopaedic Proceedings, 106-B(SUPP_18), 59-59.
- Evaluación del riesgo de fractura con FRAX y FRAXplus. Gaceta Médica de México, 160(4).
- “I’m quite proud of how we’ve handled it”: health professionals’ experiences of returning additional findings from the 100,000 genomes project. European Journal of Human Genetics, 1-10.
- An expansion of the phenotype in individuals with SYNCRIP-Related Neurodevelopmental Disorder. Rare, 2, 100052-100052.
- An attribution of value framework for combination treatments. Value in Health.
- Discussion paper B, 141-148.
- Opportunities for digitally-enabled personalization and decision support for pediatric growth hormone therapy. Frontiers in Endocrinology, 15. View this article in WRRO
- Correlation of CT measurements of total body gas volume and hounsfield units with post-mortem interval. Indian Journal of Forensic and Community Medicine, 11(3), 111-118.
- Controlled dual drug release from adhesive electrospun patches for prevention and treatment of alveolar osteitis. Journal of Controlled Release, 376, 253-265.
- 8711 The Effect of Testosterone Therapy Upon Bone Remodelling in Testosterone Deficient APOE-/- Mice Fed a High Fat Diet. Journal of the Endocrine Society, 8(Supplement_1).
- 7867 Treatment-related changes in total hip bone mineral density and fracture risk reduction for drugs with different mechanisms of action: the FNIH-ASBMR-SABRE project. Journal of the Endocrine Society, 8(Supplement_1). View this article in WRRO
- 6733 Bone Turnover Markers Predict Bone Mineral Density Increases With Abaloparatide In Men Similarly To Women: Results From ATOM. Journal of the Endocrine Society, 8(Supplement_1).
- Large-scale evaluation of outcomes after a genetic diagnosis in children with severe developmental disorders. Genetics in Medicine Open, 101864-101864.
- Meeting report from the 3rd ISCBH-ERN BOND Achondroplasia Workshop on Long Bone Pathology in Children with Achondroplasia, Salzburg, Austria 22nd June 2024. Bone, 117268-117268.
- Receptor activity-modifying protein modulation of parathyroid hormone-1 receptor function and signaling. Frontiers in Pharmacology, 15. View this article in WRRO
- Pregnancy vitamin D supplementation and offspring bone mineral density in childhood follow-up of a randomized controlled trial. The American Journal of Clinical Nutrition.
- ESR Essentials: imaging of suspected child abuse-practice recommendations by the European Society of Paediatric Radiology.. Eur Radiol.
- The Totality of Evidence for SDZ-deno: A Biosimilar to Reference Denosumab. Clinical Therapeutics.
- The association between selenium status and global and attention-specific cognition in very old adults in the Newcastle 85+ Study: cross-sectional and longitudinal analyses. The American Journal of Clinical Nutrition, S0002-9165(24)00735.
- Losartan alters osteoblast differentiation and increases bone mass through inhibition of TGFB signalling in vitro and in an OIM mouse model. Bone Reports, 22, 101795-101795.
- Data-driven image mechanics (D2IM): A deep learning approach to predict displacement and strain fields from undeformed X-ray tomography images – Evaluation of bone mechanics. Extreme Mechanics Letters, 71, 102202-102202.
- The expression of toll-like receptors in cartilage endplate cells: a role of toll-like receptor 2 in pro-inflammatory and pro-catabolic gene expression. Cells, 13(17). View this article in WRRO
- Sarcopenia definitions and their association with injurious falls in older Swedish women from the Sahlgrenska University Hospital Prospective Evaluation of Risk of Bone fractures (SUPERB) study. Osteoporosis International, 1-10.
- Targeting a STING agonist to perivascular macrophages in prostate tumors delays resistance to androgen deprivation therapy. Journal for ImmunoTherapy of Cancer, 12(7), e009368-e009368.
- Epigenomic differences between osteoarthritis grades in primary cartilage. Osteoarthritis and Cartilage.
