biOMICS Mass Spectrometry Instruments

Welcome to the biOMICS Mass Spectrometry Facility!
Our facility partners with University researchers and external collaborators, providing them with advanced mass spectrometry solutions through our state-of-the-art instrumentation and specialised expertise.

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Capabilities

We apply various proteomics and metabolomics strategies to address and answer your research questions. We also host state-of-the-art infrastructure for identification, characterisation and quantitation of small to large biological molecules using advanced mass spectrometry based approaches.

Proteomics

Protein identification, quantification and characterisation

Proteome profiling
Protein-protein interactions
Post-translational modifications
Biomarker discovery
Relative and absolute quantitation
Multiplexing quantitation

Metabolomics

Metabolite identification, quantification and characterisation

Plant metabolism studies
Drug metabolism studies
Metabolic disorders
Biomarker discovery
Cell development stage

Mass spec imaging

MALDI/DESI imaging

Isotope ratio analysis

Stable carbon and nitrogen isotope ratio measurement
Isotopic labelling tracer studies

Instruments

Mass Spectrometry (MS)

> Bruker tims TOF fleX MALDI-2

Tims-Tof-Maldi2	MALDI-MS-imaging down to 5 µm spatial resolution UPLC-MS targeted analysis Non-targeted metabolic profiling MS/MS and TIMS analysis of ions for mass identification Rapid DDA and DIA-PASEF (ion mobility enabled) proteomic analysis

> Thermo Orbitrap Exploris 480

Shotgun proteomics/peptide characterisation
High resolution reporter ion quantification (TMT)
SureQuant (internal standard triggered targeted quantification of peptides/proteins
Absolute or relative quantitation through methodologies such as AQUA, SILAC, LFQ (label-free quantification), isobaric tags (TMT, iTRAQ)
Post-translational modifications of proteins such as phosphorylation, acetylation, methylation and ubiquitination

> Waters G2/G2Si Synapt