Member Publications
Recent publications from members of the Mellanby Centre.

Publications
Journal articles
- Altered vertebral biomechanical properties in prostate cancer patients following androgen deprivation therapy. Bone, 195, 117465-117465.
- Symmetric normalization algorithm for estimating physiological strain in bones. European Journal of Mechanics - A/Solids, 111, 105539-105539.
- Translational genomics of osteoarthritis in 1,962,069 individuals. Nature.
- Management and mitigation of metabolic bone disease and cardiac adverse events throughout the prostate cancer pathway: clinical review and practical recommendations. Current Medical Research and Opinion.
- SPATIAL TRANSCRIPTOMICS RESOLVES TISSUE-LEVEL MOLECULAR EFFECTS OF DENOSUMAB THERAPY IN A RANDOMIZED CLINICAL TRIAL FOR PERIPROSTHETIC OSTEOLYSIS. Orthopaedic Proceedings, 107-B(SUPP_2), 48-48.
- THE ASSOCIATION BETWEEN IMPLANT DESIGN, AGE, SEX, AND THE RATE OF MAJOR REOPERATION IN PATIENTS UNDERGOING PRIMARY TOTAL HIP ARTHROPLASTY: AN ANALYSIS OF UK NATIONAL JOINT REGISTRY AND HOSPITAL EPISODE STATISTICS DATA. Orthopaedic Proceedings, 107-B(SUPP_2), 47-47.
- Mobility and quality of life in adults with paediatric-onset hypophosphatasia treated with Asfotase alfa: results from UK managed access agreement. Advances in Therapy. View this article in WRRO
- On-call or not on-call, what difference does it make in paediatric radiology?. Insights into Imaging, 16(1), 73.
- Application and validation of semiautomatic quantification of immunohistochemically stained sections for low cellular tissue such as intervertebral disc using QuPath. JOR Spine, 8(1). View this article in WRRO
- In children under two years of age, does the bone health index value differ between those with and without osteogenesis imperfecta?. Bone, 117467-117467.
- Executive Summary: Treatment of Osteoporosis and Osteoarthritis in the Oldest Old. Drugs & Aging, 42(3), 179-181.
- Expanding the Phenotypic Spectrum of HNRNPU-Related Disorder, Documenting the First Familial Presentation and Comprehensive Review.. Am J Med Genet A, e64013.
- A surrogate FRAX model for Mongolia. Archives of Osteoporosis, 20(1), 27.
- Ex Vivo and In Vitro Proteomic Approach to Elucidate the Relevance of IL-4 and IL-10 in Intervertebral Disc Pathophysiology.. JOR Spine, 8(1), e70048.
- A Cryptic
CBFB Deletion–Inversion Expands the Mutational Spectrum of Variants Associated With Cleidocranial Dysplasia. Clinical Genetics. - Explorative Study of Modulatory Effects of Notochordal Cell‐Derived Extracellular Vesicles on the
IL ‐1β‐Induced Catabolic Cascade in Nucleus Pulposus Cell Pellets and Explants. JOR SPINE, 8(1). - Assessing and Managing Primary Hyperparathyroidism and Fracture Risk in England: A Survey of Medical Professionals. Journal of the Endocrine Society, 9(2).
- The publication fate of abstracts awarded prizes at European Society of Paediatric Radiology annual scientific meetings. Pediatric Radiology.
- Degeneration of the nucleus pulposus affects the internal volumetric strains and failure location of adjacent human metastatic vertebral bodies. Acta Biomaterialia, 194, 258-269. View this article in WRRO
- Bone Turnover Markers Predict Changes in Bone Mineral Density in Men Treated with Abaloparatide: Results from ATOM.. J Bone Miner Res.
- Assessment of fracture risk with FRAX and FRAXplus. Gaceta Médica de México, 160(4).
- Microstructure of the human metastatic vertebral body. Frontiers in Endocrinology, 15. View this article in WRRO
- P263: HNRNP-related neurodevelopmental disorders: Expanding knowledge of known conditions and prompting novel studies into candidate genes. Genetics in Medicine Open, 3, 102228-102228.
