Professor Peter Andrews

School of Biosciences

Emeritus Professor

p.w.andrews@sheffield.ac.uk
+44 114 222 4173

E, Alfred Denny Building

Full contact details

Professor Peter Andrews
School of Biosciences
E
Alfred Denny Building
Western Bank
Sheffield
S10 2TN

Profile

School of Biosciences (formerly the Department of Biomedical Science), the University of Sheffield

Arthur Jackson Professor of Biomedical Science: 1992-present
Chairman of Department 1995-2003

The Wistar Institute of Anatomy and Biology, Philadelphia

Associate Professor: 1991-1992
Assistant Professor: 1983-1990
Research Associate: 1980-1982
Research Investigator: 1978-1979

Sloan-Kettering Institute, New York

Research Fellow: 1976-1978

Institut Pasteur, Paris

Research Fellow: 1974-1975

Research interests

The Biology of human Embryonic Stem Cells and their Malignant counterparts from Teratocarcinomas.

The Biology of Human Pluripotent Stem Cell Fate Determinations

Human embryonic stem cells (HESCs) are derived from the inner cell mass of the early embryo; the cells are genetically normal and retain in vitro both the ability to self renew and also to differentiate into each of the cell types found in the adult body. Such a system offers an in vitro model of human embryogenesis. Thus, a powerful resource now exists for the investigation of human developmental biology, the testing of candidate drugs for toxicology and efficacy and ultimately, tissue engineering for regenerative medicine.

The sensitivity of HESCs to biologically active factors and their developmental plasticity are attributes that confer upon them such great potential, but also present significant obstacles to their exploitation.

Many of these issues derive from an inadequate understanding of how HESCs regulate their self renewal and commitment to differentiation, and how these processes may be affected by the environment in which the cells are maintained.

Adaptation of Human embryonic Stem Cells to in vitro culture

In human ES cells, after prolonged culture, repetitive karyotypic changes have been noted (1, 2). These repetitive karyotypic changes are strikingly similar to the karyotypic abnormalities observed in Embryonal Carcinoma (EC) cells, which are the malignant stem cells of germ cell tumours.

Culture adapted ES cells may also show higher proliferative and cloning ability than their `normal´ early passage counterparts. Pluripotent ES cells in culture are subject to continual selection for genetic variants that increase the probability of `self-renewal´ and decrease the probability of differentiation or apoptosis. It also seems likely that EC cells in germ cell tumours are subject to similar selection pressures. Thus understanding the nature of the karyotypic and other genetic changes that occur in human ES cells in culture may give insights, not only into the genetic and molecular mechanisms that control self-renewal and commitment in these cells, but also give insights into the processes of cancer development and progression in germ cell tumours.

Embryonal Carcinoma (EC) Cells and Germ Cell Tumours

EC cells are the malignant stem cells of teratocarcinomas, a subset of germ cell tumours which occur predominantly as testicular cancers and are the most common cancers of young men. (3). EC cells are malignant counterparts of ES cells derived from human blastocysts. Human EC cells share some features in common with mouse ES and EC cells (e.g. expression of the transcription factors Oct4 and Nanog, and high levels of alkaline phosphatase) but they differ in other respects such as their distinct patterns of surface marker antigen expression. Neverthelesss, just as mouse EC and ES cells resemble the inner cell mass cells of the early mouse embryo at the blastocyst stage, so human EC cells resemble human ES cells and inner cell mass cells of early human blastocysts (4).

Over many years we have used EC cell lines as surrogates for the study of plurotent human ES cells and have used them to define a series of marker antigens for defining the undifferentiated EC phenotype (5) and for monitoring differentiation (6). These antigens are now widely used in the study of human ES cells (7). Human EC cell lines also remain relatively simple models for further studies with ES cells, since they can readily be grown in large numbers without the need for feeder cells or expensive media additives. Widely used lines include relatively nullipotent lines such as 2102Ep, useful in defining the phenotype of undifferentiated human EC and ES cells, and NTERA2 which differentiates extensively into neurons and other cells types when induced by agents such as retinoic acid (8). Studies in NTERA2 provided the first evidence of the dosage dependence of retinoic acid induction of HOX gene expression, in a way that appears to reflect the pattern of HOX gene expression along the anterior posterior axis of the developing embryo (9). In a different area of research, differentiatial susceptibility of undifferentiated and differentiated NTERA2 EC cells to replication of human cytomegalovirus (HCMV) and human immunodeficiency virus (HIV) provides tools for investigating the interaction of these pathogenic viruses with human cells (10, 11).

Signalling pathways that contribute to the self-renewal and differentiation of human embryonic stem cells

Multiple signalling pathways contribute to maintenance of the undifferentiated state of ES cells and to controlling their commitment to differentiation. Relatively little is known about how specific pathways interact with each other in ES cells, but it is becoming evident that the relative importance of particular pathways may differ substantially between mouse and human ES cells. We are currently using a variety of approaches, including comparative studies of `normal´ and `adapted´ ES cells, as well as studies of human EC cells to identify particular signalling systems that contribute to self renewal and differentiation in human ES cells. Our specific areas of interest include the Notch and Wnt pathways as well as the role of TGFbeta superfamily members. Our techniques include the use of RNAi to modulate gene expression Using the latter technique , for exampole, we demomnstrated that, indeed, human EC and ES cells require the expression of Oct4 to maintain their undifferentiated state and that if its expression is knocked-down, differentiation towards trophectoderm ensues (12).

Differentiation of Human ES cells

Pluripotency of human ES cells is their property that offers such great potential for future applications. Human ES cells will spontaneously differentiate into a wide range of cell types but this process is difficult to control. Eventual applications will depend on understanding the mechanisms that control lineage selection once the cells commit to differentiate and developing protocols to make use of that knowledge. In our group we are specifically focussing on the mechanisms that regulate neural differentiation and differentiation toward pancreatic cells. Eventually these cell types could be used in regenerative medicine to treat a range of neurodegenerative diseases and diabetes. However, it is important to recognise that considerable research and development will be necessary before these goals can be realised.

The Centre for Stem Cell Biology

The Centre for Stem Cell Biology (CSCB), directed by Professors Peter W Andrews and Harry D Moore, brings together researchers in the University of Sheffield interested in the biology of human ES cells and in developing applications that involve these cells. Within the CSCB, we have derived six new human ES cell lines and are building a new cGMP facility that will enable us to derive new lines in the future to meet standards required for their future clinical applications. The CSCB also runs an annual training course in the culture of human ES cells, and can provide assistance to others who wish to establish human ES cell research in their own laboratories. For this we have specific funding from the MRC to operate a `Human ES Cell Resesource Centre´ to assist development of human ES cell research throughout the UK. As well as a variety of human ES cell lines, we also maintain various facilities such as a recently installed state-of-the-art Dakocytomation cell sorter.

The International Stem Cell Initiative (ISCI)

The ISCI is a study being carried out under the auspices of the International Stem Cell Forum. It includes a comparative study of surface antigen markers and gene expression patterns of up to 75 human ES cell lines from some 15 laboratories and 10 countries worldwide (13). It is expected to complete its work and issue a report by the end of 2005.

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Thompson O, von Meyenn F, Hewitt Z, Alexander J, Wood A, Weightman R, Gregory S, Krueger F, Andrews S, Barbaric I , Gokhale PJ et al (2020) Low rates of mutation in clinical grade human pluripotent stem cells under different culture conditions. Nature Communications, 11(1). View this article in WRRO
Allison TF, Smith AJH, Anastassiadis K, Sloane-Stanley J, Biga V, Stavish D, Hackland J, Sabri S, Langerman J, Jones M , Plath K et al (2018) Identification and Single-Cell Functional Characterization of an Endodermally Biased Pluripotent Substate in Human Embryonic Stem Cells. Stem Cell Reports, 10(6), 1895-1907. View this article in WRRO
Allison TF, Andrews PW, Avior Y, Barbaric I, Benvenisty N, Bock C, Brehm J, Bruestle O, Damjanov I, Elefanty A , Felkner D et al (2018) Assessment of established techniques to determine developmental and malignant potential of human pluripotent stem cells. Nature Communications, 9. View this article in WRRO
Hackland JOS, Frith TJR, Thompson O, Marin Navarro A, Garcia-Castro MI, Unger C & Andrews PW (2017) Top-Down Inhibition of BMP Signaling Enables Robust Induction of hPSCs Into Neural Crest in Fully Defined, Xeno-free Conditions. Stem Cell Reports, 9(4), 1043-1052. View this article in WRRO
Andrews PW, Ben-David U, Benvenisty N, Coffey P, Eggan K, Knowles BB, Nagy A, Pera M, Reubinoff B, Rugg-Gunn PJ & Stacey GN (2017) Assessing the Safety of Human Pluripotent Stem Cells and Their Derivatives for Clinical Applications. Stem Cell Reports, 9(1), 1-4. View this article in WRRO
Baker D, Hirst AJ, Gokhale PJ, Juarez MA, Williams S, Wheeler M, Bean K, Allison TF, Moore HD, Andrews PW & Barbaric I (2016) Detecting Genetic Mosaicism in Cultures of Human Pluripotent Stem Cells.. Stem Cell Reports, 7(5), 998-1012. View this article in WRRO
Burns AJ, Goldstein AM, Newgreen DF, Stamp L, Schäfer K-H, Metzger M, Hotta R, Young HM, Andrews PW, Thapar N , Belkind-Gerson J et al (2016) White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies. Developmental Biology, 417(2), 229-251. View this article in WRRO
Damjanov I & Andrews PW (2016) Teratomas produced from human pluripotent stem cells xenografted into immunodeficient mice - a histopathology atlas. The International Journal of Developmental Biology, 60(10-11-12), 337-419. View this article in WRRO
Gokhale PJ, Au-Young JK, Dadi S, Keys DN, Harrison NJ, Jones M, Soneji S, Enver T, Sherlock JK & Andrews PW (2015) Culture Adaptation Alters Transcriptional Hierarchies among Single Human Embryonic Stem Cells Reflecting Altered Patterns of Differentiation. PLoS ONE, 10(4). View this article in WRRO
Barbaric I, Biga V, Gokhale PJ, Jones M, Stavish D, Glen A, Coca D & Andrews PW (2014) Time-Lapse Analysis of Human Embryonic Stem Cells Reveals Multiple Bottlenecks Restricting Colony Formation and Their Relief upon Culture Adaptation. Stem Cell Reports, 3(1), 142--155. View this article in WRRO
Avery S, Hirst AJ, Baker D, Lim CY, Alagaratnam S, Skotheim RI, Lothe RA, Pera MF, Colman A, Robson P , Andrews PW et al (2013) BCL-XL mediates the strong selective advantage of a 20q11.21 amplification commonly found in human embryonic stem cell cultures. Stem Cell Reports, 1(5), 379-386. View this article in WRRO
Desmarais JA, Hoffmann MJ, Bingham G, Gagou ME, Meuth M & Andrews PW (2012) Human embryonic stem cells fail to activate CHK1 and commit to apoptosis in response to DNA replication stress.. Stem Cells, 30(7), 1385-1393.
International Stem Cell Initiative , Amps K, Andrews PW, Anyfantis G, Armstrong L, Avery S, Baharvand H, Baker J, Baker D, Munoz MB , Beil S et al (2011) Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage.. Nat Biotechnol, 29(12), 1132-1144.
Tonge PD, Shigeta M, Schroeder T & Andrews PW (2011) Functionally defined substates within the human embryonic stem cell compartment.. Stem Cell Res, 7(2), 145-153.
Avery S, Zafarana G, Gokhale PJ & Andrews PW (2010) The role of SMAD4 in human embryonic stem cell self-renewal and stem cell fate.. Stem Cells, 28(5), 863-873.
Olariu V, Harrison NJ, Coca D, Gokhale PJ, Baker D, Billings S, Kadirkamanathan V & Andrews PW (2010) Modeling the evolution of culture-adapted human embryonic stem cells.. Stem Cell Res, 4(1), 50-56.
Tonge PD, Olariu V, Coca D, Kadirkamanathan V, Burrell KE, Billings SA & Andrews PW (2010) Prepatterning in the stem cell compartment.. PLoS One, 5(5), e10901. View this article in WRRO
Enver T, Pera M, Peterson C & Andrews PW (2009) Stem Cell States, Fates, and the Rules of Attraction. CELL STEM CELL, 4(5), 387-397.
Zafarana G, Avery SR, Avery K, Moore HD & Andrews PW (2009) Specific knockdown of OCT4 in human embryonic stem cells by inducible short hairpin RNA interference.. Stem Cells, 27(4), 776-782. View this article in WRRO
Atlasi Y, Mowla SJ, Ziaee SAM, Gokhale PJ & Andrews PW (2008) OCT4 spliced variants are differentially expressed in human pluripotent and nonpluripotent cells.. Stem Cells, 26(12), 3068-3074.
Vugler A, Lawrence J, Walsh J, Carr A, Gias C, Semo M, Ahmado A, da Cruz L, Andrews P & Coffey P (2007) Embryonic stem cells and retinal repair. Mechanisms of Development, 124(11-12), 807-829.
Damjanov I & Andrews PW (2007) The terminology of teratocarcinomas and teratomas. NAT BIOTECHNOL, 25(11), 1212-1212.
International Stem Cell Initiative , Adewumi O, Aflatoonian B, Ahrlund-Richter L, Amit M, Andrews PW, Beighton G, Bello PA, Benvenisty N, Berry LS , Bevan S et al (2007) Characterization of human embryonic stem cell lines by the International Stem Cell Initiative.. Nat Biotechnol, 25(7), 803-816.
Frith TJR, Granata I, Stout E, Wind M, Thompson O, Neumann K, Stavish D, Heath PR, Hackland JOS, Anastassiadis K , Gouti M et al () Human axial progenitors generate trunk neural crest cells. View this article in WRRO

