Our spinouts

Aclipse Therapeutics

Aclipse Therapeutics is developing two novel and highly differentiated drug candidates as life-changing treatments for patients with severe diseases. M107 is the first potential disease-modifying drug for the treatment of gastroparesis and is preparing to enter its Phase 2 trial. M102 is the first potential targeted medicine for the treatment of sporadic motor neurone disease (MND or ALS) and is preparing to enter its Phase 1 trial. M102 is the subject of an ongoing collaboration between Aclipse and the Sheffield Institute for Translational Neuroscience at the University of Sheffield. Aclipse has licensed intellectual property on M102 from the University of Sheffield.

AegiQ Ltd

Aegiq is a full stack quantum computing and quantum networking company. It is on the mission to deliver the first commercially viable and universal multi-million qubit quantum computer enabled by quantum networking.

The company uses its unique hybrid integrated photonics approach to solve the million-qubit challenge and unlock economies of scale for quantum technology. Already offering a portfolio of products and solutions covering cybersecurity, quantum communications, quantum networking, quantum-enhanced sensing, and quantum computing, Aegiq helps global leaders in R&D, telecom, defence & aerospace, financial and advanced manufacturing sectors stay ahead of the tech curve.

AmpliSci Ltd

AmpliSi provides scalable, safe and sustainable porous silicon technologies for next-gen batteries. Initially focused on high-capacity applications, AmpliSi's beachhead market is electrical vehicles.

Asterion Ltd

Asterion is generating and developing long-acting biopharmaceutical products that can be administered at a lower dose, less frequently and with fewer side effects than existing marketed drugs.

Audaxis Therapeutics, Inc

Audaxis Therapeutics is transforming women’s pelvic health with fascia-inspired, science-driven, next-generation technology - delivering a safer, more biocompatible implanted solution for Stress Urinary Incontinence (SUI) and beyond.

BlackfinBio Ltd

BlackfinBio is a biotechnology company committed to developing next-generation gene therapies. Our mission is to bring hope, healing and life-changing benefits to patients living with rare and other diseases of the Central Nervous System.

Bettering  Our Worlds (BOW) Ltd

BOW explores the power of robotics, and how it can be used to transform our lives.

CCU International Ltd

CCU International's patented carbon capture technologies help businesses achieve their carbon reduction goals.

Crucible Therapeutics Ltd

Crucible is a biotechnology company developing novel therapies to treat the most common genetic form of motor neurone disease (MND), amyotrophic lateral sclerosis (ALS), and frontotemporal dementia (FTD).

DigitalCNC Ltd

DigitalCNC provides AI-powered software to analyse and optimise machining toolpaths. Their tools can be fully integrated with existing CAD systems, enabling faster, smarter and more accurate CNC operations.

Diurnal Ltd

Diurnal is developing a novel approach to drug delivery that will help patients suffering from reduced levels of the key hormone cortisol (hydrocortisone).

Evolutor Ltd

Evolutor is a biotechnology company building vital infrastructure to produce market-leading microbial production hosts for the sustainable biomanufacture of chemicals, fuels, materials, food ingredients and beyond.

The company is developing proprietary technologies and molecular tools to fully harness the innate power of evolution for industrial use. Evolutor's ambition is to build the world's first massively parallelized evolutionary bio-foundry in Sheffield.

Exciting Instruments Ltd

Exciting Instruments aims to democratise single-molecule fluorescence spectroscopy, making this powerful technique accessible to a wider range of researchers. Their innovative tools reduce complexity and improve ease of use, accelerating scientific discovery across diverse fields like environmental testing, medical diagnostics, and fundamental research. Exciting Instruments offers a cutting-edge instrument with intuitive software for real-time data analysis and visualization.

FourJaw Manufacturing Analysis Ltd

FourJaw delivers accessible technology that empowers manufacturers to achieve their productivity potential. FourJaw is the industry's most accessible and affordable manufacturing analytics software platform. 

