Professor Mikko Juusola

All publications

Journal articles

• Bridges AD, Royka A, Wilson T, Lockwood C, Richter J, Juusola M & Chittka L (2024) Bumblebees socially learn behaviour too complex to innovate alone. Nature, 627, 572-578. View this article in WRRO
• Kemppainen J, Scales B, Razban Haghighi K, Takalo J, Mansour N, McManus J, Leko G, Saari P, Hurcomb J, Antohi A , Suuronen J-P et al (2022) Binocular mirror–symmetric microsaccadic sampling enables Drosophila hyperacute 3D vision. Proceedings of the National Academy of Sciences, 119(12). View this article in WRRO
• Kemppainen J, Mansour N, Takalo J & Juusola M (2022) High-speed imaging of light-induced photoreceptor microsaccades in compound eyes. Communications Biology, 5(1). View this article in WRRO
• Song Z, Zhou Y, Feng J & Juusola M (2021) Multiscale 'whole-cell' models to study neural information processing – new insights from fly photoreceptor studies. Journal of Neuroscience Methods.
• Li X, Abou Tayoun A, Song Z, Dau A, Rien D, Jaciuch D, Dongre S, Blanchard F, Nikolaev A, Zheng L , Bollepalli MK et al (2019) Ca2+-activated K+ channels reduce network excitability, improving adaptability and energetics for transmitting and perceiving sensory information. Journal of Neuroscience. View this article in WRRO
• Juusola MI, Dau A, Song Z, Solanki N, Rien D, Jaciuch D, Dongre S, Blanchard F, de Polavieja GG, Hardie RC & Takalo J (2017) Microsaccadic sampling of moving image information provides Drosophila hyperacute vision. eLife, 6. View this article in WRRO
• Song Z & Juusola M (2017) Shining new light into the workings of photoreceptors and visual interneurons.. J Physiol, 595(16), 5425-5426. View this article in WRRO
• Song Z, Zhou Y & Juusola M (2017) Modeling elucidates how refractory period can provide profound nonlinear gain control to graded potential neurons. Physiological Reports, 5. View this article in WRRO
• Song Z & Juusola MI (2017) A biomimetic fly photoreceptor model elucidates how stochastic adaptive quantal sampling provides a large dynamic range. Journal of Physiology. View this article in WRRO
• Juusola MI & Song Z (2017) How a fly photoreceptor samples light information in time. Journal of Physiology. View this article in WRRO
• Song Z, Zhou Y & Juusola MI (2016) Random Photon Absorption Model Elucidates How Early Gain Control in Fly Photoreceptors Arises from Quantal Sampling. Frontiers in Computational Neuroscience, 10. View this article in WRRO
• Friederich U, Billings SA, Hardie RC, Juusola M & Coca D (2016) Fly Photoreceptors Encode Phase Congruency. PLoS ONE, 11(6). View this article in WRRO
• Juusola MI, Dau A, Zheng L & Rien D (2016) Electrophysiological Method for Recording Intracellular Voltage Responses of Drosophila Photoreceptors and Interneurons to Light Stimuli In Vivo. Journal of Visualized Experiments, 112. View this article in WRRO
• Dau A, Friederich U, Dongre S, Li X, Bollepalli MK, Hardie RC & Juusola MI (2016) Evidence for Dynamic Network Regulation of Drosophila Photoreceptor Function from Mutants Lacking the Neurotransmitter Histamine. Frontiers in Neural Circuits, 10. View this article in WRRO
• Juusola M, Hardie RC & Arikawa K (2016) Professor Matti Weckström (1959–2015). Journal of Comparative Physiology A, 202(2), 85-86.
• Song Z, Zhou Y & Juusola M (2015) Predictable implications of random photon absorption for photoreceptors' gain control. BMC Neuroscience, 16(S1).
• Randall AS, Liu C-H, Chu B, Zhang Q, Dongre SA, Juusola M, Franze K, Wakelam MJO & Hardie RC (2015) Speed and Sensitivity of Phototransduction in Drosophila Depend on Degree of Saturation of Membrane Phospholipids. Journal of Neuroscience, 35(6), 2731-2746. View this article in WRRO
• Hardie RC & Juusola M (2015) Phototransduction in Drosophila. Current Opinion in Neurobiology, 34, 37-45. View this article in WRRO
• Song Z & Juusola M (2014) Refractory sampling links efficiency and costs of sensory encoding to stimulus statistics.. J Neurosci, 34(21), 7216-7237. View this article in WRRO
