Professor Syed Hussain
MBBS, MSc, MD, FRCP
Clinical Medicine, School of Medicine and Population Health
Professor of Medical Oncology
+44 114 215 9682
Full contact details
Clinical Medicine, School of Medicine and Population Health
Room 228, 2nd Floor, Broomcross Building
Weston Park Hospital
Whitham Road
Sheffield
S10 2SJ
- Profile
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For enquiries please contact - ClinMed-Operational@sheffield.ac.uk
Professor Hussain graduated from Dow Medical College Karachi in 1994. He completed his general medical professional training in UK. He did his Doctorate in Oncology from University of Birmingham. He completed his medical oncology training in Birmingham, United Kingdom and received his certification and specialist registration in medical oncology.
Professor Hussain is Professor and Honorary Consultant in Medical Oncology at the University of Sheffield and Sheffield Teaching Hospitals NHS Trust. His major areas of interest are management of urological cancers, clinical trials, early drug development and translational medicine. He has set up several clinical trials from early phase to late phase studies during his career. His work on organ preservation in bladder cancer moved all the way from an early phase I study (Hussain et al Annals of Oncology 2001) to phase II efficacy study (Hussain et al BJC 2004) that led to a Cancer Research UK funded study BC2001 trial that was reported in New England Journal of Medicine (James, Hussain, Hall et al April 2012). This study has now changed the standard of care for patients with muscle invasive bladder cancer opting for organ preservation treatment globally. He has tailored split dose cisplatin regimen that has led to expand the spectrum of patients receiving cisplatin-based chemotherapy in bladder cancer (Hussain et al BJC 2004). He is a principal investigator of several studies in urological cancers. He was chief investigator of a national randomised placebo-controlled phase II neo-adjuvant study (NEOBLADE) in muscle invasive bladder cancer. He has served as a chief investigator of various early phase clinical trials, and translational studies. He is a chief investigator of a first in human window of opportunity study (INVEST) investigating the role of intravesical/intratumoral atezolizumab in patients with bladder cancer undergoing curative cystectomy. This is sponsored by STH and funded by Roche. He is also chief investigator of an international window of opportunity trial SOGUG NEOWIN investigating the role of erdafitinib and cetrelimab in FGF mutant bladder cancer patients undergoing curative cystectomy. This is jointly led by Hussain (UK), with Andrea Necchi (Italy), Yohann Loriot (France) and Guillermo Velasco (Spain) as other co-chief investigators. This study is funded by Janssen. He has authored over 125 peer-reviewed publications including 4 book chapters in textbooks of oncology. His Google scholar H-index is 40 with over 9800 citations (April 2023). He has published in high impact journals including New England Journal of Medicine, Lancet, Lancet Oncology, JAMA, JAMA Oncology, Journal of Clinical Oncology, European Urology, Annals of Oncology, Nature Communications, Clinical Cancer Research, British Journal of Cancer. He has been an invited speaker to number of national and international meetings and have delivered over 110 invited lectures. He has secured funding from cancer charities, national funding bodies and industries of over £15 million.
Professor Hussain was the member of NCRI Bladder and Renal group and Chair of the NCRI- Advanced Bladder Cancer sub-group in his national role. Professor Hussain was the expert witness to NICE on successful technology appraisals of Atezolizumab (2017), Avelumab (2021) and Nivolumab in Bladder cancer (2022).
- Research interests
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My major areas of interest are management of urological cancers, clinical trials, early drug development and translational medicine. I have set up a large number of clinical trials from early phase to late phase studies during my career.
My work on organ preservation in bladder cancer moved all the way from an early phase I study (Hussain et al Annals of Oncology 2001), to phase II efficacy study (Hussain et al BJC 2004) that led to a Cancer Research UK funded study BC2001 trial that was reported in New England Journal of Medicine (James, Hussain, Hall et al April 2012).
This study has now changed the standard of care for patients with muscle invasive bladder cancer opting for organ preservation treatment. I am principal investigator of a number of studies in urological cancers.
I am chief investigator of a national randomised placebo-controlled phase II neo-adjuvant study in muscle invasive bladder cancer and have served as chief investigator of various early phase trials, and translational studies.
I have authored over 125 peer-reviewed publications including 4 book chapters in textbooks of oncology. My Google scholar H-index is 40 with over 9800 citations (April 2023). I have published in high impact journals including New England Journal of Medicine, Lancet, Lancet Oncology, JAMA, JAMA Oncology, Journal of Clinical Oncology, European Urology, Annals of Oncology, Nature Communications, Clinical Cancer Research, British Journal of Cancer. I have been an invited speaker at a number of national and international meetings and have delivered over 110 invited lectures. I have secured funding from cancer charities, national funding bodies and industries of over £15 million.
Current Projects
- Setting up of clinical trials in bladder cancers.
- Early phase studies in bladder cancer.
- Development of panel of Biomarkers in bladder cancer.
- Translational research linked to bladder cancer clinical trials.
- Publications
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Featured publications
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Journal articles
- Real-word outcomes for high-risk non-muscle-invasive bladder cancer: screened patients for the BRAVO trial. BJU International. View this article in WRRO
- 2020TiP SOGUG-NEOWIN: A phase II, open-label, multi-centre trial evaluating the efficacy and safety of erdafitinib (ERDA) monotherapy and ERDA and cetrelimab (CET) as neoadjuvant treatment in cisplatin-ineligible patients with muscle-invasive bladder cancer (MIBC) and FGFR gene alterations. Annals of Oncology, 35, S1163-S1164.
- Eligibility Criteria for Different Platinum-Based Chemotherapy Regimens in Metastatic Urothelial Carcinoma. Cureus, 16(8), e66520.
- Biomarkers associated with survival in patients with platinum-refractory urothelial carcinoma treated with paclitaxel. Urologic Oncology: Seminars and Original Investigations.
- Use of gene expression patterns to identify unique molecular subtypes in muscle invasive bladder cancer: GUSTO.. Journal of Clinical Oncology, 42(16_suppl), TPS4621-TPS4621.
- SOGUG-NEOWIN: A phase 2, open-label, multi-centre, multi-national interventional trial evaluating the efficacy and safety of erdafitinib (ERDA) monotherapy and ERDA and cetrelimab (CET) as neoadjuvant treatment in patients with cisplatin-ineligible muscle-invasive bladder cancer (MIBC) whose tumours express FGFR gene alterations.. Journal of Clinical Oncology, 42(16_suppl), TPS4623-TPS4623.
- Stratified absolute benefit with adjuvant immunotherapy (aIO) in muscle-invasive bladder cancer (MIBC): A meta-analysis.. Journal of Clinical Oncology, 42(16_suppl), e16619-e16619.
- Cost-effectiveness analysis of contemporary first-line (1L) agents in locally advanced/metastatic urothelial carcinoma (la/mUC).. Journal of Clinical Oncology, 42(16_suppl), 4591-4591.
- UPDATED EFFICACY AND SAFETY OF ORAL ERDAFITINIB IN PATIENTS WITH BACILLUS CALMETTE-GUÉRIN–UNRESPONSIVE, HIGH-RISK NON-MUSCLE–INVASIVE BLADDER CANCER WITH FGFR3/2 ALTERATIONS IN THOR-2 COHORT 2. Urologic Oncology: Seminars and Original Investigations, 42, S53-S53.
- MARKER LESION STUDY OF ORAL ERDAFITINIB IN PATIENTS WITH INTERMEDIATE-RISK NON-MUSCLE–INVASIVE BLADDER CANCER WITH FGFR3/2 ALTERATIONS IN THOR-2: UPDATED COHORT 3 RESULTS. Urologic Oncology: Seminars and Original Investigations, 42, S58-S58.
- SOGUG-NEOWIN: A Phase 2, open-label, multi-centre, multi-national interventional trial evaluating the efficacy and safety of Erdafitinib (ERDA) monotherapy and ERDA and Cetrelimab (CET) as neoadjuvant treatment in cisplatin-ineligible patients with Muscle-Invasive Bladder Cancer (MIBC) whose tumours express FGFR gene alterations. European Urology, 85, S427-S427.
- A hypoxia biomarker does not predict benefit from giving chemotherapy with radiotherapy in the BC2001 randomised controlled trial. eBioMedicine, 101, 105032-105032.
- Real world outcomes for maintenance avelumab treatment in locally advanced/metastatic urothelial cancer after platinum-based chemotherapy.. Journal of Clinical Oncology, 42(4_suppl), 584-584.
- INVEST: A phase Ib window of opportunity study of atezolizumab administered either intravesically or direct tumour injection in patients with bladder cancer prior to radical cystectomy.. Journal of Clinical Oncology, 42(4_suppl), tps710-tps710.
