Professor Ivan Minev

School of Electrical and Electronic Engineering

Visiting Professor

i.minev@sheffield.ac.uk

Amy Johnson Building

Full contact details

Professor Ivan Minev
School of Electrical and Electronic Engineering
Amy Johnson Building
Portobello Street
Sheffield
S1 3JD

Profile

Ivan Minev is Professor of ‘Electronic Tissue Technologies’ at the Else Kröner Fresenius Center for Digital Health at the Medical Faculty of TU Dresden since 2023. He holds a joint appointment at the Leibniz Institute for Polymer Research Dresden, where he is head of a research department. Between 2019 and 2023 he was professor of Intelligent Healthcare Technologies at the Automatic Control and Systems Engineering Department at the University of Sheffield. He obtained his PhD with a thesis ‘Soft Neural Interfaces’ from the University of Cambridge in 2012. His work focuses on the development of materials, devices and systems for bioelectronic medicine.

Professor Minev is working on the development of bioelectronic interfaces. These are devices that establish a communication channel between living and electronic systems. In his recent work he has used 3D printing technology and soft conductive materials to fabricate electrode arrays for implantable, wearable and cell culture applications. This has enabled the recording of biopotentials from the surface of the brain, cell cultures and from muscles. The recorded signals contain a wealth of information about the state of the interfaced biological system. They can potentially be used as diagnostic biomarkers or as control signals in neuroprostheses. The aim of collaboration with SoEEE is to explore the datasets available from this experimental work and to establish if advanced signal processing methods and machine learning can be applied to extract useful information.

Research interests

Bioelectronic implants improve the lives of countless individuals through diagnostic or prosthetic functions. Beyond the success of cardiac pacemakers, cochlear implants or deep brain stimulation, many more therapeutic applications in the nervous and cardiovascular systems remain unexplored. Making the most out of these opportunities will depend on implantable systems that can record and stimulate neural activity and integrate seamlessly with soft tissues in the body.

My group is working on:

Building sensor-actuator networks to enable listening and speaking to the nervous system in several “languages”. We treat the nervous system not only as an electrical, but also as a chemical, thermal and optical machine.
Development of 3D printing technologies for the physical realization of implantable bioelectronic devices and soft robots.
Novel biomaterials (e.g. hydrogels) for engineering the interaction between implant and host tissue.