Chapters

Hackland JOS, Frith TJR & Andrews PW (2019) Fully Defined and Xeno-Free Induction of hPSCs into Neural Crest Using Top-Down Inhibition of BMP Signaling, Methods in Molecular Biology (pp. 49-54). Springer New York

All publications

Journal articles

Andrews PW (2024) Germ cell tumors, cell surface markers, and the early search for human pluripotent stem cells. BioEssays, e2400094.
Jevans B, Cooper F, Fatieieva Y, Gogolou A, Kang Y-N, Restuadi R, Moulding D, Vanden Berghe P, Adameyko I, Thapar N , Andrews PW et al (2024) Human enteric nervous system progenitor transplantation improves functional responses in Hirschsprung disease patient-derived tissue. Gut. View this article in WRRO
Andrews PW & Gokhale PJ (2023) A short history of pluripotent stem cells markers. Stem Cell Reports.
Ludwig TE, Andrews PW, Barbaric I, Benvenisty N, Bhattacharyya A, Crook JM, Daheron LM, Draper JS, Healy LE, Huch M , Inamdar MS et al (2023) ISSCR standards for the use of human stem cells in basic research. Stem Cell Reports, 18(9), 1744-1752.
Saldana-Guerrero IM, Montano-Gutierrez LF, Hafemeister C, Stavish D, Shaw LE, Fetahu IS, Wenninger-Weinzierl A, Sturtzel C, Souilhol C, Tarelli S , Shoeb MR et al (2023) Abstract 3542: A stem cell model dissects detrimental effects of neuroblastoma-linked chromosomal aberrations on cell differentiation during neural crest development. Cancer Research, 83(7_Supplement), 3542-3542.
Pridgeon CS, Forootan SS, Zhang F, Harper N, Palmer D, Weightmann R, Gregory S, Hewitt Z, Baker D, Halliwell J , Moore H et al (2023) In Vivo Tumorigenicity of the 20q11.21 Amplicon in an Engraftment Model of hPSCs and Differentiated Liver Cells. JOURNAL OF STEM CELLS & REGENERATIVE MEDICINE, 19(1), P2-P12.
Andrews PW, Barbaric I, Benvenisty N, Draper JS, Ludwig T, Merkle FT, Sato Y, Spits C, Stacey GN, Wang H & Pera MF (2022) The consequences of recurrent genetic and epigenetic variants in human pluripotent stem cells. Cell Stem Cell, 29(12), 1624-1636.
Abu-Dawud R, Mistry BV, Almahdali R, Matin MM, Alaiya A, Alghamdi F, Alamari H, Al-Yacoub N, Kashir J, Houssein M , Alawad A et al (2022) Dynamic Cytosolic Foci of DPPA4 in Human Pluripotent Stem Cells. Tissue and Cell, 101893-101893.
Andrews PW (2021) Human pluripotent stem cells: tools for regenerative medicine. Biomaterials Translational, 2(4), 294-300. View this article in WRRO
Halliwell J, Baker D, Judge K, Quail MA, Oliver K, Betteridge E, Skelton J, Andrews PW & Barbaric I (2021) Nanopore sequencing indicates that tandem amplification of chromosome 20q11.21 in human pluripotent stem cells is driven by break induced replication. Stem Cells and Development. View this article in WRRO
Andrews PW (2021) Human pluripotent stem cells : genetic instability or stability?. Regenerative Medicine, 16(2), 113-115.
Wind M, Gogolou A, Manipur I, Granata I, Butler L, Andrews PW, Barbaric I, Ning K, Guarracino MR, Placzek M & Tsakiridis A (2021) Defining the signalling determinants of a posterior ventral spinal cord identity in human neuromesodermal progenitor derivatives. Development, 148(6). View this article in WRRO
Thompson O, von Meyenn F, Hewitt Z, Alexander J, Wood A, Weightman R, Gregory S, Krueger F, Andrews S, Barbaric I , Gokhale PJ et al (2020) Low rates of mutation in clinical grade human pluripotent stem cells under different culture conditions. Nature Communications, 11(1). View this article in WRRO
Halliwell J, Barbaric I & Andrews PW (2020) Acquired genetic changes in human pluripotent stem cells : origins and consequences. Nature Reviews Molecular Cell Biology, 21(12), 715-728.
Stavish D, Böiers C, Price C, Frith TJR, Halliwell J, Saldaña-Guerrero I, Wray J, Brown J, Carr J, James C , Barbaric I et al (2020) Generation and trapping of a mesoderm biased state of human pluripotency. Nature Communications, 11.
Hoff AM, Kraggerud SM, Alagaratnam S, Berg KCG, Johannessen B, Høland M, Nilsen G, Lingjærde OC, Andrews PW, Lothe RA & Skotheim RI (2020) Frequent copy number gains of SLC2A3 and ETV1 in testicular embryonal carcinomas. Endocrine-Related Cancer, 27(9), 457-468. View this article in WRRO
Frith TJR, Gogolou A, Hackland JOS, Hewitt ZA, Moore HD, Barbaric I, Thapar N, Burns AJ, Andrews PW, Tsakiridis A & McCann CJ (2020) Retinoic acid accelerates the specification of enteric neural progenitors from in-vitro-derived neural crest. Stem Cell Reports.
Halliwell JA, Frith TJR, Laing O, Price CJ, Bower OJ, Stavish D, Gokhale PJ, Hewitt Z, El-Khamisy SF, Barbaric I & Andrews PW (2020) Nucleosides rescue replication-mediated genome instability of human pluripotent stem cells. Stem Cell Reports, 14(6), 1009-1017. View this article in WRRO
Zhang J, Hirst AJ, Duan F, Qiu H, Huang R, Ji Y, Bai L, Zhang F, Robinson D, Jones M , Li L et al (2019) Anti-apoptotic Mutations Desensitize Human Pluripotent Stem Cells to Mitotic Stress and Enable Aneuploid Cell Survival. Stem Cell Reports, 12(3), 557-571. View this article in WRRO
Stacey GN, Andrews P, Barbaric I, Boiers C, Chandra A, Cossu G, Csontos L, Frith TJR, Halliwell JA, Hewitt Z , McCall M et al (2019) Stem cell culture conditions and stability: a joint workshop of the PluriMes Consortium and Pluripotent Stem Cell Platform. Regenerative medicine, 14(3), 243-255. View this article in WRRO
Stacey G, Andrews P, Asante C, Barbaric I, Barry J, Bisset L, Braybrook J, Buckle R, Chandra A, Coffey P , Crouch S et al (2018) Science-based assessment of source materials for cell-based medicines: report of a stakeholders workshop. Regenerative Medicine, 13(8), 935-944. View this article in WRRO
Allison TF, Smith AJH, Anastassiadis K, Sloane-Stanley J, Biga V, Stavish D, Hackland J, Sabri S, Langerman J, Jones M , Plath K et al (2018) Identification and Single-Cell Functional Characterization of an Endodermally Biased Pluripotent Substate in Human Embryonic Stem Cells. Stem Cell Reports, 10(6), 1895-1907. View this article in WRRO
Allison TF, Andrews PW, Avior Y, Barbaric I, Benvenisty N, Bock C, Brehm J, Bruestle O, Damjanov I, Elefanty A , Felkner D et al (2018) Assessment of established techniques to determine developmental and malignant potential of human pluripotent stem cells. Nature Communications, 9. View this article in WRRO
Kyriakides O, Halliwell JA & Andrews PW (2017) Acquired Genetic and Epigenetic Variation in Human Pluripotent Stem Cells.. Advances in Biochemical Engineering Biotechnology. View this article in WRRO
Hackland JOS, Frith TJR, Thompson O, Marin Navarro A, Garcia-Castro MI, Unger C & Andrews PW (2017) Top-Down Inhibition of BMP Signaling Enables Robust Induction of hPSCs Into Neural Crest in Fully Defined, Xeno-free Conditions. Stem Cell Reports, 9(4), 1043-1052. View this article in WRRO
Andrews PW, Ben-David U, Benvenisty N, Coffey P, Eggan K, Knowles BB, Nagy A, Pera M, Reubinoff B, Rugg-Gunn PJ & Stacey GN (2017) Assessing the Safety of Human Pluripotent Stem Cells and Their Derivatives for Clinical Applications. Stem Cell Reports, 9(1), 1-4. View this article in WRRO
Baker D, Hirst AJ, Gokhale PJ, Juarez MA, Williams S, Wheeler M, Bean K, Allison TF, Moore HD, Andrews PW & Barbaric I (2016) Detecting Genetic Mosaicism in Cultures of Human Pluripotent Stem Cells.. Stem Cell Reports, 7(5), 998-1012. View this article in WRRO
Burns AJ, Goldstein AM, Newgreen DF, Stamp L, Schäfer K-H, Metzger M, Hotta R, Young HM, Andrews PW, Thapar N , Belkind-Gerson J et al (2016) White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies. Developmental Biology, 417(2), 229-251. View this article in WRRO
Damjanov I & Andrews PW (2016) Teratomas produced from human pluripotent stem cells xenografted into immunodeficient mice - a histopathology atlas. The International Journal of Developmental Biology, 60(10-11-12), 337-419. View this article in WRRO
Andrews PW & Elvassore N (2016) The origins of stem cells as tools for regenerative medicine. Biochemical and Biophysical Research Communications, 473(3), 663-664.
Desmarais JA, Unger C, Damjanov I, Meuth M & Andrews P (2016) Apoptosis and failure of checkpoint kinase 1 activation in human induced pluripotent stem cells under replication stress. Stem Cell Research and Therapy, 7(1), 17-17. View this article in WRRO