- Thromboembolic events associated with neoadjuvant chemotherapy for muscle invasive cancer of the bladder.. Journal of Clinical Oncology, 42(4_suppl), 586-586.
- Verification of molecular subtyping of bladder cancer in the GUSTO clinical trial. The Journal of Pathology: Clinical Research, 10(2). View this article in WRRO
- Erdafitinib in BCG-treated high-risk non-muscle-invasive bladder cancer. Annals of Oncology, 35(1), 98-106.
- 2363MO A phase II study investigating the safety and efficacy of neoadjuvant atezolizumab in non-urothelial, muscle invasive bladder cancer (ABACUS-2). Annals of Oncology, 34, S1201-S1202.
- LBA102 THOR-2 cohort 1: Results of erdafitinib (ERDA) vs intravesical chemotherapy (chemo) in patients (pts) with high-risk non–muscle-invasive bladder cancer (HR NMIBC) with select fibroblast growth factor receptor alterations (FGFRALT) who received prior bacillus calmette-guérin (BCG) treatment. Annals of Oncology, 34, S1341-S1342.
- 2408TiP DISCUS: A randomised phase II study of 3 vs 6 cycles of chemotherapy followed by maintenance avelumab in advanced urothelial cancer - Wearable devices and circulating biomarkers assessing quality of life and surrogate efficacy endpoints. Annals of Oncology, 34, S1224-S1225.
- The role of volume of disease for treatment selection in patients with metastatic castration sensitive prostate cancer (mCSPC): A living meta-analysis.. Journal of Clinical Oncology, 41(16_suppl), 5088-5088.
- Checkpoint Inhibitors in Urothelial Carcinoma—Future Directions and Biomarker Selection. European Urology.
- Abstract CT119: A first-in-human phase 1 study of LOXO-435, a potent, highly isoform-selective FGFR3 inhibitor in advanced solid tumors with FGFR3 alterations (trial in progress). Cancer Research, 83(8_Supplement), CT119-CT119.
- PD36-12 MEASURING OBJECTIVE RECOVERY OF ACTIVITY LEVELS USING WEARABLE DEVICES FOLLOWING OPEN VS INTRACORPOREAL ROBOTIC CYSTECTOMY: SECONDARY OUTCOMES ANALYSIS OF THE IROC RANDOMIZED TRIAL. Journal of Urology, 209(Supplement 4).
- Pathologic response with neoadjuvant chemotherapy, immunotherapy, and chemo-immunotherapy for muscle-invasive bladder cancer (MIBC): A systematic review and meta-analysis.. Journal of Clinical Oncology, 41(6_suppl), 531-531.
- A living interactive systematic review and network meta-analysis evaluating systemic therapies in metastatic castration-sensitive prostate cancer (mCSPC).. Journal of Clinical Oncology, 41(6_suppl), 193-193.
- Phase 2 study of the efficacy and safety of erdafitinib in patients (pts) with intermediate-risk non–muscle-invasive bladder cancer (IR-NMIBC) with FGFR3/2 alterations (alt) in THOR-2: Cohort 3 interim analysis.. Journal of Clinical Oncology, 41(6_suppl), 504-504.
- Comparing objective recovery of activity levels using wearable devices in open vs. intracorporeal robotic cystectomy: An analysis of the secondary outcomes of the iROC randomized trial. European Urology, 83, S219-S220.
- Diagnosis, treatment and survival from bladder, upper urinary tract and urethral cancers: Real world findings from NHS England between 2013 and 2019. BJU International.
- Re: Predictive Biomarkers for Survival Benefit With Ramucirumab in Urothelial Cancer in the RANGE Trial Editorial Comment. JOURNAL OF UROLOGY, 209(1), 291-291.
- A randomized, double-blind, biomarker-selected, phase II clinical trial of maintenance poly ADP-ribose polymerase inhibition with rucaparib following chemotherapy for metastatic urothelial carcinoma. Journal of Clinical Oncology, 41(1), 54-64.
- Hyperthermic intravesical chemotherapy with mitomycin‐C for the treatment of high‐risk non‐muscle‐invasive bladder cancer patients. BJUI Compass. View this article in WRRO
- 1772P Characterisation of a DNA repair deficiency (DRD) biomarker phenotype in metastatic urothelial carcinoma (mUC) within the ATLANTIS clinical trial platform. Annals of Oncology, 33, S1348-S1348.
- 1417P Mixed treatment comparisons evaluating contemporary therapies in metastatic castration sensitive prostate cancer (mCSPC): A living systematic review. Annals of Oncology, 33, S1193-S1193.
- 1734MO Hypoxic bladder cancers have a poorer outcome following hypofractionated vs conventionally fractionated radiotherapy in the BC2001 and BCON randomised trials. Annals of Oncology, 33, S1330-S1330.
- A randomised, double blind, phase II clinical trial of maintenance cabozantinib following chemotherapy for metastatic urothelial carcinoma (mUC): Final analysis of the ATLANTIS cabozantinib comparison.. Journal of Clinical Oncology, 40(17_suppl), lba4505-lba4505.
- COMPARISON BETWEEN A NOVEL 0.025-INCH AND STANDARD 0.035-INCH GUIDEWIRE IN WIRE- GUIDED ERCP CANNULATION: INTERIM RESULTS OF A PROSPECTIVE, RANDOMIZED TRIAL. Gastrointestinal Endoscopy, 95(6), AB287-AB287.
- Quantifying the absolute benefit of neoadjuvant chemotherapy followed by definitive therapy in patients with muscle-invasive bladder cancer: A systematic review and meta-analysis.. Journal of Clinical Oncology, 40(16_suppl), 4594-4594.
- Case of the month from the University of Sheffield, UK : expediting definitive treatment in patients with invasive bladder cancer : an MRI-guided pathway. BJU International, 129(6), 691-694. View this article in WRRO
- Effect of robot-assisted radical cystectomy with intracorporeal urinary diversion vs open radical cystectomy on 90-day morbidity and mortality among patients with bladder cancer : a randomized clinical trial. JAMA. View this article in WRRO
- Disparities in Representation of Women, Older Adults and Racial/Ethnic Minorities in Immune Checkpoint Inhibitor Trials.. Am J Med.
- A Phase 2 Study of S-588410 Maintenance Monotherapy for Platinum-Treated Advanced or Metastatic Urothelial Carcinoma. Bladder Cancer, 1-14.
- Addition of nintedanib or placebo to neoadjuvant gemcitabine and cisplatin in locally advanced muscle-invasive bladder cancer (NEOBLADE) : a double-blind, randomised, phase 2 trial. The Lancet Oncology, 23(5), 650-658.
- Predictive biomarkers for survival benefit with ramucirumab in urothelial cancer in the RANGE trial. Nature Communications, 13.
- Efficacy and Safety of Autologous Dendritic Cell–Based Immunotherapy, Docetaxel, and Prednisone vs Placebo in Patients With Metastatic Castration-Resistant Prostate Cancer. JAMA Oncology, 8(4), 546-546.
- A quantitative synthesis of disparities in the inclusion of racial/ethnic minorities and older adults in prostate cancer clinical trials over the last three decades.. Journal of Clinical Oncology, 40(6_suppl), 26-26.
- A systematic review and network meta-analysis evaluating neoadjuvant treatments in muscle-invasive bladder cancer.. Journal of Clinical Oncology, 40(6_suppl), 518-518.
- A randomized, double blind, biomarker selected, phase II clinical trial of maintenance PARP inhibition following chemotherapy for metastatic urothelial carcinoma (mUC): Final analysis of the ATLANTIS rucaparib arm.. Journal of Clinical Oncology, 40(6_suppl), 436-436.
- First-line treatment options in metastatic castration-sensitive prostate cancer: A systematic review and network meta-analysis.. Journal of Clinical Oncology, 40(6_suppl), 132-132.
- Real-world evidence from a single U.K. cancer center for atezolizumab in second-line setting in advanced urothelial cancer: Moving beyond clinical trials.. Journal of Clinical Oncology, 40(6_suppl), 461-461.
- Robot assisted radical cystectomy with intracorporeal urinary diversion versus open radical cystectomy: Results from the iROC prospective randomised controlled trial. European Urology, 81, S1125-S1125.
- Chemoradiotherapy in Muscle-invasive Bladder Cancer: 10-yr Follow-up of the Phase 3 Randomised Controlled BC2001 Trial. European Urology.
