Professor Sheila MacNeil
BSc (Hons), PhD
School of Chemical, Materials and Biological Engineering
Emeritus Professor
Professor of Biomaterials and Tissue Engineering
- Profile
-
Sheila is Emeritus Professor of Tissue Engineering with expertise in tissue engineering of soft tissues (skin, oral mucosa, urethra and cornea) with a focus on translating research to the clinic. She has over 550 peer-reviewed articles and an h-index of 57.
Since 1992 she has worked with clinicians in Sheffield, delivering autologous keratinocytes to burns patients and developed and commercialised improved delivery of skin cells to patients with MySkin™ and Cryoskin™ (autologous and allogeneic cell therapy for wound healing). In the last decade she has focussed on three translational project areas. The first with NHS Urologist Professor Chris Chapple in Sheffield to develop tissue engineered oral mucosa for reconstruction of urethral strictures and to develop alternative materials for support of the weakened tissues of the pelvic floor. The second project is developing cell delivery membranes for corneal defects working with colleagues in India. The third project is developing novel biomaterials to promote angiogenesis in chronic wounds working with Dr Muhammed Yar in Pakistan.
The research collaboration with India has led to a simplification in the treatment of corneal scarring which has reduced the cost by 90% and most importantly increased accessibility of this technique to patients. This has led to a change in clinical practice in India and has attracted considerable publicity.
She received the UK Society of Biomaterials President’s medal for her contributions to Biomaterials in both the UK and overseas in September 2014 and the Institute of Materials, Minerals and Mining (IOM3) Chapman Medal for Biomedical Materials and Biomaterials Innovation in 2018.
Sheila retired in September 2018 but remains research active.
- Qualifications
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BSc (Hons) Physiology, Aberdeen University 1972
PhD, Physiology, Sheffield University 1976
- Research interests
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Sheila’s research currently spans four interdisciplinary themes:
- 3D in vitro models of skin, oral mucosa, cornea and vagina
The group has a 20 year history of developing 3D models of soft tissue to look at a range of problems including wound healing, angiogenesis and bacterial infection. The skin model is currently used to study skin contraction in adult and paediatric burns patients using autologous fat. - Developing cell delivery membranes for corneal defects working with colleagues in India
The most recent outcome of this research has led to a significant improvement in how patients receive treatment for corneal scarring – the new simplified technique is more accessible to more patients and only costs 10% of the previous technique. News story. - Developing alternative materials for support of the weakened tissues of the pelvic floor
This project has led to patented technology now licenced to a spin out company Symimetics. Work is ongoing to develop material into a device for a first in women study for the surgical treatment of stress urinary incontinence. - Developing novel biomaterials to promote angiogenesis in chronic wounds
Working with Dr Muhammed Yar in Pakistan to deliver a 2dDRribose sugar capable of inducing angiogenesis and promoting wound healing.
- 3D in vitro models of skin, oral mucosa, cornea and vagina
- Publications
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Edited books
- Cellular In Vitro Testing: Methods and Protocols. Singapore: Pan Stanford Publishing.
Journal articles
- 25 Novel biomaterials for stress urinary incontinence: development of a clinically relevant large animal model to mimic suburethral implantation. European Urology Open Science, 71, S28-S29.
- Exploring interspecies differences in ex vivo models of Pseudomonas aeruginosa keratitis: a comparative study of human, pig and sheep corneas. Journal of Medical Microbiology, 73(12).
- Evidence of time dependent degradation of polypropylene surgical mesh explanted from the abdomen and vagina of sheep.. Journal of the Mechanical Behavior of Biomedical Materials, 106722-106722.
- Strengthening preclinical testing to increase safety in surgical mesh. Nature Reviews Urology. View this article in WRRO
- Uncovering the relationship between macrophages and polypropylene surgical mesh. Biomaterials Advances, 159. View this article in WRRO
- An alginate-Based tube gel delivering 2-deoxy-D-ribose for stimulation of wound healing. Journal of Biomaterials Applications, 38(2), 264-279.
- Tetraspanin CD9-derived peptides inhibits Pseudomonas aeruginosa corneal infection and aids in wound healing of corneal epithelial cells. The Ocular Surface.
- Estradiol-17β [E2] stimulates wound healing in a 3D in vitro tissue-engineered vaginal wound model. Journal of Tissue Engineering, 14, 204173142211492-204173142211492.
- Selectively inhibiting malignant melanoma migration and invasion in an engineered skin model using actin-targeting dinuclear Ru-II-complexes. RSC Medicinal Chemistry.
- Early treatment of corneal abrasions and ulcers–estimating clinical and economic outcomes. The Lancet Regional Health - Southeast Asia, 100038-100038.
- Assessing the immunosuppressive activity of alginate-encapsulated mesenchymal stromal cells on splenocytes. Artificial Cells, Nanomedicine, and Biotechnology, 50(1), 168-176.
- Generation and use of functionalised hydrogels that can rapidly sample infected surfaces. MethodsX, 9.
- A novel characterisation approach to reveal the mechano–chemical effects of oxidation and dynamic distension on polypropylene surgical mesh. RSC Advances, 11(55), 34710-34723. View this article in WRRO
- Developing wound dressings using 2-deoxy-D-Ribose to induce angiogenesis as a backdoor route for stimulating the production of vascular endothelial growth factor. International Journal of Molecular Sciences, 22(21).
- Proof-of-concept study of electrospun PLGA membrane in the treatment of limbal stem cell deficiency. BMJ Open Ophthalmology, 6(1), e000762-e000762.
- Simulation of the process of angiogenesis: Quantification and assessment of vascular patterning in the chicken chorioallantoic membrane. Computers in Biology and Medicine, 136, 104647-104647.
- Development of a novel micro-bead force spectroscopy approach to measure the ability of a thermo-active polymer to remove bacteria from a corneal model. Scientific Reports, 11(1).
- The use of microfabrication techniques for the design and manufacture of artificial stem cell microenvironments for tissue regeneration.. Bioengineering (Basel), 8(5). View this article in WRRO
- Fabrication of Topographically Controlled Electrospun Scaffolds to Mimic the Stem Cell Microenvironment in the Dermal-Epidermal Junction.. ACS Biomater Sci Eng.
- Semi-interpenetrating Polyurethane Network Foams Containing Highly Branched Poly( N -isopropyl acrylamide) with Vancomycin Functionality. ACS Applied Bio Materials.
- Economic, clinical and social impact of simple limbal epithelial transplantation for limbal stem cell deficiency.. Br J Ophthalmol.
- Branched amphotericin functional poly(
N
-
iso
propyl acrylamide): an antifungal polymer. Royal Society Open Science, 8(1), 201655-201655.
- Decellularised extracellular matrix decorated PCL PolyHIPE scaffolds for enhanced cellular activity, integration and angiogenesis. Biomaterials Science.
- Corneal infection models : tools to investigate the role of biofilms in bacterial keratitis. Cells, 9(11). View this article in WRRO
- Re: Landmarks in Vaginal Mesh Development: Polypropylene Mesh for Treatment of SUI and POP. Journal of Urology, 204(4), 884-884.
- Identification of a fibrin concentration that promotes skin cell outgrowth from skin explants onto a synthetic dermal substitute. JPRAS Open, 25, 8-17. View this article in WRRO
- Effect of High-dose Ascorbic Acid on Prostate Cancer Cells and Angiogenesis. The Bulletin of Urooncology, 19(3), 107-111.