Damjanov I & Andrews PW (2016) Pluripotent human stem cells: Standing on the shoulders of giants. International Journal of Developmental Biology, 60(10-12), 321-325. View this article in WRRO
Hoff AM, Alagaratnam S, Zhao S, Bruun J, Andrews PW, Lothe RA & Skotheim RI (2016) Identification of Novel Fusion Genes in Testicular Germ Cell Tumors. American Journal of Cancer, 76(1), 108-116. View this article in WRRO
Jones AJ, Gokhale PJ, Allison TF, Sampson B, Athwal S, Grant S, Andrews PW, Allen ND & Patrick Case C (2015) Evidence for bystander signalling between human trophoblast cells and human embryonic stem cells. Scientific Reports, 5(1). View this article in WRRO
Gokhale PJ, Au-Young JK, Dadi S, Keys DN, Harrison NJ, Jones M, Soneji S, Enver T, Sherlock JK & Andrews PW (2015) Culture Adaptation Alters Transcriptional Hierarchies among Single Human Embryonic Stem Cells Reflecting Altered Patterns of Differentiation. PLoS ONE, 10(4). View this article in WRRO
Andrews PW, Baker D, Benvinisty N, Miranda B, Bruce K, Brüstle O, Choi M, Choi Y-M, Crook JM, de Sousa PA , Dvorak P et al (2015) Points to consider in the development of seed stocks of pluripotent stem cells for clinical applications: International Stem Cell Banking Initiative (ISCBI). Regenerative Medicine, 10(2s), 1-44.
Heslop JA, Hammond TG, Santeramo I, Tort Piella A, Hopp I, Zhou J, Baty R, Graziano EI, Proto Marco B, Caron A , Sköld P et al (2015) Concise Review: Workshop Review: Understanding and Assessing the Risks of Stem Cell-Based Therapies. STEM CELLS Translational Medicine, 4(4), 389-400.
Heslop JA, Hammond TG, Santeramo I, Piella AT, Hopp I, Zhou J, Baty R, Graziano EI, Marco BP, Caron A , Sköld P et al (2015) Concise review: Workshop review: Understanding and assessing the risks of stem cell-based therapies. Stem Cells Translational Medicine, 4(4), 389-400.
Ben-David U, Arad G, Weissbein U, Mandefro B, Maimon A, Golan-Lev T, Narwani K, Clark AT, Andrews PW, Benvenisty N & Carlos Biancotti J (2014) Aneuploidy induces profound changes in gene expression, proliferation and tumorigenicity of human pluripotent stem cells. Nature Communications, 5(1).
Sutiwisesak R, Kitiyanant N, Kotchabhakdi N, Felsenfeld G, Andrews PW & Wongtrakoongate P (2014) Induced pluripotency enables differentiation of human nullipotent embryonal carcinoma cells N2102Ep. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1843(11), 2611-2619.
Andrews PW, Cavagnaro J, Deans R, Feigal E, Horowitz E, Keating A, Rao M, Turner M, Wilmut I & Yamanaka S (2014) Harmonizing standards for producing clinical-grade therapies from pluripotent stem cells. Nature Biotechnology, 32(8), 724-726.
Na J, Baker D, Zhang J, Andrews PW & Barbaric I (2014) Aneuploidy in pluripotent stem cells and implications for cancerous transformation.. Protein Cell, 5(8), 569-579. View this article in WRRO
Barbaric I, Biga V, Gokhale PJ, Jones M, Stavish D, Glen A, Coca D & Andrews PW (2014) Time-Lapse Analysis of Human Embryonic Stem Cells Reveals Multiple Bottlenecks Restricting Colony Formation and Their Relief upon Culture Adaptation. Stem Cell Reports, 3(1), 142--155. View this article in WRRO
Allison T, Powles-Glover NS, Stewart J & Andrews PW (2014) A Novel Human Embryoid Body System (hEB) with Potential to Be Used for Screening Drug Candidates in the Field of Reproductive Toxicology. BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY, 100(5), 405-405.
Isasi R, Andrews PW, Baltz JM, Bredenoord AL, Burton P, Chiu I-M, Hull SC, Jung J-W, Kurtz A, Lomax G , Ludwig T et al (2014) Identifiability and privacy in pluripotent stem cell research.. Cell Stem Cell, 14(4), 427-430.
Wongtrakoongate P, Li J & Andrews PW (2014) Aza-deoxycytidine induces apoptosis or differentiation via DNMT3B and targets embryonal carcinoma cells but not their differentiated derivatives. British Journal of Cancer.
Andrews PW, Cavanagro J, Deans R, Feigel E, Horowitz E, Keating A, Rao M, Turner M, Wilmut I & Yamanaka S (2014) Erratum: Corrigendum: Harmonizing standards for producing clinical-grade therapies from pluripotent stem cells. Nature Biotechnology, 32(11), 1166-1166.
Wongtrakoongate P, Li J & Andrews PW (2014) DNMT3B inhibits the re-expression of genes associated with induced pluripotency.. Exp Cell Res, 321(2), 231-239.
Avery S, Hirst AJ, Baker D, Lim CY, Alagaratnam S, Skotheim RI, Lothe RA, Pera MF, Colman A, Robson P , Andrews PW et al (2013) BCL-XL mediates the strong selective advantage of a 20q11.21 amplification commonly found in human embryonic stem cell cultures. Stem Cell Reports, 1(5), 379-386. View this article in WRRO
Gokhale PJ & Andrews PW (2013) Characterization of human pluripotent stem cells.. Neuroreport, 24(18), 1031-1034.
Kong L, Aho KL, Granberg K, Lund R, Järvenpää L, Seppälä J, Gokhale P, Leinonen K, Hahne L, Mäkelä J , Laurila K et al (2013) ESTOOLS Data@Hand: human stem cell gene expression resource. Nature Methods, 10(9), 814-815.
Lund RJ, Emani MR, Barbaric I, Kivinen V, Jones M, Baker D, Gokhale P, Nykter M, Lahesmaa R & Andrews PW (2013) Karyotypically abnormal human ESCs are sensitive to HDAC inhibitors and show altered regulation of genes linked to cancers and neurological diseases.. Stem Cell Res, 11(3), 1022-1036.
Alagaratnam S, Harrison N, Bakken AC, Hoff AM, Jones M, Sveen A, Moore HD, Andrews PW, Lothe RA & Skotheim RI (2013) Transforming pluripotency: An exon-level study of malignancy-specific transcripts in human embryonal carcinoma and embryonic stem cells. Stem Cells and Development, 22(7), 1136-1146.
Draper JS & Andrews PW (2013) Surface Antigen Markers, 1, 375-382.
Johnson P & Andrews PW (2013) Cell Fusion and the Differentiated State, 1, 89-94.
Wongtrakoongate P, Jones M, Gokhale PJ & Andrews PW (2013) STELLA facilitates differentiation of germ cell and endodermal lineages of human embryonic stem cells.. PLoS One, 8(2), e56893. View this article in WRRO
Lund RJ, Nikula T, Rahkonen N, Närvä E, Baker D, Harrison N, Andrews P, Otonkoski T & Lahesmaa R (2012) High-throughput karyotyping of human pluripotent stem cells. Stem Cell Research, 9(3), 192-195.
Chen W, Jongkamonwiwat N, Abbas L, Eshtan SJ, Johnson SL, Kuhn S, Milo M, Thurlow JK, Andrews PW, Marcotti W , Moore HD et al (2012) Restoration of auditory evoked responses by human ES-cell-derived otic progenitors.. Nature, 490(7419), 278-282. View this article in WRRO
Gokhale PJ & Andrews PW (2012) The development of pluripotent stem cells.. Curr Opin Genet Dev, 22(5), 403-408.
Hyka-Nouspikel N, Desmarais J, Gokhale PJ, Jones M, Meuth M, Andrews PW & Nouspikel T (2012) Deficient DNA damage response and cell cycle checkpoints lead to accumulation of point mutations in human embryonic stem cells.. Stem Cells, 30(9), 1901-1910.
Desmarais JA, Hoffmann MJ, Bingham G, Gagou ME, Meuth M & Andrews PW (2012) Human embryonic stem cells fail to activate CHK1 and commit to apoptosis in response to DNA replication stress.. Stem Cells, 30(7), 1385-1393.
Isasi R, Knoppers BM, Andrews PW, Bredenoord A, Colman A, Hin LE, Hull S, Kim OJ, Lomax G, Morris C , Sipp D et al (2012) Disclosure and management of research findings in stem cell research and banking: Policy statement. Regenerative Medicine, 7(3), 439-448.
International Stem Cell Initiative , Amps K, Andrews PW, Anyfantis G, Armstrong L, Avery S, Baharvand H, Baker J, Baker D, Munoz MB , Beil S et al (2011) Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage.. Nat Biotechnol, 29(12), 1132-1144.
Sood A, Salih S, Roh D, Lacharme-Lora L, Parry M, Hardiman B, Keehan R, Grummer R, Winterhager E, Gokhale PJ , Andrews PW et al (2011) Signalling of DNA damage and cytokines across cell barriers exposed to nanoparticles depends on barrier thickness.. Nat Nanotechnol, 6(12), 824-833.
Barbaric I, Jones M, Buchner K, Baker D, Andrews PW & Moore HD (2011) Pinacidil enhances survival of cryopreserved human embryonic stem cells.. Cryobiology, 63(3), 298-305.
Tonge PD, Shigeta M, Schroeder T & Andrews PW (2011) Functionally defined substates within the human embryonic stem cell compartment.. Stem Cell Res, 7(2), 145-153.
Goldring CEP, Duffy PA, Benvenisty N, Andrews PW, Ben-David U, Eakins R, French N, Hanley NA, Kelly L, Kitteringham NR , Kurth J et al (2011) Assessing the Safety of Stem Cell Therapeutics. Cell Stem Cell, 9(2), 176-176.