- Rare case of chemotherapy-refractory metastatic vaginal squamous cell carcinoma with complete response to concurrent pembrolizumab and radiotherapy- case report and literature review. Gynecologic Oncology Reports, 38. View this article in WRRO
- S2563 Bacteremia From ERCP? A Rare Case of Streptococcus salivarius Bacteremia After ERCP Without Oral Lesion. The American Journal of Gastroenterology, 116(1), s1079-s1080.
- S2355 An Unusual Presentation of a Rare Cause of Lower Gastrointestinal Bleeding: Cecal Dieulafoy’s Lesion Presenting as Melena. The American Journal of Gastroenterology, 116(1), s1002-s1002.
- S2372 Hemostatic Powder and Over-the-Scope Clip for Duodenal Variceal Bleeding. The American Journal of Gastroenterology, 116(1), s1008-s1008.
- Concurrent use of nivolumab and radiotherapy for patients with metastatic non‑small cell lung cancer and renal cell carcinoma with oligometastatic disease progression on nivolumab. Molecular and Clinical Oncology, 15(4).
- The Scottish Bladder Cancer Quality Performance Indicators Influencing Outcomes, Prognosis, and Surveillance (Scot BC Quality OPS) Clinical Project. European Urology Focus.
- Pembrolizumab alone or combined with chemotherapy versus chemotherapy as first-line therapy for advanced urothelial carcinoma (KEYNOTE-361): a randomised, open-label, phase 3 trial. The Lancet Oncology, 22(7), 931-945.
- Reply to Santhanam Sundar and Paul Symonds' Letter to the Editor re: Syed A. Hussain, Nuria Porta, Emma Hall, et al. Outcomes in Patients with Muscle-invasive Bladder Cancer Treated with Neoadjuvant Chemotherapy Followed by (Chemo)radiotherapy in the BC2001 Trial. Eur Urol 2021;79:307-15.. Eur Urol.
- Impact of COVID 19 pandemic on psychological wellbeing of oncology clinicians in MENA (Middle East and North Africa) region.. Journal of Clinical Oncology, 39(15_suppl), e24105-e24105.
- Disparities in reporting and representation of women, older adults and racial minorities in immune checkpoint inhibitor (ICI) clinical trials.. Journal of Clinical Oncology, 39(15_suppl), 6549-6549.
- Clinical Outcomes of Platinum-ineligible Patients with Advanced Urothelial Carcinoma Treated With First-line PD1/L1 Inhibitors. Clinical Genitourinary Cancer.
- A Living, Interactive Systematic Review and Network Meta-analysis of First-line Treatment of Metastatic Renal Cell Carcinoma. European Urology.
- Phase II open-label study of S-588410 as maintenance monotherapy after first-line platinum-containing chemotherapy in patients with advanced or metastatic urothelial carcinoma.. Journal of Clinical Oncology, 39(6_suppl), 440-440.
- Quality of Life After Bladder Cancer: A Cross-sectional Survey of Patient-reported Outcomes. European Urology.
- Urological cancer patients receiving treatment during COVID-19 : a single-centre perspective. British Journal of Cancer.
- Outcomes in Patients with Muscle-invasive Bladder Cancer Treated with Neoadjuvant Chemotherapy Followed by (Chemo)radiotherapy in the BC2001 Trial. European Urology, 79(2), 307-315.
- Durvalumab alone and durvalumab plus tremelimumab versus chemotherapy in previously untreated patients with unresectable, locally advanced or metastatic urothelial carcinoma (DANUBE): a randomised, open-label, multicentre, phase 3 trial. The Lancet Oncology, 21(12), 1574-1588.
- Perioperative Treatment in Muscle-invasive Bladder Cancer: Analysis of Secondary Endpoints in a Randomized Trial Comparing Gemcitabine and Cisplatin Versus Dose-dense Methotrexate, Vinblastine, Adriamycin, and Cisplatin. European Urology.
- Occupational Bladder cancer: A cross section survey of previous employments, tasks and exposures matched to cancer phenotypes. PLoS ONE.
- Incidence, Patterns, and Outcomes with Adjuvant Chemotherapy for Residual Disease After Neoadjuvant Chemotherapy in Muscle-invasive Urinary Tract Cancers. European Urology Oncology, 3(5), 671-679.
- S3088 Single Center Evaluation of Patient and Healthcare System Related Factors Influencing Inadequate Bowel Preparation Rates. The American Journal of Gastroenterology, 115(1), s1628-s1628.
- S2821 Ileocolonic Intussusception Associated Large B-Cell Lymphoma. The American Journal of Gastroenterology, 115(1), s1475-s1475.
- S2339 Novel Approach to Endoscopic Foreign Body Retrieval From the Gastric Body. The American Journal of Gastroenterology, 115(1), s1240-s1240.
- S0601 Risk of Bleeding Following Percutaneous Endoscopic Gastrostomy in Patients on Dual Antiplatelet Therapy. The American Journal of Gastroenterology, 115(1), s300-s300.
- Survey of the impact of COVID-19 on oncologists’ decision making in cancer. Jco Global Oncology, 6, 1248-1257.
- Correction: Inhibitor SBFI26 suppresses the malignant progression of castration-resistant PC3-M cells by competitively binding to oncogenic FABP5.. Oncotarget, 11(31), 3025-3025.
- The Impact of Centralised Services on Metric Reflecting High-quality Performance: Outcomes from 1110 Consecutive Radical Cystectomies at a Single Centre. European Urology Focus.
- ATLANTIS: a randomised multi-arm phase II biomarker-directed umbrella screening trial of maintenance targeted therapy after chemotherapy in patients with advanced or metastatic urothelial cancer. Trials, 21.
- Reply to Wei Liu, Xiaoping Liu, Sheng Li’s Letter to the Editor, re: Robert A. Huddart, Emma Hall, Rebecca Lewis, et al. Patient-reported Quality of Life Outcomes in Patients Treated for Muscle-invasive Bladder Cancer with Radiotherapy ± Chemotherapy in the BC2001 Phase III Randomised Controlled Trial. Eur Urol 2020;77:260–8. European Urology, 77(6), e156-e157.
- Phase II randomized placebo-controlled neoadjuvant trial of nintedanib or placebo with gemcitabine and cisplatin in locally advanced muscle invasive bladder cancer (NEO-BLADE).. Journal of Clinical Oncology, 38(6_suppl), 438-438.
- A phase I/II feasibility study of cetuximab with 5FU and mitomycin C or cisplatin with concurrent radiotherapy in muscle invasive bladder cancer.. Journal of Clinical Oncology, 38(6_suppl), 491-491.
- Outcomes of advanced plasmacytoid urothelial carcinoma receiving systemic therapy.. Journal of Clinical Oncology, 38(6_suppl), 580-580.
- Patient reported quality of life outcomes in patients treated for muscle invasive bladder cancer with radiotherapy +/- chemotherapy in the BC2001 phase III randomised controlled trial. European Urology, 77(2), 260-268.
- CD40L membrane retention enhances the immunostimulatory effects of CD40 ligation. Scientific Reports, 10(1). View this article in WRRO
- Ramucirumab plus docetaxel versus placebo plus docetaxel in patients with locally advanced or metastatic urothelial carcinoma after platinum-based therapy (RANGE): overall survival and updated results of a randomised, double-blind, phase 3 trial. The Lancet Oncology, 21(1), 105-120.
- Biomarker analyses of ramucirumab in patients with platinum refractory urothelial cancer from RANGE, a global, randomized, double-blind, phase III study. Annals of Oncology, 30, v373-v374.
- 2339 Hemobilia-Associated Acute Cholecystitis Post-Percutaneous Liver Biopsy: A Unexpected Sequelae of a Known Complication. The American Journal of Gastroenterology, 114(1), s1304-s1304.
- 545 Converting Inpatient Consults to Directly Scheduled Outpatient Procedures. American Journal of Gastroenterology, 114(1), S315-S315.
- Effects of indoor particulate matter exposure on daily asthma control. Annals of Allergy, Asthma & Immunology, 123(4), 375-380.e3.
- Mutation Analysis of the FGFR3-encoding gene Does Not Predict Response to Checkpoint Inhibitor Treatment in Metastatic Bladder Cancer. European Urology, 76(5), 604-606.
- Safe Use of Immune Checkpoint Inhibitors in the Multidisciplinary Management of Urological Cancer: The European Association of Urology Position in 2019. European Urology, 76(3), 368-380.
- Vinflunine in the treatment of relapsed metastatic urothelial cancer: A systematic review and meta-analysis of real-world series. Critical Reviews in Oncology and Hematology. View this article in WRRO
- Targeting IGF-1/2 with xentuzumab (Xe) plus enzalutamide (En) in metastatic castration-resistant prostate cancer (mCRPC) after progression on docetaxel chemotherapy (DCt) and abiraterone (Abi): Randomized phase II trial results.. Journal of Clinical Oncology, 37(15_suppl), 5030-5030.