• Li M, Liu F, Juusola M & Tang S (2014) Perceptual color map in macaque visual area V4.. J Neurosci, 34(1), 202-217.
• Heimonen K, Immonen E-V, Frolov RV, Salmela I, Juusola M, Vähäsöyrinki M & Weckström M (2012) Signal coding in cockroach photoreceptors is tuned to dim environments.. J Neurophysiol, 108(10), 2641-2652.
• Song Z, Postma M, Billings SA, Coca D, Hardie RC & Juusola M (2012) Stochastic, adaptive sampling of information by microvilli in fly photoreceptors. Current Biology, 22(15), 1371-1380.
• Wardill TJ, List O, Li X, Dongre S, McCulloch M, Ting C-Y, O'Kane CJ, Tang S, Lee C-H, Hardie RC & Juusola M (2012) Multiple spectral inputs improve motion discrimination in the Drosophila visual system.. Science, 336(6083), 925-931. View this article in WRRO
• Tayoun ANA, Li X, Chu B, Hardie RC, Juusola M & Dolph PJ (2011) The drosophila SK channel (dSK) contributes to photoreceptor performance by mediating sensitivity control at the first visual network. Journal of Neuroscience, 31(39), 13897-13910.
• Winder SJ, Lipscomb L, Angela Parkin C & Juusola M (2011) The proteasomal inhibitor MG132 prevents muscular dystrophy in zebrafish.. PLoS Curr, 3, RRN1286.
• Gonzalez-Bellido PT, Wardill TJ & Juusola MI (2011) Compound eyes and retinal information processing in miniature dipteran species match their specific ecological demands. Proceedings of the National Academy of Sciences of USA, 108, 4224-4229. View this article in WRRO
• Song ZY, Coca D, Billings SA & Juusola M (2010) Modelling molecular mechanisms in Drosophila photoreceptor. J NEUROGENET, 24, 7-8.
• Tang S & Juusola MI (2010) Intrinsic Activity in the Fly Brain Gates Visual Information during Behavioral Choices. PLoS One, 5(12). View this article in WRRO
• Zheng L, Nikolaev A, Wardill TJ, O'Kane CJ, de Polavieja GG & Juusola M (2009) Network adaptation improves temporal representation of naturalistic stimuli in Drosophila eye: I dynamics. PLoS ONE, 4(1). View this article in WRRO
• Nikolaev A, Zheng L, Wardill TJ, de Polavieja GG, Juusola MI & O'Kane CJ (2009) Network adaptation improves temporal representation of naturalistic stimuli in Drosophila eye: II mechanisms.. PLoS One(4). View this article in WRRO
• Wardill T & Juusola M (2009) Dissecting Drosophila visual circuits to understand lobula plate motion processing.. J NEUROGENET, 23, S61-S61.
• Tang SM & Juusola M (2009) Selective attention gates visual information processing in Drosophila. J NEUROGENET, 23, S62-S63.
• Gonzalez-Bellido PT, Wardill TJ, Kostyleva R, Meinertzhagen IA & Juusola MI (2009) Overexpressing Temperature-Sensitive Dynamin Decelerates Phototransduction and Bundles Microtubules in Drosophila Photoreceptors.. Journal of Neuroscience, 29, 14199-14210. View this article in WRRO
• Pantazis A, Segaran A, Liu CH, Nikolaev A, Rister J, Thum AS, Roeder T, Semenov E, Juusola M & Hardie RC (2008) Distinct roles for two histamine receptors (hclA and hclB) at the Drosophila photoreceptor synapse. Journal of Neuroscience, 28(29), 7250-7259.
• Faivre OC & Juusola MI (2008) Visual coding in locust photoreceptors.. PLoS One, 3(5). View this article in WRRO
• Juusola M, Robinson HPC & de Polavieja GG (2007) Coding with spike shapes and graded potentials in cortical networks.. Bioessays, 29(2), 178-187.
• Robinson HPC, de Polavieja GG & Juusola M (2007) Coding by action potential waveform in the cortex. NEUROSCI RES, 58, S28-S28.
• Zheng L, De Polavieja GG & Juusola M (2006) Dynamic optimization of sensory information by adapting histamine receptors at the first visual synapses of Drosophila. J NEUROGENET, 20(3-4), 266-267.
• Nikolaev A, Zheng L, Wardill T, O'Kane C, Whitworth A & Juusola M (2006) Impact of synaptic feedbacks from L2 neurones on the signaling performance of Drosophila photoreceptors. J NEUROGENET, 20(3-4), 191-192.
• McQuibban GA, Lee JR, Zheng L, Juusola M & Freeman M (2006) Normal mitochondrial dynamics requires rhomboid-7 and affects Drosophila lifespan and neuronal function.. Curr Biol, 16(10), 982-989.