- Which paediatric fractures lack research evidence regarding their diagnosis using artificial intelligence? A systematic review. The Royal College of Radiologists Open, 3, 100165-100165.
- Assessing the performance of a deep learning algorithm for detection of scaphoid fractures in paediatric radiographs. The Royal College of Radiologists Open, 3, 100202-100202.
- In-silico proteomic analysis of the role of IL-4 and IL-10 in IVD degeneration: Protein-protein interaction networks for candidate prioritisation. Computational and Structural Biotechnology Journal, 27, 1600-1613.
- Long term health outcomes in people with diabetes 12 months after hospitalisation with COVID-19 in the UK: a prospective cohort study. eClinicalMedicine, 79. View this article in WRRO
- SB16 versus reference denosumab in postmenopausal women with osteoporosis: 18-month outcomes of a phase III randomized clinical trial. Bone, 192, 117371-117371.
- Rapid assessment of the osteogenic capacity of hydroxyapatite/aragonite using a murine tibial periosteal ossification model. Bioactive Materials, 45, 257-273.
- Expanding the phenotype and genotype spectrum of TAOK1 neurodevelopmental disorder and delineating TAOK2 neurodevelopmental disorder. Genetics in Medicine, 101348-101348.
- Protective effects of miR-24-2-5p in early stages of breast cancer bone metastasis. Breast Cancer Research, 26. View this article in WRRO
- Out with the old (not so!) and in with the new. Journal of Bone Oncology, 100658-100658.
- Clinical Utility of Bone Turnover Markers in Chronic Kidney Disease. Journal of Bone Metabolism, 31(4), 264-278.
- NANOSCALE ZINC-SUBSTITUTED HYDROXYAPATITE: A BONE GRAFTING BIOMATERIAL WITH ENHANCED ANTIBACTERIAL PROPERTIES. Orthopaedic Proceedings, 106-B(SUPP_19), 9-9.
- PREVENTING PERIPROSTHETIC JOINT INFECTION: A NOVEL ANTIMICROBIAL SOL-GEL APPROACH. Orthopaedic Proceedings, 106-B(SUPP_19), 28-28.
- The Pediatric Growth Hormone Deficiency Patient Journey: Identifying Opportunities for Digital Health Interventions.
- Primary cartilage transcriptional signatures reflect cell-type-specific molecular pathways underpinning osteoarthritis. The American Journal of Human Genetics.
- METASTRA: COMPUTER-AIDED EFFECTIVE FRACTURE RISK STRATIFICATION OF PATIENTS WITH VERTEBRAL METASTASES FOR PERSONALIZED TREATMENT THROUGH ROBUST COMPUTATIONAL MODELS VALIDATED IN CLINICAL SETTINGS. Orthopaedic Proceedings, 106-B(SUPP_18), 59-59.
- Evaluación del riesgo de fractura con FRAX y FRAXplus. Gaceta Médica de México, 160(4).
- “I’m quite proud of how we’ve handled it”: health professionals’ experiences of returning additional findings from the 100,000 genomes project. European Journal of Human Genetics, 1-10.
- An expansion of the phenotype in individuals with SYNCRIP-Related Neurodevelopmental Disorder. Rare, 2, 100052-100052.
- An attribution of value framework for combination treatments. Value in Health.
- Discussion paper B, 141-148.
- Opportunities for digitally-enabled personalization and decision support for pediatric growth hormone therapy. Frontiers in Endocrinology, 15. View this article in WRRO
- Correlation of CT measurements of total body gas volume and hounsfield units with post-mortem interval. Indian Journal of Forensic and Community Medicine, 11(3), 111-118.
- Controlled dual drug release from adhesive electrospun patches for prevention and treatment of alveolar osteitis. Journal of Controlled Release, 376, 253-265.