- First-line PD(L)1 inhibitors for platinum-ineligible advanced urothelial carcinoma (aUC).. Journal of Clinical Oncology, 37(15_suppl), e16024-e16024.
- Erdafitinib in high-risk patients (pts) with advanced urothelial carcinoma (UC).. Journal of Clinical Oncology, 37(15_suppl), 4543-4543.
- Mo1645 – The Fecal Occult Blood Test Positive Consult: Inpatient Versus Outpatient Evaluation. Gastroenterology, 156(6), s-814-s-815.
- Corrigendum re: “Atezolizumab in Platinum-treated Locally Advanced or Metastatic Urothelial Carcinoma: Outcomes by Prior Number of Regimens” [Eur Urol 2018;73:462–8]. European Urology, 75(3), e82-e83.
- First-line PD1/PD-L1 inhibitors for platinum-ineligible advanced urothelial carcinoma (UC).. Journal of Clinical Oncology, 37(7_suppl), 432-432.
- Pharmacodynamic and Clinical Results from a Phase I/II Study of the HSP90 Inhibitor Onalespib in Combination with Abiraterone Acetate in Prostate Cancer. Clinical Cancer Research, 25(15), 4624-4633.
- 865PDRANGE, a phase III, randomized, placebo-controlled, double-blind trial of ramucirumab (RAM) and docetaxel (DOC) in platinum-refractory urothelial carcinoma (UC): Overall survival results. Annals of Oncology, 29(suppl_8), viii304-viii305.
- Quantification of Hemostatic Clip Usage in Treating Non-Variceal Gastrointestinal Bleeding. The American Journal of Gastroenterology, 113(Supplement), s1553.
- Technical and Clinical Outcomes of Colonic Stent Placement in Patients With Proximal Malignant Large Bowel Obstruction. The American Journal of Gastroenterology, 113(Supplement), s96.
- From Clinical Trials to Real-life Clinical Practice: The Role of Immunotherapy with PD-1/PD-L1 Inhibitors in Advanced Urothelial Carcinoma. European Urology Oncology, 1(6), 486-500.
- Su1710 ENDOSCOPIC MANAGEMENT OF MALIGNANT LARGE BOWEL OBSTRUCTION: A SINGLE-CENTER, COMMUNITY-BASED STUDY. Gastrointestinal Endoscopy, 87(6), ab381.
- Concurrent nivolumab and radiotherapy to improve outcomes for patients with metastatic lung and renal cancers.. Journal of Clinical Oncology, 36(15_suppl), e15078-e15078.
- Sa1423 - Tokyo Guidelines Fail to Predict Patients with Severe Purulent Cholangitis. Gastroenterology, 154(6), s-300-s-301.
- Atezolizumab in Platinum-treated Locally Advanced or Metastatic Urothelial Carcinoma: Outcomes by Prior Number of Regimens. European Urology, 73(3), 462-468.
- Real-world (RW) evidence of vinflunine in metastatic urothelial cancer (mUC): A systematic review of seven European studies.. Journal of Clinical Oncology, 36(6_suppl), 463-463.
- Atezolizumab versus chemotherapy in patients with platinum-treated locally advanced or metastatic urothelial carcinoma (IMvigor211): a multicentre, open-label, phase 3 randomised controlled trial. The Lancet, 391(10122), 748-757.
- Venous Thromboembolism Risk in Patients With Locoregional Urothelial Tract Tumors. Clinical Genitourinary Cancer, 16(1), e161-e167.
- Robot-assisted Versus Open Radical Cystectomy in Patients Receiving Perioperative Chemotherapy for Muscle-invasive Bladder Cancer: The Oncologist’s Perspective from a Multicentre Study. European Urology Focus, 4(6), 937-945.
- Ramucirumab plus docetaxel versus placebo plus docetaxel in patients with locally advanced or metastatic urothelial carcinoma after platinum-based therapy (RANGE): a randomised, double-blind, phase 3 trial. The Lancet, 390(10109), 2266-2277.
- LBA4_PR RANGE: A randomized, double-blind, placebo-controlled phase 3 study of docetaxel (DOC) with or without ramucirumab (RAM) in platinum-refractory advanced or metastatic urothelial carcinoma. Annals of Oncology, 28, v621.
- Randomized Phase II Study Investigating Pazopanib Versus Weekly Paclitaxel in Relapsed or Progressive Urothelial Cancer. Journal of Clinical Oncology, 35(16), 1770-1777.
- Tu1498 Fully Covered Metal Stents May Be More Effective Than Plastic Stents in Treating Post-Cholecystectomy Bile Leaks. Gastrointestinal Endoscopy, 85(5), ab645.
- Towards better models and mechanistic biomarkers for drug-induced gastrointestinal injury. Pharmacology & Therapeutics, 172, 181-194.
- Inhibitor SBFI26 suppresses the malignant progression of castration-resistant PC3-M cells by competitively binding to oncogenic FABP5. OncoTargets and Therapy, 8(19), 31041-31056. View this article in WRRO
- Gene expression profiling in bladder cancer identifies potential therapeutic targets. International journal of oncology, 50(4), 1147-1159.
- BC2001 long-term outcomes: A phase III randomized trial of chemoradiotherapy versus radiotherapy (RT) alone and standard RT versus reduced high-dose volume RT in muscle-invasive bladder cancer.. Journal of Clinical Oncology, 35(6_suppl), 280-280.
- Thrombo-embolic events (TEE) during neoadjuvant chemotherapy for muscle invasive bladder cancer.. Journal of Clinical Oncology, 35(6_suppl), 339-339.
- Atezolizumab (atezo) in platinum-treated locally advanced or metastatic urothelial carcinoma (mUC): Outcomes by prior therapy.. Journal of Clinical Oncology, 35(6_suppl), 323-323.
- Association of changes in circulating cell-free plasma DNA (cfDNA) and circulating tumor cells (CTC) during treatment with clinical outcome from olaparib in castration-resistant prostate cancer (CRPC): Exploratory analyses from the TOPARP-A trial.. Journal of Clinical Oncology, 35(6_suppl), 141-141.
- 2115 Quality of life (QL) of muscle invasive bladder cancer (MIBC) patients (pts) receiving radiotherapy (RT) +/- chemotherapy (CT) in the BC2001 trial (CRUK/01/004). European Journal of Cancer, 72, s186-s187.
- The predictive and prognostic value of tumour necrosis in muscle invasive bladder cancer patients receiving radiotherapy with or without chemotherapy in the BC2001 trial (CRUK/01/004). British Journal of Cancer, 116(5), 649-657.
- VICTOR: Vinflunine in advanced metastatic transitional cell carcinoma of the urothelium: A retrospective analysis of the use of vinflunine in multi-centre real life setting as second line chemotherapy through Free of Charge Programme for patients in the UK and Ireland. International journal of oncology, 50(3), 768-772.
- A phase II/III, double -blind, randomised trial comparing maintenance lapatinib versus placebo after first line chemotherapy in HER1/2 positive metastatic cancer patients.. Journal of Clinical Oncology, 35(1), 48-55.
- The increased expression of fatty acid-binding protein 9 in prostate cancer and its prognostic significance. Oncotarget, 7(50), 82783-82797. View this article in WRRO
- IMvigor210: updated analyses of first-line (1L) atezolizumab (atezo) in cisplatin (cis)-ineligible locally advanced/metastatic urothelial carcinoma (mUC). Annals of Oncology, 27, vi270-vi270.
- 783P Atezolizumab (atezo) in platinum (plat)-treated locally advanced/metastatic urothelial carcinoma (mUC): Updated OS, safety and biomarkers from the Ph II IMvigor210 study. Annals of Oncology, 27, vi270.
- Phase III Study of Cabozantinib in Previously Treated Metastatic Castration-Resistant Prostate Cancer: COMET-1. Journal of Clinical Oncology, 34(25), 3005-3013.
- Cisplatin- Versus Non–Cisplatin-based First-Line Chemotherapy for Advanced Urothelial Carcinoma Previously Treated With Perioperative Cisplatin. Clinical Genitourinary Cancer, 14(4), 331-340.
- Cost-effectiveness of zoledronic acid and strontium-89 as bone protecting treatments in addition to chemotherapy in patients with metastatic castrate-refractory prostate cancer: results from the TRAPEZE trial (ISRCTN 12808747). BJU International. View this article in WRRO
- FIESTA: A phase Ib and pharmacokinetic trial of AZD4547 in combination with gemcitabine and cisplatin.. Journal of Clinical Oncology, 34(15_suppl), 4521-4521.
