Sheffield publications in improving outcomes for cancer patients
The vision is to discover new treatments or better ways of giving current treatments, as well as develop new methodology for matching treatment to patients’ individual cancers. This theme encompasses discovery science – identifying new molecules and mechanisms; therapeutic innovation – developing novel treatments and combinations; and precision oncology – improving patient selection to optimise therapeutic response.
Publications
Journal articles
- A multimodal explainable ai framework to assist in the differential diagnosis of head and neck reactive follicular hyperplasia and follicular lymphoma: an international multicentre study. Virchows Archiv. View this article in WRRO
- Loss of Cathepsin Z enhances pro-inflammatory macrophage responses and promotes tissue regeneration in zebrafish. Disease Models & Mechanisms, dmm.052520.
- Equity impact and cost-effectiveness of a community health worker breast cancer educational programme in rural South Africa: a modelling study. BMJ Open, 16(4). View this article in WRRO
- Factors Affecting Nurses, Midwives and Allied Health Professionals' Ability to Engage With Research.. J Clin Nurs.
- Effectiveness of non-pharmacological interventions for fatigue in long term conditions: systematic review and network meta-analysis. BMJ Medicine, 5(1), e001746-e001746.
- Immune-adaptive pathogen variation reveals targetable mediators of gram-positive bacterial killing in macrophages.. Sci Adv, 12(9), eaea0375.
- Ten Recommendations for Modelling Cost Effectiveness of Screening: Perspectives of an International Stakeholder Group.. Pharmacoeconomics.
- Removal of small fibroids and polyps in patients with infertility and recurrent miscarriage: The HELP Fertility? RCT.. Health Technol Assess, 1-35.
- 3D environment favors persistent changes in cell functions and altered morphology, wrinkling, and biomechanical signature of the nucleus. Cell Reports Physical Science, 7(2), 103116-103116.
- Doxorubicin induces bone loss and modifies multiple cell populations in vivo – Implications for modelling of bone metastasis. Journal of Bone Oncology, 56, 100736-100736.
- KG-Retailbot: A knowledge graph-based chatbot for explaining robotic scenario information in a retail setting. International Journal of Social Robotics, 18(1). View this article in WRRO
- Protocol to identify mechanosensitive nuclear proteins using tunable actomyosin contractility and proximity biotinylation in mammalian cells. STAR Protocols, 7(1), 104288-104288.
- Barriers and facilitators to prostate cancer healthcare in Black men in the UK: from diagnosis to survivorship. Journal of Cancer Survivorship. View this article in WRRO
- The importance of highlighting effective practice. Nursing Management, 32(6), 15-15.
- HTA335 The Use of Real-World Evidence in Health Technology Assessment and the Application of the NICE RWE Framework: A Review of NICE Technology Appraisals. Value in Health, 28(12), S471-S472.
- Evidence-biased medicine? Applying a health equity lens to Sackett's methodological framework. British Journal of General Practice, 75(761), 574-578. View this article in WRRO
- Ras signalling at the actin cortex: Coordinating local and global changes to cell morphology. Current Opinion in Cell Biology, 97, 102600-102600.
- Correction: A subset of neutrophil phagosomes is characterised by pulses of Class I PI3K activity. Disease Models & Mechanisms, 18(10).
- Development of a community research link worker role to enable culturally tailored research and empower marginalised communities to participate: the IBISES model. Research Involvement and Engagement, 11. View this article in WRRO
- Dynamics of the CD9 interactome during bacterial infection of epithelial cells by proximity labelling proteomics. The FEBS Journal. View this article in WRRO
- Hysteresis-assisted shape morphing for soft continuum robots.. Sci Adv, 11(42), eadx3024.
- P12.58.A ROLE OF IL-33/ST2 AXIS IN GLIOBLASTOMA DEVELOPMENT AND ITS RESPONSE TO TREATMENT. Neuro-Oncology, 27(Supplement_3), iii130-iii130.
- Harnessing Artificial Intelligence in Head and Neck Oncology Practice. Otolaryngologic Clinics of North America.
- Surgical Interventions Improve Survival in Patients with Metastatic Uveal Melanoma. Clinical Surgical Oncology, 100102-100102.
- Developing powerful PPIE partnerships in the design of an inclusive weight management service: a case study from the NewDAWN programme. Research Involvement and Engagement, 11. View this article in WRRO
- إنهاء الأسلحة النووية قبل أن تنهي حياتنا. Arabian Journal of Scientific Research-المجلة العربية للبحث العلمي, 2025(2).
- Ending nuclear weapons, before they end us. Internal and Emergency Medicine, 20(6), 1667-1670.
- AHL-based QS signalling promotes uropathogenic Escherichia coli settlement through the de-repression of biofilm formation by SdiA. PLOS One, 20(9). View this article in WRRO
- RACE AND ‘OMIC’ DATA IN GLIOMA: A SYSTEMATIC REVIEW OF CONTEMPORARY RESEARCH TO EXPLORE THE DIGITAL DIVIDE. Neuro-Oncology, 27(Supplement_2), ii29-ii29.
- 144P Beyond markers: Functional assays and transcriptomics reveal CSC populations in soft tissue sarcomas. ESMO Open, 10, 105721-105721.
- Self‐Assessment Organisational Readiness Tool (SORT) for nursing research capacity development: results of a UK Delphi study. International Nursing Review, 72(3). View this article in WRRO
- Health-related Quality of Life in People with Autosomal Dominant Polycystic Kidney Disease: A Systematic Review. Clinical Kidney Journal.