- The incidence of fractures in children under two years of age: a systematic review. BMC Musculoskeletal Disorders, 25(1), 528.
- Comprehensive EHMT1 variants analysis broadens genotype-phenotype associations and molecular mechanisms in Kleefstra syndrome. The American Journal of Human Genetics.
- PERI-operative biologic DMARD management: Stoppage or COntinuation during orthoPaEdic operations (the PERISCOPE trial) – a study protocol for a pragmatic, UK multicentre, superiority randomised controlled trial with an internal pilot, economic evaluation and nested qualitative study. BMJ Open, 14(6), e084997-e084997.
- Assessment and management of fracture risk in men with prostate cancer taking androgen deprivation therapy: a retrospective observational primary care database study. British Journal of General Practice, 74(suppl 1), bjgp24X737637-bjgp24X737637.
- The impact of androgen deprivation therapy on bone microarchitecture in men with prostate cancer: A longitudinal observational study (The ANTELOPE Study). Journal of Bone Oncology, 47. View this article in WRRO
- The role of IL-1B in breast cancer bone metastasis. Journal of Bone Oncology, 46, 100608-100608.
- Implications of bone metastasis on response to systemic therapy in patients with advanced renal cell carcinoma: A systematic literature review. Cancer Treatment Reviews, 102792-102792.
- Sialic acid blockade inhibits the metastatic spread of prostate cancer to bone. eBioMedicine, 104, 105163-105163.
- Once-weekly semaglutide versus placebo in adults with increased fracture risk: a randomised, double-blinded, two-centre, phase 2 trial. eClinicalMedicine, 72, 102624-102624.
- Test 1, 1-48.
- Test 2, 49-98.
- Bone mineral density as a surrogate endpoint for fracture risk reduction in clinical trials of osteoporosis therapies: an update on SABRE. The Lancet Diabetes & Endocrinology.
- OA30 Primary osteoarthritis chondrocyte map of chromatin conformation reveals novel effector genes. Rheumatology, 63(Supplement_1).
- Effects of vitamin D3, omega-3s, and a simple strength training exercise program on bone health: the DO-HEALTH randomized controlled trial. Journal of Bone and Mineral Research, 39(6), 661-671.
- Automatic segmentation of lower limb muscles from MR images of post-menopausal women based on deep learning and data augmentation. PLOS ONE, 19(4). View this article in WRRO
- The impact of sedation on the quality of initial skeletal surveys performed for suspected physical abuse in children: a comparative two-centre audit. Clinical Radiology.
- PROFILING METHYLATION IN PRIMARY OSTEOARTHRITIS CARTILAGE. Osteoarthritis and Cartilage, 32, S484-S484.
- The molecular environment of osteoarthritis risk genes in primary cartilage. Osteoarthritis and Cartilage, 32, S475-S476.
- #30. Fractures in metastatic hormone-sensitive prostate cancer (mHSPC). Results from two phase 3 trials from the STAMPEDE platform. Journal of Bone Oncology, 45, 100568-100568.
- BoHFAB. The impact of adjuvant zoledronate therapy on bone health in postmenopausal patients with early breast cancer. Journal of Bone Oncology, 45, 100529-100529.
- #32. Identification of proteins regulating the metastatic spread of breast cancer to bone: Proteomic analysis of the role of the pro-metastatic transcription factor TWIST1 and the gene target micro-RNA (miR-10b). Journal of Bone Oncology, 45, 100570-100570.
- #28. Identification of key proteins within prostate cancer derived exosomes and their role in priming the pre-metastatic niche. Journal of Bone Oncology, 45, 100566-100566.
- PRIMARY OSTEOARTHRITIS CHONDROCYTE MAP OF CHROMATIN CONFORMATION REVEALS NOVEL PUTATIVE EFFECTOR GENES. Osteoarthritis and Cartilage, 32, S467-S468.
- A surrogate FRAX model for Nepal. Archives of Osteoporosis, 19(1), S269-S269.