- Bioengineered airway epithelial grafts with mucociliary function based on collagen IV- and laminin-containing extracellular matrix scaffolds. European Respiratory Journal, 55(6). View this article in WRRO
- 2-deoxy-d-ribose (2dDR) upregulates vascular endothelial growth factor (VEGF) and stimulates angiogenesis. Microvascular Research, 131, 104035-104035.
- Developing affordable and accessible pro‐angiogenic wound dressings; incorporation of 2 deoxy D‐ribose (2dDR) into cotton fibres and wax‐coated cotton fibres. Journal of Tissue Engineering and Regenerative Medicine. View this article in WRRO
- Establishing a porcine ex vivo cornea model for studying drug treatments against bacterial keratitis. Journal of Visualized Experiments. View this article in WRRO
- Bioengineering vascular networks to study angiogenesis and vascularisation of physiologically relevant tissue models in vitro. ACS Biomaterials Science & Engineering. View this article in WRRO
- Multifunctional copper-containing mesoporous glass nanoparticles as antibacterial and proangiogenic agents for chronic wounds. Frontiers in Bioengineering and Biotechnology, 8. View this article in WRRO
- A dinuclear ruthenium(II) complex excited by near-infrared light through two-photon absorption induces phototoxicity deep within hypoxic regions of melanoma cancer spheroids. Journal of the American Chemical Society. View this article in WRRO
- Characterization of ocular clinical isolates of Pseudomonas aeruginosa from non-contact lens related keratitis patients from south India. Microorganisms, 8(2). View this article in WRRO
- Hydrophobicity modulated antibacterial small molecule eradicates biofilm with potent efficacy against skin-infections. ACS Infectious Diseases. View this article in WRRO
- Regenerative medicine and injection therapies in stress urinary incontinence. Nature Reviews Urology, 17(3), 151-161.
- Assessment of the angiogenic potential of 2-deoxy-D-ribose using a novel in vitro 3D dynamic model in comparison with established in vitro assays. Frontiers in Bioengineering and Biotechnology, 7. View this article in WRRO
- Assessment of Electrospun and Ultra-lightweight Polypropylene Meshes in the Sheep Model for Vaginal Surgery. European Urology Focus, 6(1), 190-198.
- Pre-Seeding of Simple Electrospun Scaffolds with a Combination of Endothelial Cells and Fibroblasts Strongly Promotes Angiogenesis. Tissue Engineering and Regenerative Medicine, 17(4), 445-458.
- Landmarks in vaginal mesh development: polypropylene mesh for treatment of SUI and POP. Nature Reviews Urology, 16(11), 675-689. View this article in WRRO
- Ag modified mesoporous bioactive glass nanoparticles for enhanced antibacterial activity in 3D infected skin model. Materials Science and Engineering: C, 103. View this article in WRRO
- A novel bilayer polycaprolactone membrane for guided bone regeneration : combining electrospinning and emulsion templating. Materials, 12(16), 2643-2643. View this article in WRRO
- Cutting corners, or simplifying technology to reach more patients; using the body as its own incubator for epithelial regeneration. Indian Journal of Ophthalmology, 67(8), 1261-1261.
- Decellularised baby spinach leaves and their potential use in tissue engineering applications: Studying and promoting neovascularisation. Journal of Biomaterials Applications, 34(4), 546-559.
- Editorial introductions. Current Opinion in Urology, 29(4), v-vi.
- Addition of 2-deoxy-d-ribose to clinically used alginate dressings stimulates angiogenesis and accelerates wound healing in diabetic rats. Journal of Biomaterials Applications, 34(4), 463-475.
- Editorial: What we know, what we don't know and what we need to know.. Curr Opin Urol, 29(4), 378-379.
- Using ex Ovo Chick Chorioallantoic Membrane (CAM) Assay To Evaluate the Biocompatibility and Angiogenic Response to Biomaterials. ACS Biomaterials Science & Engineering, 5(7), 3190-3200.
- Incidence and management of cleft lip and palate in Pakistan. Journal of the Pakistan Medical Association, 69(5), 632-639.
- Editorial. Current Opinion in Urology, 29(4), 378-379.
- The changing regulatory landscape for biomedical implants and its relationship to withdrawal of some vaginal mesh products. Current Opinion in Urology, 29(4), 414-418.
- Improving the biocompatibility of biomaterial constructs and constructs delivering cells for the pelvic floor. Current Opinion in Urology, 29(4), 419-425.
- Tissue engineering for the pelvic floor. Current Opinion in Urology, 29(4), 426-430.
- Designing new synthetic materials for use in the pelvic floor. Current Opinion in Urology, 29(4), 407-413.
- Corrigendum to “Overcoming scarring in the urethra: Challenges for tissue engineering”. Asian Journal of Urology, 6(2), 215-215.
- An estradiol releasing, proangiogenic hydrogel as a candidate material for use in soft tissue interposition. Neurourology and Urodynamics, 38(5), 1195-1202.
- The use of implanted materials for treating women with pelvic organ prolapse and stress urinary incontinence. Current Opinion in Urology, 29(4), 431-436.
- Spatiotemporal release of VEGF from biodegradable polylactic-co-glycolic acid microspheres induces angiogenesis in chick chorionic allantoic membrane assay. International Journal of Pharmaceutics, 561, 236-243.
- Exploration of 2-deoxy-D-ribose and 17β-Estradiol as alternatives to exogenous VEGF to promote angiogenesis in tissue-engineered constructs. Regenerative Medicine. View this article in WRRO
- A dinuclear ruthenium(II) phototherapeutic that targets duplex and quadruplex DNA. Chemical Science, 10(12), 3502-3513. View this article in WRRO
- Complications related to use of mesh implants in surgical treatment of stress urinary incontinence and pelvic organ prolapse: infection or inflammation?. World Journal of Urology. View this article in WRRO
- Synthetic biodegradable alternatives to the use of the amniotic membrane for corneal regeneration: assessment of local and systemic toxicity in rabbits.. British Journal of Ophthalmology, 103, 286-292. View this article in WRRO
- Characterisation of structural changes in collagen with Raman spectroscopy. Applied Spectroscopy Reviews, 54(6), 509-542.
- Highly-branched poly(N-isopropyl acrylamide) functionalised with pendant Nile red and chain end vancomycin for the detection of Gram-positive bacteria. Acta Biomaterialia, 87, 197-206.
- Use of a simple in vitro fatigue test to assess materials used in the surgical treatment of stress urinary incontinence and pelvic organ prolapse. Neurourology and Urodynamics, 38(1), 107-115.
- Bioresorbable antibacterial PCL‐PLA‐nHA composite membranes for oral and maxillofacial defects. Polymer Composites, 40(4), 1564-1575.
- A methodology for the production of microfabricated electrospun membranes for the creation of new skin regeneration models. Journal of Tissue Engineering, 9. View this article in WRRO
- Antibiotic functionalised polymers reduce bacterial biofilm and bioburden in a simulated infection of the cornea. Biomaterials Science. View this article in WRRO
- Porous microspheres support mesenchymal progenitor cell ingrowth and stimulate angiogenesis. APL Bioengineering. View this article in WRRO
- An Improved In Vivo Methodology to Visualise Tumour Induced Changes in Vasculature Using the Chick Chorionic Allantoic Membrane Assay. In Vivo, 32(3). View this article in WRRO
- Overcoming scarring in the urethra: Challenges for tissue engineering. Asian Journal of Urology, 5(2), 69-77. View this article in WRRO
- A simple rocker-induced mechanical stimulus upregulates mineralization by human osteoprogenitor cells in fibrous scaffolds. Journal of Tissue Engineering and Regenerative Medicine, 12(2), 370-381. View this article in WRRO
- Demonstration of improved tissue integration and angiogenesis with an elastic, estradiol releasing polyurethane material designed for use in pelvic floor repair. Neurourology and Urodynamics, 37(2), 716-725.