- Management of non metastatic castrate resistant prostate cancer (NM-CRPC), results of a UK wide national survey.. Journal of Clinical Oncology, 34(15_suppl), e16520-e16520.
- PARP Inhibition in Prostate Cancer: A Promising Approach. Oncology, 30(5), 393-394.
- Clinical Outcomes and Survival Following Treatment of Metastatic Castrate-Refractory Prostate Cancer With Docetaxel Alone or With Strontium-89, Zoledronic Acid, or Both. JAMA Oncology, 2(4), 493-493. View this article in WRRO
- PD27-12 PRIMARY ANALYSIS OF IMVIGOR 210: ATEZOLIZUMAB IN PLATINUM-TREATED ADVANCED UROTHELIAL CARCINOMA. Investigative Urology, 195(4), e654.
- Bladder Sparing Approaches for Muscle-Invasive Bladder Cancers. Current Treatment Options in Oncology, 17(3).
- A Randomised Phase 2 Study of AZD2014 Versus Everolimus in Patients with VEGF-Refractory Metastatic Clear Cell Renal Cancer. European Urology, 69(3), 450-456.
- Fatty acid activated PPARγ promotes tumorigenicity of prostate cancer cells by up regulating VEGF via PPAR responsive elements of the promoter. Oncotarget, 7(8), 9322-9339.
- PLUTO: A randomised phase II study of pazopanib versus paclitaxel in relapsed urothelial tumours.. Journal of Clinical Oncology, 34(2_suppl), 430-430.
- Outcome of radical cystectomy series in the management of muscle invasive bladder cancer: Liverpool experience.. Journal of Clinical Oncology, 34(2_suppl), 396-396.
- IMvigor 210, a phase II trial of atezolizumab (MPDL3280A) in platinum-treated locally advanced or metastatic urothelial carcinoma (mUC).. Journal of Clinical Oncology, 34(2_suppl), 355-355.
- Venous thromboembolism (VTE) risk in patients with localized urinary tract tumors (UTT).. Journal of Clinical Oncology, 34(2_suppl), 422-422.
- The cell cycle regulator p27Kip1 is associated with urothelial bladder cancer invasion. International Journal of Clinical and Experimental Pathology, 9(10), 10515-10521.
- DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer. New England Journal of Medicine, 373(18), 1697-1708.
- 2619 Patterns and potential benefit of adjuvant chemotherapy for residual muscle invasive disease after neoadjuvant chemotherapy for muscle invasive urothelial cancer (MIUC). European Journal of Cancer, 51, S518-S518.
- 2632 VICTOR: Vinflunine in advanced metastatic transitional cell carcinoma of the urothelium (TCCU): A retrospective analysis of the use of Vinflunine in a multi-centre real life setting as second line chemotherapy through the free of charge programme (FOCP) for patients in the UK. European Journal of Cancer, 51, s523.
- 2642 The predictive and prognostic value of tumour necrosis in muscle invasive bladder cancer patients receiving radiotherapy with or without chemotherapy in the BC2001 (CRUK/01/004) trial. European Journal of Cancer, 51, s527-s528.
- Comparative effectiveness of gemcitabine plus cisplatin versus methotrexate, vinblastine, doxorubicin, plus cisplatin as neoadjuvant therapy for muscle-invasive bladder cancer. Cancer, 121(15), 2586-2593.
- The international normalized ratio does not reflect bleeding risk in esophageal variceal hemorrhage. Saudi Journal of Gastroenterology, 21(4), 254-254.
- Bladder reconstruction: The past, present and future. Oncology Letters, 10(1), 3-10.
- Adjuvant chemotherapy for residual disease after neoadjuvant chemotherapy for muscle invasive urothelial cancer (MIUC).. Journal of Clinical Oncology, 33(15_suppl), 4524-4524.
- A phase II/III, double-blind, randomized trial comparing maintenance lapatinib versus placebo after first line chemotherapy in HER1/2 positive metastatic bladder cancer patients.. Journal of Clinical Oncology, 33(15_suppl), 4505-4505.
- Cisplatin-Based First-Line Therapy for Advanced Urothelial Carcinoma After Previous Perioperative Cisplatin-Based Therapy. Clinical Genitourinary Cancer, 13(2), 178-184.
- VICTOR: Vinflunine (Vin) in advanced metastatic transitional cell carcinoma of the urothelium (TCCU)—A retrospective analysis of use of Vin in multicenter, real life setting as second-line chemotherapy (ChT) through free-of charge-programme (FOCP) for patients (pts) in the UK.. Journal of Clinical Oncology, 33(7_suppl), 352-352.
- Phase II randomised placebo controlled neoadjuvant chemotherapy study of nintedanib with gemcitabine and cisplatin in locally advanced muscle invasive bladder cancer. Journal of Clinical Oncology, 33 (supplement; abstract TPS4574).
- A phase I, open-label, multicenter study to evaluate the pharmacokinetics and safety of oral panobinostat in patients with advanced solid tumors and varying degrees of renal function. Cancer Chemotherapy and Pharmacology, 75(1), 87-95.
- 572 Oral panobinostat in patients with advanced tumors and impaired renal function: Relationship between pharmacokinetics and key safety parameters. European Journal of Cancer, 50, 185.
- Outcomes with Cisplatin-Based First-Line Therapy for Advanced Urothelial Carcinoma (Uc) Following Previous Perioperative Cisplatin-Based Therapy. Annals of Oncology, 25, iv302.
- A Phase 1/2 Study of At13387, a Heat Shock Protein 90 (Hsp90) Inhibitor in Combination with Abiraterone Acetate (Aa) and Prednisone (P) in Patients (Pts) with Castration-Resistant Prostate Cancer (Mcrpc) No Longer Responding to Aa. Annals of Oncology, 25, iv267.
- The Nrf2 transcription factor contributes to resistance to cisplatin in bladder cancer. Urologic Oncology: Seminars and Original Investigations, 32(6), 806-814.
- Pazopanib versus paclitaxel in relapsed urothelial tumors: A randomized phase II study investigating pazopanib versus weekly paclitaxel in relapsed or progressive transitional cell carcinoma of the urothelium (PLUTO).. Journal of Clinical Oncology, 32(15_suppl), tps4589-tps4589.
- Comparative effectiveness of gemcitabine plus cisplatin (GC) versus methotrexate, vinblastine, doxorubicin, plus cisplatin (MVAC) as neoadjuvant therapy for muscle-invasive bladder cancer (MIBC).. Journal of Clinical Oncology, 32(15_suppl), 4512-4512.
- Low vitamin D level is an independent predictor of poor outcomes in Clostridium difficile-associated diarrhea. Therapeutic Advances in Gastroenterology, 7(1), 14-19.
- The Detection of Hepatocellular Carcinoma Using a Prospectively Developed and Validated Model Based on Serological Biomarkers. Cancer Epidemiology Biomarkers & Prevention, 23(1), 144-153.
- Randomized Noninferiority Trial of Reduced High-Dose Volume Versus Standard Volume Radiation Therapy for Muscle-Invasive Bladder Cancer: Results of the BC2001 Trial (CRUK/01/004). International Journal of Radiation Oncology*Biology*Physics, 87(2), 261-269.
- Fecal Immunochemical Testing for Colorectal Cancer Screening in Average Risk Individuals: Fit for Detecting Neoplasia?. The American Journal of Gastroenterology, 108, s628.
- Pooled Analysis of Phase II Trials Evaluating Weekly or Conventional Cisplatin as First-Line Therapy for Advanced Urothelial Carcinoma. Clinical Genitourinary Cancer, 11(3), 316-320.
- Sorafenib for advanced hepatocellular carcinoma (HCC): impact of rationing in the United Kingdom. British Journal of Cancer, 109(4), 888-890.
- Clinical outcomes in patients with castrate-refractory prostate cancer (CRPC) metastatic to bone randomized in the factorial TRAPEZE trial to docetaxel (D) with strontium-89 (Sr89), zoledronic acid (ZA), neither, or both (ISRCTN 12808747).. Journal of Clinical Oncology, 31(18_suppl), LBA5000-LBA5000.
- Clinical outcomes in patients with castrate-refractory prostate cancer (CRPC) metastatic to bone randomized in the factorial trapeze trial to docetaxel (D) with strontium-89 (Sr89), zoledronic acid (ZA), neither, or both (ISRCTN 12808747).. Journal of Clinical Oncology, 31(15_suppl), lba5000-lba5000.
- Gene expression profiling in bladder cancer to identify potential therapeutic targets.. Journal of Clinical Oncology, 31(15_suppl), 4518-4518.
