Sheffield publications in translational and precision cancer medicine
Our research integrates genomic profiling within the patient’s cancer journey, from the initial suspicion of cancer through clinical investigations, diagnosis and treatment. Genomic profiling can predict how cancers will grow and which treatments might work best for an individual. We reveal insights into the role and opportunities of modern genomics in cancer care, offer patients the opportunity to take part in the next generation of pharmaceutical studies and feed into discovery and molecular research in the University.
Publications
Journal articles
- A multimodal explainable ai framework to assist in the differential diagnosis of head and neck reactive follicular hyperplasia and follicular lymphoma: an international multicentre study. Virchows Archiv. View this article in WRRO
- A bioactive hydrogel harnessing the regenerative potential of notochordal cells serves as instructive cell carrier for nucleus pulposus repair. Biomaterials, 328, 123895-123895.
- Thermal and chemical control of emission and excited-state dynamics in non-(TMS)3P-derived InP quantum dots.. J Chem Phys, 164(14).
- A Decade of Leadership and Impact: Celebrating 10 Years of the ORS Spine Section. JOR SPINE, 9(2).
- EX VIVO EXPLORATION OF PCRX-201 IN HUMAN KNEE OSTEOARTHRITIS TISSUES. Osteoarthritis and Cartilage, 34, S315-S315.
- Using Mesendoderm Progenitor Cells Seeded in Hydrogel Biomaterial as a strategy to Regenerate the Intervertebral disc. Osteoarthritis and Cartilage, 34, S316-S317.
- Secretome and Pathway Analysis of Stress Induced Disc Degeneration In Vitro. JOR SPINE, 9(2).
- A Network-Based Approach to Understanding Key Signaling Pathways in Intervertebral Disc Biology. JOR SPINE, 9(2).
- Proton-coupled electron transfer from the hydride perspective: resolving metal oxidation and protonation in a hydridocarbonyl complex by 2D-IR spectroelectrochemistry. The Journal of Physical Chemistry Letters, 17(10), 3008-3012. View this article in WRRO
- Co-solute Effects Reveal the Nature of Weak Forces Governing GLP-1 Oligomers Stability. Journal of Biological Chemistry, 111223-111223.
- Complex Mechanical Loading and Pro‐Inflammatory Cytokines in Intervertebral Disc Degeneration. JOR SPINE, 9(1).
- Oropharyngeal squamous cell carcinoma associated with human papilloma virus. Dental Update, 53(1), 46-52.
- Differential diagnosis of blistering disorders presenting in the oral cavity. Diagnostic Histopathology.
- Protocol to identify mechanosensitive nuclear proteins using tunable actomyosin contractility and proximity biotinylation in mammalian cells. STAR Protocols, 7(1), 104288-104288.
- Understanding the Physiological Behavior of Disc Cells in an In Vitro Imitation of the Healthy and Degenerated Disc Niche.. JOR Spine, 8(4), e70153.
- Nanoparticle platforms for encapsulation of therapeutic deep eutectic systems to target colorectal cancer cells. Journal of Drug Delivery Science and Technology, 114, 107517-107517.
- Analysis of mRNA multimerisation (aggregation) using non-denaturing ion-pair reversed-phase liquid chromatography. Journal of Chromatography A, 466653-466653.
- Intracellular Detection of
C. acnes
and
S. aureus
in Non‐Herniated Human Intervertebral Discs: Implications for Catabolic Signaling Pathways. JOR SPINE, 8(4).
- Editorial: In vitro transcription (IVT) reaction – the gateway to new therapeutic modalities. Frontiers in Molecular Biosciences, 12. View this article in WRRO
- Turning the tide: harnessing vaccines and viruses to fight cancer. Immunotherapy Advances. View this article in WRRO
- Base-Mediated Annulation Strategy to Naphthol Boronic Ester Derivatives.. J Org Chem.
- DEVELOPMENT OF AN EX VIVO OSTEOARTHRITIC KNEE MODEL. Orthopaedic Proceedings, 107-B(SUPP_9), 82-82.
- SIMULATING INTRACELLULAR SIGNALLING PATHWAYS IN INTERVERTEBRAL DISC HOMEOSTASIS AND DEGENERATION. Orthopaedic Proceedings, 107-B(SUPP_9), 54-54.
- Dynamics of the CD9 interactome during bacterial infection of epithelial cells by proximity labelling proteomics. The FEBS Journal. View this article in WRRO
- Pathologist-like explainable AI for interpretable Gleason grading in prostate cancer. Nature Communications, 16(1). View this article in WRRO
- P12.58.A ROLE OF IL-33/ST2 AXIS IN GLIOBLASTOMA DEVELOPMENT AND ITS RESPONSE TO TREATMENT. Neuro-Oncology, 27(Supplement_3), iii130-iii130.