Wright A, Andrews N, Bardsley K, Nielsen JE, Avery K, Pewsey E, Jones M, Harley D, Nielsen AR, Moore H , Gokhale P et al (2011) Mapping the stem cell state: eight novel human embryonic stem and embryonal carcinoma cell antibodies.. Int J Androl, 34(4 Pt 2), e175-e187.
Barbaric I, Jones M, Harley DJ, Gokhale PJ & Andrews PW (2011) High-content screening for chemical modulators of embryonal carcinoma cell differentiation and survival.. J Biomol Screen, 16(6), 603-617.
Barbaric I, Jones M, Buchner K, Baker D, Andrews PW & Moore HD (2011) Pinacidil enhances survival of cryopreserved human embryonic stem cells. Cryobiology, 63(3), 298-305.
Goldring CEP, Duffy PA, Benvenisty N, Andrews PW, Ben-David U, Eakins R, French N, Hanley NA, Kelly L, Kitteringham NR , Kurth J et al (2011) Assessing the safety of stem cell therapeutics. Cell Stem Cell, 8(6), 618-628.
Andrews PW (2011) Toward safer regenerative medicine.. Nat Biotechnol, 29(9), 803-805.
Fazeli A, Liew C-G, Matin MM, Elliott S, Jeanmeure LFC, Wright PC, Moore H & Andrews PW (2011) Altered patterns of differentiation in karyotypically abnormal human embryonic stem cells.. Int J Dev Biol, 55(2), 175-180.
Na J, Plews J, Li J, Wongtrakoongate P, Tuuri T, Feki A, Andrews PW & Unger C (2010) Molecular mechanisms of pluripotency and reprogramming. Stem Cell Research and Therapy, 1(4). View this article in WRRO
Calvanese V, Lara E, Suarez-Alvarez B, Abu Dawud R, Vazquez-Chantada M, Martinez-Chantar ML, Embade N, Lopez-Nieva P, Horrillo A, Hmadcha A , Soria B et al (2010) Sirtuin 1 regulation of developmental genes during differentiation of stem cells. P NATL ACAD SCI USA, 107(31), 13736-13741.
Barbaric I, Gokhale PJ & Andrews PW (2010) High-content screening of small compounds on human embryonic stem cells.. Biochem Soc Trans, 38(4), 1046-1050.
Na J, Furue MK & Andrews PW (2010) Inhibition of ERK1/2 prevents neural and mesendodermal differentiation and promotes human embryonic stem cell self-renewal.. Stem Cell Res, 5(2), 157-169.
Tonge PD & Andrews PW (2010) Retinoic acid directs neuronal differentiation of human pluripotent stem cell lines in a non-cell-autonomous manner.. Differentiation, 80(1), 20-30.
Pewsey E, Bruce C, Tonge P, Evans C, Ow SY, Georgiou AS, Wright PC, Andrews PW & Fazeli A (2010) Nuclear proteome dynamics in differentiating embryonic carcinoma (NTERA-2) cells.. J Proteome Res, 9(7), 3412-3426.
Barbaric I, Gokhale PJ, Jones M, Glen A, Baker D & Andrews PW (2010) Novel regulators of stem cell fates identified by a multivariate phenotype screen of small compounds on human embryonic stem cell colonies.. Stem Cell Res, 5(2), 104-119. View this article in WRRO
Hovatta O, Jaconi M, Tohonen V, Bena F, Gimelli S, Bosman A, Holm F, Wyder S, Zdobnov EM, Irion O , Andrews PW et al (2010) A Teratocarcinoma-Like Human Embryonic Stem Cell (hESC) Line and Four hESC Lines Reveal Potentially Oncogenic Genomic Changes. PLOS ONE, 5(4). View this article in WRRO
Aflatoonian B, Ruban L, Shamsuddin S, Baker D, Andrews P & Moore H (2010) Generation of Sheffield (Shef) human embryonic stem cell lines using a microdrop culture system. In Vitro Cellular & Developmental Biology - Animal, 46(3-4), 236-241.
Närvä E, Autio R, Rahkonen N, Kong L, Harrison N, Kitsberg D, Borghese L, Itskovitz-Eldor J, Rasool O, Dvorak P , Hovatta O et al (2010) High-resolution DNA analysis of human embryonic stem cell lines reveals culture-induced copy number changes and loss of heterozygosity.. Nat Biotechnol, 28(4), 371-377.
International Stem Cell Initiative Consortium , Akopian V, Andrews PW, Beil S, Benvenisty N, Brehm J, Christie M, Ford A, Fox V, Gokhale PJ , Healy L et al (2010) Comparison of defined culture systems for feeder cell free propagation of human embryonic stem cells.. In Vitro Cell Dev Biol Anim, 46(3-4), 247-258. View this article in WRRO
Andrews PW, Benvenisty N, Knowles BB, McKay RDG, Oh SKW, Pera MF, Rossant J & Stacey GN (2010) Human ES cell lines--introduction.. In Vitro Cell Dev Biol Anim, 46(3-4), 167-168.
Avery S, Zafarana G, Gokhale PJ & Andrews PW (2010) The role of SMAD4 in human embryonic stem cell self-renewal and stem cell fate.. Stem Cells, 28(5), 863-873.
Plews JR, Li J, Jones M, Moore HD, Mason C, Andrews PW & Na J (2010) Activation of pluripotency genes in human fibroblast cells by a novel mRNA based approach.. PLoS One, 5(12), e14397. View this article in WRRO
Olariu V, Harrison NJ, Coca D, Gokhale PJ, Baker D, Billings S, Kadirkamanathan V & Andrews PW (2010) Modeling the evolution of culture-adapted human embryonic stem cells.. Stem Cell Res, 4(1), 50-56.
Avery S, Zafarana G, Gokhale PJ & Andrews PW (2010) The role of SMAD4 in human embryonic stem cell self-renewal and stem cell fate. Stem Cells, 28(6), 863-873.
Tonge PD, Olariu V, Coca D, Kadirkamanathan V, Burrell KE, Billings SA & Andrews PW (2010) Prepatterning in the stem cell compartment.. PLoS One, 5(5), e10901. View this article in WRRO
Draper JS & Andrews PW (2009) Surface Antigen Markers, 423-428.
Johnson P & Andrews PW (2009) Cell Fusion and the Differentiated State, 105-110.
Andrews PW, Arias-Diaz J, Auerbach J, Alvarez M, Ahrlund-Richter L, Baker D, Benvenisty N, Ben-Josef D, Blin G, Borghese L , Borstlap J et al (2009) Consensus Guidance for Banking and Supply of Human Embryonic Stem Cell Lines for Research Purposes. STEM CELL REV REP, 5(4), 301-314.
Olariu V, Coca D, Billings SA, Tonge P, Gokhale P, Andrews PW & Kadirkamanathan V (2009) Modified variational Bayes EM estimation of hidden Markov tree model of cell lineages.. Bioinformatics, 25(21), 2824-2830.
Andrews PW (2009) An International Perspective on the National Institute of Health Guidelines for Funding Human Embryonic Stem Cell Research in the United States. STEM CELLS DEV, 18(8), 1113-1114.
Sonne SB, Almstrup K, Dalgaard M, Juncker AS, Edsgard D, Ruban L, Harrison NJ, Schwager C, Abdollahi A, Huber PE , Brunak S et al (2009) Analysis of Gene Expression Profiles of Microdissected Cell Populations Indicates that Testicular Carcinoma In situ Is an Arrested Gonocyte. CANCER RES, 69(12), 5241-5250.
Enver T, Pera M, Peterson C & Andrews PW (2009) Stem Cell States, Fates, and the Rules of Attraction. CELL STEM CELL, 4(5), 387-397.
Harrison NJ, Barnes J, Jones M, Baker D, Gokhale PJ & Andrews PW (2009) CD30 expression reveals that culture adaptation of human embryonic stem cells can occur through differing routes.. Stem Cells, 27(5), 1057-1065. View this article in WRRO
Chen W, Johnson SL, Marcotti W, Andrews PW, Moore HD & Rivolta MN (2009) Human fetal auditory stem cells can be expanded in vitro and differentiate into functional auditory neurons and hair cell-like cells.. Stem Cells, 27(5), 1196-1204.
Wright AJ & Andrews PW (2009) Surface marker antigens in the characterization of human embryonic stem cells.. Stem Cell Res, 3(1), 3-11.
Zafarana G, Avery SR, Avery K, Moore HD & Andrews PW (2009) Specific knockdown of OCT4 in human embryonic stem cells by inducible short hairpin RNA interference.. Stem Cells, 27(4), 776-782. View this article in WRRO
Gokhale PJ & Andrews PW (2009) Human embryonic stem cells: 10 years on.. Lab Invest, 89(3), 259-262.
Andrews PW & Gokhale PJ (2008) How Do Cells Change Their Phenotype, 136-147.
Atlasi Y, Mowla SJ, Ziaee SAM, Gokhale PJ & Andrews PW (2008) OCT4 spliced variants are differentially expressed in human pluripotent and nonpluripotent cells.. Stem Cells, 26(12), 3068-3074.
Calvanese V, Horrillo A, Hmadcha A, Suarez-Alvarez B, Fernandez AF, Lara E, Casado S, Menendez P, Bueno C, Garcia-Castro J , Rubio R et al (2008) Cancer Genes Hypermethylated in Human Embryonic Stem Cells. PLOS ONE, 3(9). View this article in WRRO
Furue MK, Na J, Jackson JP, Okamoto T, Jones M, Baker D, Hatal RI, Moore HD, Sato JD & Andrews PW (2008) Heparin promotes the growth of human embryonic stem cells in a defined serum-free medium. P NATL ACAD SCI USA, 105(36), 13409-13414.
Liew C-G, Draper JS, Walsh J, Moore H & Andrews PW (2008) Transient and Stable Transgene Expression in Human Embryonic Stem Cells. Stem Cells, 26(4), 1094-1094.
Fox V, Gokhale PJ, Walsh JR, Matin M, Jones M & Andrews PW (2008) Cell-cell signaling through NOTCH regulates human embryonic stem cell proliferation.. Stem Cells, 26(3), 715-723.
Gokhale PJ & Andrews PW (2008) New insights into the control of stem cell pluripotency.. Cell Stem Cell, 2(1), 4-5.