- Pillcam ESO® is more accurate than clinical scoring systems in risk stratifying emergency room patients with acute upper gastrointestinal bleeding. Therapeutic Advances in Gastroenterology, 6(3), 193-198.
- A Multidisciplinary Approach in Muscle-Invasive Disease: Novel Chemotherapy Combinations and Targets in Chemoradiation. American Society of Clinical Oncology Educational Book, 33, 200-206.
- Changing angles: Successful treatment of superior mesenteric artery syndrome with double-balloon enteroscopy-assisted direct feeding jejunostomy. Digestive Endoscopy, 24(6), 482-482.
- UNIQUE USAGE OF A PARTIALLY COVERED METAL STENT FOR DRAINAGE OF A PANCREATIC PSEUDOCYST VIA ENDOSONOGRAPHY-GUIDED TRANSCYSTGASTROSTOMY. Digestive Endoscopy, 24(3), 185-187.
- Radiotherapy with or without Chemotherapy in Muscle-Invasive Bladder Cancer. New England Journal of Medicine, 366(16), 1477-1488.
- Tu1666 Comparison of the Third Eye Retroscope® to Standard Retroflexion in Evaluating the Rectum. Gastrointestinal Endoscopy, 75(4), ab481-ab482.
- Prevalence of Adenomas Found on Colonoscopy in Patients With HIV.. Gastroenterology Res, 5(2), 52-56.
- Ketamine-induced Biliary Dilatation. Journal of Addiction Medicine, 6(1), 89-91.
- Active surveillance for prostate cancer: Scottish experience.. Journal of Clinical Oncology, 30(5_suppl), 167-167.
- Pooled analysis of phase II trials evaluating weekly or conventional cisplatin as first-line therapy for advanced urothelial carcinoma (UC).. Journal of Clinical Oncology, 30(5_suppl), 308-308.
- Gemcitabine chemotherapy until symptomatic disease progression in advanced pancreatic cancer: A retrospective analysis.. Journal of Clinical Oncology, 30(4_suppl), 372-372.
- The Successful Treatment of Chronic Cholecystitis with SpyGlass Cholangioscopy-Assisted Gallbladder Drainage and Irrigation through Self- Expandable Metal Stents. Gut and Liver, 6(1), 136-138.
- Assessment of high-throughput high-resolution MALDI-TOF-MS of urinary peptides for the detection of muscle-invasive bladder cancer. PROTEOMICS - Clinical Applications, 5(9-10), 493-503.
- Full Liquid Diet vs Clear Liquid Diet for Colonoscopy Preparation: Preliminary Results. The American Journal of Gastroenterology, 106, s559.
- A 14 cm Long Gastro-colic Fistula Repair via a Novel Endoscopic Technique: A Simultaneous Dual Scope Approach Utilizing Endoclips. The American Journal of Gastroenterology, 106, s377.
- Diagnosis of multifocal small bowel carcinoid with double balloon Enteroscopy. Practical Gastroenterology, 35(9), 60-63.
- Tu1621 Double Balloon Enteroscopy Assisted Percutaneous Jejunostomy Placement. Gastrointestinal Endoscopy, 73(4), ab465.
- Effectiveness of trans-arterial embolisation of liver neuroendocrine tumour metastases. Gut, 60(Suppl 1), a115.
- Live View Video Capsule Endoscopy Enables Risk Stratification of Patients with Acute Upper GI Bleeding in the Emergency Room: A Pilot Study. Digestive Diseases and Sciences, 56(3), 786-791.
- Role of Second-Line Systemic Treatment Post-Docetaxel in Metastatic Castrate Resistant Prostate Cancer- Current Strategies and Future Directions. Anti-Cancer Agents in Medicinal Chemistry, 11(3), 296-306.
- Tumour biology of germ cell tumours. Hematology/Oncology Clinics of North America, 25, 457-471.
- Biology of Germ Cell Tumors. Hematology/Oncology Clinics of North America, 25(3), 457-471.
- Chemotherapy for breast cancer (review). Oncology Reports, 24(5), 1121-1131.
- Results of a 2 x 2 Phase III Randomized Trial of Synchronous Chemo-radiotherapy (CRT) Compared to Radiotherapy (RT) Alone and Standard vs. Reduced High Volume RT in Muscle Invasive Bladder Cancer (MIBC) (BC2001 CRUK/01/004). International Journal of Radiation Oncology • Biology • Physics, 78(3), s2-s3.
- Endoscopic Ultrasound Guided Drainage of Large Pancreatic Pseudocyst by Partially-Covered Metal Stent. The American Journal of Gastroenterology, 105, s198.
- Identification of a molecular profile that may predict early relapse in patients undergoing multimodality therapy in muscle-invasive bladder cancer (MIBC).. Journal of Clinical Oncology, 28(15_suppl), e15118-e15118.
- Results of a phase III randomized trial of synchronous chemoradiotherapy (CRT) compared to radiotherapy (RT) alone in muscle-invasive bladder cancer (MIBC) (BC2001 CRUK/01/004).. Journal of Clinical Oncology, 28(15_suppl), 4517-4517.
- S1423: PillCam ESO® Is More Accurate Than Clinical Scoring Systems in Risk Stratifying Emergency Room Patients With Acute Upper Gastrointestinal Bleeding. Gastrointestinal Endoscopy, 71(5), ab157-ab158.
- The West Midlands Bladder Cancer Prognosis Programme: rationale and design. BJU International, 105(6), 784-788.
- Recent Advances and Future Directions in the Management of Metastatic Renal Cell Carcinoma. Anti-Cancer Agents in Medicinal Chemistry, 10(3), 225-235.
- Erratum. Hemodialysis International, 14(1), 152-152.
- Advances in chemotherapy in breast cancer.. Oncology Report, 24, 1121-1131.
- Identification of Small Bowel Diverticula with Double-Balloon Enteroscopy Following Non-diagnostic Capsule Endoscopy. Digestive Diseases and Sciences, 54(10), 2296-2297.
- Rapid Evaluation of the Upper GI Tract Using Real-Time Pillcam™ ESO in Emergency Room Patients with Acute UGI Bleeding. The American Journal of Gastroenterology, 104, s502.
- Risk Stratification of Upper GI Bleeding Patients in the Emergency Room with “Real Time” Capsule Endoscopy - A Pilot Study. The American Journal of Gastroenterology, 104, s401.
- 7102 Updated results of the BC2001 phase III randomized trial of standard vs reduced high dose volume radiotherapy for muscle invasive bladder cancer (ISCRTN:68324339): tumour control, toxicity and quality of life. European Journal of Cancer Supplements, 7(2), 423-423.
- Outcomes of critically ill patients with acute kidney injury and end-stage renal disease requiring renal replacement therapy: a case-control study. Nephrology Dialysis Transplantation, 24(7), 2290-2290.
- Role of Tyrosine Kinase Inhibitors in Lung Cancer. Anti-Cancer Agents in Medicinal Chemistry, 9(5), 569-575.
- Adjuvant hysterectomy following unsuccessful intracavitary brachytherapy in cervical carcinoma. Journal of Clinical Oncology, 27(15_suppl), e16543-e16543.
- Carboplatin, ifosfamide, and mesna (CIM) for the treatment of gynecological carcinosarcoma. Journal of Clinical Oncology, 27(15_suppl), e16539-e16539.
- Outcome among patients with acute renal failure needing continuous renal replacement therapy: A single center study. Hemodialysis International, 13(2), 205-214.
- Re-challenging with Docetaxel chemotherapy following relapse: Is this an effective treatment strategy. Prostate Cancer Forum, 5, 1-9.
- Chemotherapy related encephalopathy in a patient with Stage IV cervical carcinoma treated with cisplatin and 5-fluorouracil: a case report. Cases Journal, 2(1), 8526-8526.
- Biology of testicular germ cell tumors. Expert Review of Anticancer Therapy, 8(10), 1659-1673.
- First Toxicity Report of the BC2001 Trial: A Multicentre Phase III Randomised Trial of Radiotherapy with and without Synchronous Chemotherapy in Muscle Invasive Bladder Cancer ISCRTN No. 68324339, EUDRACT No. 2004-000164-26. International Journal of Radiation Oncology • Biology • Physics, 72(1), s7.
- Pegylated liposomal doxorubicin for epithelial ovarian cancer: The utility of Ca125 trends in guiding treatment decisions and subsequent response to platinum retreatment. Journal of Clinical Oncology, 26(15_suppl), 16539-16539.
- Docetaxel re-treatment for metastatic hormone refractory prostate cancer. Journal of Clinical Oncology, 26(15_suppl), 16066-16066.