- Repairing the female pelvic floor: when good enough is not good enough. Nature Reviews Urology, 15(4), 197-198.
- Visualisation of the insertion of a membrane for the treatment of preterm rupture of fetal membranes using a synthetic model of a pregnant uterus. Journal of Biomaterials Applications, 33(2), 234-244.
- Deoxy-sugar releasing biodegradable hydrogels promote angiogenesis and stimulate wound healing. Materials Today Communications, 13, 295-305. View this article in WRRO
- Measurement of friction-induced changes in pig aorta fibre organization by non-invasive imaging as a model for detecting the tissue response to endovascular catheters. Biotribology, 12, 24-32. View this article in WRRO
- Oxygen Mapping of Melanoma Spheroids using Small Molecule Platinum Probe and Phosphorescence Lifetime Imaging Microscopy.. Scientific Reports, 7. View this article in WRRO
- Oestradiol-releasing Biodegradable Mesh Stimulates Collagen Production and Angiogenesis: An Approach to Improving Biomaterial Integration in Pelvic Floor Repair. European urology focus. View this article in WRRO
- Development of a UV crosslinked biodegradable hydrogel containing adipose derived stem cells to promote vascularization for skin wounds and tissue engineering. Biomaterials, 129, 188-198.
- Modulation of the Early Host Response to Electrospun Polylactic Acid Matrices by Mesenchymal Stem Cells from the Amniotic Fluid.. Eur J Pediatr Surg.
- Consensus Statement of the European Urology Association and the European Urogynaecological Association on the Use of Implanted Materials for Treating Pelvic Organ Prolapse and Stress Urinary Incontinence. European Urology.
- Estradiol releasing hydrogel as a proangiogenic substitute for fat flaps used in urogenital reconstruction. European Urology Supplements, 16(3), e336-e337.
- Modifying the surface chemistry of biomaterials designed for surgical treatment of stress urinary incontinence to reduce bacterial adhesion. European Urology Supplements, 16(3), e1918-e1919.
- Development of improved tissue engineered buccal mucosa for treatment of urethral strictures. European Urology Supplements, 16(3), e1785-e1786.
- Stem Cell-Based Tissue-Engineered Laryngeal Replacement. Stem Cells Transl Med, 6(2), 677-687. View this article in WRRO
- Heparin binding chitosan derivatives for production of pro-angiogenic hydrogels for promoting tissue healing. Materials Science and Engineering: C.
- Haptotatic Plasma Polymerized Surfaces for Rapid Tissue Regeneration and Wound Healing. ACS Applied Materials & Interfaces, 8(48), 32675-32687.
- Ex vivo rabbit and human corneas as models for bacterial and fungal keratitis. Graefe's Archive for Clinical and Experimental Ophthalmology. View this article in WRRO
- Controlled peel testing of a model tissue for diseased aorta. Journal of Biomechanics, 49(15), 3667-3675. View this article in WRRO
- Investigating neovascularization in rat decellularized intestine - an in vitro platform for studying angiogenesis. Tissue Engineering - Part A., 22(23 - 24), 1317-1326. View this article in WRRO
- Second Harmonic Generation microscopy reveals collagen fibres are more organised in the cervix of postmenopausal women. Reproductive Biology and Endocrinology, 14. View this article in WRRO
- Triethyl orthoformate covalently cross-linked chitosan-(poly vinyl) alcohol based biodegradable scaffolds with heparin-binding ability for promoting neovascularisation. Journal of Biomaterials Applications, 31(4), 582-593. View this article in WRRO
- Fabrication of biodegradable synthetic vascular networks and their use as a model of angiogenesis. Cells Tissues Organs, 202(5-6). View this article in WRRO
- Antimicrobial Graft Copolymer Gels.. Biomacromolecules, 17(8), 2710-2718. View this article in WRRO
- A comparison of friction behaviour for ex vivo human, tissue engineered and synthetic skin. Tribology International, 103, 487-495. View this article in WRRO
- Peptides from Tetraspanin CD9 Are Potent Inhibitors of Staphylococcus Aureus Adherence to Keratinocytes. PLoS One, 11(7). View this article in WRRO
- Creating a model of diseased artery damage and failure from healthy porcine aorta. Journal of the Mechanical Behavior of Biomedical Materials, 60, 378-393. View this article in WRRO
- Production of chitosan PVA PCL hydrogels to bind heparin and induce angiogenesis. International Journal of Polymeric Materials and Polymeric Biomaterials, 65(9), 466-476.
- Production and Characterization of a Novel,
Electrospun, Tri-Layer Polycaprolactone Membrane
for the Segregated Co-Culture of Bone and Soft Tissue. Polymers, 8(6), 221-229. View this article in WRRO
- Use of a Tissue Engineered Human Skin Model to Investigate the Effects of Wounding and of an Anti-Inflammatory on Melanoma Cell Invasion. PLoS ONE, 11(6). View this article in WRRO
- Raman spectroscopy detects melanoma and the tissue surrounding melanoma using tissue-engineered melanoma models. Applied Spectroscopy Reviews, 51(4), 243-257. View this article in WRRO
- Developing repair materials for stress urinary incontinence to withstand dynamic distension. PLoS One, 11(3). View this article in WRRO
- 1028 Estradiol releasing polylactic acid scaffolds stimulate blood vessel formation-towards better integration of biomaterials for pelvic floor repair. European Urology Supplements, 15(3), e1028-e1028.
- Inkjet printing Schwann cells and neuronal analogue NG108-15 cells. Biofabrication, 8(1), 015017-015017. View this article in WRRO
- Biodegradable scaffolds designed to mimic fascia-like properties for the treatment of pelvic organ prolapse and stress urinary incontinence. Journal of Biomaterials Applications, 30(10), 1578-1588.
- Evaluating Alternative Materials for the Treatment of Stress Urinary Incontinence and Pelvic Organ Prolapse: A Comparison of the In Vivo Response to Meshes Implanted in Rabbits. The Journal of Urology, 196(1), 261-269.
- Photoluminescent and superparamagnetic reduced graphene oxide–iron oxide quantum dots for dual-modality imaging, drug delivery and photothermal therapy. Carbon, 97, 54-70. View this article in WRRO
- Human mesenchymal stromal cells from different sources diverge in their expression of cell surface proteins and display distinct differentiation patterns. Stem Cells International, 2016. View this article in WRRO
- Dental materials for cleft palate repair. Materials Science and Engineering: C, 61, 1018-1028.
- Development of an implantable synthetic membrane for the treatment of preterm premature rupture of fetal membranes. Journal of Biomaterials Applications, 30(7), 995-1003.
- Production of ascorbic acid releasing biomaterials for pelvic floor repair. Acta Biomaterialia, 29, 188-197. View this article in WRRO
- The Tissue-Engineered Vascular Graft—Past, Present, and Future. Tissue Engineering Part B: Reviews, 22(1), 68-100. View this article in WRRO
- Thermoresponsive, stretchable, biodegradable and biocompatible poly(glycerol sebacate)-based polyurethane hydrogels. Polymer Chemistry, 6, 7974-7987. View this article in WRRO
- Re: Guido Barbagli, Massimo Lazzeri. Clinical Experience with Urethral Reconstruction Using Tissue-engineered Oral Mucosa: A Quiet Revolution. Eur Urol. In press. http://dx.doi.org/10.1016/j.eururo.2015.05.043. European Urology, 68(5), e99-e100. View this article in WRRO
- Can you whistle? Then I'll come: stem cells home to where they're needed. British Journal of Dermatology, 172(5), 1183-1184. View this article in WRRO
- 1009 The in vitro response to fabricated oestradiol releasing scaffolds designed for the treatment of pelvic floor disorders. European Urology Supplements, 14(2), e1009-e1009.