• Zheng L, de Polavieja GG, Wolfram V, Asyali MH, Hardie RC & Juusola M (2006) Feedback network controls photoreceptor output at the layer of first visual synapses in Drosophila.. J Gen Physiol, 127(5), 495-510.
• Vähäsöyrinki M, Niven JE, Hardie RC, Weckström M & Juusola M (2006) Robustness of neural coding in Drosophila photoreceptors in the absence of slow delayed rectifier K+ channels.. J Neurosci, 26(10), 2652-2660.
• de Polavieja GG, Harsch A, Kleppe I, Robinson HPC & Juusola M (2005) Stimulus history reliably shapes action potential waveforms of cortical neurons.. J Neurosci, 25(23), 5657-5665.
• Asyali MH & Juusola M (2005) Use of meixner functions in estimation of Volterra kernels of nonlinear systems with delay.. IEEE Trans Biomed Eng, 52(2), 229-237.
• Wolfram V & Juusola M (2004) Impact of rearing conditions and short-term light exposure on signaling performance in Drosophila photoreceptors.. J Neurophysiol, 92(3), 1918-1927.
• Niven JE, Vähäsöyrinki M, Juusola M & French AS (2004) Interactions between light-induced currents, voltage-gated currents, and input signal properties in Drosophila photoreceptors.. J Neurophysiol, 91(6), 2696-2706.
• Juusola M, Niven JE & French AS (2003) Shaker K+ channels contribute early nonlinear amplification to the light response in Drosophila photoreceptors.. J Neurophysiol, 90(3), 2014-2021.
• Niven JE, Vähäsöyrinki M & Juusola M (2003) Shaker K(+)-channels are predicted to reduce the metabolic cost of neural information in Drosophila photoreceptors.. Proc Biol Sci, 270 Suppl 1, S58-S61.
• Juusola M & de Polavieja GG (2003) The rate of information transfer of naturalistic stimulation by graded potentials.. J Gen Physiol, 122(2), 191-206.
• Niven JE, Vähäsöyrinki M, Kauranen M, Hardie RC, Juusola M & Weckström M (2003) The contribution of Shaker K+ channels to the information capacity of Drosophila photoreceptors.. Nature, 421(6923), 630-634.
• Hardie RC, Martin F, Cochrane GW, Juusola M, Georgiev P & Raghu P (2002) Molecular basis of amplification in Drosophila phototransduction: roles for G protein, phospholipase C, and diacylglycerol kinase.. Neuron, 36(4), 689-701.
• Hardie RC, Raghu P, Moore S, Juusola M, Baines RA & Sweeney ST (2001) Calcium influx via TRP channels is required to maintain PIP2 levels in Drosophila photoreceptors.. Neuron, 30(1), 149-159.
• Juusola M & Hardie RC (2001) Light adaptation in Drosophila photoreceptors: I. Response dynamics and signaling efficiency at 25 degrees C.. J Gen Physiol, 117(1), 3-25.
• Juusola M & Hardie RC (2001) Light adaptation in Drosophila photoreceptors: II. Rising temperature increases the bandwidth of reliable signaling.. J Gen Physiol, 117(1), 27-42.
• Marmarelis VZ, Juusola M & French AS (1999) Principal dynamic mode analysis of nonlinear transduction in a spider mechanoreceptor.. Ann Biomed Eng, 27(3), 391-402.
• Juusola M & French AS (1998) Adaptation properties of two types of sensory neurons in a spider mechanoreceptor organ.. J Neurophysiol, 80(5), 2781-2784.
• Korenberg MJ, Juusola M & French AS (1998) Two methods for calculating the responses of photoreceptors to moving objects.. Ann Biomed Eng, 26(2), 308-314.
• Juusola M & French AS (1997) The efficiency of sensory information coding by mechanoreceptor neurons.. Neuron, 18(6), 959-968.
• Juusola M & French AS (1997) Visual acuity for moving objects in first- and second-order neurons of the fly compound eye.. J Neurophysiol, 77(3), 1487-1495.
• Juusola M, Seyfarth EA & French AS (1997) Rapid coating of glass-capillary microelectrodes for single-electrode voltage-clamp.. J Neurosci Methods, 71(2), 199-204.
• JUUSOLA M (1997) . J. Neurophysiol., 77, 1487-1487.
• Juusola M, French AS, Uusitalo RO & Weckström M (1996) Information processing by graded-potential transmission through tonically active synapses.. Trends Neurosci, 19(7), 292-297.
• French AS & Juusola M (1996) Resolution of moving dots by first- and second-order visual neurons in the fly eye. PROG BIOPHYS MOL BIO, 65, PG206-PG206.
