Dr Zoltán Kis

Journal articles

• Nourafkan E, Kenyon C, Nair A, Loveday KA, Welbourne EN, Tao M, Ahmed M, Middleton J, Dickman MJ, Brown SF , Maamra M et al (2024) An experimental and modeling approach to study tangential flow filtration performance for mRNA drug substance purification. Biotechnology Journal, 19(11). View this article in WRRO
• Qu J, Nair A, Muir GW, Loveday KA, Yang Z, Nourafkan E, Welbourne EN, Maamra M, Dickman MJ & Kis Z (2024) Quality by design for mRNA platform purification based on continuous oligo-dT chromatography. Molecular Therapy - Nucleic Acids, 102333-102333.
• Isoko K, Cordiner JL, Kis Z & Moghadam PZ (2024) Bioprocessing 4.0: a pragmatic review and future perspectives. Digital Discovery. View this article in WRRO
• Welbourne EN, Loveday KA, Nair A, Nourafkan E, Qu J, Cook K, Kis Z & Dickman MJ (2024) Anion exchange HPLC monitoring of mRNA in vitro transcription reactions to support mRNA manufacturing process development. Frontiers in Molecular Biosciences, 11. View this article in WRRO
• Curry E, Muir G, Qu J, Kis Z, Hulley M & Brown A (2024) Engineering an Escherichia coli based in vivo mRNA manufacturing platform. Biotechnology and Bioengineering, 121(6), 1912-1926. View this article in WRRO
• Ibrahim D, Kis Z, Papathanasiou MM, Kontoravdi C, Chachuat B & Shah N (2024) Strategic Planning of a Joint SARS-CoV-2 and Influenza Vaccination Campaign in the UK. Vaccines, 12(2), 158-158.
• Nair A, Loveday KA, Kenyon C, Qu J & Kis Z (2024) Quality by Digital Design for Developing Platform RNA Vaccine and Therapeutic Manufacturing Processes.. Methods Mol Biol, 2786, 339-364.
• Newall AT, Beutels P, Kis Z, Towse A & Jit M (2023) Placing a value on increased flexible vaccine manufacturing capacity for future pandemics. Vaccine.
• Geall AJ, Kis Z & Ulmer JB (2023) Vaccines on demand, part II: future reality. Expert Opinion on Drug Discovery, 18(2), 119-127.
• Daniel S, Kis Z, Kontoravdi C & Shah N (2022) A blueprint for quality by digital design to support rapid RNA vaccine process development, manufacturing & supply. Vaccine Insights, 01(04), 219-233.
• Palmieri E, Kis Z, Ozanne J, Di Benedetto R, Ricchetti B, Massai L, Carducci M, Oldrini D, Gasperini G, Aruta MG , Rossi O et al (2022) GMMA as an alternative carrier for a glycoconjugate vaccine against Group A Streptococcus. Vaccines, 10(7).
• Ly HH, Daniel S, Soriano SKV, Kis Z & Blakney AK (2022) Optimization of Lipid Nanoparticles for saRNA Expression and Cellular Activation Using a Design-of-Experiment Approach. Molecular Pharmaceutics, 19(6), 1892-1905.
• Daniel S, Kis Z, Kontoravdi C & Shah N (2022) Quality by Design for enabling RNA platform production processes. Trends in Biotechnology. View this article in WRRO
• Rostami F, Kis Z, Koppelaar R, Jiménez L & Pozo C (2022) Comparative sustainability study of energy storage technologies using data envelopment analysis. Energy Storage Materials, 48, 412-438.
• Kis Z, Tak K, Ibrahim D, Papathanasiou MM, Chachuat B, Shah N & Kontoravdi C (2022) Pandemic-response adenoviral vector and RNA vaccine manufacturing. npj Vaccines, 7(1).
• Kis Z (2022) Stability modelling of mRNA vaccine quality based on temperature monitoring throughout the distribution chain. Pharmaceutics, 14(2).