- 1004 Cyclical stretch conditioning of an elastomeric cell-seeded pelvic floor repair material using a closed bioreactor system. European Urology Supplements, 14(2), e1004-e1004a.
- 1005 Histological and mechanical outcomes of two novel scaffolds as alternative materials for surgery of prolapse. European Urology Supplements, 14(2), e1005-e1005.
- Biomimetic poly(glycerol sebacate)/poly(l-lactic acid) blend scaffolds for adipose tissue engineering. Acta Biomaterialia, 18, 40-49. View this article in WRRO
- Rocking Media Over Ex Vivo Corneas Improves This Model and Allows the Study of the Effect of Proinflammatory Cytokines on Wound Healing. Investigative Ophthalmology & Visual Science, 56(3), 1553-1561. View this article in WRRO
- Vascularization strategies for tissue engineers. Regenerative Medicine, 10(2), 211-224. View this article in WRRO
- Simple surface coating of electrospun poly-L-lactic acid scaffolds to induce angiogenesis. Journal of Biomaterials Applications, 30(1), 50-60. View this article in WRRO
- Fabrication of biodegradable synthetic perfusable vascular networks via a combination of electrospinning and robocasting. Biomaterials Science, 3(4), 592-596. View this article in WRRO
- Application of Tissue Engineering to Pelvic Organ Prolapse and Stress Urinary Incontinence. LUTS: Lower Urinary Tract Symptoms, 7(2), 63-70. View this article in WRRO
- Imaging of 3D Tissue-Engineered Models of Oral Cancer Using 890 and 1300 nm Optical Coherence Tomography. Sovremennye tehnologii v medicine, 7(1), 60-68. View this article in WRRO
- Tissue engineered buccal mucosa for urethroplasty: Progress and future directions. Advanced Drug Delivery Reviews, 82-83, 69-76. View this article in WRRO
- Biomaterials for Pelvic Floor Reconstructive Surgery: How Can We Do Better?. BioMed Research International, 2015, 1-20. View this article in WRRO
- Development of a Basement Membrane Substitute Incorporated Into an Electrospun Scaffold for 3D Skin Tissue Engineering. Journal of Biomaterials and Tissue Engineering, 4(9), 686-692.
- The effect of ascorbic acid and fluid flow stimulation on the mechanical properties of a tissue engineered pelvic floor repair material. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 228(9), 867-875.
- Acute In Vivo Response to an Alternative Implant for Urogynecology. BioMed Research International, 2014. View this article in WRRO
- Förster resonance energy transfer confirms the bacterial-induced conformational transition in highly-branched poly(N-isopropyl acrylamide with vancomycin end groups on binding to Staphylococcus aureus.. Soft Matter, 10(31), 5824-5835.
- Surface functionalization of electro-spun Poly(L) Lactic Acid scaffolds with heparin to induce angiogenesis. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 8, 169-169.
- Development of 3D skin models for in vitro testing. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 8, 377-377.
- Pulsatile exposure to simulated reflux leads to changes in gene expression in a 3D model of oesophageal mucosa.. Int J Exp Pathol, 95(3), 216-228. View this article in WRRO
- Translocation of flexible polymersomes across pores at the nanoscale. Biomaterials Science, 2(5), 680-692.
- Polymersome-mediated delivery of combination anticancer therapy to head and neck cancer cells: 2D and 3D in vitro evaluation.. Mol Pharm, 11(4), 1176-1188.
- 486 Biomimetic design of an autologous cell seeded scaffold for pelvic floor repair. European Urology Supplements, 13(1), e486-e486a.
- 476 Tissue engineered oestradiol releasing slings for the treatment of stress urinary incontinence. European Urology Supplements, 13(1), e476-e476a.
- Response to letter to the editor: 'construction of skin substitutes using minced split-thickness autografts and biodegradable synthetic scaffolds'.. Burns, 40(6), 1233-1234.
- Amine functional hydrogels as selective substrates for corneal epithelialization.. Acta Biomater, 10(7), 3029-3037.
- Monitoring fibrous scaffold guidance of three-dimensional collagen organisation using minimally-invasive second harmonic generation.. PLoS One, 9(2), e89761. View this article in WRRO
- Characterisation and evaluation of the impact of microfabricated pockets on the performance of limbal epithelial stem cells in biodegradable PLGA membranes for corneal regeneration. Biomaterials Science, 2(5), 723-734. View this article in WRRO
- Long-term Follow-up After Tissue-engineered Buccal Mucosa Urethroplasty. European Urology, 66(4), 790-791.
- An 'off-the shelf' synthetic membrane to simplify regeneration of damaged corneas. Middle East Conference on Biomedical Engineering, MECBME, 59-62.
- Transforming ocular surface stem cell research into successful clinical practice. Indian Journal of Ophthalmology, 62(1), 29-40.
- Developing a tissue engineered repair material for treatment of stress urinary incontinence and pelvic organ prolapse-which cell source?. Neurourol Urodyn, 33(5), 531-537.
- Glucomannan-poly(N-vinyl pyrrolidinone) bicomponent hydrogels for wound healing. Journal of Materials Chemistry B.
- DALLOS AWARD 2013: Developing methods to track the migration of transplanted corneal limbal stem cells. Contact Lens and Anterior Eye, 36, e35-e35.
- Development of a one-step approach for the reconstruction of full thickness skin defects using minced split thickness skin grafts and biodegradable synthetic scaffolds as a dermal substitute.. Burns.
- Tissue engineering airway mucosa: a systematic review.. Laryngoscope.
- The development of a 3D immunocompetent model of human skin. BIOFABRICATION, 5(3).
- Development of bilayer and trilayer nanofibrous/microfibrous scaffolds for regenerative medicine. Biomaterials Science, 1(9), 942-951.
- Combined Effects of Capsaicin and HA14-1 in Inducing Apoptosis in Melanoma Cells. Journal of Cosmetics, Dermatological Sciences and Applications, 03(03), 175-189.
- Simplifying corneal surface regeneration using a biodegradable synthetic membrane and limbal tissue explants.. Biomaterials, 34(21), 5088-5106.
- Comparison of candidate scaffolds for tissue engineering for stress urinary incontinence and pelvic organ prolapse repair.. BJU Int, 112(5), 674-685.
- Development of a microfabricated artificial limbus with micropockets for cell delivery to the cornea.. Biofabrication, 5(2), 025008.
- Skin stem cell hypotheses and long term clone survival--explored using agent-based modelling.. Sci Rep, 3, 1904. View this article in WRRO
- The use of allodermis prepared from Euro skin bank to prepare autologous tissue engineered skin for clinical use.. Burns, 39(6), 1170-1177.
- High molecular weight plant heteropolysaccharides stimulate fibroblasts but inhibit keratinocytes.. Carbohydr Res, 375, 90-99.
- 110 Development of tissue engineered bio-absorbable cellularised mesh for stress urinary incontinence and pelvic organ prolapse: The effect of chemical and mechanical stimulation on improving tensile properties. European Urology Supplements, 12(1), e110-e110.
- 873 Reducing the risk in the production of tissue engineered buccal mucosa for urethral reconstruction. European Urology Supplements, 12(1), e873-e873.