Vugler A, Carr A-J, Lawrence J, Chen LL, Burrell K, Wright A, Lundh P, Semo M, Ahmado A, Gias C , da Cruz L et al (2008) Elucidating the phenomenon of HESC-derived RPE: Anatomy of cell genesis, expansion and retinal transplantation. Experimental Neurology, 214(2), 347-361.
Liew CG & Andrews PW (2008) Stem cell therapy to treat diabetes mellitus. Review of Diabetic Studies, 5(4), 203-219.
Liew CG, Shah NN, Briston SJ, Shepherd RM, Khoo CP, Dunne MJ, Moore HD, Cosgrove KE & Andrews PW (2008) PAX4 enhances beta-cell differentiation of human embryonic stem cells.. PLoS One, 3(3), e1783. View this article in WRRO
Vugler A, Lawrence J, Walsh J, Carr A, Gias C, Semo M, Ahmado A, da Cruz L, Andrews P & Coffey P (2007) Embryonic stem cells and retinal repair. Mechanisms of Development, 124(11-12), 807-829.
Damjanov I & Andrews PW (2007) The terminology of teratocarcinomas and teratomas. NAT BIOTECHNOL, 25(11), 1212-1212.
Harrison NJ, Baker D & Andrews PW (2007) Culture adaptation of embryonic stem cells echoes germ cell malignancy.. Int J Androl, 30(4), 275-281.
International Stem Cell Initiative , Adewumi O, Aflatoonian B, Ahrlund-Richter L, Amit M, Andrews PW, Beighton G, Bello PA, Benvenisty N, Berry LS , Bevan S et al (2007) Characterization of human embryonic stem cell lines by the International Stem Cell Initiative.. Nat Biotechnol, 25(7), 803-816.
Draper JS, Séguin CA & Andrews PW (2007) Phenotypic Analysis of Human Embryonic Stem Cells, 91-106.
Liew C-G, Draper JS, Walsh J, Moore H & Andrews PW (2007) Transient and stable transgene expression in human embryonic stem cells.. Stem Cells, 25(6), 1521-1528.
Allegrucci C, Wu YZ, Thurston A, Denning CN, Priddle H, Mummery CL, Ward-van Oostwaard D, Andrews PW, Stojkovic M, Smith N , Parkin T et al (2007) Restriction landmark genome scanning identifies culture-induced DNA methylation instability in the human embryonic stem cell epigenome. HUM MOL GENET, 16(10), 1253-1268.
Park H, Váradi A, Seok H, Jo J, Gilpin H, Liew CG, Jung S, Andrews PW, Molnár E & Cho K (2007) mGluR5 is involved in dendrite differentiation and excitatory synaptic transmission in NTERA2 human embryonic carcinoma cell-derived neurons.. Neuropharmacology, 52(6), 1403-1414.
Josephson R, Ording CJ, Liu Y, Shin S, Lakshmipathy U, Toumadje A, Love B, Chesnut JD, Andrews PW, Rao MS & Auerbach JM (2007) Qualification of embryonal carcinoma 2102Ep as a reference for human embryonic stem cell research. STEM CELLS, 25(2), 437-446.
Baker DEC, Harrison NJ, Maltby E, Smith K, Moore HD, Shaw PJ, Heath PR, Holden H & Andrews PW (2007) Adaptation to culture of human embryonic stem cells and oncogenesis in vivo.. Nat Biotechnol, 25(2), 207-215.
Jackson JP, Tonge PD & Andrews PW (2007) Techniques for Neural Differentiation of Human EC and ES Cells, 61-91.
Chapman H, Piggot C, Andrews PW & Wann KT (2007) Characterisation of large-conductance calcium-activated potassium channels (BKCa) in human NT2-N cells. BRAIN RES, 1129(1), 15-25.
Gokhale PJ & Andrews PW (2006) A prospective on stem cell research.. Semin Reprod Med, 24(5), 289-297.
Harun R, Ruban L, Matin M, Draper J, Jenkins NM, Liew GC, Andrews PW, Li TC, Laird SM & Moore HDM (2006) Cytotrophoblast stem cell lines derived from human embryonic stem cells and their capacity to mimic invasive implantation events.. Hum Reprod, 21(6), 1349-1358. View this article in WRRO
Andrews PW (2006) The selfish stem cell. NAT BIOTECHNOL, 24(3), 325-326.
Adamah DJB, Gokhale PJ, Eastwood DJ, Rajpert De-Meyts E, Goepel J, Walsh JR, Moore HD & Andrews PW (2006) Dysfunction of the mitotic:meiotic switch as a potential cause of neoplastic conversion of primordial germ cells.. Int J Androl, 29(1), 219-227.
Andrews PW (2006) TERA2 and its NTERA2 subline: Pluripotent human embryonal carcinoma cells, 1, 183-190.
Skotheim RI, Autio R, Lind GE, Kraggerud SM, Andrews PW, Monni O, Kallioniemi O & Lothe RA (2006) Novel genomic aberrations in testicular germ cell tumors by array-CGH, and associated gene expression changes. CELL ONCOL, 28(5-6), 315-326. View this article in WRRO
Andrews PW (2005) BOOK REVIEW. Journal of Anatomy, 207(6), 823-824.
Andrews PW, Matin MM, Bahrami AR, Damjanov I, Gokhale P & Draper JS (2005) Embryonic stem (ES) cells and embryonal carcinoma (EC) cells: opposite sides of the same coin.. Biochem Soc Trans, 33(Pt 6), 1526-1530.
Liew C, Moore H, Ruban L, Shah N, Cosgrove K, Dunne M & Andrews P (2005) Human embryonic stem cells: Possibilities for human cell transplantation. Annals of Medicine, 37(7), 521-532.
Enver T, Soneji S, Joshi C, Brown J, Iborra F, Orntoft T, Thykjaer T, Maltby E, Smith K, Abu Dawud R , Jones M et al (2005) Cellular differentiation hierarchies in normal and culture-adapted human embryonic stem cells. HUM MOL GENET, 14(21), 3129-3140.
Andrews PW, Matin MM, Bahrami AR, Damjanov I, Gokhale P & Draper JS (2005) Embryonic stem (ES) cells and embryonal carcinoma (EC) cells: opposite sides of the same coin. Biochemical Society Transactions, 33(6), 1526-1530.
Andrews PW & Benvenisty N (2005) Starting from building blocks: tissue engineering using stem cells. CURR OPIN BIOTECH, 16(5), 485-486.
Bahrami AR, Matin MM & Andrews PW (2005) The CDK inhibitor p27 enhances neural differentiation in pluripotent NTERA2 human EC cells, but does not permit differentiation of 2102Ep nullipotent human EC cells.. Mech Dev, 122(9), 1034-1042.
Skotheim RI, Lind GE, Monni O, Nesland JM, Abeler VM, Fossa SD, Duale N, Brunborg G, Kallioniemi I, Andrews PW & Lothe RA (2005) Differentiation of human embryonal carcinomas in vitro and in vivo reveals expression profiles relevant to normal development. CANCER RES, 65(13), 5588-5598.
Andrews PW, Benvenisty N, McKay R, Pera MF, Rossant J, Semb H, Stacey GN & Steering Committee of the International Stem Cell Initiative (2005) The International Stem Cell Initiative: toward benchmarks for human embryonic stem cell research.. Nat Biotechnol, 23(7), 795-797.
Draper JS, Moore HD, Ruban LN, Gokhale PJ & Andrews PW (2004) Culture and characterization of human embryonic stem cells.. Stem Cells Dev, 13(4), 325-336.
Andrews PW (2004) Response: Karyotype of human ES cells during extended culture. Nature Biotechnology, 22(4), 382-382.
Daheron L, Opitz SL, Zaehres H, Lensch WM, Andrews PW, Itskovitz-Eldor J & Daley GQ (2004) LIF/STAT3 signaling fails to maintain self-renewal of human embryonic stem cells. STEM CELLS, 22(5), 770-778.
Matin MM, Walsh JR, Gokhale PJ, Draper JS, Bahrami AR, Morton I, Moore HD & Andrews PW (2004) Specific knockdown of Oct4 and beta2-microglobulin expression by RNA interference in human embryonic stem cells and embryonic carcinoma cells.. Stem Cells, 22(5), 659-668.
Draper JS, Smith K, Gokhale P, Moore HD, Maltby E, Johnson J, Meisner L, Zwaka TP, Thomson JA & Andrews PW (2004) Recurrent gain of chromosomes 17q and 12 in cultured human embryonic stem cells.. Nat Biotechnol, 22(1), 53-54.
Sperger JM, Chen X, Draper JS, Antosiewicz JE, Chon CH, Jones SB, Brooks JD, Andrews PW, Brown PO & Thomson JA (2003) Gene expression patterns in human embryonic stem cells and human pluripotent germ cell tumors. P NATL ACAD SCI USA, 100(23), 13350-13355.
Flasza M, Shering AF, Smith K, Andrews PW, Talley P & Johnson PA (2003) Reprogramming in inter-species embryonal carcinoma-somatic cell hybrids induces expression of pluripotency and differentiation markers. CLONING STEM CELLS, 5(4), 339-354.
Walsh J & Andrews PW (2003) Expression of Wnt and Notch pathway genes in a pluripotent human embryonal carcinoma cell line and embryonic stem cell.. APMIS, 111(1), 197-210.
Draper JS & Andrews PW (2002) Embryonic stem cells: advances toward potential therapeutic use.. Curr Opin Obstet Gynecol, 14(3), 309-315.
Matin MM, Andrews PW & Hornby DP (2002) Multidimensional differential display via ion-pair reversed-phase denaturing high-performance liquid chromatography.. Anal Biochem, 304(1), 47-54.
Andrews PW (2002) From teratocarcinomas to embryonic stem cells.. Philos Trans R Soc Lond B Biol Sci, 357(1420), 405-417.
Andrews PW, Moore H & Smith A (2002) Human embryonic stem cells: prospects for human health - a 1-day international symposium held at the University of Sheffield. J ANAT, 200(3), 221-223.