- Increased primary breast tumor expression of CD73 is associated with development of bone metastases and is a potential biomarker for adjuvant bisphosphonate use. Scientific Reports, 15(1).
- Mapping variants in thyroid hormone transporter MCT8 to disease severity by genomic, phenotypic, functional, structural and deep learning integration. Nature Communications, 16(1).
- Family mapping of previously identified patients with pathogenic or likely pathogenic ALPL variants using predictive genotyping and detailed phenotyping approach: the FAME case–control study. JBMR Plus.
- Fracture Risk Assessment in Metabolic Syndrome in Terms of Secondary Osteoporosis Potential. A Narrative Review. Calcified Tissue International, 116(1).
- Treatment of Osteoporosis and Osteoarthritis in the Oldest Old. Drugs.
- The Effects of Computer Navigation and Patient-Specific Instrumentation on Risk of Revision, PROMs, and Mortality Following Primary TKR. Journal of Bone and Joint Surgery.
- Rheumatoid arthritis and subsequent fracture risk: an individual person meta-analysis to update FRAX. Osteoporosis International.
- Assessment of the benefits of bone modifying agents in the management of advanced breast, prostate, and lung cancers. Current Opinion in Supportive & Palliative Care.
- Nucleus pulposus cell network modelling in the intervertebral disc. npj Systems Biology and Applications, 11(1).
- The Risk of Postoperative Periprosthetic Femoral Fracture After Total Hip Arthroplasty Depends More on Stem Design Than Cement Use. Journal of Bone and Joint Surgery.
- Aarskog-Scott syndrome: a clinical study based on a large series of 111 male patients with a pathogenic variant inFGD1and management recommendations. Journal of Medical Genetics.
- A recap of 2024 and plans for the upcoming year. Pediatric Radiology.
- Conflating the Operational Definition of Osteoporosis with Intervention Thresholds. Calcified Tissue International, 116(1).
- An introduction to Pediatric Radiology’s new section editors (Outside the Americas). Pediatric Radiology.
- Impact of dementia and mild cognitive impairment on bone health in older people. Aging Clinical and Experimental Research, 37(1).
- Standardization of the nomenclature of bone status indices: a milestone in diagnostic consistency and clarity. Osteoporosis International.
- The relationship between baseline BMD and fracture incidence in the placebo groups of RCTs using individual patient data from the FNIH-ASBMR-SABRE Project. Journal of Bone and Mineral Research.
- Estimating net bone formation relative to resorption using reference bone turnover markers. The Journal of Clinical Endocrinology & Metabolism.
- Age at First Fracture and Later Fracture Risk in Older Adults Undergoing Osteoporosis Assessment. JAMA Network Open, 7(12), e2448208-e2448208.
- Guidelines for the correct use of the nomenclature of biochemical indices of bone status: a position statement of the Joint IOF Working Group and IFCC Committee on Bone Metabolism. Clinical Chemistry and Laboratory Medicine (CCLM).
- PCRX-201, a novel IL-1Ra gene therapy treatment approach for low back pain resulting from intervertebral disc degeneration. Gene Therapy.
- Treatment of hypothalamic obesity with GLP-1 analogs. Journal of the Endocrine Society.
- Fabrication of hierarchically porous trabecular bone replicas via 3D printing with high internal phase emulsions (HIPEs). Biofabrication.
- A novel framework for elucidating the effect of mechanical loading on the geometry of ovariectomized mouse tibiae using principal component analysis. Frontiers in Bioengineering and Biotechnology, 12.
- The effects of denosumab on osteoclast precursors in postmenopausal women: a possible explanation for the overshoot phenomenon after discontinuation. Journal of Bone and Mineral Research.
- Targeting the Tumour Antigen 5T4 using CAR-T Cells for the Treatment of Acute Myeloid Leukaemia. Molecular Cancer Therapeutics.
- Cost-effectiveness intervention thresholds for romosozumab and teriparatide in the treatment of osteoporosis in the UK. Osteoporosis International.