- 109 In vivo assessment of the acute host response against a novel tissue engineered to treat stress urinary incontinence and pelvic organ prolapse. European Urology Supplements, 12(1), e109-e109.
- Enhanced drug delivery to melanoma cells using PMPC-PDPA polymersomes.. Cancer Lett, 334(2), 328-337.
- Tissue engineering as a potential alternative or adjunct to surgical reconstruction in treating pelvic organ prolapse: comment on Boennelycke et al.. Int Urogynecol J, 24(5), 881.
- Cultivation of limbal epithelial cells on electrospun poly (lactide-co-glycolide) scaffolds for delivery to the cornea.. Methods Mol Biol, 1014, 179-185.
- The effect of adipose tissue derived MSCs delivered by a chemically defined carrier on full-thickness cutaneous wound healing. Biomaterials.
- Combined microfabrication and electrospinning to produce 3-D architectures for corneal repair.. Acta Biomater, 9(3), 5511-5520.
- Developing tissue-engineered solutions for the treatment of extensive urethral strictures.. Eur Urol, 63(3), 539-541.
- Arginine functionalization of hydrogels for heparin binding--a supramolecular approach to developing a pro-angiogenic biomaterial.. Biotechnol Bioeng, 110(1), 296-317.
- Electrospun biaxially distensible bilayer membranes to treat cleft palate. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 6, 340-340.
- Development of a 3D neuronal glial co-culture model for peripheral nerve studies and repair strategies. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 6, 352-352.
- Synthesis and preparation of konjac glucomannan hydrogel for wound healing. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 6, 186-187.
- Biologically active copolymer hydrogels. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 6, 213-213.
- Development of tissue engineered stem cell niches for corneal repair. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 6, 137-137.
- Transplantation of oral mucosa explants using different biological and synthetic membranes in an attempt to achieve one-stage reconstruction of soft-tissue defects. Oral Surgery, 5(3), 118-126.
- A SIMPLE SHEAR STRESS MODEL FOR ENHANCING MATRIX PRODUCTION IN OSTEOGENIC PROGENITORS. Journal of Biomechanics, 45, S650-S650.
- Mesh social networking: a patient-driven process.. BJU Int, 109(12), E45-E46.
- Tissue engineered oral mucosa for urethroplasty: past experience and future directions.. J Urol, 187(5), 1533-1534.
- Transdermal drug delivery: from micro to nano.. Nanoscale, 4(6), 1881-1894.
- 1065 Examining the effect of subjecting a tissue engineered pelvic floor repair material to fixed and dynamic stress during its production to improve the biomechanical properties for future use in stress urinary incontinence and pelvic organ prolapse. European Urology Supplements, 11(1), e1065-e1065a.
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- The Effect of Cell Cytosol on Adenylate Cyclase Activation in Particulate Preparations. Biochemical Society Transactions, 7(5), 1030-1030.
- LONGITUDINAL-STUDIES OF PLASMA ADENOSINE 3'-5'-CYCLIC MONOPHOSPHATE RESPONSIVENESS TO GLUCAGON DURING TREATMENT OF THYROTOXICOSIS. CLIN SCI, 56(3), P16-P16.
- FACTOR IN CYTOSOL ENHANCES STIMULATION OF MEMBRANE ADENYLATE-CYCLASE FROM HUMAN THYROID BY THYROTROPIN AND THYROID STIMULATING IMMUNOGLOBULINS. FEBS LETT, 107(2), 269-272.
- SOLUBLE CYCLIC AMP-DEPENDENT PROTEIN-KINASES FROM CHICK KIDNEY - EFFECTS OF DILUTION AND NON-PROTEIN INHIBITORS. BIOCHIM BIOPHYS ACTA, 582(3), 504-514.
- EFFECT OF EXTRACELLULAR FLUID AND OF CYTOSOL ON PARTICULATE ADENYLATE-CYCLASE ACTIVITY. J ENDOCRINOL, 81(2), P150-P151.
- EFFECTS OF HUMAN PARATHYROID-HORMONE FRAGMENTS ON HUMAN KIDNEY ADENYLATE-CYCLASE ACTIVITY. P AUST BIOCHEM SOC, 11, 46-46.
- RESPONSE OF HUMAN AND CHICK KIDNEY ADENYLATE-CYCLASE TO BIOLOGICALLY-ACTIVE SYNTHETIC FRAGMENTS OF HUMAN PARATHYROID-HORMONE. BIOCHEM BIOPH RES CO, 81(2), 581-587.
- INHIBITORY EFFECT OF LITHIUM ON RESPONSE TO INTRAVENOUS GLUCAGON IN MAN. CLIN SCI MOL MED, 55(3), P31-P31.
- DIURETICS AND RENAL ADENYLATE-CYCLASE SYSTEM. BRIT J PHARMACOL, 61(4), 657-667.
- LITHIUM AND ANTIDIURETIC-HORMONE. BRIT J CLIN PHARMACO, 3(2), 305-313.
- The increased antidiuretic activity of rat urine following lithium administration. Journal of Physiology, 245(2).
- INCREASED ANTIDIURETIC ACTIVITY OF RAT URINE FOLLOWING LITHIUM ADMINISTRATION. J PHYSIOL-LONDON, 245(2), P98-P99.
- EFFECTS OF LITHIUM IONS ON ANTIDIURETIC ACTION OF VASOPRESSIN IN RAT. BRIT J PHARMACOL, 55(4), 527-534.
- LACK OF RELATIONSHIP BETWEEN CONCENTRATION OF LITHIUM AND INHIBITION OF ACTION OF VASOPRESSIN BY LITHIUM IN RAT. J PHYSIOL-LONDON, 251(1), P28-P29.
- DIURETICS DURING LITHIUM-THERAPY. LANCET, 1(7919), 1295-1296.
- Angiogenesis Dynamics: A Computational Model of Intravascular Flow Within a Structural Adaptive Vascular Network. Biomedicines, 12(12), 2845-2845.
- Development of a Clinically Relevant Preclinical Animal Model to Mimic Suburethral Implantation of Support Materials for Stress Urinary Incontinence. Neurourology and Urodynamics.
- Corrigendum: Stimulation of hair regrowth in an animal model of androgenic alopecia using 2-deoxy-D-ribose. Frontiers in Pharmacology, 15.
- Where are we in 2024 in the development of materials for surgical treatment of pelvic organ prolapse and stress urinary incontinence?. Current Opinion in Urology.
- Stimulation of hair regrowth in an animal model of androgenic alopecia using 2-deoxy-D-ribose. Frontiers in Pharmacology, 15.
- Development of a tissue-engineered skin model with epidermal, dermal and hypodermal components. In vitro models.
- A physiologically relevant, estradiol‐17β [E2]‐responsive in vitro tissue‐engineered model of the vaginal epithelium for vaginal tissue research. Neurourology and Urodynamics.
- A Dinuclear Osmium(II) Complex Near-Infrared Nanoscopy Probe for Nuclear DNA. Journal of the American Chemical Society.
- Thiolene- and Polycaprolactone Methacrylate-Based Polymerized High Internal Phase Emulsion (PolyHIPE) Scaffolds for Tissue Engineering. Biomacromolecules.
- Sprouting Angiogenesis: A Numerical Approach with Experimental Validation. Annals of Biomedical Engineering.
- Author Correction: Regenerative medicine and injection therapies in stress urinary incontinence. Nature Reviews Urology.
- Establishing a Porcine Ex Vivo Cornea Model for Studying Drug Treatments against Bacterial Keratitis. Journal of Visualized Experiments(159).