Draper JS, Pigott C, Thomson JA & Andrews PW (2002) Surface antigens of human embryonic stem cells: changes upon differentiation in culture.. J Anat, 200(Pt 3), 249-258.
Gribaldo L, Alison M, Andrews PW, Bremer S, Donovan PJ, Knaän-Shanzer S, Mertelsmann R, Spielmann H, Testa NG, Triffitt JT , Zipori D et al (2002) Meeting summary: European Workshop on Stem Cells, European Centre for the Validation of Biomedical Testing Methods, Institute for Health and Consumer Protection, Joint Research Centre, Ispra, Italy, November 21-23, 2001. Experimental Hematology, 30(7), 628-633.
Henderson JK, Draper JS, Baillie HS, Fishel S, Thomson JA, Moore H & Andrews PW (2002) Preimplantation human embryos and embryonic stem cells show comparable expression of stage-specific embryonic antigens.. Stem Cells, 20(4), 329-337.
Duran C, Talley PJ, Walsh J, Pigott C, Morton IE & Andrews PW (2001) Hybrids of pluripotent and nullipotent human embryonal carcinoma cells: partial retention of a pluripotent phenotype.. Int J Cancer, 93(3), 324-332.
Przyborski SA, Morton IE, Wood A & Andrews PW (2000) Developmental regulation of neurogenesis in the pluripotent human embryonal carcinoma cell line NTERA-2.. Eur J Neurosci, 12(10), 3521-3528.
Gokhale PJ, Giesberts AM & Andrews PW (2000) Brachyury is expressed by human teratocarcinoma cells in the absence of mesodermal differentiation.. Cell Growth Differ, 11(3), 157-162.
Badcock G, Pigott C, Goepel J & Andrews PW (1999) The human embryonal carcinoma marker antigen TRA-1-60 is a sialylated keratan sulfate proteoglycan.. Cancer Res, 59(18), 4715-4719.
Giesberts AN, Duran C, Morton IN, Pigott C, White SJ & Andrews PW (1999) The expression and function of cadherin-mediated cell-to-cell adhesion in human embryonal carcinoma cells.. Mech Dev, 83(1-2), 115-125.
Wakeman JA, Walsh J & Andrews PW (1998) Human Wnt-13 is developmentally regulated during the differentiation of NTERA-2 pluripotent human embryonal carcinoma cells.. Oncogene, 17(2), 179-186.
Andrews PW (1998) Teratocarcinomas and human embryology: pluripotent human EC cell lines. Review article.. APMIS, 106(1), 158-167.
Wakeman JA, Heath PR, Pearson RC & Andrews PW (1997) MAL mRNA is induced during the differentiation of human embryonal carcinoma cells into neurons and is also localised within specific regions of the human brain.. Differentiation, 62(2), 97-105.
Andrews PW, Casper J, Damjanov I, Duggan-Keen M, Giwercman A, Hata J, von Keitz A, Looijenga LH, Millán JL, Oosterhuis JW , Pera M et al (1996) Comparative analysis of cell surface antigens expressed by cell lines derived from human germ cell tumours.. Int J Cancer, 66(6), 806-816.
Squires PE, Wakeman JA, Chapman H, Kumpf S, Fidock MD, Andrews PW & Dunne MJ (1996) Regulation of intracellular Ca2+ in response to muscarinic and glutamate receptor agonists during the differentiation of NTERA2 human embryonal carcinoma cells into neurons.. Eur J Neurosci, 8(4), 783-793.
Damjanov I, Zhu ZM, Andrews PW & Fenderson BA (1994) Embryonal carcinoma cells differentiate into parietal endoderm via an intermediate stage corresponding to primitive endoderm. In Vivo, 8(6), 967-973.
ACKERMAN SL, KNOWLES BB & ANDREWS PW (1994) GENE-REGULATION DURING NEURONAL AND NONNEURONAL DIFFERENTIATION OF NTERA2 HUMAN TERATOCARCINOMA-DERIVED STEM-CELLS. MOL BRAIN RES, 25(1-2), 157-162.
WENK J, ANDREWS PW, CASPER J, HATA JI, PERA MF, VONKEITZ A, DAMJANOV I & FENDERSON BA (1994) GLYCOLIPIDS OF GERM-CELL TUMORS - EXTENDED GLOBE-SERIES GLYCOLIPIDS ARE A HALLMARK OF HUMAN EMBRYONAL CARCINOMA-CELLS. INT J CANCER, 58(1), 108-115.
SQUIRES PE, CHAPMAN HM & ANDREWS PW (1994) DEVELOPMENTAL REGULATION OF INTRACELLULAR CA2+ SIGNALS DURING THE NEURONAL DIFFERENTIATION OF NTERA2 HUMAN EMBRYONAL CARCINOMA-CELLS. J PHYSIOL-LONDON, 477P, P87-P87.
Rideg K, Hirka G, Prakash K, Bushar LM, Nothias J-Y, Weinmann R, Andrews PW & Gonczol E (1994) DNA-binding proteins that interact with the 19-base pair (CRE-like) element from the HCMV major immediate early promoter in differentiating human embryonal carcinoma cells. Differentiation, 56(1-2), 119-129.
Andrews PW, Damjanov I, Berends J, Kumpf S, Zappavigna V, Mavilio F & Sampath K (1994) Inhibition of proliferation and induction of differentiation of pluripotent human embryonal carcinoma cells by osteogenic protein-1 (or bone morphogenetic protein-7). Laboratory Investigation, 71(2), 243-251.
GIWERCMAN A, ANDREWS PW, JORGENSEN N, MULLER J, GROEM N & SKAKKEBOEK NE (1993) IMMUNOHISTOCHEMICAL EXPRESSION OF EMBRYONAL MARKER TRA-1-60 IN CARCINOMA IN-SITU AND GERM-CELL TUMORS OF THE TESTIS. CANCER, 72(4), 1308-1314.
Fenderson BA, Radin N & Andrews PW (1993) Differentiation antigens of human germ cell tumours: Distribution of carbohydrate epitopes on glycolipids and glycoproteins analyzed using PDMP, an inhibitor of glycolipid synthesis. European Urology, 23(1), 30-37.
Zeichner SL, Hirka G, Andrews PW & Alwine JC (1992) Differentiation-dependent human immunodeficiency virus long terminal repeat regulatory elements active in human teratocarcinoma cells.. Journal of Virology, 66(4), 2268-2273.
Fenderson BA & Andrews PW (1992) Carbohydrate antigens of embryonal carcinoma cells: Changes upon differentiation. APMIS, 100(27 S), 109-118.
Bottero L, Simeone A, Arcioni L, Acampora D, Andrews PW, Boncinelli E & Mavilio F (1991) Differential Activation of Homeobox Genes by Retinoic Acid in Human Embryonal Carcinoma Cells, 133-143.
Andrews PW, Marrink J, Hirka G, von Keitz A, Sleijfer DT & Gönczöl E (1991) The Surface Antigen Phenotype of Human Embryonal Carcinoma Cells: Modulation Upon Differentiation and Viral Infection, 63-83.
Marrink J, Andrews PW, Van Brummen PJ, De Jong HJ, Sleijfer DTH, Schraffordt Koops H & Oosterhuis JW (1991) Tra-1-60: A new serum marker in patients with germ-cell tumors. International Journal of Cancer, 49(3), 368-372.
Hirka G, Prakash K, Kawashima H, Plotkin SA, Andrews PW & Gönczöl E (1991) Differentiation of human embryonal carcinoma cells induces human immunodeficiency virus permissiveness which is stimulated by human cytomegalovirus coinfection.. Journal of Virology, 65(5), 2732-2735.
Andrews PW & Oliver RTD (1990) Introduction: Germ cell tumours of the testis. Cancer Surveys, 9(2), 239-241.
Simeone A, Acampora D, Arcioni L, Andrews PW, Boncinelli E & Mavilio F (1990) Sequential activation of HOX2 homeobox genes by retinoic acid in human embryonal carcinoma cells. Nature, 346(6286), 763-766.
Andrews PW, Nudelman E, Hakomori S-I & Fenderson BA (1990) Different patterns of glycolipid antigens are expressed following differentiation of TERA-2 human embryonal carcinoma cells induced by retinoic acid, hexamethylene bisacetamide (HMBA) or bromodeoxyuridine (BUdR). Differentiation, 43(2), 131-138.
Chen C, Fenderson BA, Andrews PW & Hakomori S (1989) Glycolipid glycosyltransferases in human embryonal carcinoma cells during retinoic acid induced differentiation. Biochemistry, 28(5), 2229-2238.
Andrews PW, Gönczöl E, Fenderson BA, Holmes EH, O'Malley G, Hakomori S & Plotkin S (1989) Human cytomegalovirus induces stage-specific embryonic antigen 1 in differentiating human teratocarcinoma cells and fibroblasts.. The Journal of Experimental Medicine, 169(4), 1347-1359. View this article in WRRO
Rendt J, Erulkar S & Andrews PW (1989) Presumptive neurons derived by differentiation of a human embryonal carcinoma cell line exhibit tetrodotoxin-sensitive sodium currents and the capacity for regenerative responses. Experimental Cell Research, 180(2), 580-584.
Andrews PW (1988) Human teratocarcinomas. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 948(1), 17-36.
Williams BP, Daniels GL, Pym B, Sheer D, Povey S, Okubo Y, Andrews PW & Goodfellow PN (1988) Biochemical and genetic analysis of the Oka blood group antigen. Immunogenetics, 27(5), 322-329.
Mavilio F, Simeone A, Boncinelli E & Andrews PW (1988) Activation of four homeobox gene clusters in human embryonal carcinoma cells induced to differentiate by retinoic acid. Differentiation, 37(1), 73-79.
Andrews PW (1987) Human teratocarcinoma stem cells: Glycolipid antigen expression and modulation during differentiation. Journal of Cellular Biochemistry, 35(4), 321-332.
Andrews PW & Perussia B (1987) Induction of class i major histocompatibility complex antigens in human teratocarcinoma cells by interferon without induction of differentiation, growth inhibition, or resistance to viral infection. Cancer Research, 47(3), 740-746.