- 8711 The Effect of Testosterone Therapy Upon Bone Remodelling in Testosterone Deficient APOE-/- Mice Fed a High Fat Diet. Journal of the Endocrine Society, 8(Supplement_1).
- 7867 Treatment-Related Changes in Total Hip Bone Mineral Density and Fracture Risk Reduction for Drugs With Different Mechanisms of Action: The FNIH-ASBMR-SABRE Project. Journal of the Endocrine Society, 8(Supplement_1).
- 6733 Bone Turnover Markers Predict Bone Mineral Density Increases With Abaloparatide In Men Similarly To Women: Results From ATOM. Journal of the Endocrine Society, 8(Supplement_1).
- A novel mean shape based post-processing method for enhancing deep learning lower-limb muscle segmentation accuracy. PLOS ONE, 19(10). View this article in WRRO
- Large-scale evaluation of outcomes after a genetic diagnosis in children with severe developmental disorders. Genetics in Medicine Open, 101864-101864.
- Meeting report from the 3rd ISCBH-ERN BOND Achondroplasia Workshop on Long Bone Pathology in Children with Achondroplasia, Salzburg, Austria 22nd June 2024. Bone, 117268-117268.
- Receptor activity-modifying protein modulation of parathyroid hormone-1 receptor function and signaling. Frontiers in Pharmacology, 15. View this article in WRRO
- Pregnancy vitamin D supplementation and offspring bone mineral density in childhood follow-up of a randomized controlled trial. The American Journal of Clinical Nutrition, 120(5), 1134-1142.
- ESR Essentials: imaging of suspected child abuse-practice recommendations by the European Society of Paediatric Radiology.. Eur Radiol.
- The Totality of Evidence for SDZ-deno: A Biosimilar to Reference Denosumab. Clinical Therapeutics.
- The association between selenium status and global and attention-specific cognition in very old adults in the Newcastle 85+ Study: cross-sectional and longitudinal analyses. The American Journal of Clinical Nutrition, S0002-9165(24)00735.
- Data-driven image mechanics (D2IM): A deep learning approach to predict displacement and strain fields from undeformed X-ray tomography images – Evaluation of bone mechanics. Extreme Mechanics Letters, 71, 102202-102202.
- The expression of toll-like receptors in cartilage endplate cells: a role of toll-like receptor 2 in pro-inflammatory and pro-catabolic gene expression. Cells, 13(17). View this article in WRRO
- Sarcopenia definitions and their association with injurious falls in older Swedish women from the Sahlgrenska University Hospital Prospective Evaluation of Risk of Bone fractures (SUPERB) study. Osteoporosis International, 1-10.
- Losartan alters osteoblast differentiation and increases bone mass through inhibition of TGFB signalling in vitro and in an OIM mouse model. Bone Reports, 22. View this article in WRRO
- Targeting a STING agonist to perivascular macrophages in prostate tumors delays resistance to androgen deprivation therapy. Journal for ImmunoTherapy of Cancer, 12(7), e009368-e009368.
- Epigenomic differences between osteoarthritis grades in primary cartilage. Osteoarthritis and Cartilage.
- The incidence of fractures in children under two years of age: a systematic review. BMC Musculoskeletal Disorders, 25(1), 528.
- Comprehensive EHMT1 variants analysis broadens genotype-phenotype associations and molecular mechanisms in Kleefstra syndrome. The American Journal of Human Genetics.
- PERI-operative biologic DMARD management: Stoppage or COntinuation during orthoPaEdic operations (the PERISCOPE trial) – a study protocol for a pragmatic, UK multicentre, superiority randomised controlled trial with an internal pilot, economic evaluation and nested qualitative study. BMJ Open, 14(6), e084997-e084997.
- Assessment and management of fracture risk in men with prostate cancer taking androgen deprivation therapy: a retrospective observational primary care database study. British Journal of General Practice, 74(suppl 1), bjgp24X737637-bjgp24X737637.
