Mass spectrometry (MS) is an essential technology driving research across the School, enabling detailed analysis of proteins and metabolites to unravel biochemical pathways. This new instrument combines exceptional speed and sensitivity, significantly enhancing analytical capabilities. In contrast to current equipment, this system features high resolution Mass Spectrometry imaging which allows researchers to pinpoint the spatial distribution of molecules within tissue samples - a major advantage for understanding complex biological systems.
The addition of the Bruker tims TOF fleX MALDI-2 high resolution mass spectrometer to our facility significantly increases our research capabilities. Its ability to image down to single cell level paves the way for groundbreaking insights into the complexities of biological systems.
Dr Heather Walker
biOMICS Mass Spectrometry Technical Specialist
By investing in this advanced technology, the School of Biosciences ensures it remains a leader in innovative molecular research, meeting the rising demand for more detailed and sophisticated MS data.
Professor Sheila Francis from the School of Medicine and Population Health has already begun using the instrument to explore the link between heart disease and dementia. Her research aims to investigate lipid compositions in various regions of the brain to better understand these interconnected conditions.
"We can use MALDI imaging to look at interacting micro-organisms, or at a host-pathogen interaction, or at a cellular component and measure where and which metabolites are changing to start to unpick some fundamental and incredible aspects of biology that were previously very challenging to measure.’
‘Examples would be what attracts fungal hyphae to a root, or what metabolites facilitate a dangerous pathogen to enter into a cell, or how metabolites organise at the site of cell division. This could provide us with knowledge on how to treat certain diseases, information on developmental disorders, or cancer growth that might point towards avenues of intervention, or the ability to promote (or reduce) fungal symbiosis for improved crop performance.”
Dr Alex Williams
School of Biosciences
For further enquiries about the biOMICS Facility contact biomics@sheffield.ac.uk