• Juusola M & French AS (1995) Transduction and adaptation in spider slit sense organ mechanoreceptors.. J Neurophysiol, 74(6), 2513-2523.
• Juusola M, Weckström M, Uusitalo RO, Korenberg MJ & French AS (1995) Nonlinear models of the first synapse in the light-adapted fly retina.. J Neurophysiol, 74(6), 2538-2547.
• Juusola M & French AS (1995) Recording from cuticular mechanoreceptors during mechanical stimulation.. Pflugers Arch, 431(1), 125-128.
• Uusitalo RO, Juusola M, Kouvalainen E & Weckström M (1995) Tonic transmitter release in a graded potential synapse.. J Neurophysiol, 74(1), 470-473.
• Uusitalo RO, Juusola M & Weckström M (1995) Graded responses and spiking properties of identified first-order visual interneurons of the fly compound eye.. J Neurophysiol, 73(5), 1782-1792.
• Weckström M, Juusola M, Uusitalo RO & French AS (1995) Fast-acting compressive and facilitatory nonlinearities in light-adapted fly photoreceptors.. Ann Biomed Eng, 23(1), 70-77.
• Juusola M, Uusitalo RO & Weckström M (1995) Transfer of graded potentials at the photoreceptor-interneuron synapse.. J Gen Physiol, 105(1), 117-148.
• JUUSOLA M (1995) . J. Neurophysiol., 74, 2513-2523.
• JUUSOLA M (1995) . Pflugers Arch., 431, 125-128.
• Juusola M, Seyfarth EA & French AS (1994) Sodium-dependent receptor current in a new mechanoreceptor preparation.. J Neurophysiol, 72(6), 3026-3028.
• Kouvalainen E, Weckström M & Juusola M (1994) A method for determining photoreceptor signal-to-noise ratio in the time and frequency domains with a pseudorandom stimulus.. Vis Neurosci, 11(6), 1221-1225.
• Juusola M, Kouvalainen E, Järvilehto M & Weckström M (1994) Contrast gain, signal-to-noise ratio, and linearity in light-adapted blowfly photoreceptors.. J Gen Physiol, 104(3), 593-621.
• Juusola M (1994) Measuring complex admittance and receptor current by single electrode voltage-clamp.. J Neurosci Methods, 53(1), 1-6.
• JUUSOLA M (1994) . J. Neurophysiol., 72, 2026-3028.
• French AS, Korenberg MJ, Järvilehto M, Kouvalainen E, Juusola M & Weckström M (1993) The dynamic nonlinear behavior of fly photoreceptors evoked by a wide range of light intensities.. Biophys J, 65(2), 832-839.
• Juusola M & Weckström M (1993) Band-pass filtering by voltage-dependent membrane in an insect photoreceptor.. Neurosci Lett, 154(1-2), 84-88.
• JUUSOLA M (1993) LINEAR AND NONLINEAR CONTRAST CODING IN LIGHT-ADAPTED BLOWFLY PHOTORECEPTORS. J COMP PHYSIOL A, 172(4), 511-521.
• UUSITALO RO, JUUSOLA M & WECKSTROM M (1993) A NA+-DEPENDENT HCO3-/CL--EXCHANGE MECHANISM IS RESPONSIBLE FOR THE MAINTENANCE OF THE E(CL) IN 1ST-ORDER VISUAL INTERNEURONS OF THE FLY COMPOUND EYE. INVEST OPHTH VIS SCI, 34(4), 1156-1156.
• WECKSTROM M, JUUSOLA M & LAUGHLIN SB (1992) PRESYNAPTIC ENHANCEMENT OF SIGNAL TRANSIENTS IN PHOTORECEPTOR TERMINALS IN THE COMPOUND EYE. P ROY SOC LOND B BIO, 250(1327), 83-89.
• Weckström M, Kouvalainen E & Juusola M (1992) Measurement of cell impedance in frequency domain using discontinuous current clamp and white-noise-modulated current injection.. Pflugers Arch, 421(5), 469-472.
• UUSITALO R, WECKSTROM M & JUUSOLA M (1992) A SODIUM CONDUCTANCE IS RESPONSIBLE FOR THE LIGHT-OFF SPIKE GENERATION IN THE NONSPIKING VISUAL INTERNEURONS OF THE FLY 1ST OPTIC NEUROPIL. INVEST OPHTH VIS SCI, 33(4), 1409-1409.
• Juusola M, Dau A, Zheng L & Rien D () Electrophysiological Method for Recording Intracellular Voltage Responses of <em>Drosophila</em> Photoreceptors and Interneurons to Light Stimuli <em>In Vivo</em>. Journal of Visualized Experiments(112).
• Tang S & Juusola M () Intrinsic Activity in the Fly Brain Gates Visual Information during Behavioral Choices. Nature Precedings.
• Jaciuch D, Munns J, Chawla S, Davis SJ & Juusola M () Selective human tau protein expression in different clock circuits of the Drosophila brain disrupts different aspects of sleep and circadian rhythms.
• Juusola M () Binocular Mirror-Symmetric Microsaccadic Sampling Enables Drosophila Hyperacute 3D-Vision. Proceedings of the National Academy of Sciences.

