- Researchers from the University of Sheffield and the University of Birmingham have joined forces with NLC Health Ventures to co-found a company to develop therapeutics for stroke and spinal cord injury.
- Midlands Pharmaceuticals will develop MLP-1236, an inhibitor of two enzymes associated with inflammation caused by injury to the central nervous system.
- Around 12 million people suffer a stroke and over 1.2 million people suffer a spinal cord injury each year worldwide, with current treatments only offering modest relief.
Researchers from the University of Sheffield and the University of Birmingham have joined forces with NLC Health Ventures to co-found a company that will focus on the clinical development of a new therapeutic for spinal cord injury and cerebrovascular disease, including stroke.
Announced today by NLC Health Ventures, the launch of Midland Pharmaceuticals Ltd will see Arshad Majid, Deputy Dean and the Head of Neurosciences at the University of Sheffield’s School of Medicine and Population Health, and Professors Zubair Ahmed, from Birmingham’s Institute of Inflammation and Ageing, join veteran CEO Dr Peter D. Suzdak, who has an established track record in leading companies to clinical stage and bringing novel therapeutics to market.
Midland Pharmaceuticals will focus on the clinical development of MLP-1236, a first in class dual inhibitor of MMP-9 and MMP-12, two enzymes that are critical in the inflammatory process following injury to the central nervous system.
MLP-1236 has already completed Phase 1 and Phase 2a clinical studies and was shown to be safe and well tolerated. In preclinical models, MLP-1236 was effective in reversing the major pathologies associated with spinal cord injury (oedema, blood spinal cord barrier breakdown, scar tissue formation, proinflammatory cytokine release, neuropathic pain and sensory function deficits). In multiple preclinical stroke models, MLP-1236 reduced brain tissue death and injury and resulted in significantly improved functional outcomes.
Following the completion of an ongoing financing, Midland Pharmaceuticals will initiate a Phase 2b clinical proof-of-principle trial of MLP-1236 in patients with spinal cord injury. An additional Phase 2b trial in stroke is also being planned.
The co-founding researchers are both highly experienced in drug discovery and clinical development. Professor Ahmed’s research on molecular mechanisms underpinning repair and regeneration in the central nervous system has received wide acclaim, and Professor Majid is a world leading stroke neurologist and translational neuroscientist with extensive experience in preclinical and clinical research.
Spinal cord injury and stroke are devastating medical conditions resulting in permanent disability and death. Annually, there are more than 1.2 million new cases of spinal cord injury and approximately 12 million people who suffer a stroke each year worldwide. Current treatments offer modest benefit or only symptomatic relief, underlining the need for new, more effective therapeutic interventions.
Professor Arshad Majid, Deputy Dean and the Head of Neurosciences at The University of Sheffield said: "I am thrilled to join Midland Pharmaceuticals in our mission to combat stroke, a devastating neurological disease that impacts countless lives. Current treatments offer limited relief, but our preclinical studies of MLP-1236 have shown exceptional safety and efficacy in significantly reducing stroke-induced brain damage and disability in animal models. Additionally, the University of Birmingham has observed similar benefits in models of spinal cord injury. We are excited to advance MLP-1236 into clinical trials, marking a significant step forward in developing this promising compound."
Dr Peter D Suzdak, PhD, CEO of Midland Pharmaceuticals said: “The loss of sensory and motor function that occurs following spinal cord injury and stroke represents a major unmet medical need. Current therapies offer only modest symptomatic benefits to these patients but do not treat the underlying neuronal damage that occurs. Inhibition of MMP-9 and -12 with MLP-1236 has the possibility of transforming the way these patients are treated.”