Dr Hannah Crane

BMedSci, BDS, MFDS, FHEA, MSc, PhD

School of Clinical Dentistry

NIHR Academic Clinical Lecturer in Oral and Maxillofacial Pathology

h.crane@sheffield.ac.uk

19 Claremont Crescent

Full contact details

Dr Hannah Crane
School of Clinical Dentistry
19 Claremont Crescent
Sheffield
S10 2TA

Profile

Dr Crane was appointed as an NIHR Academic Clinical Lecturer in Oral and Maxillofacial Pathology in December 2023, having recently completed a Wellcome funded Clinical PhD Fellowship investigating treatment resistance in Head and Neck Cancer.

Hannah graduated from the University of Sheffield in 2014, her research interests being sparked whilst undertaking an intercalated BMedSci. After graduation, she completed Dental Foundation Training in South Manchester and Dental Core Training posts in Restorative Dentistry, Oral Medicine and Oral and Maxillofacial Surgery. During this time she successfully obtained a Membership of the Faculty of Dental Surgery (MFDS) from the Royal College of Surgeons Edinburgh. She was appointed as an Academic Clinical Fellow in Oral and Maxillofacial Pathology in 2017 and in 2020 completed a Masters in Clinical Research with Distinction.

Research interests

During her Clinical PhD Fellowship, Dr Crane undertook laboratory research investigating DNA damage in chemotherapy-resistant Head and Neck Cancer. Head and Neck Cancer is associated with significant morbidity and current treatments frequently result in the development of resistance, which can be extremely challenging to treat. She has experience in a broad range of molecular biology techniques, alongside data analysis skills including image analysis using publicly available software such as QuPath and ImageJ. She is also interested in the use of next-generation sequencing to understand complex biological problems.

Dr Crane is passionate about patient and public involvement in research. She regularly involves patients and the public in the development and dissemination of her research. In 2021, she developed an activity for a patient and public event entitled the Pop-Up University, and in collaboration with MakerFutures, she developed activities designed to engage the public about DNA damage and repair.

Publications

Journal articles

Crane H, Walsh H & Hunter KD (2024) Fibro-osseous lesions of the jaws. Diagnostic Histopathology, 30(3), 170-178.
Walsh H, Crane H & Hunter KD (2022) Giant cell lesions of the jaws. Diagnostic Histopathology, 28(5), 217-227.
Karyka E, Berrueta Ramirez N, Webster CP, Marchi PM, Graves EJ, Godena VK, Marrone L, Bhargava A, Ray S, Ning K , Crane H et al (2022) SMN-deficient cells exhibit increased ribosomal DNA damage. Life Science Alliance, 5(8). View this article in WRRO
Crane H, Karbhari B, Hughes D, Orr R & Brierley D (2021) Glandular odontogenic cyst with metaplastic cartilage: report of an unusual case and literature review. Head and Neck Pathology, 15, 1041-1046. View this article in WRRO
Radhakrishnan R, Crane HL, Daigneault M, Padam KSR & Hunter KD (2021) RARβ expression in keratinocytes from potentially malignant oral lesions : the functional consequences of re-expression by de-methylating agents. Cancers, 13(16).
Walsh H, Crane H, Lee NJ & Brierley DJ (2021) AN UNEXPECTED CAUSE OF ULCERATION IN THE ORAL CAVITY. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 132(1), e50-e51.
Crane H, Walsh H, Tailor A & Hunter K (2021) Pseudomalignancies of the head and neck. Diagnostic Histopathology, 27(5), 182-190.
Niklander SE, Crane HL, Darda L, Lambert DW & Hunter KD (2021) The role of icIL-1RA in keratinocyte senescence and development of the senescence-associated secretory phenotype. Journal of Cell Science, 134(4).
Niklander SE, Crane HL, Darda L, Lambert DW & Hunter KD (2020) The role of icIL-1RA type 1 in oral keratinocyte senescence and the development of the senescence associated secretory phenotype.
Crane H, Da Forno P, Kyriakidou E, Speight PM & Hunter KD (2020) Multiple Orthokeratinized Odontogenic Cysts: A Report of Two Cases and Review of the Literature. Head and Neck Pathology, 14(2), 381-385.
Niklander MS, Crane MH, Lambert DD & Hunter PK (2019) INTERLEUKIN 1 RECEPTOR ANTAGONIST (IL-1RA) BIOLOGY IN ORAL EPITHELIUM, ORAL DYSPLASIA AND ORAL SQUAMOUS CELL CARCINOMA. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 128(1), e82-e82.
Crane H, Mustafa S, Tahir F & Brierley DJ (2019) Case report: primary mediastinal germ cell tumour initially presenting as level IV cervical lymphadenopathy. Oral Surgery, 12(4), 309-312.
Brierley DJ, Crane H & Hunter KD (2019) Lumps and bumps of the gingiva : a pathological miscellany. Head and Neck Pathology, 13(1), 103-113. View this article in WRRO
Siriwardena BSMS, Crane H, O'Neill N, Abdelkarim R, Brierley DJ, Franklin CD, Farthing PM, Speight PM & Hunter KD (2019) Odontogenic tumors and lesions treated in a single specialist oral and maxillofacial pathology unit in the United Kingdom in 1992–2016. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 127(2), 151-166.
(2017) Clinical Effectiveness Bulletin. International Journal of Paediatric Dentistry, 27(S1), 42-53.
Crane H, Carter A & Andresen E (2017) A curious case of unexplained physical reaction to dental local anaesthetic. Oral Surgery, 10(4), 239-242.
Hendawi NY, Crane HL, Mehanna H, Bolt R, Lambert DW & Hunter KD () Fibroblasts from HPV-negative oropharynx squamous cell carcinomas stimulate the release of osteopontin from cancer cells via the release of IL-6. Frontiers in Oral Health, 5.