• Ibrahim D, Kis Z, Tak K, Papathanasiou MM, Kontoravdi C, Chachuat B & Shah N (2021) Model-based planning and delivery of mass vaccination campaigns against infectious disease: application to the COVID-19 pandemic in the UK. Vaccines, 9(12). View this article in WRRO
• van de Berg D, Kis Z, Behmer CF, Samnuan K, Blakney AK, Kontoravdi C, Shattock R & Shah N (2021) Quality by design modelling to support rapid RNA vaccine production against emerging infectious diseases. npj Vaccines, 6(1). View this article in WRRO
• Kis Z (2021) Enhancing vaccine platforms : computational models accelerate development, manufacturing, and distribution. BioProcess International. View this article in WRRO
• Kis Z, Kontoravdi C, Shattock R & Shah N (2020) Resources, production scales and time required for producing RNA vaccines for the global pandemic demand. Vaccines, 9(1). View this article in WRRO
• Kis Z, Kontoravdi C, Dey AK, Shattock R & Shah N (2020) Rapid development and deployment of high‐volume vaccines for pandemic response. Journal of Advanced Manufacturing and Processing, 2(3). View this article in WRRO
• Kis Z, Papathanasiou M, Calvo‐Serrano R, Kontoravdi C & Shah N (2019) A model‐based quantification of the impact of new manufacturing technologies on developing country vaccine supply chain performance : a Kenyan case study. Journal of Advanced Manufacturing and Processing, 1(3). View this article in WRRO
• Kis Z, Shattock R, Shah N & Kontoravdi C (2019) Emerging Technologies for Low‐Cost, Rapid Vaccine Manufacture. Biotechnology Journal, 14(7), 1-2.
• Kis Z, Shattock R, Shah N & Kontoravdi C (2019) Emerging technologies for low‐cost, rapid vaccine manufacture. Biotechnology Journal, 14(1). View this article in WRRO
• Koppelaar RHEM, Sule MN, Kis Z, Mensah FK, Wang X, Triantafyllidis C, van Dam KH & Shah N (2018) Framework for WASH sector data improvements in data-poor environments, applied to Accra, Ghana. Water, 10(9). View this article in WRRO
• Kis Z, Pandya N & Koppelaar RHEM (2018) Electricity generation technologies: Comparison of materials use, energy return on investment, jobs creation and CO2 emissions reduction. Energy Policy, 120, 144-157. View this article in WRRO
• Lacroix J, Kis Z, Josupeit R, Schlund F, Stroh-Dege A, Frank-Stöhr M, Leuchs B, Schlehofer J, Rommelaere J & Dinsart C (2018) Preclinical testing of an oncolytic parvovirus in Ewing sarcoma : protoparvovirus H-1 induces apoptosis and lytic infection in vitro but fails to improve survival in vivo. Viruses, 10(6). View this article in WRRO
• Geiss C, Kis Z, Leuchs B, Frank-Stöhr M, Schlehofer J, Rommelaere J, Dinsart C & Lacroix J (2017) Preclinical testing of an oncolytic parvovirus : standard protoparvovirus H-1PV efficiently induces osteosarcoma cell lysis in vitro. Viruses, 9(10). View this article in WRRO
• Kis Z, Rodin T, Zafar A, Lai Z, Freke G, Fleck O, Del Rio Hernandez A, Towhidi L, Pedrigi RM, Homma T & Krams R (2016) Development of a synthetic gene network to modulate gene expression by mechanical forces. Scientific Reports, 6(1). View this article in WRRO
• Towhidi L, Khodadadi D, Maimari N, Pedrigi RM, Ip H, Kis Z, Kwak BR, Petrova TW, Delorenzi M & Krams R (2016) Comparison between direct and reverse electroporation of cells in situ: a simulation study. Physiological Reports, 4(6), e12673-e12673. View this article in WRRO
• Carroll MW, Matthews DA, Hiscox JA, Elmore MJ, Pollakis G, Rambaut A, Hewson R, García-Dorival I, Bore JA, Koundouno R , Abdellati S et al (2015) Temporal and spatial analysis of the 2014–2015 Ebola virus outbreak in West Africa. Nature, 524(7563), 97-101.