- Correction: A dinuclear ruthenium(ii) phototherapeutic that targets duplex and quadruplex DNA. Chemical Science, 11(9), 2566-2566.
- Developing a synthetic composite membrane for cleft palate repair. Journal of Tissue Engineering and Regenerative Medicine.
- Developing improved tissue-engineered buccal mucosa grafts for urethral reconstruction. Canadian Urological Association Journal, 12(5), E234-42.
- Utilising Inkjet Printed Paraffin Wax for Cell Patterning Applications. International Journal of Bioprinting, 2(0).
- Production, Characterization and Potential Uses of a 3D Tissue-engineered Human Esophageal Mucosal Model. Journal of Visualized Experiments(99). View this article in WRRO
- Production, Characterization and Potential Uses of a 3D Tissue-engineered Human Esophageal Mucosal Model. Journal of Visualized Experiments(99).
- Biodegradable and conductive chitosan–graphene quantum dot nanocomposite microneedles for delivery of both small and large molecular weight therapeutics. RSC Advances, 5(64), 51934-51946. View this article in WRRO
- Application of layer-by-layer coatings to tissue scaffolds – development of an angiogenic biomaterial. J. Mater. Chem. B, 2(34), 5558-5568.
- Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration. Journal of Visualized Experiments(91).
- Use of anin VitroModel of Tissue-Engineered Skin to Investigate the Mechanism of Skin Graft Contraction. Tissue Engineering, 0(0), 061004065151003-061004065151003.
- Modeling the Effect of Exogenous Calcium on Keratinocyte and HaCat Cell Proliferation and Differentiation Using an Agent-Based Computational Paradigm. Tissue Engineering, 0(0), 060913044658037-060913044658037.
- Elevated platelet-free calcium in uraemia. British Journal of Haematology, 74(3), 300-305.
- Recent advances in pelvic floor repair. F1000Research, 8. View this article in WRRO
- Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration. Journal of Visualized Experiments(91), e51826-e51826. View this article in WRRO
- Tuning Electrospun Substrate Stiffness for the Fabrication of a Biomimetic Amniotic Membrane Substitute for Corneal Healing. ACS Applied Bio Materials.
- Delivery of Bioactive Compounds to Improve Skin Cell Responses on Microfabricated Electrospun Microenvironments. Bioengineering, 8(8), 105-105.
Chapters
- Plasma copolymerized surfaces to enhance cell culture, Polymer Surface Modification: Relevance to Adhesion, Volume 2 (pp. 539-549). CRC Press
- Engineering of Accepted Skin-Equivalent Tissue for Tissue Repair: Current State and Perspectives, Reference Module in Biomedical Sciences Elsevier
- Engineering of Accepted Skin-Equivalent Tissue for Tissue Repair: Current State and Perspectives, Encyclopedia of Tissue Engineering and Regenerative Medicine: Volumes 1-3 (pp. V1-285-V1-298).
- Development of a paracrine-signaling model for detecting irritancy using human keratinocytes and fibroblasts In Haycock J, Ahluwalia A & Wilkinson J (Ed.), Cellular in Vitro Testing: Methods and Protocols (pp. 109-121). Singapore: Pan Stanford.
- Utilizing Nanosensor-Incorporated Scaffolds in the Development of a 3D Lung Model, Cellular In Vitro Testing (pp. 105-124). Jenny Stanford Publishing
- Development of a Paracrine-Signaling Model for Detecting Irritancy Using Human Keratinocytes and Fibroblasts, CELLULAR IN VITRO TESTING: METHODS AND PROTOCOLS (pp. 109-121).
- Tracking nanoparticles in three-dimensional tissue-engineered models using confocal laser scanning microscopy. (pp. 41-51).
- Cultured buccal mucosa grafts: Current status, Textbook of Reconstructive Urologic Surgery (pp. 510-515).
- Tissue Engineered Skin Comes of Age?, Advances in Tissue Engineering (pp. 593-618). PUBLISHED BY IMPERIAL COLLEGE PRESS AND DISTRIBUTED BY WORLD SCIENTIFIC PUBLISHING CO.
- Synthesis and Properties of Functional Poly(vinylpyrrolidinone) Hydrogels for Drug Delivery, ACS Symposium Series (pp. 196-203). American Chemical Society
- Skin tissue engineering, Tissue Engineering Using Ceramics and Polymers (pp. 379-403).
- Synthetic Materials Used in the Surgical Treatment of Pelvic Organ Prolapse: Problems of Currently Used Material and Designing the Ideal Material, Pelvic Floor Disorders InTech
- Exploring treatments for ocular surface diseases, Nanomaterials and regenerative medicine (pp. 453-476). IAPC Publishing
Conference proceedings papers
- In-vitro evaluation of macrophage response to polypropylene mesh before and after application of mechano-oxidative stress. European Urology, Vol. 83 (pp S1190-S1190)
- THERE'S MORE TO FAT THAN STEM CELLS, CHARACTERISING FAT GRAFT MATERIALS TO UNDERSTAND THE REGENERATIVE PROPERTIES OF ADIPOSE TISSUES. TISSUE ENGINEERING PART A, Vol. 28 (pp S544-S544)
- Development of a topical prodrug to treat burn scar contracture. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 257
- Evaluation of the angiogenic and osteogenic activity of two potent alternatives to VEGF: 2-deoxy-D-ribose (2dDR) and 17 beta-Estradiol (E2) loaded tissue engineering scaffolds. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 256
- USE OF ACCELERATED FATIGUE TESTING AS A SIMPLE IN VITRO TEST FOR ASSESSING MATERIALS FOR THE SURGICAL TREATMENT OF STRESS URINARY INCONTINENCE AND PELVIC ORGAN PROLAPSE. NEUROUROLOGY AND URODYNAMICS, Vol. 37 (pp S379-S380)
- Tissue-Engineered Blood Vessels with User-Defined Geometries. TISSUE ENGINEERING PART A, Vol. 23 (pp S140-S140)
- COMPARABLE VAGINALWALL BIOMECHANICAL PROPERTIES FOLLOWING ELECTROSPUN POLYCARBONATE- UREIDOPYRIMIDONE MESH IMPLANTATION AND SIMULATED NATIVE TISSUE REPAIR IN SHEEP. INTERNATIONAL UROGYNECOLOGY JOURNAL, Vol. 28 (pp S37-S38)
- Corneal infections: targeted eradication through antibiotic functionalized polymers. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol. 58(8)
- System for tracking transplanted limbal epithelial stem cells in the treatment of corneal stem cell deficiency
(Conference Presentation). Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues IX, 13 February 2016 - 18 February 2016.
- 1300 nm and 890 nm OCT images of oral cancer tissue engineered models and biopsy samples offer complimentary performance (Conference Presentation). Photonic Therapeutics and Diagnostics XII, 13 February 2016 - 18 February 2016.
