Nikolaev lab

In the Nikolaev lab, we are interested in understanding how the auditory and visual information from the outside world are combined and compared in the brain to allow animals to perform day-to-day tasks, such as localisation of moving objects and social interaction.

Lab Leader:

Anton Nikolaev lab photo

Dr Anton Nikolaev

Lecturer in Neuroscience

School of Biosciences
Development, Regeneration and Neurophysiology

a.nikolaev@sheffield.ac.uk
+44 114 222 5113

Lab Members:

Iqra Hussain

Iqra Hussain

ihussain14@sheffield.ac.uk

PhD Student

My PhD research explores how signalling pathway dynamics differ between cancer-associated fibroblasts and normal fibroblasts in human breast cancer. Using long-term live-cell fluorescent imaging, I analyse ERK, NF-κB, and STAT responses to tumour-relevant growth factors across patient-derived fibroblasts. This work aims to characterise CAF heterogeneity and identify signalling behaviours that drive tumour–stroma interactions.

Lab Collaborations:

In collaboration with another member of our department, Dr Paul Gokhale, we are trying to build very simple neural circuits with given properties (e.g. logical AND, logical NOT etc.) out of cancer stem cells (NT-2 and Neuroblastoma cell lines) differentiated into neurons. We would like to optimise the conditions of differentiation into different types of neurons, make cells grow axons in a particular direction and form synapses with particular neurons in a controlled way. 

Past Lab Members:

1. Sandra Toledo Rivera

2. Katharina Bergmann

3. Konstantinos Lygdas

4. Elliot Birkett: Studying integration on visual and olfactory information in the zebrafish brain.  

5. Berardo Manuel Sanchez Tafolla

6. Heather McCourty

7. Jianbo Zhou