• Kis Z, Pereira HS, Homma T, Pedrigi RM & Krams R (2015) Mammalian synthetic biology: emerging medical applications. Journal of The Royal Society Interface, 12(106), 20141000-20141000. View this article in WRRO
• Sarkadi J, Jankovics M, Fodor K, Kis Z, Takacs M, Visontai I, Jankovics I & Gonczol E (2015) High-Level Cellular and Humoral Immune Responses in Guinea Pigs Immunized Intradermally with a Heat-Inactivated Varicella-Zoster Virus Vaccine. Clinical and Vaccine Immunology, 22(5), 570-577.
• Towhidi L, Maimari N, Kis Z, Khodadadi D & Krams R (2014) A novel high-throughput platform for siRNA transfection of primary mammalian cells. Atherosclerosis, 237(2), e14-e14.
• Pereyaslov D, Rosin P, Palm D, Zeller H, Gross D, Brown CS, Struelens MJ & on behalf of the MERS-CoV Working Group C (2014) Laboratory capability and surveillance testing for Middle East respiratory syndrome coronavirus infection in the WHO European Region, June 2013. Eurosurveillance, 19(40).
• Frueh J, Maimari N, Lui Y, Kis Z, Mehta V, Pormehr N, Grant C, Chalkias E, Falck-Hansen M, Bovens S , Pedrigi R et al (2012) Systems and synthetic biology of the vessel wall. FEBS Letters, 586(15), 2164-2170. View this article in WRRO
• Kis Z, Makarov SV & Silaghi-Dumitrescu R (2010) Computational investigations on the electronic structure and reactivity of thiourea dioxide: sulfoxylate formation, tautomerism and dioxygen liberation. Journal of Sulfur Chemistry, 31(1), 27-39.
• Szomor KN, Kapusinszky B, Rigó Z, Kis Z, Rózsa M, Farkas Á, Szilágyi A, Berencsi G & Takács M (2009) Detection of Human Bocavirus from Fecal Samples of Hungarian Children with Acute Gastroenteritis. Intervirology, 52(1), 17-21.
• Ménesi D, Kitajka K, Molnár E, Kis Z, Belleger J, Narce M, Kang JX, Puskás LG & Das UN (2009) Gene and protein expression profiling of the fat-1 mouse brain. Prostaglandins, Leukotrienes and Essential Fatty Acids, 80(1), 33-42.
• Kis Z & Silaghi-Dumitrescu R (2009) The electronic structure of biologically relevant Fe(0) systems. International Journal of Quantum Chemistry, NA-NA.
• Makarov SV, Salnikov DS, Pogorelova AS, Kis Z & Silaghi-Dumitrescu R (2008) A new route to carbon monoxide adducts of heme proteins. Journal of Porphyrins and Phthalocyanines, 12(10), 1096-1099.
• Kis Z, Burian K, Treso B, Acs K, Prohaszka Z, Fust G, Gonczol E & Endresz V (2008) Inflammatory- and immune responses in relation to bacterial replication in mice following re-infections with Chlamydophila pneumoniae. Inflammation Research, 57(6), 287-295.
• Kis Z, Treso B, Burian K, Endresz V, Pallinger E, Nagy A, Toth A, Takacs M, Falus A & Gonczol E (2008) Expression of bacterial genes and induction of INF-γ in human myeloid dendritic cells during persistent infection withChlamydophila pneumoniae. FEMS Immunology & Medical Microbiology, 52(3), 324-334.
• Petrovay F, Heltai K, Kis Z, Treso B, Gonczol E, Burian K, Endresz V & Valyi-Nagy I (2007) Chronic infections and histamine, CRP and IL-6 levels after percutaneous transluminal coronary angioplasty. Inflammation Research, 56(9), 362-367.
• Nair A & Kis Z () Bacteriophage RNA polymerases: catalysts for mRNA vaccines and therapeutics. Frontiers in Molecular Biosciences, 11, 1504876.
• Giannelli C, Necchi F, Palmieri E, Oldrini D, Ricchetti B, Papathanasiou MM, Kis Z, Kontoravdi C, Campa C & Micoli F () Quality by Design Framework Applied to GMMA Purification. The AAPS Journal, 26(2).
• Alifia KCH, Kontoravdi C, Kis Z & Ismail D () Techno-Economic Evaluation of Novel SARS-CoV-2 Vaccine Manufacturing in the Insect Cell Baculovirus Platform. International Journal of Technology, 13(8), 1630-1630.