- Evaluating Digital Twin Visualizations for Safety and Trust in Robot-Assisted Dressing. ACM Transactions on Human-Robot Interaction.
- Independent Multicentre Validation of the ‘Six‐Point’ Model for Malignant Transformation Risk in Oral Epithelial Dysplasia. Oral Diseases.
- The PRAMS (Perinatal Redesign for Accessing Mental Health Services) Study: a research protocol. BJGP Open, BJGPO.2025.0206-BJGPO.2025.0206.
- Ten tips on performing economic evaluation in kidney disease. Clinical Kidney Journal.
- Effect of Childhood Exposure to Domestic Violence and Abuse on Adult Relationships: A Mental Health Nurse Perspective. Journal of Psychosocial Nursing and Mental Health Services, 1-8.
- Development, Validation and Effectiveness of Postnatal Care Module for Confinement Ladies: A concept paper. Environment-Behaviour Proceedings Journal, 10(SI35), 177-183.
- Religious and cultural influences on domestic violence attitudes and responses in UK ethnic minority and migrant communities: A qualitative inquiry. Violence: An International Journal.
- Using inverse probability of censoring weighting to estimate hypothetical estimands in clinical trials: Should we implement stabilisation, and if so how?. Statistical Methods in Medical Research.
- Cancer-Associated Fibroblasts Move and Interact More with Triple-Negative Breast Cancer Cells and Stimulate Their Proliferation in a Hyaluronan-Dependent Manner. Cells, 14(21), 1663-1663.
- Integrating Intersectionality Theory for Informing Health Policymaking. World Medical & Health Policy.
- Augmented two-stage estimation for treatment switching in oncology trials: Leveraging external data for improved precision. Statistical Methods in Medical Research.
Book chapters
- Marker density of optical tactile sensor for moving object tracking In Cavalcanti A, Foster S & Richardson R (Ed.), Towards Autonomous Robotic Systems (pp. 54-67). Springer Nature Switzerland View this article in WRRO
- Qualitative evidence synthesis In Facey KM, Holtorf A-P & Single ANV (Ed.), Patient Involvement in Health Technology Assessment (pp. 177-194). Springer Nature Switzerland View this article in WRRO
- Extracellular ATP and the bone, ATP (pp. 521-543). Elsevier
Conference proceedings
- Symbolic Runtime Verification and Adaptive Decision-Making for Robot-Assisted Dressing (pp 290-308)
- SA90 Systematic Review of Doubly Robust Methods for Population-Adjusted Indirect Comparisons. Value in Health, Vol. 28(12) (pp S663-S664)
- MSR214 Using Directed Acyclic Graphs in Matching-Adjusted Indirect Comparison and Simulated Treatment Comparison: Systematic Review and Methodological Insights. Value in Health, Vol. 28(12) (pp S537-S538)
- USING DIRECTED ACYCLIC GRAPHS IN MATCHING-ADJUSTED INDIRECT COMPARISON AND SIMULATED TREATMENT COMPARISON: SYSTEMATIC REVIEW AND METHODOLOGICAL INSIGHTS. VALUE IN HEALTH, Vol. 28(12)
- THE USE OF REAL-WORLD EVIDENCE IN HEALTH TECHNOLOGY ASSESSMENT AND THE APPLICATION THE NICE RWE FRAMEWORK: A REVIEW OF NICE TECHNOLOGY APPRAISALS. VALUE IN HEALTH, Vol. 28(12)
- SYSTEMATIC REVIEW OF DOUBLY ROBUST METHODS FOR POPULATION-ADJUSTED INDIRECT COMPARISONS. VALUE IN HEALTH, Vol. 28(12)
- (ID: 231) ‘Mystery shopper’ blood pressure checks in pharmacies: the patient experience. International Journal of Pharmacy Practice, Vol. 33(Supplement_1) (pp i63-i63)
- Robotic colonoscopy: can high fidelity simulation optimize robot design and validation?. 2025 IEEE International Conference on Robotics and Automation (ICRA) (pp 2954-2960). Atlanta, GA, USA, 19 May 2025 - 19 May 2025. View this article in WRRO
Preprints
- Estrogen prevents anti-tumor effects of Zoledronic acid in breast cancer through the NK and CD8+T cell PD-1/PD-L1 axes, Springer Science and Business Media LLC.
- DNA Damage Driven Viability Loss and Transcriptional Reprogramming in Chinese Hamster Ovary Cell Perfusion Culture, openRxiv.
- Bone Recovery After Treatment Study (BRATS) - A Protocol for a Prospective, Observational Study in Multiple Myeloma, openRxiv.
- Barriers and Facilitators to Prostate Cancer Healthcare in Black Men in the UK: From Diagnosis to Survivorship, Springer Science and Business Media LLC.
- Myosin VI orchestrates estrogen-driven gene expression in breast cancer cells, Cold Spring Harbor Laboratory.
- Siglec-engaging immunosuppressive sialoglycans are upregulated in prostate cancer and are targetable to suppress bone metastasis, openRxiv.
- Verapamil limits inflammation by restoring VGCC-driven epithelial Ca2+ in models of cystic fibrosis, Cold Spring Harbor Laboratory.
- An unbiased screening approach for identifying proteins with a mechanosensitive nuclear localization, Cold Spring Harbor Laboratory.
- Global abuse of older people: A mega‐map of systematic reviews on prevalence, consequences, risk and protective factors and interventions, Center for Open Science.