Geoptic Infrastructure Investigations Ltd

Geoptic is a spinout company from the collaboration of three UK universities with the founders’ expertise spanning geophysics, applied nuclear, and particle physics. Geoptic utilises highly-penetrating cosmic ray particles, known as muons, in a method similar to the use of x-rays in the medical industry. This method, known as muon tomography, exploits naturally-occurring radiation to image otherwise difficult to access objects in a non-invasive and non-destructive manner. 

Geoptic has successfully applied their novel instrumentation and technique to infrastructure imaging as a means of identifying, locating, and characterising hidden voiding and shafts in the overburden of railway tunnels. This innovative technique is revolutionising remedial tunnel investigations across the UK rail network. 

Instruct3D

Instruct3D provides smart build files that increase the ability, efficiency and reliability of the additive manufacturing process. Its IP-rich software blends physics-based and data-driven simulations to improve the quality, productivity, and profitability of manufacturers.

Keapstone Therapeutics Ltd

Keapstone is developing a novel series of small molecule activators of the Nrf2-ARE pathway for neuroprotection in Parkinson’s and amyotrophic lateral sclerosis (ALS).

LimitState Ltd

LimitState specializes in the development of powerful yet easy-to-use software applications which use unique technology to rapidly identify critical collapse mechanisms and associated margins of safety.

Magnomatics Ltd

Magnomatics is a high technology company that develops and manufactures products based on its proprietary groundbreaking magnetic gear technology.

MetalloBio Ltd

MetalloBio is an antimicrobials development company working on antibacterial compounds which work through novel modes of action. Their platform of compounds target: 1) complicated and difficult-to-treat infections and 2) solutions for medical devices such as catheters and orthopaedic implants.

Neuresta Inc

Neuresta is a biopharmaceutical company focused on developing new therapies for chronic pain. Chronic pain affects hundreds of millions of people worldwide. Despite the tremendous socioeconomic impact of chronic pain, few therapeutic options are currently available. Opioid drugs commonly used for pain management are addictive.

Neuresta is committed to addressing this global healthcare problem with science-based innovation. Our mission is to help those suffering from chronic pain by fulfilling the unmet need for effective, safe and non-addictive medications. Since chronic pain is usually localized, we develop local analgesics for strategic treatments of affected areas of the body. Our lead candidates are expected to offer long-lasting pain relief after a single injection without addiction or systemic side effects.

Opteran Technologies Ltd

Opteran is pioneering its radical lightweight, low-cost silicon-based approach to autonomy called Natural Intelligence.

They expect their technology will significantly expand the potential addressable market for autonomy in machines and robotics.

Perlemax Ltd

Perlemax technology enables the super-efficient generation of micro-sized bubbles of gas in a liquid, which can improve productivity and save energy across a wide spectrum of industrial processes.

PH Therapeutics Ltd

PH Therapeutics is developing novel antibody therapies to treat the orphan disease Pulmonary Arterial Hypertension (PAH), a chronic condition with high levels of mortality.

Phase Focus Ltd

Phase Focus, the Sheffield-based microscopy company, raised £3.2m in equity-based funding round in June 2012 to accelerate revenue generation of its revolutionary nanotech imaging and microscopy technology – the Phase Focus Virtual Lens®.

PHAsT Ltd

PHAsT is a cutting-edge biotech company with the mission of replacing fossil-based plastic in the medical supply chain. Their medical-grade materials produced through bacterial fermentation are a sustainable alternative as they are biocompatible, biodegradable and with tailored properties, making them useful to the whole medical sector.

Phlux Technologies Ltd  

Phlux is building high performance infrared sensors for communications, LIDAR and sensing to enable a clean and connected future.

Pixel-Flo Ltd

Pixel-Flo has developed an entirely new process for microLED mass transfer, the critical barrier to making microLEDs available for display screens at mass market price points. While existing mass transfer technologies achieve reasonable instantaneous mass transfer rates, continuous throughput is severely limited by the changing and loading of wafers, stamps and carriers. Pixel-Flo uniquely offers extremely high continuous throughput and scalability to populate the largest panel sizes. 