- The Use of Second-Harmonic-Generation (SHG) to Assess the Impact of Menopause on the Orientation of Collagen Fibres in the Human Cervix.. REPRODUCTIVE SCIENCES, Vol. 23 (pp 214A-214A)
- Optical measurement of oxygen concentration in melanoma spheroid and skin engineered models. European Cells and Materials (ECM), Vol. Collection 5 (pp 8-8)
- Developing a Degradable Polymer Scaffold for Vascular Graft Tissue Engineering using a Novel Photocurable Poly(glycerol Sebacate). TISSUE ENGINEERING PART A, Vol. 21 (pp S182-S182)
- Physiological and Biological Effects of Konjac Glucomannan Hydrogels on Human Tissue Engineered Skin. TISSUE ENGINEERING PART A, Vol. 21 (pp S304-S304)
- Estradiol Releasing Scaffolds for the Treatment of Pelvic Floor Disorders. TISSUE ENGINEERING PART A, Vol. 21 (pp S202-S202)
- Nine Year Follow Up on Tissue Engineered Buccal Mucosa used for Urethroplasty - What have we Learnt?. TISSUE ENGINEERING PART A, Vol. 21 (pp S34-S34)
- Composite Materials for Pelvic Floor Repair Which Cope with Dynamic Distension and Support Cell Integration. TISSUE ENGINEERING PART A, Vol. 21 (pp S215-S215)
- Development of a Three-Dimensional In Vitro Model to Study Neovascularization. TISSUE ENGINEERING PART A, Vol. 21 (pp S325-S326)
- RESPONSE OF SCAFFOLD MATERIALS DESIGNED FOR TREATMENT OF STRESS URINARY INCONTINENCE (SUI) AND PELVIC ORGAN PROLAPSE (POP) TO DISTENSION. NEUROUROLOGY AND URODYNAMICS, Vol. 34 (pp S291-S292)
- THE IN VIVO RESPONSE TO IMPLANTABLE ENGINEERED REPAIR MATERIALS DESIGNED FOR PELVIC FLOOR RECONSTRUCTION. NEUROUROLOGY AND URODYNAMICS, Vol. 34 (pp S289-S290)
- Models of microbial keratitis in ex vivo rabbit and human corneas. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol. 56(7)
- System for tracking transplanted limbal epithelial stem cells in the treatment of corneal stem cell deficiency. Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XIII
- Polymer colloids for the controlled elease of heparin binding growth factors. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 248
- Poly(N-isopropyl acrylamide) responsive to the presence of bacteria. Abstracts of papers of the American Chemical Society, Vol. 248, 10 August 2014 - 14 August 2014.
- Microfabrication of artificial stem cell microenvironments for tissue regeneration. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol. 8 (pp 175-176)
- Oxygen difference in live melanoma muticellular tumour spheroids using novel platinum compound and time-resolved imaging microscopy. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol. 8 (pp 314-314)
- Studies on the Friction Coefficient of Human Skin and Skin Substitutes. Proceedings of International Conference on Biotribology (ICoBT)
- Improving elastogenesis in a tissue engineered repair material for pelvic floor surgery. BRITISH JOURNAL OF SURGERY, Vol. 101 (pp 60-60)
- Microfabricated niches for the culture of limbal epithelial cells. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol. 55(13)
- Biomechanical optimisation of a tissue engineered prosthesis for pelvic floor repair. BRITISH JOURNAL OF SURGERY, Vol. 100 (pp 66-66)
- Safe, efficient and painless delivery of MSCs from a chemically defined carrier accelerating murine full-thickness wounds. EXPERIMENTAL DERMATOLOGY, Vol. 22(3) (pp E45-E45)
- Production, sterilisation and storage of biodegradable electrospun PLGA membranes for delivery of limbal stem cells to the cornea. 3RD INTERNATIONAL CONFERENCE ON TISSUE ENGINEERING (ICTE2013), Vol. 59 (pp 101-116)
- Barrett's Metaplasia: Exploiting a Tissue-engineered Model to Understand the Response of the Oesophageal Squamous Mucosa to Bile and Acid Exposure. JOURNAL OF PATHOLOGY, Vol. 228 (pp S3-S3)
- Optimizing cell sources for cleft palate repair. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol. 6 (pp 4-4)
- DEVELOPING AN AUTOLOGOUS ENGINEERED CONNECTIVE TISSUE USING A BIODEGRADABLE SCAFFOLD FOR THE TREATMENT OF STRESS URINARY INCONTINENCE AND PELVIC ORGAN PROLAPSE. NEUROUROLOGY AND URODYNAMICS, Vol. 31(6) (pp 917-919)
- Investigation of Raman Spectroscopy and Optical Coherence Tomography to Aid in Diagnosis of Oral Cancer. EUROPEAN JOURNAL OF CANCER, Vol. 48 (pp S287-S287)
- Assessment of a variable stress rig to improve the properties of a tissue engineered prosthesis for use in stress urinary incontinence and pelvic organ prolapse. BRITISH JOURNAL OF SURGERY, Vol. 99 (pp 58-59)
- Increasing collagen production and contraction with ascorbate in a tissue engineered autologus prosthesis for use in the treatment of stress urinary incontinence (SUI) and pelvic organ prolapse (POP). BRITISH JOURNAL OF SURGERY, Vol. 98(6) (pp E7-E7)
- Engineering a novel tissue engineered autologus prosthesis for use in stress urinary incontinence (SUI) and pelvic organ prolapse (POP) repair. BRITISH JOURNAL OF SURGERY, Vol. 98(6) (pp E6-E6)
- Creating a tissue engineered prosthesis for stress urinary incontinence and pelvic organ prolapse, which scaffold?. BRITISH JOURNAL OF SURGERY, Vol. 98 (pp 4-5)
- Development of aseptically produced scaffolds for substitution urethroplasty. BRITISH JOURNAL OF SURGERY, Vol. 98 (pp 54-54)
- Response of dermal fibroblasts to dynamic tensile loading. European Cells and Materials, Vol. 22(SUPPL.2) (pp 41)
- Using a tissue engineering approach for the treatment of cleft palate. European Cells and Materials, Vol. 22(SUPPL.3) (pp 6)
- Robot companions for citizens. Procedia Computer Science, Vol. 7 (pp 47-51) View this article in WRRO
- COMPARATIVE INVESTIGATION OF SEVEN CANDIDATE SCAFFOLDS FOR THE PRODUCTION OF AN AUTOLOGOUS TISSUE ENGINEERED CONNECTIVE TISSUE FOR USE IN STRESS URINARY INCONTINENCE AND PELVIC ORGAN PROLAPSE. NEUROUROLOGY AND URODYNAMICS, Vol. 30(6) (pp 868-870)
- Invasive behaviour of the OE33 oesophageal adenocarcinoma cell line is dependent on co-operation with fibroblasts.. JOURNAL OF PATHOLOGY, Vol. 222 (pp S43-S43)
- Using tissue-engineered oral cancer models to evaluate non-invasive diagnostic technologies. ORAL DIS, Vol. 16(6) (pp 518-518)
- DEVELOPING AN AUTOLOGOUS TISSUE ENGINEERED PROSTHESIS FOR USE IN STRESS URINARY INCONTINENCE AND PELVIC ORGAN PROLAPSE. NEUROUROLOGY AND URODYNAMICS, Vol. 29(6) (pp 1129-1130)
- Hypoxia-induced secretion of CXCL12 by head and neck tumour spheroids mediates infiltration of monocytes by a CXCR4-dependent mechanism. ORAL ONCOLOGY (pp 68-68)
- The development of in vitro models of squamous cell carcinoma of the oral mucosa - From mild dysplasia to an expanding carcinoma. ORAL ONCOLOGY (pp 160-160)
- Management of a chronic vasculitic leg ulcer with systemic immunosuppressant therapy and autologous keratinocyte cell spray. BRITISH JOURNAL OF DERMATOLOGY, Vol. 161 (pp 124-124)
- Penetration of polymersome drug and gene delivery nanoparticles into in vitro models of head and neck cancer and tissue engineered oral mucosa. ORAL ONCOLOGY (pp 66-66)