- The impact of androgen deprivation therapy on bone microarchitecture in men with prostate cancer: A longitudinal observational study (The ANTELOPE Study). Journal of Bone Oncology, 47. View this article in WRRO
- The role of IL-1B in breast cancer bone metastasis. Journal of Bone Oncology, 46, 100608-100608.
- Implications of bone metastasis on response to systemic therapy in patients with advanced renal cell carcinoma: A systematic literature review. Cancer Treatment Reviews, 102792-102792.
- Sialic acid blockade inhibits the metastatic spread of prostate cancer to bone. eBioMedicine, 104, 105163-105163.
- Once-weekly semaglutide versus placebo in adults with increased fracture risk: a randomised, double-blinded, two-centre, phase 2 trial. eClinicalMedicine, 72, 102624-102624.
- Test 1, 1-48.
- Test 2, 49-98.
- A surrogate FRAX model for Nepal. Archives of Osteoporosis, 19(1), S269-S269.
- An oncolytic adenovirus targeting SLAMF7 demonstrates anti-myeloma efficacy. Leukemia, 1-15.
- Update on the role of bone turnover markers in the diagnosis and management of osteoporosis: a consensus paper from The European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO), International Osteoporosis Foundation (IOF), and International Federation of Clinical Chemistry and Laboratory Medicine (IFCC). Osteoporosis International.
- Increased primary breast tumor expression of CD73 is associated with development of bone metastases and is a potential biomarker for adjuvant bisphosphonate use. Scientific Reports, 15(1).
- Mapping variants in thyroid hormone transporter MCT8 to disease severity by genomic, phenotypic, functional, structural and deep learning integration. Nature Communications, 16(1).
- Family mapping of previously identified patients with pathogenic or likely pathogenic ALPL variants using predictive genotyping and detailed phenotyping approach: the FAME case–control study. JBMR Plus.
- Fracture Risk Assessment in Metabolic Syndrome in Terms of Secondary Osteoporosis Potential. A Narrative Review. Calcified Tissue International, 116(1).
- Treatment of Osteoporosis and Osteoarthritis in the Oldest Old. Drugs.
- The Effects of Computer Navigation and Patient-Specific Instrumentation on Risk of Revision, PROMs, and Mortality Following Primary TKR. Journal of Bone and Joint Surgery.
- Rheumatoid arthritis and subsequent fracture risk: an individual person meta-analysis to update FRAX. Osteoporosis International.
- Assessment of the benefits of bone modifying agents in the management of advanced breast, prostate, and lung cancers. Current Opinion in Supportive & Palliative Care.
- Nucleus pulposus cell network modelling in the intervertebral disc. npj Systems Biology and Applications, 11(1).
- The Risk of Postoperative Periprosthetic Femoral Fracture After Total Hip Arthroplasty Depends More on Stem Design Than Cement Use. Journal of Bone and Joint Surgery.
- Aarskog-Scott syndrome: a clinical study based on a large series of 111 male patients with a pathogenic variant inFGD1and management recommendations. Journal of Medical Genetics.
- A recap of 2024 and plans for the upcoming year. Pediatric Radiology.
- Conflating the Operational Definition of Osteoporosis with Intervention Thresholds. Calcified Tissue International, 116(1).
- An introduction to Pediatric Radiology’s new section editors (Outside the Americas). Pediatric Radiology.
- Impact of dementia and mild cognitive impairment on bone health in older people. Aging Clinical and Experimental Research, 37(1).
- Standardization of the nomenclature of bone status indices: a milestone in diagnostic consistency and clarity. Osteoporosis International.
- The relationship between baseline BMD and fracture incidence in the placebo groups of RCTs using individual patient data from the FNIH-ASBMR-SABRE Project. Journal of Bone and Mineral Research.
- Estimating net bone formation relative to resorption using reference bone turnover markers. The Journal of Clinical Endocrinology & Metabolism.
- Age at First Fracture and Later Fracture Risk in Older Adults Undergoing Osteoporosis Assessment. JAMA Network Open, 7(12), e2448208-e2448208.