Publications

Journal articles

Minev IR (2023) Electronic tissue technologies for seamless biointerfaces. Journal of Polymer Science.
Clayton Da Silva A, Akbar TF, Paterson TE, Werner C, Tondera C & Minev IR (2022) Electrically controlled click‐chemistry for assembly of bioactive hydrogels on diverse micro‐ and flexible electrodes. Macromolecular Rapid Communications.
Paterson TE, Hagis N, Boufidis D, Wang Q, Moore SR, Da Silva AC, Mitchell RL, Alix JJP & Minev I (2022) Monitoring of hand function enabled by low complexity sensors printed on textile. Flexible and Printed Electronics, 7(3). View this article in WRRO
Da Silva AC, Wang J & Minev IR (2022) Electro-assisted printing of soft hydrogels via controlled electrochemical reactions. Nature Communications, 13(1).
Habelt B, Wirth C, Afanasenkau D, Mihaylova L, Winter C, Arvaneh M & Bernhardt N (2021) A multimodal neuroprosthetic interface to record, modulate and classify electrophysiological biomarkers relevant to neuropsychiatric disorders. Frontiers in Bioengineering and Biotechnology, 9. View this article in WRRO
Athanasiadis M, Afanasenkau D, Derks W, Tondera C, Murganti F, Busskamp V, Bergmann O & Minev IR (2020) Printed elastic membranes for multimodal pacing and recording of human stem-cell-derived cardiomyocytes. npj Flexible Electronics, 4(1). View this article in WRRO
Habelt B, Arvaneh M, Bernhardt N & Minev I (2020) Biomarkers and neuromodulation techniques in substance use disorders. Bioelectronic Medicine, 6(1). View this article in WRRO
Tondera C, Akbar TF, Thomas AK, Lin W, Werner C, Busskamp V, Zhang Y & Minev IR (2019) Highly conductive, stretchable, and cell‐adhesive hydrogel by nanoclay doping. Small, 15(27). View this article in WRRO
Athanasiadis M, Pak A, Afanasenkau D & Minev IR (2019) Direct writing of elastic fibers with optical, electrical, and microfluidic functionality. Advanced Materials Technologies, 4(7). View this article in WRRO
Xu Y, Patsis PA, Hauser S, Voigt D, Rothe R, Günther M, Cui M, Yang X, Wieduwild R, Eckert K , Neinhuis C et al (2019) Cytocompatible, injectable, and electroconductive soft adhesives with hybrid covalent/noncovalent dynamic network. Advanced Science, 6(15). View this article in WRRO
Wenger N, Moraud EM, Gandar J, Musienko P, Capogrosso M, Baud L, Le Goff CG, Barraud Q, Pavlova N, Dominici N , Minev IR et al (2016) Spatiotemporal neuromodulation therapies engaging muscle synergies improve motor control after spinal cord injury. Nature Medicine, 22(2), 138-145.
Sakuma M, Minev IR, Gribi S, Singh B, Woolf CJ & Lacour SP (2015) Chronic Electrical Nerve Stimulation as a Therapeutic Intervention for Peripheral Nerve Repair. Bioelectronic Medicine, 2(1), 43-48.
Minev IR, Musienko P, Hirsch A, Barraud Q, Wenger N, Moraud EM, Gandar J, Capogrosso M, Milekovic T, Asboth L , Torres RF et al (2015) Electronic dura mater for long-term multimodal neural interfaces. Science, 347(6218), 159-163.
Minev IR, Wenger N, Courtine G & Lacour SP (2015) Research Update: Platinum-elastomer mesocomposite as neural electrode coating. APL Materials, 3(1), 014701-014701.
Borton D, Bonizzato M, Beauparlant J, DiGiovanna J, Moraud EM, Wenger N, Musienko P, Minev IR, Lacour SP, Millán JDR , Micera S et al (2014) Corticospinal neuroprostheses to restore locomotion after spinal cord injury. Neuroscience Research, 78, 21-29.
Chew DJ, Zhu L, Delivopoulos E, Minev IR, Musick KM, Mosse CA, Craggs M, Donaldson N, Lacour SP, McMahon SB & Fawcett JW (2013) A Microchannel Neuroprosthesis for Bladder Control After Spinal Cord Injury in Rat. Science Translational Medicine, 5(210), 210ra155-210ra155.
Vandeparre H, Liu Q, Minev IR, Suo Z & Lacour SP (2013) Localization of Folds and Cracks in Thin Metal Films Coated on Flexible Elastomer Foams. Advanced Materials, 25(22), 3117-3121.
Minev IR, Moshayedi P, Fawcett JW & Lacour SP (2013) Interaction of glia with a compliant, microstructured silicone surface. Acta Biomaterialia, 9(6), 6936-6942.
Delivopoulos E, Chew DJ, Minev IR, Fawcett JW & Lacour SP (2012) Concurrent recordings of bladder afferents from multiple nerves using a microfabricated PDMS microchannel electrode array. Lab on a Chip, 12(14), 2540-2540.
Minev IR, Chew DJ, Delivopoulos E, Fawcett JW & Lacour SP (2012) High sensitivity recording of afferent nerve activity using ultra-compliant microchannel electrodes: an acutein vivovalidation. Journal of Neural Engineering, 9(2), 026005-026005.
Dansachmuller M, Minev I, Schwodiauer R, Bauer-Gogonea S & Bauer S (2011) Discharge of ferroelectrets upon ionizing alpha-radiation. IEEE Transactions on Dielectrics and Electrical Insulation, 18(1), 64-68.
Minev IR & Lacour SP (2010) Impedance spectroscopy on stretchable microelectrode arrays. Applied Physics Letters, 97(4), 043707-043707.
Habelt B, Wirth C, Afanasenkau D, Mihaylova L, Winter C, Arvaneh M, Minev IR & Bernhardt N () A multimodal neuroprosthetic interface to record, modulate and classify electrophysiological correlates of cognitive function. View this article in WRRO
Afanasenkau D, Kalinina D, Lyakhovetskii V, Tondera C, Gorsky O, Moosavi S, Pavlova N, Merkulyeva N, Kalueff AV, Minev IR & Musienko P () Rapid prototyping of soft bioelectronic implants for use as neuromuscular interfaces. Nature Biomedical Engineering.

Chapters

Akbar TF, Tondera C & Minev I (2020) Conductive Hydrogels for Bioelectronic Interfaces, Neural Interface Engineering (pp. 237-265). Springer International Publishing
Minev IR & Lacour SP (2016) Mechanically Compliant Neural Interfaces, Stretchable Bioelectronics for Medical Devices and Systems (pp. 257-273). Springer International Publishing

Conference proceedings papers

Cyganowski A, Minev IR, Vachicouras N, Musick K & Lacour SP (2012) Stretchable electrodes for neuroprosthetic interfaces. 2012 IEEE Sensors, 28 October 2012 - 31 October 2012.
Delivopoulos E, Minev IR & Lacour SP (2011) Evaluation of negative photo-patternable PDMS for the encapsulation of neural electrodes. 2011 5th International IEEE/EMBS Conference on Neural Engineering, 27 April 2011 - 1 May 2011.
Minev IR, Chew DJ, Delivopoulos E, Fawcett JW & Lacour SP (2011) Evaluation of an elastomer based gold microelectrode array for neural recording applications. 2011 5th International IEEE/EMBS Conference on Neural Engineering, 27 April 2011 - 1 May 2011.

Grants

European Research Council, Starting Grant, Integrated Implant Technology for Multi-modal Brain Interfaces (IntegraBrain), 2019 – 2024, 1,496,000 €.

Volkswagen Foundation, Freigeist fellowship, Electronic Tissue Technology for Spinal Cord Repair, 2017 – 2021, 920,000 €