- A novel mean shape based post-processing method for enhancing deep learning lower-limb muscle segmentation accuracy. PLOS ONE, 19(10), e0308664-e0308664.
- Fracture Risk Prediction Using the Fracture Risk Assessment Tool in Individuals With Cancer. JAMA Oncology.
- The incidence of postoperative periprosthetic femoral fracture following total hip replacement: An analysis of UK National Joint Registry and Hospital Episodes statistics data. PLOS Medicine, 21(10), e1004462-e1004462.
- Causes of Musculoskeletal Pain in Paget’s Disease of Bone. Calcified Tissue International.
- Extra-osseous Roles of the RANK-RANKL-OPG Axis with a Focus on Skeletal Muscle. Current Osteoporosis Reports.
- Correction: Bermudez-Lekerika et al. Sulfated Hydrogels as Primary Intervertebral Disc Cell Culture Systems. Gels 2024, 10, 330. Gels, 10(10), 612-612.
- 16 Years of learning: the first patient treated with asfotase alfa for perinatal hypophosphatasia. Endocrine Abstracts.
- Insulin resistance, bone health, and fracture risk. Osteoporosis International.
- Proposed Denosumab Biosimilar SB16 vs Reference Denosumab in Postmenopausal Osteoporosis: Phase 3 Results Up to Month 12. The Journal of Clinical Endocrinology & Metabolism.
- Prospects and Current Challenges of Extracellular Vesicle-Based Biomarkers in Cancer. Biology, 13(9), 694-694.
- Effects of High Dose Bolus Cholecalciferol on Free Vitamin D Metabolites, Bone Turnover Markers and Physical Function. Nutrients, 16(17), 2888-2888.
- Natural history of spinal cord compression stage AFMS3 in infants with achondroplasia: retrospective cohort study. Archives of Disease in Childhood.
- Breast Cancer Index in Premenopausal Women With Early-Stage Hormone Receptor–Positive Breast Cancer. JAMA Oncology.
- Implementation of fracture risk assessment in men with prostate cancer requiring long-term androgen deprivation therapy: a systematic scoping review using the i-PARIHS implementation framework. Journal of Cancer Survivorship.
- Children and young people’s preferences and needs when using health technology to self-manage a long-term condition: a scoping review. Archives of Disease in Childhood.
- Clinical utility of the fracture risk assessment tool (FRAX) in biopsy-confirmed coeliac disease. Scandinavian Journal of Gastroenterology, 1-6.
- The relationship between treatment-related changes in total hip bone mineral density measured after 12, 18 and 24 months and fracture risk reduction in osteoporosis clinical trials: the FNIH-ASBMR-SABRE Project. Journal of Bone and Mineral Research.
- Temporary treatment cessation compared with continuation of tyrosine kinase inhibitors for adults with renal cancer: the STAR non-inferiority RCT. Health Technology Assessment, 1-171.
- Goal-Directed Osteoporosis Treatment: ASBMR/BHOF Task Force Position Statement 2024. Journal of Bone and Mineral Research.
- The impact of HIV infection on skeletal maturity in peripubertal children in Zimbabwe: a cross-sectional study. BMC Pediatrics, 24(1).
- Whole genome sequencing refines stratification and therapy of patients with clear cell renal cell carcinoma. Nature Communications, 15(1).
- Evidence for peri-lacunar remodeling and altered osteocyte lacuno-canalicular network in mouse models of myeloma-induced bone disease. JBMR Plus.
- Race-specific FRAX models are evidence-based and support equitable care: a response to the ASBMR Task Force report on Clinical Algorithms for Fracture Risk. Osteoporosis International.
- The potential therapeutic applications of long non-coding RNAs. Journal of Translational Genetics and Genomics, 8(2), 225-43.
- IOF position on scientists and societies operating in conflict zones. Osteoporosis International.
- Predictive value of sarcopenia components for all-cause mortality: findings from population-based cohorts. Aging Clinical and Experimental Research, 36(1).