- Multifocal Granular Cell Tumor Presenting as an Esophageal Stricture. Journal of Gastrointestinal Cancer, 39(1-4), 107-113.
- Genomics and Pharmacogenomics in the Management of Breast Cancer. Current Pharmacogenomics and Personalized Medicine, 6(1), 45-55.
- Management of metastatic germ cell tumors. Expert Review of Anticancer Therapy, 8(5), 771-784.
- Access to Kidney Transplantation among Patients Insured by the United States Department of Veterans Affairs. Journal of the American Society of Nephrology, 18(9), 2592-2599.
- The role of neoadjuvant chemotherapy in muscle invasive bladder cancer and correlation of clinical outcome with translational studies. Journal of Clinical Oncology, 25(18_suppl), 15551-15551.
- Reply: Randomised studies with translational end points are required to further elucidate the prognostic and predictive value of CA IX. British Journal of Cancer, 96(8), 1310-1310.
- Hypoxia-regulated carbonic anhydrase IX expression is associated with poor survival in patients with invasive breast cancer. British Journal of Cancer, 96(1), 104-109.
- Molecularly Targeted Therapeutics for Breast Cancer. BioDrugs, 21(4), 215-224.
- Signal Transduction Therapy: Challenges to Clinical Trial Design. Current Signal Transduction Therapy, 2(1), 21-30.
- Rifaximin, Omeprazole and Levofloxacin for the Treatment of Helicobacter pylori in the Treatment-Naive Population. The American Journal of Gastroenterology, 101, s90-s91.
- BK virus infection after renal transplantation. Current Opinion in Organ Transplantation, 11(4), 413-417.
- REDUCTION IN IMMUNOSUPPRESSION WITHOUT USE OF ANTI-VIRAL THERAPY IN THE TREATMENT OF BK VIRUS INFECTION AFTER RENAL TRANSPLANT.. Transplantation, 82(1), 938-939.
- A feasibility/phase II study of gemcitabine (G) and split dose cisplatin (C) in advanced or metastatic non-small cell lung cancer (NSCLC) in an outpatient setting. Journal of Clinical Oncology, 24(18_suppl), 17048-17048.
- BK virus nephritis: Risk factors, timing, and outcome in renal transplant recipients. Kidney International, 68(4), 1834-1839.
- A pilot/phase II study of gemcitabine (G) and split dose cisplatin (C) in advanced or metastatic non-small cell lung cancer (NSCLC) in an outpatient setting. Journal of Clinical Oncology, 23(16_suppl), 7272-7272.
- Phosphorus-enriched hemodialysis during pregnancy: Two case reports. Hemodialysis International, 9(2), 147-152.
- Management of muscle invasive bladder cancer?British approaches to organ conservation. Seminars in Radiation Oncology, 15(1), 19-27.
- Gene- and immunotherapy for hepatocellular carcinoma. Expert Opinion on Biological Therapy, 5(4), 507-523.
- Role of chemotherapy in breast cancer. Expert Review of Anticancer Therapy, 5(6), 1095-1110.
- Molecular markers in bladder cancer. Seminars in Radiation Oncology, 15(1), 3-9.
- Molecular pathways in bladder cancer: Part 1. BJU International, 95(4), 485-490.
- Molecular pathways in bladder cancer: Part 2. BJU International, 95(4), 491-496.
- Management of muscle invasive bladder cancer – can we improve the results of bladder preserving therapy?. Seminars in Radiation Oncology, 15(1), 19-27.
- Systemic therapies for hepatocellular carcinoma. Expert Opinion on Investigational Drugs, 13(12), 1555-1568.
- A phase I/II study of gemcitabine and fractionated cisplatin in an outpatient setting using a 21-day schedule in patients with advanced and metastatic bladder cancer. British Journal of Cancer, 91(5), 844-849.
- Long-term results of a phase II study of synchronous chemo radiotherapy in muscle invasive bladder cancer. Journal of Clinical Oncology, 22(14_suppl), 4585-4585.
- Long-term results of a phase II study of synchronous chemo radiotherapy in muscle invasive bladder cancer. Journal of Clinical Oncology, 22(14_suppl), 4585-4585.
- Long-term results of a phase II study of synchronous chemoradiotherapy in advanced muscle invasive bladder cancer. British Journal of Cancer, 90(11), 2106-2111.
- Endocrine therapy for early breast cancer. Expert Review of Anticancer Therapy, 4(5), 877-888.
- Endocrine therapy and other targeted therapies for metastatic breast cancer. Expert Review of Anticancer Therapy, 4(6), 1179-1195.
- CD40 expression in prostatic carcinomas. Oncology Reports: an international journal devoted to fundamental and applied research in oncology, 12(4), 679-682.
- Role of hypoxic marker CA IX in Transitional cell carcinoma of the bladder.. Oncology Reports: an international journal devoted to fundamental and applied research in oncology, 11(5), 1005-1010.
- Role of endocrine therapy in early breast cancer. Expert Review of Anticancer Therapy, 5, 877-888.
- Role of endocrine therapy in metastatic breast cancer.. Expert Review of Anticancer Therapy, 6, 1179-1195.
- The systemic treatment of advanced and metastatic bladder cancer. The Lancet Oncology, 4(8), 489-497.
- Expression of pituitary tumour transforming gene (PTTG) and fibroblast growth factor-2 (FGF-2) in human pituitary adenomas: relationships to clinical tumour behaviour. Clinical Endocrinology, 58(2), 141-150.
- Proapoptotic genes BAX and CD40L are predictors of survival in transitional cell carcinoma of the bladder. British Journal of Cancer, 88(4), 586-592.
- Successful treatment of radiation nephropathy with angiotensin II blockade. International Journal of Radiation Oncology*Biology*Physics, 55(1), 190-193.
- BCL2 expression predicts survival in patients receiving synchronous chemoradiotherapy in advanced transitional cell carcinoma of the bladder. Oncology Reports, 10(3), 571-576.
- Organ preservation strategies in bladder cancer. Expert Review of Anticancer Therapy, 2(6), 641-651.
- Vascular Endothelial Growth Factor, Its Receptor KDR/Flk-1, and Pituitary Tumor Transforming Gene in Pituitary Tumors. The Journal of Clinical Endocrinology & Metabolism, 87(9), 4238-4244.
- Rapid kidney allograft failure in patients with polyoma virus nephritis with prior treatment with antilymphocyte agents. Clinical Transplantation, 16(1), 43-47.
- A phase I–II study of synchronous chemoradiotherapy for poor prognosis locally advanced bladder cancer. Annals of Oncology, 12(7), 929-935.
- Pre-clinical and clinical study of QC12, a water-soluble, pro-drug of quercetin. Annals of Oncology, 12(2), 245-248.
- Virus-directed, enzyme prodrug therapy with nitroimidazole reductase: A phase I and pharmacokinetic study of its prodrug, CB1954. Clinical Cancer Research, 7(9), 2662-2668.
- Hepatocellular carcinoma. Annals of Oncology, 12(2), 161-172.
- Role of chemotherapy in anal tumours. GI Cancer, 3(3), 181-187.
- Docetaxel chemotherapy for metastatic hormone refractory prostate cancer as first-line palliative chemotherapy and subsequent re-treatment: Birmingham experience. Oncology Reports, 20(4).
- First-line avelumab plus chemotherapy in patients with advanced solid tumors: results from the phase 1b/2 JAVELIN Chemotherapy Medley study. Cancer Research Communications.
- Systemic anticancer therapy for urothelial carcinoma: UK oncologists’ perspective. British Journal of Cancer.
- A Phase Ib/II study of IGF-neutralising antibody xentuzumab with enzalutamide in metastatic castration-resistant prostate cancer. British Journal of Cancer.
- Analysis of the distal urinary tract in larval and adult zebrafish reveals homology to the human system. Disease Models & Mechanisms.
- First-line Systemic Treatment Options for Metastatic Castration-Sensitive Prostate Cancer. JAMA Oncology.
- Disparities in the Inclusion of Racial and Ethnic Minority Groups and Older Adults in Prostate Cancer Clinical Trials. JAMA Oncology.
- TUXEDO: A phase I/II trial of cetuximab with chemoradiotherapy in muscle‐invasive bladder cancer. BJU International.
- Social deprivation and bladder cancer: cause or effect for disparities in survival for affected women. BJU International.
- Urine dna for monitoring chemoradiotherapy response in muscle‐invasive bladder cancer: A pilot study. BJU International.
- Bladder cancer: shedding light on the most promising investigational drugs in clinical trials. Expert Opinion on Investigational Drugs.