Chapters

• Juusola M, Song Z & Hardie R (2022) Phototransduction Biophysics, Encyclopedia of Computational Neuroscience (pp. 2758-2776).
• Juusola M, Song Z & Hardie R (2015) Phototransduction Biophysics, Encyclopedia of Computational Neuroscience (pp. 2359-2376). Springer New York
• Juusola M, Song Z & Hardie R (2013) Phototransduction Biophysics, Encyclopedia of Computational Neuroscience (pp. 1-20). Springer New York

Conference proceedings papers

• Friederich U, Billings SA, Juusola M & Coca D (2013) We now know what fly photoreceptors compute. BMC Neuroscience, Vol. 14(S1)
• Friederich U, Billings SA, Juusola MA & Coca D (2012) Reverse engineering gain adaptation in sensory systems. Proceedings of the 9th IASTED International Conference on Biomedical Engineering, BioMed 2012 (pp 420-425)
• Billings SA, Song Z, Postma M, Chen W, Coca D, Hardie RC, Juusola M & De Schutter E (2011) Does Calcium diffusional feedback lead to slow light adaptation in Drosophila photoreceptors—a 3D biophysical modelling approach. Computational and System Neuroscience Conf
• Gonzalez-Bellido PT, Kostyleva R, Juusola M, Wardill TJ & Meinertzhagen IA (2009) Dissecting the resolution of a fruit fly retina. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, Vol. 153A(2) (pp S54-S55)
• Gonzalez-Bellido PT, Juusola M, Kostyleva R, Meinertzhagen IA & Wardill TJ (2009) Dissecting the resolution of a fruit fly retina. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, Vol. 153A(2) (pp S157-S157)
• Wardill TJ & Juusola MI (2009) Exploring visual motion circuitry in Drosophila with ultraviolet light. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, Vol. 153A(2) (pp S158-S158)
• Friederich U, Coca D, Billings S & Juusola M (2009) Data Modelling for Analysis of Adaptive Changes in Fly Photoreceptors. NEURAL INFORMATION PROCESSING, PT 1, PROCEEDINGS, Vol. 5863 (pp 34-48) View this article in WRRO
• Song Z, Coca D, Billings SA, Postma M, Hardie RC & Juusola M (2009) Biophysical Modeling of a Drosophila Photoreceptor.. ICONIP (1), Vol. 5863 (pp 57-71) View this article in WRRO
• de Polavieja GG, Harsch A, Robinson H & Juusola M (2005) Slow conductances encode stimulus history into spike shapes. MECHANISMS, SYMBOLS AND MODELS UNDERLYING COGNITION, PT 1, PROCEEDINGS, Vol. 3561 (pp 150-155)

Website content

• Juusola M Home Page.

Preprints

• Juusola M, Takalo J, Kemppainen J, Razban Haghighi K, Scales B, McManus J, Bridges A, MaBouDi H & Chittka L (2024) Theory of Morphodynamic Information Processing: Linking Sensing to Behaviour, MDPI AG.
• Kemppainen J, Mansour N, Takalo J & Juusola M () High-speed imaging of light-induced photoreceptor microsaccades in compound eyes, Cold Spring Harbor Laboratory. View this article in WRRO
• Li X, Tayoun AA, Song Z, Dau A, Rien D, Jaciuch D, Dongre S, Blanchard F, Nikolaev A, Zheng L , Bollepalli MK et al () Ca2+-activated K+ channels reduce network excitability, improving adaptability and energetics for transmitting and perceiving sensory information, Cold Spring Harbor Laboratory.
• Juusola M, Dau A, Song Z, Solanki N, Rien D, Jaciuch D, Dongre S, Blanchard F, de Polavieja GG, Hardie RC & Takalo J () Microsaccadic sampling of moving image information provides Drosophila hyperacute vision, Cold Spring Harbor Laboratory.