Dr Lynne Bingle
BSc (Hons), PhD
School of Clinical Dentistry
Reader in Oral Science
Head Academic Unit of Oral and Maxillofacial Medicine and Pathology
Director of Postgraduate Taught Programmes
+44 114 215 9344
Full contact details
School of Clinical Dentistry
19 Claremont Crescent
Sheffield
S10 2TA
- Profile
-
I am a Reader in the Academic Unit of Oral and Maxillofacial Pathology having joined the School of Clinical Dentistry as a Lecturer in 2005. Prior to this, I spent 7 years as a Research Assistant and then Research Fellow at the Medical School here in Sheffield.
Whilst carrying out my PhD in London, under the supervision of Professors Terry Tetley, Bernard Fox and Abe Guz, I developed the first 3D in vitro model of a human pulmonary alveolus; this has shaped much of my research interests as I have gone on to develop in vitro models of the trachea, the nasal cavity, the middle ear and salivary glands. My first post-doctoral position was at Washington University, St Louis Missouri where I spent two years in Robert Senior’s Department working with Erika Crouch on the role of surfactant protein D in lung immunity. I returned to the UK and had a post-doctoral position with Professor Tetley isolating novel proteinase inhibitors from human and sheep lungs (a good model of acute respiratory distress). Then I moved to Sheffield, working initially in the Medical School before being awarded a lectureship in the Dental School.
I have a long-standing collaboration with, and am a visiting Professor at, the Dental School, University of Campinas, Piracicaba in Brazil. I am also a visiting Professor at the Dental School of the Federal University of Minas Gerais in Belo Horizonte and established collaborative links with academic research groups in Sao Paulo and Porto Alegre.
- Research interests
-
My long-standing research interests have focused on the role and regulation of epithelial secretory proteins. This work has principally involved the study of the airway epithelium through 3D in vitro model systems. More recently, it has expanded to include the oral and nasal mucosa and the epithelium of the middle ear. My specific interests have focused on the fields of innate immunity, host defence and tumour biology.
I have also used my tissue culture expertise to develop in vitro models of human salivary glands from fresh human tissue. We are now routinely isolating cells from the human parotid, sublingual and submandibular glands, and adult and foetal tissue, and are characterising cell phenotype under different culture conditions. We are also using these models to study the tumourigenesis in salivary gland cancer by introducing novel fusion genes often found in these glandular tumours.
- Publications
-
Journal articles
- Disruption of oncogenic pathways in mucoepidermoid carcinoma: CREB inhibitor 666.15 as a potential therapeutic agent. Oral Oncology, 159, 107029-107029.
- Effects of CREB inhibitor in mucoepidermoid carcinoma cell lines. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 138(2), e45-e45.
- CREB INHIBITOR THERAPY FOR MUCOEPIDERMOID CARCINOMA.. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 137(6), e291-e291.
- Drug-based therapy for advanced adenoid cystic carcinoma: current landscape and challenges based on an overview of registered clinical trials. Critical Reviews in Oncology/Hematology, 181.
- Pleomorphic adenoma and carcinoma ex‐pleomorphic adenoma tumorigenesis: A proteomic analysis. Oral Diseases.
- Correlation between Matrix Metalloproteinase presence and caries surface appearance. Caries Research.
Conference proceedings papers
- In vitro approaches to identify an antiviral role for BPIFB1 in the airway epithelium. 03.02 - Airway cell biology and immunopathology
- Defining the functions of PIERCE1 and C15ORF65 during ciliogenesis of HBEC3-KT cells. 03.02 - Airway cell biology and immunopathology
- Comparative secretome analysis of differentiated epithelial cells grown at the Air liquid interface (ALI). 03.02 - Airway cell biology and immunopathology
- Defining spatial secretome and ciliome across multiciliated epithelia. 03.02 - Airway cell biology and immunopathology
- Disruption of oncogenic pathways in mucoepidermoid carcinoma: CREB inhibitor 666.15 as a potential therapeutic agent. Oral Oncology, 159, 107029-107029.
- Research group
-
- Isabel Parreira (PhD student; The Pathogenesis of Otitis Media).
- Lin Zhang (PhD student; Functional Analysis of BPIFA2 in Human Saliva).
- Fatima Elalawy (PhD student; The Role of Fusion proteins in the Development of Salivary Gland Tumours).
- Maria Eduardo Perez de Oliveira (PhD student: lead Prof Pablo; Vargas Identification of interacting proteins in salivary gland cells harbouring the CRTC1-MAML2 translocation).
- Vivian Petersen Wagner (Marie Curie Fellow; MYB rearrangements in Adenoid Cystic Carcinoma: protagonists or secondary characters?)
- Teaching activities
-
I teach both first-year BDS modules (DEN 11001 and DEN 11002) and second-year BDS students on the DEN 21001 module. I also teach first-year medical students all years of the BSc Biodental Science and Technology (DEN 123, DEN 124, DEN 223 and DEN 31015).
I am Programme Director for the MMedSci in Diagnostic Oral Pathology course; I lead and teach one of the modules (ORP 607) on this course and teach on ORP 609 and DEN616.
- Professional activities and memberships
-
I am Head of the Academic Unit of Oral and Maxillofacial Medicine and Pathology and Director of Postgraduate Taught courses in the School of Clinical Dentistry. In this latter role, I sit on the Faculty PGT committee, Faculty Learning and Teaching Committee, School Executive Committee and School Teaching committee.
Outside of the University of Sheffield, I am a visiting Professor at the Faculdade de Odontologia de Piracicaba, University of Campinas, Brazil.