- Update on fracture risk assessment in osteoporosis. Current Opinion in Endocrinology, Diabetes & Obesity.
- Periprosthetic Joint Infection After Total Knee Arthroplasty With or Without Antibiotic Bone Cement. JAMA Network Open, 7(5), e2412898-e2412898.
- Sulfated Hydrogels as Primary Intervertebral Disc Cell Culture Systems. Gels, 10(5), 330-330.
- Pre-treatment bone mineral density (BMD) and the benefit of pharmacologic treatment on fracture risk and BMD change: analysis from the FNIH-ASBMR SABRE project. Journal of Bone and Mineral Research.
- Impact of the COVID‐19 pandemic on the productivity and career prospects of musculoskeletal researchers. Journal of Orthopaedic Research.
- Supported exercise TrAining for Men wIth prostate caNcer on Androgen deprivation therapy (STAMINA): study protocol for a randomised controlled trial of the clinical and cost-effectiveness of the STAMINA lifestyle intervention compared with optimised usual care, including internal pilot and parallel process evaluation. Trials, 25(1).
- Evaluation of venous thromboembolism risk assessment models for hospital inpatients: the VTEAM evidence synthesis. Health Technology Assessment, 1-166.
- Bisphosphonate alternative regimens for the prevention of osteoporotic fragility fractures: BLAST-OFF, a mixed-methods study. Health Technology Assessment, 1-169.
Chapters
- Bone metastases; clinical aspects, Reference Module in Biomedical Sciences Elsevier
- Understanding Inflicted Injuries in Young Children: Toward an Ontology Based Approach, Lecture Notes in Computer Science (pp. 260-270). Springer Nature Switzerland
- Biochemical markers of bone turnover: age, gender and race as sources of biological variability, Bone Markers (pp. 95-106). CRC Press
- The association between bone turnover and fracture risk (Sheffield Osteoporosis Study), Bone Markers (pp. 225-236). CRC Press
Other
- Supplementary Figure 2 from Targeting Tumor Antigen 5T4 Using CAR T Cells for the Treatment of Acute Myeloid Leukemia.
- Supplementary Table 2 from Targeting Tumor Antigen 5T4 Using CAR T Cells for the Treatment of Acute Myeloid Leukemia.
- Data from Targeting Tumor Antigen 5T4 Using CAR T Cells for the Treatment of Acute Myeloid Leukemia.
- Supplementary Figure 3 from Targeting Tumor Antigen 5T4 Using CAR T Cells for the Treatment of Acute Myeloid Leukemia.
- Supplementary Table 1 from Targeting Tumor Antigen 5T4 Using CAR T Cells for the Treatment of Acute Myeloid Leukemia.
- Supplementary Figure 1 from Targeting Tumor Antigen 5T4 Using CAR T Cells for the Treatment of Acute Myeloid Leukemia.
- Supplementary Figure 4 from Targeting Tumor Antigen 5T4 Using CAR T Cells for the Treatment of Acute Myeloid Leukemia.
Preprints
- Transcriptome regulation analysis in osteoarthritis primary tissues identifies high-confidence effector genes, Cold Spring Harbor Laboratory.
- Nucleus Pulposus Cell Network Modelling in the Intervertebral Disc, Cold Spring Harbor Laboratory.
- The LMSz method - an automatable scalable approach to constructing gene-specific growth charts in rare disorders, Cold Spring Harbor Laboratory.
- Associations of Serum GDF-15 Levels with Physical Performance, Mobility Disability, Cognition, Cardiovascular Disease, and Mortality in Older Adults, Cold Spring Harbor Laboratory.
- Receptor activity modifying protein modulation of parathyroid hormone-1 receptor function and signalling, Cold Spring Harbor Laboratory.
- Targeting of a STING Agonist to Perivascular Macrophages in Prostate Tumors Delays Resistance to Androgen Deprivation Therapy, Cold Spring Harbor Laboratory.