Fenderson BA, Andrews PW, Nudelman E, Clausen H & Hakomori S-I (1987) Glycolipid core structure switching from globo- to lacto- and ganglio-series during retinoic acid-induced differentiation of TERA-2-derived human embryonal carcinoma cells. Developmental Biology, 122(1), 21-34.
ANDREWS PW, FENDERSON B & HAKOMORI S-I (1987) Human embryonal carcinoma cells and their differentiation in culture. International Journal of Andrology, 10(1), 95-104.
SWALLOW DM, POVEY S, PARKAR M, ANDREWS PW, HARRIS H, PYM B & GOODFELLOW P (1986) Mapping of the gene coding for the human liver/bone/kidney isozyme of alkaline phosphatase to chromosome 1. Annals of Human Genetics, 50(3), 229-235.
Tippett P, Andrews PW, Knowles BB, Solter D & Goodfellow PN (1986) Red Cell Antigens P (Globoside) and Luke: Identification by Monoclonal Antibodies Defining the Murine Stage-Specific Embryonic Antigens -3 and -4 (SSEA-3 and SSEA-4). Vox Sanguinis, 51(1), 53-56.
Andrews PW, Gönczöl E, Plotkin SA, Dignazio M & Oosterhuis JW (1986) Differentiation of TERA-2 human embryonal carcinoma cells into neurons and HCMV permissive cells. Differentiation, 31(2), 119-126.
Lee VM & Andrews PW (1986) Differentiation of NTERA-2 clonal human embryonal carcinoma cells into neurons involves the induction of all three neurofilament proteins. The Journal of Neuroscience, 6(2), 514-521.
Andrews PW, Damjanov I, Simon D & Dignazio M (1985) A pluripotent human stem-cell clone isolated from the TERA-2 teratocarcinoma line lacks antigens SSEA-3 and SSEA-4 in vitro, but expresses these antigens when grown as a xenograft tumor. Differentiation, 29(2), 127-135.
DAMJANOV I, CLARK RK & ANDREWS PW (1985) Expression of Keratin Polypeptides in Human Embryonal Carcinoma Cells. Annals of the New York Academy of Sciences, 455(1 Intermediate), 732-733.
ANDREWS PW, KNOWLES BB, PARKAR M, PYM B, STANLEY K & GOODFELLOW PN (1985) A human cell-surface antigen defined by a monoclonal antibody and controlled by a gene on human chromosome 1. Annals of Human Genetics, 49(1), 31-39.
Gonczol E, Andrews PW & Plotkin SA (1985) Cytomegalovirus Infection of Human Teratocarcinoma Cells in Culture. Journal of General Virology, 66(3), 509-515.
Carlin CR & Andrews PW (1985) Human embryonal carcinoma cells express low levels of functional receptor for epidermal growth factor. Experimental Cell Research, 159(1), 17-26.
Gonczol E, Andrews P & Plotkin S (1984) Cytomegalovirus replicates in differentiated but not in undifferentiated human embryonal carcinoma cells. Science, 224(4645), 159-161.
ANDREWS PW, BANTING G, DAMJANOV I, ARNAUD D & AVNER P (1984) Three Monoclonal Antibodies Defining Distinct Differentiation Antigens Associated with Different High Molecular Weight Polypeptides on the Surface of Human Embryonal Carcinoma Cells. Hybridoma, 3(4), 347-361.
Andrews PW, Damjanov I, Simon D, Banting GS, Carlin C, Dracopoli NC & Føgh J (1984) Pluripotent embryonal carcinoma clones derived from the human teratocarcinoma cell line Tera-2. Differentiation in vivo and in vitro. Laboratory Investigation, 50(2), 147-162.
Blaineau C, Connan F, Arnaud D, Andrews P, Williams L, McIlhinney J & Avner P (1984) Definition of three species-specific monoclonal antibodies recognizing antigenic structures present on human embryonal carcinoma cells which undergo modulation duringin vitro differentiation. International Journal of Cancer, 34(4), 487-494.
Andrews PW (1984) Retinoic acid induces neuronal differentiation of a cloned human embryonal carcinoma cell line in vitro. Developmental Biology, 103(2), 285-293.
ANDREWS PW, MEYER LJ, BEDNARZ KL & HARRIS H (1984) Two Monoclonal Antibodies Recognizing Determinants on Human Embryonal Carcinoma Cells React Specifically with the Liver Isozyme of Human Alkaline Phosphatase. Hybridoma, 3(1), 33-39.
Oosterhuis JW, Andrews PW, Knowles BB & Damjanov I (1984) Effects ofCIS-platinum on embryonal carcinoma cell linesin vitro. International Journal of Cancer, 34(1), 133-139.
Damjanov I, Clark RK & Andrews PW (1984) Cytoskeleton of human embryonal carcinoma cells. Cell Differentiation, 15(2-4), 133-139.
Goodfellow PN & Andrews PW (1983) Human genetics: Is there a human T/t locus?. Nature, 302(5910), 657-658.
Kannagi R, Cochran NA, Ishigami F, Hakomori S, Andrews PW, Knowles BB & Solter D (1983) Stage-specific embryonic antigens (SSEA-3 and -4) are epitopes of a unique globo-series ganglioside isolated from human teratocarcinoma cells.. The EMBO Journal, 2(12), 2355-2361.
Tunnacliffe A, Goodfellow P, Banting G, Solomon E, Knowles BB & Andrews P (1983) Human chromosome 11 carries at least four genes controlling expression of cell-surface antigens. Somatic Cell Genetics, 9(5), 629-642.
Cossu G, Andrews PW & Warren L (1983) Covalent binding of lactosaminoglycans and heparan sulphate to fibronectin synthesized by a human teratocarcinoma cell line. Biochemical and Biophysical Research Communications, 111(3), 952-957.
Damjanov I (1983) Ultrastructural differentiation of a clonal human embryonal carcinoma cell line in vitro. Cancer Research, 43(5), 2190-2198.
Matthaei KI, Andrews PW & Bronson DL (1983) Retinoic acid fails to induce differentiation in human teratocarcinoma cell lines that express high levels of a cellular receptor protein. Experimental Cell Research, 143(2), 471-474.
Andrews PW & Goodfellow PN (1982) Analysing the mouse T/t complex. Nature, 299(5881), 296-297.
Goodfellow PN & Andrews PW (1982) Sexual differentiation and H-Y antigen. Nature, 295(5844), 11-13.
Andrews PW (1982) Human embryonal carcinoma cells in culture do not synthesize fibronectin until they differentiate. International Journal of Cancer, 30(5), 567-571.
Goodfellow PN & Andrews PW (1982) The biology of teratocarcinomas. Nature, 300(5888), 107-108.
Andrews PW, Goodfellow PN, Shevinsky LH, Bronson DL & Knowles BB (1982) Cell-surface antigens of a clonal human embryonal carcinoma cell line: Morphological and antigenic differentiation in culture. International Journal of Cancer, 29(5), 523-531.
Andrews PW, Knowles BB & Goodfellow PN (1981) A human cell-surface antigen defined by a monoclonal antibody and controlled by a gene on chromosome 12. Somatic Cell Genetics, 7(4), 435-443.
Benham FJ, Andrews PW, Knowles BB, Bronson DL & Harris H (1981) Alkaline phosphatase isozymes as possible markers of differentiation in human testicular teratocarcinoma cell lines. Developmental Biology, 88(2), 279-287.
Andrews PW, Bronson DL, Benham F, Strickland S & Knowles BB (1980) A comparative study of eight cell lines derived from human testicular teratocarcinoma. International Journal of Cancer, 26(3), 269-280.
Bronsor DL, Lange PH, Fraley EE, Cervenka J, Andrews PW & Solter D (1980) Cell line derived from a metastasis of a human testicular germ cell tumor. Cancer Research, 40(7), 2500-2506.
Andrews PW & Goodfellow PN (1980) Antigen expression by somatic cell hybrids of a murine embryonal carcinoma cell with thymocytes and L cells. Somatic Cell Genetics, 6(2), 271-284.
Saldana-Guerrero IM, Montano-Gutierrez LF, Boswell K, Hafemeister C, Poon E, Shaw LE, Stavish D, Lea RA, Wernig-Zorc S, Bozsaky E , Fetahu IS et al () A human neural crest model reveals the developmental impact of neuroblastoma-associated chromosomal aberrations. Nature Communications, 15(1).
Andrews PW () The origins of human pluripotent stem cells: the road from a cancer to regenerative medicine. In Vitro Cellular & Developmental Biology - Animal.
() In Vivo Tumorigenicity of the 20q11.21 Amplicon in an Engraftment Model of hPSCs and Differentiated Liver Cells. Journal of Stem Cells and Regenerative Medicine.
Frith TJR, Granata I, Stout E, Wind M, Thompson O, Neumann K, Stavish D, Heath PR, Hackland JOS, Anastassiadis K , Gouti M et al () Human axial progenitors generate trunk neural crest cells. View this article in WRRO
Barbaric I, Allison T, Powles-Glover N, Biga V & Andrews P () Human pluripotent stem cells as tools for high-throughput and high-content screening in drug discovery. International Journal of High Throughput Screening, 1-1. View this article in WRRO
Andrews PW, Bronson DL, Wiles MV & Goodfellow PN () The expression of MHC antigens by human teratocarcinoma derived cell lines. Tissue Antigens, 17(5), 493-500.