- Investigations of cell-cell and cell-matrix interaction in skin wound repair using the scratch assay. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Vol. 90(2) (pp A134-A134)
- GaAs Based Quantum Dot Superluminescent Diodes for Optical Coherence Tomography of Skin Tissue. 2009 4TH INTERNATIONAL CONFERENCE ON COMPUTERS AND DEVICES FOR COMMUNICATION (CODEC 2009) (pp 426-431)
- Optical coherence tomography with high power quantum-dot superluminescent diodes. 2009 IEEE LEOS ANNUAL MEETING CONFERENCE PROCEEDINGS, VOLS 1AND 2 (pp 207-208)
- Imaging of polymersome penetration into 3D tissue engineered models of oral mucosa and head and neck cancer. European Cells and Materials, Vol. 16(SUPPL. 3) (pp 58)
- Use of aligned polymer microfibres for peripheral nerve repair. TISSUE ENGINEERING, Vol. 13(7) (pp 1774-1774)
- Use of tissue-engineered skin to enhance understanding of skin graft contraction. TISSUE ENGINEERING, Vol. 13(7) (pp 1774-1774)
- Improved technologies for translating culture of human melanocytes to the clinic. TISSUE ENGINEERING, Vol. 13(7) (pp 1711-1711)
- Use of a rabbit cornea model for the development of a cell transfer system for limbal epithelial cells. TISSUE ENGINEERING, Vol. 13(7) (pp 1773-1773)
- Cell culture on RGD-containing hydrogels. TISSUE ENGINEERING, Vol. 13(7) (pp 1649-1649)
- Development of biocompatible, biodegradable electrospun scaffolds for tissue engineering of human skin. TISSUE ENGINEERING, Vol. 13(7) (pp 1670-1671)
- Ibuprofen and hydrogel released ibuprofen in the reduction of inflammation induced migration in melanoma cells. TISSUE ENGINEERING, Vol. 13(7) (pp 1708-1709)
- Use of biomaterials in the regeneration of skin. TISSUE ENGINEERING, Vol. 13(4) (pp 875-875)
- Polymethacrylate networks as substrates for cell culture. MACROMOLECULAR SYMPOSIA, Vol. 256 (pp 137-148)
- Delivering cell therapy for chronic wounds. Medical Textiles and Biomaterials for Healthcare (pp 476-481)
- Amphiphilic poly (glycerol methacrylate-block-butyl methacrylate) copolymer networks: Synthesis and biointeractions. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 230 (pp U1218-U1218)
- Melanocyte and keratinocyte culture on plasma polymers for the treatment of patients with vitiligo. BRITISH JOURNAL OF DERMATOLOGY, Vol. 152(4) (pp 856-857)
- Regulation of the MYC network in the progression to oesophageal adenocarcinoma. GUT, Vol. 54 (pp A87-A87)
- Antioxidant and anti-inflammatory activities of melanocortin peptides. EXPERIMENTAL DERMATOLOGY, Vol. 13(9) (pp 576-576)
- Sodium salicylate inhibits inflammation induced invasion and migration of human melanoma cells. BRITISH JOURNAL OF CANCER, Vol. 91 (pp S71-S71)
- Development and characterisation of tissue-engineered buccal mucosa for urethroplasty. JOURNAL OF UROLOGY, Vol. 171(4) (pp 18-18)
- TNF-alpha increases human melanoma cell invasion and migration in vitro - The role of proteolytic enzymes. BRITISH JOURNAL OF CANCER, Vol. 88 (pp S66-S66)
- Latanoprost-induced pigmentation in human iridial melanocytes is fibroblast dependent. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol. 44 (pp U517-U517)
- Comparison of proliferation and growth of human keratinocytes on plasma co-polymers of acrylic acid/1,7-octadiene and self assembled monolayers. PLASMA DEPOSITION AND TREATMENT OF POLYMERS, Vol. 544 (pp 39-44)
- INTRACELLULAR SIGNALING IN THE CONTROL OF MELANOGENESIS. PIGMENT CELL RESEARCH (pp 154-161)
- A soluble endogenous regulator of adenylate cyclase. Biochemical Society Transactions, Vol. 9(2)
- SIMILARITY OF HUMAN THYROID ADENYLATE-CYCLASE RESPONSE TO THYROTROPIN (TSH) AND THYROID STIMULATING IMMUNOGLOBULINS (TSIG). CLIN SCI, Vol. 60(3) (pp P10-P10)
- ACTIVATION OF HUMAN THYROID MEMBRANE ADENYLATE-CYCLASE BY THYROID-STIMULATING IMMUNOGLOBULINS REQUIRES THE PRESENCE OF A FACTOR PRESENT IN THE CELL CYTOSOL. J ENDOCRINOL, Vol. 85(2) (pp P27-P28)
- ADENYLATE-CYCLASE ACTIVATING FACTOR IN CYTOSOL OF RAT OSTEOGENIC-SARCOMA. J ENDOCRINOL, Vol. 81(2) (pp P151-P152)
- There’s more to fat than stem cells, characterising fat graft materials to understand the regenerative properties of adipose tissues. eCM Meeting Abstracts 2020, Collection 1, Vol. Collection 1(2020 TERMIS EU) (pp 158-158)
- Ex vivo and in vivo OCT image contrast. Proceedings of SPIE - The International Society for Optical Engineering, Vol. 7139. 2008, 8 September 2008 - 10 September 2008.
Presentations
- Developing Cell Carriers for Delivering Cells from the Laboratory to the Clinic – Clinical and Commercial Experiences. The Octagon Centre, University of Sheffield.
- Cellular In Vitro Testing: Methods and Protocols. Singapore: Pan Stanford Publishing.
- Grants
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- 2021-2024 Tissue engineered in vitro models to transform the pre-clinical development pathways for pelvic floor repair materials used in surgical treatment of women with urinary incontinence. Royal Society / Turkish Government. £79,000.
- 2021-2024 Development of advanced pro angiogenic wound dressings for patients in Pakistan with diabetic ulcers and burns, injuries. British Council and Pakistan Institute for Higher Education. £250,000 in total.
- 2020-2021 The Urology Foundation Research - A scholarship grant to Sanad Saad. £92,299.
- 2018-2021 Exploration of the use of patients own fat to reduce burns graft scarring and contraction, S.MacNeil,V,Hearnden, N. Green and V. Giblin. Sheffield Hospitals Charity. £207,150
- 2018-2021 Membrane microdomains as a target for antimicrobial drug discovery, PN Monk, S MacNeil, LJ Partridge, E Karunakaran, P Thokala, TE Bartlett. MRC-GCRF. £1 397 587
- Professional activities and memberships
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- Awarded the Institute of Materials, Minerals and Mining (IOM3) Chapman Medal for Biomedical Materials and Biomaterials Innovation (2018).
- Awarded the President's Prize from UK Society for Biomaterials in recognition of long standing service to biomaterials science both in the UK and internationally (2014)
- Member of EPSRC Peer Review College (2010 onwards)
- Member of UK Tissue and Cell Engineering Society (TCES) (2009 onwards)
- Member of Swiss National Science Foundation NRP 63 - Stem Cells and Regenerative Medicine (2008 onwards)
- NC3R Grant Reviewing Panel (2008 - 2011)
- MRC Small Grant Reviewing Panel (2006-2007)
- Member of EPSRC Grant Reviewing College (2003-2006)
- Member of BBSRC Engineering and Biological Systems Panel (2000-2003)
- Member of MRC Regenerative Medicine Research Committee
- Women in Engineering
We interviewed Sheila for the Faculty of Engineering's Wall of Women when she was Professor of Tissue Engineering. Here are Sheila's interviews:
The Wall of Women profiles were taken over a 4/5 year time period and are a snapshot of what our engineers were doing at that time.