- Guidelines for the correct use of the nomenclature of biochemical indices of bone status: a position statement of the Joint IOF Working Group and IFCC Committee on Bone Metabolism. Clinical Chemistry and Laboratory Medicine (CCLM).
- PCRX-201, a novel IL-1Ra gene therapy treatment approach for low back pain resulting from intervertebral disc degeneration. Gene Therapy.
- Treatment of hypothalamic obesity with GLP-1 analogs. Journal of the Endocrine Society.
- Fabrication of hierarchically porous trabecular bone replicas via 3D printing with high internal phase emulsions (HIPEs). Biofabrication.
- A novel framework for elucidating the effect of mechanical loading on the geometry of ovariectomized mouse tibiae using principal component analysis. Frontiers in Bioengineering and Biotechnology, 12.
- The effects of denosumab on osteoclast precursors in postmenopausal women: a possible explanation for the overshoot phenomenon after discontinuation. Journal of Bone and Mineral Research.
- Targeting the Tumour Antigen 5T4 using CAR-T Cells for the Treatment of Acute Myeloid Leukaemia. Molecular Cancer Therapeutics.
- Cost-effectiveness intervention thresholds for romosozumab and teriparatide in the treatment of osteoporosis in the UK. Osteoporosis International.
- Fracture Risk Prediction Using the Fracture Risk Assessment Tool in Individuals With Cancer. JAMA Oncology.
- The incidence of postoperative periprosthetic femoral fracture following total hip replacement: An analysis of UK National Joint Registry and Hospital Episodes statistics data. PLOS Medicine, 21(10), e1004462-e1004462.
- Causes of Musculoskeletal Pain in Paget’s Disease of Bone. Calcified Tissue International.
- Extra-osseous Roles of the RANK-RANKL-OPG Axis with a Focus on Skeletal Muscle. Current Osteoporosis Reports.
- Correction: Bermudez-Lekerika et al. Sulfated Hydrogels as Primary Intervertebral Disc Cell Culture Systems. Gels 2024, 10, 330. Gels, 10(10), 612-612.
- 16 Years of learning: the first patient treated with asfotase alfa for perinatal hypophosphatasia. Endocrine Abstracts.
- Insulin resistance, bone health, and fracture risk. Osteoporosis International.
- Proposed Denosumab Biosimilar SB16 vs Reference Denosumab in Postmenopausal Osteoporosis: Phase 3 Results Up to Month 12. The Journal of Clinical Endocrinology & Metabolism.
- Prospects and Current Challenges of Extracellular Vesicle-Based Biomarkers in Cancer. Biology, 13(9), 694-694.
- Effects of High Dose Bolus Cholecalciferol on Free Vitamin D Metabolites, Bone Turnover Markers and Physical Function. Nutrients, 16(17), 2888-2888.
- Natural history of spinal cord compression stage AFMS3 in infants with achondroplasia: retrospective cohort study. Archives of Disease in Childhood.
- Breast Cancer Index in Premenopausal Women With Early-Stage Hormone Receptor–Positive Breast Cancer. JAMA Oncology.
- Implementation of fracture risk assessment in men with prostate cancer requiring long-term androgen deprivation therapy: a systematic scoping review using the i-PARIHS implementation framework. Journal of Cancer Survivorship.
- Children and young people’s preferences and needs when using health technology to self-manage a long-term condition: a scoping review. Archives of Disease in Childhood.
- Clinical utility of the fracture risk assessment tool (FRAX) in biopsy-confirmed coeliac disease. Scandinavian Journal of Gastroenterology, 1-6.
- The relationship between treatment-related changes in total hip bone mineral density measured after 12, 18 and 24 months and fracture risk reduction in osteoporosis clinical trials: the FNIH-ASBMR-SABRE Project. Journal of Bone and Mineral Research.
- Temporary treatment cessation compared with continuation of tyrosine kinase inhibitors for adults with renal cancer: the STAR non-inferiority RCT. Health Technology Assessment, 1-171.