- Harnessing Artificial Intelligence in Head and Neck Oncology Practice. Otolaryngologic Clinics of North America.
- Surgical Interventions Improve Survival in Patients with Metastatic Uveal Melanoma. Clinical Surgical Oncology, 100102-100102.
- RACE AND ‘OMIC’ DATA IN GLIOMA: A SYSTEMATIC REVIEW OF CONTEMPORARY RESEARCH TO EXPLORE THE DIGITAL DIVIDE. Neuro-Oncology, 27(Supplement_2), ii29-ii29.
- 144P Beyond markers: Functional assays and transcriptomics reveal CSC populations in soft tissue sarcomas. ESMO Open, 10, 105721-105721.
- Circular dichroism and multiphoton circularly polarized luminescence switching using a bis‐perylene diimide macrocycle. Chemistry – A European Journal. View this article in WRRO
- Ex vivo drug screening and clustering of bladder cancers for pre-clinical treatment prediction. Communications Medicine.
- Innovations in biomarker stratification for precision oncology. Clinical and Experimental Medicine.
- Exercise Boosts the Immune System and Enhances Immunotherapy Responses in Pancreatic Cancer and Mesothelioma. Biomolecules, 16(4), 493-493.
- Mapping Epidermal Growth Factor Receptor-1 Sorting Domains in Endosomes with a Calibrated Three-Dimensional Expansion Microscopy Toolkit. ACS Nano.
- Tissue Damage in Rheumatoid Arthritis is Genetically linked to Low Peptidylglycine Alpha‐Amidating Monooxygenase Activity in Synovial Fibroblasts. Arthritis & Rheumatology.
- Nervous System-on-Chip: Innovative Microfluidic Platform to Compartmentalize hiPSC-Derived Neural Networks. Micromachines, 17(2), 199-199.
- Childhood outcomes in children with Hirschsprung disease: a population-based data linkage study in England. Frontline Gastroenterology.
- Resolving consecutive excited-state evolution in Fe-amido chromophores by wide-band optical transient absorption spectroscopy. Chemical Science.
- Independent Multicentre Validation of the ‘Six‐Point’ Model for Malignant Transformation Risk in Oral Epithelial Dysplasia. Oral Diseases.
- Effect of a Peripheral Substituent on the Ultrafast Dynamics and the rate of Intersystem Crossing in charge-transfer states of Platinum(II) acetylides. Physical Chemistry Chemical Physics.
Conference proceedings
- In-depth characterization of the colonic pathology of the B6;129-Ednrbtm1Ywa/J mouse model of Hirschsprung disease and stem cell-based rescue. NEUROGASTROENTEROLOGY AND MOTILITY, Vol. 37
Other
Preprints
- Dynamic modelling of human neural crest development using a bioengineered stem cell organoid system, openRxiv.
- Notch signalling governs human enteric nervous system progenitor dynamics, openRxiv.
- Estrogen prevents anti-tumor effects of Zoledronic acid in breast cancer through the NK and CD8+T cell PD-1/PD-L1 axes, Springer Science and Business Media LLC.
- Generation of human hindlimb/genital tubercle progenitors from pluripotent stem cells, openRxiv.
- A bipartite mechanism for condensin II activation in mitosis, openRxiv.
- Bone Recovery After Treatment Study (BRATS) - A Protocol for a Prospective, Observational Study in Multiple Myeloma, openRxiv.
- Binding Kinetics Oppositely Regulates type II Topoisomerase Relaxation and Decatenation Activities, openRxiv.
- Understanding the physiological behaviour of disc cells in an
in vitro
imitation of the healthy and degenerated disc niche, openRxiv.
- Childhood outcomes in children with Hirschsprung disease: a population-based data linkage study in England, Cold Spring Harbor Laboratory.
- Functional and molecular rescue of aganglionic colon by human enteric nervous system progenitor transplantation in Hirschsprung disease, Cold Spring Harbor Laboratory.
- Analysis of mRNA multimerisation (aggregation) using non-denaturing ion-pair reversed-phase HPLC, American Chemical Society (ACS).
- Mapping EGFR1 sorting domains in endosomes with a calibrated 3D expansion microscopy toolkit, Cold Spring Harbor Laboratory.
- An unbiased screening approach for identifying proteins with a mechanosensitive nuclear localization, Cold Spring Harbor Laboratory.