- Phase I Trial of DNA Methyltransferase Inhibitor Guadecitabine Combined with Cisplatin and Gemcitabine for Solid Malignancies Including Urothelial Carcinoma (SPIRE). Clinical Cancer Research.
- Therapeutics discovery: From bench to first in-human trials*. Biomedical Reports.
- Repair of a gastrocolic fistula using a wire-guided, simultaneous dual scope approach. Endoscopy, 45(S 02), E307-E308.
- CD40 expression in prostate cancer: A potential diagnostic and therapeutic molecule. Oncology Reports.
- Carbonic anhydrase IX, a marker of hypoxia: Correlation with clinical outcome in transitional cell carcinoma of the bladder. Oncology Reports.
- Molecular Mechanisms Involved in the Transition of Prostate Cancer Cells from Androgen Dependant to Castration Resistant State. Journal of Andrology and Gynaecology, 2(3).
- Critical appraisal of axitinib in the treatment of advanced renal cell carcinoma. Biologics: Targets and Therapy, 39-39. View this article in WRRO
- Management of renal angiomyolipoma in patients with tuberous sclerosis complex. Oncology Reports.
- A study of split-dose cisplatin-based neo-adjuvant chemotherapy in muscle-invasive bladder cancer. Oncology Letters.
- A phase II clinical trial of gemcitabine and split dose cisplatin in advanced non-small cell lung cancer in an outpatient setting. Oncology Reports.
- The use of self-expandable metal stents in the palliation of malignant bowel obstruction. Oncology Reports.
- Hypofractionated radiotherapy in invasive bladder cancer: an individual patient data meta‐analysis of the BC2001 and BCON trials. Lancet Oncology.
Chapters
- A multidisciplinary approach in muscle-invasive disease In Hussain S (Ed.), American Society Clinical Oncology Education Book
- Systematic chemotherapy for liver tumours In Fong , Poon , Tang , Dupuy & Berlin (Ed.), Hepatobiliary Cancer
- Bladder cancer, in Perez and Brady's Principles and Practice of Radiation Oncology In Halperin EC, Wazer DE, Perez CA & Brady LW (Ed.), Percy and Brady textbook of radiation oncology
- Concomitant chemo-radiotherapy principles and management In Price (Ed.), Treatment of Cancer
Conference proceedings papers
- Stratified absolute benefit with adjuvant immunotherapy (aIO) in muscle-invasive bladder cancer (MIBC): A meta-analysis. JOURNAL OF CLINICAL ONCOLOGY, Vol. 42(16)
- Cost-effectiveness analysis of contemporary first-line (1L) agents in locally advanced/metastatic urothelial carcinoma (la/mUC). JOURNAL OF CLINICAL ONCOLOGY, Vol. 42(16)
- Use of gene expression patterns to identify unique molecular subtypes in muscle invasive bladder cancer: GUSTO. JOURNAL OF CLINICAL ONCOLOGY, Vol. 42(16)
- SOGUG-NEOWIN: A Phase 2, open-label, multi-centre, multi-national interventional trial evaluating the efficacy and safety of Erdafitinib (ERDA) monotherapy and ERDA and Cetrelimab (CET) as neoadjuvant treatment in cisplatin-ineligible patients with Muscle-Invasive Bladder Cancer (MIBC) whose tumours express FGFR gene alterations. EUROPEAN UROLOGY, Vol. 85 (pp S427-S427)
- The role of volume of disease for treatment selection in patients with metastatic castration sensitive prostate cancer (mCSPC): A living meta-analysis. JOURNAL OF CLINICAL ONCOLOGY, Vol. 41(16)
- MEASURING OBJECTIVE RECOVERY OF ACTIVITY LEVELS USING WEARABLE DEVICES FOLLOWING OPEN VS INTRACORPOREAL ROBOTIC CYSTECTOMY: SECONDARY OUTCOMES ANALYSIS OF THE IROC RANDOMIZED TRIAL. JOURNAL OF UROLOGY, Vol. 209 (pp E985-E985)
- Quantifying the absolute benefit of neoadjuvant chemotherapy followed by definitive therapy in patients with muscle-invasive bladder cancer: A systematic review and meta-analysis.. JOURNAL OF CLINICAL ONCOLOGY, Vol. 40(16)
- Mixed treatment comparisons evaluating contemporary therapies in metastatic castration sensitive prostate cancer (mCSPC): A living systematic review. ANNALS OF ONCOLOGY, Vol. 33(7) (pp S1193-S1193)
- A randomised, double blind, phase II clinical trial of maintenance cabozantinib following chemotherapy for metastatic urothelial carcinoma (mUC): Final analysis of the ATLANTIS cabozantinib comparison.. JOURNAL OF CLINICAL ONCOLOGY, Vol. 40(17)
- RESULTS OF THE INTRACORPOREAL ROBOTIC VS OPEN CYSTECTOMY (IROC) MULTI-CENTRE RANDOMISED TRIAL. JOURNAL OF UROLOGY, Vol. 207(5) (pp E695-E695)
- Phase II randomized placebo-controlled neoadjuvant trial of nintedanib or placebo with gemcitabine and cisplatin in locally advanced muscle invasive bladder cancer (NEO-BLADE). JOURNAL OF CLINICAL ONCOLOGY, Vol. 38(6)
- Outcomes of advanced plasmacytoid urothelial carcinoma receiving systemic therapy. JOURNAL OF CLINICAL ONCOLOGY, Vol. 38(6)
- A phase I/II feasibility study of cetuximab with 5FU and mitomycin C or cisplatin with concurrent radiotherapy in muscle invasive bladder cancer. JOURNAL OF CLINICAL ONCOLOGY, Vol. 38(6)
- Changing Landscape in the Management of Advanced Bladder Cancer. JOURNAL OF PATHOLOGY, Vol. 249 (pp S10-S10)
- Hypo-Fractionation in Muscle-Invasive Bladder Cancer: An Individual Patient Data (IPD) Meta-Analysis of the BC2001 and BCON Trials. International Journal of Radiation Oncology*Biology*Physics, Vol. 105(1) (pp S138-S138)
- Biomarker analyses of ramucirumab in patients with platinum refractory urothelial cancer from RANGE, a global, randomized, double-blind, phase III study. ANNALS OF ONCOLOGY, Vol. 30
- Difference in Acute Ischemic Post Thrombolytic Stroke Outcomes in Pre Comprehensive and Post Comprehensive Status: Single Center Experience. STROKE, Vol. 47
- A randomized phase II study of AZ2014 versus everolimus in patients with VEGF refractory metastatic clear cell renal cancer (mRCC).. Journal of Clinical Oncology, Vol. 33(7_suppl) (pp 409-409)
- Clinical outcomes in patients with castrate-refractory prostate cancer (CRPC) metastatic to bone randomized in the factorial TRAPEZE trial to docetaxel (D) with strontium-89 (Sr89), zoledronic acid (ZA), neither, or both (ISRCTN 12808747).. JOURNAL OF CLINICAL ONCOLOGY, Vol. 31(18)
- Clinical outcomes in patients with castrate-refractory prostate cancer (CRPC) metastatic to bone randomized in the factorial trapeze trial to docetaxel (D) with strontium-89 (Sr89), zoledronic acid (ZA), neither, or both (ISRCTN 12808747).. JOURNAL OF CLINICAL ONCOLOGY, Vol. 31(15)
Posters
- PD42-02 RESULTS OF THE INTRACORPOREAL ROBOTIC VS OPEN CYSTECTOMY (IROC) MULTI-CENTRE RANDOMISED TRIAL.
Preprints
- Analysis of the Distal Urinary Tract in Larval and Adult Zebrafish Reveals Unrecognized Homology to the Human System, Cold Spring Harbor Laboratory.
- ATLANTIS: An adaptive multi-arm phase II trial of maintenance targeted therapy after chemotherapy in patients with metastatic urothelial cancer, Research Square Platform LLC.
- ATLANTIS: An adaptive multi-arm phase II trial of maintenance targeted therapy after chemotherapy in patients with metastatic urothelial cancer, Research Square Platform LLC.
- Teaching interests
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I regularly taught pharmacology to both undergraduate and postgraduate students in my previous roles and supervised both MSc and PhD students in both their projects and research. I am also:
- Deputy Lead of Urology & Renal Phase 2a MBChB
- Academic Lead for Medical Oncology Clinical Academic Training Programme.
- Professional activities and memberships
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- Association of Cancer Physicians (ACP)
- European Society of Medical Oncology (ESMO)
- American Society of Clinical Oncology (ASCO)
- NCRI Blader & Renal Clinical studies group
- British Medical Association
- Chair of the NCRI Advanced Bladder Cancer – subgroup