Dr Christopher McDermott (MBChB FRCP PhD)
Senior Lecturer and Honorary Consultant Neurologist
University of Sheffield
Faculty of Medicine, Dentistry and Health
Department of Neuroscience
Sheffield Institute of Translational Neuroscience
385a Glossop Road
United Kingdom, S10 2HQ
Telephone: 0114 22 22236
Fax: 0114 22 22290
Secretary: Rebecca Brown
Telephone: 0114 22 22261
I am interested in studying mechanisms of neurodegeneration in order to develop treatments for patients with motor neuron disease and hereditary spastic paraplegia. My current active projects include:
- Epidemiology of motor neuron disease
- Models of neurodegeneration in motor system disorders
- Genetic and phenotypic characterisation of motor system disorders
- Natural history study of motor system disorders
- Drug trials in MND
- Management of respiratory insufficiency in MND/ALS
Clinical Senior Lecturer in Neurology.
Specialist Training in Neurology (CCT), Sheffield
Wellcome Trust Research Training Fellowship (PhD), University of Sheffield.
Clinical Research Fellow, University of Newcastle upon Tyne.
Specialist Training in Neurology, Leeds.
General professional training (MRCP), Leeds Teaching Hospitals.
Medicine (MBChB), University of Leeds.
Member of DeNDRoN MND CSG
Member of NICE NIV Guideline Development Group
Member of Royal College of Physicians Neurology Speciality Advisory Committee
South Yorkshire Neurology Training Programme Director/ Chair Specialty Training Committee
Association of British Neurologists, Bournemouth 2010
Familial Spastic Paraplegia Support Group UK 2008
European Neurological Society, Rhodes 2007
Principal Funding Source:
- Motor Neurone Disease Association, UK
- Medical Research Council (MRC)
- National Institute of Health Research (NIHR)
Members of Research Group:
- Dr Ceryl Moore
- Marc DaCosta
- Rohinni Raman
- Sue Thompson
- Theocharis Stavroulakis
- Dr Muhammad Rafiq
Christopher Hewitt, MBChB; Janine Kirby, PhD; J. Robin Highley, DPhil; Judith A. Hartley; Rachael Hibberd, DipHE; Hannah C. Hollinger, MA; Tim L. Williams, PhD;Paul G. Ince, MD; Christopher J. McDermott, PhD; Pamela J. Shaw, MD. Novel FUS/TLS Mutations and Pathology in Familial and Sporadic Amyotrophic Lateral Sclerosis. Arch Neurol. 2010;67:455-461.
C Douglass, R Kandler, PJ Shaw and CJ McDermott. An evaluation of neurophysiological criteria used in the diagnosis of Motor Neurone Disease. J Neurol Neurosurg Neuropsych 2010; In Press
J Kirby, E Goodall W Smith, J R Highley, R Masanzu, JA Hartley, R Hibberd, HC Hollinger, SB Wharton, K Morrison, PG Ince, CJ McDermott and PJ Shaw. Broad clinical phenotypes associated with TAR-DNA binding protein (TARDBP) mutations in amyotrophic lateral sclerosis. Neurology 2009; In press.
Randomised controlled trial of methotrexate for chronic inflammatory
demyelinating polyradiculoneuropathy (RMC trial): a pilot, multicentre study. RMC Trial Group. Lancet Neurol. 2009;8:158-64.
C Hewamadduma, C McDermott, J Kirby, A Grierson, M Panayi, A Dalton, Y Rajabally, P Shaw. New pedigrees and novel mutation expand the phenotype of REEP1-associated hereditary spastic paraplegia (HSP). Neurogenetics. 2009;10:105-8
PR Kasher, KJ De Vos, SB Wharton, C Manser, EJ Bennett, M Bingley, JD Wood, R Milner, CJ McDermott, CC Miller, PJ Shaw, AJ Grierson. Direct evidence for axonal transport defects in a novel mouse model of mutant
spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients. J Neurochem 2009;110:34-44.
CA Harwood, CJ McDermott, PJ Shaw. Physical activity as an exogenous risk factor in motor neuron disease (MND): A review of the evidence. Amyotroph Lateral Sclerosis 2009;10:191-204
CA Hewamadduma, J Kirby, C Kershaw, J Martindale, A Dalton, CJ McDermott, PJ Shaw. HSP60 is a rare cause of hereditary spastic paraparesis, but may act as a genetic modifier. Neurology. 2008;70:1717-8.
CJ McDermott and PJ Shaw The clinical diagnosis and management of MND. BMJ 2008.
CJ McDermott, CE Burness, J Kirby, A Dalton, et al. Clinical features of hereditary spastic paraplegia due to spastin mutation. Neurology 2006 ;67:45-51
JD Wood, JA Landers, M Bingley, CJ McDermott, V Thomas-McArthur, LJ Gleadhall, PJ Shaw, VT Cunliffe. The microtubule severing protein spastin is essential for axon outgrowth in the zebrafish embryo. Human Molecular genetics 2006;15:2763-2771
CJ McDermott and PJ Shaw. Hereditary spastic paraplegia. Chapter 16. In : Handbook of Handbook of Clinical Neurology Series 3rd Edition. Motor Neuron Disorders. Elsevier. Editors Andrew Eisen, Pamela J Shaw. 2006
SB Wharton, CJ McDermott, A Grierson, C Gelsthorpe, PG Ince, PJ Shaw. The cellular and molecular pathology of the motor system in hereditary spastic paraparesis due to mutation of the spastin gene. J Neuropath Exp Neurol 2003; 62:166-77
CJ McDemott, AJ Grierson, JD Wood, M Bingley, SB Wharton, KMD Bushby, PJ Shaw. Hereditary spastic paraparesis: Disrupted intracellular transport associated with spastin mutation. Annals of Neurology 2003;54:796-803
CJ McDermott, DM Turnbull, KMD Bushby, PJ Shaw. Analysis of mitochondrial function in hereditary spastic paraparesis. NeuroReport 2003;14:485-48
CJ McDermott, RK Dayaratne, KMD Bushby, M Johnson, C Hayes, D Turnbull, PJ Shaw. Paraplegin gene analysis in hereditary spastic paraparesis (HSP) pedigrees in northeast England. Neurology 2001;56:467-471.
CJ McDermott, K White, K Bushby, PJ Shaw. Hereditary spastic paraparesis: A review of new developments. J Neurol Neurosurg Psychiatry 2000;6:150-160.