Conference proceedings papers

Crane H, Foran B, Tahir F, Joyce H, El-Khamisy S & Hunter K (2021) CISPLATIN RESISTANCE IN HPV-POSITIVE AND HPV-NEGATIVE OROPHARYNGEAL SQUAMOUS CELL CARCINOMA. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Vol. 132(1) (pp e15-e15)
Niklander S, Crane H, Lambert D & Hunter K (2017) Interleukin 1 receptor antagonist (IL-1RA) expression is progressively lost in oral dysplasia and oral squamous cell carcinoma but the phenotypic consequences are not clear. CYTOKINE, Vol. 100 (pp 185-185)

Preprints

Crane H, Carr I, Hunter KD & El-Khamisy SF (2024) Senataxin modulates resistance to cisplatin through an R-loop mediated mechanism in HPV-associated Head and Neck Squamous Cell Carcinoma, Cold Spring Harbor Laboratory.

Teaching activities

Dr Crane successfully completed a PGCert in Teaching and Learning in Clinical Practice at Edgehill University in 2018 and was subsequently awarded FHEA. She teaches pathology to undergraduate and postgraduate students through lectures, case seminars and virtual microscopy sessions.

She is also involved in the training of postgraduate dentists and facilitates a course for Dental Foundation Trainees on Head and Neck Cancer alongside delivering a study day for Dental Core Trainees on Effective Poster Design.

Professional activities and memberships

Oral and Maxillofacial Pathology Representative for the Speciality Advisory Committee for the Additional Dental Specialties (SACADS) (November 2022 to present)
Junior Doctor Forum (JDF) Representative at Sheffield Teaching Hospitals (July 2022 to present)
Member of the British Society for Oral and Maxillofacial Pathology (BSOMP)
Member of The Pathological Society of Great Britain and Ireland
Member of the European Society of Pathology (ESP)
Member of British Association for Cancer Research (BACR)
Reviewer for npj Precision Oncology, Oral Surgery, BMJ case reports and Frontiers of Oral and Maxillofacial Medicine.

Clinical: Dr Crane is undertaking clinical academic specialist training in Oral and Maxillofacial Pathology, routinely completing macroscopic dissection and reporting of specimens from the head and neck under the supervision of consultant colleagues. She is involved in the teaching of dental core trainees and junior registrars within the department.