- Goal-Directed Osteoporosis Treatment: ASBMR/BHOF Task Force Position Statement 2024. Journal of Bone and Mineral Research.
- The impact of HIV infection on skeletal maturity in peripubertal children in Zimbabwe: a cross-sectional study. BMC Pediatrics, 24(1).
- Whole genome sequencing refines stratification and therapy of patients with clear cell renal cell carcinoma. Nature Communications, 15(1).
- Evidence for peri-lacunar remodeling and altered osteocyte lacuno-canalicular network in mouse models of myeloma-induced bone disease. JBMR Plus.
- Race-specific FRAX models are evidence-based and support equitable care: a response to the ASBMR Task Force report on Clinical Algorithms for Fracture Risk. Osteoporosis International.
- The potential therapeutic applications of long non-coding RNAs. Journal of Translational Genetics and Genomics, 8(2), 225-43.
- IOF position on scientists and societies operating in conflict zones. Osteoporosis International.
- Predictive value of sarcopenia components for all-cause mortality: findings from population-based cohorts. Aging Clinical and Experimental Research, 36(1).
- Update on fracture risk assessment in osteoporosis. Current Opinion in Endocrinology, Diabetes & Obesity.
- Periprosthetic Joint Infection After Total Knee Arthroplasty With or Without Antibiotic Bone Cement. JAMA Network Open, 7(5), e2412898-e2412898.
- Sulfated Hydrogels as Primary Intervertebral Disc Cell Culture Systems. Gels, 10(5), 330-330.
- Pre-treatment bone mineral density (BMD) and the benefit of pharmacologic treatment on fracture risk and BMD change: analysis from the FNIH-ASBMR SABRE project. Journal of Bone and Mineral Research.
- Impact of the COVID‐19 pandemic on the productivity and career prospects of musculoskeletal researchers. Journal of Orthopaedic Research.
Chapters
- Bone metastases; clinical aspects, Reference Module in Biomedical Sciences Elsevier
- Understanding Inflicted Injuries in Young Children: Toward an Ontology Based Approach, Lecture Notes in Computer Science (pp. 260-270). Springer Nature Switzerland
- Biochemical markers of bone turnover: age, gender and race as sources of biological variability, Bone Markers (pp. 95-106). CRC Press
- The association between bone turnover and fracture risk (Sheffield Osteoporosis Study), Bone Markers (pp. 225-236). CRC Press
Other
- Supplementary Figure 2 from Targeting Tumor Antigen 5T4 Using CAR T Cells for the Treatment of Acute Myeloid Leukemia.
- Supplementary Table 2 from Targeting Tumor Antigen 5T4 Using CAR T Cells for the Treatment of Acute Myeloid Leukemia.
- Data from Targeting Tumor Antigen 5T4 Using CAR T Cells for the Treatment of Acute Myeloid Leukemia.
- Supplementary Figure 3 from Targeting Tumor Antigen 5T4 Using CAR T Cells for the Treatment of Acute Myeloid Leukemia.
- Supplementary Table 1 from Targeting Tumor Antigen 5T4 Using CAR T Cells for the Treatment of Acute Myeloid Leukemia.
- Supplementary Figure 1 from Targeting Tumor Antigen 5T4 Using CAR T Cells for the Treatment of Acute Myeloid Leukemia.
- Supplementary Figure 4 from Targeting Tumor Antigen 5T4 Using CAR T Cells for the Treatment of Acute Myeloid Leukemia.
Preprints
- Transcriptome regulation analysis in osteoarthritis primary tissues identifies high-confidence effector genes, Cold Spring Harbor Laboratory.
- Nucleus Pulposus Cell Network Modelling in the Intervertebral Disc, Cold Spring Harbor Laboratory.
- The LMSz method - an automatable scalable approach to constructing gene-specific growth charts in rare disorders, Cold Spring Harbor Laboratory.
- Associations of Serum GDF-15 Levels with Physical Performance, Mobility Disability, Cognition, Cardiovascular Disease, and Mortality in Older Adults, Cold Spring Harbor Laboratory.