Plume Biotechnology Ltd

Plume Biotechnology is developing sustainable functional food solutions for the nutrition and beverage market. Our unique biotechnology platform converts industrial waste streams into highly nutritious plant based algal biomass without the need for complex lighting systems. Our novel IP enables us to generate high stability natural colours addressing specific market unmet needs, thus expanding the application space for natural colours in the growing food and beverage sector for our partners.

Enquiries from interested parties may be addressed to CEO Dr Thomas Burns (t.burnsATplumebiotech.com)

Productive Machines Ltd

Productive Machines uses an algorithm to optimise milling machine tool settings (spindle speeds and feed rates) using a digital twin developed in the Advanced Manufacturing Research Centre (AMRC). The technology is unique in the market in being able to identify high-performance stable characteristics and settings that boost manufacturing performance.

PyrOptik Intruments Ltd

PyrOptik offers expert measurement application consultancy, system design and supply to customer specification. We do this by developing novel opto-electronic metrology solutions that survive in the harshest of applications from our team of design engineers which include optics, electronics, mechanics, software and metrology analysis specialists. 

The company was founded to provide best in class non-contact optical measurement solutions addressing unmet or inadequately serviced measurement challenges in specific industrial and academic niches 

PyrOptik believes in a research led approach to developing products working closely with end users to fully understand the benefits of data to improving the process being analysed. A key guiding philosophy for the company is we believe improved instrumentation and subsequent measurements will allow improved energy efficiency and consequently reduced carbon emissions. 

Regenerative Cell Therapy Consulting Ltd

Regenerative Cell Therapy Consulting (Regen CTC) is a network of UK academic experts with real world experience of translating human pluripotent stem cell (hPSC)-derived cell therapies to the clinic.

Established under the UK Regenerative Medicine Platform in 2018, Regen CTC’s members include fundamental scientists, manufacturing engineers, clinicians and expert translational scientists with experience in developing quality management systems, clean room operations and process development of research protocols.

Our mission is to use our knowledge and experience to accelerate your cell and gene therapy developmental pipeline, helping you to avoid common pitfalls. In so doing, our translational consultants hope to be able to assist advanced therapy developers to deliver their complex therapies to the clinic so that the patients who need them can begin to see their benefits.

ReNewFood Ltd  

Taste and nutritional quality of alternative foods are top priorities for consumers seeking new, great-tasting, healthy food products that are good for our planet. Many traditional foods we have eaten for centuries are derived from natural fermentation. ReNewFood is harnessing nature’s fermentation process to bring a whole new palette of flavour proteins to enhance new alternative foods. Reliability of supply for your raw materials has never been more critical; we bring naturally-sourced flavours with supply consistency.

Rinri Therapeutics Ltd

Rinri Therapeutics is a biotechnology research and development company engaged in the product development of advanced therapies to treat hearing loss. 

RNA Forge Ltd

RNA Forge bridges the critical gap in mRNA drug development by combining deep technical expertise with cutting edge manufacturing and analytical capabilities to accelerate their path from research to patient impact.

Sansanima Ltd

Sansanima is developing in vitro, cell-based assay technologies for the replacement of animal testing in the manufacture of clostridial neurotoxin-based medical products.

SilViA Bio Ltd

SilViA Bio deconstructs and analyses cell factories, identifying limiting bioproduction parameters and offering solutions to take biomanufacturing to the next level. Initially focusing on CHO cells, their technology can be applied to a variety of other cell lines, including HEK and other mammalian strains.

SynGenSys Ltd

SynGenSys's integrated suite of bioinformatics analysis, data modelling, sequence design and component testing modules enables rapid engineering of customised genetic elements for diverse biomedical applications.

Zilico Ltd

Zilico’s Electrical Impedance Spectroscopy (EIS) technology is incorporated into ZedScan, a post-screening cervical cancer diagnostic system that is more accurate than incumbent techniques and provides real-time information to the clinician enabling better patient management at the first appointment.

You can access our online licensing portal here.