• Kis Z, Kontoravdi C, Shattock R & Shah N () Correction: Kis, Z. et al. Resources, Production Scales and Time Required for Producing RNA Vaccines for the Global Pandemic Demand. Vaccines 2021, 9, 3. Vaccines, 9(3), 205-205.
• Bordi L, Lalle E, Caglioti C, Travaglini D, Lapa D, Marsella P, Quartu S, Kis Z, Arien KK, Huemer HP , Meschi S et al () Antagonistic Antiviral Activity between IFN-Lambda and IFN-Alpha against Lethal Crimean-Congo Hemorrhagic Fever Virus In Vitro. PLOS ONE, 10(2), e0116816-e0116816.
• Gerloff NA, Jones J, Simpson N, Balish A, ElBadry MA, Baghat V, Rusev I, de Mattos CC, de Mattos CA, Zonkle LEA , Kis Z et al () A High Diversity of Eurasian Lineage Low Pathogenicity Avian Influenza A Viruses Circulate among Wild Birds Sampled in Egypt. PLoS ONE, 8(7), e68522-e68522.
• Mot A, Zoltan K, Svistunenko DA, Damian G, Silaghi-Dumitrescu R & Makarov SV () ‘Super-reduced’ iron under physiologically-relevant conditions. Dalton Trans., 39(6), 1464-1466.

Chapters

• Kis Z, Tak K, Ibrahim D, Daniel S, van de Berg D, Papathanasiou MM, Chachuat B, Kontoravdi C & Shah N (2022) Quality by design and techno-economic modelling of RNA vaccine production for pandemic-response, Computer Aided Chemical Engineering (pp. 2167-2172). Elsevier
• Ibrahim D, Kis Z, Tak K, Papathanasiou M, Kontoravdi C, Chachuat B & Shah N (2022) Optimal design and planning of supply chains for viral vectors and RNA vaccines, Computer Aided Chemical Engineering (pp. 1633-1638). Elsevier
• Pereira GC, Malik S, Kis Z & Rocamonde B (2019) Computationally Designed Recombinant-DNA-Based Compounds Production Driven in Plants During Secondary Metabolism and Their Implication in Antimalarial Therapies, Natural Bio-active Compounds (pp. 127-146). Springer Singapore
• Kis Z, Towhidi L, Ip H, Drakakis E, Bharath A & Krams R (2014) An In situ electroporation and flow device for mechanotransduction studies, Microarrays: Principles, Applications and Technologies (pp. 49-67).

Preprints

• Amurri L, Dumont C, Pelissier R, Reynard O, Mathieu C, Spanier J, Pályi B, Deri D, Karkowski L, Skerra J , Kis Z et al (2024) Multifaceted activation of STING axis upon Nipah and Measles virus-induced syncytia formation, Research Square Platform LLC.
• Curry E, Muir G, Qu J, Kis Z, Hulley M & Brown A (2023) Engineering an E. coli -based in vivo mRNA manufacturing platform, Authorea, Inc..
• Máthé D, Szalay G, Cseri L, Kis Z, Pályi B, Földes G, Kovács N, Fülöp A, Szepesi Á, Hajdrik P , Csomos A et al (2022) Monitoring correlates of SARS-CoV-2 infection in cell culture using two-photon microscopy and a novel fluorescent calcium-sensitive dye, Cold Spring Harbor Laboratory.
• Kis Z, Tak K, Ibrahim D, Papathanasiou MM, Chachuat B, Shah N & Kontoravdi C (2021) Pandemic-response adenoviral vector and RNA vaccine manufacturing, Cold Spring Harbor Laboratory.
• Hajdrik P, Pályi B, Kis Z, Kovács N, Veres DS, Szigeti K, Hegedűs I, Kovács T, Bergmann R & Máthé D (2021) In vitro determination of inhibitory effects by humic substances complexing Zn and Se on SARS-CoV-2 virus replication, Cold Spring Harbor Laboratory.
• Kiss B, Kis Z, Pályi B & Kellermayer MSZ (2020) Topography, spike dynamics and nanomechanics of individual native SARS-CoV-2 virions, Cold Spring Harbor Laboratory.