Sheffield publications in improving outcomes for cancer patients
The vision is to discover new treatments or better ways of giving current treatments, as well as develop new methodology for matching treatment to patients’ individual cancers. This theme encompasses discovery science – identifying new molecules and mechanisms; therapeutic innovation – developing novel treatments and combinations; and precision oncology – improving patient selection to optimise therapeutic response.
Publications
Journal articles
- Effectiveness of non-pharmacological interventions for fatigue in long term conditions: systematic review and network meta-analysis. BMJ Medicine, 5(1), e001746-e001746.
- The SPACES feasibility trial: A co-produced physical activity intervention for people with severe mental illness. Mental Health and Physical Activity, 30, 100765-100765.
- Removal of small fibroids and polyps in patients with infertility and recurrent miscarriage: The HELP Fertility? RCT.. Health Technol Assess, 1-35.
- Variance of the Distance to the Boundary of Convex Domains in R2 and R3. Journal of Optimization Theory and Applications, 208(3).
- Protocol to identify mechanosensitive nuclear proteins using tunable actomyosin contractility and proximity biotinylation in mammalian cells. STAR Protocols, 7(1), 104288-104288.
- Ras signalling at the actin cortex: Coordinating local and global changes to cell morphology. Current Opinion in Cell Biology, 97, 102600-102600.
- Turning the tide: harnessing vaccines and viruses to fight cancer. Immunotherapy Advances. View this article in WRRO
- Oncogenic Ras activation in permissive somatic cells triggers rapid-onset phenotypic plasticity and elicits a tumor-promoting neutrophil response. Cell Reports, 44(11), 116478-116478.
- Dynamics of the CD9 interactome during bacterial infection of epithelial cells by proximity labelling proteomics. The FEBS Journal. View this article in WRRO
- Vitamin D, muscle strength and function in South Asian women aged ≥ 60 years living in the North of England: a cross-sectional observational study. European Journal of Nutrition, 64(7). View this article in WRRO
- How is missing data handled in cluster randomized controlled trials? A review of trials published in the NIHR Journals Library 1997–2024. Clinical Trials. View this article in WRRO
- P12.58.A ROLE OF IL-33/ST2 AXIS IN GLIOBLASTOMA DEVELOPMENT AND ITS RESPONSE TO TREATMENT. Neuro-Oncology, 27(Supplement_3), iii130-iii130.
- Surgical Interventions Improve Survival in Patients with Metastatic Uveal Melanoma. Clinical Surgical Oncology, 100102-100102.
- Developing powerful PPIE partnerships in the design of an inclusive weight management service: a case study from the NewDAWN programme. Research Involvement and Engagement, 11. View this article in WRRO
- Cost-effectiveness of different HPV vaccination strategies for cervical cancer prevention in South Africa. Vaccine, 64, 127770-127770.
- An economic analysis of BPaL for multidrug-resistant TB in South Africa and the Philippines. IJTLD OPEN, 2(9), 535-541. View this article in WRRO
- AHL-based QS signalling promotes uropathogenic Escherichia coli settlement through the de-repression of biofilm formation by SdiA. PLOS One, 20(9). View this article in WRRO
- Mesenteric excision and Kono‐S anastomosis trial (MEErKAT): A study protocol for a multicentre, 2 × 2 factorial, randomised controlled, open‐label superiority trial. Colorectal Disease, 27(9). View this article in WRRO
- RACE AND ‘OMIC’ DATA IN GLIOMA: A SYSTEMATIC REVIEW OF CONTEMPORARY RESEARCH TO EXPLORE THE DIGITAL DIVIDE. Neuro-Oncology, 27(Supplement_2), ii29-ii29.
- 144P Beyond markers: Functional assays and transcriptomics reveal CSC populations in soft tissue sarcomas. ESMO Open, 10, 105721-105721.
- Ex vivo drug screening and clustering of bladder cancers for pre-clinical treatment prediction. Communications Medicine.
- Loss of Cathepsin Z enhances pro-inflammatory macrophage responses and promotes tissue regeneration in zebrafish. Disease Models & Mechanisms.
- Sample size calculations for pilot cluster-randomised controlled trial: a review 2010–2020. Pilot and Feasibility Studies.
- Bracing AdoleScent Idiopathic Scoliosis after skeletal maturity (BASIS 2): study protocol for a randomized controlled trial within a larger trial. Bone & Joint Open, 7(1), 130-137.
- Design, synthesis and biological activity of glycoconjugated ADAMTS5 exosite inhibitors: applications in osteoarthritis and ovarian cancer models. Scientific Reports.
- The PRAMS (Perinatal Redesign for Accessing Mental Health Services) Study: a research protocol. BJGP Open, BJGPO.2025.0206-BJGPO.2025.0206.
- Multiplicity adjustment approaches in publicly funded multi-arm trials: a comprehensive review of the National Institute for Health and Care Research (NIHR) Journals Library. Trials.
- Evidence-biased medicine? Applying a health equity lens to Sackett's methodological framework. BJGP.
- Understanding mechanisms of colorectal cancer chemoprevention using seAFOod polyp prevention trial outcomes and its Biobank: STOP-ADENOMA synopsis. Efficacy and Mechanism Evaluation, 1-20.
- Development of a community research link worker role to enable culturally tailored research and empower marginalised communities to participate: the IBISES model. Research Involvement and Engagement, 11(1).
Book chapters
- Qualitative evidence synthesis In Facey KM, Holtorf A-P & Single ANV (Ed.), Patient Involvement in Health Technology Assessment (pp. 177-194). Springer Nature Switzerland View this article in WRRO
- Development of the semicircular canals and otolithic organs of the vertebrate inner ear In Richardson GP & Wu DK (Ed.), Development of Sensory Organs (pp. 125-184). Elsevier View this article in WRRO
Conference proceedings
- (ID: 231) ‘Mystery shopper’ blood pressure checks in pharmacies: the patient experience. International Journal of Pharmacy Practice, Vol. 33(Supplement_1) (pp i63-i63)
Preprints
- Notch signalling governs human enteric nervous system progenitor dynamics, openRxiv.
- Quantification and statistical comparison of cell-state transition kinetics using a parametric failure-based model, openRxiv.
- Oncogenic RAS-driven α2 integrin induction under nutrient stress promotes cancer cell motility, openRxiv.
- During an inflammatory response, zebrafish tnfa and tnfb are expressed by different cell types and have distinct expression kinetics, eLife Sciences Publications, Ltd.
- During an inflammatory response, zebrafish tnfa and tnfb are expressed by different cell types and have distinct expression kinetics, eLife Sciences Publications, Ltd.
- Metal-catalysed Hydroboration of Amide-containing Styrenes, American Chemical Society (ACS).
- Bone Recovery After Treatment Study (BRATS) - A Protocol for a Prospective, Observational Study in Multiple Myeloma, openRxiv.
- GPU acceleration of cell-based simulations in Chaste using FLAME GPU 2, openRxiv.
- Collagen I promotes cancer cell survival via amino acid import and mTORC1 activation, Cold Spring Harbor Laboratory.
- During an inflammatory response, zebrafish
tnfa
and
tnfb
are expressed by different cell types and have distinct expression kinetics, Cold Spring Harbor Laboratory.
- Beyond pulling: microtubule pushing forces contribute to robust spindle orientation in regular and irregular cell shapes, Cold Spring Harbor Laboratory.
- An unbiased screening approach for identifying proteins with a mechanosensitive nuclear localization, Cold Spring Harbor Laboratory.