Chapters

Hackland JOS, Frith TJR & Andrews PW (2019) Fully Defined and Xeno-Free Induction of hPSCs into Neural Crest Using Top-Down Inhibition of BMP Signaling, Methods in Molecular Biology (pp. 49-54). Springer New York
Draper JS & Andrews PW (2013) Surface Antigen Markers, Handbook of Stem Cells (pp. 375-382). Elsevier
Johnson P & Andrews PW (2013) Cell Fusion and the Differentiated State, Handbook of Stem Cells (pp. 89-94). Elsevier
Addis RC, Ahlstrom JD, Amit M, Andrews PW, Axelman J, Surani MA, Benvenisty N, Bhatia M, Brivanlou AH, Carnwath JW , Carpenter MK et al (2013) Contributors, Handbook of Stem Cells (pp. xiii-xv). Elsevier
Harrison NJ, Baker D & Andrews PW (2012) The Significance of Culture Adaptation of Embryonic Stem Cells for Regenerative Medicine, Advances in Stem Cell Research (pp. 17-27). Humana Press
Harrison NJ, Baker D & Andrews PW (2011) Culture Adaptation of Pluripotent Stem Cells: Challenges and Opportunities, Nuclear Reprogramming and Stem Cells (pp. 265-276). Humana Press
Andrews PW (2011) Treating Oncologic Disease, Translational Stem Cell Research (pp. 35-43). Humana Press
Harrison NJ, Barbaric I & Andrews PW (2010) Human Embryonic Stem Cell Characterization: Similarities and Differences between Cell Lines and Sources, Stem Cells (pp. 1-22). WORLD SCIENTIFIC
Harrison NJ, Barbaric I & Andrews PW (2010) Human embryonic stem cell characterization: Similarities and differences between cell lines and sources, Stem Cells: From Bench to Bedside, Second Edition (pp. 1-22).
Addis RC, Amit M, Andrews PW, Anversa P, Atala A, Axelman J, Bang AG, Barrandon Y, Bauer SR, Becker D , Benvenisty N et al (2009) Contributors, Essentials of Stem Cell Biology (pp. ix-xiii). Elsevier
Tonge PD & Andrews PW (2007) Human Embryonal Carcinoma (EC) Cells: Complementary Tools for Embryonic Stem Cell Research, Human Cell Culture (pp. 235-253). Springer Netherlands
Andrews PW & Gokhale PJ (2007) How Do Cells Change Their Phenotype, Principles of Regenerative Medicine (pp. 136-147).
ANDREWS P (2006) TERA2 and Its NTERA2 SublinePluripotent Human Embryonal Carcinoma Cells, Cell Biology (pp. 183-190). Elsevier
Matin MM, Bahrami A, Liew D & Andrews PW (2005) Characterization of Human Embryonic Stem Cells, Stem Cells (pp. 38-54). WORLD SCIENTIFIC
Johnson PA & Andrews PW (2004) Cell Fusion and the Differentiated State, Handbook of Stem Cells (pp. 111-118).
Draper JS & Andrews PW (2004) Surface Antigen Markers, Handbook of Stem Cells (pp. 565-571).
Draper JS & Andrews PW (2004) Surface Antigen Markers, Handbook of Stem Cells (pp. 565-571). Elsevier
Johnson PA & Andrews PW (2004) Cell Fusion and the Differentiated State, Handbook of Stem Cells (pp. 111-118). Elsevier

Conference proceedings papers

Frith TJR, McCann C, Gogolou A, Thapar N, Tsakiridis A, Burns A & Andrews PW (2019) Transplantation of hPSC derived enteric neural progenitors as a basis to derive a preclinical cell therapy for Hirschsprung's disease. HUMAN GENE THERAPY, Vol. 30(8) (pp A17-A17)
Halliwell JA, Barbaric I & Andrews PW (2019) Mechanisms that lead to genetic instability in human pluripotent stem cells. HUMAN GENE THERAPY, Vol. 30(8) (pp A18-A19)
Biga V, Alves Coelho OM, Gokhale PJ, Mason JE, Mendes EMAM, Andrews PW & Coca D (2017) Statistical texture-based mapping of cell differentiation under microfluidic flow. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), Vol. 10477 LNBI (pp 93-106) View this article in WRRO
Ahmed MI, Harrison NJ, Mardaryev AN, Fessing MY, Poterlowicz K, Andrews PW & Botchkarev VA (2013) Genome organizer Satb1 regulates differentiation-associated silencing of the Nanog locus by modulating its nuclear positioning in human embryonic stem cells. JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol. 133 (pp S246-S246)
Ahmed MI, Harrison NJ, Poterlowicz K, Mardaryev AN, Fessing MY, Andrews PW & Botchkarev VA (2012) Differentiation-associated Silencing of the Nanog Locus is Accompanied by Changes in its Nuclear Positioning in Human Embryonic Stem Cells. JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol. 132 (pp S105-S105)
Ahmed MI, Harrison NJ, Mardaryev A, Fessing MY, Poterlowicz K, Andrews PW & Botchkarev VA (2012) Differentiation-associated silencing of the Nanog locus is accompanied by changes in its nuclear positioning in human embryonic stem cells. JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol. 132 (pp S141-S141)
Adamah D, Gokhale PJ, Walsh J & Andrews PW (2002) A notch-related gene located on the long arm of human chromosome 12. GERM CELL TUMOURS V (pp 30-31)
Gokhale PJ, Eastwood D, Walsh J & Andrews PW (1998) The possible role of Notch genes in germ cell tumour development and progression. GERM CELL TUMOURS IV (pp 69-71)
Gels ME, Marrink J, Visser P, Sleijfer DT, Droste JHJ, Hoekstra HJ, Andrews PW & Koops HS (1997) Importance of a new tumor marker TRA-1-60 in the follow-up of patients with clinical stage I nonseminomatous testicular germ cell tumors. ANNALS OF SURGICAL ONCOLOGY, Vol. 4(4) (pp 321-327)
ANDREWS PW, MAVILIO F, ZAPPAVIGNA V & SAMPATH TK (1994) GROWTH-INHIBITION AND DIFFERENTIATION OF A HUMAN EMBRYONAL CARCINOMA (EC) CELL-LINE BY OSTEOGENIC PROTEIN-1 (OP-1). GERM CELL TUMOURS III, Vol. 91 (pp 151-152)

Preprints

Jevans B, Cooper F, Fatieieva Y, Gogolou A, Kang Y-N, Restuadi R, Berghe PV, Adameyko I, Thapar N, Andrews PW , Coppi PD et al (2023) Human enteric nervous system progenitor transplantation restores functional responses in Hirschsprung Disease patient-derived tissue, Cold Spring Harbor Laboratory.
Saldana-Guerrero IM, Montano-Gutierrez LF, Hafemeister C, Stavish D, Shaw LE, Fetahu IS, Wenninger-Weinzierl A, Sturtzel C, Souilhol C, Tarelli S , Shoeb MR et al (2022) Neuroblastoma-associated chromosomal aberrations drive cell identity loss in human neural crest via disruption of developmental regulators, Cold Spring Harbor Laboratory.
Halliwell JA, Baker D, Judge K, Quail MA, Oliver K, Betteridge E, Skelton J, Andrews PW & Barbaric I () Template switching mechanism drives the tandem amplification of chromosome 20q11.21 in human pluripotent stem cells, Cold Spring Harbor Laboratory.
Boisen IM, Nielsen JE, Kooij I, Kaludjerovic J, O’Shaughnessy PJ, Andrews PW, Ide N, Toft BG, Juul A, Smith LB , Norman RW et al () Ectopic FGF23 production induces mineral changes, osteogenic transdifferentiation, and cancer associated microcalcifications, Cold Spring Harbor Laboratory.
Wind M, Gogolou A, Manipur I, Granata I, Butler L, Andrews PW, Barbaric I, Ning K, Guarracino MR, Placzek M & Tsakiridis A () Defining the signalling determinants of a posterior ventral spinal cord identity in human neuromesodermal progenitor derivatives, Cold Spring Harbor Laboratory.
Halliwell JA, Frith TJR, Laing O, Price CJ, Bower OJ, Stavish D, Gokhale PJ, Hewitt Z, El-Khamisy SF, Barbaric I & Andrews PW () Nucleosides rescue replication-mediated genome instability of human pluripotent stem cells, Cold Spring Harbor Laboratory.
Frith TJR, Gogolou A, Hackland JOS, Barbaric I, Thapar N, Burns AJ, Andrews PW, Tsakiridis A & McCann CJ () Retinoic acid accelerates the specification of enteric neural progenitors from in vitro-derived neural crest.
Stavish D, Böiers C, Price C, Frith TJR, Halliwell J, Barbaric I, Brown J, Carr J, James C, Andrews PW & Enver T () Generation and Trapping of a Mesoderm Biased State of Human Pluripotency, Cold Spring Harbor Laboratory.

Grants

European Union
UK Regenerative Medicine
MRC/International Stem Cell Forum

Teaching activities

Undergraduate and postgraduate taught modules

Level 3:

BMS382 Stem Cell Biology
BMS349 Extended Library Project

Masters (MSc):

BMS6056 Stem Cell Biology

Professional activities and memberships

Chairman, Department of Biomedical Science, 1995-2003.
Co-founder and Director, Axordia Ltd., A University Spin-out Company (now a subsidiary of Pfizer)
Director, Centre for Stem Cell Biology (CSCB)
Co-ordinator of ESTOOLS, a European FP6 Integrated Project (2006–2010)

Current external activities

Editorial Boards: Journal of. Anatomy, Stem Cells, Regenerative Medicine, Handbook of Stem Cells, Stem Cell Research, Stem Cells and Development.
Co-ordinator of the International Stem Cell Initiative 2003 – present

Past

2014 Director, Pluripotent Stem Cell Platform (a Hub under the UKRMP) 2014 - 2018
2008 Member MRC Translational Stem Cell Research Panel (July 2008 – 2013)
2007 Member SAB for Stem Cells for Safer Medicines (SC4SM), a PPP company established by the DTI and the ABPI to develop applications of human ES cells in predictive toxicology (2007 – 2011).
2010 SAB Bioprocessing Technology Institute, Biopolis, Singapore, 2010 - 2011.
2009 Participant in MRC delegations to California (Jan 2009); to China (May 2009)
2009 Member of INSERM review committee for INSERM Unit, I-Stem, Evry, Paris. Jan 2009
2008 Invited Participant in UK FCO sponsored ‘Road Show on UK Human ES cell research, California, Feb 2008
2007 Review panel for Canadian Stem Cell Network (Sept 2007).
2007 Expert Review Panel for 21st Century Centre of Excellence Program, Kyoto University (Japan, June 2007)
2006 Member Steering Committee for UK Toxicology Initiative July 2006 – 2007
2006 Co-ordinated for MRC and CIRM a UK:California Stem Cell meeting, held in the UK Nov 2006.
2006 Member, NIH National Stem Cell Bank, USA, 2006 - 2009
2006 Elected Board Member, ISSCR, March 2006 to 2009
2005 Member MRC Molecular Cell and Medicine Board April 2005- April 2010
2005 Represented MRC in meeting with California Institute Regenerative Medicine, San Francisco April 2005