Wellcome Trust

We are grateful for the Wellcome Trust for sponsoring the ground-breaking hearing research here at the University of Sheffield.

Some of the recent hearing research lab publications they have supported include:

2022

• AAV-mediated rescue of Eps8 expression in vivo restores hair-cell function in a mouse model of recessive deafness.

2021

• MET currents and otoacoustic emissions from mice with a detached tectorial membrane indicate the extracellular matrix regulates Ca²⁺ near stereocilia

• Biophysical and morphological changes in inner hair cells and their efferent innervation in the ageing mouse cochlea

• Sensory adaptation at ribbon synapses in the zebrafish lateral line

2020

• Pathophysiological changes in inner hair cell ribbon synapses in the ageing mammalian cochlea

• Age-related changes in the biophysical and morphological characteristics of mouse cochlear outer hair cells

2019

• Coordinated calcium signalling in cochlear sensory and non-sensory cells refines afferent innervation of outer hair cells

• Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation